bw-755c has been researched along with indomethacin in 206 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 145 (70.39) | 18.7374 |
| 1990's | 56 (27.18) | 18.2507 |
| 2000's | 5 (2.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fruchtmann, R; Hammond, MD; Hanko, R; Pfitzner, J; Place, GA | 1 |
| Farina, PR; Graham, AG; Lazer, ES; Possanza, GJ; Wong, HC | 1 |
| Chakrabarti, JK; Eggleton, RJ; Gallagher, PT; Harvey, J; Hicks, TA; Kitchen, EA; Smith, CW | 1 |
| Hopper, AT; Witiak, DT; Ziemniak, J | 1 |
| Emeis, JJ; Van den Hoogen, CM | 1 |
| Fukushima, T; Sasaki, H; Sekizawa, K; Takishima, T; Yamauchi, K; Yamaya, M; Zayasu, K | 1 |
| Guivarc'h, P; Iliou, JP; Jourd'heuil, D; Robin, F; Serkiz, B; Vilaine, JP; Volland, JP | 1 |
| Cottam, GL; Miller, BC; Uyeda, K | 1 |
| Chapkin, RS; Lee, DY; Lupton, JR | 1 |
| Drews, G; Garrino, MG; Henquin, JC | 1 |
| Cohen, RH; Perl, ER | 2 |
| Braquet, P; Lagente, V; Mencia-Huerta, JM; Pons, F; Touvay, C | 1 |
| Drapeau, G; Jukic, D; Regoli, D; Rhaleb, NE; Rouissi, N | 1 |
| Ishizaki, Y; Murota, S | 1 |
| Fry, CH; Keirse, MJ; Noort, WA; Quartero, HW | 1 |
| Ebbesen, MA; Gibel, L; Goodwin, JS; Harford, AM; Shopp, GM; Smith, AY; Sterling, WA | 1 |
| Lonigro, AJ; Sprague, RS; Stephenson, AH | 1 |
| Besser, GM; Faria, MS; Grossman, AB; Navarra, P; Rees, LH; Tsagarakis, S | 1 |
| Morita, I; Murota, S; Okiji, T; Sunada, I | 1 |
| Campbell, WB; Falck, JR; Pfister, SL | 1 |
| Beraud, M; Cambon, C; Didier, A; Forgue, MF; Pinelli, E; Pipy, B; Souqual, MC; Vandaele, J | 1 |
| McGiff, JC; Oyekan, AO; Quilley, J | 1 |
| Hirota, K; Ikegami, H; Kadowaki, K; Koike, K; Miyake, A; Ohmichi, M; Tanizawa, O; Yamaguchi, M | 1 |
| Calixto, JB; Cruz, AB; Medeiros, YS; Yunes, RA; Zanini Júnior, JC | 1 |
| Quilley, J; Sarubbi, D | 1 |
| Becherucci, C; Mugridge, KG; Parente, L; Perretti, M | 1 |
| Espey, LL; Kawano, T; Okamura, H; Tanaka, N | 1 |
| Antunes, E; Cirino, G; de Nucci, G; Levi, S; Mariano, M | 1 |
| Ohnishi, T; Posner, JB; Shapiro, WR; Sher, PB | 1 |
| Myers, AK; Price, RM; Robey, JW | 1 |
| Laychock, SG | 1 |
| Bethel, RA; McClure, CL | 1 |
| Leyck, S; Parnham, MJ | 1 |
| Dikshit, M; Srimal, RC | 1 |
| Bhattacherjee, P; Guo, A; Kulkarni, P; Ohia, E; Xu, JT | 1 |
| Linssen, MJ; Lipponer, L; Seilnacht, W; Wilhelms, OH | 1 |
| Gustafsson, LE; Hedqvist, P; Ohlén, A; Wiklund, CU; Wiklund, NP | 1 |
| Conroy, MC; Kennedy, JA; Thueson, DO | 1 |
| Fennessy, MR; Stewart, AG; Thompson, DC | 1 |
| Creese, BR; Temple, DM | 1 |
| Boctor, AM; Pugsley, TA | 1 |
| Baethmann, A; Hammersen, F; Unterberg, A; Wahl, M | 1 |
| Browning, JL; Cirino, G; Flower, RJ; Peers, SH; Pepinsky, RB | 1 |
| Hambleton, P; Miller, P | 1 |
| Müller, B; Schmidtke, M; Witt, W | 1 |
| Carroll, MA; Rosenthal, WS; Schwartzman, ML; Stahl, RE; Stein, BE | 1 |
| Behrens, TW; Goodwin, JS; Lianos, EA; Lum, LG | 1 |
| Boughton-Smith, NK; Hutcheson, I; Whittle, BJ | 1 |
| Boukili, MA; Bureau, MF; Lefort, J; Lellouch-Tubiana, A; Simon, MT; Vargaftig, BB | 1 |
| Bjertnaes, L; Kjaeve, J; Vaage, J | 1 |
| Azizova, OA; Borin, ML; Ivanova, MA; Khodorov, BI; Markov, CM; Pinelis, VG | 1 |
| Klaas, M; Wadsworth, R | 1 |
| Becherucci, C; Parente, L; Perretti, M; Scapigliati, G | 1 |
| Payne, AN; Yeadon, M | 1 |
| Abraham, NG; Lutton, JD; Schwartzman, ML | 1 |
| Fitzgerald, MF; Parente, L; Whittle, BJ | 1 |
| Hillier, K; Jones, DB; Pacheco, S | 1 |
| Farnam, J; Giclas, PC; Grant, JA; Hunt, C; Lett-Brown, MA; Thueson, DO | 1 |
| de Wildt, DJ; Nijkamp, FP; van Heuven-Nolsen, D | 1 |
| Boctor, AM; Burke, C; Hovinga, ME | 1 |
| Brooks, PM; Forrest, MJ; Zammit, V | 1 |
| Adkinson, NF; Gottlieb, JE; McGeady, M; Sylvester, JT | 1 |
| Gordon, T; Sheppard, D; Thompson, JE | 1 |
| Hartung, HP; Heininger, K; Schäfer, B; Stoll, G; Toyka, KV | 1 |
| Lefkowith, JB; Morrison, AR; Schreiner, GF | 1 |
| Aursudkij, B; Barnes, PJ; Chung, KF; Evans, TW; Rogers, DF | 1 |
| Canonico, PL; Cronin, MJ; MacLeod, RM; Scapagnini, U; Sortino, MA; Speciale, C | 1 |
| Amezcua, JL; Mourelle, M; Pérez-Alvarez, V | 1 |
| Churchill, L; Ward, PE | 1 |
| Canonico, PL; Judd, AM; Koike, K; MacLeod, RM; Valdenegro, CA | 1 |
| Kato, R; Nakadate, T; Uzumaki, H; Yamamoto, S | 1 |
| Jondal, M; Kullman, C; Lindgren, JA; Rossi, P | 1 |
| Demharter, R; Gärtner, R; Greil, W; Horn, K | 1 |
| Conn, PJ; Sanders-Bush, E | 1 |
| Aked, D; Foster, SJ; Howarth, A; McCormick, ME | 1 |
| Maridonneau-Parini, I; Tauber, AI; Tringale, SM | 1 |
| Boctor, AM; Eickholt, M; Pugsley, TA | 1 |
| Roth, JA; Webb, DS | 1 |
| Beck, G; Denzlinger, C; Hammer, DK; Keppler, D; Scheuber, PH; Wilker, D | 1 |
| Hand, JM; Lewis, AJ; Schwalm, SF | 1 |
| Abraham, NG; Mullane, KM; Pinto, A | 1 |
| Kato, R; Uzumaki, H; Yamamoto, S | 1 |
| Cacini, AT; Cunha, FQ; Ferreira, SH | 1 |
| Lapetina, EG; Moncada, S; Read, NG; Reep, B | 1 |
| Desforges, JF; Snyder, DS | 1 |
| Goto, S; Inagaki, N; Koda, A; Nagai, H; Yamasaki, M | 1 |
| Altman, R; Scazziota, A | 1 |
| Miller, AM; Weiner, RS; Ziboh, VA | 1 |
| Eynard, A; Galli, G; Gregori, M; Maderna, P; Tremoli, E | 1 |
| Boukili, MA; Bureau, M; Lagente, V; Lefort, J; Lellouch-Tubiana, A; Malanchère, E; Vargaftig, BB | 1 |
| De Nucci, G; Moncada, S; Salmon, JA | 1 |
| Dunkel, CG; Evers, AS; Needleman, P; Saffitz, JE | 1 |
| Murlas, CG; Thorpe, JE | 1 |
| Lahti, A; Maibach, HI; McDonald, DM; Tammi, R | 1 |
| Chan, KM; Turk, J | 1 |
| Kishore, NP; Rao, GH; White, JG | 1 |
| Chaudhuri, G; Hayden, B; Soderberg, R; Zarem, H | 1 |
| Bennett, A; Capasso, F; Rennie, JA; Tavares, IA; Tsang, R | 1 |
| Barnes, PJ; Chung, KF; Evans, TW; Rogers, DF | 1 |
| Bertrand, C; Frossard, N; Landry, Y; Tschirhart, E | 1 |
| Mantovani, M; Valenti, F; Villa, ML | 1 |
| Abbate, M; Bertani, T; Cucchi, M; Delaini, F; Perico, N; Remuzzi, G; Tagliaferri, M | 1 |
| Capdevila, JH; Falck, JR; Kaminski, PM; Proctor, KG; Shatkin, S | 1 |
| Fleisher, LN | 1 |
| Barton, BE; Wheeler, L; WoldeMussie, E | 1 |
| Montaño, LM; Páramo, JI; Selman, ME; Vargas, MH | 1 |
| Acker, G; Braquet, P; Etienne, A; Hecquet, F; Mencia-Huerta, JM | 1 |
| Anderson, CB; Brunt, E; Jendrisak, MD; Mangino, MJ | 1 |
| Goldin, E; Harel, S; Magal, E; Yavin, E | 1 |
| Béliard, R; Bocquet, J; Bouakka, M; Jouis, V; Langris, M; Legendre, P; Loyau, G | 1 |
| Easom, RA; Hughes, JH; Lacy, PE; McDaniel, ML; Scharp, DW; Turk, J; Wolf, BA | 1 |
| Fiera, RA; Matthews, N; Neale, ML | 1 |
| Peers, SH | 1 |
| Anderson, GP; Fennessy, MR; White, HL | 1 |
| Guth, PH; Wayland, H; Yonei, Y | 1 |
| Mahadevappa, VG; Vedelago, HR | 1 |
| Hiley, CR; Kay, AP; Randall, MD | 1 |
| Brooks, RR; Doerr, IL; Kaufman, J | 1 |
| Baum, T; Pula, K; Rivelli, M; Sybertz, EJ; Watkins, RW | 1 |
| Carbonell, L; Parellada, PP | 1 |
| Kojima, I; Kojima, K; Rasmussen, H | 1 |
| Boeynaems, JM; Galand, N; Ketelbant, P | 1 |
| Burka, JF | 1 |
| Brune, K; Peskar, BA | 1 |
| Wallace, JL; Whittle, BJ | 1 |
| Falkay, G; Pacsa, AS; Szekeres-Bartho, J; Török, A | 1 |
| Boughton-Smith, NK; Whittle, BJ | 1 |
| Hidaka, T; Hosoe, K; Katsumi, I; Takeo, K; Watanabe, K; Yamashita, T | 1 |
| Lee, HK; Murlas, C | 1 |
| Allix, M; Boulu, RG; Capdeville, C; el Bouchi, N; Fradin, A; Plotkine, M; Russo-Marie, F | 1 |
| Austen, KF; Schick, B | 1 |
| Cooke, BA; Sullivan, MH | 1 |
| Bird, J; Giroud, JP; Tissot, M | 1 |
| Johnson, KJ; Sulavik, MC; Ward, PA | 1 |
| Colotta, F; de Gaetano, G; Semeraro, N; Villa, S | 1 |
| Knepel, W; Vlaskovska, M | 1 |
| Denzlinger, C; Hagmann, W; Keppler, D | 1 |
| Boot, JR; Cox, B; Dawson, W; Walker, JR | 1 |
| Moncada, S; Salmon, JA; Simmons, PM | 1 |
| Andersson, RG; Norrby, K | 1 |
| Bax, CM; Higgs, GA; Moncada, S | 1 |
| Higgs, GA; Mugridge, KG | 1 |
| Corzo, J; Fremont-Smith, M; Guarner, F; Prieto, J; Quiroga, J; Rodriguez, JL | 1 |
| Formelli, F; Mazzoni, A; Supino, R | 1 |
| Palmer, RM; Salmon, JA; Simmons, PM | 1 |
| Higgs, GA; Moncada, S; Mugridge, KG; Vane, JR | 1 |
| Clanton, JA; Colley, DG; Rand, TH | 1 |
| Bhattacherjee, P; Eakins, KE; Williams, RN | 1 |
| Appleby, BJ; Buck, DC; Casey, FB | 1 |
| Harvey, J; Osborne, DJ | 1 |
| Johnson, EA; Schwender, CF; Sircar, JC | 1 |
| Mitchell, HW | 5 |
| Bonney, RJ; Galavage, M; Goldenberg, M; Humes, JL; Kuehl, FA; Sadowski, S; Subers, E | 1 |
| Easmon, CS; Higgs, GA; Plant, JE | 1 |
| Bizios, R; Malik, AB; Minnear, FL; van der Zee, H | 1 |
| Boughton-Smith, NK; Hawkey, CJ; Whittle, BJ | 1 |
| Moncada, S; Mullane, KM; Read, N; Salmon, JA | 1 |
| Goossens, J; Van Wauwe, J | 1 |
| Borgeat, P; Braquet, P; Salari, H | 1 |
| Canonico, PL; Judd, AM; MacLeod, RM; Valdenegro, CA | 1 |
| Bridén, S; Flemström, G; Kivilaakso, E | 1 |
| Bergman, A; Bridén, S; Flemström, G | 1 |
| Cooke, BA; Dix, CJ; Habberfield, AD; Sullivan, MH | 1 |
| Chang, J; Cherney, ML; Lewis, AJ; Skowronek, MD | 1 |
| Cohen, MM; Wallace, JL | 1 |
| Seaman, WE; Woodcock, J | 1 |
| Adams, T; Manley, G; Steiner, S | 1 |
| Holsapple, MP; Yim, GK | 1 |
| Mallarkey, G; Smith, GM | 1 |
| Caen, JP; Hardisty, R; Levy-Toledano, S; Maclouf, J; Savariau, E | 1 |
| Barth, T; Bekemeier, H; Hänsel, F; Hirschelmann, R; Sänze, JU | 1 |
| Eakins, KE; Higgs, GA; Randall, RW; Salmon, JA; Tateson, JE | 2 |
| Mikami, T; Miyasaka, K | 1 |
| Moncada, S; Mullane, KM | 1 |
| Ishii, M; Kato, R; Nakadate, T; Yamamoto, S | 1 |
| Johns, E; Michael, J; Richards, NT; Wu, XC | 2 |
| Adachi, T; Nakamura, T; Nakashima, S; Nozawa, Y; Saji, S | 1 |
| Hales, CA; Hutchison, WG; Mahoney, E; Musto, S | 1 |
| de Witte, P; Geboes, K; Lemli, J; Meulemans, A; Nijs, G; Schuurkes, J | 2 |
| Cordeiro, RS; Vargaftig, BB; Zuany-Amorim, C | 1 |
| Ho, TF; Lin, CN; Teng, CM; Wang, JP | 1 |
| Hales, CA; Hutchison, WG; Janssens, SP; Jung, W; Musto, SW; Spence, C; Witten, M | 1 |
| Arnould, T; De Leener, F; Dieu, M; Michiels, C; Remacle, J | 1 |
| Baran, H; Hornykiewicz, O; Lassmann, H; Vass, K | 1 |
| Bell-Quilley, CP; Drugge, ED; Hilchey, SD; Lin, YS; McGiff, JC | 1 |
| Colombo, C; DiPasquale, G; Fryer, LR; Greenspan, PD; Haston, W; Healy, C; Kotyuk, B; Pastor, G; Pellas, TC; Raychaudhuri, A | 1 |
| Flotte, T; Gange, RW; Kochevar, IE; Lyon, N; Moran, M; Siebert, E | 1 |
| Arnould, T; Dieu, M; Knott, I; Michiels, C; Remacle, J | 1 |
| Arena, S; Dolan, RW; Kerr, D | 1 |
| Campbell, WB; Pfister, SL | 1 |
| Desouza, IA; Ribeiro-DaSilva, G | 1 |
| Harnack, E; Racke, K; Reinheimer, T; Wessler, I | 1 |
| Geertsma, MF; Nibbering, PH; Van Den Barselaar, MT; Van Furth, R; Zheng, L; Zomerdijk, TP | 1 |
| Desouza, IA; Franco-Penteado, CF; Hyslop, S; Ribeiro-DaSilva, G | 2 |
| Dasgupta, SC; Gomes, A; Karmakar, S; Muhuri, DC; Nagchaudhuri, AK | 1 |
| Dasgupta, SC; Gomes, A; Muhuri, D | 1 |
| Aggarwal, NT; Campbell, WB; Gauthier, KM | 1 |
206 other study(ies) available for bw-755c and indomethacin
| Article | Year |
|---|---|
Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acids; Butadienes; Chemical Phenomena; Chemistry; Lipoxygenase Inhibitors; Male; Mice; Structure-Activity Relationship; Sulfhydryl Compounds | 1990 |
Antiinflammatory 2,6-di-tert-butyl-4-(2-arylethenyl)phenols.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Edema; Lipoxygenase Inhibitors; Male; Phenols; Rats; Structure-Activity Relationship; Styrenes | 1989 |
5-Acyl-3-substituted-benzofuran-2(3H)-ones as potential antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arthritis; Arthritis, Experimental; Benzofurans; Female; Guinea Pigs; Lipoxygenase; Neutrophils; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1987 |
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.
Topics: Animals; Antioxidants; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Line, Transformed; Cell Nucleus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Indicators and Reagents; Isoenzymes; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Malondialdehyde; Membrane Proteins; Models, Molecular; Molecular Conformation; Molecular Structure; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship | 1998 |
Pharmacological modulation of the endotoxin-induced increase in plasminogen activator inhibitor activity in rats.
Topics: 1-Methyl-3-isobutylxanthine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Aspirin; Dose-Response Relationship, Drug; Enzyme Activation; Indomethacin; Lipopolysaccharides; Male; Plasminogen Activator Inhibitor 1; Rats; Rats, Wistar; Tissue Plasminogen Activator | 1992 |
Opsonized zymosan decreases cytoplasmic motility of alveolar macrophages in dogs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Aminopeptidases; Animals; Calcium; Captopril; Cells, Cultured; Cytoplasm; Dogs; Indomethacin; Leucine; Leupeptins; Macrophages; Phagocytosis; Pulmonary Alveoli; Superoxide Dismutase; Zymosan | 1992 |
Kinetics of photoperoxidation of arachidonic acid: molecular mechanisms and effects of antioxidants.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Antioxidants; Arachidonic Acid; beta Carotene; Carotenoids; Free Radicals; Indomethacin; Kinetics; Oxidation-Reduction; Peroxides; Photochemistry; Photosensitizing Agents; Probucol; Vitamin E | 1992 |
Endotoxin stimulation of liver parenchymal cell phosphofructokinase activity requires nonparenchymal cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bacterial Toxins; Carbohydrate Metabolism; Cycloheximide; Cytokines; Dexamethasone; Endotoxins; Enterotoxins; Glucose; Indomethacin; Liver; Male; Phosphofructokinase-1; Rats; Rats, Inbred Strains; Salmonella | 1992 |
Prostaglandin profile and synthetic capacity of the colon: comparison of tissue sources and subcellular fractions.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Caffeic Acids; Colon; Cytosol; Dinoprostone; Epoprostenol; Indomethacin; Intestinal Mucosa; Male; Microsomes; Muscle, Smooth; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred Strains | 1992 |
Ionic, electrical, and secretory effects of inhibitors of arachidonic acid metabolism in mouse pancreatic beta-cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Aspirin; Calcium; Cell Membrane Permeability; Cells, Cultured; Cyclooxygenase Inhibitors; Electric Conductivity; Female; Glucose; Hydrogen-Ion Concentration; Ibuprofen; Indomethacin; Insulin; Islets of Langerhans; Lipoxygenase Inhibitors; Membrane Potentials; Mice; Microelectrodes; Potassium; Potassium Channels; Radioimmunoassay; Rubidium Radioisotopes; Sodium Salicylate | 1992 |
Contributions of arachidonic acid derivatives and substance P to the sensitization of cutaneous nociceptors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Dipyrone; Ear; In Vitro Techniques; Indomethacin; Nociceptors; Perfusion; Rabbits; Skin; Substance P; Temperature | 1990 |
Comparison of the effects of intra-arterial and aerosol administration of endothelin-1 (ET-1) in the guinea-pig isolated lung.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Aerosols; Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Endothelins; Guinea Pigs; Histamine Release; In Vitro Techniques; Indomethacin; Injections, Intra-Arterial; Lung; Male; Masoprocol; Perfusion; Respiratory Function Tests; SRS-A; Thromboxane A2 | 1991 |
Characterization of bradykinin receptors in peripheral organs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bradykinin; Cricetinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Jugular Veins; Leukotriene Antagonists; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin A; Polyphloretin Phosphate; Prostaglandin Antagonists; Quinolines; Rabbits; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Substance P; Trachea; Urinary Bladder | 1991 |
Arachidonic acid metabolism in cultured astrocytes: presence of 12-lipoxygenase activity in the intact cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Astrocytes; Calcimycin; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Hydroxyeicosatetraenoic Acids; Indomethacin; Pregnancy; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1991 |
Role of prostaglandins and leukotrienes in the synergistic effect of oxytocin and corticotropin-releasing hormone (CRH) on the contraction force in human gestational myometrium.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Benzeneacetamides; Corticotropin-Releasing Hormone; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Hydroxamic Acids; Indomethacin; Leukotrienes; Lipoxygenase Inhibitors; Myometrium; Oxytocin; Pregnancy; Uterine Contraction | 1991 |
Murine thymocyte lysis by inhibitors of arachidonic acid metabolism.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adrenal Cortex Hormones; Animals; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Caffeic Acids; Cells, Cultured; Dexamethasone; Dinoprostone; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Mice; Mice, Inbred C57BL; Spleen; Thymus Gland | 1991 |
Role of arachidonic acid metabolites in the pathogenesis of acute lung injury.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Diethylcarbamazine; Disease Models, Animal; Dogs; Ethchlorvynol; Indomethacin; Leukotrienes; Lung; Male; Methacrylates; Neutrophils; Pulmonary Edema; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Thromboxanes | 1991 |
Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adrenocorticotropic Hormone; Animals; Benzeneacetamides; Corticotropin-Releasing Hormone; Cytokines; Eicosanoids; Hydroxamic Acids; Hypothalamus; In Vitro Techniques; Indomethacin; Interleukin-1; Interleukin-6; Kinetics; Lipoxygenase Inhibitors; Male; Naproxen; Pituitary Gland; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Recombinant Proteins | 1991 |
The role of leukotriene B4 in neutrophil infiltration in experimentally-induced inflammation of rat tooth pulp.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cell Movement; Cyclophosphamide; Dental Pulp; Indomethacin; Leukocyte Count; Leukotriene B4; Lipopolysaccharides; Male; Neutrophils; Pulpitis; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acids; Carbon Radioisotopes; Cholesterol, Dietary; Clotrimazole; Diet, Atherogenic; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Kinetics; Masoprocol; Metyrapone; Muscle, Smooth, Vascular; Rabbits; Reference Values; Stereoisomerism | 1991 |
Possible implication of arachidonic acid metabolism in the decrease of chemiluminescence production after exposure of murine peritoneal macrophages to diethylnitrosamine and tumour promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cell Survival; Culture Media; Cyclooxygenase Inhibitors; Diethylnitrosamine; Dose-Response Relationship, Drug; Extracellular Space; Female; Indomethacin; Intracellular Fluid; Isoquinolines; Kinetics; Leukotrienes; Luminescent Measurements; Macrophage Activation; Macrophages; Mice; Oxygen; Peritoneal Cavity; Phospholipids; Piperazines; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Cytochrome P-450-dependent vasodilator responses to arachidonic acid in the isolated, perfused kidney of the rat.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Clotrimazole; Cytochrome P-450 Enzyme System; In Vitro Techniques; Indomethacin; Kidney; Male; Oxazines; Phenylephrine; Rats; Rats, Inbred Strains; Renal Circulation; Sulfonamides; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Tumor necrosis factor-alpha increases release of arachidonate and prolactin from rat anterior pituitary cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Culture Media; Female; Indomethacin; Melitten; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Tumor Necrosis Factor-alpha | 1991 |
Extract and compounds obtained from Mandevilla velutina inhibit arachidonic acid-induced ear oedema in mice, but not rat stomach contraction.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Edema; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Lipoxygenase Inhibitors; Male; Masoprocol; Mice; Muscle, Smooth; Plant Extracts; Pyrazoles; Rats; Stomach | 1991 |
Evidence against a role of arachidonic acid metabolites in autoregulatory responses of the isolated perfused kidney of the rat.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Diabetes Mellitus, Experimental; Dinoprostone; In Vitro Techniques; Indomethacin; Kidney; Male; Nifedipine; Perfusion; Rats; Rats, Inbred Strains; Renal Circulation; Vascular Resistance | 1991 |
Evidence that interleukin-1 and lipoxygenase metabolites mediate the lethal effect of complete Freund's adjuvant in adrenalectomized rats.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adjuvants, Immunologic; Adrenalectomy; Animals; Aspirin; Dexamethasone; Indomethacin; Interleukin-1; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Peritoneal Cavity; Rats; Rats, Inbred Strains; Recombinant Proteins | 1991 |
Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 17-alpha-Hydroxyprogesterone; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstenedione; Androstenols; Animals; Chorionic Gonadotropin; Estradiol; Female; Hydroxyeicosatetraenoic Acids; Hydroxyprogesterones; Indomethacin; Masoprocol; Ovulation; Ovulation Induction; Progesterone; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Steroids; Testosterone | 1991 |
Pharmacological characterization of polycation-induced rat hind-paw oedema.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arginine; Azepines; Dexamethasone; Edema; Evans Blue; Heparin; Histamine; Indomethacin; Male; omega-N-Methylarginine; Peptides; Polylysine; Rats; Rats, Inbred Strains; Serotonin; Triazoles | 1990 |
Capillary permeability factor secreted by malignant brain tumor. Role in peritumoral brain edema and possible mechanism for anti-edema effect of glucocorticoids.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Autoradiography; Brain Edema; Brain Neoplasms; Capillary Permeability; Carcinosarcoma; Dexamethasone; Glioma; Humans; Indomethacin; Male; Neoplasm Proteins; Rats; Rats, Inbred Strains; Tumor Cells, Cultured | 1990 |
Relationships between tumour necrosis factor, eicosanoids and platelet-activating factor as mediators of endotoxin-induced shock in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Capillary Permeability; Diterpenes; Drug Interactions; Eicosanoids; Endotoxins; Escherichia coli; Female; Ginkgolides; Hematocrit; Indomethacin; Lactones; Mice; Platelet Activating Factor; Recombinant Proteins; Shock, Septic; Tumor Necrosis Factor-alpha | 1990 |
Fatty acids and cyclooxygenase and lipoxygenase pathway inhibitors modulate inositol phosphate formation in pancreatic islets.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Carbachol; Dinoprostone; Glucose; Ibuprofen; Indomethacin; Inositol Phosphates; Islets of Langerhans; Lipoxygenase; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains | 1990 |
Cyclooxygenase inhibitors increase canine tracheal muscle response to parasympathetic stimuli in situ.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cyclooxygenase Inhibitors; Dogs; Electric Stimulation; Female; Indomethacin; Lipoxygenase Inhibitors; Male; Meclofenamic Acid; Parasympathetic Nervous System; Respiratory Muscles; Trachea; Vagus Nerve | 1990 |
Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Diclofenac; Edema; Elapid Venoms; Female; Gastric Mucosa; Indomethacin; Isoindoles; Levamisole; Male; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium | 1990 |
Evidence for the presence of a new plasma factor which acts synergistically to ADP induced platelet aggregation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine Diphosphate; Animals; Biological Factors; Cimetidine; Drug Synergism; Enzymes; Epoprostenol; Heparin; Indomethacin; Ketanserin; Macaca mulatta; Male; Masoprocol; Mice; Mice, Inbred Strains; Phentolamine; Platelet Aggregation | 1990 |
Effects of anti-inflammatory and immunosuppressive drugs on the heterolamellar corneal transplantation in rabbits.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Administration, Topical; Animals; Anti-Inflammatory Agents; Aqueous Humor; Arachidonic Acid; Arachidonic Acids; Cattle; Cell Count; Corneal Transplantation; Cyclosporins; Dexamethasone; Eye Proteins; Graft Rejection; Immunosuppressive Agents; Indomethacin; Inflammation; Neutrophils; Rabbits; Transplantation, Heterologous | 1990 |
Nimesulide, indomethacin, BW 755 C, phenidon, mepacrin and nedocromil inhibit the activation of human and rat leucocytes.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; In Vitro Techniques; Indomethacin; Leukocytes; Lipoxygenase Inhibitors; Luminescent Measurements; Nedocromil; Phospholipases A; Pyrazoles; Quinacrine; Quinolones; Rats; Sulfonamides | 1990 |
Endothelin modulation of neuroeffector transmission in rat and guinea pig vas deferens.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine Triphosphate; Animals; Autonomic Nervous System; Colforsin; Electric Stimulation; Endothelins; Felodipine; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Neuroeffector Junction; Norepinephrine; Rats; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens | 1990 |
Differential inhibition of histamine release from human basophils induced by antigen, anti-IgE or N-formyl-L-methionyl-L-leucyl-L-phenylalanine.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Antibodies, Anti-Idiotypic; Antigens; Basophils; Catechols; Cells, Cultured; Chromones; Histamine Release; Humans; Immunoglobulin E; Indoles; Indomethacin; Masoprocol; Meclofenamic Acid; N-Formylmethionine Leucyl-Phenylalanine; Oxazoles; Pyrazoles; Receptors, Fc; Receptors, Formyl Peptide; Receptors, IgE; Receptors, Immunologic; Tetrazoles | 1985 |
Modulation of substance P-induced bronchoconstriction by lipoxygenase metabolites.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Airway Resistance; Anesthesia; Animals; Anti-Inflammatory Agents; Aspirin; Bronchi; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipoxygenase; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Substance P | 1985 |
The effect of indomethacin on anaphylactic contraction and histamine release in guinea-pig lung parenchymal strips.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anaphylaxis; Animals; Chromones; Female; Guinea Pigs; Histamine Release; In Vitro Techniques; Indomethacin; Lung; Muscle Contraction; Muscle, Smooth; Ovalbumin; Pyrazoles; SRS-A | 1986 |
Effect of CI-922, a potential new antiallergy agent, on arachidonic acid metabolism in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adult; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Azoles; Calcimycin; Cattle; Histamine Release; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indoles; Indomethacin; Leukocytes; Male; Masoprocol; Pyrazoles; Seminal Vesicles; Tetrazoles | 1986 |
Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Blood-Brain Barrier; Capillaries; Capillary Permeability; Cats; Cerebral Arteries; Cerebral Veins; Cerebrovascular Circulation; Dextrans; Female; Fluorescein-5-isothiocyanate; Fluoresceins; Indomethacin; Male; Microscopy, Electron; Pyrazoles; Thiocyanates; Vasomotor System | 1987 |
Chemical factors in the sensitization of cutaneous nociceptors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bradykinin; Indomethacin; Nociceptors; Prostaglandins E; Pyrazoles; Rabbits; Skin; Substance P | 1988 |
Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adrenalectomy; Animals; Annexins; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Dexamethasone; Dextrans; Edema; Glycoproteins; Indomethacin; Male; Methotrexate; p-Methoxy-N-methylphenethylamine; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pyrazoles; Rats; Rats, Inbred Strains; Recombinant Proteins; Serotonin | 1989 |
Pharmacological investigation of acute cellular accumulation in immunological air pouch inflammation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antigens; Aprotinin; Bromelains; Cimetidine; Colchicine; Cromolyn Sodium; Cyproheptadine; Elapid Venoms; Immune Sera; Indomethacin; Inflammation; Leukocytes; Male; Neutrophils; Prednisolone; Pyrazoles; Rats; T-Lymphocytes | 1989 |
Adherence of leucocytes to electrically damaged venules in vivo. Effects of iloprost, PGE1, indomethacin, forskolin, BW 755 C, sulotroban, hirudin, and thrombocytopenia.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alprostadil; Animals; Cell Adhesion; Colforsin; Electric Stimulation; Epoprostenol; Hirudins; Iloprost; Indomethacin; Leukocytes; Male; Mesenteric Veins; Rats; Rats, Inbred Strains; Sulfonamides; Thrombocytopenia; Venules | 1988 |
Role of arachidonic acid metabolites in acid-pepsin injury to rabbit esophagus.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Esophagitis; Esophagus; Hydrogen-Ion Concentration; Indomethacin; Male; Pepsin A; Premedication; Pyrazoles; Rabbits; Sodium Chloride | 1989 |
Lipoxygenase inhibitors enhance the proliferation of human B cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adjuvants, Immunologic; Adult; B-Lymphocytes; Benzoquinones; Cell Differentiation; Child; Cyclooxygenase Inhibitors; Dose-Response Relationship, Immunologic; Humans; Immunoglobulins; Indomethacin; Interleukin-4; Interleukins; Kinetics; Lipoxygenase Inhibitors; Lymphocyte Activation; Masoprocol; Palatine Tonsil; Pyrazoles; Quinones; Staphylococcal Protein A | 1989 |
Relationship between PAF-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Escherichia coli; Ethanol; Imidazoles; Indomethacin; Jejunum; Lipopolysaccharides; Male; Methacrylates; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Strains; Shock, Septic; Thromboxane A2; Thromboxane-A Synthase | 1989 |
Alveolar macrophages and eicosanoids but not neutrophils, mediate bronchoconstriction induced by FMLP in the guinea-pig.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Aerosols; Animals; Aspirin; Bronchi; Cyclooxygenase Inhibitors; Eicosanoids; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipoxygenase; Macrophages; Male; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pulmonary Alveoli; Trachea; Vinblastine | 1989 |
Increased microvascular permeability caused by toxic oxygen metabolites is partly reversed by exchanging the perfusate in isolated rat lungs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Capillary Permeability; Catalase; Hypoxanthines; In Vitro Techniques; Indomethacin; Lung; Male; Oxygen; Papaverine; Perfusion; Rats; Rats, Inbred Strains; Xanthine Oxidase | 1989 |
Blockade of ADP-induced Ca2+-signal and platelet aggregation by lipoxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Calcium; Humans; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Platelet Aggregation; Platelet Aggregation Inhibitors; Signal Transduction | 1989 |
Contraction followed by relaxation in response to hypoxia in the sheep isolated middle cerebral artery.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cerebral Arteries; Endothelium; Hypoxia; Indomethacin; Methylene Blue; Muscle Contraction; Muscle Relaxation; Quinacrine; Serotonin; Sheep | 1989 |
The effect of adrenalectomy on interleukin-1 release in vitro and in vivo.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adrenalectomy; Animals; Cells, Cultured; Dexamethasone; Dinoprostone; Freund's Adjuvant; Humans; In Vitro Techniques; Indomethacin; Interleukin-1; Lipopolysaccharides; Macrophages; Precipitin Tests; Rats; Rats, Inbred Strains | 1989 |
Ascorbic acid prevents ozone-induced bronchial hyperreactivity in guinea-pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Ascorbic Acid; Bronchi; Guinea Pigs; In Vitro Techniques; Indomethacin; Ozone | 1989 |
Cytochrome P450 dependent arachidonic acid metabolism in hemopoietic cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythropoiesis; Hematopoietic Stem Cells; Humans; Indomethacin; Lipoxygenase Inhibitors; Mice; NADP; Neutrophils; Pyridines | 1989 |
Release of PAF-acether and eicosanoids from guinea-pig alveolar macrophages by FMLP: effect of cyclo-oxygenase and lipoxygenase inhibition.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Benzeneacetamides; Cyclooxygenase Inhibitors; Guinea Pigs; Hydroxamic Acids; In Vitro Techniques; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pulmonary Alveoli; Pyrazoles; Radioimmunoassay; Thromboxane B2 | 1989 |
The effect of sulphasalazine on the in vitro activation of human peripheral blood mononuclear cells by phytohemagglutinin P.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Dinoprostone; Humans; In Vitro Techniques; Indomethacin; Inflammatory Bowel Diseases; Leukocytes, Mononuclear; Phytohemagglutinins; Sulfasalazine | 1989 |
Complement- and IgE-mediated release of histamine from basophils in vitro. V. Differential effects of drugs modulating arachidonic acid metabolism.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Basophils; Catechols; Complement C5; Complement C5a; Histamine Release; Humans; Immunoglobulin E; Indomethacin; Masoprocol; Phospholipases; Pyrazoles | 1985 |
Cyclo-oxygenase products mediate down regulation of beta 2-adrenoceptor function in the guinea pig coronary vascular system by endotoxin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Albuterol; Animals; Cardiovascular System; Guinea Pigs; Indomethacin; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Receptors, Adrenergic, beta; Virulence Factors, Bordetella | 1987 |
Arachidonic acid-induced pleurisy (ARIP): an in vivo model for testing 5-lipoxygenase inhibition.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; Arachidonic Acids; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pleurisy; Prostaglandins E; Pyrazoles; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Inhibition of leucotriene B4 synthesis by BW 755c does not reduce polymorphonuclear leucocyte (PMNL) accumulation induced by monosodium urate crystals.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Indomethacin; Inflammation; Leukocyte Count; Leukotriene B4; Male; Neutrophils; Prostaglandins E; Prostaglandins E, Synthetic; Pyrazoles; Rats; Rats, Inbred Strains; Uric Acid | 1988 |
Effects of cyclo- and lipoxygenase inhibitors on hypoxic vasoconstriction in isolated ferret lungs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Gas Analysis; Blood Pressure; Catechols; Cyclooxygenase Inhibitors; Dinoprost; Ferrets; Hydrogen-Ion Concentration; Hypoxia; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Organ Culture Techniques; Oxygen; Potassium Chloride; Prostaglandins F; Pyrazoles; Vasoconstriction | 1988 |
Arachidonic acid metabolites do not mediate toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetylcholine; Airway Obstruction; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dogs; Drug Synergism; Epoprostenol; Guinea Pigs; Indomethacin; Male; Ozone; Pyrazoles; Respiratory System; Toluene 2,4-Diisocyanate | 1988 |
The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis. Serial clinical, electrophysiological, biochemical and morphological observations.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dexamethasone; Female; Indomethacin; Lipoxygenase Inhibitors; Macrophages; Neuritis, Autoimmune, Experimental; Pyrazoles; Rats; Rats, Inbred Lew; Silicon Dioxide | 1988 |
Murine glomerular leukotriene B4 synthesis. Manipulation by (n-6) fatty acid deprivation and cellular origin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Calcimycin; Chromatography, High Pressure Liquid; Dinoprostone; Dose-Response Relationship, Drug; Fatty Acids; Indomethacin; Kidney Glomerulus; Leukotriene B4; Mice; Pyrazoles; Radioimmunoassay; Rats; Rats, Inbred Lew | 1988 |
Inflammatory mediators involved in antigen-induced airway microvascular leakage in guinea pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antigens; Bronchi; Capillary Permeability; Chlorpheniramine; Chromones; Cimetidine; Guinea Pigs; Immunization; Indomethacin; Inflammation; Lactones; Larynx; Male; Nasal Mucosa; Nedocromil; Ovalbumin; Plant Extracts; Pyrazoles; Quinolones; Respiratory System; Trachea; Urinary Bladder | 1988 |
Growth hormone releasing factor (GRF) increases free arachidonate levels in the pituitary: a role for lipoxygenase products.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Growth Hormone-Releasing Hormone; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Male; Peptide Fragments; Pituitary Gland; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Somatostatin | 1986 |
Reduction of apparent indicators of liver cirrhosis in rats by the arachidonate lipoxygenase inhibitor BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Carbon Tetrachloride Poisoning; Cell Membrane; Colchicine; Collagen; gamma-Glutamyltransferase; Indomethacin; Liver Cirrhosis, Experimental; Male; Pyrazoles; Rats; Rats, Inbred Strains | 1987 |
Conversion of B1 kinin receptor-mediated vascular relaxation to contraction.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bradykinin; Dose-Response Relationship, Drug; Indomethacin; Kallidin; Male; Pyrazoles; Rabbits; Receptors, Bradykinin; Receptors, Neurotransmitter; Vasoconstriction; Vasodilation | 1987 |
Arachidonate stimulates prolactin release in vitro: a role for the fatty acid and its metabolites as intracellular regulator(s) in mammotrophs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Bucladesine; Catechols; Cells, Cultured; Female; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Oleic Acid; Oleic Acids; Phospholipases A; Phospholipases A2; Pituitary Gland; Pituitary Gland, Anterior; Prolactin; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Stearic Acids; Tetradecanoylphorbol Acetate | 1985 |
Lipoxygenase inhibitors and cyclic AMP-mediated insulin secretion caused by forskolin, theophylline and dibutyryl cyclic AMP.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bucladesine; Catechols; Colforsin; Cyclic AMP; Diterpenes; Indomethacin; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Lipoxygenase Inhibitors; Male; Masoprocol; Pyrazoles; Rats; Secretory Rate; Theophylline | 1985 |
Second messenger function of arachidonic acid lipoxygenation products in human natural killer cell lysis?
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Catechols; Cyclic AMP; Cyclic GMP; Cytotoxicity, Immunologic; Humans; Indomethacin; Killer Cells, Natural; Lipoxygenase; Masoprocol; Pyrazoles | 1985 |
Involvement of cyclic AMP, iodide and metabolites of arachidonic acid in the regulation of cell proliferation of isolated porcine thyroid follicles.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Catechols; Cell Division; Colforsin; Culture Media; Culture Techniques; Cyclic AMP; Deoxyadenosines; Dideoxyadenosine; Epidermal Growth Factor; Indomethacin; Insulin; Iodides; Masoprocol; Propylthiouracil; Pyrazoles; Swine; Thyroid Gland; Thyrotropin | 1985 |
Biochemical characterization of serotonin stimulated phosphoinositide turnover.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Cerebral Cortex; Drug Synergism; Indomethacin; Phosphatidylinositols; Potassium Chloride; Protease Inhibitors; Pyrazoles; Rats; Serotonin; Tetrodotoxin; Veratrine | 1986 |
Leukocyte recruitment in the subcutaneous sponge implant model of acute inflammation in the rat is not mediated by leukotriene B1.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acute Disease; Animals; Blood Proteins; Calcimycin; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Indomethacin; Inflammation; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Prostaglandins E; Pyrazoles; Pyrazolones; Rats; Rats, Inbred Strains; Skin | 1986 |
Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Enzyme Activation; Humans; Indomethacin; Isoquinolines; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Piperazines; Pyrazoles; Quinacrine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; Arachidonic Acids; Cattle; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Meclofenamic Acid; ortho-Aminobenzoates; Prostaglandins E; Pyrazoles; Seminal Vesicles | 1986 |
Relationship of glucocorticoid suppression of arachidonic acid metabolism to alteration of neutrophil function.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Cattle; Dexamethasone; Diglycerides; Hydroxyeicosatetraenoic Acids; Indomethacin; Leukotriene B4; Masoprocol; Neutrophils; Phospholipids; Pyrazoles; Triglycerides; Zymosan | 1987 |
Staphylococcal enterotoxin B as a nonimmunological mast cell stimulus in primates: the role of endogenous cysteinyl leukotrienes.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Animals; Enterotoxins; Haplorhini; Indomethacin; Mast Cells; Pyrazoles; Receptors, Leukotriene; Receptors, Prostaglandin; Skin Tests; SRS-A; Tetrazoles; Vomiting | 1987 |
Antagonism of antigen-induced contraction of isolated guinea-pig trachea by 5-lipoxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonate Lipoxygenases; Catechols; Chlorpheniramine; Guinea Pigs; Hypersensitivity; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Pyrazoles; SRS-A; Trachea | 1986 |
Cytochrome P-450-dependent monooxygenase activity and endothelial-dependent relaxations induced by arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Benzoflavones; beta-Naphthoflavone; Blood Vessels; Cobalt; Cytochrome P-450 Enzyme System; Drug Synergism; Endothelium; Fatty Acids; Indomethacin; Male; Methylcholanthrene; Oxygenases; Phenylephrine; Proadifen; Pulmonary Artery; Pyrazoles; Rabbits; Vasoconstriction; Vasodilation | 1986 |
Effects of lipoxygenase and cyclooxygenase inhibitors on the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate and isoproterenol in mouse tissues in vivo.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzoquinones; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Induction; Female; Indomethacin; Isoproterenol; Kidney; Lipoxygenase Inhibitors; Liver; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbols; Pyrazoles; Quinones; Spleen; Tetradecanoylphorbol Acetate | 1986 |
Inhibition of the release of a neutrophil chemotactic factor from macrophages partially explains the anti-inflammatory action of glucocorticoids.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Chemotactic Factors; Dexamethasone; Glucocorticoids; In Vitro Techniques; Indomethacin; Interleukin-8; Lipopolysaccharides; Macrophages; Peritoneum; Pyrazoles; Rats; Ultrafiltration | 1986 |
Adhesion of human platelets to collagen in the presence of prostacyclin, indomethacin and compound BW 755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adult; Blood Proteins; Chlorpromazine; Collagen; Epoprostenol; Humans; In Vitro Techniques; Indomethacin; Phosphatidic Acids; Phosphorylation; Platelet Adhesiveness; Protein Kinase C; Pyrazoles | 1986 |
Lipoxygenase metabolites of arachidonic acid modulate hematopoiesis.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Colony-Forming Units Assay; Erythrocytes; Erythropoiesis; Granulocytes; Hematopoiesis; Humans; Indomethacin; Lipoxygenase; Macrophages; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Tetradecanoylphorbol Acetate | 1986 |
Studies on vascular permeability increasing factors involved in 48-hour homologous PCA in the mouse ear.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alprostadil; Animals; Capillary Permeability; Drug Synergism; Ear; Female; Histamine; Indomethacin; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Passive Cutaneous Anaphylaxis; Pyrazoles; Serotonin; SRS-A; Time Factors | 1986 |
Synergistic actions of paf-acether and sodium arachidonate in human platelet aggregation. 2. Unexpected results after aspirin intake.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine; Administration, Oral; Adult; Apyrase; Arachidonic Acids; Aspirin; Catechols; Drug Synergism; Epoprostenol; Humans; Indomethacin; Masoprocol; Platelet Activating Factor; Platelet Aggregation; Pyrazoles; Thromboxane B2; Time Factors; Umbelliferones | 1986 |
Evidence for the role of leukotrienes C4 and D4 as essential intermediates in CSF-stimulated human myeloid colony formation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Bone Marrow Cells; Catechols; Colony-Forming Units Assay; Colony-Stimulating Factors; Granulocytes; Hematopoiesis; Humans; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Pyrazoles; SRS-A | 1986 |
In vitro effects of aspirin and non steroidal anti-inflammatory drugs on the formation of 12-hydroxyeicosatetraenoic acid by platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Collagen; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Lipoxygenase; Platelet Aggregation; Pyrazoles; Sodium Salicylate; Thromboxane B2 | 1986 |
Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Cell Count; Blood Platelets; Bronchi; Female; Guinea Pigs; Indomethacin; Lung; Male; Microscopy, Electron; N-Formylmethionine Leucyl-Phenylalanine; Pyrazoles; Thromboxane B2 | 1986 |
The synthesis of eicosanoids induced by anaphylaxis in guinea-pig isolated lungs perfused via the trachea.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anaphylaxis; Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Eicosanoic Acids; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Male; Pyrazoles; SRS-A; Trachea | 1986 |
Exaggerated atrial arachidonate metabolism in rabbit left ventricular myocardial infarction.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Coronary Circulation; Coronary Vessels; Heart Atria; Indomethacin; Kinetics; Myocardial Infarction; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandins; Pyrazoles; Rabbits; SRS-A; Thromboxane B2; Vasoconstriction | 1987 |
Effects of leukotriene D4 and antagonists of arachidonic acid metabolism and calcium entry on guinea pig tracheal muscle responsiveness.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Guinea Pigs; In Vitro Techniques; Indomethacin; Muscle Contraction; Nifedipine; Potassium Chloride; Pyrazoles; SRS-A; Trachea | 1986 |
Pharmacological studies on nonimmunologic contact urticaria in guinea pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Capsaicin; Chlorpheniramine; Dermatitis, Contact; Dexamethasone; Female; Guinea Pigs; Indomethacin; Male; Premedication; Pyrazoles; Ranitidine; Urticaria | 1986 |
Mechanism of arachidonic acid-induced Ca2+ mobilization from rat liver microsomes.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Fatty Acids; In Vitro Techniques; Indomethacin; Male; Microsomes, Liver; Pyrazoles; Rats; Rats, Inbred Strains | 1987 |
Differential effects of putative inhibitors on cytosolic and membrane associated platelet lipoxygenase.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Adult; Arachidonate Lipoxygenases; Blood Platelets; Cell Membrane; Cytosol; Humans; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Prostaglandin Antagonists; Pyrazoles; Quercetin; Substrate Specificity; Umbelliferones | 1987 |
Salvage of ischemic rabbit ear by BW-755C and steroids, but not by indomethacin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ear; Indomethacin; Ischemia; Methylprednisolone; Naproxen; Necrosis; Pyrazoles; Rabbits | 1987 |
Eicosanoid formation by mammalian intestine. Effects of some intestinal secretagogues.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Cathartics; Colon; Eicosanoic Acids; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Intestines; Mice; Pyrazoles; Rats; Rats, Inbred Strains; Ricinoleic Acids; Species Specificity | 1987 |
Effect of platelet-activating factor on airway vascular permeability: possible mechanisms.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Biomechanical Phenomena; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Lactones; Male; Plant Extracts; Platelet Activating Factor; Platelet Count; Pyrazoles; Respiratory System; Time Factors | 1987 |
Arachidonic acid metabolites and airway epithelium-dependent relaxant factor.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Biological Products; Carbachol; Epithelium; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Male; Masoprocol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Pyrazoles; Trachea | 1987 |
Modulation of natural killing by cyclo- and lipo-oxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Humans; Indomethacin; Killer Cells, Natural; Lipoxygenase Inhibitors; Pyrazoles | 1988 |
Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antioxidants; Basement Membrane; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Furans; Glomerular Filtration Rate; Indomethacin; Kidney Glomerulus; Lipoxygenase Inhibitors; Male; Microscopy, Electron; Perfusion; Phenothiazines; Platelet Activating Factor; Proteins; Proteinuria; Pyrazoles; Rats; Rats, Inbred Strains; Vascular Resistance | 1988 |
Modulation of arteriolar blood flow by inhibitors of arachidonic acid oxidation after thermal injury: possible role for a novel class of vasodilator metabolites.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Arterioles; Burns; Cheek; Cricetinae; Cytochrome P-450 Enzyme System; Indomethacin; Ischemia; Ketoconazole; Male; Mouth Mucosa; Oxidation-Reduction; Pyrazoles; Regional Blood Flow; Vasoconstriction; Vasodilation; Vasodilator Agents | 1988 |
Effects of inhibitors of arachidonic acid metabolism on endotoxin-induced ocular inflammation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Arachidonic Acid; Arachidonic Acids; Clonixin; Endotoxins; Hydroxyeicosatetraenoic Acids; Indomethacin; Male; Prostaglandins; Pyrazoles; Rabbits; Uveitis | 1988 |
The role of arachidonic acid metabolism in IL-3-induced proliferation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Cell Division; Cell Line; Indomethacin; Interleukin-3; Lipoxygenase Inhibitors; Masoprocol; Meclofenamic Acid; Propionates; Pyrazoles | 1988 |
Possible role of leukotrienes in propranolol-induced airway hyperreactivity in sensitized guinea-pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Airway Resistance; Animals; Atropine; Guinea Pigs; Indomethacin; Ovalbumin; Piperazines; Propranolol; Pyrazoles; Respiratory Hypersensitivity; SRS-A | 1987 |
Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catechols; Diterpenes; Dose-Response Relationship, Drug; Embryo Implantation; Female; Ginkgolides; Indomethacin; Kinetics; Lactones; Lipoxygenase Inhibitors; Masoprocol; Platelet Activating Factor; Pyrazoles; Rats; Rats, Inbred Strains; Sulfides | 1988 |
Eicosanoid synthesis inhibition and renal allograft function during acute rejection.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cyclooxygenase Inhibitors; Diuresis; Dogs; Graft Rejection; Indomethacin; Kidney; Kidney Transplantation; Lipoxygenase Inhibitors; Prostaglandins; Pyrazoles; Regional Blood Flow; Thromboxanes; Time Factors | 1988 |
Acute uteroplacental ischemic embryo: lactic acid accumulation and prostaglandin production in the fetal rat brain.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzoquinones; Brain; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Female; Indomethacin; Ischemia; Lactates; Lactic Acid; Lipoxygenase Inhibitors; Masoprocol; Placenta; Pregnancy; Prostaglandins; Prostaglandins E; Prostaglandins F; Pyrazoles; Quinones; Rats; Uterus | 1988 |
Calcium ionophore and phorbol myristate acetate synergistically inhibited proteoglycan biosynthesis in articular chondrocytes by prostaglandin independent mechanism.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Calcimycin; Cartilage, Articular; Diglycerides; Dinoprostone; Drug Synergism; Indomethacin; Prostaglandins E; Proteoglycans; Pyrazoles; Rabbits; Tetradecanoylphorbol Acetate | 1988 |
Arachidonic acid metabolism and insulin secretion by isolated human pancreatic islets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Glucose; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Insulin; Insulin Secretion; Islets of Langerhans; Lipoxygenase Inhibitors; Mass Spectrometry; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Prostaglandins F; Pyrazoles | 1988 |
Involvement of phospholipase A2 activation in tumour cell killing by tumour necrosis factor.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acids; Cell Survival; Dexamethasone; Humans; Indomethacin; Phospholipases; Phospholipases A; Phospholipases A2; Proadifen; Pyrazoles; Quinacrine; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1988 |
Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Dexamethasone; Edema; Female; Foot; Indomethacin; Inflammation; Male; Platelet Activating Factor; Pleura; Pyrazoles; Rats; Rats, Inbred Strains | 1988 |
Increased airways responsiveness to histamine induced by platelet activating factor in the guinea-pig: possible role of lipoxygenase metabolites.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Aspirin; Atropine Derivatives; Bronchi; Female; Guinea Pigs; Histamine; Indomethacin; Lipoxygenase; Male; Masoprocol; Platelet Activating Factor; Pyrazoles; Vagotomy | 1988 |
Role of arachidonic acid metabolites in ethanol vasoaction in rat gastric submucosa.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Ethanol; Gastric Mucosa; Indomethacin; Male; Microcirculation; Muscle, Smooth, Vascular; Pyrazoles; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Mobilization of arachidonic acid in collagen-stimulated human platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Membrane Lipids; Phosphatidic Acids; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Pyrazoles | 1988 |
Endothelium-dependent modulation of the pressor activity of arginine vasopressin in the isolated superior mesenteric arterial bed of the rat.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine Vasopressin; Blood Pressure; Cholic Acids; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Masoprocol; Mesenteric Arteries; Methylene Blue; Muscle, Smooth, Vascular; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains | 1988 |
Effects of orpanoxin on arachidonic acid metabolism of human polymorphonuclear leucocytes and platelets in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Chromatography, High Pressure Liquid; Female; Humans; In Vitro Techniques; Indicators and Reagents; Indomethacin; Male; Neutrophils; Propionates | 1988 |
Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Blood Pressure; Coronary Circulation; Dogs; Extremities; Female; Heart; Heart Rate; Hexamethonium Compounds; Indomethacin; Male; Myocardial Contraction; Platelet Activating Factor; Pyrazoles; Regional Blood Flow; Theophylline; Vagotomy; Vasodilation | 1985 |
The effect of BW775C on respiratory distress in the rat induced by arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Indomethacin; Pyrazoles; Rats; Respiratory Distress Syndrome; Time Factors | 1985 |
Possible role of phospholipase A2 action and arachidonic acid metabolism in angiotensin II-mediated aldosterone secretion.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Aldosterone; Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Caffeic Acids; Calcium; Cattle; Cyclooxygenase Inhibitors; Dantrolene; Dose-Response Relationship, Drug; Indomethacin; Lipoxygenase Inhibitors; Phospholipases; Phospholipases A; Phospholipases A2; Pyrazoles; Quinacrine | 1985 |
Prostacyclin production by the deendothelialized rabbit aorta.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Calcimycin; Endothelium; Epoprostenol; Indomethacin; Kinetics; Male; Pyrazoles; Rabbits | 1985 |
Pharmacological modulation of responses of guinea-pig airways contracted with antigen and calcium ionophore A23187.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; Calcimycin; Catechols; Chromones; Drug Interactions; Epoprostenol; Guinea Pigs; Indomethacin; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Muscle Contraction; Ovalbumin; Pyrazoles; Pyrazolones; Trachea | 1985 |
Modulation by drugs of leukotriene and prostaglandin production from mouse peritoneal macrophages.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetaminophen; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Dinoprostone; Dipyrone; Indomethacin; Macrophages; Male; Mice; Propionates; Prostaglandins E; Pyrazoles; Pyrazolones; SRS-A | 1985 |
Role of prostanoids in the protective actions of BW755C on the gastric mucosa.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Blood Platelets; Body Fluids; Ethanol; Gastric Mucosa; Hydrogen-Ion Concentration; Indomethacin; Male; Prostaglandins; Pyrazoles; Rats; Rats, Inbred Strains; Thromboxanes | 1985 |
The mechanism of the inhibitory effect of progesterone on lymphocyte cytotoxicity: II. Relationship between cytotoxicity and the cyclooxygenase pathway of arachidonic acid metabolism.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Cytotoxicity, Immunologic; Female; Humans; Indomethacin; Kinetics; Lipopolysaccharides; Lymphocytes; Pregnancy; Progesterone; Prostaglandin-Endoperoxide Synthases; Pyrazoles | 1985 |
Increased metabolism of arachidonic acid in an immune model of colitis in guinea-pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, Thin Layer; Colitis, Ulcerative; Dinitrochlorobenzene; Disease Models, Animal; Guinea Pigs; Immunization; Indomethacin; Male; Prostaglandins; Pyrazoles; Radioimmunoassay | 1985 |
Inhibition of polymorphonuclear leukocyte 5-lipoxygenase and platelet cyclooxygenase by alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolacto ne (KME-4), a new anti-inflammatory drug.
Topics: 4-Butyrolactone; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Arachidonate Lipoxygenases; Blood Platelets; Calcimycin; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Furans; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Neutrophils; Pyrazoles; Rabbits | 1985 |
Ozone-induced bronchial hyperreactivity in guinea pigs is abolished by BW 755C or FPL 55712 but not by indomethacin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Airway Resistance; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Bronchi; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Lipoxygenase; Male; Ozone; Pyrazoles; SRS-A | 1985 |
Possible non-involvement of lipoxygenase pathway in the cerebral blood flow decrease due to indomethacin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Catechols; Cerebrovascular Circulation; Chromones; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Prostaglandins; Pyrazoles; Rats; Rats, Inbred Strains; Regional Blood Flow; SRS-A; Vasoconstriction | 1985 |
Pharmacological modulation of activation-secretion of rat serosal mast cells by chymase, an endogenous secretory granule protease.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Catechols; Chymases; Deoxyadenosines; Dideoxyadenosine; Diethylcarbamazine; Dose-Response Relationship, Drug; Endopeptidases; Exocytosis; Hexosaminidases; Immunoglobulin E; In Vitro Techniques; Indomethacin; Masoprocol; Mast Cells; Prostaglandin D2; Prostaglandins D; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Serine Endopeptidases; Theophylline | 1985 |
Effects of calmodulin and lipoxygenase inhibitors on LH (lutropin)- and LHRH (luliberin)-agonist-stimulated steroidogenesis in rat Leydig cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Calmodulin; Imidazoles; In Vitro Techniques; Indomethacin; Leydig Cells; Lipoxygenase Inhibitors; Luteinizing Hormone; Male; Propionates; Pyrazoles; Rats; Testosterone; Trifluoperazine | 1985 |
The modulation of peritoneal macrophage chemiluminescence by acute pleural inflammation, prostanoids and cyclo/lipoxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acute Disease; Animals; Catechols; Cyclooxygenase Inhibitors; Dinoprostone; Epoprostenol; Indomethacin; Ketoprofen; Lipoxygenase Inhibitors; Luminescent Measurements; Macrophages; Male; Masoprocol; Peritoneal Cavity; Pleurisy; Prostaglandins; Prostaglandins E; Pyrazoles; Rats; Rats, Inbred Strains | 1985 |
Rat neutrophil activation and effects of lipoxygenase and cyclooxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antigen-Antibody Complex; Antioxidants; Calcimycin; Catechols; Cyclooxygenase Inhibitors; Cytochalasin B; Ibuprofen; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piroxicam; Pyrazoles; Pyrazolones; Rats; Superoxides; Tetradecanoylphorbol Acetate; Thiazines; Zymosan | 1984 |
Arachidonic acid and leukotriene B4 induce aggregation of human peripheral blood mononuclear leucocytes in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Cell Aggregation; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Indomethacin; Leukocytes; Leukotriene B4; Masoprocol; Neutrophils; Pyrazoles | 1984 |
Beta-endorphin and adrenocorticotropin release from rat adenohypophysis in vitro: evidence for local modulation by arachidonic acid metabolites of the cyclooxygenase and lipoxygenase pathway.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Adrenocorticotropic Hormone; Animals; Arachidonic Acids; beta-Endorphin; Catechols; Dinoprostone; Endorphins; In Vitro Techniques; Indomethacin; Male; Masoprocol; Pituitary Gland, Anterior; Prostaglandins E; Pyrazoles; Rats; Rats, Inbred Strains | 1984 |
Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bile; Chromones; Dexamethasone; Diethylcarbamazine; Endotoxins; Female; Ibuprofen; Indomethacin; Leukotriene B4; Liver; Metabolic Clearance Rate; Mice; Pyrazoles; Rats; Rats, Inbred Strains; Shock, Septic; SRS-A | 1984 |
Inhibition of the release of slow-reacting substance of anaphylaxis by inhibitors of lipoxygenase activity.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzoxazoles; Guinea Pigs; Indomethacin; Lipoxygenase Inhibitors; Piroxicam; Propionates; Pyrazoles; Pyridines; SRS-A; Thiazines | 1980 |
The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Aspirin; Cell Movement; Dexamethasone; Dinoprostone; Exudates and Transudates; Fatty Acids, Unsaturated; Indomethacin; Inflammation; Leukocyte Count; Leukocytes; Leukotriene B4; Male; Prostaglandins E; Pyrazoles; Rats; Thromboxane B2 | 1983 |
On the role of arachidonic acid metabolites in mast-cell mediated mitogenesis in the rat.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; DNA; Histamine; Indomethacin; Lipoxygenase Inhibitors; Male; Mast Cells; Mesentery; Mitosis; p-Methoxy-N-methylphenethylamine; Phospholipases A; Phospholipases A2; Prostaglandins; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; SRS-A | 1984 |
Inflammatory properties of lipoxygenase products and the effects of indomethacin and BW755C on prostaglandin production, leukocyte migration, and plasma exudation in rabbit skin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Arachidonate Lipoxygenases; Arachidonic Acids; Cell Movement; Indomethacin; Inflammation; Leukocytes; Lipoxygenase; Prostaglandins; Pyrazoles; Rabbits; Skin | 1982 |
Inhibition of mononuclear leukocyte accumulation by the arachidonic acid lipoxygenase inhibitor BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; Carrageenan; Indomethacin; Inflammation; Kinetics; Lipoxygenase Inhibitors; Male; Monocytes; Neutrophils; Pyrazoles; Rats | 1983 |
In vivo and in vitro effects of arachidonic acid products on liver cell integrity following carbon tetrachloride poisoning.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alanine Transaminase; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Carbon Tetrachloride Poisoning; Epoprostenol; Female; Indomethacin; Liver; Lysine; Peroxides; Prostaglandins; Pyrazoles; Rats; Rats, Inbred Strains | 1983 |
Effect of medroxyprogesterone acetate and of some antiinflammatory agents on mouse erythroleukemia cell differentiation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Aspirin; Cell Differentiation; Cell Line; Dexamethasone; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flurbiprofen; Indomethacin; Leukemia, Erythroblastic, Acute; Medroxyprogesterone; Medroxyprogesterone Acetate; Mice; Pyrazoles; Time Factors | 1984 |
Release of leukotriene B4 from human neutrophils measured by specific radioimmunoassay.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Calcimycin; Cytochalasin B; Dinoprostone; Humans; Indomethacin; Kinetics; Leukotriene B4; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Prostaglandins E; Pyrazoles; Radioimmunoassay; Thromboxane B2 | 1983 |
Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Dexamethasone; Foreign-Body Reaction; Indomethacin; Inflammation; Leukocytes; Leukotriene B4; Male; Pyrazoles; Rats; SRS-A | 1984 |
Arachidonic acid metabolism in the murine eosinophil. III. Effect of nonsteroid anti-inflammatory drugs on lymphokine-directed eosinophil migration in vivo.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Aspirin; Catechols; Cell Migration Inhibition; Dose-Response Relationship, Drug; Eosinophils; Indomethacin; Lymphokines; Male; Masoprocol; Mice; Mice, Inbred CBA; Pyrazoles; Rats | 1983 |
Biosynthesis of lipoxygenase products by ocular tissues.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Cats; Conjunctiva; Dogs; Guinea Pigs; Haplorhini; Indomethacin; Iris; Lipoxygenase; Pyrazoles; Rabbits | 1983 |
Selective inhibition of the lipoxygenase metabolic pathway of arachidonic acid by the SRS-A antagonist, FPL 55712.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Chromones; Cyclooxygenase Inhibitors; Indomethacin; Lipoxygenase Inhibitors; Pyrazoles; Rats; SRS-A | 1983 |
A rapid method for detecting inhibitors of both cyclo-oxygenase lipoxygenase metabolites of arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic Acid; Arachidonic Acids; Ascitic Fluid; Biotransformation; Calcimycin; Catechols; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Indomethacin; Lipoxygenase Inhibitors; Male; Masoprocol; Neutrophils; Oxygenases; Propionates; Pyrazoles | 1983 |
Soybean lipoxygenase inhibition by nonsteroidal antiinflammatory drugs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Glycine max; Indomethacin; Kinetics; Lipoxygenase Inhibitors; Naproxen; Piroxicam; Plants; Pyrazoles; Structure-Activity Relationship; Thiazines | 1983 |
The lipoxygenase pathway and tracheal muscle contraction.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Histamine; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Muscle Contraction; Pyrazoles; Swine; Trachea | 1983 |
Pharmacological effects of non-steroidal antiinflammatory agents on prostaglandin and leukotriene synthesis in mouse peritoneal macrophages.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ascitic Fluid; Aspirin; Female; Guinea Pigs; Ibuprofen; Indomethacin; Macrophages; Male; Mice; Propionates; Prostaglandins; Pyrazoles; SRS-A; Zymosan | 1983 |
Effects of antiinflammatory agents on chronic Salmonella typhimurium infection in a mouse model.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Chronic Disease; Eating; Feces; Female; Hydrocortisone; Immunity, Innate; Indomethacin; Liver; Mice; Mice, Inbred CBA; Pyrazoles; Salmonella Infections, Animal; Salmonella typhimurium; Spleen | 1983 |
Effects of cyclooxygenase and lipoxygenase inhibition on lung fluid balance after thrombin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cyclooxygenase Inhibitors; Indomethacin; Ketoprofen; Lipoxygenase Inhibitors; Lung; Pyrazoles; Thrombin; Water-Electrolyte Balance | 1983 |
Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Colitis, Ulcerative; Colon; Humans; Indomethacin; Intestinal Mucosa; Lipoxygenase; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Thromboxane B2 | 1983 |
Indomethacin enhances the effect of histamine on airways resistance in the anaesthetized guinea-pig.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Airway Resistance; Anesthesia; Animals; Drug Synergism; Guinea Pigs; Histamine; Indomethacin; Lung Compliance; Male; Propranolol; Pyrazoles; Reserpine | 1983 |
Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anesthesia; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Dexamethasone; Dogs; Hydroxyurea; Indomethacin; Lymphocyte Activation; Male; Myocardial Infarction; Myocardium; Neutrophils; Pyrazoles | 1984 |
Effects of antioxidants on cyclooxygenase and lipoxygenase activities in intact human platelets: comparison with indomethacin and ETYA.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Antioxidants; Blood Platelets; Catechols; Fatty Acids, Unsaturated; Humans; Indomethacin; Lipoxygenase; Masoprocol; Naphthols; Propyl Gallate; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Quercetin | 1983 |
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alkynes; Arachidonic Acids; Blood Platelets; Catechols; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Leukocytes; Lipoxygenase Inhibitors; Masoprocol; Pyrazoles | 1984 |
Arachidonic acid metabolism and thyrotropin secretion in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Catechols; Female; In Vitro Techniques; Indomethacin; Masoprocol; Phospholipases A; Phospholipases A2; Pituitary Gland; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thyrotropin; Thyrotropin-Releasing Hormone | 1984 |
Stimulation by BW755C and inhibition by cysteamine of duodenal epithelial alkaline secretion suggest a role of endogenous prostaglandin in mucosal protection.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Bicarbonates; Cysteamine; Duodenum; Hydrogen-Ion Concentration; Indomethacin; Intestinal Mucosa; Male; Prostaglandins; Pyrazoles; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Stimulation of mucosal bicarbonate secretion in rat duodenum in vivo by BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bicarbonates; Dinoprostone; Duodenum; Indomethacin; Intestinal Mucosa; Male; Prostaglandins E; Pyrazoles; Rats | 1984 |
Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Anti-Inflammatory Agents; Arachidonate Lipoxygenases; Aspirin; Catechols; In Vitro Techniques; Indomethacin; Leydig Cells; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Pregnenolone; Propionates; Pyrazoles; Rats; Testosterone | 1984 |
Pharmacological studies into cyclo-oxygenase, lipoxygenase and phospholipase in smooth muscle contraction in the isolated trachea.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; Cyclooxygenase Inhibitors; Female; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle, Smooth; Phospholipases; Phospholipases A; Pyrazoles; Quinacrine; Swine; Trachea | 1984 |
Differential effects of putative lipoxygenase inhibitors on arachidonic acid metabolism in cell-free and intact cell preparations.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Catechols; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Neutrophils; Pyrazoles; Quercetin; Rats | 1984 |
Gastric mucosal protection with chronic mild restraint: role of endogenous prostaglandins.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Dinoprostone; Ethanol; Gastric Mucosa; Humans; Indomethacin; Male; Prostaglandins; Prostaglandins E; Pyrazoles; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Physiological; Stress, Psychological; Time Factors | 1984 |
Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Antibody-Dependent Cell Cytotoxicity; Antioxidants; Arachidonic Acid; Arachidonic Acids; Catechols; Cell Line; Humans; Indomethacin; Killer Cells, Natural; Leukemia, Myeloid, Acute; Masoprocol; Pyrazoles | 1984 |
Effect of inhibitors of the lipoxygenase pathway on mouse myoblast fusion.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cell Fusion; Cells, Cultured; Cyclooxygenase Inhibitors; Indomethacin; Lipoxygenase Inhibitors; Mice; Muscles; Pyrazoles; Umbelliferones | 1984 |
Therapeutic reduction of ongoing carrageenin-induced inflammation by lipoxygenase, but not cyclooxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Aspirin; Carrageenan; Cyclooxygenase Inhibitors; Indomethacin; Inflammation; Lipoxygenase; Male; Pyrazoles; Rats; Time Factors | 1984 |
The effect of arachidonic acid metabolism on intravascular platelet aggregation in rats.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Chromatography, Thin Layer; Collagen; Indomethacin; Piroxicam; Platelet Aggregation; Propionates; Pyrazoles; Radioimmunoassay; Rats; Thiazines; Thromboxane B2 | 1984 |
Arachidonic acid-induced human platelet aggregation independent of cyclooxygenase and lipoxygenase.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium Chloride; Humans; Indomethacin; L-Lactate Dehydrogenase; Lipoxygenase; Microscopy, Electron; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Serotonin | 1984 |
On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alprostadil; Anaphylaxis; Animals; Anti-Inflammatory Agents; Epoprostenol; Female; Histamine; Indomethacin; Inflammation; Male; Mice; Mice, Inbred Strains; Norepinephrine; Platelet Activating Factor; Prostaglandins E; Pyrazoles; Rats; Rats, Inbred Strains; Serotonin; Vasopressins | 1984 |
Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Cyclooxygenase Inhibitors; Indomethacin; Leukocytes; Lipoxygenase Inhibitors; Pyrazoles; Rabbits | 1980 |
Comparison of the anti-inflammatory effects of dexamethasone, indomethacin and BW755C on carrageenin-induced pleurisy in rats.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Carrageenan; Dactinomycin; Dexamethasone; Disease Models, Animal; Indomethacin; Male; Pleurisy; Pyrazoles; Rats; Rats, Inbred Strains | 1982 |
Effect of ETYA and BW 755c on arachidonate-induced contractions in the guinea-pig isolated trachea.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Airway Resistance; Animals; Arachidonic Acid; Arachidonic Acids; Drug Interactions; Fatty Acids, Unsaturated; Guinea Pigs; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Pyrazoles; Trachea | 1982 |
The salvage of ischaemic myocardium by BW755C in anaesthetised dogs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Coronary Disease; Disease Models, Animal; Dogs; Indomethacin; Male; Myocardial Infarction; Pyrazoles; Risk | 1982 |
The effect of mixed inhibitors of cyclo-oxygenase and lipoxygenase on the indomethacin-induced hyper-reactivity in the isolated trachea of the pig.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Airway Resistance; Animals; Cyclooxygenase Inhibitors; Histamine; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Muscle Contraction; Muscle, Smooth; Pyrazoles; Swine; Trachea | 1982 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Carboxy-Lyases; Dinoprostone; Female; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Mice; Ornithine Decarboxylase Inhibitors; Phorbols; Prostaglandins E; Pyrazoles; Skin; Tetradecanoylphorbol Acetate | 1982 |
Interdependence of contractile responses of rat small mesenteric arteries on nitric oxide and cyclo-oxygenase and lipoxygenase products of arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetylcholine; Amino Acid Oxidoreductases; Animals; Arachidonic Acid; Arginine; Cholic Acids; Cyclooxygenase Inhibitors; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Wistar | 1994 |
Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; DNA; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Indomethacin; Kinetics; Liver; Male; Phospholipases A; Phospholipases A2; Phosphotyrosine; Prostaglandins; Rats; Rats, Wistar; Tyrosine | 1995 |
BW-755C diminishes smoke-induced pulmonary edema.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Blood Pressure; Body Fluids; Cardiac Output; Eicosanoids; Gossypium; Indomethacin; Pulmonary Circulation; Pulmonary Edema; Pulmonary Wedge Pressure; Sheep; Smoke Inhalation Injury; Vascular Resistance | 1995 |
Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C. 1980.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; Cyclooxygenase Inhibitors; History, 20th Century; Indomethacin; Leukocytes | 1994 |
In vitro demonstration of a positive effect of rhein anthrone on peristaltic reflex of guinea pig ileum.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anthracenes; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Male; Muscle Contraction; Peristalsis; Prostaglandins; Reflex | 1993 |
Involvement of leukotrienes in allergic inflammation in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; Aspirin; Autacoids; Edema; Immunization; Immunization, Secondary; Indomethacin; Inflammation; Leukotriene Antagonists; Leukotrienes; Male; Membrane Proteins; Mice; Receptors, Leukotriene; Tetrazoles | 1994 |
Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Analgesia; Animals; Calcimycin; Dinoprostone; Female; Indomethacin; Kinetics; Leukocyte Count; Leukotriene B4; Mice; Neutrophils; Pleurisy; Radioimmunoassay; Xanthenes | 1994 |
Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acrolein; Animals; Benzofurans; Blood Proteins; Cyclooxygenase Inhibitors; Eicosanoids; Indomethacin; Inflammation Mediators; Lipoxygenase Inhibitors; Lymph; Oxygen Consumption; Pulmonary Circulation; Sheep; Smoke Inhalation Injury; Thromboxane-A Synthase; Vascular Resistance | 1994 |
Hypoxia stimulates human endothelial cells to release smooth muscle cell mitogens: role of prostaglandins and bFGF.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Aorta; Cell Division; Cell Hypoxia; Cells, Cultured; Culture Media, Conditioned; Cycloheximide; Endothelium, Vascular; Fibroblast Growth Factor 2; Gas Chromatography-Mass Spectrometry; Growth Substances; Humans; Indomethacin; Leucine; Models, Biological; Muscle, Smooth, Vascular; Prostaglandins; Rats; Umbilical Veins | 1994 |
The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Brain; Choline O-Acetyltransferase; Cyclooxygenase Inhibitors; Glutamate Decarboxylase; Ibuprofen; Indomethacin; Isoindoles; Kainic Acid; Lipoxygenase Inhibitors; Male; Organ Specificity; Organoselenium Compounds; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Relative roles of nitric oxide and cyclo-oxygenase and lipoxygenase products of arachidonic acid in the contractile responses of rat renal arcuate arteries.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetylcholine; Animals; Arachidonic Acid; Arginine; Arteries; Cholic Acids; Cyclooxygenase Inhibitors; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Renal Circulation | 1994 |
Influence of rhein anthrone on peristaltic reflex of guinea-pig isolated ileum: involvement of prostaglandins.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anthracenes; Anthraquinones; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Peristalsis; Prostaglandins | 1993 |
Renovascular actions of angiotensin II in the isolated kidney of the rat: relationship to lipoxygenases.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Angiotensin II; Animals; Butylated Hydroxytoluene; Cyclooxygenase Inhibitors; Filtration; Flavanones; Flavonoids; Glomerular Filtration Rate; In Vitro Techniques; Indomethacin; Kidney; Lipoxygenase; Lipoxygenase Inhibitors; Male; Perfusion; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Vascular Resistance | 1993 |
LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Dexamethasone; Hydroxyurea; Indomethacin; Leukocyte Count; Leukotriene B4; Male; Models, Biological; Naproxen; Neutropenia; Neutrophils; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene B4 | 1993 |
Effects of systemic indomethacin, meclizine, and BW755C on chronic ultraviolet B-induced effects in hairless mouse skin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Female; Indomethacin; Macromolecular Substances; Meclizine; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Skin; Skin Neoplasms; Ultraviolet Rays | 1993 |
Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Calcium; Carbon Radioisotopes; Cell Hypoxia; Endothelium, Vascular; Humans; Indomethacin; Kinetics; Oxygen; Phospholipases A; Phospholipases A2; Prostaglandins; Quinacrine; Stearic Acids; Tritium; Umbilical Veins; Verapamil | 1993 |
Reducing ischemia-reperfusion injury in rat island groin flaps by dexamethasone and BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dexamethasone; Fascia; Graft Survival; Groin; Indomethacin; Ischemia; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Neutrophils; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Skin Transplantation; Surgical Flaps | 1995 |
Role of endothelium-derived metabolites of arachidonic acid in enhanced pulmonary artery contractions in female rabbits.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Endothelium, Vascular; Female; Indomethacin; Lipoxygenase Inhibitors; Male; Masoprocol; Methacholine Chloride; Potassium Chloride; Pulmonary Artery; Rabbits; Sex Characteristics; Thromboxane B2; Vasoconstriction | 1996 |
The pharmacological profile of mouse hind paw inflammation induced by staphylococcal enterotoxin type A.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Capsaicin; Cimetidine; Dexamethasone; Diphenhydramine; Edema; Enterotoxins; Enzyme Inhibitors; Hindlimb; Histamine Antagonists; Indomethacin; Inflammation; Male; Mice; Platelet Aggregation Inhibitors; Triazoles | 1997 |
Prostanoid receptors of the EP3 subtype mediate inhibition of evoked [3H]acetylcholine release from isolated human bronchi.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetylcholine; Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Humans; In Vitro Techniques; Indomethacin; Prostaglandins; Receptors, Prostaglandin E; Tritium | 1998 |
Arachidonic acid, but not its metabolites, is essential for FcgammaR-stimulated intracellular killing of Staphylococcus aureus by human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Immunoglobulin G; Indomethacin; Lipoxygenase Inhibitors; Monocytes; Oxygen; Phagocytosis; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, IgG; Staphylococcus aureus; Sulfonamides | 1999 |
Mouse macrophages release a neutrophil chemotactic mediator following stimulation by staphylococcal enterotoxin type A.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzamides; Calcium; Capsaicin; Chemotactic Factors; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Dexamethasone; Drug Stability; Enterotoxins; Glucocorticoids; Glucose; Indomethacin; Macrophages, Peritoneal; Magnesium; Male; Mice; Molecular Weight; Neutrophils; Piperidines; Receptors, Neurokinin-2; Thioglycolates | 2001 |
Evidence for the involvement of a macrophage-derived chemotactic mediator in the neutrophil recruitment induced by staphylococcal enterotoxin B in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzeneacetamides; Capsaicin; Chemotaxis, Leukocyte; Cimetidine; Dexamethasone; Diterpenes; Enterotoxins; Enzyme Inhibitors; Ginkgolides; Hydroxamic Acids; Indomethacin; Interleukin-8; Lactones; Macrophages, Peritoneal; Male; Mice; Neutrophil Infiltration; Piperidines; Quinuclidines; Rats; Rats, Wistar | 2002 |
Isolation of a haemorrhagic protein toxin (SA-HT) from the Indian venomous butterfish (Scatophagus argus, Linn) sting extract.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capillaries; Chromatography, Ion Exchange; Cyproheptadine; Dose-Response Relationship, Drug; Edema; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Female; Fish Proteins; Fish Venoms; Gastrointestinal Agents; Guinea Pigs; Indomethacin; Lipoxygenase; Mice; Muscle, Smooth; Perciformes; Permeability; Rats; Spine; Superoxide Dismutase; Time Factors; Trypsin; Ultraviolet Rays; Uterus | 2004 |
Lethal, oedema, haemorrhagic activity of spotted butterfish (Scatophagus argus, Linn) sting extract and its neutralization by antiserum and pharmacological antagonists.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cyproheptadine; Edema; Edetic Acid; Fish Venoms; Hemagglutination; Hemorrhage; Immune Sera; Indomethacin; Inflammation; Male; Mice; Perciformes; Rabbits; Rats; Temperature; Time Factors; Ultraviolet Rays | 2005 |
15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetylcholine; Age Factors; Aging; Animals; Apamin; Arachidonate 15-Lipoxygenase; Blood Pressure; Charybdotoxin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Eicosanoids; Hypotension; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium Channel Blockers; Rabbits; Vasodilation; Vasodilator Agents | 2008 |