cadinane and drimane

cadinane has been researched along with drimane* in 1 studies

Other Studies

1 other study(ies) available for cadinane and drimane

ArticleYear
Cadinane- and drimane-type sesquiterpenoids produced by Paecilomyces sp. TE-540, an endophyte from Nicotiana tabacum L., are acetylcholinesterase inhibitors.
    Bioorganic chemistry, 2020, Volume: 104

    Sesquiterpenoids with diverse skeleton types are regarded as potential lead compounds in pharmacological and other applications. Herein, we report the discovery of two new cadinane-type sesquiterpenoids, paecilacadinol A (1) and B (2); two new drimane-type sesquiterpenoids, ustusol D (3) and ustusol E (4); and six known analogs (5-10) from the endophytic fungus Paecilomyces sp. TE-540, enriching the structural diversity of naturally occurring sesquiterpenoids. Their planar structures were determined on the basis of detailed interpretation of 1D and 2D NMR spectroscopy and HRESIMS data, while their stereochemical structures were established by X-ray crystallographic analyses for 1 and 3-8 and theoretical calculations for 2. Notably, compounds 1 and 2 represent novel examples of cadinane-type sesquiterpenoids with ether bonds formed by intramolecular dehydration. Compounds 5 and 6 showed moderate activities against acetylcholinesterase (AChE), with IC

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Molecular Structure; Nicotiana; Paecilomyces; Polycyclic Sesquiterpenes; Sesquiterpenes; Structure-Activity Relationship

2020