cadinol and zingiberene

This study aimed to investigate the chemical composition of essential oils isolated from Acca sellowiana (feijoa) leaves and stems and elaborate on their relevance as natural anti-aging, coupled with molecular-docking studies. The isolated oils were analysed using gas chromatography-mass spectrometry analysis and investigated for inhibitory effects against acetylcholinesterase, β-secretase, collagenase, elastase and tyrosinase. Molecular-modelling study was performed using MOE-Dock program to evaluate binding interactions of major components with the above-mentioned targets. The leaf oil revealed the predominance of caryophyllene oxide (24.3 %), linalool (7.9 %), and spathulenol (6.6 %), while the stem oil was presented by caryophyllene oxide (38.1 %), α-zingiberene (10.1 %) and humulene oxide II (6.0 %). The stem oil expressed superior inhibitory activities against acetylcholinesterase (IC

Topics: Acetylcholinesterase; Acyclic Monoterpenes; Amyloid Precursor Protein Secretases; Feijoa; Molecular Docking Simulation; Monocyclic Sesquiterpenes; Monophenol Monooxygenase; Oils, Volatile; Oxides; Pancreatic Elastase; Plant Leaves; Polycyclic Sesquiterpenes; Sesquiterpenes; Terpenes