bw 306u and bupropion

bw 306u has been researched along with bupropion in 32 studies

*Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE. [MeSH]

*Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE. [MeSH]

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.13)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's26 (81.25)24.3611
2020's5 (15.63)2.80

Authors

AuthorsStudies
De Vane, CL; Golden, RN; Laizure, SC; Potter, WZ; Rudorfer, MV; Sherer, MA1
Carroll, FI; Damaj, MI; Grabus, SD1
Chen, X; Gao, L; He, Y; Huang, Z; Liu, F; Liu, Z; Ouyang, D; Tang, J; Yin, J; Zhang, W; Zhou, H1
Al-Abri, SA; Benowitz, NL; Hayashi, S; Olson, KR; Orengo, JP; Thoren, KL1
Chen, X; He, J; Prasad, B; Unadkat, JD; Yu, Y1
Brünen, S; Hiemke, C; Laib, AK; Pfeifer, P; Vincent, P1
Blough, BE; Carroll, FI; Damaj, MI; Lukas, RJ; Mascarella, SW; Navarro, HA1
Dinger, J; Maurer, HH; Meyer, MR1
Clarke, W; Jannetto, PJ; Johnson-Davis, KL; Langman, LJ; Marzinke, MA; Moskowitz, J; Petrides, AK1
Haslemo, T; Høiseth, G; Molden, E; Uthus, LH1
Blough, B; Carroll, FI; Damaj, MI; Malcolm, E; Shoaib, M1
Chen, L; Li, J; Tian, L; Zhang, C1
Dai, H; Gaedigk, A; Gaedigk, R; Leeder, JS; Pearce, RE; Riffel, AK; Twist, GP1
Cremers, TI; Flik, G; Folgering, JH; Rollema, H; Stratford, RE1
Ahmed, MS; Clark, SM; Fokina, VM; Hankins, GD; Nanovskaya, TN; Oncken, C; West, H1
Flaker, AM; Kharasch, ED; Teitelbaum, AM1
Cao, SP; Cheng, L; Dai, HY; Gao, LC; Liu, FQ; Tang, J; Tao, R; Wang, D; Yang, L1
Isoherranen, N; Price, LS; Sager, JE1
Abdel-Rahman, SZ; Ahmed, MS; Clark, SM; Fokina, VM; Hankins, GD; Nanovskaya, TN; Oncken, C; Rytting, E; West, H; Xu, M1
Blanton, MP; Jansen, M; Pandhare, A; Pappu, AS; Wilms, H1
Babiskin, A; Connarn, JN; Ellingrod, VL; Harrington, G; Kamali, M; Kelly, M; Luo, R; McInnis, M; Sun, D; Windak, J; Zhang, X1
Chen, JY; Chen, Y; Huang, XT; Wang, JJ1
Bhatt, NM; Chavada, VD; Sanyal, M; Shrivastav, PS1
Capron, A; De Boosere, E; Schmit, G; Vanhaebost, J1
Dash, RP; Rais, R; Srinivas, NR1
Dang, H; Ma, H; Ma, Y; Wei, S; Yang, X; Zhang, H; Zhang, W; Zhang, Y1
Menke, A; Scherf-Clavel, M; Unterecker, S; Wahl, O1
Gaebler, AJ; Paulzen, M; Schneider, KL; Stingl, JC1
Bishop, JR; Eum, S; Lee, AM; Sayre, F; Stingl, JC1
Ahluwalia, JS; Benowitz, NL; Chenoweth, MJ; Cox, LS; Knight, J; Nollen, NL; Peng, AR; Swardfager, W; Tyndale, RF; Zhu, AZX1
Dinh, J; Harbeson, S; Morgan, AJ; Pelletier, R; Raccor, B; Shi, Y; Totah, RA; Uttamsingh, V; Yusuff, N1
Bach, C; Bhattacharya, CS; Masters, AR; Sinn, AL; Stratford, RE; Trowbridge, MA1

Reviews

3 review(s) available for bw 306u and bupropion

ArticleYear
Bupropion and bupropion analogs as treatments for CNS disorders.
    Advances in pharmacology (San Diego, Calif.), 2014, Volume: 69

    Topics: Animals; Bupropion; Central Nervous System Diseases; Humans; Protein Binding; Treatment Outcome

2014
Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion.
    Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:9

    Topics: Antidepressive Agents, Second-Generation; Biological Availability; Bupropion; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Drug Interactions; Humans; Inactivation, Metabolic; Stereoisomerism

2018
Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis.
    Pharmacotherapy, 2022, Volume: 42, Issue:1

    Topics: Bupropion; Cytochrome P-450 CYP2B6; Genotype; Humans; Polymorphism, Genetic

2022

Trials

5 trial(s) available for bw 306u and bupropion

ArticleYear
Bupropion in depression. II. The role of metabolites in clinical outcome.
    Archives of general psychiatry, 1988, Volume: 45, Issue:2

    Topics: Adult; Aged; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Half-Life; Humans; Male; Middle Aged; Outcome and Process Assessment, Health Care; Propiophenones

1988
Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Adult; Bupropion; Coumaric Acids; Cross-Over Studies; Cytochrome P-450 CYP2B6; Drug Interactions; Genetic Variation; Genotype; Humans; Hydroxylation; Male; Polymorphism, Single Nucleotide; Pregnane X Receptor; Receptors, Steroid; Young Adult

2013
The P450 oxidoreductase (POR) rs2868177 and cytochrome P450 (CYP) 2B6*6 polymorphisms contribute to the interindividual variability in human CYP2B6 activity.
    European journal of clinical pharmacology, 2016, Volume: 72, Issue:10

    Topics: Adult; Area Under Curve; Asian People; Bupropion; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Gene Frequency; Genotype; Healthy Volunteers; Humans; Hydroxylation; Male; Polymorphism, Single Nucleotide; Young Adult

2016
Effects of Genetic Polymorphisms of CYP2B6 on the Pharmacokinetics of Bupropion and Hydroxybupropion in Healthy Chinese Subjects.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Apr-11, Volume: 24

    Topics: Adolescent; Adult; Area Under Curve; Asian People; Bupropion; China; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP2B6; Genotype; Healthy Volunteers; Humans; Male; Polymorphism, Single Nucleotide; Tandem Mass Spectrometry; Young Adult

2018
Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis.
    Addiction (Abingdon, England), 2022, Volume: 117, Issue:6

    Topics: Black or African American; Bupropion; Cytochrome P-450 CYP2B6; Female; Humans; Male; Mediation Analysis; Smoking Cessation

2022

Other Studies

24 other study(ies) available for bw 306u and bupropion

ArticleYear
Bupropion and its main metabolite reverse nicotine chronic tolerance in the mouse.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012, Volume: 14, Issue:11

    Topics: Analgesics; Animals; Antidepressive Agents; Body Temperature; Bupropion; Dose-Response Relationship, Drug; Drug Tolerance; Hypothermia, Induced; Male; Mice; Nicotine; Smoking Cessation

2012
Delayed bupropion cardiotoxicity associated with elevated serum concentrations of bupropion but not hydroxybupropion.
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:10

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxins; Drug Overdose; Electrocardiography; Gastrointestinal Tract; Heart Diseases; Humans; Male; Seizures; Status Epilepticus

2013
Mechanism of an unusual, but clinically significant, digoxin-bupropion drug interaction.
    Biopharmaceutics & drug disposition, 2014, Volume: 35, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bupropion; Cardiotonic Agents; Digoxin; Dogs; Dopamine Uptake Inhibitors; Drug Interactions; Female; Humans; Madin Darby Canine Kidney Cells; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Species Specificity

2014
Serum concentrations of hydroxybupropion for dose optimization of depressed patients treated with bupropion.
    Therapeutic drug monitoring, 2014, Volume: 36, Issue:4

    Topics: Antidepressive Agents, Second-Generation; Area Under Curve; Bupropion; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Half-Life; Humans; Male; Middle Aged; Retrospective Studies

2014
Development and validation of a liquid-chromatography high-resolution tandem mass spectrometry approach for quantification of nine cytochrome P450 (CYP) model substrate metabolites in an in vitro CYP inhibition cocktail.
    Analytical and bioanalytical chemistry, 2014, Volume: 406, Issue:18

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Bupropion; Calibration; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Drug Evaluation, Preclinical; Humans; Substrate Specificity; Tandem Mass Spectrometry; Umbelliferones

2014
The development and validation of a turbulent flow-liquid chromatography-tandem mass spectrometric method for the simultaneous quantification of citalopram, sertraline, bupropion and hydroxybupropion in serum.
    Clinical biochemistry, 2014, Volume: 47, Issue:15

    Topics: Antidepressive Agents; Bupropion; Chromatography, Liquid; Citalopram; Drug Stability; Humans; Reproducibility of Results; Sensitivity and Specificity; Sertraline; Solid Phase Extraction; Tandem Mass Spectrometry

2014
Effect of CYP2B6*6 on Steady-State Serum Concentrations of Bupropion and Hydroxybupropion in Psychiatric Patients: A Study Based on Therapeutic Drug Monitoring Data.
    Therapeutic drug monitoring, 2015, Volume: 37, Issue:5

    Topics: Adult; Bupropion; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2D6; Drug Monitoring; Female; Genotype; Humans; Male; Middle Aged; Retrospective Studies

2015
Examination of the metabolite hydroxybupropion in the reinforcing and aversive stimulus effects of nicotine in rats.
    Psychopharmacology, 2015, Volume: 232, Issue:15

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Bupropion; Male; Nicotine; Rats; Receptors, Nicotinic; Reward; Self Administration; Smoking Cessation; Tobacco Use Disorder

2015
Synthesis of deuterium-labeled hydroxybupropion.
    Journal of labelled compounds & radiopharmaceuticals, 2015, Volume: 58, Issue:10

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Deuterium

2015
Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:7

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Biotransformation; Bupropion; Child; Child, Preschool; Cytochrome P-450 CYP2B6; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gene Frequency; Gestational Age; Haplotypes; Humans; Hydroxylation; Infant; Infant, Newborn; Liver; Male; Microsomes, Liver; Middle Aged; Pharmacogenetics; Pharmacogenomic Variants; RNA, Messenger; Substrate Specificity; Young Adult

2016
Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:5

    Topics: Animals; Blood-Brain Barrier; Brain; Bupropion; Dopamine Plasma Membrane Transport Proteins; Extracellular Fluid; Humans; Male; Microdialysis; Norepinephrine Plasma Membrane Transport Proteins; Plasma; Rats; Rats, Sprague-Dawley

2016
Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:4

    Topics: Adult; Amniotic Fluid; Antidepressive Agents, Second-Generation; Bupropion; Depression; Female; Fetal Blood; Fetus; Humans; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnancy Complications; Smoking Cessation

2016
Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Aug-01, Volume: 1027

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Chromatography, High Pressure Liquid; Glucuronides; Humans; Limit of Detection; Oxidation-Reduction; Smoking Cessation; Tandem Mass Spectrometry

2016
Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4'-OH-bupropion in vitro.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:10

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Humans; In Vitro Techniques; Stereoisomerism

2016
Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:11

    Topics: Adult; Alleles; Antidepressive Agents, Second-Generation; Bupropion; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Female; Humans; Polymorphism, Single Nucleotide; Pregnancy; Prospective Studies; Young Adult

2016
The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors.
    Neuropharmacology, 2017, Volume: 113, Issue:Pt A

    Topics: Allosteric Regulation; Animals; Antidepressive Agents, Second-Generation; Bupropion; Dose-Response Relationship, Drug; Granisetron; HEK293 Cells; Humans; Mice; Oocytes; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Xenopus laevis

2017
Identification of non-reported bupropion metabolites in human plasma.
    Biopharmaceutics & drug disposition, 2016, Volume: 37, Issue:9

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Chromatography, Liquid; Humans; Spectrometry, Mass, Electrospray Ionization

2016
In vivo effect of borneol on rat hepatic CYP2B expression and activity.
    Chemico-biological interactions, 2017, Jan-05, Volume: 261

    Topics: Administration, Oral; Animals; Bupropion; Camphanes; Cell Nucleus; Constitutive Androstane Receptor; Cytochrome P450 Family 2; Liver; Male; Microsomes, Liver; Protein Transport; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Regression Analysis; Reproducibility of Results

2017
Design of experiment assisted concurrent enantioseparation of bupropion and hydroxybupropion by high-performance thin-layer chromatography.
    Chirality, 2017, Volume: 29, Issue:2

    Topics: Bupropion; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Research Design; Stereoisomerism; Tartrates

2017
Bupropion Overdose Resulted in a Pharmacobezoar in a Fatal Bupropion (Wellbutrin
    Journal of forensic sciences, 2017, Volume: 62, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Bezoars; Bile; Bupropion; Delayed-Action Preparations; Drug Overdose; Female; Humans; Kidney; Liver; Postmortem Changes; Stomach; Tablets; Tissue Distribution; Vitreous Body

2017
Determination of hydroxybupropion in human serum for routine therapeutic drug monitoring in psychiatry: A tool for dose-individualization in treatment with bupropion.
    Biomedical chromatography : BMC, 2019, Volume: 33, Issue:10

    Topics: Adult; Aged; Bupropion; Chromatography, High Pressure Liquid; Drug Monitoring; Female; Humans; Limit of Detection; Linear Models; Male; Middle Aged; Reproducibility of Results; Retrospective Studies; Solid Phase Extraction; Young Adult

2019
Subtherapeutic bupropion and hydroxybupropion serum concentrations in a patient with CYP2C19*1/*17 genotype suggesting a rapid metabolizer status.
    The pharmacogenomics journal, 2020, Volume: 20, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Cytochrome P-450 CYP2C19; Depressive Disorder, Major; Humans; Male

2020
Selective deuteration of bupropion slows epimerization and reduces metabolism.
    Bioorganic & medicinal chemistry letters, 2022, 11-15, Volume: 76

    Topics: Bupropion; Cytochrome P-450 CYP2B6; Deuterium; Humans; Recombinant Proteins

2022
Characterization of the Stereoselective Disposition of Bupropion and Its Metabolites in Rat Plasma and Brain.
    European journal of drug metabolism and pharmacokinetics, 2023, Volume: 48, Issue:2

    Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Bupropion; Rats; Tandem Mass Spectrometry

2023