Page last updated: 2024-09-02

caffeic acid phenethyl ester and indomethacin

caffeic acid phenethyl ester has been researched along with indomethacin in 12 studies

Compound Research Comparison

Studies
(caffeic acid phenethyl ester)
Trials
(caffeic acid phenethyl ester)
Recent Studies (post-2010)
(caffeic acid phenethyl ester)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
840146929,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomycaffeic acid phenethyl ester (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's5 (41.67)29.6817
2010's4 (33.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Backlund, A; Bohlin, L; Gottfries, J; Larsson, J1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
El-Kabbani, O; Endo, S; Hara, A; Kanamori, A; Matsunaga, T; Nagai, H; Ohta, S; Otsuji, Y; Sundaram, K; Toyooka, N1
Bennis, K; Ducki, S; Lesage, F; Vivier, D1
Kongsaeree, P; Lhinhatrakool, T; Prabpai, S; Seeka, C; Sutthivaiyakit, S; Tewtrakul, S1
Chen, Y; Feng, F; Guo, Q; He, S; Liu, W; Liu, Y; Sun, H; Zhao, L1
Calder, PC; Mirzoeva, OK1
Carothers, AM; Dannenberg, AJ; Grunberger, D; Koboldt, C; Masferrer, JL; Mestre, JR; Michaluart, P; Sacks, PG; Subbaramaiah, K; Tanabe, T; Zweifel, BS1
Aydin, E; Borazan, M; Cekiç, O; Cihan Dağloğlu, M; Dağlioğlu, K; Gültek, A; Totan, Y1
Borrelli, F; Cardile, V; Gentile, B; Panico, A; Russo, A1
Al-Anati, L; Katz, N; Petzinger, E1
Bucolo, C; Drago, F; Modica, MN; Pittalà, V; Romano, GL; Romeo, G; Salerno, L; Salomone, S; Siracusa, MA1

Reviews

2 review(s) available for caffeic acid phenethyl ester and indomethacin

ArticleYear
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
    Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

    Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship

2016
Overview of AKR1C3: Inhibitor Achievements and Disease Insights.
    Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20

    Topics: Aldo-Keto Reductase Family 1 Member C3; Antineoplastic Agents; Binding Sites; Cell Proliferation; Clinical Trials as Topic; Drug Development; Drug Resistance, Neoplasm; Humans; Models, Molecular; Molecular Structure; Neoplasms; Treatment Outcome

2020

Other Studies

10 other study(ies) available for caffeic acid phenethyl ester and indomethacin

ArticleYear
Expanding the ChemGPS chemical space with natural products.
    Journal of natural products, 2005, Volume: 68, Issue:7

    Topics: Biological Products; Combinatorial Chemistry Techniques; Computer Graphics; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship

2005
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis.
    Journal of natural products, 2012, Apr-27, Volume: 75, Issue:4

    Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Brazil; Crystallography, X-Ray; Humans; Hydroxyprostaglandin Dehydrogenases; Male; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Propolis; Stereoisomerism; Trichothecenes

2012
Anti-inflammatory 12,20-Epoxypregnane and 11,12-seco-Pregnane Glycosides from the Stems of Hoya kerrii.
    Journal of natural products, 2017, 06-23, Volume: 80, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Apocynaceae; Crystallography, X-Ray; Cyclooxygenase 2; Dose-Response Relationship, Drug; Glycosides; Inhibitory Concentration 50; Lipopolysaccharides; Macrophages; Mice; Molecular Conformation; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Nuclear Magnetic Resonance, Biomolecular; Plant Stems; Pregnanes; Thailand

2017
The effect of propolis and its components on eicosanoid production during the inflammatory response.
    Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 55, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic Acid; Caffeic Acids; Cyclooxygenase Inhibitors; Diet; Eicosanoids; Flavanones; Flavonoids; Indomethacin; Inflammation; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Male; Masoprocol; Mice; Mice, Inbred C57BL; Peritoneal Cavity; Phenylethyl Alcohol; Propolis; Quercetin; Urea; Zymosan

1996
Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation.
    Cancer research, 1999, May-15, Volume: 59, Issue:10

    Topics: Air; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Arachidonic Acids; Caffeic Acids; Calcimycin; Carcinoma, Squamous Cell; Carrageenan; Cell Membrane; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Activation; Enzyme Induction; Epithelial Cells; Genetic Vectors; Humans; Indomethacin; Inflammation; Ionophores; Isoenzymes; Male; Membrane Lipids; Membrane Proteins; Mouth Mucosa; Nucleopolyhedroviruses; Phenylethyl Alcohol; Phospholipids; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured

1999
Effect of caffeic acid phenethyl ester on corneal neovascularization in rats.
    Current eye research, 2001, Volume: 23, Issue:4

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Caffeic Acids; Cornea; Corneal Neovascularization; Dexamethasone; Glucocorticoids; Indomethacin; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley

2001
Effect of propolis on human cartilage and chondrocytes.
    Life sciences, 2003, Jul-11, Volume: 73, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Caffeic Acids; Cartilage; Cartilage, Articular; Cell Separation; Cells, Cultured; Chondrocytes; Glycosaminoglycans; Humans; Indomethacin; Nitric Oxide; Nitrites; Organ Culture Techniques; Phenylethyl Alcohol; Propolis

2003
Interference of arachidonic acid and its metabolites with TNF-alpha release by ochratoxin A from rat liver.
    Toxicology, 2005, Mar-30, Volume: 208, Issue:3

    Topics: Animals; Arachidonic Acid; Aristolochic Acids; Caffeic Acids; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Liver; Male; NF-kappa B; Ochratoxins; Phenylethyl Alcohol; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha

2005
Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation.
    European journal of pharmacology, 2015, Apr-05, Volume: 752

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeic Acids; Eye Diseases; Indomethacin; Inflammation; Male; Phenylethyl Alcohol; Rabbits

2015