Compounds > c 1311
Page last updated: 2024-09-03

c 1311 and triazoles

c 1311 has been researched along with triazoles in 7 studies

Compound Research Comparison

Studies
(c 1311)		Trials
(c 1311)		Recent Studies (post-2010)
(c 1311)		Studies
(triazoles)		Trials
(triazoles)		Recent Studies (post-2010) (triazoles)
5212325,8082,25213,501

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Assaraf, YG; Bram, EE; Grimberg, M; Ifergan, I; Lemke, K; Skladanowski, A1
Fedejko-Kap, B; Mazerska, Z; Niemira, M; Radominska-Pandya, A1
Mazerska, Z; Nowicka, AM; Stojek, Z; Zabost, E1
Bratton, SM; Fedejko-Kap, B; Finel, M; Mazerska, Z; Radominska-Pandya, A1
Augustin, E; Chambers, TC; Chu, R; Fedejko-Kap, B; Mazerska, Z; Pawlowska, M; Radominska-Pandya, A1
Bejrowska, A; Mazerska, Z; Mróz, A; Pawłowska, M1
Augustin, E; Kwaśniewska, A; Mazerska, Z; Pawłowska, M1

Other Studies

7 other study(ies) available for c 1311 and triazoles

ArticleYear
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
    Biochemical pharmacology, 2007, Jun-30, Volume: 74, Issue:1

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Amplification; Gene Expression Regulation, Neoplastic; Heterozygote; Humans; Indoles; Irinotecan; Mitoxantrone; Neoplasm Proteins; RNA, Messenger; Triazoles

2007
Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells.
    Xenobiotica; the fate of foreign compounds in biological systems, 2011, Volume: 41, Issue:12

    Topics: Acridines; Aminoacridines; Animals; Antineoplastic Agents; Biocatalysis; Biotransformation; Cell Hypoxia; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Microsomes, Liver; Oxygenases; Rats; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Tissue Donors; Triazoles

2011
Influence of temperature and interactions with ligands on dissociation of dsDNA and ligand-dsDNA complexes of various types of binding. An electrochemical study.
    Physical chemistry chemical physics : PCCP, 2012, Mar-14, Volume: 14, Issue:10

    Topics: Acridines; Aminoacridines; Animals; Binding Sites; Bisbenzimidazole; Cattle; DNA; Electrochemistry; Ligands; Molecular Structure; Nucleic Acid Denaturation; Organometallic Compounds; Temperature; Triazoles

2012
Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:9

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Glucuronides; Glucuronosyltransferase; Humans; Intestines; Kinetics; Liver; Microsomes, Liver; Models, Biological; Mutation; Recombinant Proteins; Substrate Specificity; Triazoles

2012
Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:2

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; Biotransformation; Cell Survival; Dose-Response Relationship, Drug; Female; Glucuronides; Glucuronosyltransferase; HeLa Cells; Humans; Inhibitory Concentration 50; Transfection; Triazoles; Uterine Cervical Neoplasms

2013
Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:3

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Glucuronides; Glucuronosyltransferase; Hep G2 Cells; HT29 Cells; Humans; Irinotecan; Isoenzymes; Microsomes, Liver; Triazoles

2018
Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs' Cytotoxicity, Metabolism and Cellular Response.
    International journal of molecular sciences, 2020, May-31, Volume: 21, Issue:11

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; Apoptosis; Biotransformation; Cell Line, Tumor; Cytochrome P-450 CYP3A; Drug Design; Drug Screening Assays, Antitumor; Glucuronides; Glucuronosyltransferase; HCT116 Cells; Humans; Isoenzymes; MCF-7 Cells; Membrane Potential, Mitochondrial; Necrosis; Substrate Specificity; Triazoles

2020