caffeine and allopurinol

caffeine has been researched along with allopurinol in 105 studies

Research

Studies (105)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (13.33)	18.7374
1990's	28 (26.67)	18.2507
2000's	39 (37.14)	29.6817
2010's	22 (20.95)	24.3611
2020's	2 (1.90)	2.80

Authors

Authors	Studies
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Abraham, MH; Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Berizzi, A; Bird, L; Culurgioni, S; Navratilova, IH; Olsen, RHJ; Rawlins, PB; Robinson, S; Shepherd, C; Thompson, LEJ; Varzandeh, S	1
Hossie, RD; McGilveray, IJ; Sved, S	1
Loft, S; Poulsen, HE; Vistisen, K	2
Bircher, J; Brandes, A; Compagnone, D; Hille, H; Münch, B; Ullrich, D	1
Ayers, GD; Evans, WE; Lin, JS; Relling, MV	1
Andersson, T; Bergstrand, R; Cederberg, C; Eriksson, S; Lagerström, PO; Skånberg, I	1
Kalow, W; Tang, BK	1
Barstow, L; Small, RE	1
Boda, D; Németh, I	1
Birkett, DJ; Kjellen, G; Lelo, A; Miners, JO	1
Gale, GR; Smith, AB	1
Kalow, W	2
Ben-Zvi, Z; Gorodischer, R; Margalith, M; Warszawski, D; Yaari, A	1
Campbell, ME; Grant, DM; Kalow, W; Tang, BK	1
Gohda, E; Iwata, H; Morita, E; Nishino, K; Yamamoto, I	1
Berlin, RD; Hawkins, RA	1
Bukowskyj, M; Munt, PW; Nakatsu, K	1
Grant, DM; Kalow, W; Tang, BK	1
Kela, U; Trivedi, CP; Vijayvargiya, R	1
Ben-Zvi, Z; Gorodischer, R; Warszawski, D	1
Beke, M; Hasler, JA; Kalow, W; Masimirembwa, CM; Tang, BK	1
Bennett, PN; Dobrocky, P; Farmer, KC; Notarianni, LJ; Nugent, KP; Oliver, S; Phillips, RK; Spigelman, AD	1
Alm, C; Benitez, J; Bertilsson, L; Bondesson, U; Carrillo, JA; Dahl, ML; Lindström, L; Llerena, A; Ramos, S; Rodriguez de la Rubia, I	1
Hamelin, BA; LeBel, M; Manseau, L; Richer, M; Vallé, F; Xu, K	1
Kirillova, TV; Spivak, IM	1
Fay, LB; Richoz, J; Stadler, RH; Turesky, RJ; Welti, DH	1
Brøsen, K; Rasmussen, BB	1
Benitez, J; Carrillo, JA	1
Goldhaber, JI	1
Birkett, DJ; Miners, JO	1
Benowitz, NL; Fenster, L; Hiatt, RA; Quale, C; Wilson, M; Windham, GC	1
Amsden, GW; Kashuba, AD; Kearns, GL; Nafziger, AN; Trépanier, EF	1
Bertino, JS; Gotschall, R; James, AW; Kashuba, AD; Kearns, GL; Leeder, JS; Nafziger, AN	1
Hageman, G; Krul, C	1
Bechtel, PR; Bechtel, YC; Bendriss, EK; Bennani, A; Brientini, MP; Mantion, G; Miguet, JP; Paintaud, G	1
Beck, DJ; Bertino, JS; Gotschall, R; Kashuba, AD; Kearns, GL; Kulawy, RW; Leeder, JS; Nafziger, AN; Rocci, ML	1
Fuchs, P; Haefeli, WE; Ledermann, HR; Wenk, M	1
Bliesath, H; Hartmann, M; Koch, H; Mascher, H; Steinijans, VW; Wurst, W; Zech, K	1
Madhavi, YS; Madyastha, KM; Sridhar, GR; Vadiraja, BB	1
Boda, D; Boda, M; Németh, I	1
Cha, YN; Cho, MH; Chung, WG; Kang, JH; Park, CS	1
Tamura, K; Wada-Takahashi, S	1
Bertino, JS; Bleakley, JF; Gaedigk, A; Gotschall, R; Kearns, GL; Kim, JS; Leeder, JS; Nafziger, AN; Streetman, DS	1
Castro, GD; Castro, JA; Costantini, MH; Delgado de Layño, AM	1
Bechtel, PR; Bechtel, YC; Brientini, MP; Hrusovsky, S; Lelouët, H; Mantion, G; Miguet, JP; Paintaud, G	1
Biollaz, J; Décosterd, LA; Kesselring, UW; Nyéki, A	1
Ishii, Y; Kodama, Y; Kotegawa, T; Kuranari, M; Matsuki, S; Miyakawa, I; Nakano, S; Tanaka, Y; Tsutsumi, K	1
Cao, XM; Ling, SS; Lu, JF; Yi, T; Zhuo, HT	1
Alzueta, AF; Orallo, F	1
Fujieda, M; Ishizaki, T; Kamataki, T; Nakagawa, K; Saruwatari, J; Shindo, J; Tajiri, T; Yamazaki, H	1
Aklillu, E; Bertilsson, L; Carrillo, JA; Ingelman-Sundberg, M; Makonnen, E	1
Bertino, JS; Chainuvati, S; Gaedigk, A; Kashuba, AD; Kearns, GL; Leeder, JS; Nafziger, AN; Rowland, E; Sellers, E; Zhang, Y	1
Benowitz, NL; Jacob, P; Peng, M	1
Echizen, H; Ishizaki, T; Nachi, S; Nakagawa, K; Saruwatari, J; Shindo, J	1
Krähenbühl, S; Todesco, L; Wenk, M	1
Abdel-Rahman, SM; Kashuba, AD; Kennedy, MJ; Leeder, JS	1
Bertino, JS; Gaedigk, A; Kashuba, AD; Kearns, G; Leeder, JS; Nafziger, AN; Rowland, E; Sellers, E; Shelepova, T; Victory, J; Zhang, Y	1
Fanlo, A; Ferrández-Longás, A; García de Jalón, A; Labarta, JI; Mayayo, E; Mayayo-Sinués, E; Sinués, B	1
Dash, SS; Gummadi, SN	1
Asprodini, EK; Begas, E; Kouvaras, E; Papakosta, S; Tsakalof, A	1
Fukushima, Y; Hisadome, M; Muramoto, Y; Nakagawa, K; Nakao, M; Saruwatari, J; Shoji, M; Yamano, N	1
Babu, VR; Karanth, NG; Kumar, MA; Patra, S; Thakur, MS	1
Burhenne, J; Göggelmann, C; Haefeli, WE; Mikus, G; Rengelshausen, J; Riedel, KD; Walter-Sack, I	1
Davis, DA; Gaedigk, A; Kearns, GL; Kennedy, MJ; Pearce, RE; Smith, N	1
Fuhr, U; Jetter, A; Kinzig, M; Rodamer, M; Sörgel, F; Tomalik-Scharte, D	1
Chen, Y; Fan, L; Guo, D; Han, Y; Huang, YF; Ou-Yang, DS; Tu, JH; Wang, YN; Xiao, P; Zhou, G; Zhou, HH	1
Abate, S; Bianco, G; Cataldi, TR; Labella, C	1
Hakooz, NM	1
Blake, M; Brown, KC; Gaedigk, A; Gotzkowsky, K; Hein, DW; Jones, AE; Kashuba, AD; van der Horst, C; Werner, RE	1
Aklillu, E; Carrillo, JA; Djordjevic, N; Gervasini, G; Jankovic, S	1
Barnes, WS; Kim, JH; Kwak, HB; Lawler, JM	1
Cao, S; Chen, BL; Chen, Y; He, YJ; Tan, ZR; Wang, G; Wang, LP; Xiao, CQ; Zhang, W; Zhou, G; Zhou, HH	1
Chiney, MS; Johnson, LA; Schwarzenberg, SJ	1
Aklillu, E; Bertilsson, L; Carrillo, JA; Djordjevic, N; Karlsson, S; Roh, HK; Ueda, N	1
Abe, T; Fujimura, Y; Kitamado, M; Muramoto, Y; Nakagawa, K; Saruwatari, J; Shimomasuda, M; Takaishi, C; Takashima, A; Umemoto, Y; Yoshida, K	1
Ding, TB; Imamura, M; Miyata, K; Nakagawa, K; Oniki, K; Saruwatari, J; Soraoka, H; Takashima, A; Tsuda, Y; Uchiyashiki, Y; Yoshida, K	1
Adehin, A; Bolaji, OO	1
Abooali, M; Berger, SM; Casely-Hayford, MA; Fasler-Kan, E; Gibbs, BF; Gonçalves Silva, I; Prokhorov, A; Sumbayev, VV; Yasinska, IM	1
Kadowaki, D; Kamihashi, R; Kita, A; Matsuda, K; Miyata, K; Nakagawa, K; Oniki, K; Ono, T; Saruwatari, J; Soraoka, H; Taharazako, K; Takashima, A; Uchiyashiki, Y; Yasui-Furukori, N	1
Asprodini, EK; Begas, E; Kilindris, T; Kouretas, D; Kouvaras, E; Tsioutsioumi, A	1
Choi, MS; Ji, YS; Kim, HJ; Nakamura, K; Rehman, SU; Yoo, HH; Yu, JS	1
Bernis, ME; Imam, FB; Maes, E; Maltepe, E; Pang, R; Pasca, AM; Robertson, NJ; Sabir, H; Schleehuber, Y; Silverman, J; White, Y; Zweyer, M	1

Reviews

6 review(s) available for caffeine and allopurinol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Ethnic differences in reactions to drugs and xenobiotics. Caffeine and other drugs. Progress in clinical and biological research, 1986, Volume: 214 Topics: Acetylation; Caffeine; Cytochrome P-450 Enzyme System; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Gene Frequency; Genetic Markers; Humans; Kinetics; Methemoglobinemia; Mutagens; Phenylthiourea; Polymorphism, Genetic; Porphyrias; Racial Groups; Superoxide Dismutase; Taste; Xanthine Oxidase	1986
Theophylline reassessed. Annals of internal medicine, 1984, Volume: 101, Issue:1 Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; Caffeine; Contraceptives, Oral; Cooking; Cystic Fibrosis; Drug Interactions; Erythromycin; Female; Heart Diseases; Histamine H2 Antagonists; Humans; Hypoxia; Infections; Kinetics; Liver Diseases; Lung Diseases, Obstructive; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Respiration Disorders; Sleep; Smoking; Theophylline	1984
The use of caffeine as a metabolic probe for human drug metabolizing enzymes. General pharmacology, 1996, Volume: 27, Issue:2 Topics: Acetyltransferases; Caffeine; Cytochrome P-450 Enzyme System; Humans; Xanthine Oxidase	1996
Catabolic pathways and biotechnological applications of microbial caffeine degradation. Biotechnology letters, 2006, Volume: 28, Issue:24 Topics: Bacterial Proteins; Caffeine; Cytochrome P-450 CYP1A2; Industrial Microbiology; Metabolic Networks and Pathways; Metabolism; Models, Biological; Oxidoreductases, N-Demethylating; Oxygenases; Pseudomonas; Xanthine Oxidase; Yeasts	2006
Caffeine metabolic ratios for the in vivo evaluation of CYP1A2, N-acetyltransferase 2, xanthine oxidase and CYP2A6 enzymatic activities. Current drug metabolism, 2009, Volume: 10, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Humans; Metabolic Networks and Pathways; Molecular Structure; Phenotype; Xanthine Oxidase	2009

Trials

14 trial(s) available for caffeine and allopurinol

Article	Year
Omeprazole treatment does not affect the metabolism of caffeine. Gastroenterology, 1991, Volume: 101, Issue:4 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Double-Blind Method; Enzyme Induction; Humans; Male; Omeprazole; Oxidoreductases; Xanthine Oxidase	1991
Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test. British journal of clinical pharmacology, 1994, Volume: 38, Issue:5 Topics: Administration, Oral; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Methylation; Oxidoreductases; Sweden; Xanthine Oxidase	1994
Determination of urinary metabolites of caffeine for the assessment of cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activity in humans. Therapeutic drug monitoring, 1996, Volume: 18, Issue:3 Topics: Acetyltransferases; Adolescent; Adult; Biotransformation; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Contraceptives, Oral, Hormonal; Cytochrome P-450 CYP1A2; Drug Interactions; Female; Humans; Male; Reproducibility of Results; Sex Characteristics; Smoking; Spectrophotometry, Ultraviolet; Xanthine Oxidase	1996
Absence of effect of terbinafine on the activity of CYP1A2, NAT-2, and xanthine oxidase. Journal of clinical pharmacology, 1998, Volume: 38, Issue:5 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Female; Humans; Male; Naphthalenes; Terbinafine; Xanthine Oxidase	1998
Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping. Clinical pharmacology and therapeutics, 1998, Volume: 63, Issue:5 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Menstrual Cycle; Sex Characteristics; Xanthine Oxidase	1998
Pantoprazole lacks induction of CYP1A2 activity in man. International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Area Under Curve; Benzimidazoles; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Cytochrome P-450 CYP1A2; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Humans; Male; Omeprazole; Pantoprazole; Proton Pump Inhibitors; Sulfoxides; Xanthine Oxidase	1999
Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail". Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:5 Topics: Acetyltransferases; Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Genotype; Humans; Midazolam; Middle Aged; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Phosphodiesterase Inhibitors; Reproducibility of Results; Vitamins; Warfarin; Xanthine Oxidase	2003
Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism. Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:5 Topics: Adult; Amino Acid Transport System A; Amino Acid Transport Systems; Area Under Curve; Caffeine; Carbon Monoxide; Carboxyhemoglobin; Carrier Proteins; Central Nervous System Stimulants; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Male; Middle Aged; Muscle Relaxants, Central; Smoking; Xanthine Oxidase	2003
The in-vivo effects of sho-saiko-to, a traditional Chinese herbal medicine, on two cytochrome P450 enzymes (1A2 and 3A) and xanthine oxidase in man. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:11 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Drugs, Chinese Herbal; Enzyme Activation; Female; Humans; Male; Oxidoreductases, N-Demethylating; Xanthine Oxidase	2003
Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail. Journal of clinical pharmacology, 2005, Volume: 45, Issue:12 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Contraceptives, Oral; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Genotype; Humans; Midazolam; Norgestrel; Omeprazole; Therapeutic Equivalency; Vitamin K; Warfarin; Xanthine Oxidase	2005
The effect of Shoseiryuto, a traditional Japanese medicine, on cytochrome P450s, N-acetyltransferase 2 and xanthine oxidase, in extensive or intermediate metabolizers of CYP2D6. European journal of clinical pharmacology, 2007, Volume: 63, Issue:4 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Drugs, Chinese Herbal; Female; Herb-Drug Interactions; Humans; Male; Xanthine Oxidase	2007
Reduction in non-glomerular renal clearance of the caffeine metabolite 1-methylxanthine by probenecid. International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:8 Topics: Adult; Area Under Curve; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Creatinine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Depression, Chemical; Double-Blind Method; Female; Humans; Kidney; Male; Probenecid; Renal Agents; Spectrophotometry, Ultraviolet; Xanthine Oxidase; Xanthines	2007
Genistein alters caffeine exposure in healthy female volunteers. European journal of clinical pharmacology, 2011, Volume: 67, Issue:4 Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Drug Interactions; Female; Genistein; Humans; Xanthine Oxidase	2011
A herbal-drug interaction study of keishi-bukuryo-gan, a traditional herbal preparation used for menopausal symptoms, in healthy female volunteers. The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:5 Topics: Acetyltransferases; Adult; Caffeine; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Drugs, Chinese Herbal; Estrogens; Female; Herb-Drug Interactions; Humans; Hydrocortisone; Menopause; Phenotype; Phytotherapy; Reference Values; Xanthine Oxidase; Young Adult	2012

Other Studies

85 other study(ies) available for caffeine and allopurinol

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogPoct: a tool for lipophilicity determination in drug discovery. Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Solvents	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments. ACS medicinal chemistry letters, 2022, Jul-14, Volume: 13, Issue:7 Topics:	2022
The human metabolism of caffeine to theophylline. Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:2 Topics: Allopurinol; Aminophylline; Biological Availability; Caffeine; Humans; Male; Theophylline; Time Factors	1976
Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis, 1992, Volume: 13, Issue:9 Topics: Acetylation; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Diet; Exercise; Female; Humans; Life Style; Longitudinal Studies; Male; Multivariate Analysis; Oxidoreductases; Vegetables; Xanthine Oxidase	1992
Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations. European journal of clinical pharmacology, 1992, Volume: 43, Issue:2 Topics: Adolescent; Adult; Age Factors; Allopurinol; Caffeine; Child; Cimetidine; Drug Interactions; Female; Humans; Kidney Failure, Chronic; Liver Cirrhosis; Male; Phenytoin; Smoking; Theophylline	1992
Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:6 Topics: Adolescent; Adult; Aging; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Child; Child, Preschool; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Oxidoreductases; Racial Groups; Reference Values; Sex Characteristics; Xanthine Oxidase	1992
Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:5 Pt 1 Topics: Adult; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Ethanol; Female; Humans; Longitudinal Studies; Male; Uracil; Xanthine Oxidase	1991
Cytochrome P450 IA2 activity in man measured by caffeine metabolism: effect of smoking, broccoli and exercise. Advances in experimental medicine and biology, 1991, Volume: 283 Topics: Arylamine N-Acetyltransferase; Caffeine; Contraceptives, Oral; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Diet; Exercise; Female; Humans; Male; Oxidoreductases; Pregnancy; Sex Factors; Smoking; Vegetables; Xanthine Oxidase	1991
Liver function assessment by drug metabolism. Pharmacotherapy, 1990, Volume: 10, Issue:4 Topics: Acetamides; Adult; Allopurinol; Aminopyrine; Caffeine; Half-Life; Humans; Indocyanine Green; Lidocaine; Liver; Liver Circulation; Liver Diseases; Liver Function Tests; Metabolic Clearance Rate; Middle Aged; Oxypurinol; Pyrimidines; Sorbitol	1990
Measurement of urinary caffeine metabolites reflecting the "in vivo" xanthine oxidase activity in premature infants with RDS and in hypoxic states of children. Biomedica biochimica acta, 1989, Volume: 48, Issue:2-3 Topics: Biomarkers; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature; Respiratory Distress Syndrome, Newborn; Uric Acid; Xanthine Oxidase	1989
Paraxanthine metabolism in humans: determination of metabolic partial clearances and effects of allopurinol and cimetidine. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:1 Topics: Acetylation; Adult; Allopurinol; Caffeine; Cimetidine; Cytochrome P-450 Enzyme System; Humans; Kidney; Male; Metabolic Clearance Rate; Theophylline	1989
Interaction of caffeine with acetaminophen in mice: schedule dependency of the antagonism by caffeine of acetaminophen hepatotoxicity and the effects of caffeine metabolites, allopurinol, and diethyl ether. Research communications in chemical pathology and pharmacology, 1988, Volume: 59, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Allopurinol; Animals; Biotransformation; Caffeine; Ethanol; Ether; Ethyl Ethers; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA	1988
Changes in theophylline metabolism during postnatal development in rat liver slices. Biochemical pharmacology, 1986, Sep-15, Volume: 35, Issue:18 Topics: Allopurinol; Animals; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Liver; Proadifen; Rats; Theobromine; Theophylline	1986
Effect of allopurinol on caffeine disposition in man. British journal of clinical pharmacology, 1986, Volume: 21, Issue:4 Topics: Adult; Allopurinol; Biotransformation; Caffeine; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Kidney; Kinetics; Male; Uric Acid; Xanthine Oxidase; Xanthines	1986
Variability of caffeine metabolism in humans. Arzneimittel-Forschung, 1985, Volume: 35, Issue:1A Topics: Acetylation; Biotransformation; Caffeine; Dealkylation; Female; Half-Life; Humans; Kinetics; Liver Diseases; Male; Phenotype; Pregnancy; Racial Groups; Smoking; Time Factors; Xanthine Oxidase	1985
Effects of 5-diazoimidazole-4-carboxamide and 3-diazopyrazole-4-carboxamide and related thioazo compounds on xanthine oxidase, uricase, and hypoxanthine-guanine phosphoriboxyltransferase. Biochemical pharmacology, 1972, Aug-01, Volume: 21, Issue:15 Topics: Allopurinol; Amides; Animals; Azides; Azo Compounds; Caffeine; Cattle; Diazonium Compounds; Imidazoles; Inosine Nucleotides; Mercaptopurine; Pentosephosphates; Pentosyltransferases; Pyrazoles; Rats; Structure-Activity Relationship; Triazenes; Urate Oxidase; Xanthine Oxidase	1972
Secretion of purines by the small intestine: general characteristics. The American journal of physiology, 1968, Volume: 215, Issue:4 Topics: Adenine; Allopurinol; Animals; Biological Transport; Caffeine; Carbon Isotopes; Chromatography, Paper; Cricetinae; Female; Hypoxanthines; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Methods; Nucleotides; Purines; Pyrimidines; Tritium; Uric Acid; Xanthine Oxidase	1968
Variability in caffeine metabolism. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:5 Topics: Acetyltransferases; Administration, Oral; Adolescent; Adult; Aged; Biotransformation; Caffeine; Canada; China; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxylation; Male; Middle Aged; Xanthine Oxidase	1983
Inhibitory effects of methylxanthines on the activity of xanthine oxidase. Life sciences, 1980, Dec-01, Volume: 27, Issue:22 Topics: Animals; Brain; Buffaloes; Caffeine; Female; In Vitro Techniques; Kidney; Kinetics; Lung; Milk; Myocardium; Rats; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase; Xanthines	1980
Caffeine metabolism in liver slices during postnatal development in the rat. Biochemical pharmacology, 1981, Dec-01, Volume: 30, Issue:23 Topics: Aging; Allopurinol; Animals; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; In Vitro Techniques; Kinetics; Liver; Proadifen; Rats	1981
Low CYP1A2 activity in rural Shona children of Zimbabwe. Clinical pharmacology and therapeutics, 1995, Volume: 57, Issue:1 Topics: Acetyltransferases; Adolescent; Adult; Caffeine; Canada; Child; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Humans; Liver; Male; Oxidoreductases; Rural Population; Urban Population; Xanthine Oxidase; Zimbabwe	1995
Caffeine phenotyping of cytochrome P4501A2, N-acetyltransferase, and xanthine oxidase in patients with familial adenomatous polyposis. Gut, 1995, Volume: 36, Issue:2 Topics: Acetyltransferases; Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Caffeine; Colectomy; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Oxidoreductases; Phenotype; Time Factors; Xanthine Oxidase	1995
Caffeine metabolism in cystic fibrosis: enhanced xanthine oxidase activity. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:5 Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Base Sequence; Caffeine; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cystic Fibrosis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Humans; Liver; Male; Mixed Function Oxygenases; Molecular Sequence Data; Oxidoreductases; Polymerase Chain Reaction; Xanthine Oxidase	1994
[A comparative study of the effect of allopurinol and caffeine on mitotic cycle recovery in cells after x-ray irradiation]. Tsitologiia, 1993, Volume: 35, Issue:11-12 Topics: Allopurinol; Caffeine; DNA; Dose-Response Relationship, Drug; Flow Cytometry; HeLa Cells; Humans; Mitosis; Radiation-Sensitizing Agents; Time Factors	1993
Oxidation of caffeine and related methylxanthines in ascorbate and polyphenol-driven Fenton-type oxidations. Free radical research, 1996, Volume: 24, Issue:3 Topics: Animals; Ascorbic Acid; Caffeine; Catalase; Cattle; Chromatography, High Pressure Liquid; Edetic Acid; Ferrous Compounds; Hydroxyl Radical; Kinetics; Liver; Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Phenols; Purines; Superoxide Dismutase; Xanthine; Xanthine Oxidase; Xanthines	1996
CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine. British journal of clinical pharmacology, 1996, Volume: 41, Issue:6 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dealkylation; Female; Humans; Male; Sex Factors; Smoking; Xanthine Oxidase	1996
Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes. The American journal of physiology, 1996, Volume: 271, Issue:3 Pt 2 Topics: Animals; Caffeine; Calcium; Carrier Proteins; Heart Ventricles; Hydrogen Peroxide; Myocardium; Patch-Clamp Techniques; Rabbits; Reactive Oxygen Species; Sarcoplasmic Reticulum; Sodium-Calcium Exchanger; Xanthine; Xanthine Oxidase; Xanthines	1996
Rate of caffeine metabolism and risk of spontaneous abortion. American journal of epidemiology, 1998, Mar-01, Volume: 147, Issue:5 Topics: Abortion, Spontaneous; Adult; Arylamine N-Acetyltransferase; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Female; Humans; Pregnancy; Pregnancy Outcome; Risk Factors; Xanthine Oxidase	1998
Analysis of urinary caffeine metabolites to assess biotransformation enzyme activities by reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1998, May-08, Volume: 709, Issue:1 Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Biotransformation; Caffeine; Child; Chromatography, High Pressure Liquid; Contraceptives, Oral; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Humans; Male; Mixed Function Oxygenases; Xanthine Oxidase	1998
Acetylation polymorphism expression in patients before and after liver transplantation: influence of host/graft genotypes. Pharmacogenetics, 1998, Volume: 8, Issue:3 Topics: Acetylation; Adult; Aged; Alleles; Arylamine N-Acetyltransferase; Caffeine; Female; Genotype; Humans; Liver Transplantation; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Transplantation Chimera; Xanthine Oxidase	1998
Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping. Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:3 Topics: Acetyltransferases; Adult; Anti-Anxiety Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Female; Fluvoxamine; Genotype; Humans; Hypnotics and Sedatives; Male; Midazolam; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Selective Serotonin Reuptake Inhibitors; Time Factors; Xanthine Oxidase	1998
Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities. European journal of clinical pharmacology, 1999, Volume: 54, Issue:11 Topics: Allopurinol; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Female; Humans; Male; Oxypurinol; Prospective Studies; Uric Acid; Xanthine Oxidase	1999
Purification and partial characterization of caffeine oxidase--A novel enzyme from a mixed culture consortium. Biochemical and biophysical research communications, 1999, Sep-24, Volume: 263, Issue:2 Topics: Caffeine; Klebsiella; Oxidation-Reduction; Oxygenases; Rhodococcus; Substrate Specificity; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase	1999
The caffeine metabolic ratio as an index of xanthine oxidase activity in clinically active and silent celiac patients. Journal of pediatric gastroenterology and nutrition, 1999, Volume: 29, Issue:5 Topics: Caffeine; Celiac Disease; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Iron; Male; Uric Acid; Xanthine Oxidase; Xanthines	1999
Effect of age and smoking on in vivo CYP1A2, flavin-containing monooxygenase, and xanthine oxidase activities in Koreans: determination by caffeine metabolism. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3 Topics: Adult; Aged; Aging; Asian People; Caffeine; Case-Control Studies; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Korea; Male; Middle Aged; Oxygenases; Reference Values; Smoking; Xanthine Oxidase	2000
Actions of reactive oxygen species on AH/type 2 myenteric neurons in guinea pig distal colon. American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:5 Topics: Action Potentials; Animals; Caffeine; Colon; Guinea Pigs; Hydrogen Peroxide; Hydroxyl Radical; Hypoxanthine; Male; Myenteric Plexus; Neurons; Oxidants; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Reactive Oxygen Species; Xanthine Oxidase	2000
Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail". Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:4 Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Anti-Ulcer Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Female; Genotype; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Polymerase Chain Reaction; Xanthine Oxidase	2000
Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects. Teratogenesis, carcinogenesis, and mutagenesis, 2001, Volume: 21, Issue:2 Topics: Acetaldehyde; Alcohol Drinking; Allopurinol; Animals; Antimetabolites; Caffeine; Carcinogens; Chromatography, Gas; Cytosol; Diet; Enzyme Inhibitors; Ethanol; Free Radicals; Gas Chromatography-Mass Spectrometry; Hypoxanthine; Male; Meat; NAD; Neoplasms; Niacinamide; Phosphodiesterase Inhibitors; Prostate; Prostatic Neoplasms; Purines; Rats; Rats, Sprague-Dawley; Spin Trapping; Temperature; Theobromine; Theophylline; Time Factors; Vasodilator Agents; Xanthine; Xanthine Oxidase	2001
Caffeine metabolism before and after liver transplantation. International journal of clinical pharmacology and therapeutics, 2001, Volume: 39, Issue:2 Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Azathioprine; Caffeine; Case-Control Studies; Cyclosporine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Humans; Immunosuppressive Agents; Liver; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Mixed Function Oxygenases; Reference Values; Uracil; Xanthine Oxidase	2001
Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment. Journal of chromatography. B, Biomedical sciences and applications, 2001, May-05, Volume: 755, Issue:1-2 Topics: Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Models, Chemical; Reproducibility of Results; Uracil; Xanthine Oxidase	2001
The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:2 Topics: Adult; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Postpartum Period; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Xanthine Oxidase	2001
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:11 Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	1997
Preliminary study of the vasorelaxant effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in rat aorta. Planta medica, 2001, Volume: 67, Issue:9 Topics: Animals; Aorta; Aporphines; Caffeine; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Papaveraceae; Plant Extracts; Rats; Rats, Wistar; Superoxides; Vasoconstriction; Vasodilation; Vasodilator Agents; Xanthine Oxidase	2001
A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2 Topics: Adult; Arylamine N-Acetyltransferase; Asian People; Caffeine; Cytochrome P-450 CYP1A2; Female; Genotype; Humans; Japan; Male; Phenotype; Reference Values; Uric Acid; Xanthine Oxidase	2002
Xanthine oxidase activity is influenced by environmental factors in Ethiopians. European journal of clinical pharmacology, 2003, Volume: 59, Issue:7 Topics: Black People; Caffeine; Environment; Ethiopia; Female; Genotype; Humans; Male; Phenotype; Polymorphism, Genetic; Sex Factors; Smoking; Sweden; Xanthine Oxidase	2003
Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females. British journal of clinical pharmacology, 2004, Volume: 57, Issue:4 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Humans; Hydrocortisone; Hypericum; Male; Middle Aged; Xanthine Oxidase	2004
Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children. Journal of clinical pharmacology, 2004, Volume: 44, Issue:7 Topics: Arylamine N-Acetyltransferase; Caffeine; Child; Child, Preschool; Cystic Fibrosis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Dextromethorphan; Female; Genotype; Humans; Male; Phenotype; Specimen Handling; Xanthine Oxidase	2004
Lack of effect of growth hormone replacement therapy on CYP1A2 and xanthine oxidase activities in growth hormone-deficient children. European journal of clinical pharmacology, 2006, Volume: 62, Issue:2 Topics: Adolescent; Biomarkers; Caffeine; Child; Child, Preschool; Cytochrome P-450 CYP1A2; Female; Hormone Replacement Therapy; Human Growth Hormone; Humans; Male; Recombinant Proteins; Xanthine Oxidase	2006
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomedical chromatography : BMC, 2007, Volume: 21, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	2007
Development of a biosensor for caffeine. Analytica chimica acta, 2007, Jan-23, Volume: 582, Issue:2 Topics: Biosensing Techniques; Caffeine; Calibration; Chromatography, High Pressure Liquid; Enzymes, Immobilized; Hydrogen-Ion Concentration; Pseudomonas alcaligenes; Sensitivity and Specificity; Temperature; Xanthine Oxidase	2007
Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement. Clinical therapeutics, 2008, Volume: 30, Issue:9 Topics: Adolescent; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Child; Child, Preschool; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Dextromethorphan; Dwarfism, Pituitary; Female; Growth Disorders; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Longitudinal Studies; Male; Phenotype; Prospective Studies; Recombinant Proteins; Xanthine Oxidase	2008
Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected? European journal of clinical pharmacology, 2009, Volume: 65, Issue:4 Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Humans; Male; Phenotype; Time Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines	2009
Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers. Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:8 Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Dose-Response Relationship, Drug; Drug Interactions; Humans; Inactivation, Metabolic; Male; Quercetin; Time Factors; Xanthine Oxidase; Young Adult	2009
Identification and fragmentation pathways of caffeine metabolites in urine samples via liquid chromatography with positive electrospray ionization coupled to a hybrid quadrupole linear ion trap (LTQ) and Fourier transform ion cyclotron resonance mass spec Rapid communications in mass spectrometry : RCM, 2009, Volume: 23, Issue:7 Topics: Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Female; Humans; Male; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry; Xanthine Oxidase	2009
Variability in drug metabolizing enzyme activity in HIV-infected patients. European journal of clinical pharmacology, 2010, Volume: 66, Issue:5 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; HIV Infections; Humans; Interleukin-6; Male; Midazolam; Phenotype; Tumor Necrosis Factor-alpha; Xanthine Oxidase	2010
In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population. European journal of clinical pharmacology, 2010, Volume: 66, Issue:6 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2A6; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Serbia; Smoking; White People; Xanthine Oxidase	2010
Redox modulation of diaphragm contractility: Interaction between DHPR and RyR channels. Free radical biology & medicine, 2010, Dec-15, Volume: 49, Issue:12 Topics: Animals; Antioxidants; Caffeine; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Diaphragm; Dithiothreitol; In Vitro Techniques; Male; Muscle Contraction; Nitrendipine; Organometallic Compounds; Oxidation-Reduction; Oxidative Stress; Procaine; Rats; Rats, Inbred F344; Reactive Oxygen Species; Reducing Agents; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Salicylates; Xanthine Oxidase	2010
Altered xanthine oxidase and N-acetyltransferase activity in obese children. British journal of clinical pharmacology, 2011, Volume: 72, Issue:1 Topics: Arylamine N-Acetyltransferase; Biomarkers; Body Weight; Caffeine; Case-Control Studies; Child; Cytochrome P-450 CYP1A2; Female; Humans; Male; Models, Statistical; Obesity; Xanthine Oxidase	2011
Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans. Journal of clinical pharmacology, 2012, Volume: 52, Issue:10 Topics: Arylamine N-Acetyltransferase; Asian People; Caffeine; Contraceptives, Oral; Genotype; Humans; Phenotype; Polymorphism, Single Nucleotide; Sex Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines	2012
Effects of Seijo-bofu-to, a traditional Japanese herbal medicine containing furanocoumarin derivatives, on the drug-metabolizing enzyme activities in healthy male volunteers. Basic & clinical pharmacology & toxicology, 2014, Volume: 115, Issue:4 Topics: Adult; Arylamine N-Acetyltransferase; Asian People; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Furocoumarins; Healthy Volunteers; Herb-Drug Interactions; Herbal Medicine; Humans; Hydrocortisone; Male; Medicine, Traditional; Phytotherapy; Plants, Medicinal; Xanthine Oxidase; Young Adult	2014
Distribution of xanthine oxidase activity in a Nigerian population. European journal of clinical pharmacology, 2015, Volume: 71, Issue:6 Topics: Adult; Black People; Caffeine; Female; Humans; Male; Phenotype; Polymorphism, Genetic; Xanthine Oxidase; Young Adult	2015
Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity. Oncotarget, 2015, Oct-06, Volume: 6, Issue:30 Topics: Angiogenic Proteins; Basophils; Caffeine; Cell Line, Tumor; Cell Lineage; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Glycolysis; Humans; Inflammation Mediators; Leukemia, Myeloid, Acute; Monocytes; Myeloid Cells; Signal Transduction; TOR Serine-Threonine Kinases; Xanthine Oxidase	2015
The Effect of Yokukansan, a Traditional Herbal Preparation Used for the Behavioral and Psychological Symptoms of Dementia, on the Drug-Metabolizing Enzyme Activities in Healthy Male Volunteers. Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:9 Topics: Adult; Arylamine N-Acetyltransferase; Behavior; Caffeine; Cytochrome P-450 Enzyme System; Dementia; Dextromethorphan; Drug Interactions; Drugs, Chinese Herbal; Healthy Volunteers; Humans; Hydrocortisone; Male; Middle Aged; Xanthine Oxidase	2016
Dietary effects of Sideritis scardica "mountain tea" on human in vivo activities of xenobiotic metabolizing enzymes in healthy subjects. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 122 Topics: Acetaminophen; Adult; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Dietary Exposure; Female; Glucuronosyltransferase; Healthy Volunteers; Herb-Drug Interactions; Humans; Male; Middle Aged; Plant Components, Aerial; Saliva; Sideritis; Substrate Specificity; Teas, Herbal; Xanthine Oxidase; Xenobiotics; Young Adult	2018
Determination of Urinary Caffeine Metabolites as Biomarkers for Drug Metabolic Enzyme Activities. Nutrients, 2019, Aug-19, Volume: 11, Issue:8 Topics: Adult; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Humans; Male; Middle Aged; Phenotype; Urinalysis; Xanthine Oxidase; Young Adult	2019
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial. Scientific reports, 2023, 06-10, Volume: 13, Issue:1 Topics: Allopurinol; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Injuries; Caffeine; Clemastine; Disease Models, Animal; Hedgehog Proteins; Humans; Hydroxybutyrates; Hypothermia, Induced; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Ischemia; Melatonin; Neuroprotective Agents; Rats	2023