caffeine and 7-hydroxystaurosporine

caffeine has been researched along with 7-hydroxystaurosporine in 16 studies

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (81.25)	29.6817
2010's	3 (18.75)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Stark, GR; Taylor, WR	1
Feijoo, C; Gilbert, DM; Hall-Jackson, C; Jenkins, D; Leitch, J; Smythe, C; Wu, R	1
Faller, DV; Guo, N; Vaziri, C	1
Friedrich, TD; Lehman, JM; Okubo, E	1
Pruschy, M; Tenzer, A	1
Hu, B; Iliakis, G; Khadpe, J; Wang, X; Wang, Y	1
Asaka, M; Chiba, K; Hashino, S; Imamura, M; Kato, N; Kobayashi, M; Kondo, T; Minami, Y; Minamino, N; Onozawa, M; Suzuki, S; Tanaka, J; Yokoyama, A	1
Cejka, P; Di Pietro, M; Ferrari, S; Jiricny, J; Marra, G; Mojas, N; Stojic, L	1
Desai, AB; Jacobberger, JW; Kinsella, TJ; Loh, T; Sramkoski, RM; Yan, T	1
Stern, DF; Tsvetkov, L	1
Bartek, J; Fugger, K; Hansen, LT; Helleday, T; Johansson, F; Lukas, J; Lundin, C; Sehested, M; Syljuåsen, RG; Sørensen, CS	1
Cai, Q; Fan, ST; Lao, X; Redpath, JL; Stanbridge, EJ; Wang, XQ	1
Kwak, S; Theurkauf, WE; Varmark, H	1
Blain, SW; Ye, W	1
Agarwal, A; Agarwal, M; Agarwal, MK; Chakrabarti, A; Glick, A; Gupta, K; Sharma, JP; Wald, DN; Yang, J; Zhang, Y	1

Reviews

2 review(s) available for caffeine and 7-hydroxystaurosporine

Article	Year
Regulation of the G2/M transition by p53. Oncogene, 2001, Apr-05, Volume: 20, Issue:15 Topics: 14-3-3 Proteins; Alkaloids; Animals; Biomarkers, Tumor; Caffeine; CDC2 Protein Kinase; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Exonucleases; Exoribonucleases; G2 Phase; Humans; Mitosis; Neoplasm Proteins; Phosphorylation; Proteins; Staurosporine; Tumor Suppressor Protein p53	2001
Potentiation of DNA-damage-induced cytotoxicity by G2 checkpoint abrogators. Current medicinal chemistry. Anti-cancer agents, 2003, Volume: 3, Issue:1 Topics: Alkaloids; Animals; Antineoplastic Agents; Caffeine; Cell Cycle Proteins; Cell Survival; Combined Modality Therapy; DNA Damage; Drug Synergism; G2 Phase; Humans; Staurosporine; Xanthines	2003

Article

Year

Regulation of the G2/M transition by p53.

Oncogene, 2001, Apr-05, Volume: 20, Issue:15

Topics: 14-3-3 Proteins; Alkaloids; Animals; Biomarkers, Tumor; Caffeine; CDC2 Protein Kinase; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Exonucleases; Exoribonucleases; G2 Phase; Humans; Mitosis; Neoplasm Proteins; Phosphorylation; Proteins; Staurosporine; Tumor Suppressor Protein p53

2001

Potentiation of DNA-damage-induced cytotoxicity by G2 checkpoint abrogators.

Current medicinal chemistry. Anti-cancer agents, 2003, Volume: 3, Issue:1

Topics: Alkaloids; Animals; Antineoplastic Agents; Caffeine; Cell Cycle Proteins; Cell Survival; Combined Modality Therapy; DNA Damage; Drug Synergism; G2 Phase; Humans; Staurosporine; Xanthines

2003

Other Studies

14 other study(ies) available for caffeine and 7-hydroxystaurosporine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. The Journal of cell biology, 2001, Sep-03, Volume: 154, Issue:5 Topics: Alkaloids; Animals; Aphidicolin; Ataxia Telangiectasia; Caffeine; Cell Fractionation; Cell Line; Cell Separation; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Replication; Enzyme Inhibitors; Flow Cytometry; Humans; Hydroxyurea; Immunoblotting; Microscopy, Fluorescence; Nucleic Acid Synthesis Inhibitors; Phosphodiesterase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Radiation, Ionizing; Replication Origin; S Phase; Staurosporine	2001
Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 2002, Volume: 13, Issue:2 Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenoviridae; Alkaloids; Antineoplastic Agents; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Caffeine; Carcinogens; CDC2-CDC28 Kinases; Cell Cycle Proteins; Checkpoint Kinase 1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; DNA Replication; DNA-Binding Proteins; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Humans; Immunoblotting; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Proteins	2002
Negative regulation of mitotic promoting factor by the checkpoint kinase chk1 in simian virus 40 lytic infection. Journal of virology, 2003, Volume: 77, Issue:2 Topics: Alkaloids; Animals; Caffeine; Cell Line; Checkpoint Kinase 1; Chlorocebus aethiops; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Mitosis; Nocodazole; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Simian virus 40; Staurosporine; Viral Proteins	2003
An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells. The Journal of biological chemistry, 2003, Aug-15, Volume: 278, Issue:33 Topics: Alkaloids; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Cell Line, Transformed; Cell Survival; Checkpoint Kinase 1; Enzyme Inhibitors; Fibroblasts; G2 Phase; Humans; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Radiation, Ionizing; RNA, Small Interfering; Staurosporine	2003
Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex. The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26 Topics: Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; DNA Damage; DNA Replication; Enzyme Inhibitors; HeLa Cells; Humans; Infrared Rays; Leupeptins; Phosphorylation; Recombinant Proteins; S-Phase Kinase-Associated Proteins; Staurosporine; Ubiquitin; Ultraviolet Rays	2004
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes & development, 2004, Jun-01, Volume: 18, Issue:11 Topics: Ataxia Telangiectasia Mutated Proteins; Base Pair Mismatch; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line; Checkpoint Kinase 1; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; Histones; Humans; Methylation; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Replication Protein A; Signal Transduction; Staurosporine; Tumor Suppressor Proteins	2004
CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. Molecular cancer therapeutics, 2004, Volume: 3, Issue:9 Topics: Antimetabolites, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Base Pair Mismatch; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; Colorectal Neoplasms; DNA Repair; DNA-Binding Proteins; Humans; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering; Staurosporine; Thioguanine; Tumor Suppressor Proteins	2004
Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage. Cell cycle (Georgetown, Tex.), 2005, Volume: 4, Issue:1 Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; Cyclin B; DNA Damage; DNA-Binding Proteins; Doxorubicin; Enzyme Activation; G2 Phase; Humans; Mitosis; Nocodazole; Phosphorylation; Polo-Like Kinase 1; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Serine; Signal Transduction; Staurosporine; Threonine; Tumor Suppressor Proteins	2005
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Molecular and cellular biology, 2005, Volume: 25, Issue:9 Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Checkpoint Kinase 1; Checkpoint Kinase 2; Chromosomal Proteins, Non-Histone; DNA Damage; DNA Replication; DNA-Binding Proteins; DNA, Single-Stranded; Histones; Humans; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Replication Protein A; RNA, Small Interfering; Roscovitine; Staurosporine; Tumor Suppressor Protein p53	2005
p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest. Radiation research, 2007, Volume: 168, Issue:6 Topics: Caffeine; cdc25 Phosphatases; Cell Line; Checkpoint Kinase 1; Checkpoint Kinase 2; Down-Regulation; G2 Phase; Humans; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Staurosporine; Tumor Suppressor Protein p53	2007
A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells. Cell cycle (Georgetown, Tex.), 2010, Jan-15, Volume: 9, Issue:2 Topics: Animals; Caffeine; Checkpoint Kinase 1; Checkpoint Kinase 2; Colorectal Neoplasms; DNA Breaks, Double-Stranded; DNA Damage; Drosophila; G2 Phase; Gene Knockout Techniques; HCT116 Cells; Humans; Mitosis; Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine	2010
Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage. Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:5 Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caffeine; Camptothecin; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebral Cortex; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Female; Genes, p53; Genomic Instability; Neurons; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Suppressor Proteins	2011
ATP depletion triggers acute myeloid leukemia differentiation through an ATR/Chk1 protein-dependent and p53 protein-independent pathway. The Journal of biological chemistry, 2012, Jul-06, Volume: 287, Issue:28 Topics: Acute Disease; Adenosine; Adenosine Triphosphate; Antibiotics, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Comet Assay; DNA Damage; Doxorubicin; HEK293 Cells; Humans; Leukemia, Myeloid; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine; Thioinosine; Tumor Suppressor Protein p53	2012