Compounds > bw a868c
Page last updated: 2024-09-03

bw a868c and indomethacin

bw a868c has been researched along with indomethacin in 4 studies

Compound Research Comparison

Studies
(bw a868c)		Trials
(bw a868c)		Recent Studies (post-2010)
(bw a868c)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
4701129,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomybw a868c (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hamid-Bloomfield, S; Payne, AN; Petrovic, AA; Whittle, BJ1
Loi, RK; Warren, JB; Wilson, AJ1
Ohinata, K; Usui, H; Yoshikawa, M; Zhao, H1
Miyamoto, C; Mizushige, T; Ohinata, K; Yoshida, M; Yoshikawa, M1

Other Studies

4 other study(ies) available for bw a868c and indomethacin

ArticleYear
The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C.
    British journal of pharmacology, 1990, Volume: 100, Issue:4

    Topics: Administration, Inhalation; Anesthesia; Animals; Benzeneacetamides; Bronchi; Cyclooxygenase Inhibitors; Guinea Pigs; Hydantoins; Hydroxamic Acids; Indomethacin; Lipoxygenase Inhibitors; Male; Platelet Aggregation Inhibitors; Prostaglandin D2; Prostaglandins D; Receptors, Prostaglandin; Respiratory Function Tests; Sulfonamides; Thromboxane A2; Vagotomy

1990
PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation.
    The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 2

    Topics: Acetylcholine; Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Arachidonic Acid; Arginine; Bradykinin; Dinoprostone; Hydantoins; Indomethacin; Male; Microcirculation; Models, Cardiovascular; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Platelet Aggregation Inhibitors; Prostaglandin D2; Rabbits; Regional Blood Flow; Skin

1994
Met-Arg-Trp derived from Rubisco lowers blood pressure via prostaglandin D(2)-dependent vasorelaxation in spontaneously hypertensive rats.
    Peptides, 2008, Volume: 29, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Drug Administration Schedule; Hydantoins; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Peptides; Prostaglandin D2; Rats; Rats, Inbred SHR; Ribulose-Bisphosphate Carboxylase; Transcription Factor DP1; Vasodilation

2008
Complement C5a exhibits anxiolytic-like activity via the prostaglandin D2-DP1 receptor system coupled to adenosine A2A and GABAA receptors.
    Prostaglandins & other lipid mediators, 2012, Volume: 98, Issue:1-2

    Topics: Animals; Anti-Anxiety Agents; Bicuculline; Complement C5a; Hydantoins; Indomethacin; Male; Mice; Receptor, Adenosine A2A; Receptors, GABA-A; Receptors, Immunologic; Receptors, Prostaglandin

2012