caffeine has been researched along with 8-(3-chlorostyryl)caffeine in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (30.67) | 18.2507 |
| 2000's | 42 (56.00) | 29.6817 |
| 2010's | 10 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jacobson, KA; Ji, XD; Kim, HO; Melman, N; Olah, ME; Stiles, GL | 1 |
| Frobenius, W; Geis, U; Hipp, J; Müller, CE; Pawłowski, M; Sandoval-Ramírez, J; Schobert, U; Suzuki, F | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bergh, JJ; Castagnoli, N; Edmondson, DE; Malan, SF; Milczek, EM; Petzer, JP; Van der Walt, EM | 1 |
| Akkari, R; Borrmann, T; Brunschweiger, A; Drabczyńska, A; Hockemeyer, J; Kieć-Kononowicz, K; Koch, P; Köse, M; Küppers, P; Müller, CE; Radjainia, H; Schlenk, M | 1 |
| Carradori, S; Silvestri, R | 1 |
| Terre'Blanche, G; Van der Walt, MM | 1 |
| Hinz, S; Karcz, T; Kieć-Kononowicz, K; Kubas, B; Kuder, K; Latacz, G; Müller, CE; Olejarz-Maciej, A; Schabikowski, J; Schlenk, M; Synak, D; Załuski, M; Zygmunt, M | 1 |
| Danhof, M; Gubbens-Stibbe, JM; Ijzerman, AP; Jacobson, KA; Mathôt, RA; Soudijn, W | 1 |
| Daly, JW; Gallo-Rodriguez, C; Jacobson, KA; Maillard, M; Nikodijević, O; Padgett, WL | 1 |
| Fink, JS; Pollack, AE | 1 |
| Bauer, J; Berger, M; Biber, K; Fiebich, BL; Gyufko, K; van Calker, D | 1 |
| Chern, Y; Ching, YH; Lai, HL; Lee, EH; Lee, YC; Wang, HL | 1 |
| Breimer, DD; Danhof, M; Ijzerman, AP; Mathoôt, RA; Soudijn, W | 1 |
| Phillis, JW | 1 |
| Jacobson, KA; Lin, RC; Von Lubitz, DK | 1 |
| Eigler, A; Endres, S; Greten, TF; Haslberger, C; Sinha, B; Sullivan, GW | 1 |
| Albin, RL; Frey, KA; Kearney, JA | 1 |
| Chang, YH; Chern, Y; Ching, YH; Conti, M; Lai, HL; Lee, YC | 1 |
| Cunha, RA; Gonçalves, ML; Ribeiro, JA | 1 |
| Khandwala, H; Loomis, CW; Zhang, Z | 1 |
| Assmann, H; Illes, P; Nörenberg, W; Richter, M; Wirkner, K | 1 |
| Jennings, NM; Li, B; Maxwell, KM; Rosenbaum, PS; Roth, S | 1 |
| Dorsa, DM; Ward, RP | 1 |
| Balkay, L; Boros, I; Emri, M; Fekete, I; Horváth, G; Lengyel, Z; Márián, T; Sarkadi, E; Szentmiklósi, AJ; Trón, L | 1 |
| Adair, TH; Anand, V; Brady, AL; Gu, JW; Kelly, WC; Moore, MC | 1 |
| Fredholm, BB; Lindström, K | 1 |
| Mahy, N; Robledo, P; Ursu, G | 1 |
| Baldo, BA; Koob, GF; Markou, A | 1 |
| Chrousos, GP; Crane, ML; Elenkov, IJ; Kino, T; Link, AA; McGuire, JL; Wilder, RL; Worth, JA | 1 |
| Borgeat, P; Bourgoin, SG; Harbour, D; Naccache, PH; Thibault, N | 1 |
| Dunwiddie, TV; Thümmler, S | 1 |
| Li, SN; Wong, PT | 1 |
| Dixon, AK; Freeman, TC; Lee, K; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Chilian, WM; Jones, DW; Merkus, D; Nishikawa, Y; Stepp, DW | 1 |
| O'Kane, EM; Stone, TW | 1 |
| Beilstein, MA; Chen, JF; Cuellar, B; Fink, JS; Grandy, DK; Hackett, E; Impagnatiello, F; Low, MJ; Moratalla, R; Ongini, E; Rubinstein, M; Schwarzschild, MA | 1 |
| Chung, ES; Dobson, JG; Fenton, RA; Lorbar, M; Meyer, TE; Norton, GR; Perlini, S; Woodiwiss, AJ | 1 |
| Emala, CW; Lee, HT | 1 |
| Grbović, L; Pesić, S; Prostran, M; Radenković, M | 1 |
| Baier, S; Falk, W; Günzler, C; Kees, F; Michna, A; Pongratz, G; Schölmerich, J; Straub, RH | 1 |
| Flood, AJ; Headrick, JP; Willems, L | 1 |
| Balkay, L; Boros, I; Fekete, I; Horváth, G; Lengyel, Z; Márián, T; Szentmiklósi, AJ | 1 |
| Castagnoli, K; Castagnoli, N; Chen, JF; Petzer, JP; Schwarzschild, MA; Sonsalla, PK; Staal, R; Steyn, S; Van Der Schyf, CJ; Xu, K | 1 |
| Bonastre, M; Bové, J; Marin, C; Tolosa, E | 1 |
| Blay, J; Butler, JJ; Hoskin, DW; Mader, JS; Watson, CL; Zhang, H | 1 |
| Berrino, L; Capuano, A; De Novellis, V; Filippelli, A; Mazzeo, F; Rossi, F; Stella, L; Vitelli, MR | 1 |
| Chen, JF; Ferrante, RJ; Fink, JS; Kalda, A; Ryu, H; Schwarzschild, MA; Stack, EC | 1 |
| Dziubina, A; Gołembiowska, K | 3 |
| Bremer, HC; Elsner, P; Girolomoni, G; Herouy, Y; Idzko, M; Mockenhaupt, M; Norgauer, J; Panther, E; Sorichter, S; Windisch, W | 1 |
| Cohen, MV; Cui, L; Downey, JM; Krieg, T; Yang, XM | 1 |
| Goto, W; Hirao, M; Ikeda, T; Kobayashi, T; Oku, H; Sugiyama, T | 1 |
| Bové, J; Cortés, R; Marin, C; Mengod, G; Serrats, J; Tolosa, E | 1 |
| Kogi, K; Konno, T; Nagai, A; Nakahata, N; Uchibori, T | 2 |
| Cohen, MV; Downey, JM; Solenkova, NV; Solodushko, V | 1 |
| Fischer, W; Franke, H; Gröger-Arndt, H; Günther, A; Illes, P; Köfalvi, A; Madarász, E; Nörenberg, W; Schneider, D; Sperlágh, B; Vizi, ES; Wirkner, K | 1 |
| Holý, A; Kmonícková, E; Potmesil, P; Zídek, Z | 1 |
| Bergh, JJ; Castagnoli, N; Malan, SF; Petzer, JP; Vlok, N | 1 |
| Aguilar, E; Bové, J; Cortés, R; Marin, C; Mengod, G; Serrats, J | 1 |
| Holý, A; Kmonícková, E; Krecmerová, M; Potmesil, P; Zídek, Z | 1 |
| Gu, R; Li, W; Shan, H; Wang, J; Wang, WH; Xu, Y; Yang, B; Zhang, Y | 1 |
| Furukawa, K; Ishii, N; Kataoka, K; Nagao, K; Tsuru, H | 1 |
| Aguiar, LM; de Sousa, FC; Macêdo, DS; Oliveira, AA; Vasconcelos, SM; Viana, GS | 1 |
| Akgun, A; Gidener, S; Hocaoglu, N; Kalkan, S; Tuncok, Y | 1 |
| Chae, JS; Jeong, JH; Kim, AY; Kim, HC; Kim, SC; Kim, WK; Ko, KH; Koh, YH; Nah, SY; Shin, EJ; Yen, TP; Yoon, HJ | 1 |
| Koh, HC; Lee, CB | 1 |
| Ba, M; Kong, M; Liu, Z; Ma, Y; Song, L | 1 |
| Chen, JF; Herm, L; Kalda, A; Rinken, A; Zharkovsky, A | 1 |
| Rose'Meyer, RB | 1 |
| Hu, WD; Huang, YX; Li, D; Liu, CF; Luo, WF | 1 |
| Bartoccini, F; Borsini, F; Cabri, W; Diamantini, G; Minetti, P; Mor, M; Pala, D; Piersanti, G; Riccioni, T; Rivara, S; Stasi, MA; Tarzia, G | 1 |
| Baumann, F; Boltze, J; Deten, A; Fronz, U; Härtig, W; Kranz, A; Nieber, K; Wagner, DC; Weidlich, S | 1 |
75 other study(ies) available for caffeine and 8-(3-chlorostyryl)caffeine
| Article | Year |
|---|---|
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Brain Chemistry; Caffeine; CHO Cells; Cricetinae; Gene Expression; Iodine Radioisotopes; Molecular Structure; Phenethylamines; Phenylisopropyladenosine; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Transfection; Xanthines | 1994 |
Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists.
Topics: Adenosine; Animals; Binding, Competitive; Brain; Caffeine; Molecular Structure; Phenethylamines; Protein Binding; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theobromine; Xanthines | 1997 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Inhibition of monoamine oxidase by (E)-styrylisatin analogues.
Topics: Binding, Competitive; Brain; Chemistry, Pharmaceutical; Drug Design; Humans; Inhibitory Concentration 50; Isatin; Kinetics; Models, Chemical; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutation; Structure-Activity Relationship | 2009 |
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; CHO Cells; Cricetulus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Purinergic P1 Receptor Antagonists; Purines; Xanthines | 2013 |
New Frontiers in Selective Human MAO-B Inhibitors.
Topics: Humans; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Polymorphism, Genetic; Protein Conformation; Structure-Activity Relationship | 2015 |
1,3,7-Triethyl-substituted xanthines--possess nanomolar affinity for the adenosine A1 receptor.
Topics: Adenosine A1 Receptor Antagonists; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Binding; Receptor, Adenosine A1; Structure-Activity Relationship; Xanthines | 2015 |
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.
Topics: Adenosine A2 Receptor Antagonists; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Receptor, Adenosine A2A; Structure-Activity Relationship; Xanthine | 2019 |
Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Caffeine; Drug Evaluation, Preclinical; Drug Interactions; Heart Rate; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats | 1995 |
8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Caffeine; Locomotion; Male; Mice; Rats | 1993 |
Adenosine antagonists potentiate D2 dopamine-dependent activation of Fos in the striatopallidal pathway.
Topics: Adenosine; Adrenergic Uptake Inhibitors; Animals; Caffeine; Dopamine Agonists; Ergolines; Genes, fos; Globus Pallidus; Immunohistochemistry; Male; Neostriatum; Neural Pathways; Phosphodiesterase Inhibitors; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Reserpine; Theobromine; Theophylline | 1995 |
Adenosine A2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Antineoplastic Agents; Astrocytoma; Blotting, Northern; Caffeine; Dose-Response Relationship, Immunologic; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; RNA, Messenger; Stereoisomerism; Tumor Cells, Cultured; Xanthines | 1996 |
Circadian rhythm in the Ca(2+)-inhibitable adenylyl activity of the rat striatum.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Caffeine; Calcium; Circadian Rhythm; Colforsin; Corpus Striatum; Cyclic AMP; Guanosine Diphosphate; Isoenzymes; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley | 1996 |
Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo.
Topics: 2-Chloroadenosine; Animals; Caffeine; Hemodynamics; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline | 1996 |
The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil.
Topics: Animals; Behavior, Animal; Caffeine; Carotid Arteries; Cerebral Cortex; Cerebrovascular Disorders; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Locomotion; Male; Purinergic P1 Receptor Antagonists; Pyrazines; Reperfusion Injury; Xanthines | 1995 |
Cerebral ischemia in gerbils: effects of acute and chronic treatment with adenosine A2A receptor agonist and antagonist.
Topics: Adenosine; Animals; Brain Ischemia; Caffeine; Cell Survival; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models, Animal; Female; Gerbillinae; Hippocampus; Laser-Doppler Flowmetry; Neurons; Phenethylamines; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Treatment Outcome | 1995 |
Endogenous adenosine curtails lipopolysaccharide-stimulated tumour necrosis factor synthesis.
Topics: Adenosine; Adenosine Deaminase; Caffeine; Dipyridamole; Humans; Inosine; Leukocytes, Mononuclear; Lipopolysaccharides; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Pyrrolidinones; Rolipram; Tumor Necrosis Factor-alpha; Xanthines | 1997 |
Metabotropic glutamate agonist-induced rotation: a pharmacological, FOS immunohistochemical, and [14C]-2-deoxyglucose autoradiographic study.
Topics: Animals; Autoradiography; Basal Ganglia; Behavior, Animal; Caffeine; Carbon Radioisotopes; Cycloleucine; Deoxyglucose; Dopamine; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Glucose; Glycine; Immunohistochemistry; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Receptors, Purinergic P1; Resorcinols; Rotation; Salicylamides; Thalamic Nuclei; Xanthines | 1997 |
Activation of phosphodiesterase IV during desensitization of the A2A adenosine receptor-mediated cyclic AMP response in rat pheochromocytoma (PC12) cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adrenal Gland Neoplasms; Animals; Blotting, Western; Caffeine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activation; Enzyme Inhibitors; Isoquinolines; Kinetics; PC12 Cells; Phenethylamines; Pheochromocytoma; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Recombinant Proteins; Sulfonamides | 1997 |
Adenosine A2A receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes.
Topics: 2-Chloroadenosine; Adenosine; Animals; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Hippocampus; Male; omega-Agatoxin IVA; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Spider Venoms; Synaptosomes; Veratridine; Xanthines | 1997 |
Inhibition of strychnine-allodynia is mediated by spinal adenosine A1- but not A2-receptors in the rat.
Topics: Adenosine; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Spinal; Male; Pain; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Strychnine; Xanthines | 1998 |
Adenosine A2A receptors inhibit the conductance of NMDA receptor channels in rat neostriatal neurons.
Topics: Adenosine; Adenylyl Cyclases; Animals; Caffeine; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Neostriatum; Neurons; Patch-Clamp Techniques; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Signal Transduction; Theophylline | 1998 |
Differing roles of adenosine receptor subtypes in retinal ischemia-reperfusion injury in the rat.
Topics: Animals; Caffeine; Electroretinography; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Reperfusion Injury; Retina; Time Factors; Xanthines | 1999 |
Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotonin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration.
Topics: Adenosine; Animals; Antipsychotic Agents; Behavior, Animal; Caffeine; Catalepsy; Clozapine; Corpus Striatum; Cyclic AMP; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Genes, fos; GTP-Binding Protein alpha Subunits, Gs; Haloperidol; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Second Messenger Systems; Serotonin; Serotonin Antagonists; Theophylline | 1999 |
Preparation and primary evaluation of [11C]CSC as a possible tracer for mapping adenosine A2A receptors by PET.
Topics: Animals; Autoradiography; Caffeine; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Isotope Labeling; Male; Mice; Purinergic P1 Receptor Antagonists; Rabbits; Radioligand Assay; Radiopharmaceuticals; Receptor, Adenosine A2A; Receptors, Purinergic P1; Tissue Distribution; Tomography, Emission-Computed | 1999 |
Adenosine upregulates VEGF expression in cultured myocardial vascular smooth muscle cells.
Topics: Adenosine; Animals; Caffeine; Cell Hypoxia; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Endothelial Growth Factors; Lymphokines; Male; Muscle, Smooth, Vascular; Myocardium; Reference Values; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines | 1999 |
Effects of adenosine and gamma-aminobutyric acid A receptor antagonists on N-methyl-D-aspartate induced neurotoxicity in the rat hippocampus.
Topics: Animals; Atrophy; Caffeine; Functional Laterality; GABA-A Receptor Antagonists; Hippocampus; Male; Microinjections; N-Methylaspartate; Neurons; Neurotoxins; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Xanthines | 1999 |
Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats.
Topics: Adenosine; Animals; Brain; Caffeine; Cocaine; Differential Threshold; Dopamine Uptake Inhibitors; Drug Interactions; Electric Stimulation; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Reaction Time; Receptors, Purinergic P1; Reference Values; Reward; Substance Withdrawal Syndrome; Theobromine | 1999 |
Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Caffeine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Immunologic; Female; Humans; Immunosuppressive Agents; Interleukin-10; Interleukin-12; Ligands; Lipopolysaccharides; Male; Monocytes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Signal Transduction | 2000 |
Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases.
Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); ADP-Ribosylation Factor 1; Adult; Caffeine; Cell Membrane; Enzyme Activation; GTP Phosphohydrolases; Humans; In Vitro Techniques; Isoenzymes; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenethylamines; Phospholipase D; Protein Kinase C; Protein Kinase C-alpha; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; rhoA GTP-Binding Protein; Triazoles | 2000 |
Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic Antagonists; Animals; Caffeine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Periodicity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Theophylline; Xanthines | 2000 |
The adenosine receptor agonist, APNEA, increases calcium influx into rat cortical synaptosomes through N-type channels associated with A2a receptors.
Topics: Adenosine; Animals; Brain Chemistry; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Cerebral Cortex; Dose-Response Relationship, Drug; Male; omega-Conotoxin GVIA; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Synaptosomes; Xanthines | 2000 |
Adenosine receptor expression and function in rat striatal cholinergic interneurons.
Topics: Acetylcholine; Adenosine; Adenosine Deaminase; Animals; Baclofen; Bicuculline; Caffeine; Cholinergic Fibers; Corpus Striatum; Dose-Response Relationship, Drug; GABA Antagonists; Gene Expression; Male; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Tritium; Xanthines | 2000 |
Adenosine preconditions against endothelin-induced constriction of coronary arterioles.
Topics: Adenosine; Animals; Arterioles; Caffeine; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelin-1; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Microcirculation; Purinergic P1 Receptor Antagonists; Vasoconstriction; Vasodilation; Vasodilator Agents; Xanthines | 2000 |
Characterisation of ATP-induced facilitation of transmission in rat hippocampus.
Topics: Adenosine Deaminase; Adenosine Triphosphate; Animals; Caffeine; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Purinergic P1 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Wistar; Suramin; Synaptic Transmission; Theophylline | 2000 |
The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice.
Topics: Adenosine; Amphetamines; Animals; Caffeine; Catalepsy; Corpus Striatum; Dopamine Antagonists; Enkephalins; Gene Expression; Haloperidol; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Purinergic P1; RNA, Messenger | 2001 |
Antiadrenergic effects of adenosine in pressure overload hypertrophy.
Topics: Adenosine; Adrenergic Antagonists; Adrenergic beta-Agonists; Animals; Blood Pressure; Body Weight; Caffeine; Calcium; Cardiomegaly; Cells, Cultured; Coronary Circulation; Disease Models, Animal; Echocardiography; In Vitro Techniques; Inosine; Isoproterenol; Male; Myocardial Contraction; Myocardium; Organ Size; Perfusion; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley | 2001 |
Systemic adenosine given after ischemia protects renal function via A(2a) adenosine receptor activation.
Topics: Adenosine; Analysis of Variance; Animals; Bucladesine; Caffeine; Kidney; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Reperfusion Injury; Vasodilation; Xanthines | 2001 |
Characterization of adenosine action in isolated rat renal artery. Possible role of adenosine A(2A) receptors.
Topics: Adenosine; Animals; Caffeine; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Indomethacin; Isotonic Solutions; Male; Models, Animal; Muscle Relaxation; Nitroarginine; Potassium Chloride; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Renal Artery; Tetraethylammonium; Vasodilator Agents; Xanthines | 2000 |
Immunoregulation of IL-6 secretion by endogenous and exogenous adenosine and by exogenous purinergic agonists in splenic tissue slices.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Caffeine; Electric Stimulation; Female; In Vitro Techniques; Interleukin-6; Macrophages; Mice; Mice, Inbred Strains; Neuroimmunomodulation; Norepinephrine; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Spleen; Sympathetic Nervous System; Thionucleotides | 2002 |
Coronary function and adenosine receptor-mediated responses in ischemic-reperfused mouse heart.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Diphosphate; Animals; Caffeine; Coronary Circulation; Heart; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocardial Contraction; Myocardial Reperfusion Injury; Nitroprusside; Perfusion; Phenethylamines; Purinergic P1 Receptor Antagonists; Vasodilator Agents; Xanthines | 2002 |
[In vivo investigation of the A2A adenosine receptor distribution using the [11C]-CSC radioligand].
Topics: Animals; Autoradiography; Brain; Caffeine; Carbon Radioisotopes; Cell Line; Isotope Labeling; Kidney; Liver; Lung; Mice; Muscle, Smooth; Rabbits; Radioligand Assay; Radiopharmaceuticals; Receptor, Adenosine A2A; Receptors, Purinergic P1; Tissue Distribution; Tomography, Emission-Computed; Urinary Bladder | 2002 |
8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Caffeine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Neurons; Receptor, Adenosine A2A; Receptors, Purinergic P1; Time Factors | 2002 |
Adenosine A2A antagonism reverses levodopa-induced motor alterations in hemiparkinsonian rats.
Topics: Animals; Caffeine; Levodopa; Male; Motor Activity; Parkinsonian Disorders; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1 | 2002 |
Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.
Topics: Adenosine; Animals; Antibodies, Monoclonal; Caffeine; CD2 Antigens; CD28 Antigens; CD3 Complex; Cell Cycle; Colforsin; Cyclic AMP; Female; Flavins; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Phenethylamines; Receptors, Interleukin-2; Receptors, Purinergic P1; Signal Transduction; T-Lymphocytes; Tyrosine | 2003 |
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Chromatography, High Pressure Liquid; Dopamine; Injections, Subcutaneous; Male; Microdialysis; Morphine; Pyrimidines; Rats; Rats, Wistar; Receptors, Dopamine; Substance Withdrawal Syndrome; Triazoles | 2003 |
Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Corpus Striatum; Female; Gene Silencing; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitro Compounds; Propionates; Receptor, Adenosine A2A | 2004 |
Effect of the adenosine A2A receptor antagonist 8-(3-chlorostyryl)caffeine on L-DOPA biotransformation in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Benserazide; Brain Chemistry; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Male; Microdialysis; Rats; Rats, Wistar; Reserpine | 2004 |
Inosine stimulates chemotaxis, Ca2+-transients and actin polymerization in immature human dendritic cells via a pertussis toxin-sensitive mechanism independent of adenosine receptors.
Topics: Actins; Antigens, CD; Caffeine; Calcium; Cell Differentiation; Chemotaxis; Cytokines; Dendritic Cells; Dose-Response Relationship, Drug; Flow Cytometry; Histocompatibility Antigens Class I; Humans; Inosine; Pertussis Toxin; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Triazoles; Xanthines | 2004 |
NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.
Topics: Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Androstadienes; Animals; Bradykinin; Caffeine; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Infarction; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rabbits; Receptors, Adenosine A2; Reperfusion; Signal Transduction; Vasodilator Agents; Wortmannin | 2004 |
Effects of adenosine on optic nerve head circulation in rabbits.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine A1 Receptor Antagonists; Adenylyl Cyclase Inhibitors; Animals; Caffeine; Capillaries; Dose-Response Relationship, Drug; Glyburide; Injections; Injections, Intravenous; Optic Disk; Phenethylamines; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rabbits; Regional Blood Flow; Stimulation, Chemical; Vasodilation; Vitreous Body; Xanthines | 2004 |
Neuroprotection induced by the adenosine A2A antagonist CSC in the 6-OHDA rat model of parkinsonism: effect on the activity of striatal output pathways.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cell Count; Dynorphins; Enkephalins; Globus Pallidus; Immunohistochemistry; In Situ Hybridization; Male; Microinjections; Neostriatum; Neural Pathways; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; RNA, Messenger; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2005 |
2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Alkynes; Animals; Antihypertensive Agents; Caffeine; Decanoic Acids; Glyburide; Hydroxy Acids; Hypotonic Solutions; Intraocular Pressure; Male; Ocular Hypertension; Phenethylamines; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits; Receptor, Adenosine A2A; Sodium Chloride; Time Factors; Xanthines | 2005 |
Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt.
Topics: Acetamides; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Androstadienes; Animals; Butadienes; Caffeine; Female; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Antagonists; Purines; Rabbits; Receptors, Purinergic P1; Theophylline; Wortmannin; Xanthines | 2006 |
Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Anesthetics, Local; Animals; Bicuculline; Caffeine; Calcium; Cell Count; Cells, Cultured; Cerebral Cortex; Deoxyadenosines; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fura-2; GABA Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Immunohistochemistry; In Vitro Techniques; Ischemia; Membrane Potentials; Microscopy, Confocal; Microtubule-Associated Proteins; Neurons; Patch-Clamp Techniques; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrodotoxin; Time Factors; Triazines; Tritium; Xanthines | 2005 |
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
Topics: 2-Aminopurine; Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Caffeine; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Dihydropyridines; Dose-Response Relationship, Drug; Female; Flavins; Humans; Interleukin-10; Lipopolysaccharides; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Molecular Structure; Organophosphonates; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Triazoles; Tumor Necrosis Factor-alpha | 2006 |
Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC).
Topics: Adenosine A2 Receptor Antagonists; Animals; Binding, Competitive; Caffeine; Liver; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship; Stereoisomerism | 2006 |
Reversion of levodopa-induced motor fluctuations by the A2A antagonist CSC is associated with an increase in striatal preprodynorphin mRNA expression in 6-OHDA-lesioned rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic Agents; Animals; Caffeine; Corpus Striatum; Dynorphins; Dyskinesias; Enkephalins; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger | 2006 |
Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives.
Topics: Adenine; Animals; Caffeine; Cell Survival; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Female; Gene Expression; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles | 2006 |
Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Eye; Flavins; Intraocular Pressure; Male; Rabbits; Regional Blood Flow; Retinal Vessels; Vasodilator Agents; Xanthines | 2007 |
Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenylyl Cyclases; Algorithms; Animals; Bucladesine; Caffeine; Dose-Response Relationship, Drug; Enzyme Activation; Female; Kidney; Male; Patch-Clamp Techniques; Phenethylamines; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Adenosine A2; Stimulation, Chemical; Xanthines | 2007 |
The participation of adenosine receptors in the adenosine 5'-triphosphate-induced relaxation in the isolated rabbit corpus cavernosum penis.
Topics: Acetamides; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Animals; Caffeine; Flavins; Male; Muscle Relaxation; Muscle, Smooth; Penile Erection; Penis; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Purines; Rabbits; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Receptors, Purinergic P2 | 2007 |
CSC, an adenosine A(2A) receptor antagonist and MAO B inhibitor, reverses behavior, monoamine neurotransmission, and amino acid alterations in the 6-OHDA-lesioned rats.
Topics: Adenosine A2 Receptor Agonists; Animals; Behavior, Animal; Biogenic Monoamines; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Lipid Peroxidation; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neostriatum; Neuroprotective Agents; Nitrites; Norepinephrine; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Receptors, Adenosine A2; Rotation; Serotonin | 2008 |
Effects of adenosine receptor antagonists on amitriptyline-induced QRS prolongation in isolated rat hearts.
Topics: Amitriptyline; Animals; Caffeine; Dose-Response Relationship, Drug; Heart; Heart Diseases; In Vitro Techniques; Male; Purinergic P1 Receptor Antagonists; Random Allocation; Rats; Rats, Wistar; Xanthines | 2008 |
Ginsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A(2A) receptors in rat hippocampus.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Ginsenosides; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Seizures; Statistics, Nonparametric; Synaptosomes | 2009 |
Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Aminoquinolines; Anesthesia, Inhalation; Animals; Blood Pressure; Bradycardia; Caffeine; Glipizide; Guanylate Cyclase; Heart Rate; Hypothalamus, Posterior; Imines; KATP Channels; Male; Microinjections; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A | 2009 |
Inhibitory effect of 8-(3-chlorostryryl) caffeine on levodopa-induced motor fluctuation is associated with intracellular signaling pathway in 6-OHDA-lesioned rats.
Topics: Adenosine A2 Receptor Agonists; Animals; Antiparkinson Agents; Caffeine; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Levodopa; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Motor Activity; Movement; Oxidopamine; Parkinson Disease, Secondary; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Signal Transduction; Up-Regulation | 2009 |
Co-administration of the partial dopamine D2 agonist terguride with L-dopa attenuates L-dopa-induced locomotor sensitization in hemiparkinsonian mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Benzazepines; Caffeine; Corpus Striatum; Dopamine Agonists; Drug Therapy, Combination; Guanosine 5'-O-(3-Thiotriphosphate); Levodopa; Lisuride; Male; Mice; Mice, Inbred C57BL; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Random Allocation; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulfur Radioisotopes | 2009 |
Adenosine receptor interactions alter cardiac contractility in rat heart.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Caffeine; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flavins; Imines; In Vitro Techniques; Male; Myocardial Contraction; Phenylisopropyladenosine; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Stimulation, Chemical | 2010 |
CSC counteracts l-DOPA-induced overactivity of the corticostriatal synaptic ultrastructure and function in 6-OHDA-lesioned rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Blotting, Western; Brain; Caffeine; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Levodopa; Male; Microscopy, Electron, Transmission; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Synapses | 2011 |
Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Benserazide; Caffeine; Dopamine; Glutamic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles | 2012 |
The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Oxidative Stress; Rats; Rats, Wistar; Reserpine; Triazines; Triazoles; Vesicular Monoamine Transport Proteins | 2012 |
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.
Topics: Caffeine; HEK293 Cells; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase Inhibitors; Xanthines | 2013 |
Continuous adenosine A2A receptor antagonism after focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain; Brain Ischemia; Caffeine; Infarction, Middle Cerebral Artery; Male; Rats; Rats, Inbred SHR | 2014 |