caffeine and 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine

caffeine has been researched along with 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	24 (36.92)	18.2507
2000's	35 (53.85)	29.6817
2010's	5 (7.69)	24.3611
2020's	1 (1.54)	2.80

Authors

Authors	Studies
Jacobson, KA; van Galen, PJ; Williams, M	1
Arslan, G; Fredholm, BB; Kull, B; Lorenzen, A; Nilsson, C; Owman, C; Schwabe, U	1
Ishiyama, H; Kobayashi, J; Nakata, H; Ohshita, K; Oyanagi, K	1
Abe, T; Ishiyama, H; Kobayashi, J; Nakata, H; Ohshita, K	1
Ishiyama, H; Kobayashi, J; Nakajima, H; Nakata, H	1
Bertarelli, DC; Borrmann, T; Florin, NC; Hinz, S; Li, W; Müller, CE; Scheiff, AB	1
de Lera Ruiz, M; Lim, YH; Zheng, J	1
Ahn, S; Cheong, JH; Jacobson, KA; Jeong, LS; Jin, SH; Kim, G; Kim, HJ; Kim, J; Lee, E; Lee, M; Noh, M; Yu, J	1
Gaba, S; Gupta, GD; Monga, V; Patel, R; Saini, A; Singh, G	1
Domenici, MR; Frank, C; Sagratella, S; Scotti de Carolis, A; Zeng, YC	1
Danhof, M; Gubbens-Stibbe, JM; Ijzerman, AP; Jacobson, KA; Mathôt, RA; Soudijn, W	1
Imaizumi, M; Miyazaki, S; Onodera, K	1
Jacobson, KA; Ji, XD; Kim, HO; Melman, N; Olah, ME; Stiles, GL	1
Howell, LL	1
Ahlberg, S; Brené, S; Fredholm, BB; Johansson, B; Lindefors, N; Persson, H; van der Ploeg, I	1
Poon, A; Sawynok, J	1
Chern, Y; Ching, YH; Lai, HL; Lee, EH; Lee, YC; Wang, HL	1
Kaneko, S; Mizuno, K; Okada, M	1
Fredholm, BB; Georgiev, V; Johansson, B; Lindström, K	1
Costentin, J; El Yacoubi, M; Heath, JK; Ledent, C; Parmentier, M; Pedrazzini, T; Schiffmann, SN; Vanderhaeghen, JJ; Vassart, G; Vaugeois, JM	1
Chang, YH; Chern, Y; Ching, YH; Conti, M; Lai, HL; Lee, YC	1
Frobenius, W; Geis, U; Hipp, J; Müller, CE; Pawłowski, M; Sandoval-Ramírez, J; Schobert, U; Suzuki, F	1
Cunha, RA; Gonçalves, ML; Ribeiro, JA	1
Khandwala, H; Loomis, CW; Zhang, Z	1
Assmann, H; Illes, P; Nörenberg, W; Richter, M; Wirkner, K	1
Kaneko, S; Kawata, Y; Kondo, T; Mizuno, K; Murakami, T; Okada, M; Wada, K	1
Fredholm, BB; Lindström, K	1
Ichikawa, S; Kitamura, S; Kuwana, Y; Nakamura, J; Shiozaki, S; Yamada, K	1
Baldo, BA; Koob, GF; Markou, A	1
Chrousos, GP; Crane, ML; Elenkov, IJ; Kino, T; Link, AA; McGuire, JL; Wilder, RL; Worth, JA	1
Liu, XJ; Reid, A; Sawynok, J	1
Borgeat, P; Bourgoin, SG; Harbour, D; Naccache, PH; Thibault, N	1
Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM	1
Aguirre-Bañuelos, P; Castañeda-Hernández, G; Granados-Soto, V; López-Muñoz, FJ; Pérez-Urizar, J	1
Capasso, A	1
Materi, LM; Rasmusson, DD; Semba, K	1
Dixon, AK; Freeman, TC; Lee, K; Preston, Z; Richardson, PJ; Widdowson, L	1
Adén, U; Fredholm, BB; Herlenius, E; Tang, LQ	1
Beilstein, MA; Chen, JF; Cuellar, B; Fink, JS; Grandy, DK; Hackett, E; Impagnatiello, F; Low, MJ; Moratalla, R; Ongini, E; Rubinstein, M; Schwarzschild, MA	1
Hamann, M; Richter, A	1
Nguyen, TT; White, PJ	1
Flood, AJ; Headrick, JP; Willems, L	1
Bibb, JA; Fienberg, AA; Fisone, G; Fredholm, BB; Greengard, P; Kim, Y; Lindskog, M; Nairn, AC; Pozzi, L; Svenningsson, P	1
Brenner, M; Danielczyk, W; Deckert, J; Durany, N; Jellinger, K; Paulus, W; Ransmayr, G; Riederer, P; Tatschner, T; Zöchling, R	1
Antoniou, K; Ferré, S; Fuxe, K; Goldberg, SR; Justinova, Z; Karcz-Kubicha, M; Müller, CE; Pezzola, A; Popoli, P; Quarta, D; Reggio, R; Solinas, M; Terasmaa, A	1
Blay, J; Butler, JJ; Hoskin, DW; Mader, JS; Watson, CL; Zhang, H	1
Goto, W; Hirao, M; Ikeda, T; Kobayashi, T; Oku, H; Sugiyama, T	1
Borycz, J; Ciruela, F; Ferré, S; Franco, R; Goldberg, SR; Hockemeyer, J; Lluis, C; Patkar, K; Quarta, D; Solinas, M; Woods, AS	1
Ferré, S; Goldberg, SR; Karcz-Kubicha, M; Müller, CE; Schindler, CW; Tella, SR; Thorndike, EB	1
Kogi, K; Konno, T; Nagai, A; Nakahata, N; Uchibori, T	1
Bayes-Genis, A; Casadó, V; Cinca, J; Ciruela, F; Franco, R; Hove-Madsen, L; Llach, A; Lluis, C; Prat-Vidal, C	1
Chen, HH; Pan, HZ	1
Bibb, JA; Galdi, S; Greene, RW; Hendrick, J; Sahin, B; Snyder, GL	1
Gu, R; Li, W; Shan, H; Wang, J; Wang, WH; Xu, Y; Yang, B; Zhang, Y	1
Cohen-Williams, ME; Grzelak, ME; Higgins, GA; Hodgson, RA; Pond, AJ; Varty, GB	1
Desfrere, L; Gressens, P; Olivier, P; Schwendimann, L; Verney, C	1
Edelman, GM; Jing, J; Jones, FS; Stevens, A; Stonehouse, AH	1
Batuca, JR; Conde, SV; Gonzalez, C; Monteiro, EC; Obeso, A	1
Koh, HC; Lee, CB	1
Baghdoyan, HA; Lydic, R; Van Dort, CJ	1
Chaimovitz, C; Douvdevani, A; Kachko, L; Nakav, S; Rogachev, B; Vorobiov, M; Zlotnik, M	1
Capasso, A; Gallo, C	1
Hiromura, M; Honda, S; Inoue, K; Kosako, K; Kuroki, H; Shiratani, T; Soeda, S; Toda, A; Uchiyama, H	1
Costa, G; Morelli, M; Simola, N	1
Gom, RC; Phillips, TJ; Teskey, GC; Wolff, MD	1

Reviews

3 review(s) available for caffeine and 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine

Article	Year
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship	1992
Adenosine A2A receptor as a drug discovery target. Journal of medicinal chemistry, 2014, May-08, Volume: 57, Issue:9 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Crystallography, X-Ray; Drug Discovery; Humans; Ligands; Protein Conformation; Receptor, Adenosine A2A; Signal Transduction	2014
Adenosine receptor antagonists: Recent advances and therapeutic perspective. European journal of medicinal chemistry, 2022, Jan-05, Volume: 227 Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Structure-Activity Relationship	2022

Other Studies

62 other study(ies) available for caffeine and 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine

Article	Year
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochemical pharmacology, 1999, Jan-01, Volume: 57, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Humans; Kinetics; PC12 Cells; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Triazoles; Tritium	1999
Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors. Bioorganic & medicinal chemistry, 2007, May-01, Volume: 15, Issue:9 Topics: Binding Sites; Caffeine; Carbolines; Cell Line; Humans; Ligands; Molecular Structure; Receptors, Purinergic P1; Structure-Activity Relationship	2007
Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Carbolines; Cell Line; Humans; Molecular Structure; Receptors, Purinergic P1; Structure-Activity Relationship	2008
Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors. Bioorganic & medicinal chemistry, 2009, Jul-01, Volume: 17, Issue:13 Topics: Binding, Competitive; Caffeine; Carbolines; Cell Line; Humans; Ligands; Protein Binding; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship	2009
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13 Topics: Adenosine A2 Receptor Antagonists; Animals; Drug Design; Humans; Kinetics; Ligands; Mice; Protein Binding; Radioligand Assay; Rats; Receptor, Adenosine A2B; Xanthines	2009
Polypharmacology of N Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals; Cell Line; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Male; Mice; Mice, Inbred C57BL; Polypharmacology; PPAR delta; PPAR gamma; Receptor, Adenosine A3	2017
Effects of adenosinergic drugs on hypoxia-induced electrophysiological changes in rat hippocampal slices. Life sciences, 1992, Volume: 51, Issue:13 Topics: Adenosine; Animals; Caffeine; Dizocilpine Maleate; Electrophysiology; Hippocampus; Hypoxia; In Vitro Techniques; Male; Membrane Potentials; Phenethylamines; Phenylisopropyladenosine; Potassium; Purinergic Antagonists; Rats; Rats, Inbred Strains; Synapses; Xanthines	1992
Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1 Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Caffeine; Drug Evaluation, Preclinical; Drug Interactions; Heart Rate; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats	1995
Effects of xanthine derivatives in a light/dark test in mice and the contribution of adenosine receptors. Methods and findings in experimental and clinical pharmacology, 1994, Volume: 16, Issue:9 Topics: Adenosine; Animals; Antihypertensive Agents; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Interactions; Light; Male; Mice; Phenethylamines; Purinergic P1 Receptor Antagonists; Structure-Activity Relationship; Theophylline; Xanthines	1994
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors. Journal of medicinal chemistry, 1994, Sep-30, Volume: 37, Issue:20 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Brain Chemistry; Caffeine; CHO Cells; Cricetinae; Gene Expression; Iodine Radioisotopes; Molecular Structure; Phenethylamines; Phenylisopropyladenosine; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Transfection; Xanthines	1994
Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Carbon Dioxide; Female; Hypercapnia; Hypoxia; Macaca mulatta; Male; Oxygen; Phenethylamines; Plethysmography; Pyrrolidinones; Receptors, Purinergic; Respiration; Respiratory Function Tests; Rolipram	1993
Effect of long term caffeine treatment on A1 and A2 adenosine receptor binding and on mRNA levels in rat brain. Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 347, Issue:4 Topics: Adenosine; Animals; Autoradiography; Base Sequence; Blotting, Northern; Brain; Caffeine; Corpus Striatum; Hippocampus; In Situ Hybridization; Male; Molecular Sequence Data; Organ Specificity; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; RNA, Messenger; Xanthines	1993
Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration. European journal of pharmacology, 1995, Nov-14, Volume: 286, Issue:2 Topics: Adenosine; Adenosine Kinase; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Caffeine; Deoxyadenosines; Enzyme Inhibitors; Formaldehyde; Male; Pentostatin; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1	1995
Circadian rhythm in the Ca(2+)-inhibitable adenylyl activity of the rat striatum. FEBS letters, 1996, May-06, Volume: 385, Issue:3 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Caffeine; Calcium; Circadian Rhythm; Colforsin; Corpus Striatum; Cyclic AMP; Guanosine Diphosphate; Isoenzymes; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley	1996
Adenosine A1 and A2 receptors modulate extracellular dopamine levels in rat striatum. Neuroscience letters, 1996, Jul-05, Volume: 212, Issue:1 Topics: Adenosine; Animals; Antihypertensive Agents; Caffeine; Camptothecin; Dopamine; Enzyme Inhibitors; Extracellular Space; Irinotecan; Male; Microdialysis; Neostriatum; Phenethylamines; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theobromine; Vasodilator Agents	1996
A1 and A2A adenosine receptors and A1 mRNA in mouse brain: effect of long-term caffeine treatment. Brain research, 1997, Jul-11, Volume: 762, Issue:1-2 Topics: Adenosine; Animals; Antihypertensive Agents; Autoradiography; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; In Situ Hybridization; Male; Mice; Mice, Inbred Strains; Phenethylamines; Radioligand Assay; Receptors, Purinergic P1; RNA, Messenger; Time Factors; Tritium; Xanthines	1997
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature, 1997, Aug-14, Volume: 388, Issue:6643 Topics: Adenosine; Aggression; Animals; Blood Pressure; Brain; Caffeine; Cloning, Molecular; Heart Rate; Humans; Hypertension; Male; Mice; Mice, Knockout; Molecular Sequence Data; Pain; Phenethylamines; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Restriction Mapping; Sequence Homology, Amino Acid	1997
Activation of phosphodiesterase IV during desensitization of the A2A adenosine receptor-mediated cyclic AMP response in rat pheochromocytoma (PC12) cells. Journal of neurochemistry, 1997, Volume: 69, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adrenal Gland Neoplasms; Animals; Blotting, Western; Caffeine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activation; Enzyme Inhibitors; Isoquinolines; Kinetics; PC12 Cells; Phenethylamines; Pheochromocytoma; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Recombinant Proteins; Sulfonamides	1997
Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26 Topics: Adenosine; Animals; Binding, Competitive; Brain; Caffeine; Molecular Structure; Phenethylamines; Protein Binding; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theobromine; Xanthines	1997
Adenosine A2A receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes. Neuroscience letters, 1997, Nov-28, Volume: 238, Issue:1-2 Topics: 2-Chloroadenosine; Adenosine; Animals; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Hippocampus; Male; omega-Agatoxin IVA; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Spider Venoms; Synaptosomes; Veratridine; Xanthines	1997
Inhibition of strychnine-allodynia is mediated by spinal adenosine A1- but not A2-receptors in the rat. Brain research, 1998, Oct-12, Volume: 808, Issue:1 Topics: Adenosine; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Spinal; Male; Pain; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Strychnine; Xanthines	1998
Adenosine A2A receptors inhibit the conductance of NMDA receptor channels in rat neostriatal neurons. Amino acids, 1998, Volume: 14, Issue:1-3 Topics: Adenosine; Adenylyl Cyclases; Animals; Caffeine; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Neostriatum; Neurons; Patch-Clamp Techniques; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Signal Transduction; Theophylline	1998
Differential effects of adenosine receptor subtypes on release and reuptake of hippocampal serotonin. The European journal of neuroscience, 1999, Volume: 11, Issue:1 Topics: Adenosine; Animals; Antihypertensive Agents; Biological Transport; Caffeine; Central Nervous System Stimulants; Fluoxetine; Hippocampus; Male; Microdialysis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quipazine; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Theobromine; Theophylline; Vasodilator Agents	1999
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors. European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3 Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines	1999
Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology, 1999, Volume: 147, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine; Animals; Antiparkinson Agents; Antipsychotic Agents; Caffeine; Catalepsy; Dopamine Agents; Hypokinesia; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenethylamines; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Reserpine; Theophylline	1999
Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Dec-15, Volume: 19, Issue:24 Topics: Adenosine; Animals; Brain; Caffeine; Cocaine; Differential Threshold; Dopamine Uptake Inhibitors; Drug Interactions; Electric Stimulation; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Reaction Time; Receptors, Purinergic P1; Reference Values; Reward; Substance Withdrawal Syndrome; Theobromine	1999
Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes. Journal of immunology (Baltimore, Md. : 1950), 2000, Jan-01, Volume: 164, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Caffeine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Immunologic; Female; Humans; Immunosuppressive Agents; Interleukin-10; Interleukin-12; Ligands; Lipopolysaccharides; Male; Monocytes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Signal Transduction	2000
Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists. European journal of pharmacology, 1999, Dec-15, Volume: 386, Issue:2-3 Topics: Acute Disease; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Drug Interactions; Edema; Enzyme Inhibitors; Histamine H1 Antagonists; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3	1999
Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases. Blood, 2000, Jan-15, Volume: 95, Issue:2 Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); ADP-Ribosylation Factor 1; Adult; Caffeine; Cell Membrane; Enzyme Activation; GTP Phosphohydrolases; Humans; In Vitro Techniques; Isoenzymes; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenethylamines; Phospholipase D; Protein Kinase C; Protein Kinase C-alpha; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; rhoA GTP-Binding Protein; Triazoles	2000
The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A(2A) adenosine receptor antagonists. Psychopharmacology, 2000, Volume: 148, Issue:2 Topics: Adenosine; Administration, Oral; Animals; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Administration Schedule; Injections, Intraperitoneal; Light; Male; Maze Learning; Mice; Mice, Knockout; Neuroprotective Agents; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Reaction Time; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines	2000
Activation of adenosine A1 receptors facilitates the analgesic effect of ketorolac and ketorolac-caffeine combinations in the rat. Proceedings of the Western Pharmacology Society, 1999, Volume: 42 Topics: Adenosine; Analgesics, Non-Narcotic; Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Drug Synergism; Female; Ketorolac; Pain Measurement; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar	1999
Adenosine receptors are involved in the control of acute naloxone-precipitated withdrawal: in vitro evidence. Life sciences, 2000, Volume: 66, Issue:10 Topics: Adenosine; Animals; Caffeine; Dipyridamole; Guinea Pigs; Ileum; In Vitro Techniques; Male; Naloxone; Narcotic Antagonists; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Substance Withdrawal Syndrome; Theobromine; Theophylline	2000
Inhibition of synaptically evoked cortical acetylcholine release by adenosine: an in vivo microdialysis study in the rat. Neuroscience, 2000, Volume: 97, Issue:2 Topics: Acetylcholine; Adenosine; Analysis of Variance; Animals; Caffeine; Cerebral Cortex; Chromatography, High Pressure Liquid; Dipyridamole; Male; Microdialysis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synapses; Xanthines	2000
Adenosine receptor expression and function in rat striatal cholinergic interneurons. British journal of pharmacology, 2000, Volume: 130, Issue:4 Topics: Acetylcholine; Adenosine; Adenosine Deaminase; Animals; Baclofen; Bicuculline; Caffeine; Cholinergic Fibers; Corpus Striatum; Dose-Response Relationship, Drug; GABA Antagonists; Gene Expression; Male; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Tritium; Xanthines	2000
Maternal caffeine intake has minor effects on adenosine receptor ontogeny in the rat brain. Pediatric research, 2000, Volume: 48, Issue:2 Topics: Adenosine; Animals; Animals, Newborn; Autoradiography; Brain; Caffeine; Female; Gene Expression Regulation, Developmental; In Situ Hybridization; Phenethylamines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Purinergic P1; Tritium; Xanthines	2000
The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America, 2001, Feb-13, Volume: 98, Issue:4 Topics: Adenosine; Amphetamines; Animals; Caffeine; Catalepsy; Corpus Striatum; Dopamine Antagonists; Enkephalins; Gene Expression; Haloperidol; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Purinergic P1; RNA, Messenger	2001
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. British journal of pharmacology, 2001, Volume: 134, Issue:2 Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines	2001
Chronic caffeine treatment causes changes in cardiac adenosine receptor function in rats. Pharmacology, 2002, Volume: 65, Issue:3 Topics: Adenosine; Animals; Blood Pressure; Caffeine; Central Nervous System Stimulants; Female; Heart Rate; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Stimulation, Chemical	2002
Coronary function and adenosine receptor-mediated responses in ischemic-reperfused mouse heart. Cardiovascular research, 2002, Volume: 55, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenosine Diphosphate; Animals; Caffeine; Coronary Circulation; Heart; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocardial Contraction; Myocardial Reperfusion Injury; Nitroprusside; Perfusion; Phenethylamines; Purinergic P1 Receptor Antagonists; Vasodilator Agents; Xanthines	2002
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature, 2002, Aug-15, Volume: 418, Issue:6899 Topics: Adenosine; Animals; Caffeine; Central Nervous System Stimulants; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neostriatum; Nerve Tissue Proteins; Neurons; Phenethylamines; Phosphoproteins; Phosphorylation; Phosphothreonine; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P1; Triazoles	2002
Up-regulation of striatal adenosine A(2A) receptors in schizophrenia. Neuroreport, 2003, Mar-03, Volume: 14, Issue:3 Topics: Adenosine; Aged; Aged, 80 and over; Antipsychotic Agents; Cadaver; Caffeine; Control Groups; Corpus Striatum; Female; Humans; Male; Middle Aged; Phenethylamines; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Schizophrenia; Up-Regulation	2003
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:7 Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Time Factors; Triazines; Triazoles; Tritium; Xanthines	2003
Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. Journal of cellular biochemistry, 2003, Aug-01, Volume: 89, Issue:5 Topics: Adenosine; Animals; Antibodies, Monoclonal; Caffeine; CD2 Antigens; CD28 Antigens; CD3 Complex; Cell Cycle; Colforsin; Cyclic AMP; Female; Flavins; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Phenethylamines; Receptors, Interleukin-2; Receptors, Purinergic P1; Signal Transduction; T-Lymphocytes; Tyrosine	2003
Effects of adenosine on optic nerve head circulation in rabbits. Experimental eye research, 2004, Volume: 79, Issue:5 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine A1 Receptor Antagonists; Adenylyl Cyclase Inhibitors; Animals; Caffeine; Capillaries; Dose-Response Relationship, Drug; Glyburide; Injections; Injections, Intravenous; Optic Disk; Phenethylamines; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rabbits; Regional Blood Flow; Stimulation, Chemical; Vasodilation; Vitreous Body; Xanthines	2004
Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation. Journal of neurochemistry, 2004, Volume: 91, Issue:4 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Synaptic Transmission; Theophylline	2004
Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists. British journal of pharmacology, 2005, Volume: 144, Issue:5 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Intraperitoneal; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines	2005
2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits. European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3 Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Alkynes; Animals; Antihypertensive Agents; Caffeine; Decanoic Acids; Glyburide; Hydroxy Acids; Hypotonic Solutions; Intraocular Pressure; Male; Ocular Hypertension; Phenethylamines; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits; Receptor, Adenosine A2A; Sodium Chloride; Time Factors; Xanthines	2005
Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release. Cardiovascular research, 2006, Nov-01, Volume: 72, Issue:2 Topics: Adenosine; Aged; Caffeine; Calcium; Calcium Channels, L-Type; Cyclic AMP-Dependent Protein Kinases; Female; Heart Atria; Humans; Immunohistochemistry; Isoquinolines; Male; Microscopy, Confocal; Middle Aged; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Receptors, Adenosine A2; Reverse Transcriptase Polymerase Chain Reaction; Ryanodine; Sarcoplasmic Reticulum; Sodium-Calcium Exchanger; Stimulation, Chemical; Sulfonamides	2006
Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats. Psychopharmacology, 2007, Volume: 191, Issue:1 Topics: Adenosine; Animals; Animals, Newborn; Anxiety; Avoidance Learning; Behavior, Animal; Body Temperature Regulation; Brain; Caffeine; Central Nervous System Stimulants; Female; Hot Temperature; Hyperalgesia; Male; Memory; Motor Activity; Pain Measurement; Pain Threshold; Phenethylamines; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Time Factors	2007
Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling. Brain research, 2007, Jan-19, Volume: 1129, Issue:1 Topics: Adenosine; Animals; Antihypertensive Agents; Caffeine; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Phenethylamines; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Presynaptic Terminals; Receptor, Adenosine A2A; Synaptic Membranes; Up-Regulation	2007
Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney. American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:1 Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenylyl Cyclases; Algorithms; Animals; Bucladesine; Caffeine; Dose-Response Relationship, Drug; Enzyme Activation; Female; Kidney; Male; Patch-Clamp Techniques; Phenethylamines; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Adenosine A2; Stimulation, Chemical; Xanthines	2007
The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors. Behavioural brain research, 2007, Dec-11, Volume: 185, Issue:1 Topics: Adenosine; Adenosine A2 Receptor Antagonists; Amphetamine; Animals; Antipsychotic Agents; Attention; Caffeine; Central Nervous System Stimulants; Choice Behavior; Dopamine; Dose-Response Relationship, Drug; Male; Motor Activity; Phenethylamines; Psychomotor Performance; Purines; Rats; Reaction Time; Reflex, Startle; Xanthines	2007
Transient inhibition of astrocytogenesis in developing mouse brain following postnatal caffeine exposure. Pediatric research, 2007, Volume: 62, Issue:5 Topics: Adenosine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Behavior, Animal; Body Weight; Brain; Caffeine; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Immunohistochemistry; Injections, Intraperitoneal; Mice; Microtubule-Associated Proteins; Models, Animal; Nerve Growth Factors; Organ Size; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Synaptophysin; Time Factors; Triazoles	2007
Caffeine stimulates cytochrome oxidase expression and activity in the striatum in a sexually dimorphic manner. Molecular pharmacology, 2008, Volume: 74, Issue:3 Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Base Pairing; Caffeine; Electron Transport Complex IV; Female; Gene Expression Regulation, Enzymologic; Male; Mice; Mice, Inbred C57BL; Neostriatum; PC12 Cells; Phenethylamines; Promoter Regions, Genetic; Rats; RNA, Messenger; RNA, Small Interfering; Sex Characteristics; Time Factors; Transcription, Genetic; Up-Regulation	2008
An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells. Journal of neurochemistry, 2008, Volume: 107, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; Acetamides; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Carotid Body; Catecholamines; Chemoreceptor Cells; Cyclic AMP; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Oxygen; Phenethylamines; Phosphodiesterase Inhibitors; Purines; Rats; Rats, Wistar; Receptor, Adenosine A2B; Receptors, Dopamine D2; Tritium; Vasodilator Agents	2008
Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats. Autonomic neuroscience : basic & clinical, 2009, Mar-12, Volume: 146, Issue:1-2 Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Aminoquinolines; Anesthesia, Inhalation; Animals; Blood Pressure; Bradycardia; Caffeine; Glipizide; Guanylate Cyclase; Heart Rate; Hypothalamus, Posterior; Imines; KATP Channels; Male; Microinjections; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A	2009
Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-21, Volume: 29, Issue:3 Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Arousal; Behavior, Animal; Caffeine; Chromatography, High Pressure Liquid; Electroencephalography; Electromyography; Male; Mice; Microdialysis; Phenethylamines; Phosphodiesterase Inhibitors; Prefrontal Cortex; Receptor, Adenosine A1; Receptors, Adenosine A2; Spectrum Analysis; Triazines; Triazoles; Xanthines	2009
Blocking adenosine A2A receptor reduces peritoneal fibrosis in two independent experimental models. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:8 Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cells, Cultured; Central Nervous System Stimulants; Chlorhexidine; Collagen; Disease Models, Animal; Fibroblasts; Fibrosis; Mice; Mice, Knockout; Peritoneal Cavity; Phenethylamines; Vasodilator Agents	2009
Functional interaction between purinergic system and opioid withdrawal: in vitro evidence. Current drug safety, 2009, Volume: 4, Issue:2 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Analgesics, Opioid; Animals; Caffeine; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Phenethylamines; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Quinidine; Receptor, Adenosine A1; Receptors, Adenosine A2; Receptors, Purinergic P2; Substance Withdrawal Syndrome; Theobromine; Theophylline	2009
Effect of adenosine system in the action of oseltamivir on behavior in mice. Neuroscience letters, 2015, Jul-10, Volume: 599 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Antiviral Agents; Behavior, Animal; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Neuraminidase; Oseltamivir; Phenethylamines; Pyrimidines; Receptors, Adenosine A2; Triazoles; Walking	2015
Activation of adenosine A₂A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic vocalizations in rats: possible relevance to reward and motivation. Psychopharmacology, 2016, Volume: 233, Issue:3 Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amphetamine; Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Interpersonal Relations; Male; Morphine; Motivation; Motor Activity; Narcotics; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Reward; Social Behavior; Vocalization, Animal	2016
Caffeine Exacerbates Postictal Hypoxia. Neuroscience, 2019, 12-01, Volume: 422 Topics: Adenosine; Animals; CA1 Region, Hippocampal; Caffeine; Dose-Response Relationship, Drug; Hypoxia; Kindling, Neurologic; Male; Oxygen; Phenethylamines; Pyrimidines; Rats; Receptors, Adenosine A2; Seizures; Triazoles	2019