caffeine and camptothecin

caffeine has been researched along with camptothecin in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (27.27)18.2507
2000's11 (50.00)29.6817
2010's4 (18.18)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Andersson, HC; Kihlman, BA1
Shin, CG; Snapka, RM; Strayer, JM; Wani, MA1
Evans, A; Johnson, RT; Ryan, AJ; Squires, S; Strutt, HL1
Ardelt, B; Darzynkiewicz, RJ; Darzynkiewicz, Z; Gong, J; Kapuscinski, J; Traganos, F1
Kaneko, S; Mizuno, K; Okada, M1
Bernhard, EJ; Janss, AJ; Levow, C; McKenna, WG; Muschel, RJ; Phillips, PC; Sutton, L1
Wang, Y; Zhou, XY1
Enomoto, T; Kobayashi, T; Murofushi, H; Seki, M; Tada, S; Tsuyama, T1
Bhonde, MR; Boland, CR; Hanski, C; Hanski, ML; Magrini, R; Notter, M; ScherĂ¼bl, H; Zeitz, M1
Block, WD; Lees-Miller, SP; Meek, K; Merkle, D1
Arooz, T; Chow, JP; Ho, HT; Lau, A; Poon, RY; Siu, WY1
Ferrara, L; Kmiec, EB1
Chen, SY; Kussick, SJ; Roberson, RS; Vallieres, E; Wu, DY1
Feng, YD; Gong, JP; Tan, HL; Tao, DD; Xiao, H; Xie, DX; Yu, CN1
Blain, SW; Ye, W1
Kim, KP; Lee, BK; Yoon, S1

Other Studies

22 other study(ies) available for caffeine and camptothecin

ArticleYear
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Enhancement and reduction by methylated oxypurines of the frequencies of chromatid aberrations induced by camptothecin in root-tip cells of Vicia faba.
    Mutation research, 1992, Volume: 269, Issue:2

    Topics: Caffeine; Camptothecin; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Methylnitrosourea; Mutagenicity Tests; Mutagens; Plants; Purines; Theophylline; Uric Acid

1992
Rapid evaluation of topoisomerase inhibitors: caffeine inhibition of topoisomerases in vivo.
    Teratogenesis, carcinogenesis, and mutagenesis, 1990, Volume: 10, Issue:1

    Topics: Animals; Caffeine; Camptothecin; Etoposide; Haplorhini; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1990
Different fates of camptothecin-induced replication fork-associated double-strand DNA breaks in mammalian cells.
    Carcinogenesis, 1994, Volume: 15, Issue:5

    Topics: Animals; Caffeine; Camptothecin; Cell Line; CHO Cells; Chromosome Aberrations; Cricetinae; DNA; DNA Damage; DNA Replication; DNA, Neoplasm; Humans; Mitosis; Sensitivity and Specificity; Skin; Skin Physiological Phenomena; Urinary Bladder Neoplasms

1994
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells.
    Cancer research, 1993, Oct-01, Volume: 53, Issue:19

    Topics: Antineoplastic Agents; Apoptosis; Caffeine; Camptothecin; Cell Cycle; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Topotecan; Tumor Cells, Cultured

1993
Adenosine A1 and A2 receptors modulate extracellular dopamine levels in rat striatum.
    Neuroscience letters, 1996, Jul-05, Volume: 212, Issue:1

    Topics: Adenosine; Animals; Antihypertensive Agents; Caffeine; Camptothecin; Dopamine; Enzyme Inhibitors; Extracellular Space; Irinotecan; Male; Microdialysis; Neostriatum; Phenethylamines; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theobromine; Vasodilator Agents

1996
Caffeine and staurosporine enhance the cytotoxicity of cisplatin and camptothecin in human brain tumor cell lines.
    Experimental cell research, 1998, Aug-25, Volume: 243, Issue:1

    Topics: Apoptosis; Brain Neoplasms; Caffeine; Camptothecin; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; G2 Phase; Humans; Staurosporine; Tumor Cells, Cultured

1998
Inhibition of DNA replication in camptothecin-treated cells is regulated by protein kinases.
    Annals of the New York Academy of Sciences, 2000, Volume: 922

    Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Ataxia Telangiectasia Mutated Proteins; Caffeine; Camptothecin; Cell Cycle Proteins; DNA Damage; DNA Replication; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; HeLa Cells; Humans; Mutation; Nuclear Proteins; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Tumor Suppressor Proteins; Wortmannin

2000
Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract.
    Journal of cell science, 2002, Aug-01, Volume: 115, Issue:Pt 15

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Biotin; Caffeine; Camptothecin; Cell Cycle Proteins; Cell Extracts; Cell Nucleus; Cell-Free System; Deoxyuracil Nucleotides; DNA Damage; DNA Repair; DNA-Binding Proteins; Eukaryotic Cells; Female; Geminin; Genes, cdc; Male; Oocytes; Protein Serine-Threonine Kinases; Replication Protein A; Site-Specific DNA-Methyltransferase (Adenine-Specific); Spermatozoa; Tumor Suppressor Proteins; Xenopus laevis; Xenopus Proteins

2002
Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.
    International journal of cancer, 2002, Sep-01, Volume: 101, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Blotting, Western; Caffeine; Camptothecin; Carrier Proteins; CDC2 Protein Kinase; Cell Cycle; Colonic Neoplasms; Drug Resistance, Neoplasm; Flow Cytometry; Gene Deletion; Humans; Irinotecan; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2002
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine.
    Nucleic acids research, 2004, Volume: 32, Issue:6

    Topics: Animals; Caffeine; Camptothecin; Cell Extracts; Cell Line; Cricetinae; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Radiation-Sensitizing Agents; Replication Protein A

2004
Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:5

    Topics: Antibiotics, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Caffeine; Camptothecin; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; G1 Phase; G2 Phase; Genes, cdc; Guanine Nucleotide Exchange Factors; Humans; Nuclear Proteins; Protein Serine-Threonine Kinases; S Phase; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Suppressor Proteins

2004
Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination.
    Nucleic acids research, 2004, Volume: 32, Issue:17

    Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Base Sequence; Benzaldehydes; Caffeine; Camptothecin; Cell Line, Tumor; DNA Damage; DNA Repair; Green Fluorescent Proteins; Humans; Luminescent Proteins; Molecular Sequence Data; Oligonucleotides; Recombination, Genetic; Wortmannin

2004
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.
    Cancer research, 2005, Apr-01, Volume: 65, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Camptothecin; Carboplatin; Carcinoma, Non-Small-Cell Lung; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Cellular Senescence; G2 Phase; Humans; Lung Neoplasms; Neoadjuvant Therapy; Paclitaxel; Randomized Controlled Trials as Topic; Research Support as Topic; RNA, Small Interfering; Transcription, Genetic; Tumor Suppressor Protein p53

2005
[Effect of caffeine on camptothecin-induced apoptosis of Molt-4 cells].
    Ai zheng = Aizheng = Chinese journal of cancer, 2005, Volume: 24, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caffeine; Camptothecin; Cell Line, Tumor; Cell Proliferation; Humans; Leukemia, T-Cell; S Phase

2005
Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage.
    Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:5

    Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caffeine; Camptothecin; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebral Cortex; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Female; Genes, p53; Genomic Instability; Neurons; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Suppressor Proteins

2011
Caffeine enhances chemosensitivity to irinotecan in the treatment of colorectal cancer.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 121

    Topics: Adenocarcinoma; Caffeine; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; DNA; Humans; Irinotecan

2023