Page last updated: 2024-08-21

butorphanol and u-50488

butorphanol has been researched along with u-50488 in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (25.00)	18.7374
1990's	7 (29.17)	18.2507
2000's	9 (37.50)	29.6817
2010's	2 (8.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP	1
Cook, L; Holtzman, SG; Steinfels, GF	1
Dykstra, LA	1
Blake, JW; DeQuick, D; Kamerling, S; Tai, C; Tobin, T; Weckman, TJ; Wood, T	1
Cooper, SJ; Jackson, A; Kirkham, TC	1
Hayes, A; Kelly, A	1
Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM	1
Hart, JC; Leander, JD; Zerbe, RL	1
Leander, JD	1
Butelman, ER; Winger, G; Woods, JH; Zernig, G	1
Feng, YZ; Ho, IK; Hoskins, B; Narita, M; Tseng, YT	1
Barton, C; Bray, GA; Ookuma, K; York, DA	1
Burke, TF; Garner, HR; Lawhorn, CD; Stoner, JM; Wessinger, WD	1
Picker, MJ; Smith, MA	1
Ho, IK; Jang, CG; Ko, KH; Park, Y	1
Natalini, CC; Robinson, EP	2
Cook, DA; Cumberbatch, MJ; Hargreaves, RJ; Hill, RG; Shepheard, SL; Williamson, DJ	1
Billington, CJ; Grace, MK; Jewett, DC; Jones, RM; Levine, AS; Portoghese, PS	1
Mello, NK; Negus, SS	1
French, AM; Smith, MA	1
Ilkiw, JE; Pascoe, PJ; Tripp, LD	1
Li, M; McMillan, DE; Wessinger, WD	1
Anisimova, VA; Grechko, OIu; Spasov, AA	1

Reviews

2 review(s) available for butorphanol and u-50488

Article	Year
Narcotic analgesics, their detection and pain measurement in the horse: a review. Equine veterinary journal, 1989, Volume: 21, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Chromatography, Thin Layer; Cyclazocine; Ethylketocyclazocine; Etorphine; Fentanyl; Horses; Morphine; Pain Measurement; Pentazocine; Pyrrolidines; Radioimmunoassay; Receptors, Opioid	1989
Endorphins and food intake: kappa opioid receptor agonists and hyperphagia. Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Choice Behavior; Cyclazocine; Diuresis; Drinking; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Humans; Morphine; Narcotic Antagonists; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Satiety Response	1985

Article

Year

Narcotic analgesics, their detection and pain measurement in the horse: a review.

Equine veterinary journal, 1989, Volume: 21, Issue:1

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Chromatography, Thin Layer; Cyclazocine; Ethylketocyclazocine; Etorphine; Fentanyl; Horses; Morphine; Pain Measurement; Pentazocine; Pyrrolidines; Radioimmunoassay; Receptors, Opioid

1989

Endorphins and food intake: kappa opioid receptor agonists and hyperphagia.

Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Choice Behavior; Cyclazocine; Diuresis; Drinking; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Humans; Morphine; Narcotic Antagonists; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Satiety Response

1985

Trials

1 trial(s) available for butorphanol and u-50488

Article	Year
Effects of epidural opioid analgesics on heart rate, arterial blood pressure, respiratory rate, body temperature, and behavior in horses. Veterinary therapeutics : research in applied veterinary medicine, 2003,Winter, Volume: 4, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alfentanil; Analgesics, Opioid; Anesthesia, Epidural; Animals; Behavior, Animal; Blood Pressure; Body Temperature; Butorphanol; Cross-Over Studies; Female; Heart Rate; Horses; Injections, Epidural; Male; Morphine; Respiration; Tramadol	2003

Article

Year

Effects of epidural opioid analgesics on heart rate, arterial blood pressure, respiratory rate, body temperature, and behavior in horses.

Veterinary therapeutics : research in applied veterinary medicine, 2003,Winter, Volume: 4, Issue:4

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alfentanil; Analgesics, Opioid; Anesthesia, Epidural; Animals; Behavior, Animal; Blood Pressure; Body Temperature; Butorphanol; Cross-Over Studies; Female; Heart Rate; Horses; Injections, Epidural; Male; Morphine; Respiration; Tramadol

2003

Other Studies

21 other study(ies) available for butorphanol and u-50488

Article	Year
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorganic & medicinal chemistry letters, 2009, Jan-01, Volume: 19, Issue:1 Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol	2009
Discriminative stimulus effects of spiradoline, a kappa-opioid agonist. Psychopharmacology, 1991, Volume: 105, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Discrimination, Psychological; Ethylketocyclazocine; Generalization, Stimulus; Male; Morphine; Nalorphine; Phencyclidine; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Dose-Response Relationship, Drug; Levallorphan; Male; Methadone; Morphinans; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	1990
Profile of activity of kappa receptor agonists in the rabbit vas deferens. European journal of pharmacology, 1985, Apr-16, Volume: 110, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1985
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu	1987
Kappa agonist-induced diuresis: evidence for stereoselectivity, strain differences, independence of hydration variables and a result of decreased plasma vasopressin levels. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Butorphanol; Cyclazocine; Diuresis; Drinking; Ethylketocyclazocine; Female; Male; Nalorphine; Pyrrolidines; Rats; Rats, Inbred Strains; Rats, Zucker; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Vasopressins; Water Deprivation	1987
Kappa opioid agonists and antagonists: effects on drinking and urinary output. Appetite, 1984, Volume: 5, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Clonidine; Cyclazocine; Drinking; Ethylketocyclazocine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vasopressins	1984
Butorphanol: characterization of agonist and antagonist effects in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Butorphanol; Diuresis; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Muscle Relaxation; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration; Self Administration	1995
Crosstolerance between butorphanol and morphine in rats. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Butorphanol; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraventricular; Male; Morphine; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley	1994
Effect of enterostatin and kappa-opioids on macronutrient selection and consumption. Peptides, 1997, Volume: 18, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Colipases; Dietary Carbohydrates; Dietary Fats; Eating; Enzyme Precursors; Food Preferences; Male; Naltrexone; Narcotic Antagonists; Narcotics; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	1997
Butorphanol-mediated antinociception in mice: partial agonist effects and mu receptor involvement. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, mu	1997
Tolerance and cross-tolerance to the rate-suppressing effects of opioids in butorphanol-treated rats: influence of maintenance dose and relative efficacy at the mu receptor. Psychopharmacology, 1998, Volume: 140, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Buprenorphine; Butorphanol; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Male; Naloxone; Phenobarbital; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Sufentanil	1998
kappa-opioid agonist stimulated regional distribution of [(35)S]GTPgammas binding in butorphanol continuously infused rat. Brain research bulletin, 2000, May-01, Volume: 52, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Guanosine 5'-O-(3-Thiotriphosphate); Infusion Pumps; Injections, Intraventricular; Male; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sulfur Radioisotopes; Tissue Distribution	2000
Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. American journal of veterinary research, 2000, Volume: 61, Issue:12 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alfentanil; Analgesia, Epidural; Animals; Avoidance Learning; Butorphanol; Electric Stimulation; Horses; Morphine; Pain; Pain Threshold; Tramadol	2000
Role of opioid receptors in neurogenic dural vasodilation and sensitization of trigeminal neurones in anaesthetized rats. British journal of pharmacology, 2001, Volume: 133, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Blood Vessels; Butorphanol; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Dura Mater; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Morphine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Trigeminal Caudal Nucleus; Vasodilation	2001
The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in rats. Brain research, 2001, Aug-03, Volume: 909, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Butorphanol; Drug Interactions; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Deprivation; Guanidines; Male; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	2001
Effects of gonadal steroid hormone treatments on opioid antinociception in ovariectomized rhesus monkeys. Psychopharmacology, 2002, Volume: 159, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Butorphanol; Dose-Response Relationship, Drug; Drug Therapy, Combination; Estradiol; Female; Gonadal Steroid Hormones; Macaca mulatta; Nalbuphine; Narcotic Antagonists; Ovariectomy; Pain Measurement; Progesterone; Receptors, Opioid, kappa; Receptors, Opioid, mu; Testosterone	2002
Age-related differences in sensitivity to the antinociceptive effects of kappa opioids in adult male rats. Psychopharmacology, 2002, Volume: 162, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Butorphanol; Cold Temperature; Dose-Response Relationship, Drug; Drug Synergism; Male; Nalbuphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred F344; Reaction Time; Receptors, Opioid, kappa	2002
Effects of morphine, butorphanol, buprenorphine, and U50488H on the minimum alveolar concentration of isoflurane in cats. American journal of veterinary research, 2002, Volume: 63, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blood Pressure; Buprenorphine; Butorphanol; Cats; Drug Interactions; Electrocardiography; Female; Isoflurane; Morphine; Pulmonary Alveoli; Random Allocation	2002
Drug discrimination in pigeons trained to discriminate among morphine, U50488, a combination of these drugs, and saline. Behavioural pharmacology, 2011, Volume: 22, Issue:5-6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule; Sodium Chloride	2011
[Model of platelet activation as experimental test system for screening kappa-opioid receptor ligands]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Benzimidazoles; Blood Platelets; Butorphanol; High-Throughput Screening Assays; Ligands; Light; Naltrexone; Platelet Activation; Rabbits; Receptors, Opioid, kappa; Scattering, Radiation	2011