caffeine and 1-methyl-3-isobutylxanthine

caffeine has been researched along with 1-methyl-3-isobutylxanthine in 121 studies

Research

Studies (121)

Timeframe	Studies, this research(%)	All Research%
pre-1990	56 (46.28)	18.7374
1990's	40 (33.06)	18.2507
2000's	15 (12.40)	29.6817
2010's	9 (7.44)	24.3611
2020's	1 (0.83)	2.80

Authors

Authors	Studies
Bridson, PK; Daly, JW; Hide, I	1
Browne, RG; Howard, HR; Koe, BK; Lebel, LA; Sarges, R; Seymour, PA	1
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Bruns, RF; Christ, WJ; Ibay, AC; Schneller, SW	1
Daly, JW; Padgett, WL; Shamim, MT	1
Daly, JW	1
Daly, JW; Gallo-Rodriguez, C; Jacobson, KA; Kiriasis, L; Manning, M; Müller, C; Neumeyer, JL; Pfleiderer, W; Shi, D	1
Borea, PA; Dalpiaz, A; Gilli, G; Gilli, P; Scatturin, A; Varani, K	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Conradi, R; Lee, PH; Shanmugasundaram, V	1
Ahn, S; Cheong, JH; Jacobson, KA; Jeong, LS; Jin, SH; Kim, G; Kim, HJ; Kim, J; Lee, E; Lee, M; Noh, M; Yu, J	1
Glass, WF; Moore, JB	1
Anderson, WH; Fitzpatrick, DF; Hwang, DP; Krzanowski, JJ; Polson, JB; Szentivanyi, A	1
Goz, B; Wharton, W	2
Mizutani, A; Sugimura, K	1
Garcia, L; Rogers, BJ	1
Lehnert, S	1
Edstrom, JP; Kirkpatrick, JR; Kostopoulos, GK; Phillis, JW	1
Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S	1
Isenberg, G	1
De La Torre, C; Grenet, J; Sans, J	1
Suzuki, R; Yoshino, H	1
Bishopric, NH; Sato, B; Webster, KA	1
Mante, S; Minneman, KP	1
Ajiro, K; Nishikawa, Y; Shibata, K	1
Farb, DH; Friedman, L; Gibbs, TT; Roca, DJ; Rozenberg, I; Schiller, GD	1
Bolton, TB; Hering, S; Hughes, AD	1
Kehoe, J	2
Gellert, M; Menetski, JP	1
Frings, S; Lindemann, B	1
Belan, PV; Kostyuk, PG; Tepikin, AV	1
Hamilton, AM; Hoh, JF; Rossmanith, GH	1
Baidan, LV; Shuba, MF; Zholos, AV	1
Kafengauz, BIu; Poskonova, MA	1
Morse, DE; Ness, JC	1
Coffin, VL; Spealman, RD	2
Barraco, RA; DeLong, RE; Phillis, JW; Washington, DO	1
Freerksen, DL; Hartzell, CR; Johnson, GV; Schroedl, NA	1
Gilboe, DP	1
DeLander, GE; Hopkins, CJ	1
Dar, MS; Wooles, WR	1
Holtzman, SG	1
Copelas, L; Feldman, MD; Grossman, W; Gwathmey, JK; Morgan, JP; Phillips, P; Schoen, FJ; Warren, SE	1
Aitken, RJ; Irvine, S; Mattei, A	1
Close, G; Dar, MS; Jones, M; Mustafa, SJ; Wooles, WR	1
Chang, G; Dillehay, LE; Williams, JR	1
Brown, DL; Harris, DM	1
Dryden, WF; Gordon, T; Lazarenko, G; Singh, YN	1
Barber, B; Fluck, R; Sguigna, C	1
Choi, OH; Daly, JW; Padgett, WL; Shamim, MT	1
Dacke, CG; Shaw, AJ	1
Cooksley, WG; Halliday, JW; McIvor, C; Murphy, TL; Powell, LW; Yap, A	1
Mersmann, HJ	1
Diaz, C; Gill, JM; Schiffman, SS	1
Fredholm, BB	1
Schimmel, RJ	1
Ashcroft, SJ; Sugden, MC; Williams, IH	1
Hollins, C; Lloyd, H; Stone, TW	1
Collier, HO; Cuthbert, NJ; Francis, DL	1
Court, JM; Dunlop, M; Larkins, RG	1
Kramer, GL; Wells, JN	1
Liao, HH; Thorner, J	1
Anuras, S	1
Azuma, K; Azuma, M	1
Boadle-Biber, MC	1
Blankenship, LC; Craven, SE	1
Kann, ML; Serres, C	1
Daniel, JW; Oleinick, NL	1
Annau, Z; Bruns, RF; Daly, JW; Katims, JJ; Snyder, SH	1
Kopf, GS; Lewis, CA; Vacquier, VD	1
Epstein, PM; Hachisu, R	1
Plagemann, PG; Wohlhueter, RM	1
Sklar, P; Snyder, SH	1
Altman, HJ; Barraco, RA; Coffin, VL; Phillis, JW; Taylor, JA	1
Nathanson, JA	1
Jiang, CS; Kilfeather, SA; Pearson, RM; Turner, P	1
Kostyuk, P; Usachev, Y; Verkhratsky, A	1
Ogihara, M	1
Wyskovsky, W	1
Malcolm, AR; Mills, LJ; Nelson, SM	1
Berthon, B; Claret, M; Combettes, L	1
Bolton, TB; Prestwich, SA	1
Karhapää, L; Törnquist, K	1
Usachev, Y; Verkhratsky, A	1
Fredholm, BB; Johansson, B; Svenningsson, P	1
Daly, JW; Jacobson, KA; Nikodijević, O	1
Knöpfel, T; Staub, C; Vranesic, I	1
Howell, LL	1
Palade, P; Zahradník, I	1
Kao, LS; Lin, YJ; Liu, PS	1
Chen, B; Choi, GH; Gao, S; Nuss, DL	1
D'Souza, T; Dryer, SE; Reiser, MA	1
De Sarro, A; De Sarro, G; Grasso, S; Nava, F; Zappala, M	1
Anderson, PJ; Fujikura, Y; Suzuki, R	1
Elliott, AC; Lee, SI; Seo, JT; Steward, MC; Sugiya, H	1
Cheuk, G; Kamagata-Kiyoura, Y; Nakamoto, T; Ohta, M; Saltzman, MJ; Yazdani, M	1
Daly, JW; Shi, D	1
Furuya, K; Kato, K; Ozaki, T; Tsutsui, I; Yamagishi, S	1
Ito, Y; Masaki, I; Sueishi, K; Takano, M; Tanaka, K; Teramoto, N; Yonemitsu, Y; Yunoki, T	1
Christophersen, P; Jensen, BS; Olesen, SP; Schrøder, RL; Strøbaek, D	1
Becq, F; Bulteau, L; Dérand, R; Dormer, RL; Folli, C; Galietta, LJ; Joffre, M; Jougla, C; McNeilly, CM; Métayé, T; Mettey, Y; Morris, MR; Pereira, MM; Vierfond, JM; Zegarra-Moran, O	1
Steinbusch, HW	1
Ho, HC; Suarez, SS	1
Anderson, KE; Daniele, N; Foukas, LC; Jensen, J; Ktori, C; Shepherd, PR	1
O'Farrell, M; Ziogas, J	1
Marquez, B; Suarez, SS	1
Bai, Y; Sanderson, MJ	1
Anderson, CM; Thwaites, DT	1
Bulaeva, SV; Chuchkanov, FA; Maimistova, AA; Muravyov, AV; Yakusevich, VV; Zaitsev, LG	1
Batuca, JR; Conde, SV; Gonzalez, C; Monteiro, EC; Obeso, A	1
Chatterjee, M; Ghosh, S; Nandi, P; Sen, PC	1
Britton, F; Dixon, R; Hwang, S; Sanders, K; Ward, S	1
Hayashi, K; Miwa, S; Nishida, H; Ohnari, I; Shirai, T; Sugimoto, N; Takeuchi, A; Tsuchiya, H; Yachie, A	1
Chen, L; Huang, F; Li, W; Li, X; Liu, Z; Luo, Z; Wu, H; Xu, Y; Young, C; Zhou, S	1
Aiyar, P; Akkali, R; Baskar, R; Jaiswal, P; Singh, SP	1
Huang, L; Malach, E; Naim, M; Peri, I; Seger, R; Shaul, ME; Spielman, AI	1
Bao, BY; Hu, TC; Lee, HZ; Lee, MH; Tien, N; Wu, YS; You, BJ	1
Alessandri, MP; Larrondo, LF; Olivares-Yañez, C; Salas, L	1

Reviews

6 review(s) available for caffeine and 1-methyl-3-isobutylxanthine

Article	Year
Adenosine receptors: targets for future drugs. Journal of medicinal chemistry, 1982, Volume: 25, Issue:3 Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Ligands; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Xanthines	1982
Gastrointestinal and metabolic effects of methylxanthines. Progress in clinical and biological research, 1984, Volume: 158 Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Caffeine; Calcium; Carbohydrate Metabolism; Digestive System; Energy Metabolism; Esophagus; Gastric Acid; Humans; Lipid Metabolism; Lipolysis; Liver; Pancreas; Saliva; Theophylline; Thyroid Gland; Xanthines	1984
Carbohydrate metabolism and the glucoreceptor mechanism. Hormone and metabolic research. Supplement series, 1980, Volume: Suppl 10 Topics: 1-Methyl-3-isobutylxanthine; Acetylglucosamine; Animals; Caffeine; Calcium; Cyclic AMP; Glucosamine; Glucose; Humans; Insulin; Islets of Langerhans; Mitochondria; Receptors, Cell Surface	1980
Phosphodiesterase inhibitors as tools in cyclic nucleotide research: a precautionary comment. Molecular and cellular endocrinology, 1981, Volume: 23, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Cyclic AMP; Cyclic GMP; Isoenzymes; Phosphodiesterase Inhibitors; Theophylline; Xanthines	1981
Adenosine receptor interactions and anxiolytics. Neuropharmacology, 1983, Volume: 22, Issue:12B Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Diazepam; Humans; Motor Activity; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Purinergic	1983
Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts. Advances in cyclic nucleotide and protein phosphorylation research, 1984, Volume: 16 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Caffeine; Cells, Cultured; Humans; Kinetics; Leukemia; Lymphocyte Activation; Lymphocytes; Reference Values; Theophylline	1984

Other Studies

115 other study(ies) available for caffeine and 1-methyl-3-isobutylxanthine

Article	Year
Imidazodiazepinediones: a new class of adenosine receptor antagonists. Journal of medicinal chemistry, 1990, Volume: 33, Issue:10 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Azepines; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Imidazoles; In Vitro Techniques; Molecular Conformation; Phenylisopropyladenosine; Rats; Receptors, Purinergic; Structure-Activity Relationship	1990
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants. Journal of medicinal chemistry, 1990, Volume: 33, Issue:8 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Cats; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Corpus Striatum; Male; Molecular Structure; Motor Activity; Purinergic Antagonists; Quinoxalines; Rats; Receptors, Purinergic; Sleep; Structure-Activity Relationship; Triazoles	1990
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists. Journal of medicinal chemistry, 1989, Volume: 32, Issue:10 Topics: Animals; Brain; Cell Membrane; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Rats; Receptors, Purinergic; Structure-Activity Relationship; Xanthines	1989
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. Journal of medicinal chemistry, 1986, Volume: 29, Issue:7 Topics: Animals; Caffeine; Cell Membrane; Cerebral Cortex; Indicators and Reagents; Mass Spectrometry; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Xanthines	1986
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors. Journal of medicinal chemistry, 1993, Sep-03, Volume: 36, Issue:18 Topics: Acylation; Alkylation; Animals; Brain; Caffeine; Cell Membrane; Cyclization; Molecular Structure; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Trifluoroacetic Acid; Xanthines	1993
Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors. Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6 Topics: Estradiol; Female; Humans; In Vitro Techniques; Male; Metribolone; Pregnenediones; Prostate; Receptors, Androgen; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Thermodynamics; Uterus	2005
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption	2010
Polypharmacology of N Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals; Cell Line; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Male; Mice; Mice, Inbred C57BL; Polypharmacology; PPAR delta; PPAR gamma; Receptor, Adenosine A3	2017
Inhibition of human lung cyclic GMP and cyclic AMP phosphodiesterases by certain nucleosides, nucleotides, and pharmacological phosphodiesterase inhibitors. Biochemical pharmacology, 1979, Apr-01, Volume: 28, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aminophylline; Caffeine; Etazolate; Humans; In Vitro Techniques; Kinetics; Lung; Nucleosides; Nucleotides, Cyclic	1979
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle. Biochemical pharmacology, 1979, Apr-15, Volume: 28, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Animals; Caffeine; Dogs; Etazolate; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Theophylline; Trachea; Triazoles	1979
Induction of alkaline phosphatase activity in HeLa cells. Inhibition by xanthine derivatives and thermostability studies. Biochemical pharmacology, 1979, Mar-15, Volume: 28, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Caffeine; Enzyme Induction; HeLa Cells; Hot Temperature; Humans; Protein Denaturation; Theophylline; Time Factors; Xanthines	1979
The inhibitory effect of xanthine derivatives on alkaline phosphatase in the rat brain. Histochemistry, 1979, Jun-18, Volume: 61, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Aminophylline; Animals; Caffeine; Cerebral Cortex; Female; Histocytochemistry; Male; Rats; Synaptosomes; Theophylline; Xanthines	1979
Effect of cAMP on acrosome reaction and fertilization. Biology of reproduction, 1979, Volume: 21, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Acrosome; Animals; Bucladesine; Caffeine; Cricetinae; Cyclic AMP; Female; Fertilization; Guinea Pigs; Imidazoles; Male; Ovum; Phosphodiesterase Inhibitors; Sperm Motility; Spermatozoa; Theophylline	1979
The inhibition by xanthine phosphodiesterase inhibitors of the induction of alkaline phosphatase activity in HeLa cells: relationship of enzyme activity to cyclic AMP concentrations. Journal of cellular physiology, 1979, Volume: 100, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Induction; HeLa Cells; Humans; Hydrocortisone; Idoxuridine; Theophylline; Xanthines	1979
Radioprotection of mouse intestine by inhibitors of cyclic AMP phosphodiesterase. International journal of radiation oncology, biology, physics, 1979, Volume: 5, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cell Survival; Jejunum; Male; Mice; Radiation-Protective Agents; Reserpine; Theophylline	1979
Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex. Canadian journal of physiology and pharmacology, 1979, Volume: 57, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Animals; Brain; Caffeine; Cerebral Cortex; Male; Neural Inhibition; Neurons; Rats; Synapses; Synaptic Transmission; Theophylline	1979
Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study. European journal of pharmacology, 1992, Nov-03, Volume: 222, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Caffeine; Electroencephalography; Male; Parasympatholytics; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Theophylline; Xanthines	1992
Caffeine-induced release and reuptake of Ca2+ by Ca2+ stores in myocytes from guinea-pig urinary bladder. The Journal of physiology, 1992, Volume: 458 Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Caffeine; Calcium; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscle, Smooth; Spectrometry, Fluorescence; Urinary Bladder	1992
Effect of caffeine and isobutyl-methyl-xanthine on production of binucleate cells and on post-replicative repair. Cytobios, 1992, Volume: 69, Issue:276 Topics: 1-Methyl-3-isobutylxanthine; Allium; Caffeine; Cell Cycle; Cells, Cultured; DNA Repair; G2 Phase; Prophase	1992
Effect of phosphodiesterase inhibitors on bovine ciliary muscle and outflow facility. Journal of ocular pharmacology, 1992,Summer, Volume: 8, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Aqueous Humor; Caffeine; Cattle; Ciliary Body; Muscle Contraction; Perfusion; Phosphodiesterase Inhibitors; Theophylline	1992
Beta-adrenergic regulation of a myocardial actin gene via a cyclic AMP-independent pathway. The Journal of biological chemistry, 1992, Oct-15, Volume: 267, Issue:29 Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Actins; Animals; Animals, Newborn; Blotting, Northern; Bucladesine; Caffeine; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Enkephalins; Gene Expression Regulation; Heart; Heart Ventricles; Isoproterenol; Kinetics; Myocardium; Nifedipine; Potassium Chloride; Propranolol; Protein Precursors; Rats; Receptors, Adrenergic, beta; RNA; RNA, Messenger; Ryanodine	1992
Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain. European journal of pharmacology, 1990, Jan-10, Volume: 175, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Caffeine; Cerebral Cortex; Colforsin; Cyclic AMP; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline	1990
Subtype-specific cyclic AMP-dependent histone H1 phosphorylation at the differentiation of mouse neuroblastoma cells. The Journal of biological chemistry, 1990, Apr-15, Volume: 265, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Histones; Mice; Neuroblastoma; Peptide Mapping; Phosphates; Phosphopeptides; Phosphorylation; Theophylline; Tumor Cells, Cultured; Tyrosine	1990
gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines. Molecular pharmacology, 1990, Volume: 37, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Allosteric Regulation; Animals; Barbital; Barbiturates; Brain; Caffeine; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Pentobarbital; Receptors, GABA-A; Tetrodotoxin; Theophylline; Veratridine	1990
The action of caffeine on inward barium current through voltage-dependent calcium channels in single rabbit ear artery cells. Pflugers Archiv : European journal of physiology, 1990, Volume: 416, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Barium; Caffeine; Calcium Channels; Cell Membrane; Ear; Electric Conductivity; Female; Ion Channels; Male; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rabbits; Rolipram; Xanthines	1990
Cyclic AMP-induced slow inward current in depolarized neurons of Aplysia californica. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:10 Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Caffeine; Calcium; Cyclic AMP; Electric Conductivity; Ganglia; Ion Channels; Magnesium; Mannitol; Meglumine; Membrane Potentials; Neurons; Phosphodiesterase Inhibitors; Potassium; Protein Kinase Inhibitors; Sodium; Tetraethylammonium; Tetraethylammonium Compounds	1990
Cyclic AMP-induced slow inward current: its synaptic manifestation in Aplysia neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:10 Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Caffeine; Calcium; Cyclic AMP; Electric Conductivity; Hydrogen-Ion Concentration; Neurons; Phosphodiesterase Inhibitors; Potassium Channels; Synapses; Tetraethylammonium; Tetraethylammonium Compounds	1990
V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:23 Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; B-Lymphocytes; Blotting, Northern; Caffeine; Cell Line; Cyclic AMP; Immunoglobulin Joining Region; Immunoglobulin Variable Region; Kinetics; Mice; Plasmids; Recombination, Genetic; RNA, Messenger; T-Lymphocytes; Theophylline; Transfection	1990
Current recording from sensory cilia of olfactory receptor cells in situ. I. The neuronal response to cyclic nucleotides. The Journal of general physiology, 1991, Volume: 97, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Caffeine; Cilia; Colforsin; Cyclic AMP; Cyclic GMP; Electrophysiology; In Vitro Techniques; Nasal Mucosa; Phosphodiesterase Inhibitors; Rana esculenta; Rana ridibunda; Sensory Receptor Cells; Smell	1991
Free calcium transients and oscillations in nerve cells. Experimental brain research, 1991, Volume: 83, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Fura-2; Guanylyl Imidodiphosphate; Helix, Snails; Membrane Potentials; Microelectrodes; Neurons; Theophylline; Thymol; Xanthines	1991
Effects of dibutyryl cyclic AMP, ouabain, and xanthine derivatives on crossbridge kinetics in rat cardiac muscle. Circulation research, 1991, Volume: 68, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Caffeine; Cardiotonic Agents; Kinetics; Myocardial Contraction; Ouabain; Papillary Muscles; Rats; Rats, Inbred Strains; Xanthines	1991
The inhibitory action of caffeine on calcium currents in isolated intestinal smooth muscle cells. Pflugers Archiv : European journal of physiology, 1991, Volume: 419, Issue:3-4 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Separation; Electrophysiology; Intestinal Mucosa; Intestines; Muscle, Smooth; Potassium Channels; Time Factors	1991
[Action of cyclic nucleotide phosphodiesterase inhibitors on the acetylcholine potential]. Biulleten' eksperimental'noi biologii i meditsiny, 1985, Volume: 99, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcholine; Animals; Bucladesine; Caffeine; Diaphragm; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Membrane Potentials; Mice; Muscles; Theophylline	1985
Regulation of galactokinase gene expression in Tetrahymena thermophila. I. Intracellular catecholamine control of galactokinase expression. The Journal of biological chemistry, 1985, Aug-25, Volume: 260, Issue:18 Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Agonists; Animals; Caffeine; Catecholamines; Cyclic AMP; Galactokinase; Genes; Glucagon; Glucose; Histamine; Insulin; Kinetics; Tetrahymena; Theophylline	1985
Modulation of the behavioral effects of chlordiazepoxide by methylxanthines and analogs of adenosine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Chlordiazepoxide; Conditioning, Psychological; Male; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Saimiri; Theobromine; Theophylline; Xanthines	1985
Behavioral characteristics of centrally administered adenosine analogs. Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Caffeine; Dilazep; Dipyridamole; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Motor Activity	1986
Increased aerobic glucose oxidation by cAMP in cultured regenerated skeletal myotubes. The American journal of physiology, 1986, Volume: 250, Issue:5 Pt 1 Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Aerobiosis; Animals; Caffeine; Cells, Cultured; Cholera Toxin; Creatine Kinase; Cyclic AMP; Glucose; Isocitrate Dehydrogenase; Isoenzymes; L-Lactate Dehydrogenase; Malate Dehydrogenase; Male; Muscles; Oxidation-Reduction; Rats; Rats, Inbred Strains	1986
The mechanism of caffeine-enhanced glucose stimulation of liver glycogen synthase phosphatase activity. Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Drug Interactions; Glucose; Glucose-6-Phosphate; Glucosephosphates; Liver; Male; Phosphoprotein Phosphatases; Rats; Structure-Activity Relationship; Theobromine; Theophylline; Time Factors; Xanthine; Xanthines	1986
Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Analgesia; Animals; Caffeine; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Nociceptors; Spinal Cord; Theophylline; Xanthines	1986
Effect of chronically administered methylxanthines on ethanol-induced motor incoordination in mice. Life sciences, 1986, Oct-20, Volume: 39, Issue:16 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Brain; Caffeine; Drug Synergism; Ethanol; Kinetics; Male; Mice; Motor Activity; Receptors, Purinergic; Theophylline; Xanthines	1986
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline	1986
Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure. Circulation, 1987, Volume: 75, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Calcium; Cardiotonic Agents; Colforsin; Cyclic AMP; Heart Failure; Humans; Isoproterenol; Milrinone; Myocardial Contraction; Myocardium; Pyridones; Stimulation, Chemical; Strophanthidin	1987
Paradoxical stimulation of human sperm motility by 2-deoxyadenosine. Journal of reproduction and fertility, 1986, Volume: 78, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Caffeine; Calcimycin; Colforsin; Cyclic AMP; Deoxyadenosines; Freezing; Humans; Male; Sperm Motility; Spermatozoa; Stimulation, Chemical	1986
Behavioral interactions of ethanol and methylxanthines. Psychopharmacology, 1987, Volume: 91, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Posture; Psychomotor Performance; Reflex; Theophylline; Xanthines	1987
Effects of methylxanthines on cell-cycle redistribution and sensitization to killing by low-dose-rate radiation. NCI monographs : a publication of the National Cancer Institute, 1988, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Cell Cycle; Cell Survival; Humans; Radiation Dosage; Radiation Tolerance; Theophylline; Tumor Cells, Cultured	1988
Effects of caffeine and 3-isobutyl 1-methyl xanthine on caprine milk secretion. Journal of dairy science, 1988, Volume: 71, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Fats; Female; Goats; Infusions, Intravenous; Injections, Intramuscular; Lactation; Milk; Milk Proteins; Pregnancy; Theophylline	1988
Pharmacological elevation of cyclic AMP and transmitter release at the mouse neuromuscular junction. Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cholera Toxin; Colforsin; Cyclic AMP; Evoked Potentials; Fluorides; In Vitro Techniques; Mice; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Theophylline	1988
Calcium dependence of rhythmic contractions of the Oryzias latipes blastoderm. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1988, Volume: 89, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastoderm; Bucladesine; Caffeine; Calcium; Calcium Channel Blockers; Cyprinodontiformes; Oryzias; Papaverine; Theophylline	1988
Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors. Life sciences, 1988, Volume: 43, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Caffeine; Calcium; In Vitro Techniques; Male; Mice; Motor Activity; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship; Theophylline	1988
Cyclic nucleotides and the rapid inhibitions of bone 45Ca uptake in response to bovine parathyroid hormone and 16,16-dimethyl prostaglandin E2 in chicks. Calcified tissue international, 1989, Volume: 44, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 16,16-Dimethylprostaglandin E2; Animals; Bone and Bones; Bucladesine; Caffeine; Calcium; Calcium Radioisotopes; Chickens; Cyclic AMP; Male; Nucleotides, Cyclic; Parathyroid Hormone; Peptide Fragments; Prostaglandins E, Synthetic; Theophylline	1989
Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline. European journal of pharmacology, 1989, Oct-24, Volume: 170, Issue:1-2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intravenous; Male; Psychomotor Performance; Reinforcement Schedule; Saimiri; Stimulation, Chemical; Theophylline	1989
The effect of smoking on caffeine elimination: implications for its use as a semiquantitative test of liver function. Clinical and experimental pharmacology & physiology, 1988, Volume: 15, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adult; Antipyrine; Caffeine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Liver Function Tests; Male; Middle Aged; Smoking; Substance Withdrawal Syndrome	1988
Inhibition of porcine adipose tissue lipogenesis by beta-adrenergic agonists. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1989, Volume: 94, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adipose Tissue; Adrenergic beta-Agonists; Animals; Caffeine; Drug Interactions; Epinephrine; Isoproterenol; Lipids; Male; Propranolol; Swine; Theophylline	1989
Methyl xanthines enhance taste: evidence for modulation of taste by adenosine receptor. Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adult; Animals; Caffeine; Female; Humans; In Vitro Techniques; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Taste; Theobromine; Theophylline; Xanthines	1985
Interactions between catecholamines, methyl xanthines and adenosine in regulation of cyclic AMP accumulation in hamster adipocytes. Biochimica et biophysica acta, 1980, Apr-17, Volume: 629, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase; Adipose Tissue; Animals; Caffeine; Catecholamines; Cricetinae; Cyclic AMP; Epinephrine; Isoproterenol; Mesocricetus; Norepinephrine; Phentolamine; Theophylline	1980
Methylxanthines modulate adenosine release from slices of cerebral cortex. Brain research, 1981, Mar-02, Volume: 207, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenosine Triphosphatases; Aminophylline; Animals; Caffeine; Cerebral Cortex; Cyclic AMP; gamma-Aminobutyric Acid; Male; Mice; Ouabain; Theophylline; Xanthines	1981
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines. Federation proceedings, 1981, Volume: 40, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Humans; Hypoxanthines; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Pyrimidines; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Triazoles; Xanthines	1981
Methylxanthine effects on cyclic adenosine 3':5' monophosphate phosphodiesterase activity in preparations of neonatal rat cerebellum: modification by trifluoperazine. Biochemical and biophysical research communications, 1981, Feb-12, Volume: 98, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Animals, Newborn; Caffeine; Cerebellum; Drug Interactions; In Vitro Techniques; Kinetics; Rats; Theophylline; Trifluoperazine	1981
Adenosine 3',5'-phosphate phosphodiesterase and pheromone response in the yeast Saccharomyces cerevisiae. Journal of bacteriology, 1981, Volume: 148, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Aminophylline; Caffeine; Cyclic AMP; Interphase; Mating Factor; Peptides; Saccharomyces cerevisiae; Theophylline; Xanthines	1981
cAMP and calcium in generation of slow waves in cat colon. The American journal of physiology, 1982, Volume: 242, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Bucladesine; Caffeine; Calcium; Cats; Colon; Cyclic AMP; Dibutyryl Cyclic GMP; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth; Theophylline; Time Factors	1982
The action of phosphodiesterase inhibitors on the hypersensitivity of frog photoreceptor. Vision research, 1982, Volume: 22, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; In Vitro Techniques; Light; Papaverine; Phosphodiesterase Inhibitors; Photoreceptor Cells; Rana catesbeiana; Theophylline	1982
Blockade by haloperidol of the increase in tryptophan hydroxylase activity induced by incubation of slices of brain stem with dibutyryl cyclic AMP. Biochemical pharmacology, 1982, Jun-15, Volume: 31, Issue:12 Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Stem; Bucladesine; Caffeine; Calcium; Haloperidol; Male; Rats; Theophylline; Tryptophan Hydroxylase	1982
Effect of purine derivatives, papaverine hydrochloride, and imidazole on enterotoxin formation by Clostridium perfringens type A. Canadian journal of microbiology, 1982, Volume: 28, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Clostridium perfringens; Enterotoxins; Imidazoles; Mercaptopurine; Papaverine; Spores, Bacterial; Theophylline	1982
Development and initiation of sperm motility in the hamster epididymis. Reproduction, nutrition, developpement, 1980, Volume: 20, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cricetinae; Cyclic AMP; Epididymis; Kinetics; Male; Semen; Sperm Motility; Spermatozoa; Theophylline	1980
Cyclic nucleotide responses and radiation-induced mitotic delay in Physarum polycephalum. Radiation research, 1984, Volume: 97, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Caffeine; Cobalt Radioisotopes; Cyclic AMP; Cyclic GMP; Gamma Rays; Mitosis; Phosphodiesterase Inhibitors; Physarum; Theophylline; Time Factors	1984
Characterization of basal and methylxanthine-stimulated Ca2+ transport in abalone spermatozoa. The Journal of biological chemistry, 1984, May-10, Volume: 259, Issue:9 Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Biological Transport, Active; Caffeine; Calcium; Hydrogen-Ion Concentration; Kinetics; Male; Mollusca; Potassium Cyanide; Spermatozoa; Theobromine; Theophylline; Xanthines	1984
Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6-phenylisopropyladenosine. Biochemical pharmacology, 1984, Jun-01, Volume: 33, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Biological Transport, Active; Caffeine; Cell Line; Hypoxanthine; Hypoxanthines; Liver Neoplasms, Experimental; Papaverine; Phenylisopropyladenosine; Rats; Theophylline; Uridine; Xanthines	1984
Behavioral and molecular actions of caffeine: focus on adenosine. Journal of psychiatric research, 1984, Volume: 18, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anxiety Disorders; Behavior; Caffeine; Child; Cyclic AMP; Diagnosis, Differential; Humans; Male; Phenylisopropyladenosine; Psychomotor Performance; Rats; Receptors, Cell Surface; Receptors, Purinergic; Seizures; Sleep Initiation and Maintenance Disorders; Stimulation, Chemical; Tea; Xanthines	1984
Behavioral interaction of adenosine and methylxanthines on central purinergic systems. Neuroscience letters, 1984, Jun-15, Volume: 47, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Caffeine; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity; Papaverine; Theophylline	1984
Caffeine and related methylxanthines: possible naturally occurring pesticides. Science (New York, N.Y.), 1984, Oct-12, Volume: 226, Issue:4671 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Chlorphenamidine; Cyclic AMP; Feeding Behavior; Insecta; Insecticides; Larva; Lepidoptera; Moths; Papaverine; Pesticide Synergists; Theophylline; Xanthines	1984
The stimulatory effects of caffeine, theophylline, lysine-theophylline and 3-isobutyl-1-methylxanthine on human sperm motility. British journal of clinical pharmacology, 1984, Volume: 18, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Caffeine; Humans; In Vitro Techniques; Male; Sperm Motility; Theophylline; Xanthines	1984
3-Isobutyl-1-methylxanthine (IBMX) affects potassium permeability in rat sensory neurones via pathways that are sensitive and insensitive to [Ca2+]in. Pflugers Archiv : European journal of physiology, 1995, Volume: 430, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channels; Fura-2; Ganglia, Spinal; In Vitro Techniques; Neural Pathways; Neurons, Afferent; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium; Rats; Ryanodine	1995
Nifedipine and nicardipine potentiate glucagon-stimulated glycogenolysis in primary cultures of rat hepatocytes. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:9 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glycogen; Liver; Male; Nicardipine; Nifedipine; Papaverine; Rats; Rats, Wistar	1993
Caffeine-induced calcium oscillations in heavy-sarcoplasmic-reticulum vesicles from rabbit skeletal muscle. European journal of biochemistry, 1994, Apr-01, Volume: 221, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channels; Hydrogen-Ion Concentration; Magnesium Chloride; Muscle Proteins; Muscles; Neomycin; Osmolar Concentration; Osmotic Pressure; Rabbits; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Temperature; Theophylline	1994
Effects of selected anti-tumor-promoting chemicals on metabolic cooperation between Chinese hamster V79 cells. Toxicology and applied pharmacology, 1994, Volume: 126, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Acetates; Acetic Acid; Acetophenones; Animals; Anticarcinogenic Agents; Arachidonic Acid; Caffeine; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Gap Junctions; Lipoxygenase Inhibitors; Mutation; Phosphodiesterase Inhibitors; Phospholipases A; Protease Inhibitors; Pyrazoles; Tosylphenylalanyl Chloromethyl Ketone	1994
Caffeine inhibits cytosolic calcium oscillations induced by noradrenaline and vasopressin in rat hepatocytes. The Biochemical journal, 1994, Aug-01, Volume: 301 ( Pt 3) Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Caffeine; Calcium; Colforsin; Cytosol; Dose-Response Relationship, Drug; Female; Inositol 1,4,5-Trisphosphate; Liver; Norepinephrine; Rats; Rats, Wistar; Vasopressins	1994
Inhibition of muscarinic receptor-induced inositol phospholipid hydrolysis by caffeine, beta-adrenoceptors and protein kinase C in intestinal smooth muscle. British journal of pharmacology, 1995, Volume: 114, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Caffeine; Calcium Channels; Calcium-Transporting ATPases; Carbachol; Cyclic AMP; Diglycerides; Gallopamil; Guinea Pigs; Hydrolysis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Intestine, Small; Isoproterenol; Muscle, Smooth; Protein Kinase C; Receptors, Adrenergic, beta; Receptors, Muscarinic; Ryanodine; Stereoisomerism; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin	1995
Caffeine inhibits the binding of thyrotropin-releasing hormone in GH4C1 pituitary cells. Biochemical and biophysical research communications, 1995, May-25, Volume: 210, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Cell Line; Colforsin; Ionomycin; Kinetics; Nimodipine; Pituitary Gland; Protein Binding; Rats; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone	1995
IBMX induces calcium release from intracellular stores in rat sensory neurones. Cell calcium, 1995, Volume: 17, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Biological Transport; Bucladesine; Caffeine; Calcium; Cell Compartmentation; Colforsin; Cyclic GMP; Dibutyryl Cyclic GMP; Endoplasmic Reticulum; Ganglia, Spinal; Neurons, Afferent; Rats; Theophylline	1995
Effect of different xanthines and phosphodiesterase inhibitors on c-fos expression in rat striatum. Acta physiologica Scandinavica, 1995, Volume: 154, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Administration Schedule; In Situ Hybridization; Male; Neostriatum; Nicotinic Acids; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins c-fos; Purinones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Xanthines	1995
Locomotor activity in mice during chronic treatment with caffeine and withdrawal. Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Caffeine; Dopamine Agents; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Parasympathomimetics; Substance Withdrawal Syndrome; Xanthines	1993
Activation of metabotropic glutamate receptors induces an outward current which is potentiated by methylxanthines in rat cerebellar Purkinje cells. Neuroscience research, 1993, Volume: 16, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cycloleucine; Electrophysiology; Fluorometry; Fura-2; In Vitro Techniques; Ion Channels; Male; Purkinje Cells; Rats; Receptors, Glutamate; Xanthines	1993
Comparative effects of caffeine and selective phosphodiesterase inhibitors on respiration and behavior in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Caffeine; Carbon Dioxide; Conditioning, Psychological; Female; Macaca mulatta; Male; Phosphodiesterase Inhibitors; Quinazolines; Respiration; Triazoles	1993
Multiple effects of caffeine on calcium current in rat ventricular myocytes. Pflugers Archiv : European journal of physiology, 1993, Volume: 424, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium Channels; Egtazic Acid; Heart Ventricles; In Vitro Techniques; Male; Myocardium; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Ryanodine; Sarcoplasmic Reticulum; Theophylline	1993
Effects of caffeine on Ca2+ fluxes and secretion in bovine chromaffin cells. European journal of pharmacology, 1995, Nov-30, Volume: 291, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Adrenal Medulla; Animals; Bucladesine; Caffeine; Calcium; Calcium-Transporting ATPases; Carbachol; Catecholamines; Cattle; Colforsin; Dimethylphenylpiperazinium Iodide; Inositol Phosphates; Nicotinic Agonists; Phosphodiesterase Inhibitors; Terpenes; Thapsigargin; Veratridine	1995
Extensive alteration of fungal gene transcript accumulation and elevation of G-protein-regulated cAMP levels by a virulence-attenuating hypovirus. Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-23, Volume: 93, Issue:15 Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Cyclic AMP; Fungal Proteins; Genes, Fungal; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Polymerase Chain Reaction; RNA Viruses; RNA, Fungal; RNA, Messenger; Signal Transduction; Theophylline; Transcription, Genetic; Virulence; Virus Replication; Xylariales	1996
Effects of caffeine and 3-isobutyl-1-methylxanthine on voltage-activated potassium currents in vertebrate neurones and secretory cells. British journal of pharmacology, 1996, Volume: 118, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; Animals; Autonomic Nervous System; Caffeine; Chick Embryo; Dose-Response Relationship, Drug; Patch-Clamp Techniques; Pineal Gland; Pituitary Gland; Potassium Channels; Rats	1996
Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Acoustic Stimulation; Animals; Caffeine; Convulsants; Dyphylline; Electroencephalography; Epilepsy; Female; Lipid Metabolism; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines	1997
[Effects of beta-adrenergic agonists and phosphodiesterase inhibitors on the outflow facility of the eye]. Nippon Ganka Gakkai zasshi, 1997, Volume: 101, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Animals; Aqueous Humor; Caffeine; Cattle; Cells, Cultured; Dobutamine; Epinephrine; Isoproterenol; Phosphodiesterase Inhibitors; Theophylline; Trabecular Meshwork	1997
Caffeine does not inhibit substance P-evoked intracellular Ca2+ mobilization in rat salivary acinar cells. The American journal of physiology, 1999, Volume: 276, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Bucladesine; Caffeine; Calcium; Cells, Cultured; Fura-2; Kinetics; Male; Rats; Rats, Sprague-Dawley; Submandibular Gland; Substance P	1999
Combined effects of caffeine and prostaglandin E2 on the proliferation of osteoblast-like cells (UMR106-01). Journal of periodontology, 1999, Volume: 70, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Osteoblasts; Periodontitis; Phosphodiesterase Inhibitors; Rats; Risk Factors; Time Factors	1999
Chronic effects of xanthines on levels of central receptors in mice. Cellular and molecular neurobiology, 1999, Volume: 19, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Chemistry; Caffeine; Calcium Channels; Central Nervous System Stimulants; Cerebral Cortex; Corpus Striatum; Drug Interactions; Gene Expression Regulation; Male; Mice; Nerve Tissue Proteins; Pentoxifylline; Radioligand Assay; Receptors, Cholinergic; Receptors, Drug; Receptors, GABA; Receptors, Purinergic P1; Receptors, Serotonin; Theobromine; Theophylline; Xanthines	1999
Cyclic AMP-mediated inhibition of noradrenaline-induced contraction and Ca2+ influx in guinea-pig vas deferens. Experimental physiology, 2000, Volume: 85, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Calcium Channel Blockers; Colforsin; Cyclic AMP; Guinea Pigs; Intracellular Membranes; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Osmolar Concentration; Potassium; Vas Deferens	2000
The effects of caffeine on ATP-sensitive K(+) channels in smooth muscle cells from pig urethra. British journal of pharmacology, 2000, Volume: 131, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; ATP-Binding Cassette Transporters; Caffeine; Central Nervous System Stimulants; Cromakalim; Drug Interactions; Egtazic Acid; Glyburide; KATP Channels; Membrane Potentials; Muscle, Smooth; Potassium Channels; Potassium Channels, Inwardly Rectifying; Ryanodine; Swine; Urethra; Uridine Diphosphate	2000
Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines. Pflugers Archiv : European journal of physiology, 2000, Volume: 440, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Caffeine; Calcium; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Gene Expression; Humans; Magnesium; Membrane Potentials; Nitroprusside; Patch-Clamp Techniques; Potassium Channels; Recombinant Proteins; Theophylline; Transfection; Xanthines	2000
Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells. American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Caffeine; Calcium Channel Blockers; Chlorides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Iodides; Iodine Radioisotopes; Membrane Potentials; Membrane Proteins; ortho-Aminobenzoates; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphorylation; Respiratory Mucosa; Theophylline; Xanthines	2000
The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat. Brain research, 2001, Jan-12, Volume: 888, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Guanylate Cyclase; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Purinones; Radioimmunoassay; Rats; Signal Transduction	2001
An inositol 1,4,5-trisphosphate receptor-gated intracellular Ca(2+) store is involved in regulating sperm hyperactivated motility. Biology of reproduction, 2001, Volume: 65, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; Acrosome Reaction; Animals; Bucladesine; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cattle; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Receptors, Cytoplasmic and Nuclear; Sperm Capacitation; Sperm Motility; Thapsigargin; Thimerosal	2001
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities. The Journal of biological chemistry, 2002, Oct-04, Volume: 277, Issue:40 Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Caffeine; CHO Cells; Cricetinae; Deoxyglucose; Dimerization; Flavins; Glucose; Kinetics; Monosaccharide Transport Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Recombinant Fusion Proteins; Theophylline; Transfection; Triazoles	2002
Studies on the mechanism of enhancement of purinergic transmission by caffeine in the guinea-pig isolated vas deferens. Autonomic & autacoid pharmacology, 2002, Volume: 22, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Excitatory Postsynaptic Potentials; Guinea Pigs; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Purinergic Agonists; Purinergic Antagonists; Receptors, Purinergic; Synaptic Transmission; Vas Deferens	2002
Different signaling pathways in bovine sperm regulate capacitation and hyperactivation. Biology of reproduction, 2004, Volume: 70, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Acrosome Reaction; Animals; Bucladesine; Caffeine; Calcium Signaling; Cattle; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Female; Heparin; In Vitro Techniques; Male; Procaine; Signal Transduction; Sperm Capacitation; Sperm Motility; Sperm-Ovum Interactions	2004
Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slices. American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 291, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Arterioles; Bronchoconstrictor Agents; Caffeine; Calcium; Central Nervous System Stimulants; Colforsin; Cyclic AMP; Enzyme Inhibitors; In Vitro Techniques; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle Contraction; Myocytes, Smooth Muscle; Protein Kinase C; Respiratory System; Ryanodine	2006
Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3). Biochimica et biophysica acta, 2007, Volume: 1768, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Transport Systems; Caco-2 Cells; Caffeine; Dipeptides; Humans; Hydrogen-Ion Concentration; Pentoxifylline; Peptide Transporter 1; Phosphodiesterase Inhibitors; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Symporters; Theophylline	2007
Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study. Clinical hemorheology and microcirculation, 2007, Volume: 36, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Adult; Blood Viscosity; Caffeine; Calcimycin; Calcium; Egtazic Acid; Erythrocyte Aggregation; Hemorheology; Humans; Male; Nifedipine; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Verapamil; Vinca Alkaloids	2007
An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells. Journal of neurochemistry, 2008, Volume: 107, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; Acetamides; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Carotid Body; Catecholamines; Chemoreceptor Cells; Cyclic AMP; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Oxygen; Phenethylamines; Phosphodiesterase Inhibitors; Purines; Rats; Rats, Wistar; Receptor, Adenosine A2B; Receptors, Dopamine D2; Tritium; Vasodilator Agents	2008
Regulation of tyrosine kinase activity during capacitation in goat sperm. Molecular and cellular biochemistry, 2010, Volume: 336, Issue:1-2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies, Phospho-Specific; Caffeine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epididymis; Goats; Male; Organ Specificity; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Protein Subunits; Protein Transport; Protein-Tyrosine Kinases; Signal Transduction; Sperm Capacitation; Sperm Head; Spermatozoa; Tyrosine	2010
Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances. British journal of pharmacology, 2011, Volume: 163, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; ATP-Binding Cassette Transporters; Biological Clocks; Caffeine; Colforsin; Cyclic AMP; Drug Interactions; Female; Glyburide; KATP Channels; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Oviducts; Phosphodiesterase Inhibitors; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors	2011
Caffeine activates tumor suppressor PTEN in sarcoma cells. International journal of oncology, 2011, Volume: 39, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Agents; Caffeine; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colforsin; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Humans; Microfilament Proteins; Models, Biological; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Sarcoma	2011
The novel compound liguzinediol exerts positive inotropic effects in isolated rat heart via sarcoplasmic reticulum Ca2+ ATPase-dependent mechanism. Life sciences, 2012, Oct-05, Volume: 91, Issue:11-12 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart; Male; Myocardial Contraction; Myocytes, Cardiac; Nimodipine; Ouabain; Prazosin; Propranolol; Pyrazines; Rats; Rats, Sprague-Dawley; Ruthenium Red; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin	2012
Regulation of multiple tip formation by caffeine in cellular slime molds. BMC developmental biology, 2012, Aug-28, Volume: 12 Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Cell Transdifferentiation; Chemotactic Factors; Chemotaxis; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dictyostelium; Dipeptides; Gene Expression; Kinetics; Lactams; Phosphodiesterase 4 Inhibitors; Protozoan Proteins	2012
Membrane-permeable tastants amplify β2-adrenergic receptor signaling and delay receptor desensitization via intracellular inhibition of GRK2's kinase activity. Biochimica et biophysica acta, 2015, Volume: 1850, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Blotting, Western; Caffeine; Cell Membrane Permeability; Cyclic AMP; Enzyme Inhibitors; Flavanones; G-Protein-Coupled Receptor Kinase 2; HCT116 Cells; HEK293 Cells; HeLa Cells; Humans; Intracellular Space; Isoproterenol; Isoquinolines; Phosphorylation; Receptors, Adrenergic, beta-2; RNA Interference; Saccharin; Signal Transduction; Sulfonamides; Taste; Tryptophan	2015
Induction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum. Scientific reports, 2017, 03-23, Volume: 7, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Apoptosis; Biosynthetic Pathways; Caffeine; Cyclic AMP; Farnesyl-Diphosphate Farnesyltransferase; Gene Expression Regulation, Fungal; Intramolecular Transferases; Mitochondria; Phosphodiesterase Inhibitors; Reishi; Signal Transduction; Sodium Fluoride; Triterpenes	2017
Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase. Microbiology spectrum, 2023, 08-17, Volume: 11, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Circadian Rhythm; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Neurospora crassa; Protein Kinases; Signal Transduction	2023