Page last updated: 2024-09-02

caffeic acid phenethyl ester and zileuton

caffeic acid phenethyl ester has been researched along with zileuton in 6 studies

Compound Research Comparison

Studies
(caffeic acid phenethyl ester)
Trials
(caffeic acid phenethyl ester)
Recent Studies (post-2010)
(caffeic acid phenethyl ester)
Studies
(zileuton)
Trials
(zileuton)
Recent Studies (post-2010) (zileuton)
840146955164193

Protein Interaction Comparison

ProteinTaxonomycaffeic acid phenethyl ester (IC50)zileuton (IC50)
Prostaglandin E synthaseHomo sapiens (human)0.6
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)1.4782
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)0.9656
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)0.4
Arachidonate 5-lipoxygenase-activating proteinHomo sapiens (human)0.58
Bifunctional epoxide hydrolase 2Homo sapiens (human)0.591
Polyunsaturated fatty acid 5-lipoxygenaseMus musculus (house mouse)0.19
Leukotriene B4 receptor 1Homo sapiens (human)0.42
Cysteinyl leukotriene receptor 2Homo sapiens (human)0.42
Cysteinyl leukotriene receptor 1Homo sapiens (human)0.42

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hashimoto, K; Hasumi, K; Koshino, H; Takahashi, S; Tani, H; Tatefuji, T1
Cai, H; Huang, X; Huang, Y; Jiang, B; Jiang, J; Shen, H; Sun, Y; Wu, X; Xu, J; Xu, S; Yao, H; Zhang, P1
Acevedo-Fuentes, W; Barrias, P; Dahech, P; Mascayano, C; Rojas-Poblete, M; Tirapegui, C; Torrent, C1
Chiasson, A; Cormier, M; Dastous, S; Doiron, JA; Lyons, P; Selka, A; Surette, ME; Touaibia, M; Turcotte, S1
Cuperlovic-Culf, M; Ferguson, D; Hébert, MJ; Jean-François, J; LeBlanc, LM; Morin, P; Paré, AF; Surette, ME; Touaibia, M1
Blanchard, S; Boudreau, LH; Cormier, M; Doucet, MS; Lassalle-Claux, G; Surette, ME; Touaibia, M1

Other Studies

6 other study(ies) available for caffeic acid phenethyl ester and zileuton

ArticleYear
Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Topics: Animals; Anti-Allergic Agents; Bees; Cell Line, Tumor; Cysteine; Histamine; Humans; Leukocytes; Leukotrienes; Propolis; Rhinitis, Allergic, Seasonal

2010
Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.
    European journal of medicinal chemistry, 2016, Jan-27, Volume: 108

    Topics: Antineoplastic Agents; Apoptosis; Arachidonate 5-Lipoxygenase; Caffeic Acids; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Lipoxygenase Inhibitors; Lung Neoplasms; Molecular Structure; Structure-Activity Relationship; Triazoles

2016
Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase.
    Bioorganic & medicinal chemistry letters, 2017, 04-15, Volume: 27, Issue:8

    Topics: Antioxidants; Arachidonate 15-Lipoxygenase; Benzoates; Chemistry Techniques, Synthetic; Glycine max; Humans; Hydrazines; Imides; Lipoxygenase Inhibitors; Molecular Docking Simulation; Oxidation-Reduction; Structure-Activity Relationship

2017
Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.
    European journal of medicinal chemistry, 2019, Oct-01, Volume: 179

    Topics: Antineoplastic Agents; Apoptosis; Arachidonate 5-Lipoxygenase; Carcinoma, Renal Cell; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Kidney Neoplasms; Lipoxygenase Inhibitors; Molecular Structure; Neutrophils; Structure-Activity Relationship

2019
NMR metabolomics analysis of the effects of 5-lipoxygenase inhibitors on metabolism in glioblastomas.
    Journal of proteome research, 2013, May-03, Volume: 12, Issue:5

    Topics: Antineoplastic Agents; Arachidonate 5-Lipoxygenase; Caffeic Acids; Cell Line, Tumor; Drug Screening Assays, Antitumor; Free Radical Scavengers; Glioblastoma; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxyurea; Leukotrienes; Lipid Metabolism; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Metabolome; Metabolomics; Phenylethyl Alcohol; Principal Component Analysis

2013
New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis.
    Mediators of inflammation, 2017, Volume: 2017

    Topics: Arachidonate 5-Lipoxygenase; Caffeic Acids; Coumaric Acids; Enzyme Activation; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Phenylethyl Alcohol; Structure-Activity Relationship

2017