caffeine has been researched along with 3-methylcholanthrene in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (48.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Katz, ML; Kazmer, S; Weinstein, D | 1 |
| Casto, BC; Dipaolo, JA; Janosko, N; Pieczynski, WJ | 1 |
| Aldridge, A; Neims, AH; Parsons, WD | 1 |
| Ishikawa, A; Kobayashi, S; Misawa, S; Tanaka, E; Uchida, E; Yamamoto, Y; Yasuhara, H | 1 |
| de la Torre, R; Segura, J; Valero, F | 1 |
| Billion-Rey, F; Brazier, JL; Guilluy, R | 1 |
| Berthou, F; Dreano, Y; Guillouzo, A; Mondine, P; Ratanasavanh, D; Riche, C | 1 |
| Kalhorn, TF; Lee, CA; Nelson, SD; Slattery, JT | 1 |
| Abbruzzi, R; Bastone, A; Bianchi, M; Bonati, M; Catalani, P; Guaitani, A; Latini, R; Pantarotto, C; Szczawinska, K | 1 |
| Brodie, BB; Davis, DC; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ | 1 |
| Page, JG; Vesell, ES | 1 |
| Lombrozo, L; Mitoma, C | 1 |
| Craig, RL; O'Brien, RL; Stanton, R | 1 |
| Belvedere, G; Bonati, M; Celardo, A; Galletti, F; Latini, R; Tursi, F | 1 |
| Arnaud, MJ; Bircher, J; Preisig, R; Voegelin, M; Wietholtz, H | 1 |
| Belvedere, G; Bonati, M; Cantoni, R; Latini, R; Marzi, E | 1 |
| Czok, G | 1 |
| Furuya, KN; Kalow, W; Roberts, EA; Tang, BK | 1 |
| Cha, YN; Chung, WG; Kim, HM; Roh, HK | 1 |
| Fujita, S; Funae, Y; Imaoka, S; Kazusaka, A; Maeda, Y; Masuda, M; Morita, K | 1 |
| Horsmans, Y; Spatzenegger, M; Verbeeck, RK | 1 |
| Hattori, K; Iizasa, H; Kizu, J; Matsunaga, N; Nakashima, E; Takanaka, A | 1 |
| Choi, S; Nishikawa, M; Sakai, Y; Sakoda, A | 1 |
25 other study(ies) available for caffeine and 3-methylcholanthrene
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Chromosomal effects of carcinogens and non-carcinogens on WI-38 after short term exposures with and without metabolic activation.
Topics: 4-Nitroquinoline-1-oxide; Benzopyrenes; Caffeine; Cell Line; Chromosome Aberrations; Chromosomes; Diploidy; Fibroblasts; Methylcholanthrene; Methylnitronitrosoguanidine; Nitroquinolines; Pyrenes | 1977 |
Significance of treatment interval and DNA repair in the enhancement of viral transformation by chemical carcinogens and mutagens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetoxyacetylaminofluorene; Adenoviridae; Aflatoxins; Benzopyrenes; Caffeine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cytarabine; DNA Repair; DNA Replication; Methyl Methanesulfonate; Methylcholanthrene; Methylnitronitrosoguanidine; Mutagens; Oncogenic Viruses; Propiolactone | 1976 |
Stimulation of caffeine metabolism in the rat by 3-methylcholanthrene.
Topics: Animals; Caffeine; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats; Stimulation, Chemical; Time Factors | 1977 |
A simplified approach for evaluation of hepatic drug-oxidizing activity with a simultaneous determination of caffeine and trimethadione and their demethylated metabolites in rats with a selective cytochrome P-450 inducer.
Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Humans; Liver; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Trimethadione | 1992 |
Selective in-vitro inhibition of hepatic oxidative metabolism by quinolones: 7-ethoxyresorufin and caffeine as model substrates.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Caffeine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxazines; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Inbred Strains | 1991 |
On-line measurements of 13C enrichments in rat breath. Non-invasive method for in vivo study of drug enzymatic induction.
Topics: Animals; Breath Tests; Caffeine; Carbon Dioxide; Carbon Isotopes; Cytochrome P-450 Enzyme System; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats | 1991 |
Methylcholanthrene but not phenobarbital enhances caffeine and theophylline metabolism in cultured adult human hepatocytes.
Topics: Adult; Biotransformation; Caffeine; Cells, Cultured; Humans; Kinetics; Liver; Methylcholanthrene; Phenobarbital; Theophylline | 1990 |
Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Body Temperature; Caffeine; Glutathione; Imines; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1990 |
Metabolism of caffeine to 6-amino-5-[N-methylformylamino]-1,3-dimethyluracil in the isolated, perfused liver from control or phenobarbital-, beta-naphthoflavone- and 3-methylcholanthrene-pretreated rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Drug Interactions; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Uracil | 1987 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium | 1973 |
Genetic control of dicumarol levels in man.
Topics: Adult; Antipyrine; Caffeine; Centrifugation; Coffee; Dicumarol; Female; Genetics, Medical; Humans; Male; Methylcholanthrene; Middle Aged; Nicotine; Phenylbutazone; Pregnancy; Prothrombin Time; Smoking; Spectrophotometry; Twins | 1968 |
Effect of caffeine on hepatic microsomal cytochrome P-450.
Topics: Acetanilides; Adrenalectomy; Animals; Anisoles; Caffeine; Cytochromes; Enzyme Induction; Hydrogen-Ion Concentration; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitriles; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry; Sulfites; Time Factors | 1970 |
Chromatin binding of benzo(a)pyrene and 20-methylcholanthrene.
Topics: Animals; Benzopyrenes; Caffeine; Chromosomes; Dialysis; Fluorometry; Histones; Hot Temperature; Liver; Male; Methylcholanthrene; Nucleic Acid Denaturation; Rats; Spectrum Analysis; Templates, Genetic; Tritium | 1969 |
Kinetics of caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats | 1984 |
Assessment of the cytochrome P-448 dependent liver enzyme system by a caffeine breath test.
Topics: Adult; Animals; Breath Tests; Caffeine; Carbon Dioxide; Carbon Radioisotopes; Cytochrome P-450 CYP1A2; Cytochromes; Dealkylation; Enzyme Induction; Humans; Liver; Liver Cirrhosis; Male; Methylcholanthrene; Middle Aged; Phenobarbital; Rats; Rats, Inbred Strains; Tobacco Use Disorder | 1981 |
[2-14C]caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes by high pressure liquid chromatography.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Rats | 1980 |
[Reciprocal action between caffeine, other stimulants and drugs].
Topics: Analgesics; Animals; Barbiturates; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Ethanol; Humans; Methylcholanthrene; Nicotinic Acids; Phenobarbital; Smoking; Theobromine; Xanthines | 1980 |
Caffeine biotransformation in human hepatocyte lines derived from normal liver tissue.
Topics: Adult; Animals; Benz(a)Anthracenes; Biotransformation; Caffeine; Cell Line; Chlorocebus aethiops; Culture Techniques; Cytochrome P-450 Enzyme System; Humans; Kinetics; Liver; Methylcholanthrene; Reference Values; Transfection; Tumor Cells, Cultured | 1994 |
Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Hydroxylation; In Vitro Techniques; Male; Methylation; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Rats; Rats, Sprague-Dawley; Testosterone; Thioamides | 1998 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Dexamethasone; Female; Humans; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Sex Characteristics; Species Specificity; Troleandomycin; Uric Acid | 1998 |
Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Intestine, Small; Ketoconazole; Liver; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Wistar; Theobromine; Theophylline | 2000 |
Application of the PKCYP-test in cases of altered CYP1A2 for multiple CYP systems in rat models of disease.
Topics: Acetanilides; Aging; Algorithms; Animals; Antibodies, Blocking; Caffeine; Central Nervous System Stimulants; Choline Deficiency; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diet; Disease Models, Animal; Enzyme Inhibitors; Isoenzymes; Liver Circulation; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 2001 |
Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity.
Topics: Benzo(a)pyrene; Biotransformation; Caco-2 Cells; Caffeine; Cell Line, Tumor; Cell Survival; Coculture Techniques; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Humans; Intestinal Mucosa; Liver; Methylcholanthrene; Toxicity Tests | 2004 |