butirosin-sulfate and bekanamycin

butirosin-sulfate has been researched along with bekanamycin* in 2 studies

Other Studies

2 other study(ies) available for butirosin-sulfate and bekanamycin

Article	Year
The complete 1H NMR assignments of aminoglycoside antibiotics and conformational studies of butirosin A through the use of 2D NMR spectroscopy. Carbohydrate research, 1995, Jul-10, Volume: 271, Issue:1 The complete proton assignments of the aminoglycoside antibiotics, butirosin A, kanamycin A and kanamycin B, at pH 6.5 have been made through the use of various homonuclear and heteronuclear 2D NMR methods. Butirosin A NOESY experiments suggest a stacking arrangement between the xylose and 2,6-diamino-2,6-dideoxyglucose rings, while the 2-deoxystreptamine ring and its substituent, the (S)-4-amino-2-hydroxybutyryl group, extend away from the stacked rings. Informative long-range NOEs were observed for butirosin A but not with kanamycin A or kanamycin B. Many intra-ring NOEs were observed with all three aminoglycosides that confirm the proton assignments made in this study. Topics: Butirosin Sulfate; Carbohydrate Conformation; Carbohydrate Sequence; Hydrogen-Ion Concentration; Kanamycin; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure	1995
[Experimental study on renal tolerability of aminoglycosides butirosin and bekanamycin (author's transl)]. Arzneimittel-Forschung, 1980, Volume: 30, Issue:2 The aminoglycosides butirosin and bekanamycin (Kanendomycin) were tested for their nephrotoxicity in female albino Wistar rats (n = 110). The antibiotics were administered i.m. over a course of 5 days; dosage interval 12 h, dosage 2,5, 5, 10, 20, 100 and 500 mg/kg per day, respectively. For comparative evaluation of nephrotoxicity the urinary excretion of tubular cells and enzymes (MDH, GOT, LDH) were taken. Additionally, serum urea and urine protein (qualitatively) were determined, and the kidneys were investigated histologically. The experiments revealed that both aminoglycosides had tubulotoxic and glomerulotoxic effects. The lowest doses that induced pathologic cell excretion (tubulotoxic threshold doses) were 5 mg/kg per day for either drug. It may be concluded that nephrotoxicity of butirosin and bekanamycin does not differ within the range of dosages which are used in human therapy. Compared with other established aminoglycosides advantages with respect to nephrotoxicity could not be found. Topics: Animals; Anti-Bacterial Agents; Butirosin Sulfate; Enzymes; Female; Kanamycin; Kidney; Kidney Diseases; Proteinuria; Rats; Time Factors; Urea	1980

Article

Year

The complete 1H NMR assignments of aminoglycoside antibiotics and conformational studies of butirosin A through the use of 2D NMR spectroscopy.

Carbohydrate research, 1995, Jul-10, Volume: 271, Issue:1

The complete proton assignments of the aminoglycoside antibiotics, butirosin A, kanamycin A and kanamycin B, at pH 6.5 have been made through the use of various homonuclear and heteronuclear 2D NMR methods. Butirosin A NOESY experiments suggest a stacking arrangement between the xylose and 2,6-diamino-2,6-dideoxyglucose rings, while the 2-deoxystreptamine ring and its substituent, the (S)-4-amino-2-hydroxybutyryl group, extend away from the stacked rings. Informative long-range NOEs were observed for butirosin A but not with kanamycin A or kanamycin B. Many intra-ring NOEs were observed with all three aminoglycosides that confirm the proton assignments made in this study.

Topics: Butirosin Sulfate; Carbohydrate Conformation; Carbohydrate Sequence; Hydrogen-Ion Concentration; Kanamycin; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure

1995

[Experimental study on renal tolerability of aminoglycosides butirosin and bekanamycin (author's transl)].

Arzneimittel-Forschung, 1980, Volume: 30, Issue:2

The aminoglycosides butirosin and bekanamycin (Kanendomycin) were tested for their nephrotoxicity in female albino Wistar rats (n = 110). The antibiotics were administered i.m. over a course of 5 days; dosage interval 12 h, dosage 2,5, 5, 10, 20, 100 and 500 mg/kg per day, respectively. For comparative evaluation of nephrotoxicity the urinary excretion of tubular cells and enzymes (MDH, GOT, LDH) were taken. Additionally, serum urea and urine protein (qualitatively) were determined, and the kidneys were investigated histologically. The experiments revealed that both aminoglycosides had tubulotoxic and glomerulotoxic effects. The lowest doses that induced pathologic cell excretion (tubulotoxic threshold doses) were 5 mg/kg per day for either drug. It may be concluded that nephrotoxicity of butirosin and bekanamycin does not differ within the range of dosages which are used in human therapy. Compared with other established aminoglycosides advantages with respect to nephrotoxicity could not be found.

Topics: Animals; Anti-Bacterial Agents; Butirosin Sulfate; Enzymes; Female; Kanamycin; Kidney; Kidney Diseases; Proteinuria; Rats; Time Factors; Urea

1980