Page last updated: 2024-09-02

caffeic acid phenethyl ester and curcumin

caffeic acid phenethyl ester has been researched along with curcumin in 17 studies

Compound Research Comparison

Studies
(caffeic acid phenethyl ester)
Trials
(caffeic acid phenethyl ester)
Recent Studies (post-2010)
(caffeic acid phenethyl ester)
Studies
(curcumin)
Trials
(curcumin)
Recent Studies (post-2010) (curcumin)
840146916,33659312,705

Protein Interaction Comparison

ProteinTaxonomycaffeic acid phenethyl ester (IC50)curcumin (IC50)
toll-like receptor 9Homo sapiens (human)8.362
TPA: protein transporter TIM10Saccharomyces cerevisiae S288C19.7
intestinal alkaline phosphatase precursorMus musculus (house mouse)18.7
perilipin-1Homo sapiens (human)9.167
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)9.167
hypothetical protein SA1422Staphylococcus aureus subsp. aureus N31542.9
Prostaglandin E synthaseHomo sapiens (human)1.8
Lysine-specific histone demethylase 1AHomo sapiens (human)9.6
D-amino-acid oxidaseSus scrofa (pig)1.07
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)3
Amyloid-beta precursor proteinHomo sapiens (human)4.3079
Neuronal proto-oncogene tyrosine-protein kinase Src Mus musculus (house mouse)2.2
Heme oxygenase 1 Rattus norvegicus (Norway rat)10
Microtubule-associated protein tauHomo sapiens (human)3.25
60 kDa heat shock protein, mitochondrialHomo sapiens (human)8.3
Tissue factorHomo sapiens (human)0.0132
TyrosinaseHomo sapiens (human)5
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)5.4
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Homo sapiens (human)7
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)0.066
Amine oxidase [flavin-containing] AHomo sapiens (human)3.5
Heme oxygenase 2Rattus norvegicus (Norway rat)10
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)5.4
Amine oxidase [flavin-containing] BHomo sapiens (human)2.5733
Proteasome subunit beta type-5Homo sapiens (human)10
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)1.73
Alpha-synucleinHomo sapiens (human)0.22
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)5.4
10 kDa heat shock protein, mitochondrialHomo sapiens (human)8.3
Histone acetyltransferase p300Homo sapiens (human)6.5
60 kDa chaperonin Escherichia coli3
10 kDa chaperonin Escherichia coli3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3Homo sapiens (human)7
Cysteine protease Trypanosoma brucei rhodesiense7.75
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)2.36
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.63
Beta lactamase (plasmid)Pseudomonas aeruginosa7.751

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's6 (35.29)29.6817
2010's7 (41.18)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Ahn, MR; Maruta, H1
Burke, TR; Mazumder, A; Neamati, N; Pommier, Y; Sunder, S; Zhao, H1
Farrow, S; Holloway, KA; Howells, L; Kaptein, A; Manson, MM; Munks, RJ; Plummer, SM1
Calabrese, V; Foresti, R; Giuffrida Stella, AM; Green, CJ; Motterlini, R; Scapagnini, G1
Alam, J; Balogun, E; Foresti, R; Gong, P; Green, CJ; Hoque, M; Killeen, E; Motterlini, R1
Blijlevens, NM; de Witte, TJ; Donnelly, JP; M'Rabet, L; Marteijn, J; Timal, S; van't Land, B1
Hitsuda, Y; Igishi, T; Kodani, M; Matsumoto, S; Nakanishi, H; Shigeoka, Y; Shimizu, E; Yasuda, K1
Foresti, R; Green, CJ; Hoque, M; Monti, D; Motterlini, R1
Nagasaka, R; Ohara, K; Ohshima, T; Uchida, A; Ushio, H1
Calabrese, V; Caruso, C; Scapagnini, G1
Chuu, CP; Kuo, LK; Lin, HP1
Kim, SJ; Lee, ES; Nam, JH; Shin, DH; Zhang, Y1
Choe, H; Choi, SW; Kim, KS; Kim, SJ; Kim, WK; Ko, TH; Shin, DH; Yoo, HY; Youm, JB; Zhang, YH1
Chen, Q; Fu, W; Lei, Y; Ren, X; Wang, H; Yu, H1
Musa, AE; Shabeeb, D1
Khare, S; Khare, T; Palakurthi, S; Palakurthi, SS; Shah, BM1
Manzanilla, B; Robles, J1

Reviews

3 review(s) available for caffeic acid phenethyl ester and curcumin

ArticleYear
From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy.
    European journal of medicinal chemistry, 2017, Dec-15, Volume: 142

    Topics: Animals; Antineoplastic Agents; Click Chemistry; Drug Discovery; Humans; Longevity; Neoplasms; p21-Activated Kinases; Protein Kinase Inhibitors

2017
Radiation-Induced Heart Diseases: Protective Effects of Natural Products.
    Medicina (Kaunas, Lithuania), 2019, May-09, Volume: 55, Issue:5

    Topics: Biological Products; Caffeic Acids; Curcumin; Drug Combinations; Drugs, Chinese Herbal; Guaiacol; Heart Diseases; Hesperidin; Humans; Melatonin; Phenylethyl Alcohol; Protective Factors; Radiation Injuries; Selenium; Vitis

2019
Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease.
    International journal of molecular sciences, 2020, May-31, Volume: 21, Issue:11

    Topics: Animals; Benzoquinones; Biological Products; Biomimetics; Caffeic Acids; Curcumin; Cytokines; Exosomes; Humans; Inflammation; Inflammatory Bowel Diseases; Insecta; Macromolecular Substances; Nanomedicine; Oxidative Stress; Phenylethyl Alcohol; Phytochemicals; Plant Extracts; Polysaccharides; Quercetin; Resveratrol; Stilbenes; Transcription Factors; Translational Research, Biomedical; Vasoactive Intestinal Peptide; Zingiber officinale

2020

Other Studies

14 other study(ies) available for caffeic acid phenethyl ester and curcumin

ArticleYear
Arylamide inhibitors of HIV-1 integrase.
    Journal of medicinal chemistry, 1997, Apr-11, Volume: 40, Issue:8

    Topics: Caffeic Acids; Chromatography, High Pressure Liquid; Curcumin; Cytotoxins; Dose-Response Relationship, Drug; Enzyme Inhibitors; HIV Integrase; HIV Integrase Inhibitors; NF-kappa B; Phenylethyl Alcohol; Quinones; Structure-Activity Relationship

1997
Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex.
    Oncogene, 1999, Oct-28, Volume: 18, Issue:44

    Topics: Antineoplastic Agents; Caffeic Acids; Colonic Neoplasms; Curcumin; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; I-kappa B Kinase; I-kappa B Proteins; Isoenzymes; Membrane Proteins; NF-kappa B; NF-kappaB-Inducing Kinase; Phenylethyl Alcohol; Polyenes; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

1999
Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers.
    Molecular pharmacology, 2002, Volume: 61, Issue:3

    Topics: Acetylcysteine; Animals; Astrocytes; Caffeic Acids; Cell Survival; Cells, Cultured; Curcumin; Drug Interactions; Enzyme Activation; Enzyme Induction; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Phenylethyl Alcohol; Rats; Up-Regulation

2002
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.
    The Biochemical journal, 2003, May-01, Volume: 371, Issue:Pt 3

    Topics: Animals; Antioxidants; Blotting, Western; Caffeic Acids; Carrier Proteins; Curcumin; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); LLC-PK1 Cells; NF-E2-Related Factor 2; Phenylethyl Alcohol; Promoter Regions, Genetic; Trans-Activators

2003
Role of curcumin and the inhibition of NF-kappaB in the onset of chemotherapy-induced mucosal barrier injury.
    Leukemia, 2004, Volume: 18, Issue:2

    Topics: Animals; Antineoplastic Agents; Caffeic Acids; Cell Line; Curcumin; Cytarabine; Drug Interactions; Female; Intestinal Mucosa; Methotrexate; NF-kappa B; Phenylethyl Alcohol; Rats; Rats, Inbred Strains

2004
Sulindac sulfide and caffeic acid phenethyl ester suppress the motility of lung adenocarcinoma cells promoted by transforming growth factor-beta through Akt inhibition.
    Journal of cancer research and clinical oncology, 2004, Volume: 130, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Caffeic Acids; Catechin; Cell Movement; Curcumin; Humans; Lung Neoplasms; Neovascularization, Pathologic; NF-kappa B; Phenylethyl Alcohol; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sulindac; Transforming Growth Factor beta; Tumor Cells, Cultured

2004
Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Animals; Aurintricarboxylic Acid; Caffeic Acids; Cattle; Cell Survival; Chalcone; Chalcones; Curcumin; Endothelial Cells; Enzyme Activation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Mitogen-Activated Protein Kinases; Oxidative Stress; Phenylethyl Alcohol

2005
The effects of hydroxycinnamic acid derivatives on adiponectin secretion.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2009, Volume: 16, Issue:2-3

    Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Caffeic Acids; Coumaric Acids; Curcumin; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Interferon-gamma; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Phenylethyl Alcohol; Phenylpropionates; Phytotherapy; Pioglitazone; Plant Extracts; Plant Oils; Rice Bran Oil; Thiazolidinediones; Tumor Necrosis Factor-alpha

2009
Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders.
    Advances in experimental medicine and biology, 2010, Volume: 698

    Topics: Aging; Antioxidants; Brain; Caffeic Acids; Catechin; Curcumin; Diet; Flavonoids; Neurodegenerative Diseases; Neuroprotective Agents; Phenols; Phenylethyl Alcohol; Polyphenols

2010
Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:1

    Topics: Antineoplastic Agents; Biological Availability; Caffeic Acids; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromones; Curcuma; Curcumin; Drug Therapy, Combination; Enzyme Inhibitors; ErbB Receptors; Humans; Morpholines; NF-kappa B; Phenylethyl Alcohol; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Pyrimidines; Quinazolines; Receptors, Fibroblast Growth Factor; Signal Transduction; Somatomedins; Tyrphostins

2012
Inhibition of Ca(2+) release-activated Ca(2+) channel (CRAC) by curcumin and caffeic acid phenethyl ester (CAPE) via electrophilic addition to a cysteine residue of Orai1.
    Biochemical and biophysical research communications, 2012, Nov-09, Volume: 428, Issue:1

    Topics: Caffeic Acids; Calcium; Calcium Channels; Curcumin; Cysteine; HEK293 Cells; Humans; Mutation; ORAI1 Protein; Phenylethyl Alcohol

2012
Class 3 inhibition of hERG K+ channel by caffeic acid phenethyl ester (CAPE) and curcumin.
    Pflugers Archiv : European journal of physiology, 2013, Volume: 465, Issue:8

    Topics: Action Potentials; Caffeic Acids; Curcumin; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Kinetics; Phenylethyl Alcohol; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2013
Neuroprotective effect of three caffeic acid derivatives via ameliorate oxidative stress and enhance PKA/CREB signaling pathway.
    Behavioural brain research, 2017, 06-15, Volume: 328

    Topics: Animals; Avoidance Learning; Caffeic Acids; Cell Survival; Curcumin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Galactose; Hydrogen Peroxide; Lactates; Maze Learning; Mice; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Phenylethyl Alcohol; Random Allocation; Rats; Signal Transduction; Spatial Memory

2017
Antiradical properties of curcumin, caffeic acid phenethyl ester, and chicoric acid: a DFT study.
    Journal of molecular modeling, 2022, Feb-26, Volume: 28, Issue:3

    Topics: Caffeic Acids; Curcumin; Phenylethyl Alcohol; Succinates

2022