c2-mycophenolic-adenine-dinucleotide and tiazofurin
c2-mycophenolic-adenine-dinucleotide has been researched along with tiazofurin* in 1 studies
Other Studies
1 other study(ies) available for c2-mycophenolic-adenine-dinucleotide and tiazofurin
| Article | Year |
|---|---|
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
Novel tiazofurin adenine dinucleotide (TAD) analogues 25-33 containing a substituent at C2 of the adenine ring have been synthesized as inhibitors of the two isoforms of human IMP-dehydrogenase. The 2-ethyl TAD analogue 33 [Ki = 1 nM (type I), Ki = 14 nM (type II)] was found to be the most potent. It did not inhibit three other cellular dehydrogenases up to 50 microM. Mycophenolic adenine bis(phosphonate)s containing a 2-phenyl (37) or 2-ethyl group (38), were prepared as metabolically stable compounds, both nanomolar inhibitors. Compound 38 [Ki = 16 nM (type I), Ki = 38 nM (type II)] inhibited proliferation of leukemic K562 cells (IC50 = 1.1 microM) more potently than tiazofurin (IC50 = 12.4 microM) or mycophenolic acid (IC50 = 7.7 microM). Topics: Adenosine Monophosphate; Antineoplastic Agents; Diphosphonates; Drug Screening Assays, Antitumor; Humans; IMP Dehydrogenase; Isoenzymes; K562 Cells; Models, Molecular; Mycophenolic Acid; NAD; Protein Binding; Ribavirin | 2007 |