c 1311 has been researched along with acridines in 9 studies
| Studies (c 1311) | Trials (c 1311) | Recent Studies (post-2010) (c 1311) | Studies (acridines) | Trials (acridines) | Recent Studies (post-2010) (acridines) |
|---|---|---|---|---|---|
| 52 | 1 | 23 | 6,987 | 169 | 856 |
| Protein | Taxonomy | c 1311 (IC50) | acridines (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | 6.84 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Mazerska, Z | 1 |
| Assaraf, YG; Bram, EE; Grimberg, M; Ifergan, I; Lemke, K; Skladanowski, A | 1 |
| Adar, Y; Assaraf, YG; Bram, EE; Mesika, N; Sabisz, M; Skladanowski, A | 1 |
| Fedejko-Kap, B; Mazerska, Z; Niemira, M; Radominska-Pandya, A | 1 |
| Mazerska, Z; Nowicka, AM; Stojek, Z; Zabost, E | 1 |
| Bratton, SM; Fedejko-Kap, B; Finel, M; Mazerska, Z; Radominska-Pandya, A | 1 |
| Augustin, E; Chambers, TC; Chu, R; Fedejko-Kap, B; Mazerska, Z; Pawlowska, M; Radominska-Pandya, A | 1 |
| Bejrowska, A; Mazerska, Z; Mróz, A; Pawłowska, M | 1 |
| Augustin, E; Kwaśniewska, A; Mazerska, Z; Pawłowska, M | 1 |
9 other study(ies) available for c 1311 and acridines
| Article | Year |
|---|---|
Similarity between enzymatic and electrochemical oxidation of 2-hydroxyacridinone, the reference compound of antitumor imidazoacridinones.
Topics: Acridines; Aminoacridines; Antineoplastic Agents; Biotransformation; Chromatography, High Pressure Liquid; Electrochemistry; Horseradish Peroxidase; Hydrogen Peroxide; Oxidation-Reduction; Reference Values; Spectrophotometry, Ultraviolet | 2003 |
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
Topics: Acridines; Aminoacridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Amplification; Gene Expression Regulation, Neoplastic; Heterozygote; Humans; Indoles; Irinotecan; Mitoxantrone; Neoplasm Proteins; RNA, Messenger; Triazoles | 2007 |
Structural determinants of imidazoacridinones facilitating antitumor activity are crucial for substrate recognition by ABCG2.
Topics: Acridines; Aminoacridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Structure-Activity Relationship | 2009 |
Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells.
Topics: Acridines; Aminoacridines; Animals; Antineoplastic Agents; Biocatalysis; Biotransformation; Cell Hypoxia; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Microsomes, Liver; Oxygenases; Rats; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Tissue Donors; Triazoles | 2011 |
Influence of temperature and interactions with ligands on dissociation of dsDNA and ligand-dsDNA complexes of various types of binding. An electrochemical study.
Topics: Acridines; Aminoacridines; Animals; Binding Sites; Bisbenzimidazole; Cattle; DNA; Electrochemistry; Ligands; Molecular Structure; Nucleic Acid Denaturation; Organometallic Compounds; Temperature; Triazoles | 2012 |
Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
Topics: Acridines; Aminoacridines; Antineoplastic Agents; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Glucuronides; Glucuronosyltransferase; Humans; Intestines; Kinetics; Liver; Microsomes, Liver; Models, Biological; Mutation; Recombinant Proteins; Substrate Specificity; Triazoles | 2012 |
Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
Topics: Acridines; Aminoacridines; Antineoplastic Agents; Biotransformation; Cell Survival; Dose-Response Relationship, Drug; Female; Glucuronides; Glucuronosyltransferase; HeLa Cells; Humans; Inhibitory Concentration 50; Transfection; Triazoles; Uterine Cervical Neoplasms | 2013 |
Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
Topics: Acridines; Aminoacridines; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Glucuronides; Glucuronosyltransferase; Hep G2 Cells; HT29 Cells; Humans; Irinotecan; Isoenzymes; Microsomes, Liver; Triazoles | 2018 |
Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs' Cytotoxicity, Metabolism and Cellular Response.
Topics: Acridines; Aminoacridines; Antineoplastic Agents; Apoptosis; Biotransformation; Cell Line, Tumor; Cytochrome P-450 CYP3A; Drug Design; Drug Screening Assays, Antitumor; Glucuronides; Glucuronosyltransferase; HCT116 Cells; Humans; Isoenzymes; MCF-7 Cells; Membrane Potential, Mitochondrial; Necrosis; Substrate Specificity; Triazoles | 2020 |