caffeic acid phenethyl ester and tolcapone

caffeic acid phenethyl ester has been researched along with tolcapone in 2 studies

Compound Research Comparison

Studies (caffeic acid phenethyl ester)	Trials (caffeic acid phenethyl ester)	Recent Studies (post-2010) (caffeic acid phenethyl ester)	Studies (tolcapone)	Trials (tolcapone)	Recent Studies (post-2010) (tolcapone)
840	1	469	413	82	132

Protein Interaction Comparison

Protein	Taxonomy	tolcapone (IC50)
Transthyretin	Homo sapiens (human)	3.2
Catechol O-methyltransferase	Homo sapiens (human)	0.043
Catechol O-methyltransferase	Rattus norvegicus (Norway rat)	0.4661
Adenosine receptor A2a	Homo sapiens (human)	0.93
Genome polyprotein	Dengue virus 2 Thailand/16681/84	0.64

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Borges, F; Garrido, J; Martínez, A; Martínez-González, L; Mohamed, T; Pérez, DI; Rao, PP; Remião, F; Serrão, P; Shakeri, A; Silva, T; Soares-da-Silva, P; Uriarte, E; Valente, MJ	1
Borges, F; Mohamed, T; Rao, PPN; Remião, F; Shakeri, A; Silva, T; Soares da Silva, P	1

Other Studies

2 other study(ies) available for caffeic acid phenethyl ester and tolcapone

Article	Year
Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity. Journal of medicinal chemistry, 2016, 08-25, Volume: 59, Issue:16 Topics: Animals; Benzophenones; Blood-Brain Barrier; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Cell Survival; Dose-Response Relationship, Drug; Hepatocytes; Male; Models, Molecular; Molecular Structure; Nitriles; Nitrophenols; Rats; Rats, Wistar; Structure-Activity Relationship; Tolcapone	2016
Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6. European journal of medicinal chemistry, 2019, Apr-01, Volume: 167 Topics: Caffeic Acids; Catechols; Chelating Agents; Copper; Drug Design; Nitro Compounds; Peptides; Phenylethyl Alcohol; Polyphenols; Protein Aggregation, Pathological; Small Molecule Libraries; tau Proteins; Tauopathies	2019

Article

Year

Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity.

Journal of medicinal chemistry, 2016, 08-25, Volume: 59, Issue:16

Topics: Animals; Benzophenones; Blood-Brain Barrier; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Cell Survival; Dose-Response Relationship, Drug; Hepatocytes; Male; Models, Molecular; Molecular Structure; Nitriles; Nitrophenols; Rats; Rats, Wistar; Structure-Activity Relationship; Tolcapone

2016

Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6.

European journal of medicinal chemistry, 2019, Apr-01, Volume: 167

Topics: Caffeic Acids; Catechols; Chelating Agents; Copper; Drug Design; Nitro Compounds; Peptides; Phenylethyl Alcohol; Polyphenols; Protein Aggregation, Pathological; Small Molecule Libraries; tau Proteins; Tauopathies

2019