caffeine and adenosine-5'-(n-ethylcarboxamide)

caffeine has been researched along with adenosine-5'-(n-ethylcarboxamide) in 73 studies

Research

Studies (73)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (27.40)	18.7374
1990's	30 (41.10)	18.2507
2000's	15 (20.55)	29.6817
2010's	7 (9.59)	24.3611
2020's	1 (1.37)	2.80

Authors

Authors	Studies
Jacobson, KA; van Galen, PJ; Williams, M	1
Browne, RG; Howard, HR; Koe, BK; Lebel, LA; Sarges, R; Seymour, PA	1
Daly, JW	1
Arslan, G; Fredholm, BB; Kull, B; Lorenzen, A; Nilsson, C; Owman, C; Schwabe, U	1
Borea, PA; Dalpiaz, A; Gilli, G; Gilli, P; Scatturin, A; Varani, K	1
Ishiyama, H; Kobayashi, J; Nakata, H; Ohshita, K; Oyanagi, K	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Abe, T; Ishiyama, H; Kobayashi, J; Nakata, H; Ohshita, K	1
Ishiyama, H; Kobayashi, J; Nakajima, H; Nakata, H	1
Bertarelli, DC; Borrmann, T; Florin, NC; Hinz, S; Li, W; Müller, CE; Scheiff, AB	1
Drabczyńska, A; Handzlik, J; Karcz, T; Karolak-Wojciechowska, J; Kieć-Kononowicz, K; Köse, M; Kuder, K; Müller, CE; Paskaleva, M; Schiedel, AC; Yuzlenko, O	1
Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L	1
de Lera Ruiz, M; Lim, YH; Zheng, J	1
Ahn, S; Cheong, JH; Jacobson, KA; Jeong, LS; Jin, SH; Kim, G; Kim, HJ; Kim, J; Lee, E; Lee, M; Noh, M; Yu, J	1
Berizzi, A; Bird, L; Culurgioni, S; Navratilova, IH; Olsen, RHJ; Rawlins, PB; Robinson, S; Shepherd, C; Thompson, LEJ; Varzandeh, S	1
Arizono, K; Brady, FO; Garrett, SH; Xiong, X	1
Huddart, H; Lynch, M	1
Nasir, T; Zarrindast, MR	1
Andén, NE; Casas, M; Ferré, S; Grabowska-Andén, M; Herrera-Marschitz, M; Ungerstedt, U	1
Holtzman, SG; Mante, S; Minneman, KP	1
Arzubiaga, C; Biaggioni, I; Paul, S; Puckett, A	1
Holtzman, SG	1
Seale, TW; Sekar, KC; Sheldon, RE; Toubas, PL	1
Brechler, V; Garbarz, E; Lotersztajn, S; Pavoine, C; Pecker, F	1
Elphick, M; Godfrey, PP; Powell, T; Taghavi, Z	1
Berman, RF; Lupica, CR; Rosen, JB; Whitcomb, K	1
Biaggioni, I; Feoktistov, I; Hollister, AS; Paul, S; Robertson, D	1
Durcan, MJ; Morgan, PF	1
Coffin, VL; Spealman, RD	2
Caporali, MG; Popoli, P; Scotti de Carolis, A	1
Clark, M; Post, RM	1
Sosnowski, M; Stevens, CW; Yaksh, TL	1
Phillis, JW	1
Daly, JW; Padgett, W; Shamim, MT; Ukena, D	1
Phillis, JW; Stair, RE	1
Spealman, RD	1
Abla, KA; Carney, JM; Daly, JW; Seale, TW; Shamim, MT	1
Giovannelli, L; Giovannini, MG; Pedata, F; Pepeu, G	1
Jarvis, MF; Williams, M	1
Dugich, MM; Hawkins, M; Porter, NM; Radulovacki, M; Urbancic, M	1
Goldberg, SR; Katz, JL; Prada, JA	1
Finn, IB; Holtzman, SG	1
Gutknecht, AM; Lozeman, FJ; Markovic, J; Stanley, JC	1
Barraco, RA; Campbell, WR; Phillis, JW; Shehin, SE; Stair, RE	1
Altman, HJ; Barraco, RA; Coffin, VL; Phillis, JW; Taylor, JA	1
Carney, JM; Logan, L	1
Schiffmann, SN; Vanderhaeghen, JJ	1
Behbehani, MM; Dollberg-Stolik, O	1
Daly, JW; Nikodijevic, O; Shi, D; Wong, V	1
Babey, AM; Palmour, RM; Young, SN	1
Shafaghi, B; Zarrindast, MR	1
Holtzman, SG; Woolfolk, DR	1
Biaggioni, I; Kurunwune, B; Paul, S	1
Howell, LL	1
Poon, A; Sawynok, J	1
Bauer, J; Berger, M; Biber, K; Fiebich, BL; Gyufko, K; van Calker, D	1
Jen, SC; Rovainen, CM	1
Newland, MC	1
Brown, K; Newland, MC	1
Belardinelli, L; Borea, PA; Merighi, S; Ongini, E; Portaluppi, F; Varani, K	1
Chrousos, GP; Crane, ML; Elenkov, IJ; Kino, T; Link, AA; McGuire, JL; Wilder, RL; Worth, JA	1
Borgeat, P; Bourgoin, SG; Harbour, D; Naccache, PH; Thibault, N	1
Belardinelli, L; Borea, PA; Gessi, S; Merighi, S; Ongini, E; Portaluppi, F; Varani, K	1
Green, TA; Schenk, S	1
Buggy, J; Davis, JM; Hand, GA; Mehl, KA; Stock, HS; Zhao, Z	1
Cohen, MV; Cui, L; Downey, JM; Krieg, T; Yang, XM	1
Belardinelli, L; Borea, PA; Bortolotti, F; Cattabriga, E; Dalpiaz, A; Gessi, S; Merighi, S; Portaluppi, F; Varani, K; Vincenzi, F	1
Batuca, JR; Conde, SV; Gonzalez, C; Monteiro, EC; Obeso, A	1
Burbiel, CE; Knittel, J; Müller, CE; Töpfer, M; Verspohl, EJ	1
Han, HJ; Kim, MO; Lee, YJ	1
Ciancetta, A; Moro, S; Sabbadin, D	1
Hasegawa, H; Zheng, X	1

Reviews

4 review(s) available for caffeine and adenosine-5'-(n-ethylcarboxamide)

Article	Year
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship	1992
Adenosine receptors: targets for future drugs. Journal of medicinal chemistry, 1982, Volume: 25, Issue:3 Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Ligands; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Xanthines	1982
Fluorescent ligands for adenosine receptors. Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1 Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1	2013
Adenosine A2A receptor as a drug discovery target. Journal of medicinal chemistry, 2014, May-08, Volume: 57, Issue:9 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Crystallography, X-Ray; Drug Discovery; Humans; Ligands; Protein Conformation; Receptor, Adenosine A2A; Signal Transduction	2014

Other Studies

69 other study(ies) available for caffeine and adenosine-5'-(n-ethylcarboxamide)

Article	Year
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants. Journal of medicinal chemistry, 1990, Volume: 33, Issue:8 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Cats; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Corpus Striatum; Male; Molecular Structure; Motor Activity; Purinergic Antagonists; Quinoxalines; Rats; Receptors, Purinergic; Sleep; Structure-Activity Relationship; Triazoles	1990
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochemical pharmacology, 1999, Jan-01, Volume: 57, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Humans; Kinetics; PC12 Cells; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Triazoles; Tritium	1999
Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors. Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6 Topics: Estradiol; Female; Humans; In Vitro Techniques; Male; Metribolone; Pregnenediones; Prostate; Receptors, Androgen; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Thermodynamics; Uterus	2005
Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors. Bioorganic & medicinal chemistry, 2007, May-01, Volume: 15, Issue:9 Topics: Binding Sites; Caffeine; Carbolines; Cell Line; Humans; Ligands; Molecular Structure; Receptors, Purinergic P1; Structure-Activity Relationship	2007
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Carbolines; Cell Line; Humans; Molecular Structure; Receptors, Purinergic P1; Structure-Activity Relationship	2008
Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors. Bioorganic & medicinal chemistry, 2009, Jul-01, Volume: 17, Issue:13 Topics: Binding, Competitive; Caffeine; Carbolines; Cell Line; Humans; Ligands; Protein Binding; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship	2009
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13 Topics: Adenosine A2 Receptor Antagonists; Animals; Drug Design; Humans; Kinetics; Ligands; Mice; Protein Binding; Radioligand Assay; Rats; Receptor, Adenosine A2B; Xanthines	2009
Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones. European journal of medicinal chemistry, 2011, Volume: 46, Issue:9 Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Cyclization; Humans; Hydrogen Bonding; Models, Molecular; Purines; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Receptor, Adenosine A1; Receptor, Adenosine A2A	2011
Polypharmacology of N Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals; Cell Line; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Male; Mice; Mice, Inbred C57BL; Polypharmacology; PPAR delta; PPAR gamma; Receptor, Adenosine A3	2017
Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments. ACS medicinal chemistry letters, 2022, Jul-14, Volume: 13, Issue:7 Topics:	2022
Purinergic agonist induction of metallothionein. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 201, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cells, Cultured; Cladribine; Deoxyadenosines; Dose-Response Relationship, Drug; Immunoblotting; Liver; Male; Metallothionein; Rats; Rats, Inbred Strains; RNA, Messenger; Theophylline; Time Factors; Transcription, Genetic; Vasodilator Agents	1992
Purinergic modulation of field stimulation responses of rat and human vas deferens smooth muscle. General pharmacology, 1991, Volume: 22, Issue:5 Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Electric Stimulation; Guanethidine; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Quinidine; Rats; Receptors, Purinergic; Theophylline; Urinary Bladder; Vas Deferens; Vasodilator Agents	1991
Methylxanthine-induced attenuation of pecking in chickens. British journal of pharmacology, 1991, Volume: 104, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Apomorphine; Behavior, Animal; Caffeine; Chickens; Dipyridamole; Female; Male; Theophylline; Xanthines	1991
Postsynaptic dopamine/adenosine interaction: II. Postsynaptic dopamine agonism and adenosine antagonism of methylxanthines in short-term reserpinized mice. European journal of pharmacology, 1991, Jan-03, Volume: 192, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bromocriptine; Caffeine; Dopamine; Male; Mice; Motor Activity; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Sulpiride; Synapses; Theophylline; Xanthines	1991
Role of adenosine receptors in caffeine tolerance. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Administration, Oral; Animals; Binding Sites; Brain; Caffeine; Cyclic AMP; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Male; Motor Activity; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Time Factors; Tritium; Xanthines	1991
Caffeine and theophylline as adenosine receptor antagonists in humans. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Caffeine; Heart Rate; Humans; Male; Platelet Aggregation; Purinergic Antagonists; Receptors, Purinergic; Substance Withdrawal Syndrome; Theophylline	1991
CGS 15943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant rats. Life sciences, 1991, Volume: 49, Issue:21 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Motor Activity; Quinazolines; Rats; Rats, Inbred Strains; Triazoles	1991
Fetal and newborn lambs differ in their cardiopulmonary responsiveness to adenosine agonists. Developmental pharmacology and therapeutics, 1990, Volume: 15, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Animals, Newborn; Blood Pressure; Bradycardia; Caffeine; Female; Heart; Heart Rate, Fetal; Hydrogen-Ion Concentration; Phenylisopropyladenosine; Pregnancy; Pulmonary Gas Exchange; Respiration; Sheep; Vasodilator Agents	1990
Activation of Na+/Ca2+ exchange by adenosine in ewe heart sarcolemma is mediated by a pertussis toxin-sensitive G protein. The Journal of biological chemistry, 1990, Oct-05, Volume: 265, Issue:28 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Calcium; Female; GTP-Binding Proteins; Guanosine; Heart Ventricles; Inosine; Kinetics; Myocardium; Pertussis Toxin; Phenylisopropyladenosine; Sarcolemma; Sheep; Sodium; Virulence Factors, Bordetella	1990
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948. Psychopharmacology, 1990, Volume: 100, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines	1990
Adenosine involvement in postictal events in amygdala-kindled rats. Epilepsy research, 1990, Volume: 6, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amygdala; Animals; Anticonvulsants; Caffeine; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Kindling, Neurologic; Male; Rats; Seizures; Theophylline; Time Factors	1990
Adenosine inhibits the rise in intracellular calcium and platelet aggregation produced by thrombin: evidence that both effects are coupled to adenylate cyclase. Molecular pharmacology, 1990, Volume: 37, Issue:6 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Caffeine; Calcium; Cytosol; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Xanthines	1990
Caffeine-induced seizures: apparent proconvulsant action of N-ethyl carboxamidoadenosine (NECA). Life sciences, 1990, Volume: 47, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Caffeine; Cerebral Ventricles; Dose-Response Relationship, Drug; Male; Mice; Premedication; Receptors, Purinergic; Regression Analysis; Seizures	1990
Modulation of the behavioral effects of chlordiazepoxide by methylxanthines and analogs of adenosine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Chlordiazepoxide; Conditioning, Psychological; Male; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Saimiri; Theobromine; Theophylline; Xanthines	1985
The role of the purinergic system in the control of stereotypy: relationship to D-1/D-2 dopamine receptor activity. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzazepines; Caffeine; Carbamazepine; Dopamine Antagonists; Drug Interactions; Electroencephalography; Haloperidol; Male; Rabbits; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Purinergic; Stereotyped Behavior	1989
Carbamazepine, but not caffeine, is highly selective for adenosine A1 binding sites. European journal of pharmacology, 1989, May-19, Volume: 164, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Carbamazepine; Cerebellum; Corpus Striatum; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic	1989
Assessment of the role of A1/A2 adenosine receptors mediating the purine antinociception, motor and autonomic function in the rat spinal cord. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Autonomic Nervous System; Blood Pressure; Caffeine; Male; Movement; Pain; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Spinal Cord; Urinary Bladder	1989
Chlorpromazine and trifluoperazine potentiate the action of adenosine on rat cerebral cortical neurons. General pharmacology, 1985, Volume: 16, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cerebral Cortex; Chlorpromazine; Depression, Chemical; Drug Synergism; Iontophoresis; Male; Rats; Rats, Inbred Strains; Synaptic Transmission; Synaptosomes; Trifluoperazine; Vasodilator Agents	1985
Analogs of caffeine: antagonists with selectivity for A2 adenosine receptors. Life sciences, 1986, Aug-25, Volume: 39, Issue:8 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Caffeine; Humans; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship	1986
Ro 15-1788 both antagonizes and potentiates adenosine-evoked depression of cerebral cortical neurons. European journal of pharmacology, 1987, Apr-14, Volume: 136, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cerebral Cortex; Evoked Potentials; Flumazenil; Male; Rats; Rats, Inbred Strains	1987
Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism. Psychopharmacology, 1988, Volume: 95, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Male; Psychomotor Performance; Receptors, Purinergic; Saimiri; Stimulation, Chemical; Theophylline; Xanthines	1988
3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs. Life sciences, 1988, Volume: 43, Issue:21 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Body Temperature; Caffeine; Male; Mice; Mice, Inbred DBA; Motor Activity; Reference Values; Theobromine; Theophylline	1988
Purinergic modulation of cortical acetylcholine release is decreased in aging rats. Experimental gerontology, 1988, Volume: 23, Issue:3 Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Caffeine; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Parietal Lobe; Rats; Rats, Inbred Strains	1988
Differences in adenosine A-1 and A-2 receptor density revealed by autoradiography in methylxanthine-sensitive and insensitive mice. Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Autoradiography; Brain; Caffeine; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Organ Specificity; Receptors, Purinergic; Species Specificity; Tritium	1988
Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain. Brain research bulletin, 1988, Volume: 21, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Caffeine; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic	1988
Effects of adenosine analogs alone and in combination with caffeine in the squirrel monkey. Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Caffeine; Conditioning, Operant; Drug Interactions; Male; Motor Activity; Phenylisopropyladenosine; Receptors, Purinergic; Saimiri	1988
Tolerance and cross-tolerance to theophylline-induced stimulation of locomotor activity in rats. Life sciences, 1988, Volume: 42, Issue:24 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Dextroamphetamine; Drug Tolerance; Male; Motor Activity; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Theophylline	1988
Stimulation of glycogenolysis in isolated hepatocytes by adenosine and one of its analogues is inhibited by caffeine. The Biochemical journal, 1987, Nov-01, Volume: 247, Issue:3 Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cell Separation; Dose-Response Relationship, Drug; Enzyme Activation; Glucagon; In Vitro Techniques; Liver; Liver Glycogen; Male; Phenylisopropyladenosine; Phosphorylases; Rats; Rats, Inbred Strains; Stimulation, Chemical	1987
Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Blood Pressure; Caffeine; Cardiovascular System; Clonidine; Cocaine; Dextroamphetamine; Heart Rate; Isomerism; Macaca fascicularis; Male; Phenylisopropyladenosine	1987
Central effects of adenosine analogs on blood pressure and heart rate in the mouse. The Canadian journal of cardiology, 1987, Volume: 3, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Phenylisopropyladenosine	1987
Behavioral interaction of adenosine and methylxanthines on central purinergic systems. Neuroscience letters, 1984, Jun-15, Volume: 47, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Caffeine; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity; Papaverine; Theophylline	1984
Antagonism of the behavioral effects of L-phenylisopropyladenosine (L-PIA) by caffeine and its metabolites. Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Conditioning, Psychological; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Theophylline; Xanthines	1984
Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Corpus Striatum; Enkephalins; Gene Expression Regulation; Globus Pallidus; Neurons; Oxidopamine; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Purinergic; Substance P; Substantia Nigra	1993
Partial sciatic nerve ligation results in an enlargement of the receptive field and enhancement of the response of dorsal horn neurons to noxious stimulation by an adenosine agonist. Pain, 1994, Volume: 58, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Caffeine; Causalgia; Electrophysiology; Hyperalgesia; Male; Neurons; Nociceptors; Pain Measurement; Patch-Clamp Techniques; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Stimulation, Chemical; Vasodilator Agents	1994
Chronic effects of ethanol on central adenosine function of mice. Brain research, 1994, Jul-04, Volume: 650, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Caffeine; Ethanol; Male; Mice; Motor Activity; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Time Factors	1994
Caffeine and propranolol block the increase in rat pineal melatonin production produced by stimulation of adenosine receptors. Neuroscience letters, 1994, Jul-18, Volume: 176, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Binding, Competitive; Caffeine; Caudate Nucleus; Circadian Rhythm; Male; Melatonin; Pineal Gland; Propranolol; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Vasodilator Agents	1994
Effects of adenosine receptor agonists and antagonists on acquisition of passive avoidance learning. European journal of pharmacology, 1994, May-02, Volume: 256, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Avoidance Learning; Caffeine; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Male; Mice; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Theophylline; Vasodilator Agents	1994
Restraint stress potentiates analgesia induced by 5'-N-ethylcarboxamidoadenosine: comparison with morphine. European journal of pharmacology, 1993, Aug-03, Volume: 239, Issue:1-3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesia; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Restraint, Physical; Stress, Physiological	1993
Caffeine withdrawal: apparent heterologous sensitization to adenosine and prostacyclin actions in human platelets. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adolescent; Adult; Alprostadil; Blood Platelets; Caffeine; Epoprostenol; Humans; Male; Models, Biological; Purinergic P1 Receptor Antagonists; Receptors, Epoprostenol; Receptors, Prostaglandin; Receptors, Purinergic P1; Sensitivity and Specificity; Substance Withdrawal Syndrome; Up-Regulation	1993
Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Carbon Dioxide; Female; Hypercapnia; Hypoxia; Macaca mulatta; Male; Oxygen; Phenethylamines; Plethysmography; Pyrrolidinones; Receptors, Purinergic; Respiration; Respiratory Function Tests; Rolipram	1993
Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration. European journal of pharmacology, 1995, Nov-14, Volume: 286, Issue:2 Topics: Adenosine; Adenosine Kinase; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Caffeine; Deoxyadenosines; Enzyme Inhibitors; Formaldehyde; Male; Pentostatin; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1	1995
Adenosine A2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells. Journal of neurochemistry, 1996, Volume: 66, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Antineoplastic Agents; Astrocytoma; Blotting, Northern; Caffeine; Dose-Response Relationship, Immunologic; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; RNA, Messenger; Stereoisomerism; Tumor Cells, Cultured; Xanthines	1996
An adenosine agonist increases blood flow and density of capillary branches in the optic tectum of Xenopus laevis tadpoles. Microcirculation (New York, N.Y. : 1994), 1994, Volume: 1, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Capillaries; Microcirculation; Microscopy, Video; Neovascularization, Physiologic; Nitroglycerin; Regional Blood Flow; Superior Colliculi; Theophylline; Time Factors; Vasodilator Agents; Xenopus laevis	1994
Quantifying the molecular structure of behavior: separate effects of caffeine, cocaine, and adenosine agonists on interresponse times and lever-press durations. Behavioural pharmacology, 1997, Volume: 8, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Phenylisopropyladenosine; Rats; Reaction Time; Reinforcement Schedule; Time Factors; Vasodilator Agents	1997
Behavioral characterization of caffeine and adenosine agonists during chronic caffeine exposure. Behavioural pharmacology, 1997, Volume: 8, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Phenylisopropyladenosine; Rats	1997
Caffeine alters A2A adenosine receptors and their function in human platelets. Circulation, 1999, May-18, Volume: 99, Issue:19 Topics: Adenosine-5'-(N-ethylcarboxamide); Adult; Blood Platelets; Caffeine; Cyclic AMP; Female; Humans; Male; Middle Aged; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P1; Signal Transduction	1999
Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes. Journal of immunology (Baltimore, Md. : 1950), 2000, Jan-01, Volume: 164, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Caffeine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Immunologic; Female; Humans; Immunosuppressive Agents; Interleukin-10; Interleukin-12; Ligands; Lipopolysaccharides; Male; Monocytes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Signal Transduction	2000
Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases. Blood, 2000, Jan-15, Volume: 95, Issue:2 Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); ADP-Ribosylation Factor 1; Adult; Caffeine; Cell Membrane; Enzyme Activation; GTP Phosphohydrolases; Humans; In Vitro Techniques; Isoenzymes; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenethylamines; Phospholipase D; Protein Kinase C; Protein Kinase C-alpha; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; rhoA GTP-Binding Protein; Triazoles	2000
Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors : functional and biochemical aspects. Circulation, 2000, Jul-18, Volume: 102, Issue:3 Topics: Adenosine-5'-(N-ethylcarboxamide); Adult; Blood Platelets; Caffeine; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Myocardium; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Time Factors; Triazoles; Up-Regulation	2000
Dopaminergic mechanism for caffeine-produced cocaine seeking in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 26, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzazepines; Caffeine; Central Nervous System Stimulants; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Motor Activity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Salicylamides; Self Administration; Theophylline; Vasodilator Agents	2002
Central nervous system effects of caffeine and adenosine on fatigue. American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 284, Issue:2 Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Central Nervous System; Fatigue; Injections, Intraventricular; Male; Motor Activity; Muscle Fatigue; Rats; Rats, Wistar; Receptors, Purinergic P1	2003
NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO. Journal of molecular and cellular cardiology, 2004, Volume: 36, Issue:3 Topics: Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Androstadienes; Animals; Bradykinin; Caffeine; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Infarction; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rabbits; Receptors, Adenosine A2; Reperfusion; Signal Transduction; Vasodilator Agents; Wortmannin	2004
Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors. Cellular and molecular life sciences : CMLS, 2005, Volume: 62, Issue:19-20 Topics: Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Adult; Caffeine; Cells, Cultured; Cyclic AMP; Humans; Male; Neutrophils; Receptor, Adenosine A2A; Superoxides	2005
An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells. Journal of neurochemistry, 2008, Volume: 107, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; Acetamides; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Carotid Body; Catecholamines; Chemoreceptor Cells; Cyclic AMP; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Oxygen; Phenethylamines; Phosphodiesterase Inhibitors; Purines; Rats; Rats, Wistar; Receptor, Adenosine A2B; Receptors, Dopamine D2; Tritium; Vasodilator Agents	2008
Modulation of insulin release by adenosine A1 receptor agonists and antagonists in INS-1 cells: the possible contribution of 86Rb+ efflux and 45Ca2+ uptake. Cell biochemistry and function, 2008, Volume: 26, Issue:8 Topics: 3T3-L1 Cells; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Antineoplastic Agents; Caffeine; Calcium; Calcium Channels; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Insulin; Mice; Potassium Channels; Rats; Rats, Wistar; Receptor, Adenosine A1; Rubidium; Xanthines	2008
Involvement of Cx43 phosphorylation in 5'-N-ethylcarboxamide-induced migration and proliferation of mouse embryonic stem cells. Journal of cellular physiology, 2010, Volume: 224, Issue:1 Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cell Line; Cell Movement; Cell Proliferation; Connexin 43; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Dose-Response Relationship, Drug; Embryonic Stem Cells; Focal Adhesion Kinase 1; Gap Junctions; Integrin beta1; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; src-Family Kinases; Time Factors	2010
Bridging molecular docking to membrane molecular dynamics to investigate GPCR-ligand recognition: the human A₂A adenosine receptor as a key study. Journal of chemical information and modeling, 2014, Jan-27, Volume: 54, Issue:1 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Algorithms; Binding Sites; Caffeine; Computational Biology; Computer Simulation; Crystallography, X-Ray; Humans; Ligands; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Receptor, Adenosine A2A; Static Electricity; Structural Homology, Protein	2014
Administration of caffeine inhibited adenosine receptor agonist-induced decreases in motor performance, thermoregulation, and brain neurotransmitter release in exercising rats. Pharmacology, biochemistry, and behavior, 2016, Volume: 140 Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Body Temperature; Body Temperature Regulation; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Dopamine; Male; Motor Activity; Neurotransmitter Agents; Oxygen Consumption; Physical Conditioning, Animal; Physical Endurance; Psychomotor Performance; Rats; Rats, Wistar; Receptors, Purinergic P1	2016