buthionine sulfoximine has been researched along with methionine sulfoximine in 868 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 310 (35.71) | 18.7374 |
| 1990's | 550 (63.36) | 18.2507 |
| 2000's | 5 (0.58) | 29.6817 |
| 2010's | 1 (0.12) | 24.3611 |
| 2020's | 2 (0.23) | 2.80 |
| Authors | Studies |
|---|---|
| Caffrey, PB; Frenkel, GD | 2 |
| Meister, A | 5 |
| Hong, YS; Kang, JH; Kim, DJ; Kim, HK; Lee, KS; Moon, HS; Park, JG | 1 |
| Bonner, JA; Christianson, TJ; Lawrence, TS | 1 |
| Brul, S; Lombardo, MC; Tager, JM; van der Zwaan, JW | 1 |
| Morita, I; Murota, S; Ochi, H | 1 |
| Lafleur, MV; Lankelma, J; Mans, DR; Pinedo, HM; Retèl, J; Schuurhuis, GJ; Treskes, M | 1 |
| Liebross, RH; Wetterhahn, KE | 1 |
| Alvero-Jackson, H; Benathan, M; Frenk, E; Mooy, AM; Scaletta, C | 1 |
| Hansen, LG; Reynolds, HA; Schaeffer, DJ; Tehseen, WM | 1 |
| Chao, CC; Chou, WY; Huang, YT; Lin-Chao, S; Ma, CM | 1 |
| MacPhail, HS; Skov, KA | 1 |
| Jarrell, JF; Sevcik, M; Stuart, G | 1 |
| Di Giulio, RT; Gallagher, EP; Hasspieler, BM | 1 |
| Chang, WC; Chen, SH; Jen, CJ; Lei, HY; Lin, MT; Tsao, CJ; Wing, LY; Wu, HL | 1 |
| Bigner, DD; Bullock, N; Colvin, OM; Friedman, HS; Griffith, OW; Kaufmann, SH; Ludeman, SM | 1 |
| Fantone, JC; Lucchesi, BR; Ventura, A; Werns, SW | 1 |
| Gemba, M; Kambara, K; Kawai, Y; Suzuki, A; Yamaguchi, T | 1 |
| Brännström, M; Clague, N; Janson, PO; Jarrell, JF; Sevcik, M; Stuart, G | 1 |
| Chan, HM; Cherian, MG; Tabarrok, R; Tamura, Y | 1 |
| Inoue, S; Ito, K; Kawanishi, S; Yamamoto, K | 1 |
| Applegate, LA; Frenk, E; Lautier, D; Tyrrell, RM | 1 |
| Gandolfi, AJ; Hall, PM; Lind, RC | 2 |
| Jenner, TJ; Maggi, A; O'Neill, P; Paone, A; Sapora, O | 1 |
| Guenthner, TM; Jevtović-Todorović, V | 1 |
| Burns, CP; Kelley, EE; Modest, EJ; Petersen, ES | 1 |
| Singh, SV; Xu, BH | 1 |
| Chen, CA; Collins, JL; Herzog, TJ; Mutch, DG | 1 |
| Lawrence, DA; Messina, JP | 2 |
| Mårtensson, J; Meister, A | 2 |
| Anderson, J; Smith, LJ | 1 |
| de Vries, EG; Meersma, GJ; Meijer, C; Mulder, NH; Sluiter, WJ; Timmer-Bosscha, H | 1 |
| Atzori, L; Cotgreave, I; Grafström, RC; Liu, Y | 1 |
| Cai, RM; Ding, L; Jin, XQ; Jin, YZ; Lu, WQ; Shen, ZF; Xu, JF; Xu, LM; Yang, JK | 1 |
| Ceccarelli, D; Gallesi, D; Masini, A; Sternieri, E; Trenti, T | 1 |
| Kitamoto, K; Nagasawa, T; Soejima, A; Suzuki, M; Waku, M | 1 |
| Busse, E; Kornhuber, B; Zimmer, G | 1 |
| Castonguay, A; Demkowicz-Dobrzanski, K | 1 |
| Caldwell, J; Marshall, AD | 1 |
| Lepinski, DL; Pellmar, TC; Roney, D | 1 |
| Alaoui-Jamali, MA; Batist, G; Centurioni, GM; Lehnert, S; Panasci, L; Schecter, R | 1 |
| Aebi, S; Lauterburg, BH | 1 |
| Barranco, SC; Greaves, BR; Perry, RR; Rasberry, U | 1 |
| Medzihradsky, JL; Wilson, JG | 1 |
| Bigner, DD; Brizel, DM; Friedman, HS; Griffith, OW; Halperin, EC; Honore, G; Sontag, MR | 1 |
| FitzGerald, GB; Prezioso, JA; Wick, MM | 1 |
| Franklin, MR; Galinsky, RE; Kimura, RE; Manning, BW | 1 |
| Magnusson, T; Pileblad, E | 4 |
| Hargrove, ME; Liang, CM; Liang, SM; Sharrow, SO; Ting, CC | 1 |
| Chan, PH; Kinouchi, H; Mizui, T | 1 |
| Kampinga, HH; Konings, AW; Peter, B; Wartena, M | 1 |
| Armstrong, DK; Colvin, OM; Davidson, NE; Gordon, GB; Hilton, J; Streeper, RT | 1 |
| Black, PH; Levy, EM; Salibian, M; Wu, J | 1 |
| Allalunis-Turner, MJ; Barron, GM; Day, RS; Dobler, K; Urtasun, RC | 1 |
| Britten, RA; Peacock, J; Warenius, HM; White, R | 1 |
| Richardson, ME; Siemann, DW | 1 |
| Durán, GE; Lau, DH; Lewis, AD; Sikic, BI | 1 |
| Bernhardt, G; Burgemeister, T; Gust, R; Keller, C; Mannschreck, A; Müller, R; Reile, H; Schönenberger, H; Spruss, T; vom Orde, HD | 1 |
| Das, SK; Fanburg, BL; White, AC | 1 |
| Bottje, WG; Graupner, WG; Maynard, PM | 1 |
| Bloomer, WD; Epperly, MW; Prezioso, JA; Wang, N | 1 |
| Allen, KG; Chao, PY | 1 |
| Allen, KG; Chao, PY; Kim, S | 1 |
| Begleiter, A; Israels, LG; Johnston, JB; Mowat, MR; Yang, WZ | 1 |
| Bellomo, G; Mirabelli, F; Orrenius, S; Richelmi, P; Stivala, L; Vairetti, M | 1 |
| Chan, HM; Cherian, MG | 1 |
| Auld, PA; Jain, A; Krauss, AN; Mårtensson, J; Mehta, T; Meister, A | 1 |
| Broquist, HP | 1 |
| Antoni, F; Garzó, T; Kalapos, MP; Mandl, J | 1 |
| Ito, K; Kawazoe, S; Mizutani, T; Yoshida, K | 1 |
| Calvin, HI; Fu, SC; Li, MY; Patel, SA; Zhang, JP | 1 |
| Calvin, HI; Fu, SC; Hess, JL; Patel, SA; von Hagen, S | 1 |
| Ito, K; Mizutani, T; Yoshida, K | 1 |
| Paller, MS; Patten, M | 1 |
| Perez, HD; Roll, FJ; Serhan, CN | 1 |
| Ceccarelli, D; Gallesi, D; Masini, A; Muscatello, U; Trenti, T | 1 |
| Lankhaar, G; Mulder, GJ; Polhuijs, M | 1 |
| Fruehauf, JP; Mimnaugh, EG; Sinha, BK | 1 |
| Bartsch, O; Busse, E; Kornhuber, B | 1 |
| Lewellyn, AL; Parchment, RE; Pierce, GB | 1 |
| Canada, AT; Romero, MJ | 1 |
| Basas, RA; Ling, CC; Wong, RS | 1 |
| Nakagawa, K | 2 |
| Bridges, RJ; Cotman, CW; Hatalski, CG; Koh, JY | 1 |
| Cammarata, PR; Tse, D; Yorio, T | 1 |
| Chaplin, DJ; Minchinton, AI | 1 |
| Campbell, EB; Griffith, OW; Hayward, ML | 1 |
| Enger, MD; Kang, YJ | 6 |
| Dahm, LJ; Roth, RA | 1 |
| de Vries, EG; Meijer, C; Mulder, NH; Peters, WH; Timmer-Bosscha, H | 1 |
| Bruno, NA; Rabier, MJ; Slate, DL | 1 |
| Bryan, CL; Duncan, CA; Jenkinson, SG; Komadina, KH | 1 |
| Auld, PA; Frayer, W; Jain, A; Mårtensson, J; Meister, A; Stole, E | 1 |
| Alvarez, MG; Bates, SE; Fojo, AT; Lai, GM; Moscow, JA | 1 |
| Arancibia, C; Campos, R; Garrido, A; Valenzuela, A | 1 |
| Sipes, IG; Weber, GL | 1 |
| Hamilos, DL; Mascali, JJ; Wedner, HJ | 1 |
| Cheeks, L; Green, K; Hull, DS; Pendarvis, RW | 1 |
| Falvey, D; Frenkel, GD; MacVicar, C | 1 |
| Brunmark, A; Ollinger, K | 1 |
| Boylan, LM; Spallholz, JE; Yan, L; Yee, JA | 1 |
| Ochi, T | 2 |
| Carper, SW; Gilligan, BJ; Hall, JS; Madsen, EL; Smith, FL; Storm, FK | 1 |
| Carp, N; Comis, RL; Hamilton, TC; LaCreta, FP; O'Dwyer, PJ; Ozols, RF; Padavic, K; Tew, KD; Young, RC | 1 |
| Bray, GP; Tredger, JM; Williams, R | 1 |
| Chong, MG; He, DE; Kelly, JH; Koussayer, T; Shang, TA; Sussman, NL; Whisennand, HH | 1 |
| Kuchan, MJ; Milner, JA | 1 |
| Ravindranath, V; Shivakumar, BR | 1 |
| Lautier, D; Luscher, P; Tyrrell, RM | 1 |
| Allalunis-Turner, MJ; Allen, PB; Aronyk, KE; Day, RS; Fulton, DS; Huyser-Wierenga, D; McKean, JD; Petruk, KC; Urtasun, RC; Weir, BK | 1 |
| Meadows, GG; Thrall, BD | 1 |
| Greig, NH; Rapoport, SI; Smith, QR; Takada, Y; Vistica, DT | 1 |
| Hiraishi, H; Ivey, KJ; Mutoh, H; Ota, S; Razandi, M; Sugimoto, T; Terano, A | 1 |
| Gipp, JJ; McClelland, RA; Mulcahy, RT | 1 |
| Hill, L; Lailey, AF; Lawston, IW; Stanton, D; Upshall, DG | 1 |
| Cammer, W; Tansey, FA | 1 |
| Costarides, AP; Green, K; Riley, MV | 2 |
| Malcolm, RR; Roberts, RJ; Spitz, DR; Sullivan, SJ | 1 |
| Barnhart-Bott, A; Green, MA | 1 |
| Meadows, GG; Raha, GA; Springer, DL; Thrall, BD | 1 |
| Elwell, JH; Harrison, DG; Mügge, A; Peterson, TE | 1 |
| Awasthi, YC; Gupta, V; Medh, RD | 1 |
| Hotta, T; Kawamoto, K; Kiya, K; Kurisu, K; Mikami, T; Nakada, Y; Saito, Y; Uozumi, T; Yamada, K | 1 |
| Fujiwara, C; Habuchi, O; Hisada, M; Kaigawa, S; Miyachi, T; Nakashima, S | 1 |
| Hoffer, LJ; Hum, S; Robitaille, L | 1 |
| Bachor, R; Hasan, T; Scholz, M; Shea, CR | 1 |
| Fujii, K; Kitahara, S; Ohtsu, A | 1 |
| Hill, BT; Hosking, LK; Shellard, SA | 1 |
| Corrales, F; Martin-Lomas, M; Mato, JM; Ochoa, P; Pajares, MA; Rivas, C | 1 |
| Hagiwara, K; Ichikawa, T; Kurokawa, Y; Naito, K | 1 |
| Mizutani, T; Nomura, H; Satoh, K | 1 |
| Brown, PI; Nicoll, DW; Rankin, GO; Teets, VJ | 2 |
| Buckley, BJ; Kent, RS; Whorton, AR | 1 |
| Standeven, AM; Wetterhahn, KE | 2 |
| Lash, LH; Woods, EB | 1 |
| Freeman, ML; Maines, MD; Meredith, MJ; Saunders, EL | 1 |
| Reed, DJ; Warren, DL | 2 |
| Brown, R; McLaughlin, K; McMahon, N; Stephens, I | 1 |
| Higuchi, Y; Matsukawa, S; Shoin, S | 1 |
| Dröge, W; Gmünder, H | 1 |
| Aw, TY; Jones, DP; Wierzbicka, G | 1 |
| Murray, DL; Rathbun, WB | 2 |
| Aidoo, A; Casciano, DA; Kodell, RL; Lyn-Cook, LE; Morris, SM | 1 |
| Emery, D; Enger, MD; Kang, YJ | 1 |
| Principe, P; Riley, PA; Slater, TF | 1 |
| Drieman, JC; Thijssen, HH | 1 |
| Mehendale, HM; Utley, WS | 1 |
| Brown, H; Hales, BF | 1 |
| Bier, H | 2 |
| Ansari, RA; Berndt, WO; Thakran, RS | 1 |
| Huang, HS; Jurima-Romet, M; Paul, CJ; Thomas, BH | 1 |
| Costarides, AP; Green, K; Nelson, E | 1 |
| Benchekroun, MN; Catroux, P; Montaudon, D; Robert, J | 1 |
| al-Kabban, M; Reglinski, J; Stewart, MJ; Watson, ID | 1 |
| Drieman, JC; Struyker-Boudier, HA; Thijssen, HH | 1 |
| Anderson, ME; Meister, A; Sharma, VK; Suthanthiran, M | 1 |
| Alken, PM; Forster, S; Koessig, J; Mickisch, GH; Roehrich, K; Tschada, RK | 1 |
| Hill, BT | 1 |
| Bellomo, G; Bertè, F; Colombo, P; Imberti, R; Mapelli, A; Richelmi, P | 1 |
| Bruno, M; Gamache, P; Hinson, JA; Khairallah, E; Klein, NW; Weeks, BS | 1 |
| Ford, JM; Hait, WN; Yang, JM | 1 |
| Bellamy, WT; Dalton, WS; Gleason, MC; Grogan, TM; Trent, JM | 1 |
| Lee, FY | 1 |
| Belzer, FO; Boudjema, K; Lindell, SL; Southard, JH | 1 |
| Djurhuus, R; Mansoor, MA; Svardal, AM; Ueland, PM | 1 |
| Batist, G; Greene, D; Lehnert, S; Schecter, R; Woo, A | 1 |
| Britten, RA; Broughton, C; Browning, PG; Green, JA; Warenius, HM; White, R | 1 |
| Frankfurt, OS; Seckinger, D; Sugarbaker, EV | 2 |
| Auld, PA; Jain, A; Mårtensson, J; Meister, A; Stole, E | 1 |
| Eisert, DR; Freeman, ML; Meredith, MJ; Saunders, EL | 1 |
| Benz, CC; Ford, JM; Hait, WN; Matlin, SA | 1 |
| Smyth, MJ | 1 |
| Acosta, D; Davila, JC; Davis, PJ | 2 |
| Connolly, AK; Powell, CJ | 1 |
| Harris, C; Juchau, MR; Mirkes, PE | 1 |
| Boyd, MR; Ravindranath, V | 1 |
| Jollow, DJ; Peters, RH; Stuart, RK | 1 |
| Fettman, MJ; Gould, DH; VanSteenhouse, JL | 1 |
| Broglio, TM; Calvin, HI; David, JC; Fu, SC; Hess, JL; Medvedovsky, C; Worgul, BV | 1 |
| Bigner, DD; Friedman, HS; Griffith, OW; McMahon, DP; Postels, DG; Skapek, SX; VanDellen, AF | 1 |
| Larsson, R; Nygren, P | 1 |
| Connor, MJ; Gange, RW; Hanada, K | 1 |
| Mizutani, T; Nakanishi, K; Nomura, H; Satoh, K | 1 |
| Drobitch, RK; Kloss, KA; Svensson, CK | 1 |
| Mãrtensson, J; Meister, A; Mrtensson, J | 1 |
| Ayala, A; Castaño, A; Gordillo, E; Lobato, MF; Machado, A | 1 |
| Hori, K; Kawakishi, S; Nakayama, T; Terazawa, K | 1 |
| Miyazaki, K; Nagafuchi, K | 1 |
| Hamilton, TC; O'Dwyer, PJ; Ozols, RF; Young, RC | 1 |
| Ahluwalia, GS; Cooney, DA; Grem, JL; Hao, Z | 1 |
| Cammarata, PR; Yorio, T | 1 |
| Magnusson, J; Ramel, C; Romert, L | 1 |
| Carlsson, B; Gustafsson, J; Larsson, A | 1 |
| Chen, G; Zeller, WJ | 1 |
| Franklin, MR; Manning, BW | 1 |
| Basas, RD; Ling, CC; Wong, RS | 1 |
| Bonner, FW; Eason, CT; Gartland, KP; Nicholson, JK | 1 |
| Jordan, SJ; Kennedy, CH; Maples, KR; Mason, RP | 1 |
| Dierickx, PJ | 1 |
| Brand, S; Forrester, T; Golden, M; Swales, J | 1 |
| Himeno, T; Kuriyama, H; Maeda, M; Neda, H; Niitsu, Y; Tsuji, Y; Watanabe, N; Yamauchi, N | 1 |
| Yeung, JH | 2 |
| Morita, S; Noda, T; Ohmori, M; Shimizu, M; Tsujimoto, Y; Yamada, A; Yamano, T | 1 |
| Bowman, BB; Hagen, TM; Jones, DP; Sillau, AH; Wierzbicka, GT | 1 |
| Fram, RJ; Robichaud, NJ | 1 |
| Ballard, K; Jollow, DJ; Oatis, JE; Peters, RH; Stuart, RK | 1 |
| Anderson, ME; Meister, A; Naganuma, A | 2 |
| Evans, PF; King, LJ; Parke, DV; Preece, NE | 1 |
| Armario, A; Garvey, JS; Hidalgo, J | 1 |
| Li, J; Murray, DL; Rathbun, WB | 1 |
| Gipp, JJ; McClelland, RA; Mulcahy, RT; Ublacker, GA | 1 |
| Griffith, OW; Reidenberg, MM; Wu, DF | 1 |
| Bigner, DD; Fekete, I; Friedman, HS; Griffith, OW; Groothuis, DR; Schlageter, KE | 1 |
| Jacobs, WR; Mandel, LJ; Schnellmann, RG | 1 |
| Aguilera, JA; Dethlefsen, LA; Fahey, RC; Loh, SN; Newton, GL | 1 |
| Djurhuus, R; Svardal, AM; Ueland, PM | 1 |
| Krishan, A; Nair, S; Samy, TS; Singh, SV | 1 |
| Beaujean, F; Goavec, M; Ito, H; Morizet, J; Rousseau, V; Stanislawski, M | 1 |
| Atsmon, J; Freeman, ML; Meredith, MJ; Roberts, LJ; Sweetman, BJ | 1 |
| Köberle, B; Speit, G | 1 |
| Bigner, DD; Colvin, OM; Friedman, HS; Griffith, OW; Halperin, EC; Honore, G; Lippitz, BE; Ostertag, CB | 1 |
| Kerem, D; Lalitha, T; Yannai, S | 1 |
| Jain, A; Mårtensson, J; Meister, A | 1 |
| He, XW; Osterloh, J | 1 |
| Kuntz, DJ; McGill, LD; Yost, GS | 1 |
| Boyce, HW; Chen, LT; Chen, MF; Ying, HS | 1 |
| Aisaka, K; Bossen, EH; Colvin, OM; Friedman, HS; Gross, SS; Hilton, J; Levi, R; Popp, J; Powell, JB; Reimer, KA | 1 |
| Atzori, L; Cotgreave, I; Dypbukt, JM; Edman, CC; Grafström, RC; Moldéus, P; Sundqvist, K | 1 |
| Mashiba, H; Matsunaga, K | 1 |
| Neuschwander-Tetri, BA; Roll, FJ | 1 |
| Ishikawa, M; Sasaki, K; Takayanagi, Y | 5 |
| Deguchi, T; Mataki, Y; Naya, M; Takahira, H; Yasuda, M | 1 |
| Michaelis, A; Rieger, R; Takehisa, S | 1 |
| Maines, MD; Mayer, RD | 1 |
| Nelson, SD; Slattery, JT; Thomassen, D | 1 |
| Hauser, GJ; McIntosh, JK; Rosenberg, SA; Travis, WD | 1 |
| Barranco, SC; Beasley, EG; Liu, NH; MacLean, KK; Schellenberg, K; Shaeffer, J; Townsend, CM; Weintraub, B | 1 |
| Ito, K; Mizutani, T; Nakanishi, K; Nomura, H | 1 |
| Du, DL; Grieshaber, CK; Murphy, MJ; Volpe, DA | 1 |
| Carlson, GP; Yang, CM | 1 |
| Hinder, RA; Oosthuizen, MM; Stein, HJ | 1 |
| Boelsterli, UA; Bouis, P | 1 |
| de Vries, EG; Hospers, GA; Meijer, C; Mulder, NH; Uges, DR | 1 |
| Mårtensson, J; Meister, A; Steinherz, R; Wellner, D | 1 |
| Bräunlich, H; Kretzschmar, M | 1 |
| DeGraff, W; Friedman, N; Mitchell, JB; Russo, A | 1 |
| Abe, M; Komuro, C; Nishidai, T; Ono, K; Shibamoto, Y; Takahashi, M; Tsutsui, K | 2 |
| Cederberg, H; Ramel, C | 1 |
| Cheeks, L; Green, K; Greiff, M | 1 |
| Costarides, A; Green, K; Recasens, JF; Riley, MV | 1 |
| Fornstedt, B; Magnusson, T; Pileblad, E | 1 |
| Hamilton, TC; Lai, GM; Ozols, RF; Young, RC | 1 |
| Cullen, MK; Kobb, SM; Miller, AM; Weiner, RS | 1 |
| Girotti, AW; Thomas, JP | 1 |
| Howes, AE; Kramer, RA; Montoya, VP; Soble, M | 1 |
| Albright, N; DeGraff, WG; Mitchell, JB; Phillips, TL; Rajpal, R; Russo, A | 1 |
| Dusre, L; Mimnaugh, EG; Myers, CE; Sinha, BK | 1 |
| Durand, RE; Olive, PL | 2 |
| Guo, SB; Manabe, S; Wada, O | 1 |
| Anderson, ME; Kimura, A; Meister, A; Moore, WR; Murata, K | 1 |
| Brötell, H; Karg, E; Rorsman, H; Rosengren, E | 1 |
| Cherian, MG; Gallant, KR | 1 |
| Astor, MB; Baker, MA; Bhalla, K; Gervasoni, JE; Hindenburg, AA; Krishna, S; Lutzky, J; Rosado, M; Stewart, V; Taub, RN | 1 |
| Anderson, ME; Bridges, RJ; Meister, A; Underwood, M | 1 |
| Kera, Y; Komura, S; Ohbora, Y | 1 |
| Aldunate, J; Letelier, ME; Moncada, C; Morello, A; Repetto, Y | 1 |
| Elias, MM; Rodriguez, JV; Torres, AM | 1 |
| Bigner, DD; Bigner, SH; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Horton, JK; Lilley, E; Rosenberg, MC | 1 |
| Principe, P; Riley, PA; Slater, TF; Wilson, GD | 1 |
| Inaba, M; Iwata, K; Kubodera, A; Ozawa, S | 1 |
| Cockett, AT; Lee, KE; Mayer, RD | 3 |
| Clapper, JA; Enger, MD; Kang, YJ | 1 |
| Buckpitt, A; Buonarati, M; Morin, D; Plopper, C | 1 |
| Duddy, SK; Hsia, MT | 1 |
| Goldfarb, RD; Lee, CY; Lee, KJ; Singh, A; Tsan, MF | 1 |
| Cerutti, PA; Ochi, T | 1 |
| Ardiet, C; Navarro, C; Sapet, C; Tranchand, B | 1 |
| Den Boer, PJ; Grootegoed, JA; Mackenbach, P | 1 |
| DeHart, PD; Nadeau, DM; Simon, RH | 1 |
| Coshan-Gauthier, RK; Kirkpatrick, DL | 1 |
| Bekkedal, K; Brunborg, G; Dybing, E; Holme, JA; Nelson, SD; Omichinski, JG; Søderlund, EJ; Trygg, B | 1 |
| Chou, IN; Leung, MF | 1 |
| Cook, JA; DeGraff, W; Glatstein, E; Mitchell, JB; Russo, A | 1 |
| Evans, WK; Stewart, DJ | 1 |
| Hettiaratchi, P; Koch, CJ; Stobbe, CC | 1 |
| Favier, D; Kable, EP; Parsons, PG | 1 |
| Evans, PC; Hardy, JR; Paxton, JW | 1 |
| Rosano, CL; Tsan, MF; White, JE | 1 |
| Linder, RE; Perreault, SD; Slott, VL; Strader, LF | 1 |
| Beuter, W; Cojocel, C; Mayer, D; Müller, W | 1 |
| Hodgkiss, RJ; Stratford, MR; Watfa, RR | 1 |
| Biaglow, JE; Clark, EP; Epp, ER; Held, KD; Tuttle, SW; Varnes, ME | 1 |
| McNally, NJ; Soranson, JA | 1 |
| Flaherty, AA; Penney, DP; Siemann, DW | 1 |
| Abarzua, M; Davis, JA; Kiani, T; Weinberg, JM | 1 |
| Cherian, MG; Suzuki, CA | 1 |
| Li, LY; Meister, A; Risley, MS; Seddon, AP | 1 |
| Bartels, L; Riemann, D; Siegers, CP | 1 |
| Gipp, JJ; McClelland, RA; Mulcahy, RT; Panicucci, R; Ublacker, GA | 1 |
| Dikdan, G; Dimaira, MJ; Hu, JJ; Lea, MA; Zirvi, KA | 1 |
| Frayer, W; Jain, A; Mårtensson, J; Meister, A | 1 |
| Konings, AW; Lemstra, W; Malingré, TM; Woerdenbag, HJ | 1 |
| Honda, S; Matsuo, M | 2 |
| Grieshaber, CK; Liao, JT; Page, JG; Smith, AC; Wientjes, MG | 1 |
| Helston, LM; Wells, PG; Wong, M | 1 |
| Asai, K; Funaki, C; Hayashi, T; Kuzuya, F; Kuzuya, M; Naito, M | 1 |
| Cattell, D; Lee, N; Liang, CM; Liang, SM | 1 |
| Goavec, M; Ito, H; Rousseau, V; Stanislawski, M | 1 |
| Jain, A; Mårtensson, J; Meister, A; Steinherz, R | 1 |
| Morganroth, ML; Peters-Golden, M; Shelly, C | 1 |
| Nederbragt, H | 1 |
| Leyland-Jones, B | 1 |
| Javor, B; Newton, GL | 1 |
| Curthoys, NP; Rankin, BB; Wells, W | 1 |
| Benson, JM; Henderson, RF; Ragsdale, SS; Sun, JD | 1 |
| Bonanni, LC; Divo, AA; Geary, TG; Jensen, JB | 1 |
| Allen, RG; Farmer, KJ; Newton, RK; Sohal, RS; Toy, PL | 1 |
| Abbott, WA; Meister, A | 1 |
| Devoto, MA; Puente, J; Sapag-Hagar, M | 1 |
| Inoue, M; Morino, Y; Shinozuka, S | 1 |
| Hales, BF; Slott, VL | 2 |
| Bodell, WJ; Doane-Setzer, P; Evans, CG; Smith, MT; Tokuda, K | 1 |
| Curthoys, NP; Scott, RD | 1 |
| Anderson, ME; Meister, A; Singhal, RK | 1 |
| Bishop, JB; Harbison, RD; Teaf, CM | 1 |
| Huang, CS; Meister, A; Moore, WR | 1 |
| Hahn, FF; Harkema, JR; Henderson, RF; McLaughlin, SI; Pickrell, JA; Sun, JD | 1 |
| Michiels, C; Remacle, J | 1 |
| McCartney, MA | 1 |
| Ballatori, N; Truong, AT | 1 |
| Freeman, ML; Meredith, MJ | 1 |
| Masukawa, T; Sai, M; Tochino, Y | 1 |
| Bigner, DD; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Hilton, J; Lippitz, B; Schold, SC | 1 |
| Aza, MJ; Collado, PS; Esteller, A; González, J; Lasierra, J | 1 |
| Bellamy, WT; Dalton, WS; Dorr, RT; Meltzer, P | 1 |
| Astor, MB; Biaglow, JE; Clark, EP; Epp, ER; Hall, EJ; Roizen-Towle, L; Varnes, ME | 1 |
| Dobson, PP; Fornace, AJ; Kinsella, TJ; Mitchell, JB; Russo, A | 1 |
| Biaglow, JE; Clark, EP; Donahue, LL; Epp, ER; Tuttle, SW; Varnes, ME | 1 |
| Biscay, P; Guichard, M; Lespinasse, F; Malaise, EP | 1 |
| Dean, RT; Vince, GS | 1 |
| Frankfurt, OS | 2 |
| Henle, KJ; Moss, AJ; Nagle, WA | 1 |
| Almagor, M; Gilon, C; Kahane, I; Yatziv, S | 1 |
| Ono, K; Shrieve, DC | 2 |
| Henderson, BW; Miller, AC | 2 |
| Deeg, HJ; Luk, K; Shulman, HM; Shuman, WB; Storb, R | 1 |
| Corcoran, GB; Wong, BK | 1 |
| Deen, DF; Hunter, KJ; Marton, LJ | 1 |
| Eaton, DL; Monroe, DH | 1 |
| Roizin-Towle, L | 1 |
| DeGraff, WG; Mitchell, JB | 1 |
| Falvey, D; Frenkel, GD | 1 |
| Hamilton, TC; Ozols, RF; Young, RC | 2 |
| Gescher, A; Harpur, ES; Lazenby, CM; Lee, SJ | 1 |
| Leith, JT | 1 |
| Sultatos, LG; Woods, L | 1 |
| Cieslinski, DA; Humes, HD; Messana, JM; O'Connor, RP | 1 |
| Gattone, VH; Grotyohann, LW; Martin, LF; Scaduto, RC; Wertz, J | 1 |
| Freeman, ML; Laszlo, A; Meredith, MJ | 1 |
| Timbrell, JA; Tulip, K | 1 |
| Bigner, DD; Colapinto, EV; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Groothuis, DR; Hilton, J; Lee, Y; Skapek, SX | 1 |
| Hassan, AS | 2 |
| Cihla, HP; Coursin, DB | 1 |
| Duncan, DD; Lawrence, DA | 1 |
| Kato, Y; Kimura, R; Kogure, T; Sato, M | 1 |
| Ishikawa, M; Sasaki, K; Takayanagi, G | 1 |
| Nakagawa, Y; Tayama, K | 1 |
| Roos-Verhey, WS; Vos, O | 1 |
| Cory, JG; Weckbecker, G | 1 |
| Barbee, RR; Perreault, SD; Slott, VL | 1 |
| Edgren, M; Ehrsson, H; Hansson, J; Nilsson, B; Ringborg, U | 1 |
| Ochi, T; Ohsawa, M; Otsuka, F; Takahashi, K | 1 |
| Andrews, PA; Howell, SB; Murphy, MP; Schiefer, MA | 1 |
| Carmichael, J; DeGraff, W; Friedman, N; Gamson, J; Glatstein, E; Mitchell, JB; Russo, A | 1 |
| Lee, FY; Siemann, DW; Vessey, AR | 1 |
| Biaglow, JE; Donahue, LL; Friedman, LR; Oleinick, NL; Xue, LY | 1 |
| Bhatt, HS; Combes, B; Lober, SB | 1 |
| Bigner, DD; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Skapek, SX | 1 |
| Calvin, HI; Cohen, G; Slivka, A; Spina, MB | 1 |
| Bill, CA; Gescher, A; Hickman, JA | 1 |
| Biaglow, JE; Dethlefsen, LA; Lehman, CM; Peck, VM | 1 |
| Arundel, CM; Bliven, SF; Hallows, KT; Leith, JT | 1 |
| Allalunis-Turner, MJ; Keng, PC; Lee, FY; Siemann, DW | 1 |
| Edwards, PG | 1 |
| Bauer, JA; Corcoran, GB; Lau, TW | 1 |
| Buchet, JP; Lauwerys, R | 1 |
| Reed, DJ; Tirmenstein, MA | 1 |
| Crook, TR; McLean, AE; Souhami, RL; Whyman, GD | 1 |
| Kessel, D; Romine, MT | 1 |
| Roos-Verheij, WS; van der Schans, GP; Vos, O | 1 |
| Anderstam, B; Harms-Ringdahl, M | 1 |
| Lohman, PH; Roos-Verheij, WS; van der Schans, GP; Vos, O | 1 |
| Jones, K; Perry, TL; Wright, JM; Yong, VW | 1 |
| Bellamy, AS; Hill, BT; Lock, RB; Whelan, RD | 1 |
| Hodgkiss, RJ; Roberts, IJ; Watts, ME; Woodcock, M | 1 |
| Eklöw-Låstbom, L; Orrenius, S; Rossi, L; Thor, H | 1 |
| Carmichael, J; DeGraff, W; Friedman, N; Glatstein, E; Mitchell, JB; Russo, A; Tochner, Z | 1 |
| Glatstein, E; Kinsella, TJ; Mitchell, JB; Russo, A | 1 |
| Freeman, JJ; Hayes, EP | 1 |
| Duff, R; Murrill, E | 1 |
| Jensen, DE; Magee, PN; Tacchi, AM | 1 |
| Chidiac, P; Goldberg, MT | 1 |
| Dorr, RT | 1 |
| Dorr, RT; Liddil, JD; Soble, MJ | 1 |
| Lobreau, AU; Szekely, JG | 1 |
| Fariss, MW; Olafsdottir, K; Pascoe, GA; Reed, DJ | 1 |
| Fidelus, RK; Ginouves, P; Lawrence, D; Tsan, MF | 1 |
| Kirkpatrick, DL | 1 |
| Nakagawa, Y | 1 |
| Cohen, GM; d'Arcy Doherty, M; Jordan, J | 1 |
| Allalunis-Turner, MJ; Lee, FY; Siemann, DW | 1 |
| Edgren, M; Révész, L | 3 |
| Fricke, RF; Goon, DJ; Nagasawa, HT; Roberts, JC; Zera, RT | 1 |
| Broome, JD; Chen, PC; Gaetjens, E | 1 |
| Adams, SP; Notides, AC | 1 |
| Baggett, JM; Berndt, WO | 1 |
| Mandel, LJ; Schnellmann, RG | 1 |
| Calvin, HI; Medvedovsky, C; Worgul, BV | 1 |
| Stearns, ME; Tew, KD; Woodworth, A | 1 |
| Fidelus, RK; Tsan, MF | 1 |
| Astor, MB | 1 |
| Biaglow, JE; Clark, EP; Dethlefsen, LA; Epp, ER; Glazier, K; Oleinick, NL; Tuttle, SW; Varnes, ME | 1 |
| Edgren, MR; Révész, L; Sölen, G | 1 |
| Baer, KA; Koch, CJ; Stobbe, CC | 1 |
| Biaglow, JE; Dethlefsen, LA; Peck, VM; Ridinger, DN | 1 |
| Harris, JW; Shrieve, DC | 1 |
| Geard, CR; Georgsson, MA | 1 |
| Carmichael, J; DeGraff, W; Fisher, J; Friedman, N; Mitchell, JB; Phillips, T; Russo, A; Tochner, Z | 1 |
| Adams, DJ; Carmichael, J; Friedman, N; Mitchell, JB; Russo, A; Tochner, Z; Wolf, CR | 1 |
| Bertsche, U; Schorn, H | 1 |
| Ballatori, N; Boyer, JL | 1 |
| Bus, JS; Chellman, GJ; Norton, RM; White, RD | 1 |
| Costa, LG; Murphy, SD | 1 |
| Hunt, DF; Steffens, JC; Williams, BG | 1 |
| Chou, IN; Shaw, JP | 1 |
| Bump, EA; Kovacs, M; Lee, W; Rice, GC; Shrieve, DC | 1 |
| Alexander, J; Harris, AL; Hickson, ID; Robson, CN | 1 |
| Fantel, AG; Harris, C; Juchau, MR | 1 |
| Brown, LA; Hagen, TM; Jones, DP | 1 |
| Biaglow, JE; Clark, EP; Epp, ER; Morse-Gaudio, M | 1 |
| Fujita, S; Mizutani, T; Nakanishi, K; Nomura, H | 1 |
| Behrens, BC; Dykes, D; Fine, RL; Hamilton, TC; Louie, KG; Ozols, RF; Plowman, J | 1 |
| Abe, M; Komuro, C; Nishidai, T; Ono, K; Shibamoto, Y; Shrieve, DC; Takahashi, M; Tsutsui, K | 1 |
| Andrews, PA; Burns, CP; Hromas, RA; Murphy, MP | 1 |
| Foote, SE; Paxton, JW; Singh, RM | 1 |
| Lewko, WM | 1 |
| Amouyal, G; Degott, C; Descatoire, V; Geneve, J; Larrey, D; Letteron, P; Pessayre, D; Tinel, M | 1 |
| Ahmad, S; Greene, K; Kramer, RA; Vistica, DT | 1 |
| Dorr, RT; Soble, MJ | 1 |
| Astor, M; Tomashefsky, P; White, RD | 1 |
| Griffith, OW; Meister, A | 1 |
| Edgren, M; Nishidai, T; Révész, L; Scott, OC | 1 |
| Konings, AW; Penninga, P | 1 |
| Darrow, RM; Morgan, MS; Nafz, MA; Varandani, PT | 1 |
| Barke, R; Harty, JT; Humphrey, E; Keller, GA; Simmons, RL | 1 |
| Galinsky, RE | 1 |
| Cordeiro, RF; Savarese, TM | 1 |
| Harris, C; Thurman, RG | 1 |
| Guichard, M; Lespinasse, F; Malaise, EP | 1 |
| Egle, PM; Shelton, KR; Todd, JM | 1 |
| Scott, OC | 1 |
| Astromoff, A; Harris, JW; Li, GC; Shrieve, DC | 1 |
| Aw, TY; Kaplowitz, N; Ookhtens, M; Ren, C | 1 |
| Freeman, ML; Malcolm, AW; Meredith, MJ | 1 |
| Brodie, AE; Reed, DJ | 1 |
| Danis, EH; Del Vecchio, PJ; Rosano, CL; Tsan, MF | 1 |
| Behrens, BC; Grotzinger, KR; Hamilton, TC; Kinsella, TJ; Louie, KG; McKoy, WM; Ozols, RF; Winker, MA | 1 |
| Chen, CW; Cohen, JS; Knop, RH; McPherson, S; Mitchell, JB; Russo, A | 1 |
| Hodgkiss, RJ; Middleton, RW | 2 |
| Bond, JA; McClellan, RO; Medinsky, MA; Shelton, H | 1 |
| Boyd, MR; Kramer, RA; Schuller, HM; Smith, AC | 1 |
| Romero, FJ; Sáez, GT; Viña, J | 1 |
| Hamilos, DL; Wedner, HJ | 1 |
| Batist, G; Behrens, BC; Grotzinger, KR; Hamilton, TC; Louie, KG; McKoy, WM; Ozols, RF; Tsuruo, T; Winker, MA; Young, RC | 1 |
| Andrews, PA; Howell, SB; Murphy, MP | 1 |
| Denekamp, J; Minchinton, AI; Shrieve, DC | 1 |
| Griffith, KL; Hue, DP; McLean, AE | 1 |
| Brooks, CG; Davis, WC; Ristow, SS; Stanford, DR; Starkey, JR | 1 |
| Earnshaw, BA; Johnson, MA | 1 |
| Hill, TD; Radha, E; Rao, GH; White, JG | 1 |
| Mitchell, JB; Russo, A | 3 |
| Durand, RE | 1 |
| Griffith, OW | 4 |
| Cohn, ZA; Griffith, OW; Hamill, AL; Rouzer, CA; Scott, WA | 1 |
| Jensen, GL; Meister, A | 1 |
| Clavier, RM; Foulks, JG; Godin, DV; Ito, M; Perry, TL; Wall, RA; Yong, VW | 1 |
| Drew, R; Miners, JO | 1 |
| Berggren, M; Dawson, J; Moldéus, P | 1 |
| Friedman, N; McPherson, S; Mitchell, JB; Russo, A | 1 |
| Adams, GE | 1 |
| Brown, JM; Yu, NY | 1 |
| Hodgkiss, RJ; Jones, NR; Watts, ME; Woodcock, M | 1 |
| Bonkovsky, HL; Shedlofsky, SI; Sinclair, JF; Sinclair, PR | 1 |
| Palcic, B | 1 |
| Loretz, LJ; Pariza, MW | 1 |
| Astor, M; Biaglow, JE; Clark, EP; Epp, ER; Varnes, ME | 1 |
| Biaglow, JE; Hall, EJ; Roizin-Towle, L; Varnes, ME | 1 |
| Astor, MB; Biaglow, JE; Hall, EJ; Hartog, B | 1 |
| Roos-Verhey, WS; van der Schans, GP; Vos, O | 1 |
| Geard, CR; Hall, EJ; Hei, TK | 1 |
| Bremner, JC; Jones, NR; Minchinton, AI; Rojas, A; Shrieve, DC; Smith, KA; Soranson, JA | 1 |
| Biaglow, JE; Costello, T; Hall, EJ; Roizin-Towle, L; Varnes, ME | 1 |
| Bus, JS; Norton, R; White, RD | 1 |
| Broome, JD; Chen, P; Gaetjens, EC | 1 |
| Romero, FJ; Sies, H | 1 |
| Birkett, DJ; Drew, R; Miners, JO | 1 |
| Green, JA; Hamilton, TC; Ozols, RF; Rogan, AM; Vistica, DT; Young, RC | 1 |
| Abe, M; Edgren, M; Nishidai, T; Ono, K; Révész, L; Takahashi, M | 1 |
| Denekamp, J; Middleton, RW; Minchinton, AI; Rojas, A; Smith, KA; Soranson, JA | 1 |
| Mizutani, T; Nomura, H; Tajima, K; Yamamoto, K | 1 |
| Biaglow, JE; Clark, EP; Epp, ER; Morse-Gaudio, M; Zachgo, E | 1 |
| Meister, A; Puri, RN | 1 |
| Brezis, M; Epstein, FH; Rosen, S; Silva, P | 1 |
| Biaglow, JE; McPherson, S; Mitchell, JB; Russo, A | 1 |
| Biaglow, JE; Clark, EP; Epp, ER; Varnes, ME | 1 |
| Somfai-Relle, S; Suzukake, K; Vistica, BP; Vistica, DT | 1 |
| Callahan, KS; Harker, LA; Harlan, JM; Levine, JD; Schwartz, BR | 1 |
| David, LL; Shearer, TR | 1 |
| McPherson, S; Mitchell, JB; Russo, A | 1 |
| Arrick, BA; Cohn, ZA; Griffith, OW; Nathan, CF | 1 |
| Dethmers, JK; Meister, A | 1 |
| Arrick, BA; Cerami, A; Griffith, OW | 1 |
| Lawrence, DA; Palace, GP | 1 |
| Ciriolo, MR; Coppola, S; Ghibelli, L; Lafavia, E; Maresca, V; Rotilio, G | 1 |
| Jean, PA; Roth, RA | 1 |
| Baruchel, S; Batist, G; Farah, R; Jamali, M; Wang, T | 1 |
| Panda, BB; Subhadra, AV | 1 |
| Lafuente, A; Li, Y; Trush, MA | 1 |
| Ferrell, LD; Grendell, JH; Lüthen, RE; Neuschwander-Tetri, BA; Niederau, C | 1 |
| Li, Y; Trush, MA; Zhu, H | 1 |
| Fujihara, Y; Iguchi, S; Kaneo, Y; Ogawa, K; Tanaka, T | 1 |
| Kavanagh, TJ; Poot, M; Rabinovitch, PS; Teubert, H | 1 |
| Buchmüller-Rouiller, Y; Corrandin, SB; Jongeneel, CV; Mauël, J; Ransijn, A; Schneider, P; Smith, J | 1 |
| Burt, ME; Hochwald, SN; Port, JL; Wang, HY | 1 |
| Boustani, MR; Fanburg, BL; Hassoun, PM; Maloney, EK; White, AC | 1 |
| Hwang, J; Lai, SL; Perng, RP; Whang-Peng, J | 1 |
| Brennan, J; Gallo, JM; Halbherr, T; Hamilton, TC; Laub, PB; O'Dwyer, PJ; Ozols, RF | 1 |
| Berglund, T; Komlos, P; Ohlsson, AB; Rydström, J | 1 |
| Panda, BB; Patra, J; Subhadra, AV | 1 |
| Lamar, PC; Prozialeck, WC | 1 |
| Arai, M; Boku, Y; Hirata, I; Kokura, S; Kondo, M; Nakagawa, S; Yoshikawa, T | 1 |
| Estrela, JM; Lasso De la Vega, MC; Navarro, J; Obrador, E; Pellicer, JA | 1 |
| Kuroiwa, Y; Oguro, T; Sasaki, M; Sato, M; Yoshida, T | 1 |
| Hasegawa, R; Kurokawa, Y; Sai-Kato, K; Takagi, A; Tanimura, A; Umemura, T | 1 |
| Kinter, MT; Roberts, RJ; Spitz, DR | 1 |
| Eady, JJ; Orta, T; Peacock, JH; Steel, GG | 1 |
| Hedley, DW; Nicklee, T; Thomas, M | 1 |
| Bagrij, T; Broxterman, HJ; Scheper, RJ; Twentyman, PR; Versantvoort, CH | 1 |
| Andrews, JE; Ebron-McCoy, MT; Kavlock, RJ; Nichols, HP | 1 |
| Contreras, R; Ott, S; Reyes, E; Robinson, B | 1 |
| Batres, L; Carrizales, L; Díaz-Barriga, F; Mejía, J; Ortíz, D; Ramos, O; Yáñez, L | 1 |
| Anzon, E; Bernelli-Zazzera, A; Pogliaghi, G; Radice, L; Tacchini, L | 1 |
| Broxterman, HJ; Feller, N; Pinedo, HM; Währer, DC | 1 |
| Devaraj, H; Raveendran, M; Thanislass, J | 1 |
| Aréchiga, CF; Ealy, AD; Hansen, PJ | 1 |
| Brooks, SE; Dupuis, NP; Holden, SA; Korbut, TT; Teicher, BA | 1 |
| Coutts, C; Graves, RJ; Green, T | 1 |
| Alexandre, E; Boudjema, K; Chenard, MP; Cinqualbre, J; Imbs, P; Jaeck, D; Nakano, H; Wolf, P | 1 |
| Gardiner, CS; Reed, DJ | 2 |
| Hamilton, TC; O'Dwyer, PJ; Ozols, RF; Tew, KD; Yao, KS | 1 |
| Cowan, KH; Kohno, K; Kuwano, M; Morrow, CS; Ono, M; Wada, M; Yokomizo, A | 1 |
| Baas, F; Beijnen, J; Borst, P; Dekker, H; Lankelma, J; Oude Elferink, RP; Paulusma, C; van Tellingen, O; Zaman, GJ | 1 |
| Lawrence, DA; Malossi, JA; Michaud, SG; Walsh, AC | 1 |
| Nohl, H; Stolze, K; Weiner, LM | 1 |
| Lawrence, DA; Walsh, AC | 1 |
| Davydov, MI; Donenko, FV; Kabieva, AO; Machaladze, ZO; Moroz, LV; Polotskiĭ, BE; Sitdikova, SM | 1 |
| Donaldson, K; Li, XY; Macnee, W; Rahman, I | 2 |
| Graham, A; Wood, JL | 1 |
| Denekamp, J; Johns, H; Joiner, B; Joiner, M; Stevens, G | 1 |
| Lander, HM; Novogrodsky, A; Ogiste, JS; Teng, KK | 1 |
| Abraham, SK; Kesavan, PC; Singh, SP | 1 |
| Bootman, MD; Casteels, R; De Smedt, H; Droogmans, G; Missiaen, L; Parys, JB | 1 |
| Gemma, S; Sbraccia, M; Testai, E; Vittozzi, L | 1 |
| Kinter, MT; Roberts, RJ; Spitz, DR; Walker, MW | 1 |
| Favilli, F; Ferretti, P; Iantomasi, T; Marraccini, P; Tonelli, F; Vincenzini, MT | 1 |
| Cowan, KH; Schneider, E; Sinha, BK; Yamazaki, H | 1 |
| Irie, Y; Mizutani, T; Nakanishi, K | 1 |
| Allenbacher, A; Botzler, C; Issels, RD; Meier, T; Multhoff, G; Wiesnet, M; Wilmanns, W | 1 |
| Bohets, HH; D'Haese, PC; De Broe, ME; Dierickx, PJ; Nouwen, EJ; Van der Biest, I; Van Landeghem, GF; Van Thielen, MN | 1 |
| Cotgreave, IA; Hu, J | 1 |
| Malorni, W; Matarrese, P; Rivabene, R | 1 |
| Backes, MG; Blanock, K; Emerson, EO; Jani, JP; Rihn, C; Scalamogna, D; Singh, SV; Specht, S; Stemmler, N; Xu, BH | 1 |
| Mulder, GJ; Pang, KS; Snel, CA | 1 |
| Bates, TE; Clark, JB; Davies, SE; Heales, SJ | 1 |
| Kim, CY; Satoh, H; Watanabe, C | 1 |
| Heintz, NH; Janssen, YM; Mossman, BT | 1 |
| Maitra, I; Packer, L; Serbinova, E; Trischler, H | 1 |
| Belov, L; Davey, MW; Davey, RA; Hancox, D; Harvie, RM; Longhurst, TJ; Wheeler, H | 1 |
| André, P; Chevy, F; Driss, F; Dubertret, L; Mazière, C; Mazière, JC; Quiec, D; Redziniak, G; Santus, R; Wolf, C | 1 |
| Andrejuk, T; Dziuban, SW; Goldfarb, RD; Lee, KJ | 1 |
| Andersen, CR; Cobbett, CS; Goldsbrough, PB; Howden, R | 1 |
| Adrian, TE; Bagchi, D; Hinder, RA; Kretchmar, DH; Perdikis, G; Redmond, EJ; Stinson, RG; Wetscher, GJ | 1 |
| Kuntz-Simon, G; Obert, G | 1 |
| Awad, JA; Burk, RF; Hill, KE; Lyons, PR; Morrow, JD | 1 |
| Chen, G; Waxman, DJ | 2 |
| Craig, RB; Harris, AL; Hickson, ID; Walker, LJ | 1 |
| Herzenberg, LA; Raju, PA; Roederer, M | 1 |
| Hagiwara, K; Ichikawa, T; Ota, K; Ozasa, H | 1 |
| Davey, MW; Davey, RA; Kidman, AD; Su, GM | 1 |
| Packer, L | 1 |
| Huxtable, RJ; Yan, CC | 1 |
| Doan, TN; Elliott, SJ; Henschke, PN | 1 |
| Graham, A; O'Leary, VJ; Stone, D; Wood, JL | 1 |
| Grattagliano, I; Lauterburg, BH; Schranz, C; Wieland, P | 1 |
| Buttin, G; De Saint Vincent, BR; Lunel-Orsini, C | 2 |
| Calvin, HI; David, LL; Fu, SC | 1 |
| Borsellino, N; Crescimanno, M; D'Alessandro, N; Flandina, C; Flugy, A; Leonardi, V; Rausa, L | 1 |
| Ji, LL; Leeuwenburgh, C | 1 |
| Atalay, M; Hänninen, O; Sen, CK | 1 |
| Abe, M; Hara, M; Orhii, PB; Poeggeler, B; Reiter, RJ | 1 |
| Chatterjee, A; Chattopadhyay, A; Lawlor, CJ | 1 |
| Aschner, M; Kimelberg, HK; Lash, LH; Mullaney, KJ; Wagoner, D | 1 |
| Pan, Z; Perez-Polo, R | 1 |
| del Marmol, V; Ghanem, G; Huez, G; Lejeune, F; Libert, A; Sels, A; Solano, F | 1 |
| Borroz, KI; Davis, MA; Eaton, D; Jeffery, EH; Wallig, MA | 1 |
| Ishita, S; Kato, S; Mawatari, K; Sugawara, K | 1 |
| Andrade, F; Anzueto, A; Brassard, J; Jenkinson, SG; Lawrence, RA; Levine, SM; Maxwell, LC; Morales, CF | 1 |
| Ban, M; Hettich, D; Huguet, N | 1 |
| Harada, T; Hiraishi, H; Ivey, KJ; Mutoh, H; Ota, S; Razandi, M; Sugimoto, T; Terano, A | 1 |
| Borroz, KI; Buetler, TM; Eaton, DL | 1 |
| Bump, EA; Coleman, CN; Griffith, OW; Hurwitz, SJ; Lai, LL; Malaker, K; Riese, N | 1 |
| Brunk, UT; Gao, G; Ollinger, K | 1 |
| Cotgreave, IA; Schuppe-Koistinen, I | 1 |
| Chang, CC; Chang, LS | 1 |
| Prezioso, JA; Rosenstein, M; Shields, D; Wang, N | 1 |
| Awad, JA; Burk, RF; Roberts, LJ | 1 |
| Beketić-Oresković, L; Jaksić, M; Osmak, M | 1 |
| Cordier, A; Diez-Fernandez, C; Prieto, P; Trendelenburg, CF; Wolf, A | 1 |
| Hori, K; Ishii, K; Katayama, M; Sato, N; Waga, S; Yodoi, J | 1 |
| Feng, Y; Hatcher, EL; Kang, YJ | 1 |
| Satriano, J; Schlondorff, D; Shan, Z; Silbiger, S; Tan, D | 1 |
| Barr, SG; Harrison, JJ; Racz, WJ; Rafeiro, E | 1 |
| Battles, AH; Lee, JJ | 1 |
| Costa, M; Gao, M; Huang, X; Salnikow, K; Voitkun, V | 1 |
| Cabello Porras, MR; Cantoni, L; Carelli, M; Rizzardini, M | 1 |
| Alcedo, JA; Misra, M; Wetterhahn, KE | 1 |
| Chen, HL; Liao, TS; Lin, WM; Liu, CL; Sun, KH; Tsai, CY; Yu, CL; Yu, HS | 1 |
| Chow, S; Hedley, DW | 1 |
| Baraban, JM; Murphy, TH; Ratan, RR | 1 |
| Averill-Bates, DA; Przybytkowski, E | 2 |
| Berger, NA; Berger, SJ; Gosky, D; Willson, JK; Zborowska, E | 1 |
| Hiramatsu, H; Hirata, J; Ishii, K; Kikuchi, Y; Kita, T; Kudoh, K; Nagata, I | 1 |
| Aloui-Jamali, MA; Batist, G; Lehnert, S; Vestergaard, J | 1 |
| Kang, YJ | 3 |
| Edgren, MR; Imamura, M | 1 |
| Fontán, A; Masuh, H; Picollo, MI; Zerba, E | 1 |
| Chaudhry, FA; Hjelle, OP; Ottersen, OP | 1 |
| Foster, JR; Green, T; Smith, LL; Tittensor, S; Wyatt, I | 1 |
| Dorr, RT; Lagel, K | 1 |
| Chain, BM; Foreman, JC; Vint, IA | 2 |
| Hamazaki, S; Minamiyama, Y; Okada, S; Sotomatsu, A; Toyokuni, S | 1 |
| Bauer, KD; Dordal, MS; Pierre-Jerome, M; Raghu, G; Simonian, P; Winter, JN | 1 |
| al-Nabulsi, I; Belldegrun, A; Friedman, N; Kasid, U; Leung, SW; Mitchell, JB; Newsome, J | 1 |
| Kesavan, PC; Singh, SP | 1 |
| Cook, JA; Hahn, SM; Kaufman, DC; Liebmann, JE; Lipschultz, C; Mitchell, JB | 1 |
| Leeder, JS; Riley, RJ; Spielberg, SP | 1 |
| Godwin, AK; Hamilton, TC; O'Dwyer, PJ; Ozols, RF; Yao, K | 1 |
| Osmak, M | 1 |
| Cuccurullo, F; D'Orazio, A; Di Febbo, C; Martelli, N; Mezzetti, A; Pandolfi, A; Poggi, A; Porreca, E | 1 |
| Hollaar, L; Le, CT; van der Laarse, A; van der Valk, EJ | 1 |
| Ali-Osman, F; Sriram, R | 1 |
| Brennan, JM; LaCreta, FP; O'Dwyer, PJ; Ozols, RF | 1 |
| Miranda, AF; Wells, PG; Wiley, MJ | 1 |
| Gopalan-Kriczky, P; Hiruma, S; Lotlikar, PD | 1 |
| Atzori, L; Dypbukt, JM; Grafström, RC; Hybbinette, SS; Moldéus, P | 1 |
| Buckpitt, A; Cho, M; Hammock, B; Jedrychowski, R | 1 |
| Sugiyama, M; Tsuzuki, K | 1 |
| Alptekin, N; Koçak-Toker, N; Mutlu-Türkoğlu, U; Uysal, M | 1 |
| Chase, CC; Guerriero, V; Gutierrez, JA; Hammond, AC; Hansen, PJ; Kamwanja, LA; Olson, TA | 1 |
| Cantoni, O; Cattabeni, F; Guidarelli, A; Sestili, P | 1 |
| Lee, JH; Naito, M; Tsuruo, T | 1 |
| Alena, F; Gili, A; Iwashina, T; Jimbow, K | 1 |
| Hayek, M; Meydani, M; Meydani, SN; Sastre, J; Wu, D | 1 |
| Kelce, WR | 1 |
| Fujiyama, J; Hirayama, K; Yasutake, A | 1 |
| Davidson, PC; Jones, DP; Reed, RL; Sternberg, P | 1 |
| Koch, CJ; Skov, KA | 1 |
| Ding, L; Jin, Y; Ni, C; Wang, W; Yi, X | 1 |
| Edgren, MR; Révész, L; Wainson, AA | 1 |
| Hempel, SL; Wessels, DA | 1 |
| Anton, R; Bredesen, DE; Gralla, EB; Hahn, H; Kane, DJ; Ord, T; Sarafian, TA; Valentine, JS | 1 |
| Curthoys, NP; Hughey, RP; Scott, RD | 1 |
| Harrap, KR; Kelland, LR; Loh, SY; Mistry, P | 1 |
| Darley-Usmar, VM; Gotoh, N; Graham, A; Nikl, E | 1 |
| Chigurupati, R; Frischer, H; Kennedy, EJ; Sivarajan, M | 1 |
| Davidson, PC; Drews-Botsch, C; Hagen, TM; Jones, DP; Reed, RL; Sternberg, P | 1 |
| Beyers, KL; Siemann, DW | 1 |
| Bergelson, S; Daniel, V; Pinkus, R | 1 |
| St Clair, DK; Wan, XS | 2 |
| Alberti, D; Arzoomanian, RZ; Bailey, HH; Mulcahy, RT; Pomplun, M; Spriggs, DR; Tombes, MB; Tutsch, KD; Wilding, G | 1 |
| Campisi, A; Castorina, C; Di Giacomo, C; Perez-Polo, JR; Renis, M; Russo, A; Sorrenti, V; Vanella, A | 1 |
| Huang, HS; Jurima-Romet, M | 1 |
| Begg, AC; Los, G; Oldenburg, J; Pinedo, HM; Ruevekamp, M; Schornagel, JH; van Vugt, MJ | 1 |
| Fanburg, BL; Hassoun, PM; Thannickal, VJ; White, AC | 1 |
| Calvin, HI; Fu, SC; Laver, NM; Robison, WG | 1 |
| Fry, JR; Hammond, AH | 1 |
| Mizutani, Y; Yoshida, O | 1 |
| Brown, D; Donaldson, K; Lannan, S; MacNee, W | 1 |
| Dockery, SP; Harrison, DG; Kurz, MA; Sayegh, HS; Wheatley, RM | 1 |
| Ceccarelli, D; Gallesi, D; Giovannini, F; Masini, A; Trenti, T | 1 |
| Gupta, V; Singh, SV; Xu, BH | 1 |
| Chai, YC; Hendrich, S; Lii, CK; Thomas, JA; Zhao, W | 1 |
| Brandt, I; Brittebo, EB; Darnerud, PO; Eriksson, C | 1 |
| Huang, CF; Huang, H; Jan, KY; Jinn, CM; Wu, DR | 1 |
| Clark, EP; Gafner, J; Miller, AC; Samid, D | 1 |
| Ichikawa, A; Koizumi, T; Negishi, M | 1 |
| Gopalan, P; Kimura, M; Lehmann, K; Lotlikar, PD; Sato, K; Shinozuka, H; Tsuji, K | 1 |
| Hou, RF; Jan, KY; Wang, TC; Wei, LY | 1 |
| Hänninen, O; Rahkila, P; Sen, CK | 1 |
| Dalhoff, K; Poulsen, HE | 1 |
| Furukawa, T; Ishibiki, K; Kitajima, M; Kubota, T; Kuo, TH; Saikawa, Y; Tanino, H; Watanabe, M | 1 |
| Davenport, LD; Lynch, RE; Mullenbach, GT; Speranza, MJ; Taylor, SD | 1 |
| Hamano, S; Kuwayama, M; Nagai, T; Okamura, N; Okano, A; Takahashi, M | 1 |
| Devesa, A; Garciá, C; O'Connor, JE; Puertes, IR; Viña, JR | 1 |
| Hirata, J; Imaizumi, E; Ishii, K; Kikuchi, Y; Kita, T; Kudoh, K; Nagata, I; Tode, T | 1 |
| Cohen, G; Han, SK; Mytilineou, C | 1 |
| Eisert, DR; Freeman, ML; Meredith, MJ; Sierra-Rivera, E; Voorhees, GJ | 1 |
| Cairns, J; Guy, GR; Ng, SB; Tan, YH | 1 |
| Hubbard, AK; Lombard-Gillooly, K | 1 |
| Zdolsek, JM | 1 |
| Kelce, WR; Zirkin, BR | 1 |
| Garcia, A; Gasull, T; Giralt, M; Hernandez, J; Hidalgo, J | 1 |
| Aldershvile, J; Anderson, ME; Boesgaard, S; Loft, S; Meister, A; Poulsen, HE | 1 |
| Ballinari, D; Broggini, M; D'Incalci, M; Erba, E; Geroni, C; Grandi, M; Mongelli, N; Pesenti, E; Spreafico, F; Tagliabue, G | 1 |
| Bloomer, WD; Damodaran, KM; Prezioso, JA; Wang, N | 1 |
| Chin, TA; Templeton, DM | 1 |
| Abraham, I; Adams, EG; Bhuyan, BK; Kelly, RC; Sampson, KE; Smith, KS | 1 |
| Ewing, JF; Maines, MD | 1 |
| Canada, A; Herman, L; Kidd, K; Robertson, C; Trump, D | 1 |
| Geiger, PG; Girotti, AW; Thomas, JP | 1 |
| Appenroth, D; Winnefeld, K | 1 |
| Arguello, F; Cohen, HJ; Eskenazi, AE; Frantz, CN; Pinkas, J; Whitin, JC | 1 |
| Cargill, I; Howell, S; Lindenthal, J; Sinclair, JF; Sinclair, PR; Taylor, T | 1 |
| Borsellino, N; Crescimanno, M; D'Alessandro, N; Flandina, C; Leonardi, V; Rausa, L | 1 |
| Beydon, D; de Ceaurriz, J; Grandclaude, MC; Langonné, I; Payan, JP; Sabaté, JP; Saillenfait, AM | 1 |
| Lee, KH; Vessey, DA | 1 |
| Jornot, L; Junod, AF | 1 |
| Asensi, M; Estrela, JM; Lasso de la Vega, MC; Puertes, IR; Terradez, P; Viña, J | 1 |
| Yoshida, M | 1 |
| Mulcahy, RT; Ripple, M; Wilding, G | 1 |
| Graff, RD; Lowndes, HE; Philbert, MA; Reuhl, KR | 1 |
| Harris, C; Hiranruengchok, R | 1 |
| Balasubramanian, KA; Benard, O | 1 |
| Arruda, JA; Dunea, G; Garber, SL | 1 |
| Elliott, SJ; Henschke, PN | 1 |
| Hussein, AS; Walter, RD | 2 |
| Furukawa, Y; Sugiyama, M; Susa, N; Ueno, S | 1 |
| Bolognia, JL; Osber, MP; Pawelek, JM; Sodi, SA | 1 |
| Donaldson, K; Golyasnya, N | 1 |
| Furusawa, S; Hikichi, N; Kisara, S; Murata, R; Ogata, M; Sasaki, K; Takayanagi, Y | 1 |
| Holland, JA; Meyer, JW; Ziegler, LM | 1 |
| Bookman, MA; Brennan, J; Comis, RL; Gallo, JM; Halbherr, T; Hamilton, TC; Hoffman, J; Kilpatrick, D; LaCreta, FP; O'Dwyer, PJ; Ozols, RF; Young, RC | 1 |
| Parekh, H; Simpkins, H | 1 |
| Holmgren, A; Spyrou, G | 1 |
| Ambesi-Impiombato, FS; Curcio, F; Donnini, D; Perrella, G; Zambito, AM | 1 |
| Asensi, M; Estrela, JM; Garcia-España, A; Pallardó, FV; Vina, J | 1 |
| Brusilow, SW; Hirata, T; Kawaguchi, T; Koehler, RC; Traystman, RJ | 2 |
| Eger, EI; Kandel, L; Kerschmann, RL; Laster, MJ; Martin, JL; Reed, GF | 1 |
| DeLeve, LD; Kaplowitz, N; Kuhlenkamp, JF; Wang, X | 1 |
| Benito, M; Carrizosa, R; Fabregat, I; Martínez-Honduvilla, C; Mesa, ML | 1 |
| Maitra, I; Packer, L; Serbinova, E; Tritschler, HJ | 1 |
| Kang, YJ; Uthus, EO | 1 |
| Egner, PA; Kensler, TW; King, JK | 1 |
| Canonico, PL; Sortino, MA | 1 |
| Faux, SP; Howden, PJ | 1 |
| Ben-Yoseph, O; Boxer, PA; Ross, BD | 1 |
| Adamson, B; Fisher, J; Gilmont, R; Klugston, P; Lindblad, W; Perry, L; Rees, R; Schwarz, D | 1 |
| Hirakawa, T; Honda, S; Kishi, K; Rokutan, K; Teshima, S | 1 |
| Cortazzo, M; Schor, NF | 1 |
| Allouche, M; Bailly, JD; Bordier, C; Come, MG; Duchayne, E; Laurent, G; Mansat, V; Quillet-Mary, A | 1 |
| Chiba, T; Ishii, S; Kikuchi, K; Sato, N; Takahashi, S | 1 |
| Devasagayam, TP; Kesavan, PC; Mittal, JP; Mohan, H; Sarma, L | 1 |
| Ali-Osman, F; Antoun, G; Gagucas, E; Rajagopal, S; Wang, H | 1 |
| Allen, RG; Cristofalo, VJ; Horton, J; Keogh, BP; Pignolo, R; Tresini, M | 1 |
| Carlson, GP; DeNicola, DB; Gadberry, MG | 1 |
| Barreto, JC; Miller, TA; Smith, GS; Tornwall, MS | 1 |
| Dettbarn, WD; Yang, ZP | 1 |
| Hirata, I; Kishimoto, H; Koyama, H; Ohta, T; Sugioka, N | 1 |
| Blaheta, RA; Cinatl, J; Doerr, HW; Freisleben, HJ; Gross, V; Markus, BH; Scholz, M; Vogel, JU | 1 |
| Bánhegyi, G; Braun, L; Csala, M; Garzó, T; Mandl, J; Poussu, A | 1 |
| Lash, LH; Pegouske, DM; Putt, DA; Schare, JM; Visarius, TM | 1 |
| Baker, ER; Baker, H; DeAngelis, B; Frank, O; Hutner, SH; Khalil, M | 1 |
| Fiebig, R; Gore, M; Hollander, J; Ji, LL; Leeuwenburgh, C; Leichtweis, S | 1 |
| Bastiaanse, EM; Egas, JM; Van der Laarse, A; Van Dockum, WG; Verbunt, RJ | 1 |
| Agostinelli, E; Averill-Bates, DA; Przybytkowski, E | 1 |
| Bolaños, JP; Brand, MP; Clark, JB; Heales, SJ; Land, JM | 1 |
| Behrens, MM; Chen, MM; Choi, DW; Dugan, LL; Gwag, BJ; Koh, JY; Lobner, D | 1 |
| Dackiw, AP; Marshall, JC; Nathens, AB; Rotstein, OD; Watson, RW | 1 |
| Benson, PJ; Gupta, V; Hu, X; Pinto, T; Singh, S; Xia, H; Zaren, HA | 1 |
| Lévi, F; Li, XM; Metzger, G; Mormont, C | 1 |
| Barger, SW; Hennig, B; Mattson, MP; McClain, CJ; Toborek, M | 1 |
| Andreotti, PE; Bruckner, HW; Krebs, D; Kurbacher, CM; Kurbacher, JA; Sass, G | 1 |
| Bagrij, T; Twentyman, PR; Versantvoort, CH; Wright, KA | 1 |
| Brusilow, SW; Cork, LC; Hirata, T; Koehler, RC; Takahashi, H; Traystman, RJ; Willard-Mack, CL | 1 |
| Bains, JS; Shaw, CA | 1 |
| Shirasawa, N; Yamanouchi, H | 1 |
| Barnett, NL; Pow, DV; Robinson, SR | 1 |
| Iwabuchi, M; Mino, M; Ogawa, K; Tanaka, Y; Tasaka, Y | 1 |
| McGrath-Morrow, SA; Stahl, J | 1 |
| de Licastro, SA; Reinhard, MB | 1 |
| Feary, M; Racher, AJ; Smales, CM; Young, RJ | 1 |
| Anraku, Y; Ikoma, T; Nakagawa, Y; Quindoza, GM | 1 |
| Barros Ibiapina, A; Carneiro da Silva, FC; de Castro E Sousa, JM; Dos Reis Oliveira, C; Ferreira, PMP; Pereira, JC; Roseno Martins, IR | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
18 review(s) available for buthionine sulfoximine and methionine sulfoximine
| Article | Year |
|---|---|
Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants.
Topics: Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Buthionine Sulfoximine; Disease Models, Animal; Glutathione; Methionine Sulfoximine; Rats | 1992 |
Modulation of antitumour drug resistance: experimental laboratory data and results of clinical evaluation.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Dipyridamole; Drug Resistance; Glutathione; Humans; Leucovorin; Membrane Glycoproteins; Methionine Sulfoximine; Verapamil | 1990 |
The role of glutathione in drug resistance.
Topics: Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; DNA Repair; Drug Resistance; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms | 1990 |
Guarding against cellular glutathione deficiency.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Glutathione; Humans; Methionine Sulfoximine; Radiation-Protective Agents | 1990 |
Metabolism and action of amino acid analog anti-cancer agents.
Topics: Amino Acids; Animals; Antineoplastic Agents; Aspartic Acid; Buthionine Sulfoximine; Eflornithine; Glutamine; Humans; Methionine Sulfoximine | 1990 |
Glutathione modulation in cancer treatment: will it work?
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Glutathione; Humans; Methionine Sulfoximine; Neoplasms; Radiation-Sensitizing Agents | 1989 |
Non-chemotherapeutic agents that potentiate chemotherapy efficacy.
Topics: Adult; Amphotericin B; Animals; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Calcium Channel Blockers; Calmodulin; Cardiotonic Agents; Child; Clinical Trials as Topic; Dipyridamole; Drug Evaluation; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Methionine Sulfoximine; Mice; Neoplasms; Nitroimidazoles; Xanthines | 1989 |
Biochemistry of reduction of nitro heterocycles.
Topics: Animals; Buthionine Sulfoximine; Catalase; Cell Division; Cell Survival; Etanidazole; Free Radicals; Glucose; Glutathione; Glycolysis; Hexosephosphates; Humans; Hypoxia; Methionine Sulfoximine; Microbodies; Microsomes; Misonidazole; Mitochondria; Nitroimidazoles; Oxidation-Reduction; Pentoses; Peroxidases; Sulfhydryl Compounds | 1986 |
Glutathione and cadmium toxicity.
Topics: Animals; Buthionine Sulfoximine; Cadmium; Cadmium Poisoning; Glutathione; Humans; Metallothionein; Methionine Sulfoximine; Mice | 1988 |
The roles of intracellular glutathione in antineoplastic chemotherapy.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Survival; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1986 |
The use of non-hypoxic cell sensitizers in radiobiology and radiotherapy.
Topics: Animals; Bromodeoxyuridine; Buthionine Sulfoximine; Cell Survival; Cricetinae; Diamide; DNA Repair; Glutathione; Humans; Idoxuridine; In Vitro Techniques; Methionine Sulfoximine; Neoplasms; Radiation-Sensitizing Agents | 1986 |
New aspects of glutathione biochemistry and transport--selective alteration of glutathione metabolism.
Topics: Animals; Biological Transport; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Glutathione Synthase; Humans; Metabolism, Inborn Errors; Methionine Sulfoximine; Mice; Neoplasms, Experimental; Pyroglutamate Hydrolase; Radiation-Sensitizing Agents; Rats; Thiazoles | 1984 |
In vivo and in vitro mechanisms of radiation sensitization, drug synthesis and screening: can we learn it all from the high dose data?
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Cricetinae; Diamide; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1984 |
Mitochondrial changes associated with glutathione deficiency.
Topics: Animals; Animals, Newborn; Antimetabolites; Ascorbic Acid; Buthionine Sulfoximine; Cerebral Cortex; Glutathione; Guinea Pigs; Liver; Methionine Sulfoximine; Mice; Mitochondria; Mitochondria, Liver; Models, Biological; Rats | 1995 |
Modulation of glutathione and related enzymes in reversal of resistance to anticancer drugs.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; CHO Cells; Cricetinae; Drug Resistance; Ethacrynic Acid; Female; gamma-Glutamyltransferase; Gene Expression Regulation, Neoplastic; Glutathione; Glutathione Peroxidase; Glutathione Synthase; Glutathione Transferase; Humans; Inactivation, Metabolic; Male; Methionine Sulfoximine; Neoplasm Proteins; Oxidation-Reduction; Thiotepa; Tumor Cells, Cultured | 1995 |
Glutathione metabolism.
Topics: Animals; Buthionine Sulfoximine; Cysteine; Enzymes; Glutathione; Methionine Sulfoximine; Models, Biological; Oxidation-Reduction | 1995 |
Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts.
Topics: Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cataract; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Humans; Lens, Crystalline; Methionine Sulfoximine; Rats; Rats, Wistar; Thioctic Acid | 1994 |
Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta-analysis of preclinical studies.
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Drug Resistance, Neoplasm; Humans; Methionine Sulfoximine; Neoplasms | 2023 |
5 trial(s) available for buthionine sulfoximine and methionine sulfoximine
| Article | Year |
|---|---|
Non-chemotherapeutic agents that potentiate chemotherapy efficacy.
Topics: Adult; Amphotericin B; Animals; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Calcium Channel Blockers; Calmodulin; Cardiotonic Agents; Child; Clinical Trials as Topic; Dipyridamole; Drug Evaluation; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Methionine Sulfoximine; Mice; Neoplasms; Nitroimidazoles; Xanthines | 1989 |
Time-dependent pharmacodynamic models in cancer chemotherapy: population pharmacodynamic model for glutathione depletion following modulation by buthionine sulfoximine (BSO) in a Phase I trial of melphalan and BSO.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Enzyme Inhibitors; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Neoplasms; Neutrophils | 1995 |
Variable baseline gamma-glutamylcysteine synthetase messenger RNA expression in peripheral mononuclear cells of cancer patients, and its induction by buthionine sulfoximine treatment.
Topics: Adult; Antimetabolites, Antineoplastic; Base Sequence; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutamate-Cysteine Ligase; Humans; Male; Methionine Sulfoximine; Molecular Sequence Data; Neoplasms; Polymerase Chain Reaction; RNA, Messenger | 1993 |
Phase I clinical trial of intravenous L-buthionine sulfoximine and melphalan: an attempt at modulation of glutathione.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Female; Glutathione; Humans; Infusions, Intravenous; Male; Melphalan; Methionine Sulfoximine; Middle Aged; Neoplasms | 1994 |
Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Linear Models; Male; Melphalan; Methionine Sulfoximine; Middle Aged; Nausea; Neoplasm Recurrence, Local; Neoplasms; Neutropenia; Neutrophils; Radiography; Vomiting | 1996 |
846 other study(ies) available for buthionine sulfoximine and methionine sulfoximine
| Article | Year |
|---|---|
Selenite-induced inhibition of colony formation by buthionine sulfoximine-sensitive and resistant cell lines.
Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Line; Clone Cells; Colony-Forming Units Assay; Humans; Methionine Sulfoximine; Selenium; Sodium Selenite; Tumor Cells, Cultured | 1992 |
Depletion of glutathione in normal and malignant human cells in vivo by L-buthionine sulfoximine: possible interaction with ascorbate.
Topics: Animals; Antimetabolites, Antineoplastic; Ascorbic Acid; Buthionine Sulfoximine; Glutathione; Humans; Methionine Sulfoximine | 1992 |
Effects of buthionine sulfoximine treatment on cellular glutathione levels and cytotoxicities of cisplatin, carboplatin and radiation in human stomach and ovarian cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Buthionine Sulfoximine; Carboplatin; Cisplatin; Female; Glutathione; Humans; Methionine Sulfoximine; Ovarian Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy; Stomach Neoplasms; Tumor Cells, Cultured | 1992 |
Interaction of buthionine sulfoximine and the stabilization of DNA-topoisomerase II complexes by doxorubicin.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; DNA Topoisomerases, Type II; Doxorubicin; Enzyme Stability; Free Radicals; Glutathione; Methionine Sulfoximine | 1992 |
A procedure for selecting mammalian cells with an impairment in oxidative phosphorylation.
Topics: Animals; Buthionine Sulfoximine; Cell Separation; Cell Survival; CHO Cells; Cricetinae; Cytochrome-c Oxidase Deficiency; Electron Transport Complex IV; Electrophoresis; Humans; Immunoblotting; Methionine Sulfoximine; Mitochondria; Mutation; Oxidative Phosphorylation; Phenotype; Pyridinium Compounds; Ultraviolet Rays | 1992 |
Roles of glutathione and glutathione peroxidase in the protection against endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid.
Topics: Animals; Antioxidants; Azoles; Buthionine Sulfoximine; Carotid Arteries; Cattle; Cells, Cultured; Endothelium, Vascular; Glutathione; Glutathione Peroxidase; Isoindoles; Kinetics; Leukotrienes; Lipid Peroxides; Maleates; Methionine Sulfoximine; Organoselenium Compounds; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Selenium; Sodium Selenite; Thiazoles; Thiazolidines | 1992 |
Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma, Non-Small-Cell Lung; Cisplatin; Doxorubicin; Drug Synergism; Etoposide; Female; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil | 1992 |
In vivo formation of chromium(V) in chick embryo liver and red blood cells.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Chick Embryo; Chromates; Chromium; Electron Spin Resonance Spectroscopy; Erythrocytes; Glutathione; Kinetics; Liver; Methionine Sulfoximine | 1992 |
Relationship between melanogenesis, glutathione levels and melphalan toxicity in human melanoma cells.
Topics: Bucladesine; Buthionine Sulfoximine; Cell Differentiation; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Eye Neoplasms; Glutathione; Glutathione Transferase; Humans; Kinetics; Melanins; Melanoma; Melphalan; Methionine Sulfoximine; Microscopy, Electron; Monophenol Monooxygenase; Neoplasm Staging; Skin Neoplasms; Tumor Cells, Cultured | 1992 |
A scientific basis for proposed quality assurance of a new screening method for tumor-like growths in the planarian, Dugesia dorotocephala.
Topics: Animals; Antimetabolites; Aroclors; Buthionine Sulfoximine; Cadmium; Cadmium Compounds; Carcinogens; Chlorodiphenyl (54% Chlorine); Head; Incidence; Locomotion; Methionine Sulfoximine; Motor Activity; Neoplasms, Experimental; Planarians; Polychlorinated Biphenyls; Quality Control; Regeneration; Research; Sulfates | 1992 |
Overexpression of glutathione S-transferase and elevation of thiol pools in a multidrug-resistant human colon cancer cell line.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Colonic Neoplasms; Doxorubicin; Drug Resistance; Gene Expression; Glutathione; Glutathione Transferase; HeLa Cells; Humans; Membrane Glycoproteins; Membrane Proteins; Methionine Sulfoximine; Neoplasm Proteins; Phenotype; Sulfhydryl Compounds; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Effect of BSO on the radiation response at low (0-4 Gy) doses.
Topics: Animals; Buthionine Sulfoximine; Cell Hypoxia; CHO Cells; Cricetinae; Glutamate-Cysteine Ligase; Methionine Sulfoximine; Radiation-Sensitizing Agents | 1992 |
Regulation of total ovarian glutathione content in the rat.
Topics: Animals; Buthionine Sulfoximine; Female; Glutamate-Cysteine Ligase; Glutathione; Gonadotropins, Equine; Methionine Sulfoximine; Ovary; Rats; Rats, Inbred Strains | 1992 |
Effects of buthionine sulfoximine and diethyl maleate on glutathione turnover in the channel catfish.
Topics: Animals; Buthionine Sulfoximine; Cytosol; Depression, Chemical; Gills; Glutamate-Cysteine Ligase; Glutathione; Ictaluridae; Liver; Maleates; Methionine Sulfoximine; Mitochondria; Peptidyl Transferases; Starvation; Time Factors | 1992 |
Cytoprotective effect of reduced glutathione in hydrogen peroxide-induced endothelial cell injury.
Topics: Animals; Buthionine Sulfoximine; Catalase; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Glutamate-Cysteine Ligase; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine | 1992 |
Cyclophosphamide resistance in medulloblastoma.
Topics: Aldehyde Dehydrogenase; Buthionine Sulfoximine; Cerebellar Neoplasms; Child; Child, Preschool; Cyclophosphamide; Drug Resistance; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Humans; Infant; Male; Medulloblastoma; Methionine Sulfoximine; Sensitivity and Specificity; Tumor Cells, Cultured | 1992 |
Myocardial glutathione depletion impairs recovery of isolated blood-perfused hearts after global ischaemia.
Topics: Animals; Buthionine Sulfoximine; Cats; Creatine Kinase; Female; Glutamate-Cysteine Ligase; Glutathione; In Vitro Techniques; Male; Methionine Sulfoximine; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion | 1992 |
Increases in urinary enzyme excretion in rats depleted of glutathione inhibited by scavenger of oxygen free radicals.
Topics: Acetylglucosaminidase; Animals; Blood Urea Nitrogen; Buthionine Sulfoximine; Cisplatin; Enzymes; Free Radical Scavengers; gamma-Glutamyltransferase; Glutathione; Kidney Cortex; Male; Maleates; Methionine Sulfoximine; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Thiourea | 1992 |
The effect of estrous cycle and buthionine sulfoximine on glutathione release from the in vitro perfused rat ovary.
Topics: Animals; Buthionine Sulfoximine; Estrus; Female; Glutamate-Cysteine Ligase; Glutathione; In Vitro Techniques; Lactates; Lactic Acid; Methionine Sulfoximine; Ovary; Perfusion; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1992 |
The relative importance of glutathione and metallothionein on protection of hepatotoxicity of menadione in rats.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Chemical and Drug Induced Liver Injury; Cytosol; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Metallothionein; Methionine Sulfoximine; Phenobarbital; Potassium; Rats; Rats, Sprague-Dawley; Sulfates; Vitamin K; Zinc; Zinc Sulfate | 1992 |
Caffeic acid causes metal-dependent damage to cellular and isolated DNA through H2O2 formation.
Topics: Amitrole; Autoradiography; Buthionine Sulfoximine; Caffeic Acids; Catalase; Cells, Cultured; DNA Damage; Electrophoresis, Agar Gel; Electrophoresis, Gel, Pulsed-Field; Free Radical Scavengers; Humans; Hydrogen Peroxide; Metals; Methionine Sulfoximine; Phenanthrolines; Proto-Oncogenes; Spectrophotometry, Ultraviolet | 1992 |
Endogenous glutathione levels modulate the frequency of both spontaneous and long wavelength ultraviolet induced mutations in human cells.
Topics: Buthionine Sulfoximine; Cells, Cultured; Glutathione; Humans; Hypoxanthine Phosphoribosyltransferase; Methionine Sulfoximine; Mutation; Radiation-Sensitizing Agents; Ultraviolet Rays | 1992 |
Glutathione depletion enhances subanesthetic halothane hepatotoxicity in guinea pigs.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Guinea Pigs; Halothane; Liver; Male; Methionine Sulfoximine | 1992 |
Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione.
Topics: Animals; Aziridines; Buthionine Sulfoximine; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutathione; Methionine Sulfoximine; Misonidazole; Mutagenicity Tests; Mutation; Oxidation-Reduction; Oxygen; Thioguanine | 1992 |
Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine. Correlation with enhanced alkylating agent cytotoxicity to human melanoma cells in vitro.
Topics: Buthionine Sulfoximine; Carmustine; Cell Division; Cell Nucleus; Cytosol; Doxorubicin; Drug Synergism; Glutathione; Glutathione Disulfide; Humans; Melanoma; Melphalan; Methionine Sulfoximine; Oxidation-Reduction; Tumor Cells, Cultured | 1992 |
Membrane lipid modification and sensitivity of leukemic cells to the thioether lipid analogue BM 41.440.
Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Biological Transport; Buthionine Sulfoximine; Cell Membrane; Culture Media; Drug Screening Assays, Antitumor; Fatty Acids; Glutathione; Iron; Leukemia L1210; Membrane Lipids; Methionine Sulfoximine; Mice; Phospholipid Ethers; Tritium; Tumor Cells, Cultured | 1992 |
Effect of buthionine sulfoximine and ethacrynic acid on cytotoxic activity of mitomycin C analogues BMY 25282 and BMY 25067.
Topics: Animals; Buthionine Sulfoximine; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Ethacrynic Acid; Glutathione Transferase; Leukemia P388; Methionine Sulfoximine; Mitomycin; Mitomycins; Tumor Stem Cell Assay | 1992 |
The effects of cyclosporin A on the lysis of ovarian cancer cells by cisplatin or adriamycin.
Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Death; Cisplatin; Cycloheximide; Cyclosporine; Doxorubicin; Drug Interactions; Drug Resistance; Emetine; Female; Humans; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil | 1992 |
Effects of 2-mercaptoethanol and buthionine sulfoximine on cystine metabolism by and proliferation of mitogen-stimulated human and mouse lymphocytes.
Topics: Adolescent; Adult; Animals; Antimetabolites; Buthionine Sulfoximine; Cystine; Glutathione; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Mercaptoethanol; Methionine Sulfoximine; Mice; Mice, Inbred CBA; Protein Biosynthesis; Species Specificity; T-Lymphocytes | 1992 |
Glutathione deficiency increases hepatic ascorbic acid synthesis in adult mice.
Topics: Animals; Ascorbic Acid; Buthionine Sulfoximine; Glutathione; Kidney; Liver; Lung; Male; Methionine Sulfoximine; Mice | 1992 |
Oxygen-induced lung damage. Relationship to lung mitochondrial glutathione levels.
Topics: Animals; Buthionine Sulfoximine; Glutathione; Lung; Lung Diseases; Male; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mitochondria; Oxygen | 1992 |
Relationship of cellular glutathione to the cytotoxicity and resistance of seven platinum compounds.
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Carboplatin; Cisplatin; Cyclobutanes; Drug Resistance; Glutathione; Humans; Methionine Sulfoximine; Organoplatinum Compounds; Tumor Cells, Cultured | 1992 |
The mechanism of Hg2+ toxicity in cultured human oral fibroblasts: the involvement of cellular thiols.
Topics: Buthionine Sulfoximine; Cell Division; Cell Survival; Cells, Cultured; Coloring Agents; Cysteine; Dental Amalgam; Deoxyglucose; Fibroblasts; Glutathione; Humans; Mercury; Methionine Sulfoximine; Mouth; Neutral Red; Sulfhydryl Compounds; Tetrazolium Salts; Thiazoles | 1992 |
Effects of glutathione depletion using buthionine sulphoximine on the cytotoxicity in mammalian cells and human tumor cells in vitro.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Hypoxia; Cisplatin; Drug Synergism; Fluorouracil; Glutathione; Humans; Leukemia, Erythroblastic, Acute; Methionine Sulfoximine; Misonidazole; Stomach Neoplasms; Tumor Cells, Cultured | 1992 |
Production of lipid hydroperoxides and depletion of reduced glutathione in liver mitochondria after acute ethanol administration to rats.
Topics: Animals; Buthionine Sulfoximine; Ethanol; Female; Glutathione; Lipid Peroxides; Methionine Sulfoximine; Mitochondria, Liver; Rats; Rats, Sprague-Dawley | 1992 |
[Alterations in phosphatidylcholine and phospholipase A2 of the renal tissue in gentamicin nephrotoxicity: comparative study with buthionine sulfoximine administered model].
Topics: Acute Kidney Injury; Animals; Buthionine Sulfoximine; Disease Models, Animal; Gentamicins; Glutathione; Kidney; Lipid Peroxidation; Male; Methionine Sulfoximine; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley | 1992 |
[Plasma-membrane fluidity studies of murine neuroblastoma and malignant melanoma cells under irradiation].
Topics: Animals; Buthionine Sulfoximine; Cell Cycle; Cell Survival; Dose-Response Relationship, Radiation; Glutathione; Melanoma, Experimental; Membrane Fluidity; Methionine Sulfoximine; Mice; Neuroblastoma; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Tamoxifen; Tumor Cells, Cultured | 1992 |
Modulation by glutathione of DNA strand breaks induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its aldehyde metabolites in rat hepatocytes.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Carcinogens; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme System; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Formaldehyde; Glutathione; Liver; Male; Methionine Sulfoximine; Nitrosamines; Pyridines; Rats; Rats, Inbred F344 | 1992 |
Influence of modulators of epoxide metabolism on the cytotoxicity of trans-anethole in freshly isolated rat hepatocytes.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Antimetabolites; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Chalcone; Chalcones; Cyclohexanes; Cyclohexenes; Dose-Response Relationship, Drug; Epoxide Hydrolases; Epoxy Compounds; Female; Flavoring Agents; Glutathione; L-Lactate Dehydrogenase; Liver; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Trichloroepoxypropane | 1992 |
Role of glutathione in repair of free radical damage in hippocampus in vitro.
Topics: Animals; Buthionine Sulfoximine; Diamide; Dimethyl Fumarate; Electric Stimulation; Evoked Potentials; Free Radicals; Fumarates; Glutathione; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Methionine Sulfoximine; Pyramidal Tracts; Radiation-Sensitizing Agents; Synapses | 1992 |
Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Survival; Chlorambucil; DNA; Drug Interactions; Drug Resistance; Glutathione; Glutathione Transferase; Mammary Neoplasms, Experimental; Mechlorethamine; Melphalan; Methionine Sulfoximine; Rats; RNA, Messenger; Tumor Cells, Cultured | 1992 |
Divergent effects of intravenous GSH and cysteine on renal and hepatic GSH.
Topics: Animals; Buthionine Sulfoximine; Cysteine; Dose-Response Relationship, Drug; Glutathione; Injections, Intravenous; Kidney; Kinetics; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1992 |
Effect of treatment duration and glutathione depletion on mitomycin C cytotoxicity in vitro.
Topics: Buthionine Sulfoximine; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Mitomycin; Tumor Cells, Cultured | 1992 |
Potentiation by thiopurines and sulfhydryl-reactive agents of the inhibition by 3-deazaadenosine of mononuclear phagocytes.
Topics: Animals; Azathioprine; Buthionine Sulfoximine; Cells, Cultured; Cyclohexanones; Drug Synergism; Ethacrynic Acid; Glutathione; Mercaptopurine; Methionine Sulfoximine; Mice; Phagocytes; Phagocytosis; Tubercidin | 1992 |
The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Dose-Response Relationship, Radiation; Glioma; Glutathione; Humans; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Radiation-Sensitizing Agents; Survival Rate; Transplantation, Heterologous | 1992 |
Melanoma cytotoxicity of buthionine sulfoximine (BSO) alone and in combination with 3,4-dihydroxybenzylamine and melphalan.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Dopamine; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Melanoma; Melanoma, Experimental; Melphalan; Methionine Sulfoximine; Mice; Tumor Cells, Cultured | 1992 |
Changes in conjugative enzyme activity and acetaminophen metabolism in young and senescent male F-344 rats following prolonged exposure to buthionine sulfoximine.
Topics: Acetaminophen; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Glutathione; Glutathione Transferase; Liver; Male; Methionine Sulfoximine; Oxidoreductases, O-Demethylating; Rats; Rats, Inbred F344; Sulfotransferases | 1992 |
Increase in rat brain glutathione following intracerebroventricular administration of gamma-glutamylcysteine.
Topics: Animals; Brain; Brain Stem; Buthionine Sulfoximine; Corpus Striatum; Cysteine; Dipeptides; Glutathione; Injections, Intraventricular; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Substantia Nigra | 1992 |
Dichotomy of glutathione regulation of the activation of resting and preactivated lymphocytes.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Buthionine Sulfoximine; CD3 Complex; Female; Genes, myc; Glutathione; Interleukin-2; Killer Cells, Lymphokine-Activated; Lymphocyte Activation; Mercaptoethanol; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Receptors, Antigen, T-Cell; T-Lymphocyte Subsets; Time Factors; Transcription, Genetic | 1992 |
Depletion of brain glutathione by buthionine sulfoximine enhances cerebral ischemic injury in rats.
Topics: Animals; Ascorbic Acid; Brain; Brain Ischemia; Buthionine Sulfoximine; Cerebral Infarction; Glutathione; Injections, Intraventricular; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1992 |
Role of lipid peroxidation and DNA damage in paraquat toxicity and the interaction of paraquat with ionizing radiation.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Membrane; Cell Survival; DNA Damage; Dose-Response Relationship, Drug; Fatty Acids; Lipid Peroxidation; Liver; Male; Maleates; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Paraquat; Radiation Dosage; Radiation-Sensitizing Agents; Temperature; Tumor Cells, Cultured; Vitamin E | 1992 |
Hepsulfam sensitivity in human breast cancer cell lines: the role of glutathione and glutathione S-transferase in resistance.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Buthionine Sulfoximine; Glutathione; Glutathione Transferase; Humans; Isoenzymes; Methionine Sulfoximine; Sulfonic Acids; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1992 |
The effect of changes in thiol subcompartments on T-cell colony formation and cell cycle progression: relevance to AIDS.
Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Buthionine Sulfoximine; Cell Compartmentation; Cell Cycle; Cells, Cultured; Colony-Forming Units Assay; Cyclohexanones; Humans; Mercaptoethanol; Methionine Sulfoximine; Protein Kinase C; Sulfhydryl Compounds; T-Lymphocytes | 1992 |
Heterogeneity in response to treatment with buthionine sulfoximine or interferon in human malignant glioma cells.
Topics: Buthionine Sulfoximine; Carmustine; Humans; In Vitro Techniques; Interferon-alpha; Mechlorethamine; Methionine Sulfoximine; Recombinant Proteins; Tumor Cells, Cultured | 1992 |
BSO-induced reduction of glutathione levels increases the cellular radiosensitivity of drug-resistant human tumor cells.
Topics: Buthionine Sulfoximine; Depression, Chemical; Drug Resistance; Female; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Radiation Tolerance; Tumor Cells, Cultured | 1992 |
Thiol manipulation as a means of overcoming drug resistance in a novel cyclophosphamide-induced resistant cell line.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Resistance; Glutathione; In Vitro Techniques; Methionine Sulfoximine; Mice; Tumor Cells, Cultured | 1992 |
Sensitization of drug resistant human ovarian cancer cells to cyanomorpholino doxorubicin (MRA-CN) by modulation of glutathione metabolism.
Topics: Antibiotics, Antineoplastic; Buthionine Sulfoximine; Cell Survival; Doxorubicin; Drug Resistance; Ethacrynic Acid; Female; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured | 1992 |
[1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. III. Detailed evaluation of the antitumor activity of the enantiomeric complexes on the human NIH:OVCAR-3 ovarian cancer cell line.
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cisplatin; Female; Glutathione; Humans; Methionine Sulfoximine; Organoplatinum Compounds; Ovarian Neoplasms; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 1992 |
Reduction of glutathione is associated with growth restriction and enlargement of bovine pulmonary artery endothelial cells produced by transforming growth factor-beta 1.
Topics: Animals; Buthionine Sulfoximine; Cattle; Cell Division; Cells, Cultured; Cystine; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Kinetics; Methionine Sulfoximine; Pulmonary Artery; Transforming Growth Factor beta | 1992 |
Effect of glutathione depletion on tissue and plasma prostacyclin and thromboxane in rats.
Topics: Animals; Buthionine Sulfoximine; Epoprostenol; Glutathione; Kidney; Liver; Lung; Male; Maleates; Methionine Sulfoximine; Methylcholanthrene; Rats; Rats, Inbred Strains; Thromboxane B2 | 1992 |
Effects of tyrosinase activity on the cytotoxicity of 4-S-cysteaminylphenol and N-acetyl-4-S-cysteaminylphenol in melanoma cells.
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cysteamine; Drug Synergism; Humans; Melanoma; Methionine Sulfoximine; Monophenol Monooxygenase; Phenols; Theophylline; Time Factors; Tumor Cells, Cultured | 1992 |
Glutathione production in copper-deficient isolated rat hepatocytes.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Copper; Free Radicals; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; In Vitro Techniques; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Superoxide Dismutase | 1992 |
Inhibition of elevated hepatic glutathione abolishes copper deficiency cholesterolemia.
Topics: Animals; Buthionine Sulfoximine; Cholesterol; Copper; Glutathione; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Liver; Male; Methionine Sulfoximine; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1992 |
Role of glutathione and glutathione S-transferase in chlorambucil resistance.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Southern; Buthionine Sulfoximine; Cell Survival; Chlorambucil; DNA; Drug Interactions; Drug Resistance; Ethacrynic Acid; Gene Rearrangement; Glutathione; Glutathione Transferase; Isoenzymes; Methionine Sulfoximine; Mice; RNA, Messenger | 1992 |
Demonstration of nuclear compartmentalization of glutathione in hepatocytes.
Topics: Animals; Bridged Bicyclo Compounds; Buthionine Sulfoximine; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Nucleus; Cells, Cultured; Cytosol; Ethylmaleimide; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Glutathione; Kinetics; Liver; Male; Maleates; Methionine Sulfoximine; Pyrazoles; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Subcellular Fractions; Vitamin K | 1992 |
Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium.
Topics: Animals; Buthionine Sulfoximine; Cadmium; Drug Interactions; Enzyme Induction; Glutathione; In Vitro Techniques; Liver; Male; Metallothionein; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Sulfates; Zinc; Zinc Sulfate | 1992 |
Ascorbic acid prevents oxidative stress in glutathione-deficient mice: effects on lung type 2 cell lamellar bodies, lung surfactant, and skeletal muscle.
Topics: Animals; Ascorbic Acid; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; Female; Glutathione; Lung Diseases; Methionine Sulfoximine; Mice; Microscopy, Electron; Mitochondria; Muscles; Oxidation-Reduction; Phosphatidylcholines; Pulmonary Surfactants | 1992 |
Accumulation of S-D-lactoylglutathione and transient decrease of glutathione level caused by methylglyoxal load in isolated hepatocytes.
Topics: Acetone; Animals; Buthionine Sulfoximine; Cells, Cultured; Dose-Response Relationship, Drug; Emetine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Pyruvaldehyde; Time Factors | 1992 |
Sex difference in the nephrotoxicity of thiabendazole in mice depleted of glutathione by treatment with DL-buthionine sulphoximine.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Estradiol; Female; Glutathione; Injections, Subcutaneous; Kidney; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Organ Size; Sex Factors; Testosterone; Thiabendazole | 1992 |
Progressive modifications of mouse lens crystallins in cataracts induced by buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Calcium; Cataract; Crystallins; Electrophoresis, Polyacrylamide Gel; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Molecular Weight; Time Factors | 1992 |
Lens GSH depletion and electrolyte changes preceding cataracts induced by buthionine sulfoximine in suckling mice.
Topics: Animals; Buthionine Sulfoximine; Calcium; Cataract; Female; Glutathione; Lens, Crystalline; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Potassium; Sodium; Time Factors | 1992 |
Nephrotoxicity of thiazoles structurally related to thiabendazole in mice depleted of glutathione by treatment with buthionine sulfoximine.
Topics: Animals; Benzimidazoles; Buthionine Sulfoximine; Glutathione; Kidney; Methionine Sulfoximine; Methoxsalen; Mice; Mice, Inbred ICR; Organ Size; Piperonyl Butoxide; Thiabendazole; Thiazoles | 1992 |
Protective effects of glutathione, glycine, or alanine in an in vitro model of renal anoxia.
Topics: Alanine; Animals; Buthionine Sulfoximine; Cells, Cultured; Glutathione; Glycine; Hypoxia; Ischemia; Kidney; L-Lactate Dehydrogenase; Methionine Sulfoximine; Probenecid; Rats | 1992 |
Characterization of a novel arachidonic acid-derived neutrophil chemoattractant.
Topics: Animals; Arachidonic Acids; Buthionine Sulfoximine; Cells, Cultured; Chemotactic Factors; Chromatography, High Pressure Liquid; Eicosanoic Acids; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Liver; Luminescent Measurements; Methionine Sulfoximine; Neutrophils; Rats | 1992 |
Mitochondrial inner membrane permeability changes induced by octadecadienoic acid hydroperoxide. Role of mitochondrial GSH pool.
Topics: Animals; Buthionine Sulfoximine; Female; Glutathione; Intracellular Membranes; Linoleic Acids; Lipid Peroxides; Methionine Sulfoximine; Mitochondria, Liver; Permeability; Rats; Rats, Inbred Strains | 1992 |
Relationship between glutathione content in liver and glutathione conjugation rate in the rat in vivo. Effect of buthionine sulphoximine pretreatment on conjugation of the two 2-bromoisovalerylurea enantiomers during intravenous infusion.
Topics: Acetylcysteine; Animals; Bromisovalum; Buthionine Sulfoximine; Glutathione; Infusions, Intravenous; Kinetics; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Stereoisomerism | 1992 |
Doxorubicin-induced cross-resistance to tumor necrosis factor (TNF) related to differential TNF processing.
Topics: Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Glutathione; Humans; Methionine Sulfoximine; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1991 |
Non-myelotoxic antitumour effects of L-dopa, buthionine sulphoximine and tamoxifen on neuroblastoma cells in vitro and in vivo.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Survival; Cyclic AMP; Glutathione; Humans; Levodopa; Male; Methionine Sulfoximine; Mice; Mice, Nude; Monophenol Monooxygenase; Neuroblastoma; Tamoxifen; Tumor Cells, Cultured | 1991 |
Hydrogen peroxide as a mediator of programmed cell death in the blastocyst.
Topics: Animals; Antimetabolites; Blastocyst; Buthionine Sulfoximine; Catalase; Cell Survival; Disease Models, Animal; Glutathione; Hydrogen Peroxide; In Vitro Techniques; Methionine Sulfoximine; Mice; Neoplasms, Germ Cell and Embryonal; Tumor Cells, Cultured | 1991 |
The evaluation of Escherichia coli as a model for oxidant stress in mammalian hepatocytes: role of glutathione.
Topics: Animals; Buthionine Sulfoximine; Carmustine; Escherichia coli; Glutathione; Glutathione Reductase; Hydrogen Peroxide; Liver; Methionine Sulfoximine; Models, Biological; Oxidation-Reduction; Paraquat; Peroxides; Superoxides; tert-Butylhydroperoxide | 1991 |
Enhancement of SR 2508 (etanidazole) radiosensitization by buthionine sulphoximine at low-dose-rate irradiation.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Hypoxia; Dose-Response Relationship, Radiation; Drug Combinations; Drug Synergism; Etanidazole; In Vitro Techniques; Methionine Sulfoximine; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
Relationship between glutathione content and formation of organic solvent-soluble fluorescent pigments in mice treated with chloroquine.
Topics: Acid Phosphatase; Animals; Antimetabolites; Buthionine Sulfoximine; Chloroquine; gamma-Glutamyltransferase; Glutathione; Kidney; Liver; Male; Methionine Sulfoximine; Mice; Pigments, Biological; Spectrophotometry; Starvation | 1991 |
Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cerebral Cortex; Female; Glutamates; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Methionine Sulfoximine; Mice; N-Methylaspartate; Pregnancy | 1991 |
Depletion of glutathione by L-buthionine sulfoximine does not promote inactivation of myo-inositol transport in cultured bovine lens epithelial cells.
Topics: Animals; Antimetabolites; Biological Transport, Active; Buthionine Sulfoximine; Cattle; Cells, Cultured; Dithiothreitol; Epithelial Cells; Epithelium; Galactitol; Galactose; Glutamate-Cysteine Ligase; Glutathione; Inositol; Lens, Crystalline; Methionine Sulfoximine | 1991 |
Spatial characterization of glutathione depletion in the KHT sarcoma using flow cytometry.
Topics: Animals; Buthionine Sulfoximine; Female; Glutathione; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Radiation Tolerance; Sarcoma, Experimental | 1991 |
Analytical and preparative separation of the diastereomers of L-buthionine (SR)-sulfoximine, a potent inhibitor of glutathione biosynthesis.
Topics: Animals; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Glutamate-Cysteine Ligase; Glutathione; Methionine Sulfoximine; Mice; Organ Specificity; Stereoisomerism; X-Ray Diffraction | 1991 |
Increased glutathione levels in quiescent, serum-stimulated NRK-49F cells are associated not with a response to growth factors but with nutrient repletion.
Topics: Animals; Blood; Buthionine Sulfoximine; Cell Division; Cell Line; Culture Media; Cysteine; DNA; Epidermal Growth Factor; Glutamates; Glutamic Acid; Glutathione; Growth Substances; Interphase; Methionine Sulfoximine | 1991 |
Protection against alpha-naphthylisothiocyanate-induced liver injury by decreased hepatic non-protein sulfhydryl content.
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Bile; Bile Acids and Salts; Bilirubin; Buthionine Sulfoximine; Cholestasis, Intrahepatic; gamma-Glutamyltransferase; Glutathione; Ketones; Liver; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1991 |
Combined in vitro modulation of adriamycin resistance.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Carcinoma, Small Cell; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Glutathione; Humans; Lung Neoplasms; Membrane Glycoproteins; Methionine Sulfoximine; Neoplasm Proteins; Pleural Effusion | 1991 |
Multifactorial resistance in LS174T human colon carcinoma cells selected with doxorubicin.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Division; Cell Line; Colonic Neoplasms; Doxorubicin; Drug Resistance; Flow Cytometry; Genetic Variation; Humans; Membrane Glycoproteins; Methionine Sulfoximine; Neoplasm Proteins | 1991 |
Protection from hyperbaric oxidant stress by administration of buthionine sulfoximine.
Topics: Animals; Antimetabolites; Brain Chemistry; Buthionine Sulfoximine; Diet; Free Radicals; Glutamate-Cysteine Ligase; Glutathione; Hyperbaric Oxygenation; Liver; Male; Methionine Sulfoximine; Microsomes, Liver; Oxygen; Rats; Rats, Inbred Strains; Thiobarbiturates | 1991 |
Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.
Topics: Aging; Animals; Animals, Newborn; Buthionine Sulfoximine; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Isomerism; Male; Methionine Sulfoximine; Mitochondria; Organ Specificity; Rats; Rats, Inbred Strains | 1991 |
Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Division; Cell Survival; Colonic Neoplasms; Doxorubicin; Drug Resistance; Gene Expression; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Humans; Membrane Glycoproteins; Methionine Sulfoximine; RNA, Messenger; Tumor Cells, Cultured; Verapamil | 1991 |
Acetaminophen does not induce oxidative stress in isolated rat hepatocytes: its probable antioxidant effect is potentiated by the flavonoid silybin.
Topics: Acetaminophen; Animals; Antioxidants; Buthionine Sulfoximine; Drug Synergism; Glutamate-Cysteine Ligase; Glutathione; In Vitro Techniques; Lipid Peroxidation; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Silymarin; Stress, Physiological | 1991 |
Covalent interactions of 1,2,3-trichloropropane with hepatic macromolecules: studies in the male F-344 rat.
Topics: Analysis of Variance; Animals; Antimetabolites; Benzoflavones; beta-Naphthoflavone; Buthionine Sulfoximine; DNA; Dose-Response Relationship, Drug; Liver; Male; Methionine Sulfoximine; Phenobarbital; Propane; Proteins; Pyridines; Rats; Rats, Inbred F344; RNA; Time Factors | 1990 |
The role of glutathione in lymphocyte activation--II. Effects of buthionine sulfoximine and 2-cyclohexene-1-one on early and late activation events.
Topics: Aminoisobutyric Acids; Buthionine Sulfoximine; Cyclohexanones; DNA; Glutathione; Humans; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Methionine Sulfoximine; Receptors, Interleukin-2; RNA; T-Lymphocytes | 1991 |
Hydrogen peroxide effects on ionic and non-ionic permeability of the rabbit corneal endothelium.
Topics: Amitrole; Animals; Antimetabolites; Bicarbonates; Buthionine Sulfoximine; Catalase; Dextrans; Endothelium, Corneal; Glutathione; Hydrogen Peroxide; Inulin; Methionine Sulfoximine; Permeability; Rabbits; Sodium | 1991 |
Products of the reaction of selenite with intracellular sulfhydryl compounds.
Topics: Antimetabolites; Autoradiography; Buthionine Sulfoximine; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cysteine; Glutathione; HeLa Cells; Humans; Methionine Sulfoximine; Organoselenium Compounds; Selenious Acid; Selenium; Selenium Compounds; Selenium Radioisotopes; Selenocysteine; Sulfhydryl Compounds; Sulfides | 1991 |
Effect of hydroxy substituent position on 1,4-naphthoquinone toxicity to rat hepatocytes.
Topics: Animals; Buthionine Sulfoximine; Carmustine; Cell Survival; Dicumarol; Glutathione; Liver; Male; Methionine Sulfoximine; Mitochondria, Liver; Molecular Structure; Naphthoquinones; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1991 |
Effect of selenium compounds and thiols on human mammary tumor cells.
Topics: Aged; Antimetabolites; Breast Neoplasms; Buthionine Sulfoximine; Cell Survival; Cysteine; Female; Glutathione; Glutathione Peroxidase; Humans; Mercaptoethanol; Methionine Sulfoximine; Organoselenium Compounds; Selenic Acid; Selenious Acid; Selenium; Selenium Compounds; Selenocysteine; Selenomethionine; Sodium Selenite; Sulfhydryl Compounds; Trypan Blue; Tumor Cells, Cultured | 1991 |
Inhibition of the activity of glutathione peroxidase by tertiary-butylhydroperoxide in cultured Chinese hamster cells and the role of cellular glutathione in the recovery of the activity.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Drug Interactions; Glutathione; Glutathione Peroxidase; Lung; Male; Methionine Sulfoximine; Peroxides; tert-Butylhydroperoxide | 1992 |
Cellular effects of piezoelectric versus electrohydraulic high energy shock waves.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; Cysteamine; Female; Idoxuridine; L-Lactate Dehydrogenase; Lithotripsy; Mercaptoethylamines; Methionine Sulfoximine; Ovary; Radiation-Protective Agents | 1992 |
Buthionine sulfoximine-induced cytostasis does not correlate with glutathione depletion.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblasts; Glutathione; Kidney; Methionine Sulfoximine; Osmolar Concentration | 1992 |
Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Middle Aged; Neoplasms | 1992 |
S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mortality; S-Adenosylmethionine | 1992 |
An improved model of acetaminophen-induced fulminant hepatic failure in dogs.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biopsy; Blood Glucose; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Dogs; Liver; Liver Diseases; Male; Methemoglobinemia; Methionine Sulfoximine; Pulmonary Edema; Vacuoles | 1992 |
Influence of intracellular glutathione on selenite-mediated growth inhibition of canine mammary tumor cells.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Count; Cell Division; Dose-Response Relationship, Drug; Glutathione; Mammary Neoplasms, Animal; Methionine Sulfoximine; Selenious Acid; Selenium | 1992 |
Selective modulation of glutathione in mouse brain regions and its effect on acrylamide-induced neurotoxicity.
Topics: Acrylamides; Animals; Brain; Buthionine Sulfoximine; Drug Interactions; Female; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Injections, Spinal; Liver; Maleates; Methionine Sulfoximine; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Line; Fibroblasts; Gene Expression Regulation, Enzymologic; Glutathione; Heme Oxygenase (Decyclizing); Humans; Hydrogen Peroxide; Methionine Sulfoximine; Radiation-Protective Agents; RNA, Messenger; Ultraviolet Rays | 1992 |
Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Buthionine Sulfoximine; Carmustine; Child; Drug Screening Assays, Antitumor; Drug Synergism; Female; Glioma; Glutathione; Humans; Male; Mechlorethamine; Methionine Sulfoximine; Middle Aged; Tumor Cells, Cultured | 1991 |
Effect of L-dopa methylester and glutathione depletion on murine B16BL6 melanoma growth in vitro.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Transformation, Neoplastic; Glutathione; Levodopa; Melanoma, Experimental; Methionine Sulfoximine; Mice | 1991 |
Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrier.
Topics: 2-Naphthylamine; Amino Acid Transport Systems; Animals; Azaserine; Blood-Brain Barrier; Brain; Buthionine Sulfoximine; Carrier Proteins; Diazooxonorleucine; Isoxazoles; Male; Melphalan; Methionine Sulfoximine; Nitrogen Mustard Compounds; Rats; Rats, Inbred Strains | 1991 |
Antioxidant defenses of cultured gastric cells against oxygen metabolites: role of GSH redox cycle and endogenous catalase.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Carmustine; Catalase; Cells, Cultured; Chromium; Female; Gastric Mucosa; Glucose; Glucose Oxidase; Glutathione; Glutathione Reductase; Hydrogen Peroxide; Lipid Peroxidation; Male; Maleates; Methionine Sulfoximine; Oxidation-Reduction; Oxygen; Rats; Rats, Inbred Strains | 1991 |
DNA damage induced in HT-29 colon cancer cells by exposure to 1-methyl-2-nitrosoimidazole, a reductive metabolite of 1-methyl-2-nitroimidazole.
Topics: Buthionine Sulfoximine; Colonic Neoplasms; DNA; DNA Damage; DNA, Neoplasm; Endopeptidase K; Humans; Hydrogen-Ion Concentration; Imidazoles; Methionine Sulfoximine; Nitroimidazoles; Nitroso Compounds; Oxidation-Reduction; Serine Endopeptidases; Tumor Cells, Cultured | 1991 |
Protection by cysteine esters against chemically induced pulmonary oedema.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cysteine; Cystine; DNA; Female; Fluorocarbons; Glutathione; Liver; Lung; Methionine Sulfoximine; Perfusion; Pulmonary Edema; Rats; Sulfhydryl Compounds; Time Factors | 1991 |
Depletion of glutathione interferes with induction of glycerolphosphate dehydrogenase in the brains of young rats.
Topics: Aging; Animals; Antimetabolites; Brain; Buthionine Sulfoximine; Cyclohexanones; Enzyme Induction; Glutathione; Glutathione Transferase; Glycerolphosphate Dehydrogenase; Hydrocortisone; Immunohistochemistry; Isoenzymes; Maleates; Methionine Sulfoximine; Neuroglia; Rats; Rats, Inbred Strains | 1991 |
Roles of catalase and the glutathione redox cycle in the regulation of anterior-chamber hydrogen peroxide.
Topics: Amitrole; Animals; Anterior Chamber; Anterior Eye Segment; Antimetabolites; Aqueous Humor; Ascorbic Acid; Buthionine Sulfoximine; Carmustine; Catalase; Glutathione; Glutathione Reductase; Hydrogen Peroxide; Methionine Sulfoximine; Oxidation-Reduction; Rabbits | 1991 |
Glutathione dependent metabolism and detoxification of 4-hydroxy-2-nonenal.
Topics: Aldehydes; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Glutathione; Glutathione Transferase; Inactivation, Metabolic; Kinetics; Methionine Sulfoximine | 1991 |
The effects of glutathione depletion on the biodistribution of Cu(PTSM) in rats.
Topics: Animals; Antipyrine; Buthionine Sulfoximine; Copper Radioisotopes; Glutathione; Iodine Radioisotopes; Male; Maleates; Methionine Sulfoximine; Organometallic Compounds; Radiation-Protective Agents; Rats; Rats, Inbred Strains; Thiosemicarbazones; Tissue Distribution | 1991 |
Differential sensitivities of murine melanocytes and melanoma cells to buthionine sulfoximine and anticancer drugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Glutathione; Glutathione Transferase; Melanocytes; Melanoma, Experimental; Methionine Sulfoximine; Mice; Tumor Cells, Cultured | 1991 |
Inhibition of cell colony formation by selenite: involvement of glutathione.
Topics: Buthionine Sulfoximine; Cell Division; Cell Survival; Cysteine; Dose-Response Relationship, Drug; Glutathione; HeLa Cells; Humans; In Vitro Techniques; Methionine Sulfoximine; Selenious Acid; Selenium; Selenocysteine; Sulfhydryl Compounds | 1991 |
Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity.
Topics: Acetylcholine; Amitrole; Animals; Bradykinin; Buthionine Sulfoximine; Calcimycin; Catalase; Cells, Cultured; Coronary Vessels; Ditiocarb; Endothelium, Vascular; Female; Glutathione; In Vitro Techniques; Male; Methionine Sulfoximine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Rabbits; Superoxide Dismutase; Swine; Vasodilation | 1991 |
Reversal of melphalan resistance in vivo and in vitro by modulation of glutathione metabolism.
Topics: Buthionine Sulfoximine; Cell Survival; Drug Resistance; Glutathione; Glutathione Transferase; Humans; Melphalan; Methionine Sulfoximine; Multiple Myeloma; Neoplasm Transplantation; Tumor Cells, Cultured | 1991 |
Glutathione and cellular response of ACNU-resistant rat glioma sublines to drugs and radiation.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Doxorubicin; Drug Resistance; Etoposide; Glioma; Glutathione; Kinetics; Methionine Sulfoximine; Nimustine; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Vinblastine | 1991 |
Effects of glutathione depletion on the synthesis of proteoglycan and collagen in cultured chondrocytes.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Chick Embryo; Collagen; Electrophoresis, Polyacrylamide Gel; Glucosamine; Glutathione; Glycosaminoglycans; Glycosides; Growth Plate; Kinetics; Methionine Sulfoximine; Nitrophenols; Protein Biosynthesis; Protein Processing, Post-Translational; Proteoglycans; Sulfur Oxides | 1991 |
Plasma glutathione turnover in the rat: effect of fasting and buthionine sulfoximine.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cysteine; Erythrocytes; Fasting; Glutathione; Hemolysis; In Vitro Techniques; Indicators and Reagents; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Sulfur Radioisotopes | 1991 |
Mechanism of photosensitization by microsphere-bound chlorin e6 in human bladder carcinoma cells.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Chlorophyllides; Fibroblasts; Humans; Kinetics; Light; Methionine Sulfoximine; Microspheres; Porphyrins; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms | 1991 |
Anticataractogenic property of gamma-glutamylcysteine ethyl ester in an animal model of cataract.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cataract; Dipeptides; Disease Models, Animal; Glutathione; Kidney; Lens, Crystalline; Liver; Male; Methionine Sulfoximine; Organ Culture Techniques; Rats; Rats, Inbred Strains | 1991 |
Anomalous relationship between cisplatin sensitivity and the formation and removal of platinum-DNA adducts in two human ovarian carcinoma cell lines in vitro.
Topics: Buthionine Sulfoximine; Cisplatin; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Female; Glutathione; Glutathione Transferase; Humans; Methionine Sulfoximine; Ovarian Neoplasms; Platinum; Tumor Cells, Cultured | 1991 |
Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L-methionine synthetase reduction.
Topics: Acetaminophen; Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Liver; Male; Methionine Adenosyltransferase; Methionine Sulfoximine; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1991 |
Kidney injury induced by lipid peroxide produced by vitamin E deficiency and GSH depletion in rats.
Topics: Animals; Buthionine Sulfoximine; Diet; Glutathione; Histocytochemistry; Kidney; Lipid Peroxides; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Vitamin E; Vitamin E Deficiency | 1991 |
Hepatotoxicity of eugenol and related compounds in mice depleted of glutathione: structural requirements for toxic potency.
Topics: Alanine Transaminase; Animals; Buthionine Sulfoximine; Eugenol; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Structure-Activity Relationship | 1991 |
Effect of buthionine sulfoximine on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid nephrotoxicity.
Topics: Animals; Buthionine Sulfoximine; Fungicides, Industrial; Glutathione; Kidney; Male; Methionine Sulfoximine; Rats; Rats, Inbred F344; Succinates; Succinimides | 1991 |
Regulation of endothelial cell prostaglandin synthesis by glutathione.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Dinitrochlorobenzene; Endothelium, Vascular; Glutathione; Kinetics; Maleates; Methionine Sulfoximine; Prostaglandins; Swine | 1991 |
Possible role of glutathione in chromium(VI) metabolism and toxicity in rats.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Chromates; Glutathione; Injections, Intraperitoneal; Kidney; Liver; Lung; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1991 |
Cytotoxicity of alkylating agents in isolated rat kidney proximal tubular and distal tubular cells.
Topics: 1-Propanol; Adenine Nucleotides; Alkylating Agents; Animals; Butanones; Buthionine Sulfoximine; Cell Survival; Dimethylnitrosamine; Dose-Response Relationship, Drug; Energy Metabolism; Glutathione; In Vitro Techniques; Isoxazoles; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; L-Lactate Dehydrogenase; Male; Methionine Sulfoximine; Oxygen Consumption; Propanols; Rats; Rats, Inbred F344 | 1991 |
Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells.
Topics: Animals; Antimetabolites; Blotting, Western; Buthionine Sulfoximine; Cadmium; Cadmium Chloride; Cell Line; Cricetinae; Cricetulus; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Female; Glutathione; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Kinetics; Maleates; Methionine Sulfoximine; Molecular Weight; Ovary | 1991 |
Modification of hepatic vitamin E stores in vivo. III. Vitamin E depletion by 1,2-dibromoethane may be related to initial conjugation with glutathione.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Buthionine Sulfoximine; Ethylene Dibromide; Glutathione; Kinetics; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Reference Values; Time Factors; Vitamin E | 1991 |
Single step selection of cis-diamminedichloroplatinum(II) resistant mutants from a human ovarian carcinoma cell line.
Topics: Aphidicolin; Buthionine Sulfoximine; Cell Survival; Cisplatin; Diterpenes; Drug Resistance; Female; Humans; Methionine Sulfoximine; Mutation; Ovarian Neoplasms; Phenotype; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1991 |
Enhancement of the antitumor effect of glucose oxidase by combined administration of hydrogen peroxide decomposition inhibitors together with an oxygenated fluorocarbon.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Catalase; Drug Synergism; Female; Fluorocarbons; Glucose Oxidase; Hydrogen Peroxide; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Oxygen | 1991 |
Differential effects of glutathione depletion on T cell subsets.
Topics: Animals; Buthionine Sulfoximine; CD4-CD8 Ratio; Clone Cells; DNA; Glutathione; HIV Infections; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Receptors, Interleukin-2; T-Lymphocyte Subsets | 1991 |
Oral glutathione increases tissue glutathione in vivo.
Topics: Administration, Oral; Animals; Antimetabolites; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Colorimetry; Glutathione; Kinetics; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Models, Biological; Reference Values; Tissue Distribution | 1991 |
Age-related cysteine uptake as rate-limiting in glutathione synthesis and glutathione half-life in the cultured human lens.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Buthionine Sulfoximine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Half-Life; Humans; Infant; Infant, Newborn; Lens, Crystalline; Methionine Sulfoximine; Middle Aged | 1991 |
Comparative study of intracellular glutathione content in rat lymphocyte cultures treated with 2-mercaptoethanol and interleukin-2.
Topics: Animals; Buthionine Sulfoximine; DNA; Glutathione; Interleukin-2; Lymphocytes; Male; Mercaptoethanol; Methionine Sulfoximine; Rats; Rats, Inbred F344; Thymidine | 1991 |
Buthionine sulfoximine induced growth inhibition in human lung carcinoma cells does not correlate with glutathione depletion.
Topics: Buthionine Sulfoximine; Cell Division; Cell Survival; DNA, Neoplasm; Flow Cytometry; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Microscopy, Electron; Tumor Cells, Cultured | 1991 |
Cellular thiols in rat liver cell lines possessing different growth characteristics.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Line; Glutathione; Liver; Methionine Sulfoximine; Molecular Weight; Rats; Sulfhydryl Compounds | 1991 |
Renal selective N-acetyl-L-gamma-glutamyl prodrugs. III. N-acetyl-L-gamma-glutamyl-4'-aminowarfarin is not targeted to the kidney but is selectively excreted into the bile.
Topics: Animals; Bile; Buthionine Sulfoximine; Indocyanine Green; Kidney; Liver; Male; Methionine Sulfoximine; Organ Specificity; Probenecid; Prodrugs; Protein Binding; Rats; Rats, Inbred Strains; Tissue Distribution; Vitamin K; Warfarin | 1991 |
Evidence for stimulated glutathione synthesis by phenobarbital pretreatment during an oxidative challenge in isolated hepatocytes.
Topics: Animals; Buthionine Sulfoximine; Carmustine; Glutathione; Glutathione Reductase; Homeostasis; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Trypan Blue; Vitamin K | 1991 |
The effect of in vivo glutathione depletion with buthionine sulfoximine on rat embryo development.
Topics: Animals; Buthionine Sulfoximine; Embryo, Mammalian; Embryonic and Fetal Development; Female; Gestational Age; Glutathione; Methionine Sulfoximine; Pregnancy; Pregnancy Outcome; Rats; Rats, Inbred Strains; Teratogens | 1991 |
Circumvention of drug resistance in cisplatin-resistant sublines of the human squamous carcinoma cell line HLac 79 in vitro and in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Aphidicolin; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Cisplatin; Cyclosporins; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Female; Glutathione; Head and Neck Neoplasms; Humans; Methionine Sulfoximine; Mice; Mice, Nude; Tumor Cells, Cultured; Verapamil | 1991 |
Effects of mercuric chloride on renal plasma membrane function after depletion or elevation of renal glutathione.
Topics: Animals; Basement Membrane; Biological Transport; Buthionine Sulfoximine; Cell Membrane; Drug Synergism; Glucose; Glutathione; Kidney; Male; Maleates; Mercuric Chloride; Methionine Sulfoximine; p-Aminohippuric Acid; Rats; Rats, Inbred Strains | 1991 |
Enalapril cytotoxicity in primary cultures of rat hepatocytes. II. Role of glutathione.
Topics: Acetylcysteine; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Drug Synergism; Enalapril; Glutathione; Glutathione Reductase; Glutathione Transferase; L-Lactate Dehydrogenase; Liver; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred F344 | 1991 |
Morphological sequelae of intracameral hydrogen peroxide after inhibition of glutathione synthesis.
Topics: Amitrole; Animals; Antimetabolites; Aqueous Humor; Buthionine Sulfoximine; Catalase; Endothelium, Corneal; Glutathione; Hydrogen Peroxide; Injections, Intravenous; Methionine Sulfoximine; Oxidation-Reduction; Rabbits; Vitreous Body | 1991 |
Development of mechanisms of protection against oxidative stress in doxorubicin-resistant rat tumoral cells in culture.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Free Radicals; Glioblastoma; Glutathione; Lipid Peroxidation; Liver Neoplasms, Experimental; Membrane Glycoproteins; Methionine Sulfoximine; Oxidation-Reduction; Rats; Tumor Cells, Cultured; Vitamin E | 1990 |
The effect of doxorubicin on the glutathione content and viability of cultured human lung cancer cell lines A549 and GLC4 210.
Topics: Adenocarcinoma; Buthionine Sulfoximine; Carcinoma, Small Cell; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Doxorubicin; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Tumor Cells, Cultured | 1990 |
Conditions for maximizing and inhibiting synthesis of glutathione in cultured rat lenses: an application of HPLC with radioisotope detection.
Topics: Animals; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Culture Techniques; Cysteine; Glutamate-Cysteine Ligase; Glutathione; Lens, Crystalline; Male; Methionine Sulfoximine; Methods; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Sulfur Radioisotopes | 1990 |
Renal selective N-acetyl-gamma-glutamyl prodrugs. II. Carrier-mediated transport and intracellular conversion as determinants in the renal selectivity of N-acetyl-gamma-glutamyl sulfamethoxazole.
Topics: Animals; Antimetabolites; Biological Transport, Active; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Drug Interactions; gamma-Glutamyltransferase; Half-Life; Injections, Intravenous; Isoxazoles; Kidney; Liver; Male; Metabolic Clearance Rate; Methionine Sulfoximine; Prodrugs; Rats; Rats, Inbred Strains; Sulfamethoxazole; Tissue Distribution | 1990 |
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Buthionine Sulfoximine; CD2 Antigens; CD3 Complex; Diglycerides; DNA Replication; Glutathione; Humans; In Vitro Techniques; Ionomycin; Lymphocyte Activation; Membrane Glycoproteins; Methionine Sulfoximine; Receptors, Antigen, T-Cell; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes | 1990 |
Mechanisms and modulation of multidrug resistance in primary human renal cell carcinoma.
Topics: Antimetabolites; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Carboplatin; Carcinoma, Renal Cell; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Glutathione; Humans; In Vitro Techniques; Kidney Neoplasms; Membrane Glycoproteins; Methionine Sulfoximine; Neoplasm Proteins; Organoplatinum Compounds; Oxidation-Reduction; Verapamil; Vinblastine | 1990 |
1,2-Dichloropropane (DCP) toxicity is correlated with DCP-induced glutathione (GSH) depletion and is modulated by factors affecting intracellular GSH.
Topics: 5'-Nucleotidase; Acetylcysteine; Alanine Transaminase; Alkaline Phosphatase; Animals; Antimetabolites; Aspartate Aminotransferases; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; gamma-Glutamyltransferase; Glutathione; Hemolysis; Male; Methionine Sulfoximine; Propane; Rats; Rats, Inbred Strains | 1990 |
Acetaminophen toxicity to cultured rat embryos.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Culture Techniques; Female; Glutathione; Macaca mulatta; Maternal-Fetal Exchange; Methionine Sulfoximine; Pregnancy; Rats; Rats, Inbred Strains; Teratogens | 1990 |
Effect of buthionine sulfoximine on toxicity of verapamil and doxorubicin to multidrug resistant cells and to mice.
Topics: Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Flupenthixol; Glutathione; Methionine Sulfoximine; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Verapamil | 1991 |
Development and characterization of a melphalan-resistant human multiple myeloma cell line.
Topics: Alkylating Agents; Buthionine Sulfoximine; Cell Survival; DNA, Neoplasm; Drug Resistance; Glutathione; Humans; Karyotyping; Melphalan; Methionine Sulfoximine; Multiple Myeloma; Myeloma Proteins; Tumor Cells, Cultured | 1991 |
Glutathione diminishes the anti-tumour activity of 4-hydroperoxycyclophosphamide by stabilising its spontaneous breakdown to alkylating metabolites.
Topics: Alkylating Agents; Animals; Antimetabolites; Buthionine Sulfoximine; Cyclophosphamide; Drug Synergism; Female; Glutathione; Humans; Intracellular Fluid; Kinetics; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Ovarian Neoplasms; Tumor Cells, Cultured | 1991 |
Modification of hepatic vitamin E stores in vivo. I. Alterations in plasma and liver vitamin E content by methyl ethyl ketone peroxide.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Butanones; Buthionine Sulfoximine; Glutathione; Lipid Peroxidation; Liver; Male; Methionine Sulfoximine; Peroxides; Rats; Rats, Inbred Strains; Vitamin E | 1991 |
Changes in glutathione concentration in hypothermically perfused dog kidneys.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cold Temperature; Dithionitrobenzoic Acid; Dogs; Glutathione; Glutathione Disulfide; Kidney; Methionine Sulfoximine; Organ Preservation; Osmolar Concentration; Perfusion; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Time Factors; Tissue Distribution | 1991 |
Tissue-specific changes in glutathione and cysteine after buthionine sulfoximine treatment of rats and the potential for artifacts in thiol levels resulting from tissue preparation.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cysteine; Dose-Response Relationship, Drug; Glutathione; Injections, Intraperitoneal; Kidney; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Spectrophotometry; Sulfhydryl Compounds; Time Factors | 1991 |
Modulation of glutathione content and the effect on methionine auxotrophy and cellular distribution of homocysteine and cysteine in mouse cell lines.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Division; Cell Line; Culture Media; Cystamine; Cysteamine; Cysteine; Fibroblasts; Glutathione; Homocysteine; Intracellular Fluid; Leukemia, Experimental; Methionine; Methionine Sulfoximine; Mice | 1991 |
Glutathione depletion in human and in rat multi-drug resistant breast cancer cell lines.
Topics: Animals; Breast Neoplasms; Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Female; Glutathione; Glutathione Transferase; Humans; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Rats; Rats, Inbred F344; Tumor Cells, Cultured; Verapamil | 1991 |
The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells.
Topics: Buthionine Sulfoximine; Cell Nucleus; Drug Resistance; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured | 1991 |
Intercellular transfer of drug resistance.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Communication; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; DNA; DNA Damage; Drug Resistance; Female; Flow Cytometry; Glutathione; Humans; In Vitro Techniques; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Glutathione deficiency leads to mitochondrial damage in brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Buthionine Sulfoximine; Female; Glutathione; Glutathione Disulfide; Male; Methionine Sulfoximine; Microscopy, Electron; Mitochondria; Mitochondrial Swelling; Rats; Rats, Inbred Strains | 1991 |
Depletion of glutathione after gamma irradiation modifies survival.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Gamma Rays; Glutathione; Maleates; Methionine Sulfoximine | 1991 |
Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers.
Topics: Alkylating Agents; Animals; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma 256, Walker; Carmustine; Cell Division; Cell Line; Chlorambucil; Cisplatin; Drug Antagonism; Drug Resistance; Glutathione Transferase; Gossypol; Humans; In Vitro Techniques; Isomerism; Melphalan; Methionine Sulfoximine; Rats | 1991 |
Glutathione modulates activation-dependent proliferation of human peripheral blood lymphocyte populations without regulating their activated function.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Division; Glutathione; Humans; In Vitro Techniques; Interleukin-2; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lymphocyte Activation; Lymphocytes; Mercaptoethanol; Methionine Sulfoximine; T-Lymphocytes | 1991 |
Changes in glutathione and cellular energy as potential mechanisms of papaverine-induced hepatotoxicity in vitro.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Buthionine Sulfoximine; Cells, Cultured; Energy Metabolism; Glutathione; Imidazoles; Lipid Peroxidation; Liver; Methionine Sulfoximine; Papaverine; Pyridines; Rats; Rats, Inbred Strains | 1991 |
The site specificity and sensitivity of the rat liver to butylated hydroxytoluene-induced damage.
Topics: Animals; Blood Proteins; Buthionine Sulfoximine; Butylated Hydroxytoluene; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Isoenzymes; Liver; Male; Methionine Sulfoximine; Oxidoreductases; Rats; Rats, Inbred Strains | 1991 |
Cadmium inhibits EGF-induced DNA synthesis but increases cellular glutathione levels in NRK-49F cells.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cadmium; Cells, Cultured; DNA; Epidermal Growth Factor; Fibroblasts; Glutathione; Kidney; Methionine Sulfoximine; Rats; Thymidine; Tritium | 1991 |
Role of glutathione and hsp 70 in the acquisition of thermotolerance in postimplantation rat embryos.
Topics: Animals; Blotting, Northern; Buthionine Sulfoximine; DNA; Embryo, Mammalian; Embryonic and Fetal Development; Gene Expression Regulation; Glutathione; Heat-Shock Proteins; Hot Temperature; Methionine Sulfoximine; Organ Culture Techniques; Rats; Rats, Inbred Strains; RNA, Messenger | 1991 |
Effect of modulators of glutathione synthesis on the hepatotoxicity of 2-methylfuran.
Topics: Alanine Transaminase; Animals; Antimetabolites; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cystine; Drug Interactions; Furans; Glutathione; Male; Maleates; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1991 |
Role of glutathione in the in vitro synergism between 4-hydroperoxy-cyclophosphamide and cisplatin in leukemia cell lines.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Cisplatin; Cyclophosphamide; Drug Screening Assays, Antitumor; Drug Synergism; Glutathione; Humans; Kinetics; Leukemia; Leukemia, Experimental; Methionine Sulfoximine | 1991 |
The effect of glutathione depletion by buthionine sulphoximine on 1-cyano-3,4-epithiobutane toxicity.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Karyometry; Kidney; Liver; Male; Methionine Sulfoximine; Nitriles; Rats; Rats, Inbred F344 | 1991 |
Rapid deterioration of lens fibers in GSH-depleted mouse pups.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cataract; Dose-Response Relationship, Drug; Female; Glutathione; Lens, Crystalline; Male; Methionine Sulfoximine; Mice; Mitochondria | 1991 |
Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine.
Topics: Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Buthionine Sulfoximine; Drug Synergism; Glutathione; Intestines; Kidney; Liver; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Nude; Muscles; Time Factors; Weight Loss | 1991 |
Differential in vitro sensitivity of human tumor and normal cells to chemotherapeutic agents and resistance modulators.
Topics: Adenocarcinoma; Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cell Line; Cell Survival; Cisplatin; Cyclosporins; Doxorubicin; Drug Screening Assays, Antitumor; Etoposide; Humans; Kidney Neoplasms; Kinetics; Leukemia; Lymphocytes; Methionine Sulfoximine; Neurilemmoma; Tumor Cells, Cultured; Verapamil; Vincristine | 1991 |
Effect of glutathione depletion on sunburn cell formation in the hairless mouse.
Topics: Animals; Buthionine Sulfoximine; Cell Count; Epidermis; Female; Glutathione; Methionine Sulfoximine; Mice; Mice, Hairless; Sunburn; Ultraviolet Rays | 1991 |
Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine.
Topics: Alanine Transaminase; Animals; Antimetabolites; Benzoflavones; beta-Naphthoflavone; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Eugenol; Glutathione; Liver; Liver Circulation; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Organ Size; Phenobarbital | 1991 |
Effect of glutathione depletion on the in vivo inhibition of drug metabolism by agents forming an inactive cytochrome P-450 Fe(II):metabolite complex. Studies with amiodarone and troleandomycin.
Topics: Amiodarone; Animals; Antimetabolites; Antipyrine; Buthionine Sulfoximine; Cytochrome P-450 Enzyme System; Glutathione; Liver; Male; Maleates; Methionine Sulfoximine; Pharmaceutical Preparations; Rats; Rats, Inbred Strains; Troleandomycin | 1991 |
Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Brain; Buthionine Sulfoximine; Female; Glutathione; Kidney; Liver; Lung; Male; Methionine Sulfoximine; Microscopy, Electron; Mitochondria; Models, Biological; Organ Specificity; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Involvement of diminution of glutathione, produced by deficiency of methionine in the diet, in the elevation of malic enzyme level in rat liver.
Topics: Amino Acids, Essential; Animals; Buthionine Sulfoximine; Dietary Proteins; Enzyme Induction; Female; Glutathione; Glutathione Reductase; Liver; Malate Dehydrogenase; Methionine; Methionine Sulfoximine; NADH Dehydrogenase; Rats; Rats, Inbred Strains | 1991 |
Comparison of the cytotoxicity of different hydroperoxides to V79 cells.
Topics: Aminoquinolines; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Colony-Forming Units Assay; Free Radicals; Hydrogen Peroxide; Lipid Peroxides; Masoprocol; Methionine Sulfoximine; Peroxides; Phenanthrolines; tert-Butylhydroperoxide | 1991 |
Modulation of genotoxicity of azathioprine by intracellular glutathione in hepatocytes.
Topics: Animals; Antimetabolites; Azathioprine; Buthionine Sulfoximine; DNA; Glutathione; Intracellular Fluid; Liver; Male; Methionine; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1991 |
The possible role of glutathione on the hepatotoxic effect of papaverine hydrochloride in vitro.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Glutathione; Lipid Peroxidation; Liver; Methionine Sulfoximine; Papaverine | 1991 |
Role of glutathione in the regulation of anterior chamber hydrogen peroxide.
Topics: Amitrole; Animals; Anterior Chamber; Antimetabolites; Buthionine Sulfoximine; Carmustine; Catalase; Ciliary Body; Glutathione; Glutathione Reductase; Hydrogen Peroxide; Iris; Methionine Sulfoximine; Oxidation-Reduction; Rabbits | 1990 |
L-buthionine sulfoximine-induced loss of glutathione does not elicit PGH synthase inactivation in cultured bovine lens epithelial cells.
Topics: Aldehyde Reductase; Animals; Antimetabolites; Buthionine Sulfoximine; Cattle; Cells, Cultured; Culture Media; Enzyme Activation; Epithelial Cells; Galactose; Glutathione; Intracellular Fluid; Lens Capsule, Crystalline; Lens, Crystalline; Methionine Sulfoximine; Polymers; Prostaglandin-Endoperoxide Synthases | 1990 |
The importance of glutathione and glutathione transferase for somatic mutations in Drosophila melanogaster induced in vivo by 1,2-dichloroethane.
Topics: Aflatoxins; Animals; Buthionine Sulfoximine; Drosophila melanogaster; Ethylene Dichlorides; Female; Glutathione; Glutathione Transferase; Hydrocarbons, Chlorinated; Male; Methionine Sulfoximine; Mutation; Phenobarbital | 1990 |
Cholesterol synthesis in patients with glutathione deficiency.
Topics: Buthionine Sulfoximine; Cholesterol; Female; Fibroblasts; Glutathione; Glutathione Disulfide; Humans; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Male; Methionine Sulfoximine | 1990 |
In vitro investigations on induction and reversal of cisplatin resistance in a rat ovarian tumor cell line.
Topics: Animals; Antimetabolites; Benzamides; Buthionine Sulfoximine; Cell Line; Cisplatin; DNA; Drug Resistance; Female; Glutathione; Glutathione Disulfide; In Vitro Techniques; Methionine Sulfoximine; Ovarian Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Rats | 1990 |
Induction of rat UDP-glucuronosyltransferase and glutathione S-transferase activities by L-buthionine-S,R-sulfoximine without induction of cytochrome P-450.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Glutathione; Glutathione Transferase; Male; Methionine Sulfoximine; Microsomes, Liver; Rats; Rats, Inbred Strains | 1990 |
Glutathione depletion and cytotoxicity of buthionine sulphoximine and SR2508 in rodent and human cells.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Drug Synergism; Etanidazole; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Nitroimidazoles; Radiation-Sensitizing Agents | 1990 |
Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat.
Topics: Aminophenols; Animals; Antimetabolites; Biliary Tract; Buthionine Sulfoximine; Catheterization; Glutathione; Kidney; Kidney Diseases; Liver; Magnetic Resonance Spectroscopy; Male; Methionine Sulfoximine; Protons; Rats; Rats, Inbred F344 | 1990 |
In vivo thiyl free radical formation from hemoglobin following administration of hydroperoxides.
Topics: Animals; Buthionine Sulfoximine; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Free Radicals; Glutathione; Hemoglobins; Iodoacetamide; Male; Maleates; Methionine Sulfoximine; Peroxides; Rats; Rats, Inbred Strains; Spin Labels; Sulfides; tert-Butylhydroperoxide | 1990 |
Long-term buthionine-sulfoximine-mediated toxicity in cultured hepatoma cell lines.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Survival; Female; Glutathione; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Methionine Sulfoximine; Neoplasm Proteins; Time Factors; Tumor Cells, Cultured | 1990 |
Reduction in vitro of red cell glutathione reproduces defects of cellular sodium transport seen in oedematous malnutrition.
Topics: Adult; Antimetabolites; Buthionine Sulfoximine; Carmustine; Erythrocyte Membrane; Erythrocytes; Glutathione; Humans; In Vitro Techniques; Kwashiorkor; Male; Methionine Sulfoximine; Protein-Energy Malnutrition; Sodium; Sodium Channels | 1990 |
Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor necrosis factor.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cattle; Glutathione; Humans; Hydroxides; Hydroxyl Radical; Intracellular Fluid; Maleates; Methionine Sulfoximine; Mice; Neoplasms, Experimental; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Effect of inhibition of glutathione synthesis on the immunogenicity of captopril and captopril-protein conjugates in the mouse.
Topics: Animals; Antibody Formation; Antimetabolites; Buthionine Sulfoximine; Captopril; Glutathione; Immunoglobulin G; Injections, Intraperitoneal; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Penicillamine | 1990 |
Hepatotoxicity of geniposide in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Buthionine Sulfoximine; Chloramphenicol; Cysteine; Injections, Intraperitoneal; Iridoid Glycosides; Iridoids; Liver; Male; Methionine Sulfoximine; Molecular Structure; Pyrans; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1990 |
Bioavailability of dietary glutathione: effect on plasma concentration.
Topics: Amino Acids; Animals; Antimetabolites; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Diet; Glutathione; Intestinal Absorption; Isoxazoles; Kinetics; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Time Factors | 1990 |
Schedule dependence of buthionine sulfoximine in reversing resistance to cisplatin.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Transformation, Neoplastic; Cisplatin; Colonic Neoplasms; Cross-Linking Reagents; DNA; Drug Resistance; Glutathione; Humans; Methionine Sulfoximine; Tumor Cells, Cultured | 1990 |
Cellular glutathione as a protective agent against 4-hydroperoxycyclophosphamide cytotoxicity in K-562 cells.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Line; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methionine Sulfoximine; Sulfhydryl Compounds; Tumor Cells, Cultured | 1990 |
Protection against cisplatin toxicity by administration of glutathione ester.
Topics: Animals; Blood Urea Nitrogen; Buthionine Sulfoximine; Cisplatin; Creatinine; Glutathione; Kidney; Kidney Diseases; Liver; Male; Methionine Sulfoximine; Mice | 1990 |
Effects of glutathione depletion, chelation and diuresis on iron nitrilotriacetate-induced lipid peroxidation in rats and mice.
Topics: Animals; Buthionine Sulfoximine; Chelating Agents; Deferoxamine; Diuretics; Ferric Compounds; Furosemide; Glutathione; Kidney; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine Sulfoximine; Nitrilotriacetic Acid; Oxidation-Reduction; Rats; Rats, Inbred Strains; Species Specificity | 1990 |
On the metallothionein, glutathione and cysteine relationship in rat liver.
Topics: Animals; Body Weight; Buthionine Sulfoximine; Cysteine; Glutathione; Isoxazoles; Liver; Male; Metallothionein; Methionine Sulfoximine; Organ Size; Rats; Rats, Inbred Strains; Starvation; Stress, Physiological; Zinc | 1990 |
Cysteine and glutathione metabolism in organ-cultured rat corneas.
Topics: Animals; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cornea; Cysteine; Glutathione; Half-Life; Male; Mercaptoethanol; Methionine Sulfoximine; Organ Culture Techniques; Oxygen Consumption; Rats; Rats, Inbred Strains | 1990 |
Enhancement of melphalan (L-PAM) toxicity by reductive metabolites of 1-methyl-2-nitroimidazole, a model nitroimidazole chemosensitizing agent.
Topics: Buthionine Sulfoximine; Cell Survival; Drug Synergism; Glutathione; Humans; In Vitro Techniques; Melphalan; Methionine Sulfoximine; Nitroimidazoles; Oxidation-Reduction; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Effective depletion of glutathione in rat striatum and substantia nigra by L-buthionine sulfoximine in combination with 2-cyclohexene-1-one.
Topics: Animals; Buthionine Sulfoximine; Corpus Striatum; Cyclohexanones; Glutathione; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Substantia Nigra | 1990 |
Lack of effect of glutathione depletion by L-buthionine-S,R-sulfoximine on gentamicin nephrotoxicity in rats.
Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Antimetabolites; Buthionine Sulfoximine; Creatinine; Dose-Response Relationship, Drug; Gentamicins; Glutathione; Kidney; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Male; Methionine Sulfoximine; Oxygen; Rats; Rats, Inbred Strains | 1990 |
Rate of buthionine sulfoximine entry into brain and xenotransplanted human gliomas.
Topics: Animals; Brain; Brain Neoplasms; Buthionine Sulfoximine; Capillaries; Diffusion; Glioma; Humans; Methionine Sulfoximine; Mice; Mice, Nude; Transplantation, Heterologous | 1990 |
Glutathione content and growth in A549 human lung carcinoma cells.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Division; Cell Line; Glutathione; Humans; Kinetics; Lung Neoplasms; Methionine Sulfoximine; Time Factors; Tumor Cells, Cultured | 1990 |
Intracellular glutathione in the protection from anoxic injury in renal proximal tubules.
Topics: Adenosine Triphosphate; Animals; Buthionine Sulfoximine; Cysteine; Female; Glutathione; Glycine; In Vitro Techniques; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Methionine Sulfoximine; Oxygen; Oxygen Consumption; Potassium; Rabbits | 1990 |
Nuclear thiols: technical limitations on the determination of endogenous nuclear glutathione and the potential importance of sulfhydryl proteins.
Topics: Animals; Bridged Bicyclo Compounds; Buthionine Sulfoximine; Cell Line; Cell Nucleus; Chromatography, High Pressure Liquid; Cytoplasm; Female; Glutathione; In Vitro Techniques; Indicators and Reagents; Methionine Sulfoximine | 1990 |
Growth state dependent increase of glutathione by homocysteine and other thiols, and homocysteine formation in glutathione depleted mouse cell lines.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Line; Cysteamine; Disulfides; Dithioerythritol; Glutathione; Homocysteine; Mercaptoethanol; Methionine Sulfoximine; Mice; Sulfhydryl Compounds; Tumor Cells, Cultured | 1990 |
Anthracycline resistance in murine leukemic P388 cells. Role of drug efflux and glutathione related enzymes.
Topics: Animals; Antimetabolites; Biological Transport, Active; Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Interphase; Leukemia P388; Leukemia, Experimental; Methionine Sulfoximine; Mice; Trifluoperazine; Tumor Cells, Cultured | 1990 |
Enhanced in vitro cytotoxicity of 1,3-bis-(2-chloroethyl)-1-nitrosourea or buthionine sulfoximine combined with a reactive oxygen-generating enzyme immunotoxin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Carmustine; Cell Survival; Cells, Cultured; Drug Synergism; Glucose Oxidase; Glutathione; Humans; Immunotoxins; Lactoperoxidase; Lymphoma; Methionine Sulfoximine; T-Lymphocytes | 1990 |
Conjugation of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Biological Transport; Biotransformation; Buthionine Sulfoximine; Cell Division; Cell Line; Glutathione; Maleates; Mass Spectrometry; Methionine Sulfoximine; Prostaglandin D2; Tritium | 1990 |
The effect of glutathione depletion on sister-chromatid exchange induction by cytostatic drugs.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cyclophosphamide; Doxorubicin; Glutathione; Methionine Sulfoximine; Sister Chromatid Exchange | 1990 |
L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Glioma; Male; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Radiation-Sensitizing Agents | 1990 |
Effect of N-acetyl-cysteine, D-penicillamine and buthionine sulfoximine on glutathione levels and CNS oxygen toxicity in rats.
Topics: Acetylcysteine; Administration, Oral; Animals; Brain; Buthionine Sulfoximine; Drinking; Electrocardiography; Glutathione; Glutathione Peroxidase; Injections, Intraperitoneal; Male; Methionine Sulfoximine; Penicillamine; Rats; Rats, Inbred Strains | 1990 |
Glutathione is required for intestinal function.
Topics: Animals; Body Weight; Buthionine Sulfoximine; Epithelium; Female; Gastric Mucosa; Glutathione; Intestinal Mucosa; Jejunum; Methionine Sulfoximine; Mice; Muscle, Smooth; Pancreas; Reference Values | 1990 |
[Increasing chemosensitivity to cisplatin by glutathione depletion with buthionine sulfoximine. In vitro and in vivo studies with a human squamous cell cancer line].
Topics: Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Cisplatin; Colony-Forming Units Assay; Female; Glutathione; Humans; Laryngeal Neoplasms; Methionine Sulfoximine; Mice; Mice, Nude; Neoplasm Transplantation; Tumor Cells, Cultured | 1990 |
Effects of 1,3-dichloropropene on the kidney of Fisher 344 rats after pretreatment with diethyl maleate, buthionine sulfoximine, and aminooxyacetic acid.
Topics: Acetates; Acetylglucosaminidase; Allyl Compounds; Aminooxyacetic Acid; Animals; Antinematodal Agents; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Hydrocarbons, Chlorinated; Kidney; Male; Maleates; Methionine Sulfoximine; Phosphorus; Proteins; Rats; Rats, Inbred F344 | 1990 |
Organ-selective switching of 3-methylindole toxicity by glutathione depletion.
Topics: Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Glutathione; Indoles; Kidney; Liver; Lung; Male; Methionine Sulfoximine; Mice; Organ Specificity; Protein Binding; Skatole | 1990 |
Effect of DL-buthionine-S,R-sulfoximine on 1,2-dimethyl-hydrazine-induced colonic tumors in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Buthionine Sulfoximine; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Glutathione; Intestinal Mucosa; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1990 |
Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity.
Topics: Animals; Buthionine Sulfoximine; Cyclophosphamide; Dose-Response Relationship, Drug; Electrocardiography; Female; Glutathione; Heart; Male; Methionine Sulfoximine; Mice; Mice, Nude; Muscles; Myocardium; Phosphoramide Mustards; Rats; Rats, Inbred F344 | 1990 |
Growth-associated modifications of low-molecular-weight thiols and protein sulfhydryls in human bronchial fibroblasts.
Topics: Bronchi; Buthionine Sulfoximine; Cell Division; Cells, Cultured; Contact Inhibition; Culture Media; Cystine; Fibroblasts; Glutathione; Humans; Methionine Sulfoximine; Oxidation-Reduction; Proteins; Sulfhydryl Compounds | 1990 |
[Augmentation of TNF- and lymphotoxin-mediated cytotoxic effect in the combined use of ACNU and involvement of oxygen free radicals].
Topics: Animals; Buthionine Sulfoximine; Drug Screening Assays, Antitumor; Drug Synergism; Free Radicals; Glutathione; Glutathione Reductase; Lymphotoxin-alpha; Methionine Sulfoximine; Mice; Nimustine; Oxygen; Recombinant Proteins; Sarcoma, Experimental; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Chemotactic activity for human PMN generated during ethanol metabolism by rat hepatocytes: role of glutathione and glutathione peroxidase.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Chemotaxis, Leukocyte; Cytosol; Ethanol; Glutathione; Glutathione Peroxidase; Humans; Kinetics; Liver; Male; Methionine Sulfoximine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rats; Selenium | 1990 |
Enhancement of cisplatin toxicity by buthionine sulfoximine, a glutathione-depleting agent, in mice.
Topics: Animals; Antimetabolites; Blood Urea Nitrogen; Buthionine Sulfoximine; Cisplatin; Drug Interactions; Glutathione; Kidney Diseases; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains | 1990 |
Effects of phorone and/or buthionine sulfoximine on teratogenicity of 5-fluorouracil in mice.
Topics: Animals; Buthionine Sulfoximine; Drug Interactions; Female; Fluorouracil; Glutathione; Ketones; Limb Deformities, Congenital; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Pregnancy; Teratogens | 1990 |
Involvement of phytochelatins in NiCl2-triggered protection against induction of chromatid aberrations by TEM and MH in Vicia faba root tip meristems?
Topics: Buthionine Sulfoximine; Cell Division; Chromosome Aberrations; Drug Interactions; Fabaceae; Maleic Hydrazide; Methionine Sulfoximine; Nickel; Plant Proteins; Plants, Medicinal; Pyridazines; Sulfhydryl Compounds; Triethylenemelamine | 1990 |
Promotion of trans-platinum in vivo effects on renal heme and hemoprotein metabolism by D,L-buthionine-S,R-sulfoximine. Possible role of glutathione.
Topics: Animals; Buthionine Sulfoximine; Cytochrome P-450 Enzyme System; Drug Synergism; Glutathione; Heme Oxygenase (Decyclizing); Kidney; Male; Methionine Sulfoximine; Organoplatinum Compounds; Platinum; Porphyrins; Rats; Rats, Inbred Strains; Stereoisomerism; Subcellular Fractions | 1990 |
Menthofuran-dependent and independent aspects of pulegone hepatotoxicity: roles of glutathione.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cyclohexane Monoterpenes; Drug Synergism; Glutathione; Injections, Intraperitoneal; Liver; Male; Menthol; Methionine Sulfoximine; Monoterpenes; Piperonyl Butoxide; Rats; Rats, Inbred Strains; Terpenes | 1990 |
Manipulation of oxygen radical-scavenging capacity in mice alters host sensitivity to tumor necrosis factor toxicity but does not interfere with its antitumor efficacy.
Topics: Animals; Buthionine Sulfoximine; Female; Glutathione; Humans; Liver Neoplasms; Methionine Sulfoximine; Mice; Sarcoma, Experimental; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 1990 |
Changes in glutathione content and resistance to anticancer agents in human stomach cancer cells induced by treatments with melphalan in vitro.
Topics: Buthionine Sulfoximine; Cell Cycle; Cell Survival; Drug Screening Assays, Antitumor; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Stomach Neoplasms; Time Factors; Tumor Cells, Cultured | 1990 |
The deleterious effect of buthionine sulfoximine, a glutathione-depleting agent, on the cisplatin toxicity in mice.
Topics: Animals; Buthionine Sulfoximine; Cisplatin; Drug Synergism; Glutathione; Kidney; Kidney Diseases; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains | 1990 |
Nephrotoxicity of thiabendazole in mice depleted of glutathione by treatment with DL-buthionine sulphoximine.
Topics: Animals; Buthionine Sulfoximine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Glutathione; Kidney; Kidney Diseases; Male; Methionine Sulfoximine; Mice; Oxygenases; Thiabendazole | 1990 |
Effects of L-phenylalanine mustard and L-buthionine sulfoximine on murine and human hematopoietic progenitor cells in vitro.
Topics: Animals; Buthionine Sulfoximine; Colony-Forming Units Assay; Drug Synergism; Female; Hematopoietic Stem Cells; Humans; Melphalan; Methionine Sulfoximine; Mice; Time Factors | 1990 |
Glutathione conjugation in the isolated perfused rabbit lung: the effects of carbon monoxide, buthionine sulfoximine and cibacron blue.
Topics: Administration, Inhalation; Animals; Antimetabolites; Buthionine Sulfoximine; Carbon Monoxide; Epoxy Compounds; Glutathione; Glutathione Transferase; Isoenzymes; Lung; Male; Methionine Sulfoximine; Nitrophenols; Perfusion; Protein Synthesis Inhibitors; Rabbits; Substrate Specificity; Triazines | 1990 |
Effect of buthionine sulfoximine on acute N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in Fischer 344 rats.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Kidney; Kidney Diseases; Male; Methionine Sulfoximine; Rats; Rats, Inbred F344; Succinimides; Time Factors | 1990 |
Flow cytometric analysis of DNA damage and repair in the cells resistant to alkylating agents.
Topics: Alkylating Agents; Antibodies, Monoclonal; Buthionine Sulfoximine; Cell Line; Cell Survival; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Kinetics; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured | 1990 |
Gastric mucosal injury caused by hemorrhagic shock and reperfusion: protective role of the antioxidant glutathione.
Topics: Animals; Antimetabolites; Blood Transfusion; Buthionine Sulfoximine; Gastric Mucosa; Glutathione; Ischemia; Male; Maleates; Methionine Sulfoximine; Pyloric Antrum; Rats; Rats, Inbred Strains; Reperfusion Injury; Shock, Hemorrhagic; Stomach | 1990 |
Modulation of cocaine metabolism in primary rat hepatocyte cultures: effects on irreversible binding and protein biosynthesis.
Topics: Analysis of Variance; Animals; Antimetabolites; Aroclors; Buthionine Sulfoximine; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorodiphenyl (54% Chlorine); Cocaine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Proteins; Pyridines; Rats; Rats, Inbred Strains | 1990 |
Cellular glutathione as a determinant of sensitivity to mercuric chloride toxicity. Prevention of toxicity by giving glutathione monoester.
Topics: Animals; Blood Urea Nitrogen; Buthionine Sulfoximine; Cadmium; Cadmium Chloride; Glutathione; Male; Mercuric Chloride; Methionine Sulfoximine; Mice | 1990 |
The role of glutathione in resistance to cisplatin in a human small cell lung cancer cell line.
Topics: Antimetabolites; Buthionine Sulfoximine; Carcinoma; Cell Line; Cell Nucleus; Cell Survival; Cisplatin; DNA; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Neoplasm Proteins | 1990 |
Transport into brain of buthionine sulfoximine, an inhibitor of glutathione synthesis, is facilitated by esterification and administration of dimethylsulfoxide.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Dimethyl Sulfoxide; Glutathione; Kinetics; Methionine Sulfoximine; Mice | 1990 |
Role of glutathione in vanadate reduction in young and mature rats: evidence for direct participation of glutathione in vanadate inactivation.
Topics: Aging; Anesthesia; Animals; Buthionine Sulfoximine; Diuresis; Female; Glutathione; Kidney; Kidney Function Tests; Male; Methionine Sulfoximine; Oxidation-Reduction; Rats; Rats, Inbred Strains; Vanadates | 1990 |
Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs.
Topics: Antineoplastic Agents; Bleomycin; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cisplatin; Glutathione; Humans; Lung; Lung Neoplasms; Melphalan; Methionine Sulfoximine; Neoplasms; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Zinostatin | 1986 |
Chemosensitization by buthionine sulfoximine in vivo.
Topics: Animals; Antineoplastic Agents; Bleomycin; Buthionine Sulfoximine; Cisplatin; Cyclophosphamide; Glutathione; Male; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental | 1986 |
Modifications of the effect of bleomycin in the somatic mutation and recombination test in Drosophila melanogaster.
Topics: Animals; Azides; Bleomycin; Buthionine Sulfoximine; Butylated Hydroxyanisole; Catalase; Chromosome Aberrations; Drosophila melanogaster; Enzyme Induction; Female; Free Radicals; Glutathione; Glutathione Transferase; Male; Methionine Sulfoximine; Mutagenicity Tests; Mutation; Oxygen; Recombination, Genetic; Sodium Azide; Spermatozoa; Superoxide Dismutase; Thiram | 1989 |
Influence of hydrogen peroxide on adenine uptake by iris, ciliary epithelium and corneal endothelium.
Topics: Adenine; Aging; Amitrole; Animals; Anterior Chamber; Buthionine Sulfoximine; Catalase; Ciliary Body; Endothelium, Corneal; Epithelium; Glutathione; Hydrogen Peroxide; Iris; Methionine Sulfoximine; Rabbits | 1989 |
The effects of ascorbate, 3-aminotriazole, and 1,3-bis-(2-chloroethyl)-1-nitrosourea on hydrogen peroxide levels in the rabbit aqueous humor.
Topics: Amitrole; Animals; Aqueous Humor; Ascorbic Acid; Buthionine Sulfoximine; Carmustine; Catalase; Ciliary Body; Glutathione; Glutathione Reductase; Hydrogen Peroxide; Iris; Methionine Sulfoximine; Rabbits | 1989 |
Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum.
Topics: Animals; Buthionine Sulfoximine; Corpus Striatum; Dopamine; Drug Synergism; Glutathione; Hydroxydopamines; Injections, Intraventricular; Male; Methionine Sulfoximine; Norepinephrine; Oxidation-Reduction; Oxidopamine; Rats; Rats, Inbred Strains | 1989 |
Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines.
Topics: Aphidicolin; Buthionine Sulfoximine; Centrifugation, Density Gradient; Cisplatin; Diterpenes; DNA Polymerase II; DNA Repair; Drug Resistance; Female; Glutathione; Humans; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured | 1989 |
Effects of lipoxygenase and glutathione pathway inhibitors on leukemic cell line growth.
Topics: Buthionine Sulfoximine; Caffeic Acids; Dose-Response Relationship, Drug; Glutathione; Hematopoietic Stem Cells; Humans; Leukemia; Leukotrienes; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Methionine Sulfoximine; Tumor Cells, Cultured | 1989 |
Role of lipid peroxidation in hematoporphyrin derivative-sensitized photokilling of tumor cells: protective effects of glutathione peroxidase.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Glutathione; Glutathione Peroxidase; Hematoporphyrin Derivative; Hematoporphyrins; Leukemia L1210; Lipid Peroxidation; Methionine Sulfoximine; Mice; Photochemotherapy; Selenium | 1989 |
The effect of glutathione (GSH) depletion in vivo by buthionine sulfoximine (BSO) on the radiosensitization of SR 2508.
Topics: Animals; Buthionine Sulfoximine; Etanidazole; Glutathione; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1989 |
Modification of SR 2508 sensitization in hypoxic V79 cells by manipulation of glutathione levels.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione; Methionine Sulfoximine; Nitroimidazoles; Oxygen; Pyrrolidonecarboxylic Acid; Radiation-Sensitizing Agents; Thiazoles; Thiazolidines | 1989 |
Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells.
Topics: Breast Neoplasms; Buthionine Sulfoximine; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Drug Synergism; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Methionine Sulfoximine | 1989 |
Radiosensitisation and radioprotection by BSO and WR-2721: the role of oxygenation.
Topics: Amifostine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Methionine Sulfoximine; Organothiophosphorus Compounds; Oxygen; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1989 |
The decomposition and aggregation of rat lens protein induced by selenite in vitro and in vivo.
Topics: Animals; Buthionine Sulfoximine; Cataract; Crystallins; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Selenium; Sodium Selenite; Sulfhydryl Compounds | 1989 |
Increased capacity for glutathione synthesis enhances resistance to radiation in Escherichia coli: a possible model for mammalian cell protection.
Topics: Antimetabolites; Buthionine Sulfoximine; DNA, Recombinant; Drug Resistance, Microbial; Escherichia coli; Gamma Rays; Glutamate-Cysteine Ligase; Glutathione; Glutathione Synthase; Methionine Sulfoximine; Models, Biological; Peptide Synthases; Radiation Protection; Species Specificity | 1989 |
Modulation of glutathione level in cultured human melanoma cells.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Line; Cell Survival; Cysteine; Glutathione; Humans; Melanoma; Methionine Sulfoximine; Tumor Cells, Cultured; Vitamin K | 1989 |
Metabolic changes in glutathione and metallothionein in newborn rat liver.
Topics: Alkynes; Animals; Animals, Newborn; Buthionine Sulfoximine; Cysteine; Female; gamma-Glutamyltransferase; Glutathione; Glycine; Liver; Metallothionein; Methionine Sulfoximine; Pargyline; Pregnancy; Rats; Zinc | 1989 |
Role of glutathione and dependent enzymes in anthracycline-resistant HL60/AR cells.
Topics: Antibiotics, Antineoplastic; Buthionine Sulfoximine; Cell Survival; Doxorubicin; Drug Resistance; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Humans; Leukemia, Promyelocytic, Acute; Methionine Sulfoximine; Mitochondria; Tumor Cells, Cultured | 1989 |
Glutathione metabolism at the blood-cerebrospinal fluid barrier.
Topics: Animals; Antimetabolites; Biological Transport; Blood-Brain Barrier; Buthionine Sulfoximine; Choroid Plexus; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Hepatic glutathione metabolism in mice acutely treated with lead acetate.
Topics: Amino Acids, Sulfur; Animals; Antimetabolites; Buthionine Sulfoximine; Cysteine; Glutamate-Cysteine Ligase; Glutathione; Half-Life; Injections, Intraperitoneal; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Organometallic Compounds | 1989 |
Buthionine sulfoximine inhibition of glutathione biosynthesis enhances hepatic lipid peroxidation in rats during acute ethanol intoxication.
Topics: Alcoholic Intoxication; Animals; Antimetabolites; Buthionine Sulfoximine; Glutamate-Cysteine Ligase; Glutathione; Lipid Peroxidation; Liver; Liver Function Tests; Male; Methionine Sulfoximine; Peptide Synthases; Rats; Rats, Inbred Strains | 1989 |
Role of glutathione in the susceptibility of Trypanosoma cruzi to drugs.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Diazooxonorleucine; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Methionine Sulfoximine; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1989 |
Rat kidney function related to tissue glutathione levels. Effects of different glutathione depletors.
Topics: Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Glutamate-Cysteine Ligase; Glutathione; Kidney; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1989 |
Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion.
Topics: Animals; Buthionine Sulfoximine; Drug Interactions; Drug Resistance; Female; Glutathione; Glutathione Transferase; Humans; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Rhabdomyosarcoma; Transplantation, Heterologous; Vincristine | 1989 |
Flow cytometric analysis of protein thiol groups in relation to the cell cycle and the intracellular content of glutathione in rat hepatocytes.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Buthionine Sulfoximine; Cell Cycle; Cell Line; Flow Cytometry; Glutathione; Liver; Methionine Sulfoximine; Rats; Sulfhydryl Compounds | 1989 |
Modification of cyclophosphamide-induced urotoxicity by buthionine sulfoximine and disulfiram in mice.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cyclophosphamide; Disulfiram; Glutathione; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Organ Size; Urinary Bladder; Urinary Bladder Diseases | 1989 |
Intracellular glutathione levels in human colon cancer cells naturally resistant to cross-linking agents.
Topics: Antimetabolites; Buthionine Sulfoximine; Cisplatin; Colonic Neoplasms; Cross-Linking Reagents; Drug Resistance; Glutathione; Humans; Leukemia; Methionine Sulfoximine; Nimustine; Tumor Cells, Cultured | 1989 |
Effect of systemic glutathione depletion by buthionine sulfoximine on sensitivity of murine bladder cancer to cytotoxic agents.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Carcinoma, Transitional Cell; Female; Glutathione; Kidney; Liver; Lung; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Myocardium; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1989 |
Enhanced cadmium cytotoxicity in A549 cells with reduced glutathione levels is due to neither enhanced cadmium accumulation nor reduced metallothionein synthesis.
Topics: Buthionine Sulfoximine; Cadmium; Glutathione; Humans; Lung Neoplasms; Maleates; Metallothionein; Methionine Sulfoximine; Sulfur Radioisotopes; Tumor Cells, Cultured | 1989 |
Glutathione depletion and cytotoxicity by naphthalene 1,2-oxide in isolated hepatocytes.
Topics: Animals; Biotransformation; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Glutathione; Isomerism; Kinetics; Liver; Male; Methionine Sulfoximine; Mice; Naphthalenes; Structure-Activity Relationship; Tritium | 1989 |
Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Buthionine Sulfoximine; Glutathione; Insecticides; Liver; Male; Methionine Sulfoximine; Plants; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Thiazoles; Thiazolidines | 1989 |
Relation between myocardial glutathione content and extent of ischemia-reperfusion injury.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Female; Glutathione; Male; Methionine Sulfoximine; Myocardial Reperfusion Injury; Myocardium; Swine | 1989 |
Differential effects of glutathione depletion and metallothionein induction on the induction of DNA single-strand breaks and cytotoxicity by tert-butyl hydroperoxide in cultured mammalian cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Damage; DNA Repair; DNA Replication; DNA, Single-Stranded; Glutathione; Kinetics; Lung; Metallothionein; Methionine Sulfoximine; Peroxides; tert-Butylhydroperoxide | 1989 |
[Cellular pharmacokinetics of melphalan alone or in combination on human lymphoma or lymphoblasts].
Topics: Antimetabolites; Blastomeres; Burkitt Lymphoma; Buthionine Sulfoximine; Cell Line; Etoposide; Humans; Lymphocytes; Melphalan; Methionine Sulfoximine; Verapamil | 1989 |
Glutathione metabolism in cultured Sertoli cells and spermatogenic cells from hamsters.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Glutathione; Male; Maleates; Mesocricetus; Methionine Sulfoximine; Sertoli Cells; Spermatids; Spermatocytes | 1989 |
Resistance of rat pulmonary alveolar epithelial cells to neutrophil- and oxidant-induced injury.
Topics: Amitrole; Animals; Azides; Buthionine Sulfoximine; Carmustine; Catalase; Cells, Cultured; Epithelium; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen Peroxide; Methionine Sulfoximine; Neutrophils; Oxidation-Reduction; Pulmonary Alveoli; Rats; Rats, Inbred F344 | 1989 |
Attempted modulation of disulfide antitumor activity in Balb/c mice through glutathione depletion.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Buthionine Sulfoximine; Glutathione; Mercaptopurine; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Structure-Activity Relationship; Thioguanine | 1989 |
Different mechanisms are involved in DNA damage, bacterial mutagenicity and cytotoxicity induced by 1,2-dibromo-3-chloropropane in suspensions of rat liver cells.
Topics: Animals; Biotransformation; Buthionine Sulfoximine; Cell Survival; DNA; DNA Damage; Dose-Response Relationship, Drug; Glutathione; In Vitro Techniques; Liver; Maleates; Methionine Sulfoximine; Mutagenicity Tests; Mutation; Propane; Rats; Salmonella typhimurium; Time Factors | 1989 |
Relationship between 1-chloro-2,4-dinitrobenzene-induced cytoskeletal perturbations and cellular glutathione.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cyclohexanones; Cytoskeleton; Dinitrochlorobenzene; Fluorescent Antibody Technique; Glutathione; Methionine Sulfoximine; Mice | 1989 |
Combined radiation-protective and radiation-sensitizing agents. IV: Measurement of intracellular protector concentrations.
Topics: Animals; Ascorbic Acid; Buthionine Sulfoximine; Cell Line; Coenzyme A; Cysteine; Glutathione; Methionine Sulfoximine; Misonidazole; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1989 |
Sensitivity of human melanoma cells to L-dopa and DL-buthionine (S,R)-sulfoximine.
Topics: Buthionine Sulfoximine; Cell Cycle; Cell Survival; Glutathione; Humans; Levodopa; Melanoma; Methionine Sulfoximine; Tumor Cells, Cultured | 1989 |
The effect of cimetidine, phenobarbitone and buthionine sulphoximine on the disposition of N-5-dimethyl-9-[(2-methoxy-4-methyl-sulphonylamino)phenylamino]- 4-acridinecarboxamide (CI-921) in the rabbit.
Topics: Amsacrine; Animals; Antimetabolites; Antineoplastic Agents; Buthionine Sulfoximine; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Glutathione; Male; Methionine Sulfoximine; Phenobarbital; Rabbits; Time Factors | 1989 |
Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester.
Topics: Animals; Buthionine Sulfoximine; Cattle; Cells, Cultured; Endothelium, Vascular; Glutathione; Hydrogen Peroxide; Isoxazoles; Kinetics; Methionine Sulfoximine; Pulmonary Artery; Radiation-Protective Agents | 1989 |
Unilateral depletion of testicular glutathione levels in the rat following intratesticular injections of diethylmaleate and buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Glutathione; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Testis | 1989 |
Lipid peroxidation: a possible mechanism of trichloroethylene-induced nephrotoxicity.
Topics: Animals; Blood Urea Nitrogen; Breath Tests; Buthionine Sulfoximine; Ethane; Free Radicals; Glutathione; Kidney Cortex; Lipid Peroxides; Liver; Male; Malondialdehyde; Methionine Sulfoximine; Mice; Oxygen; p-Aminohippuric Acid; Trichloroethylene | 1989 |
The effect of alpha-tocopherol and alpha-tocopheryl quinone on the radiosensitivity of thiol-depleted mammalian cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Glutathione; Methionine Sulfoximine; Radiation Tolerance; Radiation-Sensitizing Agents; Vitamin E | 1989 |
Role of glutathione in the aerobic radiation response.
Topics: Aerobiosis; Buthionine Sulfoximine; Cell Line; Cell Survival; Glutathione; Humans; Methionine Sulfoximine; Peroxides; Radiation Tolerance; tert-Butylhydroperoxide | 1989 |
Radiosensitization by misonidazole during recovery of cellular thiols following depletion by BSO or DEM.
Topics: Anaerobiosis; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Glutathione; Maleates; Methionine Sulfoximine; Misonidazole; Radiation-Sensitizing Agents | 1989 |
Effect of thiol manipulation on chemopotentiation by nitroimidazoles.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Cyclophosphamide; Drug Synergism; Glutathione; Humans; Methionine Sulfoximine; Misonidazole; Oxygen | 1989 |
Relationship between cell adenosine triphosphate and glutathione content and protection by glycine against hypoxic proximal tubule cell injury.
Topics: Adenosine Triphosphate; Animals; Buthionine Sulfoximine; Carmustine; Glutathione; Glycine; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Methionine Sulfoximine; Oxygen; Potassium; Rabbits | 1989 |
Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats.
Topics: Animals; Buthionine Sulfoximine; Cadmium; Glutathione; Kidney; Male; Metallothionein; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1989 |
Spermatogenic cell-somatic cell interactions are required for maintenance of spermatogenic cell glutathione.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Communication; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Techniques; Glutathione; Male; Methionine Sulfoximine; Sertoli Cells; Spermatids; Spermatocytes; Spermatogenesis; Spermatozoa; Testis; Xenopus laevis | 1989 |
Effects of fasting and glutathione depletors on the GSH-dependent enzyme system in the gastrointestinal mucosa of the rat.
Topics: Animals; Buthionine Sulfoximine; Fasting; Gastric Mucosa; Glutathione; Glutathione Peroxidase; Glutathione Synthase; Glutathione Transferase; Intestinal Mucosa; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1989 |
Influence of buthionine sulfoximine on the lethality of ifosfamide and ifosfamide-induced urotoxicity in mice.
Topics: Animals; Buthionine Sulfoximine; Cysteamine; Glutathione; Ifosfamide; Liver; Male; Methionine Sulfoximine; Mice; Organ Size; Urinary Bladder; Urologic Diseases | 1989 |
Cytotoxicity and glutathione depletion by 1-methyl-2-nitrosoimidazole in human colon cancer cells.
Topics: Buthionine Sulfoximine; Cell Survival; Colonic Neoplasms; Glutathione; Humans; Methionine Sulfoximine; Nitroimidazoles; Tumor Cells, Cultured | 1989 |
Influence of pH on the modification of thiols by carbamoylating agents and effects on glutathione levels in normal and neoplastic cells.
Topics: Animals; Buthionine Sulfoximine; Carbamates; Colonic Neoplasms; Cyanates; DNA, Neoplasm; Glutathione; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Liver Neoplasms, Experimental; Methionine Sulfoximine; Protein Biosynthesis; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Tumor Cells, Cultured | 1989 |
Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defects.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Kinetics; Liver; Lung; Lymphocytes; Male; Methionine Sulfoximine; Mice; Microscopy, Electron; Mitochondria; Organoids | 1989 |
Enhanced cytostatic activity of the sesquiterpene lactone eupatoriopicrin by glutathione depletion.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Female; Glutathione; Lung Neoplasms; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Sesquiterpenes; Tumor Cells, Cultured | 1989 |
Protective effect of glutathione against oxygen-induced growth inhibition of human diploid fibroblasts.
Topics: Buthionine Sulfoximine; Cell Division; Cells, Cultured; Culture Media; Fibroblasts; Glutathione; Humans; Maleates; Methionine Sulfoximine; Oxygen | 1989 |
Pharmacokinetics of buthionine sulfoximine (NSC 326231) and its effect on melphalan-induced toxicity in mice.
Topics: Administration, Oral; Animals; Buthionine Sulfoximine; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Interactions; Glutathione; Half-Life; Injections, Intravenous; Liver; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Premedication | 1989 |
Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate.
Topics: Administration, Oral; Analysis of Variance; Animals; Body Weight; Buthionine Sulfoximine; Cleft Palate; Female; Fetal Resorption; Fetal Viability; Glutathione; Infusions, Parenteral; Maleates; Methionine Sulfoximine; Mice; Phenytoin; Pregnancy; Teratogens | 1989 |
Protective role of intracellular glutathione against oxidized low density lipoprotein in cultured endothelial cells.
Topics: Animals; Antimetabolites; Aorta, Thoracic; Buthionine Sulfoximine; Cattle; Cell Survival; Cells, Cultured; Endothelium, Vascular; Fetus; Glutathione; Kinetics; Lipoproteins, LDL; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1989 |
Glutathione regulates interleukin-2 activity on cytotoxic T-cells.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Line; DNA Replication; Glutathione; Interleukin-2; Kinetics; Methionine Sulfoximine; Receptors, Interleukin-2; Recombinant Proteins; T-Lymphocytes, Cytotoxic; Thymidine | 1989 |
Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase.
Topics: Adolescent; Adult; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Cytoplasm; Glutathione; Growth Inhibitors; Humans; Interleukin-2; Interphase; Kinetics; Lymphocyte Activation; Lymphocytes; Methionine Sulfoximine; Receptors, Interleukin-2; Receptors, Transferrin; Sulfhydryl Compounds | 1989 |
Immunotoxins containing glucose oxidase and lactoperoxidase with tumoricidal properties: in vitro killing effectiveness in a mouse plasmacytoma cell model.
Topics: Animals; Bone Marrow; Buthionine Sulfoximine; Carmustine; Dose-Response Relationship, Immunologic; Drug Synergism; Glucose Oxidase; Glutathione; Immunization, Passive; Immunotherapy; Immunotoxins; Lactoperoxidase; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Peroxidases; Plasmacytoma | 1989 |
Improved use of buthionine sulfoximine to prevent cisplatin nephrotoxicity in rats.
Topics: Animals; Blood Urea Nitrogen; Buthionine Sulfoximine; Cisplatin; Dose-Response Relationship, Drug; Glutathione; Kidney; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1989 |
Intracerebroventricular administration of L-buthionine sulfoximine: a method for depleting brain glutathione.
Topics: Animals; Biogenic Amines; Brain; Buthionine Sulfoximine; Cerebral Ventricles; Chromatography, High Pressure Liquid; Glutathione; Injections, Intraventricular; Kinetics; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1989 |
Injurious effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the lethality and urotoxicity of cyclophosphamide in mice.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cyclophosphamide; Glutathione; Lethal Dose 50; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Urologic Diseases | 1989 |
Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.
Topics: Animals; Buthionine Sulfoximine; Cataract; Epithelium; Glutathione; Lens, Crystalline; Methionine Sulfoximine; Mice; Microscopy, Electron; Mitochondria; Rats; Rats, Inbred Strains; Reference Values | 1989 |
Inhibition of rat lung glutathione synthesis attenuates hypoxic pulmonary vasoconstriction and the associated leukotriene C4 production.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Hypoxia; Lung; Male; Methionine Sulfoximine; Perfusion; Pulmonary Circulation; Rats; Rats, Inbred Strains; SRS-A; Vasoconstriction | 1989 |
Effect of the glutathione-depleting agents diethylmaleate, phorone and buthionine sulfoximine on biliary copper excretion in rats.
Topics: Animals; Bile; Buthionine Sulfoximine; Copper; Glutathione; Ketones; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1989 |
Whither the modulation of platinum?
Topics: Amifostine; Antimetabolites; Buthionine Sulfoximine; Cisplatin; Ditiocarb; Humans; Methionine Sulfoximine | 1988 |
gamma-Glutamylcysteine and thiosulfate are the major low-molecular-weight thiols in halobacteria.
Topics: Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Glutamate-Cysteine Ligase; Glutathione; Halobacterium; Methionine Sulfoximine; Thiosulfates | 1985 |
Rat renal peritubular transport and metabolism of plasma [35S]glutathione.
Topics: Animals; Biological Transport; Buthionine Sulfoximine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney Tubules; Male; Methionine Sulfoximine; Microvilli; Perfusion; Rats | 1985 |
Effects of the long-term depletion of reduced glutathione in mice administered L-buthionine-S,R-sulfoximine.
Topics: Animals; Aspartate Aminotransferases; Buthionine Sulfoximine; Cytochrome P-450 Enzyme System; gamma-Glutamyltransferase; Glutathione; Liver; Lung; Male; Methionine Sulfoximine; Mice; Mixed Function Oxygenases; Oxidation-Reduction; Time Factors | 1985 |
Nutritional requirements of Plasmodium falciparum in culture. III. Further observations on essential nutrients and antimetabolites.
Topics: 4-Aminobenzoic Acid; Animals; Antimetabolites; Biotin; Buthionine Sulfoximine; Carbohydrate Metabolism; Culture Media; Dipyridamole; Folic Acid; Glutamates; Glutamic Acid; Hypoxanthine; Hypoxanthines; Isoniazid; Leucovorin; Methionine Sulfoximine; Plasmodium falciparum; Purines; Pyridoxine; Sulfonamides | 1985 |
Effects of experimentally altered glutathione levels on life span, metabolic rate, superoxide dismutase, catalase and inorganic peroxides in the adult housefly, Musca domestica.
Topics: Animals; Buthionine Sulfoximine; Catalase; Energy Metabolism; Glutathione; Houseflies; Kinetics; Life Expectancy; Methionine Sulfoximine; Peroxides; Pyrrolidonecarboxylic Acid; Superoxide Dismutase; Thiazoles; Thiazolidines | 1985 |
Intrahepatic transport and utilization of biliary glutathione and its metabolites.
Topics: Age Factors; Animals; Bile; Buthionine Sulfoximine; Dipeptidases; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Liver; Male; Methionine Sulfoximine; Rats | 1986 |
Modulation of gamma-glutamyl cycle and glutathione levels in rat mammary gland explants.
Topics: Amidohydrolases; Animals; Buthionine Sulfoximine; Culture Techniques; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Mammary Glands, Animal; Methionine Sulfoximine; Peptide Synthases; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1986 |
Mechanism of renal peritubular extraction of plasma glutathione. The catalytic activity of contralumenal gamma-glutamyltransferase is prerequisite to the apparent peritubular extraction of plasma glutathione.
Topics: Animals; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Kidney Tubules; Kinetics; Liver; Male; Methionine Sulfoximine; Muscles; Rats; Rats, Inbred Strains | 1986 |
Effect of glutathione depletion by buthionine sulfoximine on rat embryonic development in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Glutamate-Ammonia Ligase; Glutathione; Methionine Sulfoximine; Organ Culture Techniques; Pregnancy; Rats; Rats, Inbred Strains | 1987 |
Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Clone Cells; Dinitrochlorobenzene; Drug Resistance; gamma-Glutamyltransferase; Glioma; Glutathione; Glutathione Transferase; Lomustine; Mechlorethamine; Methionine Sulfoximine; Rats; Semustine | 1987 |
Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism.
Topics: Animals; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Kidney Tubules; Male; Methionine Sulfoximine; Oxazoles; Rats | 1987 |
Glutathione, a first line of defense against cadmium toxicity.
Topics: 1-Propanol; Animals; Buthionine Sulfoximine; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Glutamate-Cysteine Ligase; Glutathione; Male; Metallothionein; Methionine Sulfoximine; Mice | 1987 |
Inhibition of cisplatin-induced nephrotoxicity in rats by buthionine sulfoximine, a glutathione synthesis inhibitor.
Topics: Animals; Buthionine Sulfoximine; Carcinoma, Transitional Cell; Cisplatin; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Kidney; Kidney Diseases; Male; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Rats; Rats, Inbred Strains; Time Factors; Urinary Bladder Neoplasms | 1987 |
Depression of glutathione in male reproductive tissues and potentiation of EMS-induced germ cell mutagenesis by L-buthionine sulfoximine.
Topics: Alkylation; Animals; Buthionine Sulfoximine; Epididymis; Ethyl Methanesulfonate; Female; Genitalia, Male; Glutathione; Male; Methionine Sulfoximine; Mutation; Rats; Rats, Inbred F344; Spermatozoa; Testis; Vas Deferens | 1987 |
On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.
Topics: Animals; Binding Sites; Buthionine Sulfoximine; Catalysis; Escherichia coli; Glutamate-Cysteine Ligase; Glutathione; Kidney; Kinetics; Methionine Sulfoximine; Peptide Synthases; Rats; Sulfhydryl Compounds | 1988 |
Effects of buthionine sulfoximine on the development of ozone-induced pulmonary fibrosis.
Topics: Animals; Antimetabolites; Body Weight; Buthionine Sulfoximine; Glutamate-Cysteine Ligase; Glutathione; Lung; Male; Methionine Sulfoximine; Mice; Ozone; Pulmonary Fibrosis; Sulfhydryl Compounds | 1988 |
Use of the inhibition of enzymatic antioxidant systems in order to evaluate their physiological importance.
Topics: Amitrole; Buthionine Sulfoximine; Carmustine; Catalase; Cell Survival; Ditiocarb; Fibroblasts; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Humans; Methionine Sulfoximine; Superoxide Dismutase; Thiomalates | 1988 |
Effect of glutathione depletion on morphine toxicity in mice.
Topics: Animals; Buthionine Sulfoximine; Female; Glutathione; Kidney; Liver; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Morphine | 1989 |
Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Male; Methionine Sulfoximine; Mice; Microscopy, Electron; Mitochondria, Heart; Mitochondria, Muscle; Muscles; Muscular Diseases | 1989 |
Relation between biliary glutathione excretion and bile acid-independent bile flow.
Topics: Aminopyrine; Animals; Arsenic; Arsenites; Benzylamines; Bile; Bile Acids and Salts; Buthionine Sulfoximine; Cefamandole; Furosemide; Glutathione; Glycocholic Acid; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Nitrofurantoin; Phenobarbital; Rats; Rats, Inbred Strains; Sodium Compounds; Taurocholic Acid | 1989 |
Glutathione conjugation and induction of a 32,000 dalton stress protein.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Glutathione; Heat-Shock Proteins; Maleates; Methionine Sulfoximine; Molecular Weight | 1989 |
Anti-hypoxic effect of glutathione depletors.
Topics: Animals; Blood Glucose; Brain; Buthionine Sulfoximine; Cyclohexanes; Cyclohexanones; Glutathione; Hypoxia; Ketones; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Sulfhydryl Compounds | 1989 |
Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Drug Interactions; Female; Glioma; Glutathione; Humans; Male; Medulloblastoma; Melphalan; Methionine Sulfoximine; Mice; Mice, Nude; Neoplasm Transplantation | 1989 |
Inhibition of fibrinolysis by cellular glutathione depletion in the rabbit.
Topics: Animals; Aorta, Thoracic; Buthionine Sulfoximine; Endothelium, Vascular; Fibrinolysis; Glutathione; Injections, Intraperitoneal; Male; Maleates; Methionine Sulfoximine; Rabbits | 1989 |
Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells.
Topics: Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Humans; Isoenzymes; Methionine Sulfoximine; Multiple Myeloma; Sulfhydryl Compounds; Tumor Cells, Cultured | 1989 |
Modulation of X ray DNA damage by SR-2508 +/- buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; DNA; Drug Synergism; Etanidazole; Glutathione; In Vitro Techniques; Methionine Sulfoximine; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Enhancement in the aerobic toxicity of misonidazole and SR-2508 by buthionine sulfoximine and 4-hydroxypyrazole: the role of hydrogen peroxide.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Etanidazole; Glutathione; Humans; Hydrogen Peroxide; In Vitro Techniques; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Pyrazoles; Radiation-Sensitizing Agents | 1986 |
SR-2508 plus buthionine sulfoximine or SR-2508 alone: effects on the radiation response and the glutathione content of a human tumor xenograft.
Topics: Buthionine Sulfoximine; Cell Survival; Cysteine; Etanidazole; Glutathione; Humans; Methionine Sulfoximine; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1987 |
Is enhanced free radical flux associated with increased intracellular proteolysis?
Topics: Amitrole; Animals; Buthionine Sulfoximine; Cell Line; Cells, Cultured; Diamide; Ditiocarb; Dose-Response Relationship, Radiation; Fibroblasts; Free Radicals; Gamma Rays; Hydrolysis; Macrophages; Methionine Sulfoximine; Mice; Phenylhydrazines; Proteins; Superoxide Dismutase | 1987 |
Detection of DNA damage in individual cells by flow cytometric analysis using anti-DNA monoclonal antibody.
Topics: Alkylating Agents; Antibodies, Monoclonal; Buthionine Sulfoximine; Cell Cycle; Cell Survival; DNA Damage; DNA, Single-Stranded; Endonucleases; Flow Cytometry; HeLa Cells; Hot Temperature; Humans; Melphalan; Methionine Sulfoximine; Nitrogen Mustard Compounds; Single-Strand Specific DNA and RNA Endonucleases | 1987 |
Mechanism of spermidine cytotoxicity at 37 degrees C and 43 degrees C in Chinese hamster ovary cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Female; Glutathione; Guanidines; Hot Temperature; Methionine Sulfoximine; Ovary; Oxidation-Reduction; Spermidine; Thiourea | 1986 |
Protective effects of the glutathione redox cycle and vitamin E on cultured fibroblasts infected by Mycoplasma pneumoniae.
Topics: Buthionine Sulfoximine; Catalase; Cells, Cultured; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Humans; L-Lactate Dehydrogenase; Malondialdehyde; Methionine Sulfoximine; Mycoplasma pneumoniae; Oxidation-Reduction; Pneumonia, Mycoplasma; Vitamin E | 1986 |
Enhancement of EMT6/SF tumor cell killing by mitomycin C and cyclophosphamide following in vivo administration of buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cyclophosphamide; Drug Synergism; Glutathione; Male; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Neoplasm Transplantation; Neoplasms, Experimental | 1986 |
Effects of scavengers of reactive oxygen and radical species on cell survival following photodynamic treatment in vitro: comparison to ionizing radiation.
Topics: Animals; Buthionine Sulfoximine; Catalase; Cell Line; Cell Survival; Cricetinae; Cysteamine; Mannitol; Methionine Sulfoximine; Photochemotherapy; Radiation-Protective Agents; Superoxide Dismutase; Tryptophan | 1986 |
Induction of hepatic veno-occlusive disease in dogs.
Topics: Animals; Busulfan; Buthionine Sulfoximine; Cyclophosphamide; Disease Models, Animal; Dog Diseases; Dogs; Hepatic Veno-Occlusive Disease; Liver; Melphalan; Methionine Sulfoximine; Methotrexate; Monocrotaline; Pyrrolizidine Alkaloids; Radiation Injuries, Experimental; Radiography | 1987 |
Effects of esterase inhibitors and buthionine sulfoximine on the prevention of acetaminophen hepatotoxicity by N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Esterases; Isoflurophate; Lysine; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Nitrophenols; Organophosphorus Compounds; Phenylmethylsulfonyl Fluoride | 1987 |
Changes in the glutathione content of rat 9L cells induced by treatment with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine.
Topics: Alkylating Agents; Animals; Buthionine Sulfoximine; Carmustine; Eflornithine; Glutathione; Methionine Sulfoximine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Spermidine | 1987 |
Effects of modulation of hepatic glutathione on biotransformation and covalent binding of aflatoxin B1 to DNA in the mouse.
Topics: Aflatoxin B1; Aflatoxins; Animals; Bile; Biotransformation; Buthionine Sulfoximine; Butylated Hydroxyanisole; DNA; Epoxy Compounds; Glutathione; Glutathione Transferase; In Vitro Techniques; Liver; Male; Maleates; Methionine Sulfoximine; Mice | 1988 |
Selective enhancement of hypoxic cell killing by melphalan via thiol depletion: in vitro studies with hypoxic cell sensitizers and buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Drug Synergism; Etanidazole; Melphalan; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Sulfhydryl Compounds | 1985 |
Glutathione dependence of neocarzinostatin cytotoxicity and mutagenicity in Chinese hamster V-79 cells.
Topics: Animals; Antibiotics, Antineoplastic; Biotransformation; Buthionine Sulfoximine; Cricetinae; Cricetulus; Glutathione; Maleates; Methionine Sulfoximine; Mutagens; Zinostatin | 1985 |
Evidence for the involvement of sulfhydryl compounds in the inhibition of cellular DNA synthesis by selenite.
Topics: Buthionine Sulfoximine; Cell Nucleus; DNA; HeLa Cells; Humans; In Vitro Techniques; Maleates; Methionine Sulfoximine; Selenious Acid; Selenium; Sulfhydryl Compounds | 1988 |
Cellular glutathione levels and sensitivity to radiation and antineoplastic agents in human ovarian cancer.
Topics: Buthionine Sulfoximine; Cell Survival; Cisplatin; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured | 1988 |
Glutathione depletion in the guinea pig and its effect on the acute cochlear toxicity of ethacrynic acid.
Topics: Animals; Buthionine Sulfoximine; Cochlea; Cysteine; Ethacrynic Acid; Female; Glutathione; Guinea Pigs; Kidney; Liver; Male; Methionine Sulfoximine; Species Specificity | 1988 |
Potentiation of X ray sensitivity by combinations of sodium butyrate and buthionine sulfoximine.
Topics: Buthionine Sulfoximine; Butyrates; Butyric Acid; Cell Line; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Drug Synergism; Humans; In Vitro Techniques; Methionine Sulfoximine; Radiation-Sensitizing Agents | 1988 |
The role of glutathione in the detoxification of the insecticides methyl parathion and azinphos-methyl in the mouse.
Topics: Animals; Azinphosmethyl; Buthionine Sulfoximine; Glutathione; Inactivation, Metabolic; Insecticides; Liver; Maleates; Methionine Sulfoximine; Methyl Parathion; Mice; Parathion | 1988 |
Glutathione protects against exogenous oxidant injury to rabbit renal proximal tubules.
Topics: Adenosine Triphosphate; Animals; Buthionine Sulfoximine; Carmustine; Cell Membrane Permeability; Cell Survival; Glutathione; Kidney Tubules, Proximal; Kinetics; Lipid Peroxides; Malates; Malondialdehyde; Methionine Sulfoximine; Oxidation-Reduction; Oxygen Consumption; Peroxides; Potassium; Rabbits; tert-Butylhydroperoxide | 1988 |
Effect of an altered glutathione content on renal ischemic injury.
Topics: Adenine Nucleotides; Animals; Buthionine Sulfoximine; Constriction; Diuresis; Glomerular Filtration Rate; Glutathione; Ischemia; Kidney; Male; Methionine Sulfoximine; Mitochondria; Oxygen Consumption; Rats; Rats, Inbred Strains; Renal Artery | 1988 |
Depletion of glutathione, heat shock protein synthesis, and the development of thermotolerance in Chinese hamster ovary cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; Cricetulus; Electrophoresis, Polyacrylamide Gel; Female; Glutathione; Heat-Shock Proteins; Hot Temperature; Maleates; Methionine Sulfoximine; Molecular Weight; Ovary; Time Factors | 1988 |
Comparative hepatotoxicity and metabolism of N-methylformamide in rats and mice.
Topics: Animals; Buthionine Sulfoximine; Carbon Radioisotopes; Formamides; Glutathione; Liver; Male; Maleates; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Rats; Rats, Inbred Strains; Species Specificity; Sulfhydryl Compounds | 1988 |
Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Female; Glioma; Glutathione; Humans; Male; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Transplantation, Heterologous | 1988 |
Effects of chronic inhibition of glutathione biosynthesis on cholesterol and bile acid metabolism in rats.
Topics: Animals; Antimetabolites; Bile Acids and Salts; Body Weight; Buthionine Sulfoximine; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Feces; Glutathione; Kinetics; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Reference Values | 1988 |
The pulmonary effects of buthionine sulfoximine treatment and glutathione depletion in rats.
Topics: Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lung; Male; Methionine Sulfoximine; Osmolar Concentration; Oxygen; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1988 |
Four sulfhydryl-modifying compounds cause different structural damage but similar functional damage in murine lymphocytes.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Concanavalin A; Copper; Copper Sulfate; Ethylmaleimide; Female; Hydrogen Peroxide; Lipopolysaccharides; Lymphocyte Activation; Lymphocytes; Methionine Sulfoximine; Mice; Mice, Inbred CBA; Phenanthrolines; Sulfhydryl Compounds; Sulfhydryl Reagents | 1988 |
Contribution of methylsulfonyl metabolites of m-dichlorobenzene to the heme metabolic enzyme induction by the parent compound in rat liver.
Topics: 5-Aminolevulinate Synthetase; Animals; Buthionine Sulfoximine; Chlorobenzenes; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Sulfones; Tryptophan Oxygenase | 1988 |
Effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the selenium-induced lethality in mice.
Topics: Animals; Buthionine Sulfoximine; Cysteine; Drug Interactions; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Selenium | 1988 |
Marked reduction of rat brain glutathione following intracerebroventricular administration of the glutathione synthesis inhibitor L-buthionine sulfoximine.
Topics: Animals; Brain; Buthionine Sulfoximine; Glutathione; Injections, Intraventricular; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Effect of buthionine sulfoximine on orthophenylphenol-induced hepato- and nephrotoxic potential in male rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biphenyl Compounds; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Glutathione; Kidney; Kidney Diseases; Liver; Male; Methionine Sulfoximine; Organ Size; Rats; Rats, Inbred F344; Time Factors | 1988 |
Effect of sulphydryl drugs on paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antimetabolites; Blood Proteins; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Sulfhydryl Compounds | 1988 |
Radioprotection by glutathione esters and cysteamine in normal and glutathione-depleted mammalian cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cysteamine; Glutathione; HeLa Cells; Humans; Methionine Sulfoximine; Radiation-Protective Agents | 1988 |
Ribonucleotide reductase activity and growth of glutathione-depleted mouse leukemia L1210 cells in vitro.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cells, Cultured; Cytidine; Glutathione; Hydroxyurea; Leukemia L1210; Methionine Sulfoximine; Mice; Pyrazoles; Ribonucleotide Reductases | 1988 |
Importance of glutathione in the acquisition and maintenance of sperm nuclear decondensing activity in maturing hamster oocytes.
Topics: Animals; Buthionine Sulfoximine; Cricetinae; Disulfides; Female; Glutathione; Male; Mesocricetus; Methionine Sulfoximine; Oocytes; Spermatozoa; Zygote | 1988 |
Effect of D,L-buthionine-S,R-sulfoximine on cytotoxicity and DNA cross-linking induced by bifunctional DNA-reactive cytostatic drugs in human melanoma cells.
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cell Survival; Cross-Linking Reagents; DNA; Drug Synergism; Glutathione; Humans; Melanoma; Melphalan; Methionine Sulfoximine; Tumor Cells, Cultured | 1988 |
Glutathione is involved in the early cadmium cytotoxic response in human lung carcinoma cells.
Topics: Buthionine Sulfoximine; Cadmium; Drug Interactions; Glutathione; Humans; In Vitro Techniques; Lung Neoplasms; Methionine Sulfoximine | 1988 |
Glutathione and metallothioneins as cellular defense against cadmium toxicity in cultured Chinese hamster cells.
Topics: Acetates; Acetic Acid; Animals; Buthionine Sulfoximine; Cadmium; Cell Line; Cricetinae; Cricetulus; Fibroblasts; Glutathione; Lung; Male; Metallothionein; Methionine Sulfoximine | 1988 |
Enhanced potentiation of cisplatin cytotoxicity in human ovarian carcinoma cells by prolonged glutathione depletion.
Topics: Buthionine Sulfoximine; Cisplatin; Cystadenocarcinoma; Drug Synergism; Female; Glutathione; Humans; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured | 1988 |
Chinese hamster pleiotropic multidrug-resistant cells are not radioresistant.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cricetinae; Drug Resistance; Glutathione; Methionine Sulfoximine; Radiation Tolerance | 1988 |
Glutathione as a determinant of cellular response to doxorubicin.
Topics: Buthionine Sulfoximine; Cell Survival; Doxorubicin; Glutathione; Humans; Kinetics; Methionine Sulfoximine; Tumor Cells, Cultured | 1988 |
Inhibition of radiation-induced DNA-protein cross-link repair by glutathione depletion with L-buthionine sulfoximine.
Topics: Buthionine Sulfoximine; DNA Repair; DNA, Neoplasm; Glutathione; Humans; Methionine Sulfoximine | 1988 |
Effect of glutathione depletion on aminopyrine and formaldehyde metabolism.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Buthionine Sulfoximine; Formaldehyde; Formates; Glutathione; Ketones; Male; Maleates; Methionine Sulfoximine; Microsomes, Liver; Rats; Rats, Inbred Strains | 1988 |
Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.
Topics: Animals; Buthionine Sulfoximine; Female; Glutathione; Humans; Male; Medulloblastoma; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous; Tumor Cells, Cultured | 1988 |
Depletion of brain glutathione in preweanling mice by L-buthionine sulfoximine.
Topics: Aging; Animals; Antimetabolites; Brain; Buthionine Sulfoximine; Cerebellum; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Spinal Cord; Weaning | 1988 |
Effects of N-methylformamide on the growth, cell cycle, and glutathione status of murine TLX5 lymphoma cells.
Topics: Animals; Buthionine Sulfoximine; Cell Cycle; Cell Survival; Formamides; Glutathione; Lymphoma; Methionine Sulfoximine; Mice; Mice, Inbred CBA; Tumor Cells, Cultured | 1988 |
Toxic effects of acute glutathione depletion by buthionine sulfoximine and dimethylfumarate on murine mammary carcinoma cells.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Line; Depression, Chemical; Dimethyl Fumarate; DNA, Neoplasm; Drug Therapy, Combination; Fumarates; Glutathione; In Vitro Techniques; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Mice | 1988 |
Changes in X-ray sensitivity and glutathione content of human colon tumor cells after exposure to the differentiation-inducing agent sodium butyrate.
Topics: Buthionine Sulfoximine; Butyrates; Butyric Acid; Cell Line; Cell Survival; Colonic Neoplasms; DNA Repair; DNA, Neoplasm; Glutathione; Humans; Methionine Sulfoximine; Radiation Tolerance; Tumor Cells, Cultured | 1988 |
Glutathione contents in human and rodent tumor cells in various phases of the cell cycle.
Topics: Animals; Buthionine Sulfoximine; Cell Cycle; Cell Survival; Cricetinae; Doxorubicin; Glutathione; Humans; Methionine Sulfoximine; Mice; Tumor Cells, Cultured | 1988 |
Evidence that glutathione may determine the differential cell-cycle phase toxicity of a platinum (IV) antitumor agent.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Cycle; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Glutathione; Methionine Sulfoximine; Organoplatinum Compounds; Sulfhydryl Compounds | 1988 |
Immediate rise in intracellular calcium and glycogen phosphorylase a activities upon acetaminophen covalent binding leading to hepatotoxicity in mice.
Topics: Acetaminophen; Administration, Oral; Animals; Buthionine Sulfoximine; Calcium; Chemical and Drug Induced Liver Injury; Enzyme Activation; Glutathione; Liver Diseases; Male; Methionine Sulfoximine; Mice; Phosphorylase a; Phosphorylases; Protein Binding | 1988 |
Effects of glutathione depletion and induction of metallothioneins on the cytotoxicity of an organic hydroperoxide in cultured mammalian cells.
Topics: Animals; Buthionine Sulfoximine; Butylated Hydroxytoluene; Cell Division; Cells, Cultured; Cricetinae; Deferoxamine; DNA Damage; Glutathione; Lipid Peroxides; Male; Metallothionein; Methionine Sulfoximine; Peroxides; tert-Butylhydroperoxide | 1988 |
Role of thiols in the in-vitro methylation of inorganic arsenic by rat liver cytosol.
Topics: Animals; Arsenic; Arsenicals; Biotransformation; Buthionine Sulfoximine; Cacodylic Acid; Cytosol; Ketones; Liver; Methionine Sulfoximine; Methylation; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1988 |
Relationships between the cellular glutathione level and in vitro life span of human diploid fibroblasts.
Topics: Acetylcysteine; Antimetabolites; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Culture Media; Fibroblasts; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine | 1988 |
The glutathione status of rat kidney nuclei following administration of buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cell Nucleus; DNA; Glutathione; Kidney; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1988 |
Effect of DL-buthionine-S,R-sulfoximine on the growth of EMT6 and RIF mouse tumors.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Female; Glutathione; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental | 1986 |
Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide.
Topics: Acrolein; Aldehyde Dehydrogenase; Biotransformation; Buthionine Sulfoximine; Cell Line; Cell Survival; Cyclophosphamide; DNA Damage; Glutathione; Humans; Leukemia, Myeloid; Liver; Methionine Sulfoximine; Phosphoramide Mustards | 1986 |
Intracellular glutathione as a determinant of responsiveness to antitumor drugs.
Topics: Antibiotics, Antineoplastic; Buthionine Sulfoximine; Cell Line; Chelating Agents; Copper; Daunorubicin; Doxorubicin; Glutathione; Methionine Sulfoximine; Naphthacenes | 1986 |
Effect of glutathione depletion by L-buthionine sulfoximine on the cytotoxicity of cyclophosphamide in single and fractionated doses to EMT6/SF mouse tumors and bone marrow.
Topics: Animals; Bone Marrow; Buthionine Sulfoximine; Cell Survival; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Methionine Sulfoximine; Mice; Neoplasms, Experimental | 1987 |
Reduction of intracellular glutathione content and radiosensitivity.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Repair; Glutathione; HeLa Cells; Humans; In Vitro Techniques; Maleates; Methionine Sulfoximine; Radiation Tolerance | 1986 |
Relationship between cellular glutathione and hyperthermic toxicity in mammary carcinoma in mice.
Topics: Animals; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cysteine; Female; Glutathione; Hyperthermia, Induced; Male; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Sulfhydryl Compounds | 1986 |
The influence of oxygen on the induction of radiation damage in DNA in mammalian cells after sensitization by intracellular glutathione depletion.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; DNA; Glutathione; Humans; Maleates; Methionine Sulfoximine; Oxygen; Radiation-Sensitizing Agents | 1986 |
Manipulation of glutathione contents fails to alter dopaminergic nigrostriatal neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain Stem; Buthionine Sulfoximine; Butylated Hydroxyanisole; Corpus Striatum; Dopamine; Glutathione; Glutathione Transferase; Liver; Maleates; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Pyridines; Substantia Nigra | 1986 |
Effects of fractionated X-irradiation on subsequent response to acute X-irradiation in two human tumour cell lines in vitro.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Glutathione; Humans; Methionine Sulfoximine; Oxidation-Reduction; X-Rays | 1987 |
Rapid-mixing studies of radiosensitivity with thiol-depleted mammalian cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; Ethylmaleimide; Maleates; Mercaptoethanol; Methionine Sulfoximine; Oxygen; Radiation Tolerance; Radiation-Protective Agents; Sulfhydryl Compounds | 1987 |
Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Diquat; Glutathione; In Vitro Techniques; Lipid Peroxides; Liver; Methionine; Methionine Sulfoximine; NADP; Oxidation-Reduction; Oxygen; Pyridinium Compounds; Rats; Rats, Inbred Strains; Subcellular Fractions; Vitamin E | 1986 |
Effect of cellular glutathione depletion on cadmium-induced cytotoxicity in human lung carcinoma cells.
Topics: Buthionine Sulfoximine; Cadmium; Cell Survival; Glutathione; Humans; Lung Neoplasms; Maleates; Methionine Sulfoximine; Tumor Cells, Cultured | 1987 |
The metabolism of acetonitrile to cyanide by isolated rat hepatocytes.
Topics: Acetone; Acetonitriles; Animals; Buthionine Sulfoximine; Cyanides; Cytochrome P-450 Enzyme System; Female; Hemoglobins; In Vitro Techniques; Kinetics; Liver; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1987 |
Determination of L-buthionine-(S,R)-sulfoximine in plasma by high-performance liquid chromatography with o-phthalaldehyde derivatization and fluorometric detection.
Topics: Buthionine Sulfoximine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Methionine Sulfoximine; o-Phthalaldehyde; Spectrometry, Fluorescence | 1987 |
Effect of glutathione modulation using buthionine sulfoximine on DNA methylation by dimethylnitrosamine in the rat.
Topics: Animals; Buthionine Sulfoximine; Dimethylnitrosamine; DNA; Glutathione; Kidney; Liver; Male; Methionine Sulfoximine; Methylation; Rats; Rats, Inbred Strains | 1987 |
Lack of induction of nuclear aberrations by captan in mouse duodenum.
Topics: Animals; Buthionine Sulfoximine; Captan; Cell Nucleus; Dimethylhydrazines; DNA Damage; Duodenum; Male; Methionine Sulfoximine; Mice; Phthalimides | 1987 |
Reduced thiol content in L1210 cells treated with BSO increases DNA crosslinking by melphalan.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cross-Linking Reagents; DNA Damage; DNA, Neoplasm; Glutathione; Leukemia L1210; Melphalan; Methionine Sulfoximine; Mice; Sulfhydryl Compounds | 1987 |
Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on human and murine tumor cells.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Female; Glutathione; Humans; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms; Sulfhydryl Compounds | 1986 |
The effect of glutathione depletion by diamide, diethyl maleate or buthione sulfoximine on the surface structure of mouse L-cells.
Topics: Animals; Azo Compounds; Buthionine Sulfoximine; Cell Membrane; Diamide; Glutathione; L Cells; Maleates; Methionine Sulfoximine; Mice; Microscopy, Electron; Microscopy, Electron, Scanning | 1987 |
Enhancement of the embryotoxicity of acrolein, but not phosphoramide mustard, by glutathione depletion in rat embryos in vitro.
Topics: Abnormalities, Drug-Induced; Acrolein; Aldehydes; Animals; Buthionine Sulfoximine; Drug Synergism; Embryo, Mammalian; Female; Fetal Death; Glutathione; Methionine Sulfoximine; Phosphoramide Mustards; Pregnancy; Rats; Rats, Inbred Strains | 1987 |
A role of vitamin E in protection against cell injury. Maintenance of intracellular glutathione precursors and biosynthesis.
Topics: Animals; Buthionine Sulfoximine; Calcium; Glutathione; Lipid Peroxides; Liver; Male; Methionine Sulfoximine; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; Vitamin E | 1987 |
Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation.
Topics: Acridine Orange; Animals; Buthionine Sulfoximine; Cell Cycle; Concanavalin A; Flow Cytometry; Glutathione; Lymphocyte Activation; Lymphocytes; Mercaptoethanol; Methionine Sulfoximine; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thymidine | 1987 |
Modification of antitumor disulfide cytotoxicity by glutathione depletion in murine cells.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cells, Cultured; Disulfides; Glutathione; Mercaptopurine; Methionine Sulfoximine; Mice; Oxygen; Sulfhydryl Compounds; Thioguanine | 1987 |
Effects of buthionine sulfoximine and cysteine on the hepatotoxicity of butylated hydroxytoluene in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Buthionine Sulfoximine; Butylated Hydroxytoluene; Chemical and Drug Induced Liver Injury; Cysteine; Drug Interactions; Glutathione; Lethal Dose 50; Liver Diseases; Male; Methionine Sulfoximine; Rats; Rats, Inbred F344 | 1987 |
Effects of glutathione depletion on the cytotoxicity of agents toward a human colonic tumour cell line.
Topics: Antimetabolites; Antineoplastic Agents, Phytogenic; Buthionine Sulfoximine; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Naphthols; Naphthoquinones; Sesquiterpenes; Sesquiterpenes, Guaiane; Vitamin K | 1987 |
Depletion of tumour versus normal tissue glutathione by buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glutathione; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Sarcoma, Experimental; Time Factors; Tissue Distribution | 1987 |
Compartmentalised depletion of glutathione in cells treated with buthionine sulphoximine.
Topics: Animals; Buthionine Sulfoximine; Cell Nucleus; Cells, Cultured; Cricetinae; Cricetulus; Glutathione; Methionine Sulfoximine | 1987 |
Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Cysteine; Drug Therapy; Glutathione; Liver; Methionine Sulfoximine; Mice; Prodrugs; Rats; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1987 |
Flow cytometry analysis of DNA damage and the evaluation of cytotoxicity of alkylating agents.
Topics: Alkylating Agents; Antibodies, Monoclonal; Buthionine Sulfoximine; Cell Survival; DNA; DNA Damage; Dose-Response Relationship, Drug; Flow Cytometry; Hot Temperature; Humans; Methionine Sulfoximine | 1987 |
Mercaptoethanol protects glutathione depleted cells.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cystine; Glutathione; Leukemia L1210; Mercaptoethanol; Methionine Sulfoximine; Mice; Sulfhydryl Compounds | 1987 |
Glutathione protection against irreversible binding of diethylstilbestrol in the hamster renal cortex.
Topics: Animals; Buthionine Sulfoximine; Cricetinae; Diethylstilbestrol; Glutathione; In Vitro Techniques; Kidney Cortex; Male; Maleates; Mesocricetus; Methionine Sulfoximine | 1987 |
The effect of depletion of nonprotein sulfhydryls by diethyl maleate plus buthionine sulfoximine on renal uptake of mercury in the rat.
Topics: Animals; Buthionine Sulfoximine; Drug Interactions; In Vitro Techniques; Kidney; Kidney Cortex; Lactates; Lactic Acid; Liver; Male; Maleates; Mercury; Methionine Sulfoximine; p-Aminohippuric Acid; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Tetraethylammonium; Tetraethylammonium Compounds | 1986 |
Multiple effects of presumed glutathione depletors on rabbit proximal tubules.
Topics: Animals; Buthionine Sulfoximine; Culture Techniques; Cyclohexanones; Female; Glutathione; Ketones; Kidney Concentrating Ability; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Maleates; Methionine Sulfoximine; Oxygen Consumption; Rabbits | 1986 |
Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice.
Topics: Age Factors; Animals; Buthionine Sulfoximine; Cataract; Disease Models, Animal; Glutathione; Humans; Kidney; Lens, Crystalline; Liver; Male; Methionine Sulfoximine; Mice; Testis | 1986 |
Relationship of glutathione depletion and inhibition of glutathione-S-transferase activity to the antimitotic properties of estramustine.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Drug Synergism; Estramustine; Glutathione; Glutathione Transferase; Humans; Male; Metaphase; Methionine Sulfoximine; Mitosis; Mitotic Index; Nitrogen Mustard Compounds; Prostatic Neoplasms; Tumor Stem Cell Assay | 1986 |
Enhancement of intracellular glutathione promotes lymphocyte activation by mitogen.
Topics: Animals; Buthionine Sulfoximine; Glutathione; Lymphocyte Activation; Lymphocytes; Mercaptoethanol; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mitogens; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1986 |
Oxygen concentration and the OER for acutely or chronically thiol deficient cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Oxygen; Radiation Tolerance | 1986 |
The effect of L-buthionine sulfoximine on the aerobic radiation response of A549 human lung carcinoma cells.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1986 |
Specificity of endogenous glutathione in determining the oxygen enhancement of cellular radiosensitivity.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Oxygen; Radiation Tolerance | 1986 |
Combined radiation-protective and radiation-sensitizing agents. III: Radiosensitization by misonidazole as a function of concentrations of endogenous glutathione or exogenous thiols.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; Cysteamine; Glutathione; In Vitro Techniques; Methionine Sulfoximine; Misonidazole; Radiation-Sensitizing Agents | 1986 |
Toxic effects of extended glutathione depletion by buthionine sulfoximine on murine mammary carcinoma cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Glutathione; In Vitro Techniques; Methionine Sulfoximine; Mice; Time Factors | 1986 |
Effects of glutathione depletion by buthionine sulfoximine on the sensitivity of EMT6/SF cells to chemotherapy agents or X radiation.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Glutathione; In Vitro Techniques; Methionine Sulfoximine; Mice; Oxygen; Radiation Tolerance | 1986 |
Glutathione levels and cytotoxicity of a thiol activated alkylating agent in human and mouse cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Methylnitronitrosoguanidine; Mice; Mitomycins | 1986 |
In vivo modulation of glutathione by buthionine sulfoximine: effect on marrow response to melphalan.
Topics: Animals; Bone Marrow; Buthionine Sulfoximine; Drug Synergism; Female; Glutathione; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1986 |
Inhibition of the protective effect of cyclophosphamide by pre-treatment with buthionine sulfoximine.
Topics: Animals; Bone Marrow; Buthionine Sulfoximine; Cyclophosphamide; Glutathione; Glutathione Transferase; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1986 |
Glutathione depletion by DL-buthionine-SR-sulfoximine (BSO) potentiates X-ray-induced chromosome lesions after liquid holding recovery.
Topics: Animals; Buthionine Sulfoximine; Carcinoma, Ehrlich Tumor; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Cricetulus; DNA Repair; Dose-Response Relationship, Drug; Female; Glutathione; Methionine Sulfoximine; Ovary | 1986 |
Radiosensitizing effect of misonidazole in combination with an inhibitor of glutathione synthesis in murine tumors.
Topics: Animals; Buthionine Sulfoximine; Combined Modality Therapy; Drug Therapy, Combination; Glutathione; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms, Experimental; Radiation-Sensitizing Agents | 1986 |
Slow biliary elimination of methyl mercury in the marine elasmobranchs, Raja erinacea and Squalus acanthias.
Topics: Animals; Bile; Buthionine Sulfoximine; Dogfish; Electric Fish; Glutathione; Methionine Sulfoximine; Methylmercury Compounds; Sharks; Skates, Fish; Sulfobromophthalein; Time Factors | 1986 |
Inhibition of the acute toxicity of methyl chloride in male B6C3F1 mice by glutathione depletion.
Topics: Animals; Atmosphere Exposure Chambers; Brain; Buthionine Sulfoximine; Female; Glutathione; Inactivation, Metabolic; Kidney; Kidney Function Tests; Liver; Male; Methionine Sulfoximine; Methyl Chloride; Mice; Organ Size | 1986 |
Effect of diethylmaleate and other glutathione depletors on protein synthesis.
Topics: Animals; Body Temperature; Brain; Buthionine Sulfoximine; Glutathione; Ketones; Liver; Male; Maleates; Methionine Sulfoximine; Mice; Protein Biosynthesis | 1986 |
Accumulation of non-protein metal-binding polypeptides (gamma-glutamyl-cysteinyl)n-glycine in selected cadmium-resistant tomato cells.
Topics: Amino Acid Sequence; Buthionine Sulfoximine; Cadmium; Cadmium Chloride; Drug Resistance; Glutathione; Mass Spectrometry; Methionine Sulfoximine; Phenotype; Plants | 1986 |
Elevation of intracellular glutathione content associated with mitogenic stimulation of quiescent fibroblasts.
Topics: Animals; Blood; Buthionine Sulfoximine; Cell Division; Cell Line; Cyclohexanones; DNA Replication; Fibroblasts; Glutathione; Methionine Sulfoximine; Mice; Mitogens; Time Factors | 1986 |
Quantitative analysis of cellular glutathione by flow cytometry utilizing monochlorobimane: some applications to radiation and drug resistance in vitro and in vivo.
Topics: Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Buthionine Sulfoximine; Cell Line; Cells, Cultured; Drug Resistance; Flow Cytometry; Fluorescent Dyes; Gene Amplification; Glutathione; Methionine Sulfoximine; Mice; Misonidazole; Oxygen | 1986 |
Isolation and characterization of a Chinese hamster ovary cell line resistant to bifunctional nitrogen mustards.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cross-Linking Reagents; Drug Resistance; Glutathione; Glutathione Transferase; Karyotyping; Methionine Sulfoximine; Nitrogen Mustard Compounds; Protein Biosynthesis | 1986 |
Differential glutathione depletion by L-buthionine-S,R-sulfoximine in rat embryo versus visceral yolk sac in vivo and in vitro.
Topics: Animals; Buthionine Sulfoximine; Culture Techniques; Embryo, Mammalian; Female; Glutathione; Maternal-Fetal Exchange; Methionine Sulfoximine; Pregnancy; Rats; Rats, Inbred Strains; Time Factors; Yolk Sac | 1986 |
Protection against paraquat-induced injury by exogenous GSH in pulmonary alveolar type II cells.
Topics: Animals; Biological Transport; Buthionine Sulfoximine; Dipeptides; Glutathione; Isoxazoles; Kinetics; Lung Diseases; Male; Methionine Sulfoximine; Paraquat; Probenecid; Pulmonary Alveoli; Rats; Rats, Inbred Strains; Sodium | 1986 |
Role of hepatic glutathione and glucocorticoids in the regulation of hepatic cholesterol 7 alpha-hydroxylase.
Topics: Adrenalectomy; Animals; Buthionine Sulfoximine; Cholesterol 7-alpha-Hydroxylase; Food; Glucocorticoids; Glutathione; Liver; Male; Methionine Sulfoximine; Microsomes, Liver; Rats; Rats, Inbred Strains; Steroid Hydroxylases | 1986 |
The role of glutathione in the aerobic radioresponse. I. Sensitization and recovery in the absence of intracellular glutathione.
Topics: Aerobiosis; Buthionine Sulfoximine; Cell Line; Cell Membrane; Culture Media; Glutathione; Methionine Sulfoximine; Radiation Tolerance | 1986 |
Hepatotoxicity of butylated hydroxytoluene and its analogs in mice depleted of hepatic glutathione.
Topics: Alanine Transaminase; Animals; Buthionine Sulfoximine; Butylated Hydroxytoluene; Calcium; Chemical and Drug Induced Liver Injury; Disulfides; Glutathione; Liver; Male; Methionine Sulfoximine; Mice | 1987 |
Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione.
Topics: Animals; Buthionine Sulfoximine; Colony-Forming Units Assay; Drug Resistance; Drug Synergism; Female; Glutathione; Histocytochemistry; Humans; Melphalan; Methionine Sulfoximine; Mice; Mice, Nude; Ovarian Neoplasms | 1987 |
Combined effect of buthionine sulfoximine and cyclophosphamide upon murine tumours and bone marrow.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Buthionine Sulfoximine; Cell Survival; Colony-Forming Units Assay; Cyclophosphamide; Cysteine; Glutathione; Lung Neoplasms; Male; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1986 |
Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cisplatin; DNA, Neoplasm; Drug Resistance; Glutathione; Leukemia L1210; Methionine Sulfoximine | 1987 |
The effect of buthionine sulphoximine, cimetidine and phenobarbitone on the disposition of amsacrine in the rabbit.
Topics: Amsacrine; Animals; Buthionine Sulfoximine; Cimetidine; Erythrocytes; Glutathione; Kinetics; Liver; Methionine Sulfoximine; Mixed Function Oxygenases; Phenobarbital; Rabbits | 1986 |
Modulation of drug resistance in human ovarian cancer: experimental results and clinical applications.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Doxorubicin; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Methionine Sulfoximine; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Transplantation, Heterologous; Verapamil | 1986 |
Glutathione levels in cultured heart cells. Influence of buthionine sulfoximine, an inhibitor of glutathione synthesis.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cells, Cultured; Glutathione; Glutathione Disulfide; Heart; Kinetics; Methionine Sulfoximine; Myocardium; Rats; Rats, Inbred Strains | 1987 |
Metabolic activation of the tricyclic antidepressant amineptine--II. Protective role of glutathione against in vitro and in vivo covalent binding.
Topics: Animals; Antidepressive Agents, Tricyclic; Biotransformation; Buthionine Sulfoximine; Cricetinae; Dibenzocycloheptenes; Glutathione; Ketones; Kinetics; Male; Mesocricetus; Methionine Sulfoximine; Microsomes, Liver; NADP; Phenobarbital; Piperonyl Butoxide | 1987 |
Chemosensitization of L-phenylalanine mustard by the thiol-modulating agent buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Drug Synergism; Glutathione; Leukemia L1210; Male; Melphalan; Methionine Sulfoximine; Mice; Thymidine | 1987 |
Lack of enhanced myelotoxicity with buthionine sulfoximine and sulfhydryl-dependent anticancer agents in mice.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Buthionine Sulfoximine; Cell Survival; Glutathione; In Vitro Techniques; Kidney; Lethal Dose 50; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred DBA; Spleen; Sulfhydryl Compounds | 1987 |
Relationship between thiol depletion and chemosensitization in a transplantable murine bladder tumor.
Topics: Animals; Buthionine Sulfoximine; Carcinoma, Transitional Cell; Cyclophosphamide; Drug Combinations; Drug Resistance; Female; Glutathione; Liver; Maleates; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Urinary Bladder Neoplasms | 1985 |
Origin and turnover of mitochondrial glutathione.
Topics: Animals; Buthionine Sulfoximine; Cystine; Glutamates; Glutathione; Kinetics; Liver; Methionine Sulfoximine; Mitochondria, Liver; Rats; Sulfur Radioisotopes | 1985 |
Combined effect of misonidazole and glutathione depletion by buthionine sulphoximine on cellular radiation response.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; Cricetulus; DNA, Single-Stranded; Dose-Response Relationship, Drug; Fibroblasts; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Radiation Tolerance | 1985 |
Glutathione requirement for the rejoining of radiation-induced DNA breaks in misonidazole-treated cells.
Topics: Buthionine Sulfoximine; DNA; DNA Repair; DNA, Single-Stranded; Fibroblasts; Glutathione; Humans; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1985 |
On the importance of the level of glutathione and the activity of the pentose phosphate pathway in heat sensitivity and thermotolerance.
Topics: Animals; Buthionine Sulfoximine; Carcinoma, Ehrlich Tumor; Cell Line; Cell Survival; Fibroblasts; Glutathione; Hot Temperature; Maleates; Methionine Sulfoximine; Mice; Pentose Phosphate Pathway; Sulfhydryl Compounds | 1985 |
Participation of cellular thiol/disulphide groups in the uptake, degradation and bioactivity of insulin in primary cultures of rat hepatocytes.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Disulfides; Dithiothreitol; Glutathione; Insulin; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Sulfhydryl Reagents | 1985 |
Decreased hepatic glutathione levels in septic shock. Predisposition of hepatocytes to oxidative stress: an experimental approach.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Escherichia coli Infections; Glutathione; Hydrogen Peroxide; Liver; Liver Function Tests; Methionine Sulfoximine; Multiple Organ Failure; Oxidation-Reduction; Protein Biosynthesis; Sheep; Shock, Septic | 1985 |
Role of glutathione turnover in drug sulfation: differential effects of diethylmaleate and buthionine sulfoximine on the pharmacokinetics of acetaminophen in the rat.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Glutathione; Kidney; Kinetics; Male; Maleates; Metabolic Clearance Rate; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Sulfates | 1986 |
Role of glutathione depletion in the mechanism of action of N-methylformamide and N,N-dimethylformamide in a cultured human colon carcinoma cell line.
Topics: Buthionine Sulfoximine; Cell Cycle; Cell Line; Cisplatin; Colonic Neoplasms; Cysteine; Dimethylformamide; Dose-Response Relationship, Drug; Formamides; Glutathione; Humans; Methionine Sulfoximine; Solvents | 1986 |
A new method to study glutathione adduct formation in periportal and pericentral regions of the liver lobule by micro-reflectance spectrophotometry.
Topics: Animals; Buthionine Sulfoximine; Dinitrochlorobenzene; Female; Glutathione; In Vitro Techniques; Light; Liver; Methionine Sulfoximine; Nitrobenzenes; Perfusion; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry | 1986 |
Influence of buthionine sulfoximine and misonidazole on glutathione level and radiosensitivity of human tumor xenografts.
Topics: Adenocarcinoma; Animals; Buthionine Sulfoximine; Cell Line; Colonic Neoplasms; Female; Glutathione; Humans; Melanoma; Methionine Sulfoximine; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Radiation Tolerance; Transplantation, Heterologous | 1986 |
Evidence that glutathione participates in the induction of a stress protein.
Topics: Buthionine Sulfoximine; Dinitrochlorobenzene; Ethylmaleimide; Glutathione; Heat-Shock Proteins; Maleates; Methionine Sulfoximine; Molecular Weight | 1986 |
Glutathione depletion: does it influence radiosensitization by misonidazole?
Topics: Buthionine Sulfoximine; Drug Interactions; Glutathione; Methionine Sulfoximine; Misonidazole | 1986 |
Cellular glutathione, thermal sensitivity, and thermotolerance in Chinese hamster fibroblasts and their heat-resistant variants.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Fibroblasts; Glutathione; Hot Temperature; Hyperthermia, Induced; Methionine Sulfoximine; Neoplasms; Time Factors | 1986 |
Kinetics of glutathione efflux from isolated rat hepatocytes.
Topics: Animals; Buthionine Sulfoximine; Glutathione; Kinetics; Liver; Male; Maleates; Methionine Sulfoximine; Osmolar Concentration; Rats; Rats, Inbred Strains; Temperature | 1986 |
Decreased intracellular glutathione concentration and increased hyperthermic cytotoxicity in an acid environment.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; Cricetulus; Female; Glutathione; Hydrogen-Ion Concentration; Hyperthermia, Induced; Methionine Sulfoximine; Ovary | 1985 |
Buthionine sulfoximine inhibition of cystine uptake and glutathione biosynthesis in human lung carcinoma cells.
Topics: Buthionine Sulfoximine; Cell Line; Cysteine; Cystine; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Sulfur Radioisotopes | 1985 |
Enhancement of intracellular glutathione protects endothelial cells against oxidant damage.
Topics: Animals; Buthionine Sulfoximine; Cattle; Endothelium; Glucose Oxidase; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1985 |
Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Drug Resistance; Female; Glutathione; Humans; Methionine Sulfoximine; Ovarian Neoplasms | 1985 |
Adaptive cellular response to hyperthermia: 31P-NMR studies.
Topics: Adenosine Triphosphate; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Fibroblasts; Glutathione; Heat-Shock Proteins; Hot Temperature; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Phosphates | 1985 |
Effects of glutathione depletion using buthionine sulphoximine on the cytotoxicity of nitroaromatic compounds in mammalian cells in vitro.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Glutathione; Methionine Sulfoximine; Misonidazole; Nitrofurantoin; Nitroimidazoles | 1985 |
Biliary excretion and enterohepatic circulation of 1-nitropyrene metabolites in Fischer-344 rats.
Topics: Animals; Anti-Bacterial Agents; Bile; Buthionine Sulfoximine; Carbon Radioisotopes; Enterohepatic Circulation; Male; Methionine Sulfoximine; Pyrenes; Rats; Rats, Inbred F344; Tritium | 1985 |
Effects of buthionine sulfoximine on the nephrotoxicity of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU).
Topics: Animals; Buthionine Sulfoximine; Glutathione; Glutathione Reductase; Kidney; Liver; Male; Methionine Sulfoximine; Nitrosourea Compounds; Rats; Rats, Inbred F344; Semustine | 1985 |
Effects of glutathione depletion on gluconeogenesis in isolated hepatocytes.
Topics: Adenosine Triphosphate; Animals; Buthionine Sulfoximine; Cell Survival; Gluconeogenesis; Glutathione; Glycerophosphates; Ketones; Liver; Malates; Maleates; Malondialdehyde; Methionine Sulfoximine; Rats; Urea | 1985 |
The role of glutathione in lymphocyte activation. I. Comparison of inhibitory effects of buthionine sulfoximine and 2-cyclohexene-1-one by nuclear size transformation.
Topics: Buthionine Sulfoximine; Cell Nucleus; Cell Survival; Cyclohexanes; Cyclohexanones; Glutathione; Humans; Immunosuppressive Agents; Intracellular Fluid; Lymphocyte Activation; Lymphocytes; Methionine Sulfoximine; Time Factors | 1985 |
Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Cisplatin; Doxorubicin; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms | 1985 |
Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion.
Topics: Alkylating Agents; Buthionine Sulfoximine; Carcinoma; Cell Line; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Methionine Sulfoximine; Organoplatinum Compounds; Ovarian Neoplasms | 1985 |
Effects of glutathione depletion by buthionine sulfoximine on radiosensitization by oxygen and misonidazole in vitro.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Drug Synergism; Glutathione; Mathematics; Methionine Sulfoximine; Misonidazole; Oxygen; Radiation-Sensitizing Agents | 1985 |
Hepatocytes in primary culture become susceptible to paracetamol injury after depletion of glutathione using DL-buthionine-SR-sulphoximine (BSO).
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Cells, Cultured; Glutathione; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1985 |
Cell surface thiols, but not intracellular glutathione, are essential for cytolysis by a cloned murine natural killer cell line.
Topics: Animals; Buthionine Sulfoximine; Cell Membrane; Clone Cells; Cytotoxicity, Immunologic; Glutathione; Killer Cells, Natural; Membrane Proteins; Methionine Sulfoximine; Mice; Neoplasms, Experimental; Quaternary Ammonium Compounds; Sulfhydryl Compounds | 1985 |
The effect of glutathione on development in wild carrot suspension cultures.
Topics: Buthionine Sulfoximine; Cell Division; Glutathione; Glutathione Disulfide; Methionine Sulfoximine; Plant Development; Plants | 1985 |
Glutathione levels in human platelets display a circadian rhythm in vitro.
Topics: Adult; Blood Platelets; Buthionine Sulfoximine; Circadian Rhythm; Darkness; Erythrocytes; Glutathione; Glutathione Disulfide; Humans; In Vitro Techniques; Light; Methionine Sulfoximine; Oxidation-Reduction; Work Schedule Tolerance | 1985 |
Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Free Radicals; Glutathione; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1985 |
Roles of thiols in cellular radiosensitivity.
Topics: Amifostine; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Methionine Sulfoximine; Misonidazole; Oxygen; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1984 |
Glutathione turnover in human erythrocytes. Inhibition by buthionine sulfoximine and incorporation of glycine by exchange.
Topics: Buthionine Sulfoximine; Cysteine; Erythrocytes; Glutamates; Glutamic Acid; Glutathione; Glycine; Humans; Kinetics; Methionine Sulfoximine | 1981 |
Depletion of glutathione selectively inhibits synthesis of leukotriene C by macrophages.
Topics: Animals; Arachidonic Acids; Buthionine Sulfoximine; Female; Glutamate-Cysteine Ligase; Glutathione; Macrophages; Methionine Sulfoximine; Mice; Peptide Synthases; SRS-A | 1981 |
Depletion of glutathione by inhibition of biosynthesis.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Chemical Phenomena; Chemistry; Glutamate-Cysteine Ligase; Glutathione; Kidney; Liver; Methionine Sulfoximine; Muscles; Pancreas | 1981 |
Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.
Topics: Animals; Buthionine Sulfoximine; Glutamate-Cysteine Ligase; Glutathione; Kidney; Kinetics; Methionine Sulfoximine; Peptide Synthases; Structure-Activity Relationship; Swine | 1982 |
Radioprotection of human lymphoid cells by exogenously supplied glutathione is mediated by gamma-glutamyl transpeptidase.
Topics: Acyltransferases; Buthionine Sulfoximine; Cell Line; Glutathione; Humans; Kinetics; Methionine Sulfoximine; Multiple Myeloma; Radiation-Protective Agents; T-Lymphocytes; Transglutaminases | 1983 |
Nigrostriatal dopaminergic neurons remain undamaged in rats given high doses of L-DOPA and carbidopa chronically.
Topics: Animals; Buthionine Sulfoximine; Carbidopa; Corpus Striatum; Dopamine; Female; Glutathione; Levodopa; Methionine Sulfoximine; Neurons; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine 3-Monooxygenase | 1984 |
The effects of buthionine sulphoximine (BSO) on glutathione depletion and xenobiotic biotransformation.
Topics: Acetaminophen; Animals; Biotransformation; Buthionine Sulfoximine; Glutamate-Cysteine Ligase; Glutathione; In Vitro Techniques; Male; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1984 |
Glutathione biosynthesis in the isolated perfused rat lung: utilization of extracellular glutathione.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutamates; Glutathione; In Vitro Techniques; Lung; Male; Methionine Sulfoximine; Perfusion; Rats; Rats, Inbred Strains | 1984 |
Flow cytometry techniques for studying cellular thiols.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Cricetinae; Cricetulus; Flow Cytometry; Fumarates; Glutathione; Lung; Maleates; Methionine Sulfoximine; Oxygen; Radiation Tolerance; Staining and Labeling; Sulfhydryl Compounds; Sulfhydryl Reagents | 1983 |
Alteration of bleomycin cytotoxicity by glutathione depletion or elevation.
Topics: Animals; Bleomycin; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors | 1984 |
Radiosensitizers: a conference preview.
Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Depletion of glutathione in vivo as a method of improving the therapeutic ratio of misonidazole and SR 2508.
Topics: Animals; Buthionine Sulfoximine; Combined Modality Therapy; Etanidazole; Glutathione; Maleates; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Glutathione depletion enhances the lifetime of oxygen-reactive radicals in mammalian cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Glutathione; Methionine Sulfoximine; Oxygen; Radiation Tolerance; Time Factors | 1984 |
Increased glutathione in cultured hepatocytes associated with induction of cytochrome P-450. Lack of effect of glutathione depletion on induction of cytochrome P-450 and delta-aminolevulinate synthase.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Buthionine Sulfoximine; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronates; Glutathione; Insulin; Liver; Methionine Sulfoximine; Methylcholanthrene; Phenolsulfonphthalein | 1984 |
Glutathione-dependent yield and repair of single-strand DNA breaks in irradiated cells.
Topics: Buthionine Sulfoximine; Cell Survival; Cells, Cultured; DNA Repair; DNA, Single-Stranded; Egtazic Acid; Glutathione; Humans; Male; Methionine Sulfoximine; Misonidazole; Oxygen | 1984 |
Effect of glutathione levels, sulfate levels, and metabolic inhibitors on covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-acetylaminofluorene to cell macromolecules in primary monolayer cultures of adult rat hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Buthionine Sulfoximine; Cells, Cultured; Glutathione; Liver; Methionine Sulfoximine; Mutagens; Nucleic Acids; Pentachlorophenol; Polychlorinated Biphenyls; Proteins; Quinolines; Rats; Rats, Inbred Strains; Sulfuric Acids | 1984 |
Factors involved in depletion of glutathione from A549 human lung carcinoma cells: implications for radiotherapy.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Glutathione; Humans; Lung Neoplasms; Maleates; Methionine Sulfoximine; Radiation-Sensitizing Agents; Time Factors | 1984 |
Depletion of intracellular GSH and NPSH by buthionine sulfoximine and diethyl maleate: factors that influence enhancement of aerobic radiation response.
Topics: Aerobiosis; Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Glutathione; Humans; Lung Neoplasms; Maleates; Methionine Sulfoximine; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Time Factors | 1984 |
Effects of D,L-buthionine-S,R-sulfoximine on cellular thiol levels and the oxygen effect in Chinese hamster V79 cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Glutathione; Methionine Sulfoximine; Oxygen; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1984 |
Radiation response of Chinese hamster cells after elevation of intracellular glutathione levels.
Topics: Aerobiosis; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cobalt; Cricetinae; Cricetulus; Cysteamine; Dose-Response Relationship, Radiation; Glutathione; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Radiation-Sensitizing Agents; Thiazoles; Thiazolidines | 1984 |
Effects of BSO and DEM on thiol-level and radiosensitivity in HeLa cells.
Topics: Buthionine Sulfoximine; Cell Survival; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Radiation; HeLa Cells; Humans; Maleates; Methionine Sulfoximine; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1984 |
Effects of cellular non-protein sulfhydryl depletion in radiation induced oncogenic transformation and genotoxicity in mouse C3H 10T1/2 cells.
Topics: Aerobiosis; Animals; Buthionine Sulfoximine; Cell Line; Cell Transformation, Neoplastic; Cesium Radioisotopes; Crossing Over, Genetic; Dose-Response Relationship, Drug; Gamma Rays; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Mitosis; Sister Chromatid Exchange; Sulfhydryl Compounds | 1984 |
Glutathione depletion in tissues after administration of buthionine sulphoximine.
Topics: Animals; Buthionine Sulfoximine; Female; Glutathione; Kidney; Liver; Methionine Sulfoximine; Mice; Muscles; Neoplasm Transplantation; Neoplasms, Experimental; Time Factors | 1984 |
Chemosensitization: do thiols matter?
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Synergism; Melphalan; Methionine Sulfoximine; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1984 |
The effect of buthionine sulfoximine, an inhibitor of glutathione synthesis, on hepatic drug metabolism in the male mouse.
Topics: Animals; Biotransformation; Buthionine Sulfoximine; Carbon Tetrachloride Poisoning; Chloroform; Cytochrome P-450 Enzyme System; Glutathione; Glutathione Transferase; Liver; Male; Methionine Sulfoximine; Mixed Function Oxygenases; Oxygenases; Rats; Rats, Inbred F344; Sulfhydryl Compounds | 1984 |
L1210(A) mouse lymphoma cells depleted of glutathione with L-buthionine-S-R-sulfoximine proliferate in tissue culture.
Topics: Animals; Buthionine Sulfoximine; Cell Compartmentation; Cell Division; Chromatography, High Pressure Liquid; Culture Techniques; Glutathione; Leukemia L1210; Methionine Sulfoximine; Mice; Time Factors | 1984 |
Subcellular glutathione contents in isolated hepatocytes treated with L-buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cytosol; Dithionitrobenzoic Acid; Glutathione; Glutathione Reductase; Kinetics; Liver; Male; Methionine Sulfoximine; Mitochondria, Liver; Rats; Rats, Inbred Strains | 1984 |
Mechanism of action of paracetamol protective agents in mice in vivo.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Buthionine Sulfoximine; Cysteamine; Cysteine; Glutathione; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1984 |
Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Cystine; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Kinetics; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms | 1984 |
[Increased effect of hypoxic cell radiation sensitizers in combination with BSO, a substance depleting the intracellular radioprotective thiols].
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; DNA; Drug Synergism; Methionine Sulfoximine; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1984 |
Enhancement of misonidazole radiosensitization by buthionine sulphoximine.
Topics: Animals; Buthionine Sulfoximine; Combined Modality Therapy; Dose-Response Relationship, Radiation; Drug Synergism; Glutathione; Methionine Sulfoximine; Mice; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Skin | 1984 |
Modification of butylated hydroxytoluene-induced pulmonary toxicity in mice by diethyl maleate, buthionine sulfoximine, and cysteine.
Topics: Animals; Body Weight; Buthionine Sulfoximine; Butylated Hydroxytoluene; Cysteine; Drug Synergism; Glutathione; Liver; Lung; Male; Maleates; Methionine Sulfoximine; Mice; Organ Size | 1984 |
Glutathione depletion, radiosensitization, and misonidazole potentiation in hypoxic Chinese hamster ovary cells by buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Drug Synergism; Female; Glutathione; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Ovary; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1984 |
Transport of glutathione, as gamma-glutamylcysteinylglycyl ester, into liver and kidney.
Topics: Animals; Biological Transport; Buthionine Sulfoximine; Glutathione; Kidney; Kinetics; Liver; Methionine Sulfoximine; Mice; Structure-Activity Relationship | 1983 |
Enhancement of misonidazole radiosensitization by an inhibitor of glutathione biosynthesis.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Glutathione; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance | 1983 |
Thiols, thiol depletion, and thermosensitivity.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cricetinae; Cysteine; Glutathione; Heat-Shock Proteins; Hot Temperature; Maleates; Methionine Sulfoximine; Oxidation-Reduction; Oxygen Consumption; Protein Biosynthesis; Sulfhydryl Compounds; Time Factors | 1983 |
Selective glutathione depletion on function and structure of the isolated perfused rat kidney.
Topics: Amino Acids; Animals; Buthionine Sulfoximine; Cyclohexanones; Glomerular Filtration Rate; Glucose; Glutathione; Kidney; Kidney Concentrating Ability; Loop of Henle; Male; Maleates; Methionine Sulfoximine; Natriuresis; Perfusion; Rats; Rats, Inbred Strains | 1983 |
Cellular glutathione depletion by diethyl maleate or buthionine sulfoximine: no effect of glutathione depletion on the oxygen enhancement ratio.
Topics: Animals; Buthionine Sulfoximine; Carcinoma; Cell Line; Cells, Cultured; Cricetinae; Dose-Response Relationship, Radiation; Glutathione; Humans; Hypoxia; Lung; Lung Neoplasms; Maleates; Methionine Sulfoximine; Oxygen Consumption; Radiation-Sensitizing Agents; Time Factors | 1983 |
The role of thiols in cellular response to radiation and drugs.
Topics: Animals; Azo Compounds; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; Cricetinae; Diamide; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Glutathione; Humans; Lung Neoplasms; Maleates; Methionine Sulfoximine; Ovary; Oxygen; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1983 |
Reduction in cellular glutathione by buthionine sulfoximine and sensitization of murine tumor cells resistant to L-phenylalanine mustard.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Drug Resistance; Female; Glutathione; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred DBA; Neoplasms, Experimental | 1984 |
Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide.
Topics: Animals; Blood Vessels; Buthionine Sulfoximine; Carmustine; Cattle; Cells, Cultured; Dinitrochlorobenzene; Endothelium; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Humans; Hydrogen Peroxide; Maleates; Methionine Sulfoximine; Oxidation-Reduction | 1984 |
State of sulfhydryl in selenite cataract.
Topics: Animals; Buthionine Sulfoximine; Cataract; Crystallins; Female; Glutathione; Hexosephosphates; Methionine Sulfoximine; Oxidation-Reduction; Rats; Rats, Inbred Strains; Selenious Acid; Selenium; Sulfhydryl Compounds | 1984 |
The effects of glutathione depletion on thermotolerance and heat stress protein synthesis.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Depression, Chemical; Electrophoresis, Polyacrylamide Gel; Glutathione; Heat-Shock Proteins; Hot Temperature; Methionine Sulfoximine; Time Factors | 1984 |
The role of glutathione turnover in the apparent renal secretion of cystine.
Topics: Amino Acids; Animals; Arginine; Biological Transport; Buthionine Sulfoximine; Cystine; Glutathione; Kidney; Kinetics; Liver; Lysine; Methionine Sulfoximine; Mice | 1981 |
Glutathione depletion sensitizes tumor cells to oxidative cytolysis.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Glutathione; Kinetics; Leukemia P388; Mast-Cell Sarcoma; Methionine Sulfoximine; Mice; Neoplasms, Experimental; Tetradecanoylphorbol Acetate | 1982 |
Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation.
Topics: Biological Transport; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Extracellular Space; Gamma Rays; Glutathione; Humans; Lymphocytes; Methionine Sulfoximine | 1981 |
Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis.
Topics: Animals; Buthionine Sulfoximine; Female; Glutathione; Methionine Sulfoximine; Mice; Trypanosoma brucei brucei; Trypanosomiasis, African | 1981 |
Nucleotide changes in oxidatively stressed lymphocytes.
Topics: Buthionine Sulfoximine; Cell Cycle; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Enzyme Inhibitors; Glutathione; Humans; Lymphocyte Activation; Lymphocytes; Methionine Sulfoximine; Muromonab-CD3; Nucleotides; Oxidative Stress; Thymine Nucleotides; Uridine | 1995 |
Glutathione biosynthesis and its inhibition.
Topics: Animals; Buthionine Sulfoximine; Enzyme Inhibitors; Escherichia coli; Glutamate-Cysteine Ligase; Glutathione; Kidney; Methionine Sulfoximine; Rats; Recombinant Proteins | 1995 |
Non-oxidative loss of glutathione in apoptosis via GSH extrusion.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Buthionine Sulfoximine; Cell Line; Cycloheximide; Etoposide; Glutathione; Humans; Hydrogen Peroxide; Kinetics; L-Lactate Dehydrogenase; Methionine Sulfoximine; Oxidation-Reduction; Oxidative Stress; Puromycin | 1995 |
Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Glutathione; Isomerism; Liver; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley | 1995 |
In vivo selective modulation of tissue glutathione in a rat mammary carcinoma model.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Buthionine Sulfoximine; Drug Synergism; Female; Glutathione; Kidney; Liver; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1995 |
Metal-induced genotoxic adaptation in barley (Hordeum vulgare L.) to maleic hydrazide and methyl mercuric chloride.
Topics: Adaptation, Physiological; Antimutagenic Agents; Buthionine Sulfoximine; Cadmium; Cadmium Compounds; Chromosome Aberrations; DNA Repair; Glutathione; Hordeum; Maleic Hydrazide; Mercury; Metalloproteins; Metals; Methionine Sulfoximine; Methylmercury Compounds; Mitotic Index; Mutagens; Phytochelatins; Plant Proteins; Seeds; Spindle Apparatus; Sulfates; Zinc; Zinc Compounds; Zinc Sulfate | 1994 |
Characterization of quinone reductase, glutathione and glutathione S-transferase in human myeloid cell lines: induction by 1,2-dithiole-3-thione and effects on hydroquinone-induced cytotoxicity.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Buthionine Sulfoximine; Dicumarol; Drug Synergism; Enzyme Induction; Glutathione; Glutathione Transferase; Humans; Hydroquinones; Leukemia, Myeloid; Methionine Sulfoximine; Models, Chemical; NAD(P)H Dehydrogenase (Quinone); Peroxidase; Thiones; Thiophenes; Tumor Cells, Cultured | 1994 |
The effect of L-buthionine-[S,R]-sulfoximine on the pancreas in mice. A model of weakening glutathione-based defense mechanisms.
Topics: Acute Disease; Amylases; Animals; Buthionine Sulfoximine; Female; Glutathione; Methionine Sulfoximine; Mice; Pancreas; Pancreatitis; Weight Gain | 1994 |
Characterization of benzo[a]pyrene quinone-induced toxicity to primary cultured bone marrow stromal cells from DBA/2 mice: potential role of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Anemia, Aplastic; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Benzo(a)pyrene; Benzopyrenes; Bone Marrow; Bone Marrow Cells; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Dicumarol; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Leukemia, Experimental; Male; Methionine Sulfoximine; Mice; Mice, Inbred DBA; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Quinones; Stromal Cells; Superoxide Dismutase; Thiones; Thiophenes | 1995 |
A protective effect of glutathione-dextran macromolecular conjugates on acetaminophen-induced hepatotoxicity dependent on molecular size.
Topics: Acetaminophen; Animals; Antimetabolites; Aspartate Aminotransferases; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Chromatography, High Pressure Liquid; Cyanogen Bromide; Delayed-Action Preparations; Dextrans; Disease Models, Animal; Drug Delivery Systems; Glutathione; In Vitro Techniques; Injections, Intravenous; Liver; Liver Diseases; Male; Methionine Sulfoximine; Mice; Molecular Weight; Survival Rate | 1994 |
De novo synthesis of glutathione is required for both entry into and progression through the cell cycle.
Topics: 3T3 Cells; Animals; Bisbenzimidazole; Bromodeoxyuridine; Buthionine Sulfoximine; Cell Cycle; Dose-Response Relationship, Drug; Ethidium; Flow Cytometry; Glutathione; Methionine Sulfoximine; Mice | 1995 |
Role of glutathione in macrophage activation: effect of cellular glutathione depletion on nitrite production and leishmanicidal activity.
Topics: Amino Acid Oxidoreductases; Animals; Buthionine Sulfoximine; Cells, Cultured; Enzyme Inhibitors; Female; Glutathione; Leishmaniasis; Macrophage Activation; Male; Maleates; Methionine Sulfoximine; Mice; Mice, Inbred CBA; Nitric Oxide; Nitric Oxide Synthase; Nitrites; RNA, Messenger | 1995 |
Buthionine sulfoximine pretreatment potentiates the effect of isolated lung perfusion with doxorubicin.
Topics: Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Chemotherapy, Cancer, Regional Perfusion; Doxorubicin; Drug Synergism; Glutathione; Hydroxyethyl Starch Derivatives; Liver; Lung Neoplasms; Male; Methionine Sulfoximine; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1995 |
Nitric oxide increases cellular glutathione levels in rat lung fibroblasts.
Topics: Animals; Arginine; Buthionine Sulfoximine; Cattle; Cell Line; Endothelium, Vascular; Enzyme Inhibitors; Fibroblasts; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Isosorbide Dinitrate; Lung; Methionine Sulfoximine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Pulmonary Artery; Rats; Vasodilator Agents | 1995 |
Modulation of cisplatin resistance in acquired-resistant nonsmall cell lung cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Carcinoma, Non-Small-Cell Lung; Cisplatin; DNA Repair; DNA, Neoplasm; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Glutathione; Glutathione Transferase; Humans; Intracellular Fluid; Lung Neoplasms; Methionine Sulfoximine; Pentoxifylline; Tumor Cells, Cultured | 1995 |
Plant defense metabolism is increased by the free radical-generating compound AAPH.
Topics: Amidines; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Dose-Response Relationship, Drug; Free Radicals; Glutathione; Glutathione Disulfide; Kinetics; Lipid Peroxidation; Methionine Sulfoximine; Phenols; Phenylalanine Ammonia-Lyase; Pisum sativum; Plant Physiological Phenomena; Plants | 1995 |
Cycloheximide and buthionine sulfoximine prevent induction of genotoxic adaptation by cadmium salt against methyl mercuric chloride in embryonic shoot cells of Hordum vulgare L.
Topics: Adaptation, Physiological; Buthionine Sulfoximine; Cadmium; Cadmium Compounds; Cycloheximide; Hordeum; Methionine Sulfoximine; Methylmercury Compounds; Micronuclei, Chromosome-Defective; Mitosis; Mitotic Index; Mutagenicity Tests; Plant Shoots; Seeds; Sulfates | 1995 |
Effects of glutathione depletion on the cytotoxic actions of cadmium in LLC-PK1 cells.
Topics: Animals; Buthionine Sulfoximine; Cadmium; Capillary Permeability; Cytoskeleton; Glutathione; LLC-PK1 Cells; Methionine Sulfoximine; Swine | 1995 |
[Therapeutic effectiveness of hyperthermia and relation to glutathione concentration in the tumor tissues].
Topics: Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Glutathione; Hyperthermia, Induced; Male; Methionine Sulfoximine; Neoplasms, Experimental; Rats | 1995 |
Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Buthionine Sulfoximine; Carcinoma, Ehrlich Tumor; Cell Division; Combined Modality Therapy; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Hydrogen-Ion Concentration; Male; Maleates; Methionine Sulfoximine; Mice; Radiation-Sensitizing Agents; X-Rays | 1995 |
Induction of metallothionein synthesis by glutathione depletion after trans- and cis-stilbene oxide administration in rats.
Topics: Animals; Buthionine Sulfoximine; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorocarbons; Glutathione; Glutathione Transferase; Kinetics; Liver; Male; Metallothionein; Methionine Sulfoximine; Rats; Rats, Wistar; RNA, Messenger; Stereoisomerism; Stilbenes; Zinc | 1995 |
Pentachlorophenol-induced oxidative DNA damage in mouse liver and protective effect of antioxidants.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amitrole; Animals; Antioxidants; Buthionine Sulfoximine; Deoxyguanosine; DNA Damage; Liver; Male; Methionine Sulfoximine; Mice; Oxidation-Reduction; Pentachlorophenol; Time Factors | 1995 |
Contribution of increased glutathione content to mechanisms of oxidative stress resistance in hydrogen peroxide resistant hamster fibroblasts.
Topics: Aldehydes; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Fibroblasts; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Oxidative Stress | 1995 |
Glutathione manipulation and the radiosensitivity of human tumour and fibroblast cell lines.
Topics: Buthionine Sulfoximine; Fibroblasts; Glutathione; Humans; Methionine Sulfoximine; Neoplasms; Radiation Tolerance; Tumor Cells, Cultured | 1995 |
Differential effects of depleting agents on cytoplasmic and nuclear non-protein sulphydryls: a fluorescence image cytometry study.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Nucleus; Cytoplasm; Glutathione; Humans; Methionine Sulfoximine; Microscopy, Fluorescence; Phenylmercury Compounds | 1995 |
Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein.
Topics: Biological Transport; Buthionine Sulfoximine; Daunorubicin; Drug Resistance, Multiple; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Rhodamine 123; Rhodamines; RNA, Messenger; Tumor Cells, Cultured | 1995 |
Profile of procarbazine-induced embryotoxicity in an embryo hepatocyte co-culture system and after in utero glutathione depletion.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Biotransformation; Buthionine Sulfoximine; Cells, Cultured; Embryo, Mammalian; Embryonic and Fetal Development; Female; Glutathione; Ketones; Liver; Male; Methionine Sulfoximine; Organ Culture Techniques; Pregnancy; Procarbazine; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
The effect of in utero administration of buthionine sulfoximine on rat development.
Topics: Abnormalities, Drug-Induced; Animals; Buthionine Sulfoximine; Embryonic and Fetal Development; Female; Glutamate-Cysteine Ligase; Glutathione; Maternal-Fetal Exchange; Methionine Sulfoximine; Pregnancy; Rats; Rats, Sprague-Dawley | 1995 |
Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels.
Topics: Acetylcysteine; Animals; Arsenic; Buthionine Sulfoximine; Female; Glutamate-Cysteine Ligase; Glutathione; Lipid Peroxidation; Methionine Sulfoximine; Rats; Rats, Wistar | 1995 |
Differential activation of heat-shock and oxidation-specific stress genes in chemically induced oxidative stress.
Topics: Animals; Base Sequence; Buthionine Sulfoximine; Gene Expression Regulation; Glutamate-Cysteine Ligase; HSP70 Heat-Shock Proteins; Ketones; Male; Methionine Sulfoximine; Molecular Sequence Data; Nitrofurantoin; Oxidative Stress; Rats; Rats, Wistar | 1995 |
ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Buthionine Sulfoximine; Cytoplasm; Daunorubicin; Fluoresceins; Glutathione; Humans; Indicators and Reagents; Methionine Sulfoximine; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Probenecid; Tumor Cells, Cultured | 1995 |
Buthionine sulfoximine-induced glutathione depletion. Its effect on antioxidants, lipid peroxidation and calcium homeostasis in the lung.
Topics: Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; Calcium; Glutamate-Cysteine Ligase; Glutathione; Lipid Peroxidation; Lung; Male; Methionine Sulfoximine; Rats; Rats, Wistar; Sulfhydryl Compounds | 1995 |
Evidence that glutathione is involved in thermotolerance of preimplantation murine embryos.
Topics: Animals; Blastocyst; Buthionine Sulfoximine; Embryonic Development; Female; Glutathione; Hot Temperature; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Morula; Pregnancy; Protein Biosynthesis; S-Adenosylmethionine | 1995 |
Cytotoxicity of antitumor platinum complexes with L-buthionine-(R,S)-sulfoximine and/or etanidazole in human carcinoma cell lines sensitive and resistant to cisplatin.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Buthionine Sulfoximine; Carboplatin; Cisplatin; Drug Resistance; Etanidazole; Female; Humans; Methionine Sulfoximine; Organoplatinum Compounds; Ovarian Neoplasms; Tumor Cells, Cultured | 1995 |
Methylene chloride-induced DNA damage: an interspecies comparison.
Topics: Animals; Buthionine Sulfoximine; CHO Cells; Cricetinae; DNA; DNA Damage; Dose-Response Relationship, Drug; Glutathione; Humans; Liver; Liver Neoplasms; Male; Mesocricetus; Methionine Sulfoximine; Methylene Chloride; Mice; Rats | 1995 |
Protective effects of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver.
Topics: Acetylcysteine; Acid Phosphatase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Buthionine Sulfoximine; Cold Temperature; Cysteine; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Oxidation-Reduction; Rats; Rats, Wistar; Reperfusion Injury | 1995 |
Glutathione redox cycle-driven recovery of reduced glutathione after oxidation by tertiary-butyl hydroperoxide in preimplantation mouse embryos.
Topics: Animals; Antimetabolites; Blastocyst; Buthionine Sulfoximine; Carmustine; Dose-Response Relationship, Drug; Female; Glutathione; Glutathione Disulfide; In Vitro Techniques; Kinetics; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Oxidation-Reduction; Peroxides; Reactive Oxygen Species; Superovulation; tert-Butylhydroperoxide | 1995 |
Markedly decreased expression of glutathione S-transferase pi gene in human cancer cell lines resistant to buthionine sulfoximine, an inhibitor of cellular glutathione synthesis.
Topics: Blotting, Southern; Buthionine Sulfoximine; DNA, Complementary; Drug Resistance; gamma-Glutamyltransferase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Humans; Methionine Sulfoximine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Transfection; Tumor Cells, Cultured | 1995 |
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Arsenites; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Buthionine Sulfoximine; Carcinoma, Non-Small-Cell Lung; Cell Division; Cysteine; Drug Resistance, Multiple; Glutathione; Humans; Kinetics; Lung Neoplasms; Methionine Sulfoximine; Multidrug Resistance-Associated Proteins; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 1995 |
Glutathione depletion in human T lymphocytes: analysis of activation-associated gene expression and the stress response.
Topics: Antimetabolites, Antineoplastic; Blotting, Northern; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; DNA; DNA Probes; Down-Regulation; Gene Expression Regulation; Glutamate-Cysteine Ligase; Glutathione; HSP70 Heat-Shock Proteins; Humans; Lymphocyte Activation; Methionine Sulfoximine; Oxidative Stress; RNA, Messenger; T-Lymphocytes | 1995 |
Noninvasive measurement of thiol levels in cells and isolated organs.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; CHO Cells; Cricetinae; Dithionitrobenzoic Acid; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Indicators and Reagents; Methionine Sulfoximine; Myocardial Ischemia; Myocardium; Proteins; Spin Labels; Sulfhydryl Compounds | 1995 |
N-ras mRNA expression is unaffected in glutathione-depleted cells of hematopoietic origin.
Topics: Buthionine Sulfoximine; Gene Expression; Genes, ras; Glutathione; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Methionine Sulfoximine; RNA, Messenger; T-Lymphocytes; Tumor Cells, Cultured | 1995 |
[Use of inhibitors of glutathione and glutathione transferase for overcoming resistance of tumor to cytostatics in an in vivo system].
Topics: Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Glutathione; Glutathione Transferase; Leukemia P388; Male; Methionine Sulfoximine; Mice; Tumor Cells, Cultured | 1995 |
Cigarette smoke, glutathione metabolism and epithelial permeability in rat lungs.
Topics: Animals; Buthionine Sulfoximine; Cell Membrane Permeability; Epithelium; Glucosephosphate Dehydrogenase; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Homeostasis; Lung; Methionine Sulfoximine; Rats; Rats, Wistar; Smoke; Smoking | 1995 |
The role of thiols in oxidation of low-density lipoprotein by macrophages.
Topics: Antimetabolites; Buthionine Sulfoximine; Carmustine; Cell Line; Cell-Free System; Cystine; Humans; Kinetics; Lipoproteins, LDL; Macrophages; Methionine Sulfoximine; Oxidation-Reduction; S-Adenosylmethionine; Sulfhydryl Compounds; Thiobarbituric Acid Reactive Substances; Tubercidin | 1995 |
Radiosensitization of mouse skin by oxygen and depletion of glutathione.
Topics: Animals; Buthionine Sulfoximine; Carbon Dioxide; Cell Hypoxia; Dose-Response Relationship, Radiation; Female; Glutathione; Male; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Oxygen; Oxygen Consumption; Partial Pressure; Radiation-Sensitizing Agents; Skin; Tourniquets | 1995 |
p21ras as a common signaling target of reactive free radicals and cellular redox stress.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Enzyme Activation; Free Radicals; Glutamate-Cysteine Ligase; Humans; Methionine Sulfoximine; NF-kappa B; Oncogene Protein p21(ras); Oxidation-Reduction; Oxidative Stress; PC12 Cells; Protein Kinases; Rats; Signal Transduction | 1995 |
Buthionine sulfoximine mediated enhancement of gamma-radiation induced mutation frequency in Drosophila melanogaster.
Topics: Animals; Buthionine Sulfoximine; Drosophila melanogaster; Gamma Rays; Genes, Lethal; Genetic Linkage; Glutathione; Larva; Male; Methionine Sulfoximine; Mutagens; Mutation; Radiation-Sensitizing Agents | 1993 |
Normal Ca2+ signalling in glutathione-depleted and dithiothreitol-treated HeLa cells.
Topics: Antimetabolites; Buthionine Sulfoximine; Calcium; Cytosol; Dithiothreitol; Glutathione; HeLa Cells; Histamine; Histamine Release; Humans; Methionine Sulfoximine; Microscopy, Fluorescence; Signal Transduction; Terpenes; Thapsigargin | 1993 |
In vivo production of different chloroform metabolites: effect of phenobarbital and buthionine sulfoximine pretreatment.
Topics: Animals; Buthionine Sulfoximine; Chloroform; Injections, Intraperitoneal; Male; Methionine Sulfoximine; Microsomes, Liver; Phenobarbital; Phospholipids; Rats; Rats, Sprague-Dawley | 1994 |
Nitric oxide-induced cytotoxicity: involvement of cellular resistance to oxidative stress and the role of glutathione in protection.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Glutathione; Methionine Sulfoximine; Models, Biological; Nitric Oxide; Oxidative Stress | 1995 |
Glutathione metabolism in Crohn's disease.
Topics: Administration, Oral; Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Crohn Disease; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Transferase; Humans; Ileum; Isoxazoles; Jejunum; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley | 1994 |
Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Buthionine Sulfoximine; Cell Line; Cell Survival; Drug Resistance, Multiple; Etoposide; Female; Glutathione; Humans; Kinetics; Methionine Sulfoximine; Tumor Cells, Cultured; Vincristine | 1995 |
Styrene-induced hepatotoxicity in mice depleted of glutathione.
Topics: Alanine Transaminase; Animals; Antimetabolites; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Glutathione; Liver Diseases; Male; Methionine Sulfoximine; Mice; Oxygenases; Styrene; Styrenes; Sulfhydryl Compounds | 1994 |
Differential effects of ifosfamide on the capacity of cytotoxic T lymphocytes and natural killer cells to lyse their target cells correlate with intracellular glutathione levels.
Topics: Antibodies, Monoclonal; Antigens, CD; Buthionine Sulfoximine; CD3 Complex; Cells, Cultured; Cytotoxicity, Immunologic; Glutathione; Humans; Ifosfamide; Interleukin-2; Intracellular Fluid; Killer Cells, Natural; Lymphocyte Activation; Mesna; Methionine Sulfoximine; T-Lymphocytes, Cytotoxic | 1995 |
Cytotoxicity of mercury compounds in LLC-PK1, MDCK and human proximal tubular cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Dogs; Drug Interactions; Glutathione; Humans; Kidney; Kidney Tubules, Proximal; LLC-PK1 Cells; Mercury Compounds; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Spectrophotometry, Atomic; Swine; Thiazoles; Thiazolidines | 1995 |
Synthesis of glutathione in the preimplantation mouse embryo.
Topics: Animals; Antimetabolites; Blastocyst; Buthionine Sulfoximine; Culture Media; Cycloheximide; Cystine; Female; Glutathione; In Vitro Techniques; Maleates; Methionine; Methionine Sulfoximine; Mice; Pregnancy | 1995 |
Glutathione depletion potentiates 12-O-tetradecanoyl phorbol-13-acetate(TPA)-induced inhibition of gap junctional intercellular communication in WB-F344 rat liver epithelial cells: relationship to intracellular oxidative stress.
Topics: Animals; Benzoyl Peroxide; Buthionine Sulfoximine; Cell Communication; Cells, Cultured; Drug Synergism; Epithelium; Gap Junctions; Glutamate-Cysteine Ligase; Glutathione; Liver; Methionine Sulfoximine; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate | 1995 |
The antioxidant N-acetyl-cysteine protects cultured epithelial cells from menadione-induced cytopathology.
Topics: Acetylcysteine; Antimetabolites; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Cell Adhesion; Epithelium; Glutamate-Cysteine Ligase; Humans; Methionine Sulfoximine; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Oxidative Stress; Tumor Cells, Cultured; Vitamin K | 1995 |
Mechanism of cross-resistance to cisplatin in a mitomycin C-resistant human bladder cancer cell line.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Buthionine Sulfoximine; Cadmium; Cadmium Chloride; Carboplatin; Cell Line; Cell Survival; Chlorides; Cisplatin; Drug Resistance; Gene Expression; Glutathione; Glutathione Transferase; Humans; Isoenzymes; Kinetics; Metallothionein; Methionine Sulfoximine; Mitomycin; RNA, Messenger; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1995 |
Glutathione conjugation of bromosulfophthalein in relation to hepatic glutathione content in the rat in vivo and in the perfused rat liver.
Topics: Animals; Buthionine Sulfoximine; Glutathione; Infusions, Intravenous; Liver; Male; Maleates; Methionine Sulfoximine; Perfusion; Rats; Rats, Wistar; Sulfobromophthalein | 1995 |
Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration.
Topics: Animals; Aspartic Acid; Brain; Buthionine Sulfoximine; Glutathione; Methionine Sulfoximine; Mitochondria; Neurons; Rats | 1995 |
Effects of buthionine sulfoximine (BSO) on mercury distribution after Hg(o) exposure.
Topics: Analysis of Variance; Animals; Buthionine Sulfoximine; Drug Interactions; Glutamate-Cysteine Ligase; Glutathione; Lipid Peroxidation; Male; Mercury; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Oxidative Stress; Thiobarbituric Acid Reactive Substances | 1995 |
Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells.
Topics: Acetylcysteine; Asbestos, Crocidolite; Buthionine Sulfoximine; Genes, fos; Genes, jun; Glutathione; Humans; Methionine Sulfoximine; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Superoxide Dismutase | 1995 |
Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats.
Topics: Animals; Buthionine Sulfoximine; Cataract; Female; Free Radicals; Glutamate-Cysteine Ligase; Glutathione; Humans; Infant, Newborn; Lenses; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Thioctic Acid | 1995 |
Drug resistance mechanisms and MRP expression in response to epirubicin treatment in a human leukaemia cell line.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Buthionine Sulfoximine; Cell Line; Cell Survival; Drug Resistance, Multiple; Epirubicin; Gene Expression; Humans; In Vitro Techniques; Methionine Sulfoximine; Multidrug Resistance-Associated Proteins; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Verapamil | 1995 |
Polyunsaturated fatty acid enrichment increases ultraviolet A-induced lipid peroxidation in NCTC 2544 human keratinocytes.
Topics: Antimetabolites; Antioxidants; Arachidonic Acid; Ascorbic Acid; Buthionine Sulfoximine; Cell Count; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Keratinocytes; Lipid Peroxidation; Methionine Sulfoximine; Thiobarbituric Acid Reactive Substances; Ultraviolet Rays; Vitamin E | 1995 |
Deleterious effects of buthionine sulfoximine on cardiac function during continuous endotoxemia.
Topics: Animals; Bacterial Toxins; Buthionine Sulfoximine; Cardiac Output; Coronary Circulation; Endotoxins; Female; Free Radicals; Glutathione; Heart; Heart Rate; Male; Methionine Sulfoximine; Myocardial Contraction; Salmonella enteritidis; Swine | 1995 |
Cadmium-sensitive, cad1 mutants of Arabidopsis thaliana are phytochelatin deficient.
Topics: Alleles; Aminoacyltransferases; Arabidopsis; Buthionine Sulfoximine; Cadmium; Drug Resistance; Genes, Plant; Glutathione; Inactivation, Metabolic; Metalloproteins; Methionine Sulfoximine; Mutation; Peptidyl Transferases; Phytochelatins; Plant Proteins | 1995 |
Esophagitis in Sprague-Dawley rats is mediated by free radicals.
Topics: Animals; Buthionine Sulfoximine; Disease Models, Animal; Drug Evaluation, Preclinical; Esophagitis, Peptic; Esophagus; Free Radical Scavengers; Free Radicals; Glutamate-Cysteine Ligase; Glutathione; Linear Models; Male; Methionine Sulfoximine; Mucous Membrane; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Superoxide Dismutase; Time Factors | 1995 |
Sodium valproate, an anticonvulsant drug, stimulates human cytomegalovirus replication.
Topics: Anticonvulsants; Antigens, Viral; Antimetabolites; Buthionine Sulfoximine; Cell Line; Cytomegalovirus; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Glutathione; Humans; Immediate-Early Proteins; Kinetics; Methionine Sulfoximine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Valproic Acid; Virus Replication | 1995 |
Liver and kidney necrosis in selenium-deficient rats depleted of glutathione.
Topics: Animals; Buthionine Sulfoximine; Dinoprost; Glutathione; Ketones; Kidney; Lipid Peroxides; Liver; Male; Maleates; Methionine Sulfoximine; Necrosis; Osmolar Concentration; Proteins; Rats; Rats, Sprague-Dawley; Selenium; Selenoprotein P; Selenoproteins | 1995 |
Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells.
Topics: Aldehyde Dehydrogenase; Aldehydes; Breast Neoplasms; Buthionine Sulfoximine; Cell Line; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Resistance; Ethacrynic Acid; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Humans; Methionine Sulfoximine | 1995 |
A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress.
Topics: Buthionine Sulfoximine; Carbon-Oxygen Lyases; Cell Hypoxia; Cell Survival; DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gene Expression Regulation, Enzymologic; Glutathione; HeLa Cells; Humans; Methionine Sulfoximine; Mutagens; Nuclear Proteins; Oxidative Stress; Proto-Oncogene Mas; RNA, Antisense; Ultraviolet Rays | 1994 |
Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication.
Topics: Acetylcysteine; Antimetabolites; Antioxidants; Antiviral Agents; Buthionine Sulfoximine; Cells, Cultured; Free Radical Scavengers; Gene Expression Regulation, Viral; Genes, Reporter; Glutathione; HIV Long Terminal Repeat; HIV-1; Humans; Leukocytes, Mononuclear; Methionine Sulfoximine; Monocytes; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha; Virus Replication | 1994 |
[Induction and prevention of kidney injury induced by GSH depletion and vitamin E deficiency in rats].
Topics: Animals; Ascorbic Acid; Buthionine Sulfoximine; Chromans; Glutathione; Kidney Tubular Necrosis, Acute; Male; Methionine Sulfoximine; Rats; Rats, Wistar; Vitamin E; Vitamin E Deficiency | 1994 |
Development of extended multidrug resistance in HL60 promyelocytic leukaemia cells.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Drug Resistance, Multiple; Epirubicin; Humans; Leukemia, Promyelocytic, Acute; Methionine Sulfoximine; Tretinoin; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |
Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Bile; Buthionine Sulfoximine; Ethylene Chlorohydrin; Glutathione; Liver; Male; Maleates; Methionine Sulfoximine; Monocrotaline; Perfusion; Pyrroles; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1995 |
Reductant substrate for glutathione peroxidase modulates oxidant inhibition of Ca2+ signaling in endothelial cells.
Topics: Animals; Bradykinin; Buthionine Sulfoximine; Calcium; Cattle; Cells, Cultured; Dinitrochlorobenzene; Dithionitrobenzoic Acid; Egtazic Acid; Endothelium, Vascular; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Kinetics; Methionine Sulfoximine; Oxidants; Peroxides; Pulmonary Artery; Signal Transduction; tert-Butylhydroperoxide; Time Factors | 1995 |
Human (THP-1) macrophages oxidize LDL by a thiol-dependent mechanism.
Topics: Buthionine Sulfoximine; Copper; Cysteine; Cystine; Glutathione; Humans; Lipoproteins, LDL; Macrophages; Methionine Sulfoximine; Oxidation-Reduction; Tumor Cells, Cultured | 1994 |
Disposition of glutathione monoethyl ester in the rat: glutathione ester is a slow release form of extracellular glutathione.
Topics: Animals; Buthionine Sulfoximine; Glutathione; Half-Life; Hydrolysis; Liver; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley | 1995 |
A glutathione depletion selectively imposed on mu glutathione S-transferase overproducing cells increases nitrogen mustard toxicity.
Topics: Animals; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; Cisplatin; Cricetinae; Cricetulus; Doxorubicin; Glutathione; Glutathione Transferase; Inactivation, Metabolic; Mechlorethamine; Methionine Sulfoximine | 1995 |
Buthionine sulfoximine induced cataracts in mice contain insolubilized crystallins with calpain II cleavage sites.
Topics: Amino Acid Sequence; Animals; Buthionine Sulfoximine; Calpain; Cataract; Crystallins; Enzyme Activation; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Molecular Sequence Data; Solubility | 1994 |
Effect of buthionine sulfoximine on the sensitivity to doxorubicin of parent and MDR tumor cell lines.
Topics: Animals; Buthionine Sulfoximine; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Glutathione; Humans; Methionine Sulfoximine; Mice; Tumor Cells, Cultured; Vincristine | 1994 |
Glutathione depletion in rested and exercised mice: biochemical consequence and adaptation.
Topics: Adaptation, Physiological; Animals; Body Weight; Buthionine Sulfoximine; Glutamate-Cysteine Ligase; Glutathione; Homeostasis; Kidney; Liver; Male; Methionine Sulfoximine; Mice; Models, Biological; Muscle, Skeletal; Oxidative Stress; Physical Conditioning, Animal; Physical Endurance; Rest | 1995 |
Exercise-induced oxidative stress: glutathione supplementation and deficiency.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Glutathione; Heart; Injections, Intraperitoneal; Kidney; Lipid Peroxides; Liver; Lung; Male; Methionine Sulfoximine; Muscle, Skeletal; Myocardium; Oxidative Stress; Physical Exertion; Random Allocation; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 1994 |
Inhibitory effect of melatonin on cataract formation in newborn rats: evidence for an antioxidative role for melatonin.
Topics: Animals; Animals, Newborn; Antioxidants; Brain; Buthionine Sulfoximine; Cataract; Free Radical Scavengers; Glutathione; Lens, Crystalline; Melatonin; Methionine Sulfoximine; Oxidative Stress; Rats | 1994 |
Effect of glutathione on sister-chromatid exchanges in normal and buthionine sulfoximine-treated mice.
Topics: Animals; Bone Marrow; Buthionine Sulfoximine; Catalase; Cell Cycle; DNA Damage; Glutamate-Cysteine Ligase; Glutathione; Hydrogen Peroxide; Male; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Sister Chromatid Exchange | 1995 |
Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Glutamate-Cysteine Ligase; Glutathione; Mercuric Chloride; Methionine Sulfoximine; Methylmercury Compounds; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Taurine; Thiazoles; Thiazolidines; Tritium | 1994 |
Role of nerve growth factor in oxidant homeostasis: glutathione metabolism.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Free Radicals; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Homeostasis; Kinetics; Methionine Sulfoximine; Nerve Growth Factors; Nerve Tissue Proteins; Neurotrophin 3; Oxidants; PC12 Cells; Prostaglandins D; Somatomedins | 1993 |
Glutathione depletion increases tyrosinase activity in human melanoma cells.
Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Glutathione; Humans; Melanins; Melanoma; Methionine Sulfoximine; Monophenol Monooxygenase; Sulfhydryl Compounds; Time Factors; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1993 |
Differential effect of cyanohydroxybutene on glutathione synthesis in liver and pancreas of male rats.
Topics: Alkenes; Animals; Base Sequence; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Liver; Male; Methionine Sulfoximine; Molecular Sequence Data; Nitriles; Pancreas; Plant Extracts; Rats; Rats, Inbred F344; RNA, Messenger | 1993 |
Cystine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-alpha-aminoadipate toxicity.
Topics: 2-Aminoadipic Acid; Animals; Antimetabolites; Autoradiography; Buthionine Sulfoximine; Carps; Carrier Proteins; Chlorides; Chromatography, High Pressure Liquid; Cystine; Electroretinography; Glutamates; Glutamic Acid; Glutathione; Isomerism; Methionine Sulfoximine; Neuroglia; Retina; Sodium; Sulfur Radioisotopes | 1993 |
Buthionine sulfoximine treatment impairs rat diaphragm function.
Topics: Analysis of Variance; Animals; Buthionine Sulfoximine; Diaphragm; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Male; Methionine Sulfoximine; Muscle Contraction; Rats; Rats, Sprague-Dawley; Respiratory Function Tests | 1994 |
Nephrotoxicity mechanism of cis-platinum (II) diamine dichloride in mice.
Topics: Alkaline Phosphatase; Aminooxyacetic Acid; Animals; Buthionine Sulfoximine; Cisplatin; Drug Synergism; gamma-Glutamyltransferase; Glutathione; Injections, Intraperitoneal; Injections, Subcutaneous; Isoxazoles; Kidney Tubules, Proximal; Male; Methimazole; Methionine Sulfoximine; Mice; Probenecid | 1994 |
Protection of cultured rat gastric cells against oxidant-induced damage by exogenous glutathione.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Chromium Radioisotopes; Cysteine; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Glucose; Glucose Oxidase; Glutamate-Cysteine Ligase; Glutathione; Hydrogen Peroxide; Isoxazoles; Male; Methionine Sulfoximine; Protein Precursors; Rats; Rats, Sprague-Dawley; Resting Phase, Cell Cycle; Stomach | 1994 |
Modulation of gamma-glutamylcysteine synthetase large subunit mRNA expression by butylated hydroxyanisole.
Topics: Animals; Base Sequence; Buthionine Sulfoximine; Butylated Hydroxyanisole; Diet; DNA, Complementary; Fasting; Gene Expression Regulation, Enzymologic; Glutamate-Cysteine Ligase; Glutathione; Ketones; Liver; Male; Maleates; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Molecular Sequence Data; RNA, Messenger | 1994 |
Pharmacodynamics of prolonged treatment with L,S-buthionine sulfoximine.
Topics: 3T3 Cells; Animals; Antimetabolites; Brachytherapy; Buthionine Sulfoximine; Cell Line; CHO Cells; Cricetinae; Etanidazole; Glutamate-Cysteine Ligase; Glutathione; Humans; Male; Methionine Sulfoximine; Mice; Mice, Nude; Radiation-Sensitizing Agents | 1994 |
Influence of intracellular glutathione concentration of lipofuscin accumulation in cultured neonatal rat cardiac myocytes.
Topics: Animals; Animals, Newborn; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Female; Glutamate-Cysteine Ligase; Glutathione; Heart; Kinetics; Lipid Peroxidation; Lipofuscin; Male; Methionine Sulfoximine; Microscopy, Electron; Models, Biological; Myocardium; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley | 1994 |
A role for gamma-glutamyl transpeptidase in the transport of cystine into human endothelial cells: relationship to intracellular glutathione.
Topics: Amino Acid Transport Systems; Amino Acids; Biological Transport; Buthionine Sulfoximine; Carrier Proteins; Cells, Cultured; Cystine; Endothelium, Vascular; gamma-Glutamyltransferase; Glutamates; Glutathione; Humans; Isoxazoles; Methionine Sulfoximine | 1994 |
Biochemical regulation of the activity of gamma-glutamylcysteine synthetase from rat liver and kidney by glutathione.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cystamine; Electrophoresis, Polyacrylamide Gel; Glutamate-Cysteine Ligase; Glutathione; Kidney; Kinetics; Liver; Methionine Sulfoximine; Molecular Weight; Organ Specificity; Rats | 1994 |
Role of gamma-glutamyltranspeptidase-mediated glutathione transport on the radiosensitivity of B16 melanoma variant cell lines.
Topics: Animals; Biological Transport; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutathione; Melanoma, Experimental; Methionine Sulfoximine; Mice; Radiation Tolerance; Tumor Cells, Cultured | 1994 |
Effect of selenium deficiency and glutathione-modulating agents on diquat toxicity and lipid peroxidation in rats.
Topics: Animals; Antimetabolites; Arachidonic Acids; Buthionine Sulfoximine; Carmustine; Diquat; Glutathione; Ketones; Kidney; Lipid Peroxidation; Liver; Lung; Male; Methionine Sulfoximine; Rats; Rats, Inbred F344; Selenium | 1994 |
Human larynx carcinoma cells resistant to cis-diamminedichloroplatinum(II): mechanisms involved in the resistance.
Topics: Buthionine Sulfoximine; Cadmium; Cadmium Chloride; Cell Cycle; Chlorides; Cisplatin; Clone Cells; Drug Resistance; Ethacrynic Acid; Glutathione; Humans; Laryngeal Neoplasms; Methionine Sulfoximine; Tumor Cells, Cultured | 1994 |
Role of glutathione in cyclosporine A in vitro hepatotoxicity.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Cyclosporine; Dithiothreitol; Dose-Response Relationship, Drug; Glutathione; Kinetics; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Male; Methionine Sulfoximine; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 1994 |
Neuroprotection by glial cells through adult T cell leukemia-derived factor/human thioredoxin (ADF/TRX).
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Astrocytoma; Blotting, Western; Brain Neoplasms; Buthionine Sulfoximine; Cell Survival; Cerebral Cortex; Cytokines; Glutathione; Growth Substances; Humans; Hydrogen Peroxide; Mercaptoethanol; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Neoplasm Proteins; Neuroglia; Thioredoxins; Tumor Cells, Cultured | 1994 |
Glutathione stimulates A549 cell proliferation in glutamine-deficient culture: the effect of glutamate supplementation.
Topics: Buthionine Sulfoximine; Cell Division; Cysteine; gamma-Glutamyltransferase; Glutamates; Glutamine; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Tumor Cells, Cultured | 1994 |
Intracellular glutathione influences collagen generation by mesangial cells.
Topics: Acetylcysteine; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Transformation, Viral; Cells, Cultured; Collagen; Culture Media; Glomerular Mesangium; Glucose; Glutathione; Methionine Sulfoximine; Mice; Oxidation-Reduction; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta | 1994 |
Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Dithiothreitol; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Mice; Sulfhydryl Compounds | 1994 |
Lead toxicity via arachidonate signal transduction to growth responses in the splenic macrophage.
Topics: Animals; Arachidonic Acid; Buthionine Sulfoximine; Cycloheximide; Dinoprostone; Lead; Lipopolysaccharides; Macrophages; Methionine Sulfoximine; Mice; Signal Transduction; Spleen | 1994 |
Altered oxidative stress responses in nickel-resistant mammalian cells.
Topics: 3T3 Cells; Animals; Buthionine Sulfoximine; Cell Survival; Drug Resistance; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; NF-kappa B; Nickel; Oxidative Stress; Transcription Factor AP-1; Vitamin K | 1994 |
Mechanisms of endotoxin-induced haem oxygenase mRNA accumulation in mouse liver: synergism by glutathione depletion and protection by N-acetylcysteine.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Escherichia coli; Glutathione; Heme Oxygenase (Decyclizing); Lipopolysaccharides; Liver; Male; Methionine Sulfoximine; Mice; Oxidative Stress; RNA, Messenger; S-Adenosylmethionine | 1994 |
Two pathways for chromium(VI)-induced DNA damage in 14 day chick embryos: Cr-DNA binding in liver and 8-oxo-2'-deoxyguanosine in red blood cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Ascorbic Acid; Buthionine Sulfoximine; Chick Embryo; Chromium Compounds; Cross-Linking Reagents; Deoxyguanosine; DNA Damage; Dose-Response Relationship, Drug; Erythrocytes; Glutathione; Liver; Methionine Sulfoximine; Oxidation-Reduction; Pentetic Acid | 1994 |
An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro.
Topics: Animals; Antimetabolites; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; Cattle; Cell Line; Cell Membrane Permeability; Cells, Cultured; Epithelium; Glutathione; Humans; In Vitro Techniques; Intracellular Fluid; Iodine Radioisotopes; Leukocyte Count; Leukocytes; Methionine Sulfoximine; Neutrophils; Pulmonary Alveoli; Rats; Rats, Wistar; Serum Albumin, Bovine; Smoking; Time Factors | 1994 |
Prostaglandin E2 suppresses phytohemagglutinin-induced immune responses of normal human mononuclear cells by decreasing intracellular glutathione generation, but not due to increased DNA strand breaks or apoptosis.
Topics: Antimetabolites; Apoptosis; Bucladesine; Buthionine Sulfoximine; CD4-CD8 Ratio; Cell Cycle; Dinoprostone; DNA Damage; Enzyme-Linked Immunosorbent Assay; Glutathione; Humans; Immunity, Cellular; In Vitro Techniques; Lymphocyte Activation; Methionine Sulfoximine; Monocytes; Phytohemagglutinins; Receptors, Interleukin-2; Thymidine | 1993 |
Evaluation of methods for measuring cellular glutathione content using flow cytometry.
Topics: Animals; Breast Neoplasms; Bridged Bicyclo Compounds; Buthionine Sulfoximine; Carcinoma; Carcinosarcoma; CHO Cells; Colonic Neoplasms; Cricetinae; Ethylmaleimide; Eukaryotic Cells; Evaluation Studies as Topic; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Glutathione; Humans; Maleates; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Mice; o-Phthalaldehyde; Phenylmercury Compounds; Pyrazoles; Species Specificity; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cells, Cultured; Cerebral Cortex; Cycloheximide; Cysteine; Glutamates; Glutathione; Homocysteine; Macromolecular Substances; Methionine Sulfoximine; Neurons; Oxidants; Protein Biosynthesis; Proteins; Rats | 1994 |
The role of glucose in cellular defences against cytotoxicity of hydrogen peroxide in Chinese hamster ovary cells.
Topics: Amitrole; Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Catalase; Cell Survival; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Glucose; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Pentose Phosphate Pathway | 1994 |
Sensitive enzymatic cycling assay for glutathione: measurements of glutathione content and its modulation by buthionine sulfoximine in vivo and in vitro in human colon cancer.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Colonic Neoplasms; Female; Glutathione; Humans; Kidney; Liver; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Nude; Rats; Rats, Sprague-Dawley; Reference Values; Transplantation, Heterologous; Tumor Cells, Cultured | 1994 |
[Potentiation of cisplatin sensitivity of cisplatin-resistant human ovarian cancer cell lines by L-buthionine-S,R-sulfoximine].
Topics: Adenocarcinoma; Adult; Buthionine Sulfoximine; Cisplatin; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Methionine Sulfoximine; Middle Aged; Ovarian Neoplasms; Tumor Cells, Cultured | 1994 |
Radiation resistance in a melphalan-resistant subline of a rat mammary carcinoma.
Topics: Animals; Buthionine Sulfoximine; Cell Cycle; Cell Division; Cell Survival; Drug Resistance; Glutathione Peroxidase; Glutathione Transferase; Mammary Neoplasms, Experimental; Melphalan; Methionine Sulfoximine; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Tumor Cells, Cultured | 1994 |
A model for fatal halothane hepatitis in the guinea pig.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Guinea Pigs; Halothane; Liver; Male; Methionine Sulfoximine; Necrosis | 1994 |
Buthionine sulfoximine spares intracellular glutamate: a possible mechanism for cell growth stimulation.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Division; Cell Line; Chromatography, High Pressure Liquid; DNA Replication; Glutamates; Glutathione; Humans; Kinetics; Lung Neoplasms; Methionine Sulfoximine; Thymidine; Tumor Cells, Cultured | 1993 |
Significance of the proportion of binucleate cells in the micronucleus assay: a methodological study.
Topics: Animals; Buthionine Sulfoximine; Cell Count; Cell Nucleus; Cricetinae; Cricetulus; Cytochalasin B; Methionine Sulfoximine; Micronucleus Tests | 1994 |
Effect of GSH depletion mediated by l-BSO on the insecticidal activity of DDT and fenitrothion in Triatoma infestans (Hemiptera).
Topics: Animals; Buthionine Sulfoximine; DDT; Fenitrothion; Glutathione; Methionine Sulfoximine; Pesticide Synergists; Triatoma | 1994 |
Antisera to glutathione: characterization and immunocytochemical application to the rat cerebellum.
Topics: Animals; Antibody Specificity; Buthionine Sulfoximine; Cerebellum; Cross Reactions; Glutathione; Immune Sera; Immunization; Immunohistochemistry; Methionine Sulfoximine; Microscopy, Immunoelectron; Neurons; Organelles; Rabbits; Rats | 1994 |
Methylene chloride: an inhalation study to investigate toxicity in the mouse lung using morphological, biochemical and Clara cell culture techniques.
Topics: Administration, Inhalation; Animals; Antimetabolites; Bronchi; Buthionine Sulfoximine; Cell Division; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytosol; Epithelium; Glutathione; Glutathione Transferase; Male; Methionine Sulfoximine; Methylene Chloride; Mice; Microsomes; Piperonyl Butoxide; Vacuoles | 1994 |
Effect of sulfhydryl compounds and glutathione depletion on rat heart myocyte toxicity induced by 4-hydroperoxycyclophosphamide and acrolein in vitro.
Topics: Acrolein; Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cyclophosphamide; Glutathione; Heart; In Vitro Techniques; Methionine Sulfoximine; Muscle Proteins; Rats; Sulfhydryl Compounds | 1994 |
The gold anti-rheumatic drug auranofin governs T cell activation by enhancing oxygen free radical production.
Topics: Auranofin; Buthionine Sulfoximine; Cells, Cultured; Deferoxamine; Flow Cytometry; Glutathione; Humans; Interleukin-2; Lymphocyte Activation; Methionine Sulfoximine; Phytohemagglutinins; Reactive Oxygen Species; T-Lymphocytes; Thymidine | 1994 |
Glutathione cycle dependency of ferric nitrilotriacetate-induced lipid peroxidation in mouse proximal renal tubules.
Topics: Aging; Animals; Buthionine Sulfoximine; Cysteine; Fatty Acids; Fatty Acids, Unsaturated; Female; Ferric Compounds; gamma-Glutamyltransferase; Glutathione; Glutathione Synthase; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Lipid Peroxidation; Male; Methionine Sulfoximine; Mice; Nitrilotriacetic Acid; Sex Characteristics; Thiobarbiturates | 1993 |
P-glycoprotein and alterations in the glutathione/glutathione-peroxidase cycle underlie doxorubicin resistance in HL-60-R, a subclone of the HL-60 human leukemia cell line.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Flow Cytometry; Glutathione; Glutathione Peroxidase; Humans; Leukemia, Myeloid, Acute; Membrane Glycoproteins; Methionine Sulfoximine; Tumor Cells, Cultured; Verapamil | 1993 |
Effect of L-buthionine sulfoximine on the radiation response of human renal carcinoma cell lines.
Topics: Animals; Buthionine Sulfoximine; Carcinoma, Renal Cell; Cell Adhesion; Cell Division; Cell Survival; Glutamate-Cysteine Ligase; Glutathione; Humans; Kidney Neoplasms; Male; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Nude; Phenotype; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1993 |
Post-irradiation modification of O2, N2, and N2O-mediated damage in dry barley seeds by glutathione and cysteine: probable radiation chemical events.
Topics: Buthionine Sulfoximine; Cobalt Radioisotopes; Cysteine; Gamma Rays; Glutathione; Hordeum; Methionine Sulfoximine; Nitrogen; Nitrous Oxide; Oxygen; Radiation-Protective Agents; Seeds; Water | 1993 |
Glutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity.
Topics: Buthionine Sulfoximine; Cell Cycle; Cell Survival; Female; Fluorescent Antibody Technique; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Microtubules; Paclitaxel; Tumor Cells, Cultured | 1993 |
A comparative study of the toxicity of chemically reactive xenobiotics towards adherent cell cultures: selective attenuation of menadione toxicity by buthionine sulphoximine pretreatment.
Topics: Animals; Antimetabolites; Benzoquinones; Buthionine Sulfoximine; Cell Adhesion; Cell Survival; Fluoresceins; Fluorescent Dyes; Glutathione; Imines; Methionine Sulfoximine; Mice; Tumor Cells, Cultured; Vitamin K | 1993 |
Multifactorial molecular mechanisms are involved in resistance of preirradiated human cervix carcinoma cells to cis-dichlorodiammineplatinum (II) and vincristine.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cadmium; Cadmium Chloride; Carrier Proteins; Chlorides; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance; Ethacrynic Acid; Female; Gamma Rays; Glutathione; Glutathione Transferase; HeLa Cells; Humans; Membrane Glycoproteins; Metallothionein; Methionine Sulfoximine; Ultraviolet Rays; Uterine Cervical Neoplasms; Verapamil; Vincristine | 1993 |
Differences in the glutathione system of cultured aortic smooth muscle cells from young and aged rats.
Topics: Aging; Animals; Aorta, Thoracic; Buthionine Sulfoximine; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Methionine Sulfoximine; Muscle, Smooth, Vascular; Rats; Sulfhydryl Compounds | 1993 |
Buthionine sulfoximine reduces the protective capacity of myocytes to withstand peroxide-derived free radical attack.
Topics: Animals; Benzene Derivatives; Buthionine Sulfoximine; Cell Death; Cells, Cultured; Free Radicals; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Heart; Heart Rate; Lipid Peroxidation; Methionine Sulfoximine; Myocardium; NADP; Rats; Rats, Wistar | 1993 |
Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line.
Topics: Ammonium Sulfate; Antibodies; Astrocytoma; Blotting, Western; Buthionine Sulfoximine; Cell Line; Chemical Fractionation; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glutamate-Cysteine Ligase; Glutathione; Humans; Immunohistochemistry; Methionine Sulfoximine; Molecular Weight; Neutralization Tests | 1993 |
High-performance liquid chromatographic determination of the S- and R-diastereoisomers of L-buthionine (SR)-sulfoximine in human plasma and urine.
Topics: Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Humans; Isothiocyanates; Methionine Sulfoximine; Norleucine; Sensitivity and Specificity; Stereoisomerism; Thiocyanates; Ultrafiltration | 1993 |
Evidence for embryonic peroxidase-catalyzed bioactivation and glutathione-dependent cytoprotection in phenytoin teratogenicity: modulation by eicosatetraynoic acid and buthionine sulfoximine in murine embryo culture.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Cyclooxygenase Inhibitors; Disulfides; Drug Interactions; Embryo, Mammalian; Female; Glutathione; Male; Methionine Sulfoximine; Mice; Peroxidases; Phenytoin; Rats; Sulfhydryl Compounds; Teratogens | 1994 |
Effect of glutathione levels on aflatoxin B1-DNA binding in livers and kidneys of male rats and hamsters pretreated with buthionine sulfoximine and dimethylmaleate.
Topics: Aflatoxin B1; Animals; Antimetabolites, Antineoplastic; Biotransformation; Buthionine Sulfoximine; Cricetinae; DNA; DNA Adducts; Glutathione; Glutathione Transferase; Kidney; Liver; Male; Maleates; Mesocricetus; Methionine Sulfoximine; Rats; Rats, Inbred F344; Time Factors | 1994 |
Modifications of cellular thiols during growth and squamous differentiation of cultured human bronchial epithelial cells.
Topics: Antimetabolites; Bronchi; Buthionine Sulfoximine; Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Cysteine; Cystine; Epithelial Cells; Epithelium; Glutathione; Humans; Maleates; Methionine Sulfoximine; Oxidation-Reduction; Serum Albumin, Bovine; Sulfhydryl Compounds; Transforming Growth Factor beta | 1994 |
Reactive naphthalene metabolite binding to hemoglobin and albumin.
Topics: Animals; Buthionine Sulfoximine; Electrophoresis, Polyacrylamide Gel; Glutathione; Hemoglobins; Male; Maleates; Methionine Sulfoximine; Mice; Naphthalenes; Protein Binding; Serum Albumin; Sulfhydryl Compounds | 1994 |
Effect of glutathione depletion on formation of paramagnetic chromium in Chinese hamster V-79 cells.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Chromates; Chromium; Cricetinae; Cricetulus; Electron Spin Resonance Spectroscopy; Glutathione; Glutathione Reductase; Maleates; Methionine Sulfoximine; Sodium Compounds | 1994 |
Effect of depletion of glutathione by buthionine sulfoximine on lipid peroxidation in rats acutely treated with ethanol.
Topics: Animals; Brain; Buthionine Sulfoximine; Erythrocytes; Ethanol; Glutathione; Lipid Peroxidation; Liver; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells.
Topics: Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Buthionine Sulfoximine; Cell Survival; Ethacrynic Acid; Glutathione; Glutathione Transferase; Humans; Methionine Sulfoximine; Tumor Cells, Cultured | 1994 |
Responses of bovine lymphocytes to heat shock as modified by breed and antioxidant status.
Topics: Animals; Antimetabolites; Antioxidants; Breeding; Buthionine Sulfoximine; Cattle; Cell Survival; Cells, Cultured; Female; Glutathione; Heat-Shock Proteins; Hot Temperature; Lymphocyte Activation; Lymphocytes; Methionine Sulfoximine; Thioredoxins | 1994 |
Exogenous glutathione attenuates the antiproliferative effect of buthionine sulfoximine.
Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Carcinoma; Cell Division; Cystine; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Tumor Cells, Cultured | 1994 |
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary (CHO) cell variants--II. Relationships between non-protein sulfhydryl levels and the induction/stability of the oxidant-resistant phenotype.
Topics: Animals; Buthionine Sulfoximine; Cell Division; CHO Cells; Cricetinae; Cricetulus; Drug Resistance; Hydrogen Peroxide; Methionine Sulfoximine; Phenotype; Sulfhydryl Compounds | 1994 |
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Topics: Buthionine Sulfoximine; Colonic Neoplasms; Cysteine; Cytochrome P-450 Enzyme System; DNA, Neoplasm; Drug Interactions; Drug Resistance; Glutathione; Humans; Methionine Sulfoximine; Mitomycin; Mitomycins; Oxidation-Reduction; Sulfhydryl Compounds; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1994 |
Selective in vivo accumulation of N-acetyl-4-S-cysteaminylphenol in B16F10 murine melanoma and enhancement of its in vitro and in vivo antimelanoma effect by combination of buthionine sulfoximine.
Topics: Animals; Autoradiography; Buthionine Sulfoximine; Cysteamine; Dose-Response Relationship, Drug; Drug Synergism; Female; Glutathione; Lung Neoplasms; Melanoma, Experimental; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Phenols | 1994 |
In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects.
Topics: Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Antibody Formation; Antimetabolites; Buthionine Sulfoximine; Dinoprostone; Glutathione; Humans; Interleukin-1; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Methionine Sulfoximine | 1994 |
Buthionine sulfoximine protects the viability of adult rat Leydig cells exposed to ethane dimethanesulfonate.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Leydig Cells; Male; Mesylates; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley | 1994 |
Mechanism of methylmercury efflux from cultured astrocytes.
Topics: Animals; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Cysteine; Glutathione; Methionine Sulfoximine; Methylmercury Compounds; Probenecid; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines | 1994 |
Synthesis and transport of glutathione by cultured human retinal pigment epithelial cells.
Topics: Adult; Amino Acids; Antimetabolites; Biological Transport; Buthionine Sulfoximine; Cells, Cultured; Chromatography, High Pressure Liquid; Glutathione; Humans; Methionine Sulfoximine; Pigment Epithelium of Eye | 1994 |
Enhanced radiation-sensitivity by preincubation with nitroimidazoles: effect of glutathione depletion.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Etanidazole; Glutathione; Methionine Sulfoximine; Radiation Tolerance; Radiation-Sensitizing Agents | 1994 |
The toxic effects, GSH depletion and radiosensitivity by BSO on retinoblastoma.
Topics: Animals; Buthionine Sulfoximine; Eye Neoplasms; Glutathione; Humans; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Radiation-Sensitizing Agents; Retinoblastoma; Tumor Cells, Cultured | 1994 |
Selective toxicity of buthionine sulfoximine (BSO) to melanoma cells in vitro and in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Buthionine Sulfoximine; Cell Line; Cell Survival; Glutathione; Melanoma, Experimental; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Organ Size | 1994 |
Prostaglandin E2 synthesis after oxidant stress is dependent on cell glutathione content.
Topics: 3T3 Cells; Animals; Antimetabolites; Arachidonic Acid; Buthionine Sulfoximine; Carmustine; Chromatography, High Pressure Liquid; Dinitrochlorobenzene; Dinoprostone; Glutathione; Hydrogen Peroxide; Kinetics; Methionine Sulfoximine; Mice; Proteins | 1994 |
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Death; Cell Line; Glutathione; Hydroxyl Radical; Iron; Lipid Peroxidation; Methionine Sulfoximine; Neurons; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saccharomyces cerevisiae; Superoxide Dismutase | 1993 |
Role of apical and basolateral secretion in turnover of glutathione in LLC-PK1 cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Membrane; Cell Membrane Permeability; Glutathione; Half-Life; Intercellular Junctions; Kidney; Kinetics; Methionine Sulfoximine; Sulfur Radioisotopes; Swine | 1993 |
The interaction of auranofin and buthionine sulfoximine blocks activation of human peripheral T lymphocytes.
Topics: Auranofin; Buthionine Sulfoximine; Cell Division; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Humans; Interleukin-2; Lymphocyte Activation; Methionine Sulfoximine; Phytohemagglutinins; Receptors, Interleukin-2; T-Lymphocytes | 1993 |
Effect of buthionine sulfoximine on PtII and PtIV drug accumulation and the formation of glutathione conjugates in human ovarian-carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Buthionine Sulfoximine; Carboplatin; Chromatography, High Pressure Liquid; Cisplatin; Culture Media; Drug Resistance; Female; Glutathione; Humans; Kinetics; Methionine Sulfoximine; Organoplatinum Compounds; Ovarian Neoplasms; Tumor Cells, Cultured | 1993 |
Inhibition of glutathione synthesis increases the toxicity of oxidized low-density lipoprotein to human monocytes and macrophages.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Line; Cell Survival; Glutathione; Humans; Kinetics; Lipid Peroxidation; Lipoproteins, LDL; Macrophages; Methionine Sulfoximine; Monocytes | 1993 |
Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia.
Topics: Buthionine Sulfoximine; Carmustine; Cell Cycle; Cell Division; Cell Line; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Drug; Glutathione; Glutathione Reductase; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methionine Sulfoximine; Tumor Cells, Cultured | 1993 |
Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors.
Topics: Amino Acids; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Glutathione; Humans; Methionine Sulfoximine; Middle Aged; Oxidation-Reduction; Peroxides; Pigment Epithelium of Eye; tert-Butylhydroperoxide | 1993 |
In vivo therapeutic potential of combination thiol depletion and alkylating chemotherapy.
Topics: Alkylating Agents; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Cells; Buthionine Sulfoximine; Cell Survival; Chromatography, High Pressure Liquid; Colony-Forming Units Assay; Drug Resistance; Female; Glutathione; Hematopoietic Stem Cells; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Sarcoma, Experimental | 1993 |
Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.
Topics: Buthionine Sulfoximine; Carcinoma, Hepatocellular; Chloramphenicol O-Acetyltransferase; Diamide; Electron Spin Resonance Spectroscopy; Enzyme Induction; Gene Expression Regulation, Enzymologic; Genes, fos; Genes, jun; Glutathione; Glutathione Transferase; Humans; Methionine Sulfoximine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tumor Cells, Cultured | 1994 |
Differential cytotoxicity of buthionine sulfoximine to "normal" and transformed human lung fibroblast cells.
Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Division; Cell Line; Cell Line, Transformed; Cell Survival; Diamide; Ethylmaleimide; Fibroblasts; Glutathione; Humans; Lung; Methionine Sulfoximine | 1993 |
Free radical scavenger depletion in post-ischemic reperfusion brain damage.
Topics: Animals; Brain; Buthionine Sulfoximine; Ditiocarb; Free Radical Scavengers; Free Radicals; Glutathione; Ischemic Attack, Transient; Kinetics; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 1993 |
Comparative cytotoxicity of angiotensin-converting enzyme inhibitors in cultured rat hepatocytes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Glutathione; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred F344 | 1993 |
Characterization of resistance mechanisms to cis-diamminedichloroplatinum(II) in three sublines of the CC531 colon adenocarcinoma cell line in vitro.
Topics: Adenocarcinoma; Animals; Buthionine Sulfoximine; Cisplatin; Colonic Neoplasms; DNA, Neoplasm; Drug Resistance; Glutathione; Methionine Sulfoximine; Methylazoxymethanol Acetate; Rats; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1994 |
Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TGF-beta 1.
Topics: Analysis of Variance; Animals; Buthionine Sulfoximine; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Hydrogen Peroxide; Kinetics; Maleates; Methionine Sulfoximine; Pulmonary Artery; Time Factors; Transforming Growth Factor beta | 1993 |
Early epithelial lesions in cataracts of GSH-depleted mouse pups.
Topics: Animals; Buthionine Sulfoximine; Cataract; Epithelium; Glutathione; Lens, Crystalline; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Microscopy, Electron; Time Factors | 1993 |
Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time.
Topics: Animals; Antimetabolites; Benzopyrans; Buthionine Sulfoximine; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Cytochrome P-450 Enzyme Inhibitors; Glutathione; Insecticides; Juvenile Hormones; Liver; Male; Methionine Sulfoximine; Plants; Rats; Time Factors; Triazoles | 1994 |
Overcoming tumor necrosis factor-alpha resistance of human renal and ovarian carcinoma cells by combination treatment with buthionine sulfoximine and tumor necrosis factor-alpha. Role of tumor necrosis factor-alpha mRNA down-regulation in tumor cell sensi
Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Blotting, Northern; Buthionine Sulfoximine; Carcinoma, Renal Cell; Down-Regulation; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Kidney Neoplasms; Methionine Sulfoximine; Ovarian Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Effect of cigarette smoke and its condensates on alveolar epithelial cell injury in vitro.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Adhesion; Cell Line; Epithelium; Glutathione; Humans; Hydrogen Peroxide; Male; Methionine Sulfoximine; Nicotiana; Plants, Toxic; Pulmonary Alveoli; Rats; Rats, Wistar; Smoke; Thymidine | 1994 |
Interactions of nitroglycerin and sulfhydryl-donating compounds in coronary microvessels.
Topics: Animals; Blood Vessels; Buffers; Buthionine Sulfoximine; Coronary Circulation; Cysteine; Dogs; Drug Interactions; Female; Glutathione; Male; Methionine Sulfoximine; Microcirculation; Nitric Oxide; Nitroglycerin; Oxygen; Sulfhydryl Compounds; Vasodilation | 1994 |
Lipid hydroperoxide induced mitochondrial dysfunction following acute ethanol intoxication in rats. The critical role for mitochondrial reduced glutathione.
Topics: Alcoholic Intoxication; Animals; Buthionine Sulfoximine; Female; Glutathione; Intracellular Membranes; Linoleic Acids; Lipid Peroxides; Membrane Potentials; Methionine Sulfoximine; Mitochondria, Liver; Rats; Rats, Wistar | 1994 |
Mitomycin C sensitivity in human bladder cancer cells: possible role of glutathione and glutathione transferase in resistance.
Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Ethacrynic Acid; Glutathione; Glutathione Transferase; Humans; Isoenzymes; Kinetics; Methionine Sulfoximine; Mitomycin; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
S-thiolation and irreversible oxidation of sulfhydryls on carbonic anhydrase III during oxidative stress: a method for studying protein modification in intact cells and tissues.
Topics: Animals; Antibodies; Buthionine Sulfoximine; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cells, Cultured; Female; Isoelectric Focusing; Isoenzymes; Liver; Male; Methionine Sulfoximine; Muscles; Myocardium; Oxidation-Reduction; Rabbits; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Vitamin K | 1994 |
Nephrotoxicity and covalent binding of 1,1-dichloroethylene in buthionine sulphoximine-treated mice.
Topics: Animals; Autoradiography; Binding Sites; Buthionine Sulfoximine; Dichloroethylenes; Female; Kidney Diseases; Kidney Tubules, Proximal; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Nasal Mucosa | 1993 |
Glutathione as a cellular defence against arsenite toxicity in cultured Chinese hamster ovary cells.
Topics: Animals; Antimetabolites; Arsenic; Arsenites; Buthionine Sulfoximine; Cell Survival; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; Glutathione; Methionine Sulfoximine; Ultraviolet Rays | 1993 |
Posttranscriptional down-regulation of ras oncogene expression by inhibitors of cellular glutathione.
Topics: 3T3 Cells; Animals; Blotting, Northern; Buthionine Sulfoximine; Cell Cycle; Cycloheximide; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, ras; Glutathione; Humans; Methionine Sulfoximine; Mice; Oncogene Protein p21(ras); Proto-Oncogene Mas; RNA Processing, Post-Transcriptional; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Thiol-modulating agents increase manganese superoxide dismutase activity in human lung fibroblasts.
Topics: Buthionine Sulfoximine; Cell Line; Diamide; Ethylmaleimide; Glutathione; Humans; Lung; Manganese; Methionine Sulfoximine; Sulfhydryl Reagents; Superoxide Dismutase | 1993 |
Activation of heat shock transcription factors by delta 12-prostaglandin J2 and its inhibition by intracellular glutathione.
Topics: Animals; Base Sequence; Buthionine Sulfoximine; Cell Line; DNA; DNA-Binding Proteins; DNA, Single-Stranded; Endothelium, Vascular; Glutathione; Heat Shock Transcription Factors; Humans; Methionine Sulfoximine; Molecular Sequence Data; Prostaglandin D2; Protein Biosynthesis; Sulfhydryl Compounds; Swine; Transcription Factors | 1993 |
Modulation of aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci by pretreatment of rats with phenobarbital and buthionine sulfoximine.
Topics: Aflatoxin B1; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; DNA; Drug Interactions; Enzyme Induction; Glutathione Transferase; Liver; Male; Methionine Sulfoximine; Phenobarbital; Rats; Rats, Inbred F344 | 1993 |
Factors affecting zero background frequency of sister-chromatid exchange in mosquito cells.
Topics: Aedes; Animals; Bromodeoxyuridine; Buthionine Sulfoximine; Cells, Cultured; CHO Cells; Clone Cells; Cricetinae; Dose-Response Relationship, Drug; Drosophila melanogaster; Glutathione; Methionine Sulfoximine; Mitosis; Mutagenicity Tests; Mutagens; Sister Chromatid Exchange | 1993 |
Glutathione metabolism in skeletal muscle derived cells of the L6 line.
Topics: Activins; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Line; Energy Metabolism; Glutathione; Glutathione Transferase; Inhibins; Methionine Sulfoximine; Muscles; Peroxides; Rats; tert-Butylhydroperoxide | 1993 |
Simultaneous measurements of glutathione and activated sulphate (PAPS) synthesis rates and the effects of selective inhibition of glutathione conjugation or sulphation of acetaminophen.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Cells, Cultured; Female; Glutathione; Liver; Methionine Sulfoximine; Nitrophenols; Phosphoadenosine Phosphosulfate; Rats; Rats, Wistar; Sulfates; Sulfotransferases | 1993 |
Enhancement of antitumor activity of cisplatin on human gastric cancer cells in vitro and in vivo by buthionine sulfoximine.
Topics: Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Glutathione; Humans; Male; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Nude; Stomach Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured | 1993 |
Glutathione peroxidase protects cultured mammalian cells from the toxicity of adriamycin and paraquat.
Topics: Animals; Buthionine Sulfoximine; Catalase; Cells, Cultured; Doxorubicin; Glutathione Peroxidase; In Vitro Techniques; Mammals; Methionine Sulfoximine; Paraquat; Superoxide Dismutase; Transfection | 1993 |
Effect of thiol compounds on in vitro development and intracellular glutathione content of bovine embryos.
Topics: Animals; Blastocyst; Buthionine Sulfoximine; Cattle; Culture Techniques; Cysteamine; Embryonic and Fetal Development; Glutathione; Mercaptoethanol; Methionine Sulfoximine; Sulfhydryl Compounds | 1993 |
Glutathione metabolism in primary astrocyte cultures: flow cytometric evidence of heterogeneous distribution of GSH content.
Topics: Animals; Animals, Newborn; Antimetabolites; Astrocytes; Brain Chemistry; Buthionine Sulfoximine; Cell Cycle; Cells, Cultured; Cerebral Cortex; Cytosol; DNA; Flow Cytometry; Glutathione; Half-Life; Hydrogen-Ion Concentration; Methionine Sulfoximine; Nerve Tissue Proteins; Rats; Rats, Wistar | 1993 |
Modulation of sensitivity of human ovarian cancer cells to cis-diamminedichloroplatinum(II) by 12-O-tetradecanoylphorbol-13-acetate and D,L-buthionine-S,R-sulphoximine.
Topics: Buthionine Sulfoximine; Cell Division; Cisplatin; Cystadenocarcinoma; Drug Resistance; Female; Humans; Methionine Sulfoximine; Ovarian Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Toxic and protective effects of L-dopa on mesencephalic cell cultures.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Dopamine; Glutathione; Levodopa; Mesencephalon; Methionine Sulfoximine; Neurons | 1993 |
Synthesis of hsp-70 is enhanced in glutathione-depleted Hep G2 cells.
Topics: Buthionine Sulfoximine; Carmustine; Cells, Cultured; Dimethyl Sulfoxide; Glutathione; Heat-Shock Proteins; Hot Temperature; Humans; Methionine Sulfoximine; Oxidation-Reduction; RNA, Messenger | 1993 |
Inactivation of a redox-sensitive protein phosphatase during the early events of tumor necrosis factor/interleukin-1 signal transduction.
Topics: Amino Acid Sequence; Arsenic; Arsenites; Buthionine Sulfoximine; Cells, Cultured; Cytosol; Ethers, Cyclic; Fibroblasts; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Humans; Hydrogen Peroxide; Interleukin-1; Male; Methionine Sulfoximine; Molecular Sequence Data; Okadaic Acid; Oxidation-Reduction; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 1993 |
Modulation of silica-induced lung injury by reducing lung non-protein sulfhydryls with buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Collagen; Female; Lung; Macrophages, Alveolar; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Neutrophils; Pulmonary Fibrosis; Silicon Dioxide; Sulfhydryl Compounds | 1993 |
Acridine orange-mediated photodamage to cultured cells.
Topics: Acridine Orange; Amitrole; Animals; Azides; Buthionine Sulfoximine; Cathepsin L; Cathepsins; Cell Death; Cysteine Endopeptidases; Cytosol; Deferoxamine; Endopeptidases; Glutathione; Histiocytoma, Benign Fibrous; L-Lactate Dehydrogenase; Light; Lysosomes; Methionine Sulfoximine; Mice; Oxygen; Partial Pressure; Photosensitizing Agents; Radiation-Sensitizing Agents; Sodium Azide; Tumor Cells, Cultured | 1993 |
Mechanism by which ethane dimethanesulfonate kills adult rat Leydig cells: involvement of intracellular glutathione.
Topics: Alkylation; Androgens; Animals; Buthionine Sulfoximine; Carbon Radioisotopes; Cells, Cultured; Cycloheximide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Glutathione; Leydig Cells; Male; Mesylates; Methionine Sulfoximine; Protein Biosynthesis; Rats; Rats, Sprague-Dawley | 1993 |
Effect of stress, adrenalectomy and changes in glutathione metabolism on rat kidney metallothionein content: comparison with liver metallothionein.
Topics: Adrenal Glands; Adrenalectomy; Animals; Buthionine Sulfoximine; Corticosterone; Glutathione; Isoxazoles; Kidney; Liver; Male; Metallothionein; Methionine Sulfoximine; Organ Specificity; Rats; Rats, Sprague-Dawley; Restraint, Physical; Starvation; Stress, Physiological | 1993 |
Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties.
Topics: Animals; Aorta; Buthionine Sulfoximine; Cysteine; Female; Glutathione; Intracellular Membranes; Methionine Sulfoximine; Nitroglycerin; Rats; Rats, Wistar; Sulfhydryl Compounds; Time Factors; Vena Cava, Superior | 1993 |
Establishment of L1210 leukemia cells resistant to the distamycin-A derivative (FCE 24517): characterization and cross-resistance studies.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Cycle; Cell Separation; Distamycins; Drug Resistance; Female; Glutathione; Leukemia L1210; Methionine Sulfoximine; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Nitrogen Mustard Compounds; Tumor Cells, Cultured | 1993 |
Mechanism(s) regulating inhibition of thymidylate synthase and growth by gamma-L-glutaminyl-4-hydroxy-3-iodobenzene, a novel melanin precursor, in melanogenic melanoma cells.
Topics: Animals; Biotransformation; Buthionine Sulfoximine; Cell Division; Glutamine; Glutathione; GTP Phosphohydrolases; Humans; Melanins; Melanoma; Methionine Sulfoximine; Mice; Monophenol Monooxygenase; Oxidation-Reduction; Phenols; Protein Precursors; Tetrazolium Salts; Thiazoles; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Protective elevations of glutathione and metallothionein in cadmium-exposed mesangial cells.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cadmium; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Glomerular Mesangium; Glutathione; Male; Metallothionein; Methionine Sulfoximine; Rats; Rats, Wistar; Thymidine; Tritium; Zinc | 1993 |
Multidrug resistance is a component of V79 cell resistance to the alkylating agent adozelesin.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Benzofurans; Buthionine Sulfoximine; Cell Line; Cricetinae; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA; Drug Resistance; Duocarmycins; Indoles; Methionine Sulfoximine; Verapamil | 1993 |
Glutathione depletion induces heme oxygenase-1 (HSP32) mRNA and protein in rat brain.
Topics: Animals; Base Sequence; Blotting, Northern; Brain; Buthionine Sulfoximine; Glutathione; Heme Oxygenase (Decyclizing); Male; Maleates; Methionine Sulfoximine; Molecular Sequence Data; Polymerase Chain Reaction; Rats; RNA, Messenger | 1993 |
Glutathione depletion increases the cytotoxicity of melphalan to PC-3, an androgen-insensitive prostate cancer cell line.
Topics: Buthionine Sulfoximine; Cell Survival; Glutathione; Humans; Male; Melphalan; Methionine Sulfoximine; Prostatic Neoplasms; Tumor Cells, Cultured | 1993 |
Lethal damage to endothelial cells by oxidized low density lipoprotein: role of selenoperoxidases in cytoprotection against lipid hydroperoxide- and iron-mediated reactions.
Topics: Animals; Antioxidants; Aorta, Thoracic; Azoles; Buthionine Sulfoximine; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Glutathione; Glutathione Peroxidase; Iron; Isoindoles; Lipid Peroxides; Lipoproteins, LDL; Methionine Sulfoximine; Organoselenium Compounds; Oxidation-Reduction; Peroxides; Phenols; Photochemistry; Selenium; tert-Butylhydroperoxide | 1993 |
Role of glutathione for cisplatin nephrotoxicity in young and adult rats.
Topics: Acetylcysteine; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cisplatin; Drug Interactions; Female; Glutathione; Kidney; Methionine Sulfoximine; Rats; Rats, Wistar | 1993 |
Role of antioxidant enzymes in the induction of increased experimental metastasis by hydroxyurea.
Topics: Animals; Buthionine Sulfoximine; Catalase; Female; Gene Expression; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hydrogen Peroxide; Hydroxyurea; Melanoma, Experimental; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oxidation-Reduction; RNA, Messenger; RNA, Neoplasm | 1993 |
Toxicity of paracetamol in cultured chick hepatocytes treated with methotrexate.
Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Buthionine Sulfoximine; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Glutathione; Liver; Methionine Sulfoximine; Methotrexate | 1993 |
Antiproliferative and chemomodulatory effects of interferon-gamma on doxorubicin-sensitive and -resistant tumor cell lines.
Topics: Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Division; Doxorubicin; Drug Resistance; Friend murine leukemia virus; Glutathione; Humans; Interferon-gamma; Leukemia, Erythroblastic, Acute; Melanoma, Experimental; Methionine Sulfoximine; Mice; Tumor Cells, Cultured | 1993 |
Modulation of acrylonitrile-induced embryotoxicity in vitro by glutathione depletion.
Topics: Abnormalities, Drug-Induced; Acrylonitrile; Animals; Antimetabolites; Buthionine Sulfoximine; Drug Synergism; Embryo, Mammalian; Female; Glutathione; In Vitro Techniques; Male; Methionine Sulfoximine; Microscopy, Electron, Scanning; Proteins; Rats; Rats, Sprague-Dawley; Yolk Sac | 1993 |
Inactivation of enzymes of the glutathione antioxidant system by treatment of cultured human keratinocytes with peroxides.
Topics: Antimetabolites; Benzene Derivatives; Buthionine Sulfoximine; Calcium; Catalase; Cells, Cultured; Culture Media; Enzyme Activation; Ferric Compounds; Ferrous Compounds; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Reductase; Humans; Hydrogen Peroxide; Keratinocytes; Methionine Sulfoximine; Oxidants; Peroxides; tert-Butylhydroperoxide; Time Factors | 1993 |
Variable glutathione levels and expression of antioxidant enzymes in human endothelial cells.
Topics: Blotting, Northern; Buthionine Sulfoximine; Catalase; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Humans; Hypoxanthine; Hypoxanthines; L-Lactate Dehydrogenase; Maleates; Methionine Sulfoximine; Oxygen; RNA, Messenger; Superoxide Dismutase; Umbilical Veins; Xanthine Oxidase | 1993 |
Depletion of tumour glutathione in vivo by buthionine sulphoximine: modulation by the rate of cellular proliferation and inhibition of cancer growth.
Topics: Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Carcinoma, Ehrlich Tumor; Cell Division; Dose-Response Relationship, Drug; Glutathione; Male; Methionine Sulfoximine; Mice | 1993 |
Role of glutathione in the maturation and fertilization of pig oocytes in vitro.
Topics: Animals; Buthionine Sulfoximine; Cytoplasm; Female; Fertilization in Vitro; Glutathione; In Vitro Techniques; Male; Methionine Sulfoximine; Oocytes; Sperm-Ovum Interactions; Swine | 1993 |
Characteristics of the glutathione/glutathione-S-transferase detoxification system in melphalan resistant human prostate cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Buthionine Sulfoximine; Cell Division; Dose-Response Relationship, Drug; Drug Resistance; Glutathione; Glutathione Transferase; Humans; Male; Melphalan; Methionine Sulfoximine; Prostatic Neoplasms; Tumor Cells, Cultured | 1993 |
The effect of glutathione depletion on methyl mercury-induced microtubule disassembly in cultured embryonal carcinoma cells.
Topics: Animals; Buthionine Sulfoximine; Embryo, Mammalian; Glutathione; Methionine Sulfoximine; Methylmercury Compounds; Mice; Microscopy, Fluorescence; Microtubules; Sulfhydryl Compounds; Tumor Cells, Cultured | 1993 |
Glutathione oxidation and embryotoxicity elicited by diamide in the developing rat conceptus in vitro.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Carmustine; Chromatography, High Pressure Liquid; Diamide; Embryo, Mammalian; Female; Glutaredoxins; Glutathione; Glutathione Disulfide; In Vitro Techniques; Methionine Sulfoximine; Oxidation-Reduction; Oxidoreductases; Protein Disulfide Reductase (Glutathione); Rats; Rats, Sprague-Dawley | 1993 |
Effect of oxidant exposure on thiol status in the intestinal mucosa.
Topics: Animals; Antimetabolites; Biological Transport; Buthionine Sulfoximine; Epithelium; Glutathione; Glutathione Disulfide; Intestinal Mucosa; Methionine Sulfoximine; Oxidants; Oxidation-Reduction; Rats; Rats, Wistar; Reactive Oxygen Species; Sulfhydryl Compounds | 1993 |
Effect of acute and chronic glutathione depletion on renal function in the rat.
Topics: Ammonium Chloride; Animals; Antimetabolites; Buthionine Sulfoximine; Creatinine; Electrolytes; Enzyme Inhibitors; Glutathione; Hydrogen-Ion Concentration; Kidney; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley | 1995 |
Oxidized glutathione decreases luminal Ca2+ content of the endothelial cell ins(1,4,5)P3-sensitive Ca2+ store.
Topics: Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Calcium; Carmustine; Cattle; Cells, Cultured; Cytosol; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Hydroquinones; Inositol 1,4,5-Trisphosphate; Methionine Sulfoximine; Oxidants; Peroxides; Pulmonary Artery; Signal Transduction; tert-Butylhydroperoxide | 1995 |
Purification and characterization of gamma-glutamylcysteine synthetase from Ascaris suum.
Topics: Animals; Ascaris suum; Buthionine Sulfoximine; Chromatography, Gel; Cystamine; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Helminth Proteins; Kidney; Kinetics; Methionine Sulfoximine; Molecular Weight; Rats; Species Specificity; Substrate Specificity | 1995 |
Formation of paramagnetic chromium in liver of mice treated with dichromate (VI).
Topics: Animals; Buthionine Sulfoximine; Chromium; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Glutathione; Kinetics; Liver; Male; Methionine Sulfoximine; Mice; Ornithine Carbamoyltransferase; Phenobarbital; Potassium Dichromate; Spectrum Analysis | 1995 |
Enhancement of the depigmenting effect of hydroquinone by cystamine and buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cystamine; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Guinea Pigs; Hair Color; Hydroquinones; Melanoma; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Skin Pigmentation; Tumor Cells, Cultured | 1995 |
Cytogenetic and pathogenic effects of long and short amosite asbestos.
Topics: Animals; Asbestos, Amosite; Buthionine Sulfoximine; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; Drug Synergism; Glutathione; Methionine Sulfoximine; Mineral Fibers; Mitotic Index | 1995 |
Correlation between glutathione and stimulation of the pentose phosphate cycle in situ in Chinese hamster ovary cells exposed to hydrogen peroxide.
Topics: Amitrole; Animals; Buthionine Sulfoximine; Carmustine; CHO Cells; Cricetinae; Enzyme Inhibitors; Glucosephosphate Dehydrogenase; Glutamate-Cysteine Ligase; Glutathione; Hydrogen Peroxide; Kinetics; Methionine Sulfoximine; Oxidation-Reduction; Paraquat; Pentose Phosphate Pathway | 1996 |
Combined effects of buthionine sulfoximine and cepharanthine on cytotoxic activity of doxorubicin to multidrug-resistant cells.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Buthionine Sulfoximine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Female; Glutathione; Leukemia P388; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1995 |
Atherogenic levels of low-density lipoprotein increase hydrogen peroxide generation in cultured human endothelial cells: possible mechanism of heightened endocytosis.
Topics: Antimetabolites; Arteriosclerosis; Buthionine Sulfoximine; Cells, Cultured; Cytoskeleton; Endocytosis; Endothelium, Vascular; Humans; Hydrogen Peroxide; Lipoproteins, LDL; Methionine Sulfoximine; Umbilical Veins | 1996 |
Reversion in Chinese hamster lines amplified at the AMPD2 locus: spontaneous and benzamide-stimulated gradual loss of amplified alleles of marker genes.
Topics: Alleles; AMP Deaminase; Animals; Benzamides; Buthionine Sulfoximine; Cell Line; Cricetinae; Enzyme Inhibitors; Fibroblasts; Gene Amplification; Glutamate-Cysteine Ligase; Glutathione Transferase; In Situ Hybridization; Methionine Sulfoximine; Poly(ADP-ribose) Polymerase Inhibitors | 1996 |
Buthionine sulfoximine enhances glutathione-but attenuates glutamate-stimulated cell proliferation.
Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Carcinoma; Cell Division; Culture Media; Enzyme Inhibitors; Glutamic Acid; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Tumor Cells, Cultured | 1995 |
Cross-resistance and collateral sensitivity to natural product drugs in cisplatin-sensitive and -resistant rat lymphoma and human ovarian carcinoma cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Survival; Cisplatin; Colchicine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Lymphoma; Methionine Sulfoximine; Mitosis; Ovarian Neoplasms; Paclitaxel; Rats; Tumor Cells, Cultured; Verapamil; Vinca Alkaloids | 1996 |
Deoxyribonucleoside triphosphate pools and growth of glutathione-depleted 3T6 mouse fibroblasts.
Topics: Amino Acid Sequence; Animals; Binding Sites; Buthionine Sulfoximine; Cell Division; Cell Line; Deoxyribonucleotides; DNA; Electron Transport; Enzyme Inhibitors; Fibroblasts; Glutamate-Cysteine Ligase; Glutaredoxins; Glutathione; Methionine Sulfoximine; Mice; Molecular Sequence Data; NADP; Oxidation-Reduction; Oxidoreductases; Proteins; Thioredoxins | 1996 |
Glucose may induce cell death through a free radical-mediated mechanism.
Topics: Animals; Buthionine Sulfoximine; Cell Death; Cell Line; DNA; DNA Damage; Flow Cytometry; Free Radicals; Glucose; Glutathione; Malondialdehyde; Methionine Sulfoximine; Radiation-Protective Agents; Rats; Thyroid Gland | 1996 |
Effect of nonprotein thiols on protein synthesis in isolated rat hepatocytes.
Topics: Amino Acids; Aminooxyacetic Acid; Animals; Antimetabolites; Buthionine Sulfoximine; Carbon Radioisotopes; Cells, Cultured; Cysteine; Kinetics; Liver; Maleates; Methionine; Methionine Sulfoximine; Protein Biosynthesis; Rats; Rats, Wistar; Sulfhydryl Compounds | 1996 |
Impaired pial arteriolar reactivity to hypercapnia during hyperammonemia depends on glutamine synthesis.
Topics: Acetates; Acetic Acid; Ammonia; Animals; Arterioles; Astrocytes; Blood Pressure; Buthionine Sulfoximine; Cerebrovascular Circulation; Enzyme Inhibitors; Glutamine; Hypercapnia; Infusions, Intravenous; Male; Methionine Sulfoximine; Pia Mater; Rats; Rats, Wistar; Reference Values; Regional Blood Flow | 1996 |
Metabolism of compound A by renal cysteine-S-conjugate beta-lyase is not the mechanism of compound A-induced renal injury in the rat.
Topics: Aminooxyacetic Acid; Anesthetics, Inhalation; Animals; Buthionine Sulfoximine; Carbon-Sulfur Lyases; Enzyme Inhibitors; Ethers; Glutathione; Hydrocarbons, Fluorinated; Isoxazoles; Kidney; Kidney Diseases; Lyases; Male; Methionine Sulfoximine; Methyl Ethers; Rats; Rats, Wistar; Sevoflurane | 1996 |
Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease.
Topics: Analysis of Variance; Animals; Azathioprine; Buthionine Sulfoximine; Cells, Cultured; Endothelium; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Hepatic Veno-Occlusive Disease; Immunosuppressive Agents; Inactivation, Metabolic; Liver; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Monocrotaline | 1996 |
Changes in rat liver gene expression induced by thioacetamide: protective role of S-adenosyl-L-methionine by a glutathione-dependent mechanism.
Topics: Actins; Alanine Transaminase; Albumins; Animals; Buthionine Sulfoximine; Enzyme Inhibitors; Gene Expression; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Reductase; Liver; Male; Methionine Sulfoximine; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylmethionine; Thioacetamide | 1996 |
Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Buthionine Sulfoximine; Cataract; Female; Glutathione; Glutathione Disulfide; Lens, Crystalline; Methionine Sulfoximine; Pregnancy; Rats; Rats, Sprague-Dawley; Stereoisomerism; Thioctic Acid; Vitamin E | 1996 |
Suppression of plasma estradiol and progesterone concentrations by buthionine sulfoximine in female rats.
Topics: Alkaline Phosphatase; Animals; Antimetabolites, Antineoplastic; Blood Urea Nitrogen; Buthionine Sulfoximine; Creatine; Creatinine; Erythrocytes; Estradiol; Female; Glutathione; Hematocrit; Hemoglobins; Hormones; Humans; Liver; Methionine Sulfoximine; Ovary; Progesterone; Rats; Rats, Sprague-Dawley | 1996 |
Generation of DNA base modification following treatment of cultured murine keratinocytes with benzoyl peroxide.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Benzoyl Peroxide; Buthionine Sulfoximine; Cell Line; Deoxyguanosine; DNA; DNA Damage; Enzyme Inhibitors; Keratinocytes; Keratolytic Agents; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Phenanthrolines | 1996 |
Neuroprotective effect of insulin-like growth factor I in immortalized hypothalamic cells.
Topics: Animals; Benzoquinones; Buthionine Sulfoximine; Cell Death; Cell Line, Transformed; Ethacrynic Acid; Hypothalamus; Insulin-Like Growth Factor I; Maleates; Methionine Sulfoximine; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Radiation-Protective Agents; Ubiquinone; Vitamin K | 1996 |
Fibre-induced lipid peroxidation leads to DNA adduct formation in Salmonella typhimurium TA104 and rat lung fibroblasts.
Topics: Acetylcysteine; Animals; Antidotes; Asbestos, Crocidolite; Asbestos, Serpentine; Buthionine Sulfoximine; Carcinogens; Deferoxamine; DNA; DNA Adducts; Enzyme Inhibitors; Ferrozine; Fibroblasts; Glass; Glutathione; Lipid Peroxidation; Lung; Malondialdehyde; Methionine Sulfoximine; Mineral Fibers; Rats; Salmonella typhimurium; Thiobarbituric Acid Reactive Substances | 1996 |
Assessment of the role of the glutathione and pentose phosphate pathways in the protection of primary cerebrocortical cultures from oxidative stress.
Topics: Amitrole; Animals; Buthionine Sulfoximine; Carcinogens; Catalase; Cell Death; Cells, Cultured; Cerebral Cortex; Chelating Agents; Deferoxamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glutamate-Cysteine Ligase; Glutathione; Hydrogen Peroxide; Iron; Lactates; Lactic Acid; Methionine Sulfoximine; Neuroglia; Neurons; Neuroprotective Agents; Oxidative Stress; Pentose Phosphate Pathway; Rats; Siderophores; Succimer | 1996 |
Delayed repair: the role of glutathione in a rat incisional wound model.
Topics: Allopurinol; Animals; Buthionine Sulfoximine; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Glutamate-Cysteine Ligase; Glutathione; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Wound Healing; Xanthine Oxidase | 1996 |
Glutathione depletion impairs transcriptional activation of heat shock genes in primary cultures of guinea pig gastric mucosal cells.
Topics: Animals; Base Sequence; Blotting, Western; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; DNA-Binding Proteins; Gastric Mucosa; Glutathione; Guinea Pigs; Heat Shock Transcription Factors; Heat-Shock Proteins; Male; Methionine Sulfoximine; Molecular Sequence Data; RNA, Messenger; Transcription Factors; Transcriptional Activation | 1996 |
Potentiation of enediyne-induced apoptosis and differentiation by Bcl-2.
Topics: Adrenal Gland Neoplasms; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Buthionine Sulfoximine; Cell Differentiation; Cells, Cultured; Cisplatin; Methionine Sulfoximine; Neoplasm Proteins; Oxidation-Reduction; Pheochromocytoma; Prodrugs; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Transfection; Zinostatin | 1996 |
Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Differentiation; Daunorubicin; DNA Damage; DNA Nucleotidylexotransferase; DNA, Neoplasm; Free Radical Scavengers; Humans; Leukemia, Myeloid, Acute; Methionine Sulfoximine; Nucleosomes; Pyrrolidines; Thiocarbamates; Tumor Cells, Cultured; Verapamil | 1996 |
Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Culture Media, Conditioned; Cycloheximide; Cysteine; Cytotoxicity, Immunologic; fas Receptor; Glutathione; Humans; Immunity, Innate; Intracellular Fluid; Killer Cells, Lymphokine-Activated; Leukemia, T-Cell; Lymphocyte Activation; Methionine Sulfoximine; T-Lymphocytes; Tumor Cells, Cultured | 1996 |
Mechanisms of protection by buthionine sulphoximine against gamma-ray-induced micronuclei in polychromatic erythrocytes of mouse bone marrow.
Topics: Animals; Bone Marrow; Buthionine Sulfoximine; Erythrocytes; Gamma Rays; Glutathione; Hydroxyl Radical; Male; Methionine Sulfoximine; Mice; Micronuclei, Chromosome-Defective; Oxygen; Radiation-Protective Agents; Singlet Oxygen | 1996 |
Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells.
Topics: Antineoplastic Agents, Alkylating; Base Sequence; Buthionine Sulfoximine; Carmustine; Cell Survival; DNA; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glioma; Glutamate-Cysteine Ligase; Glutathione; Humans; Kinetics; Methionine Sulfoximine; Molecular Sequence Data | 1996 |
Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages.
Topics: Adolescent; Aged; Aged, 80 and over; Aging; Buthionine Sulfoximine; Catalase; Cell Line; Fetus; Fibroblasts; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Humans; Hydrogen Peroxide; Methionine Sulfoximine; RNA, Messenger; Skin | 1996 |
Pneumotoxicity and hepatotoxicity of styrene and styrene oxide.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Epoxy Compounds; gamma-Glutamyltransferase; Injections, Intraperitoneal; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Liver Diseases; Lung Diseases; Male; Methionine Sulfoximine; Mice; Phenobarbital; Pyridines; Styrene; Styrenes; Trichloroepoxypropane | 1996 |
Gastric injury and protection against alcohol and acid: influence of perturbations in glutathione metabolism.
Topics: Animals; Buthionine Sulfoximine; Ethanol; Female; Gastric Mucosa; Glutathione; Glutathione Peroxidase; Hydrochloric Acid; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Selenium | 1996 |
Diisopropylphosphorofluoridate-induced cholinergic hyperactivity and lipid peroxidation.
Topics: 3,4-Methylenedioxyamphetamine; Acetylcholinesterase; Animals; Buthionine Sulfoximine; Cholinergic Fibers; Cholinesterase Inhibitors; Chromans; Diaphragm; Free Radical Scavengers; Free Radicals; Glutathione; Isoflurophate; Lipid Peroxidation; Male; Methionine Sulfoximine; Muscle Fibers, Skeletal; Necrosis; Piperazines; Rats; Rats, Sprague-Dawley; Thiobarbiturates; Tubocurarine | 1996 |
Determination of L-buthionin (SR)-sulfoximine, gamma-glutamylcysteine synthetase inhibitor in rat plasma with HPLC after prelabeling with dansyl chloride.
Topics: Animals; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Dansyl Compounds; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Hydrogen-Ion Concentration; Methionine Sulfoximine; Microchemistry; Rats; Temperature | 1996 |
Impact of oxidative stress on human cytomegalovirus replication and on cytokine-mediated stimulation of endothelial cells.
Topics: Base Sequence; Buthionine Sulfoximine; Cell Adhesion Molecules; Cells, Cultured; Cytokines; Cytomegalovirus; Cytomegalovirus Infections; Endothelium, Vascular; HLA Antigens; HLA-DR Antigens; Humans; Methionine Sulfoximine; Molecular Sequence Data; Oxidation-Reduction; Oxidative Stress; Stimulation, Chemical; Sulfhydryl Compounds; Virus Replication | 1996 |
Glutathione depletion induces glycogenolysis dependent ascorbate synthesis in isolated murine hepatocytes.
Topics: Acetaminophen; Animals; Ascorbic Acid; Bucladesine; Buthionine Sulfoximine; Cyclic AMP; Diamide; Fructose; Glutathione; Glycogen; Liver; Male; Methionine Sulfoximine; Mice; Sugar Acids; Uridine Diphosphate Glucose; Vitamin K | 1996 |
Pathways of glutathione metabolism and transport in isolated proximal tubular cells from rat kidney.
Topics: Animals; Biological Transport; Buthionine Sulfoximine; Cells, Cultured; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Glutathione Disulfide; Isoxazoles; Kidney Tubules, Proximal; Male; Methionine Sulfoximine; Peroxides; Rats; Rats, Inbred F344; tert-Butylhydroperoxide | 1996 |
Antioxidant survey to assess antagonism to redox stress using a prokaryotic and an eukaryotic system.
Topics: Antioxidants; Buthionine Sulfoximine; Cysteine; Escherichia coli; Eukaryota; Free Radicals; Glutathione; Homocysteine; Methionine Sulfoximine; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Vitamin K; Vitamin K 3 | 1996 |
Effect of acute exercise on glutathione deficient heart.
Topics: Animals; Buthionine Sulfoximine; Fatigue; gamma-Glutamyltransferase; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Heart; Lipid Peroxidation; Male; Methionine Sulfoximine; Mice; Muscle Proteins; Myocardium; Oxidation-Reduction; Oxidative Stress; Physical Exertion; Reactive Oxygen Species | 1996 |
Postischemic injury in isolated rat hearts is not aggravated by prior depletion of myocardial glutathione.
Topics: Adenosine Triphosphate; Animals; Benzene Derivatives; Buthionine Sulfoximine; Glutathione; Male; Methionine Sulfoximine; Myocardial Reperfusion Injury; Myocardium; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species | 1996 |
Glucose, glutathione, and cellular response to spermine oxidation products.
Topics: Acrolein; Aldehydes; Amine Oxidase (Copper-Containing); Animals; Buthionine Sulfoximine; Catalase; Cattle; Cell Survival; CHO Cells; Cricetinae; Glucose; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Pentose Phosphate Pathway; Spermine | 1996 |
Mitochondrial damage: an important feature in a number of inborn errors of metabolism?
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Electron Transport Complex IV; Glutathione; Metabolism, Inborn Errors; Methionine Sulfoximine; Mitochondria; Rats; Rats, Sprague-Dawley | 1996 |
Inhibition of glutathione synthesis of Ascaris suum by buthionine sulfoximine.
Topics: Animals; Antimetabolites; Antinematodal Agents; Ascaris suum; Buthionine Sulfoximine; Genitalia; Glutathione; Kinetics; Methionine Sulfoximine; Muscles; Organ Specificity; Time Factors | 1996 |
BDNF or IGF-I potentiates free radical-mediated injury in cortical cell cultures.
Topics: Animals; Brain-Derived Neurotrophic Factor; Buthionine Sulfoximine; Cell Death; Cells, Cultured; Cerebral Cortex; Drug Synergism; Enzyme Inhibitors; Ferric Compounds; Glutamate-Cysteine Ligase; Insulin-Like Growth Factor I; Methionine Sulfoximine; Mice; Nerve Growth Factors; Nerve Tissue Proteins; Neurons | 1995 |
Thiol-mediated redox regulation of neutrophil apoptosis.
Topics: Antioxidants; Apoptosis; Buthionine Sulfoximine; Diamide; Enzyme Inhibitors; Flow Cytometry; Glutathione; Glutathione Transferase; Humans; Maleates; Methionine Sulfoximine; Neutrophils; Oxidation-Reduction; Protein-Tyrosine Kinases; Sulfhydryl Compounds; Sulfhydryl Reagents | 1996 |
Lack of a role of glutathione in cellular nonenzymatic activation of BMS-181174, a novel analogue of mitomycin C.
Topics: Antineoplastic Agents, Alkylating; Biotransformation; Buthionine Sulfoximine; Cysteine; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Humans; Methionine Sulfoximine; Mitomycin; Mitomycins; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1996 |
[Rhythmic component of twelve hours].
Topics: Adult; Animals; Antimetabolites; Antimetabolites, Antineoplastic; Bone Marrow Cells; Buthionine Sulfoximine; Cell Division; Circadian Rhythm; Colorectal Neoplasms; Depression, Chemical; Female; Fluorouracil; Glutathione; Humans; Kidney; Liver; Male; Methionine Sulfoximine; Mice; Motor Activity; Mouth Mucosa | 1996 |
Role of glutathione redox cycle in TNF-alpha-mediated endothelial cell dysfunction.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Cell Membrane Permeability; Endothelium, Vascular; Glutathione; Lipid Peroxides; Methionine Sulfoximine; Oxidation-Reduction; Swine; Tumor Necrosis Factor-alpha | 1995 |
In vitro activity of titanocenedichloride versus cisplatin in four ovarian carcinoma cell lines evaluated by a microtiter plate ATP bioluminescence assay.
Topics: Adenocarcinoma; Adenosine Triphosphate; Buthionine Sulfoximine; Cell Count; Cell Death; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Female; Humans; Lethal Dose 50; Luminescent Measurements; Methionine Sulfoximine; Organometallic Compounds; Ovarian Neoplasms; Tumor Cells, Cultured | 1995 |
On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein (MRP).
Topics: Antimetabolites, Antineoplastic; ATP-Binding Cassette Transporters; Biological Transport; Buthionine Sulfoximine; Daunorubicin; Fluoresceins; Glutathione; Humans; Methionine Sulfoximine; Multidrug Resistance-Associated Proteins; Probenecid; Tumor Cells, Cultured | 1995 |
Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat.
Topics: Ammonia; Animals; Astrocytes; Body Water; Buthionine Sulfoximine; Capillaries; Cell Nucleus; Cell Size; Endoplasmic Reticulum; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Male; Methionine Sulfoximine; Mitochondria; Rats; Rats, Wistar | 1996 |
Preserved hypocapnic pial arteriolar constriction during hyperammonemia by glutamine synthetase inhibition.
Topics: Acetates; Ammonia; Animals; Arterioles; Buthionine Sulfoximine; Cerebrovascular Circulation; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Hypocapnia; Male; Methionine Sulfoximine; Pia Mater; Rats; Rats, Wistar; Vascular Resistance; Vasoconstriction | 1999 |
Did consumption of flour bleached by the agene process contribute to the incidence of neurological disease?
Topics: Buthionine Sulfoximine; Chlorides; Flour; Food Contamination; Food Handling; Glutamine; Glutathione; Humans; Methionine Sulfoximine; Models, Neurological; Nervous System; Neurodegenerative Diseases; Nitrogen Compounds; Oxidative Stress | 1998 |
Glucocorticoids induce glutamine synthetase in folliculostellate cells of rat pituitary glands in vivo and in vitro.
Topics: Adrenalectomy; Age Factors; Animals; Buthionine Sulfoximine; Cells, Cultured; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Glucocorticoids; Glutamate-Ammonia Ligase; Glutamate-Cysteine Ligase; Hydrocortisone; Immunohistochemistry; Male; Methionine Sulfoximine; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; S100 Proteins | 1999 |
Inhibition of Müller cell glutamine synthetase rapidly impairs the retinal response to light.
Topics: Analysis of Variance; Animals; Buthionine Sulfoximine; Electroretinography; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Immunohistochemistry; Light; Methionine Sulfoximine; Rats; Rats, Wistar; Retina; Time Factors | 2000 |
Association of glutathione with flowering in Arabidopsis thaliana.
Topics: Arabidopsis; Buthionine Sulfoximine; Cyclophosphamide; Glutathione; Glutathione Transferase; Light; Methionine Sulfoximine; Morphogenesis; Mutation; Phenotype | 2001 |
Inhibition of glutamine synthetase in a549 cells during hyperoxia.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Division; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Humans; Hyperoxia; Methionine Sulfoximine; Oxygen; Respiratory Mucosa | 2002 |
Synthesis and bioactivity of new phosphorylated R,R'-substituted sulfoximines.
Topics: Acetylcholinesterase; Animals; Buthionine Sulfoximine; Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Houseflies; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Models, Molecular; Molecular Structure; Organophosphorus Compounds; Phosphorylation; Structure-Activity Relationship | 2005 |
Methionine sulfoximine supplementation enhances productivity in GS-CHOK1SV cell lines through glutathione biosynthesis.
Topics: Animals; Antibodies, Monoclonal; Batch Cell Culture Techniques; Buthionine Sulfoximine; Cell Culture Techniques; CHO Cells; Cricetinae; Cricetulus; Culture Media; Glutamate-Ammonia Ligase; Glutamine; Glutathione; Methionine Sulfoximine; Recombinant Proteins; Transfection | 2017 |
Adsorption of l-buthionine sulfoximine on Bi(III) and Eu(III) co-substituted hydroxyapatite nanocrystals for enhancing radiosensitization effects.
Topics: Adsorption; Buthionine Sulfoximine; Durapatite; Glutathione; Humans; Ions; Methionine Sulfoximine; Nanoparticles; Neoplasms | 2023 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |