Page last updated: 2024-08-22

buthionine sulfoximine and melphalan

buthionine sulfoximine has been researched along with melphalan in 69 studies

Research

Studies (69)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (30.43)	18.7374
1990's	35 (50.72)	18.2507
2000's	9 (13.04)	29.6817
2010's	4 (5.80)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Alvero-Jackson, H; Benathan, M; Frenk, E; Mooy, AM; Scaletta, C	1
Guenthner, TM; Jevtović-Todorović, V	1
Alaoui-Jamali, MA; Batist, G; Centurioni, GM; Lehnert, S; Panasci, L; Schecter, R	1
FitzGerald, GB; Prezioso, JA; Wick, MM	1
Carp, N; Comis, RL; Hamilton, TC; LaCreta, FP; O'Dwyer, PJ; Ozols, RF; Padavic, K; Tew, KD; Young, RC	1
Greig, NH; Rapoport, SI; Smith, QR; Takada, Y; Vistica, DT	1
Awasthi, YC; Gupta, V; Medh, RD	1
Bellamy, WT; Dalton, WS; Gleason, MC; Grogan, TM; Trent, JM	1
Britten, RA; Broughton, C; Browning, PG; Green, JA; Warenius, HM; White, R	1
Frankfurt, OS; Seckinger, D; Sugarbaker, EV	2
Benz, CC; Ford, JM; Hait, WN; Matlin, SA	1
Bigner, DD; Friedman, HS; Griffith, OW; McMahon, DP; Postels, DG; Skapek, SX; VanDellen, AF	1
Hamilton, TC; O'Dwyer, PJ; Ozols, RF; Young, RC	1
Gipp, JJ; McClelland, RA; Mulcahy, RT; Ublacker, GA	1
Barranco, SC; Beasley, EG; Liu, NH; MacLean, KK; Schellenberg, K; Shaeffer, J; Townsend, CM; Weintraub, B	1
Du, DL; Grieshaber, CK; Murphy, MJ; Volpe, DA	1
DeGraff, W; Friedman, N; Mitchell, JB; Russo, A	1
Bigner, DD; Bigner, SH; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Horton, JK; Lilley, E; Rosenberg, MC	1
Ardiet, C; Navarro, C; Sapet, C; Tranchand, B	1
Grieshaber, CK; Liao, JT; Page, JG; Smith, AC; Wientjes, MG	1
Bigner, DD; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Hilton, J; Lippitz, B; Schold, SC	1
Frankfurt, OS	1
Deeg, HJ; Luk, K; Shulman, HM; Shuman, WB; Storb, R	1
Roizin-Towle, L	1
Hamilton, TC; Ozols, RF; Young, RC	1
Edgren, M; Ehrsson, H; Hansson, J; Nilsson, B; Ringborg, U	1
Bigner, DD; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Skapek, SX	1
Dorr, RT	1
Dorr, RT; Liddil, JD; Soble, MJ	1
Cohen, GM; d'Arcy Doherty, M; Jordan, J	1
Carmichael, J; DeGraff, W; Fisher, J; Friedman, N; Mitchell, JB; Phillips, T; Russo, A; Tochner, Z	1
Behrens, BC; Dykes, D; Fine, RL; Hamilton, TC; Louie, KG; Ozols, RF; Plowman, J	1
Ahmad, S; Greene, K; Kramer, RA; Vistica, DT	1
Batist, G; Behrens, BC; Grotzinger, KR; Hamilton, TC; Louie, KG; McKoy, WM; Ozols, RF; Tsuruo, T; Winker, MA; Young, RC	1
Biaglow, JE; Costello, T; Hall, EJ; Roizin-Towle, L; Varnes, ME	1
Green, JA; Hamilton, TC; Ozols, RF; Rogan, AM; Vistica, DT; Young, RC	1
Somfai-Relle, S; Suzukake, K; Vistica, BP; Vistica, DT	1
Brennan, J; Gallo, JM; Halbherr, T; Hamilton, TC; Laub, PB; O'Dwyer, PJ; Ozols, RF	1
Aloui-Jamali, MA; Batist, G; Lehnert, S; Vestergaard, J	1
Beyers, KL; Siemann, DW	1
Alberti, D; Arzoomanian, RZ; Bailey, HH; Mulcahy, RT; Pomplun, M; Spriggs, DR; Tombes, MB; Tutsch, KD; Wilding, G	1
Canada, A; Herman, L; Kidd, K; Robertson, C; Trump, D	1
Mulcahy, RT; Ripple, M; Wilding, G	1
Bookman, MA; Brennan, J; Comis, RL; Gallo, JM; Halbherr, T; Hamilton, TC; Hoffman, J; Kilpatrick, D; LaCreta, FP; O'Dwyer, PJ; Ozols, RF; Young, RC	1
Cook, JA; DeGraff, W; Krishna, MC; Liebmann, J; Mitchell, JB; Pacelli, R; Russo, A; Wink, DA	1
Alberti, D; Arzoomanian, RZ; Bailey, HH; Feierabend, C; Mahvi, D; Mulcahy, RT; Pomplun, M; Ripple, G; Schink, J; Tutsch, KD; Wilding, G	1
Canteras-Jordana, M; Rodriguez-Vicente, J; Vicente-Ortega, V	1
Barnouin, K; Jedlitschky, G; Keppler, D; König, J; Lehmann, WD; Leier, I; Pourtier-Manzanedo, A	1
Anderson, CP; Chan, W; Forman, HJ; Lui, RM; Park, CK; Reynolds, CP; Tian, L; Tsai, J	1
Calvert, P; Hamilton, TC; O'Dwyer, PJ; Yao, KS	1
Bailey, HH	1
al-Bassam, M; Buzaid, AC; Dasgupta, C; Fruehauf, JP; Kyshtoobayeva, A; Milovanovic, T; Parker, RJ; Zonis, S	1
Mulder, GJ; Schutrups, J; Vahrmeijer, AL; van de Velde, CJ; van Dierendonck, JH	2
Bloomer, WD; Ji, M; Khan, SH; Papadopoulou, MV	1
Anderson, CP; Keshelava, N; Meek, WH; Reynolds, CP; Satake, N	1
Aller, P; de Blas, E; Fernández, C; Sancho, P; Troyano, A	1
Anderson, CP; Bailey, HH; Keshelava, N; Monforte-Munoz, HL; Reynolds, CP; Satake, N; Seeger, RC	1
Anderson, CP; Reynolds, CP	1
Alfaro, PA; Goto, H; Kohn, DB; Pepper, KA; Petersen, D; Reynolds, CP; Yang, B	1
Abdel-Wahab, O; Cheng, TY; Friedman, HS; Grubbs, EG; Michael Colvin, O; Pruitt, SK; Tyler, DS; Ueno, T	1
Frgala, T; Kalous, O; Proffitt, RT; Reynolds, CP	1
Kang, MH; Reynolds, CP; Singh, H; Tagde, A	1
Campana, LG; De Mattei, M; De Terlizzi, F; Ongaro, A; Pellati, A; Rossi, CR	1
Anderson, CP; Bailey, HH; Groshen, S; Hasenauer, B; Maris, JM; Matthay, KK; Neglia, JP; Perentesis, JP; Reynolds, CP; Seeger, RC; Villablanca, JG	1
Anderson, CP; Cho, H; Cohn, SL; Czarnecki, S; Goodarzian, F; Groshen, S; Hasenauer, CE; Kang, MH; Lai, H; Marachelian, A; Maris, JM; Matthay, KK; Reynolds, CP; Shimada, H; Tsao-Wei, D; Villablanca, JG; Volchenboum, SL	1

Reviews

2 review(s) available for buthionine sulfoximine and melphalan

Article	Year
The role of glutathione in drug resistance. Cancer treatment reviews, 1990, Volume: 17 Suppl A Topics: Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; DNA Repair; Drug Resistance; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms	1990
Clinical studies of reversal of drug resistance based on glutathione. Chemico-biological interactions, 1998, Apr-24, Volume: 111-112 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Clinical Trials as Topic; Drug Resistance; Female; Glutathione; Humans; Male; Melphalan; Neoplasms	1998

Trials

6 trial(s) available for buthionine sulfoximine and melphalan

Article	Year
Time-dependent pharmacodynamic models in cancer chemotherapy: population pharmacodynamic model for glutathione depletion following modulation by buthionine sulfoximine (BSO) in a Phase I trial of melphalan and BSO. Cancer research, 1995, Oct-15, Volume: 55, Issue:20 Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Enzyme Inhibitors; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Neoplasms; Neutrophils	1995
Phase I clinical trial of intravenous L-buthionine sulfoximine and melphalan: an attempt at modulation of glutathione. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:1 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Female; Glutathione; Humans; Infusions, Intravenous; Male; Melphalan; Methionine Sulfoximine; Middle Aged; Neoplasms	1994
Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:1 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Linear Models; Male; Melphalan; Methionine Sulfoximine; Middle Aged; Nausea; Neoplasm Recurrence, Local; Neoplasms; Neutropenia; Neutrophils; Radiography; Vomiting	1996
Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan. Journal of the National Cancer Institute, 1997, Dec-03, Volume: 89, Issue:23 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Drug Administration Schedule; Female; Glutathione; Humans; Infusions, Intravenous; Lymphocytes; Male; Melphalan; Middle Aged; Neoplasms; Treatment Outcome	1997
Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma. Pediatric blood & cancer, 2015, Volume: 62, Issue:10 Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Child; Chromatography, High Pressure Liquid; Female; Glutathione; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Melphalan; Neoplasm Recurrence, Local; Neuroblastoma; Pilot Projects	2015
A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma. Pediatric blood & cancer, 2016, Volume: 63, Issue:8 Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Child; Child, Preschool; Drug Synergism; Female; Glutamate-Cysteine Ligase; Glutathione; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Male; Melphalan; Myeloablative Agonists; Neoplasm Recurrence, Local; Neuroblastoma	2016

Other Studies

61 other study(ies) available for buthionine sulfoximine and melphalan

Article	Year
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Relationship between melanogenesis, glutathione levels and melphalan toxicity in human melanoma cells. Melanoma research, 1992, Volume: 2, Issue:5-6 Topics: Bucladesine; Buthionine Sulfoximine; Cell Differentiation; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Eye Neoplasms; Glutathione; Glutathione Transferase; Humans; Kinetics; Melanins; Melanoma; Melphalan; Methionine Sulfoximine; Microscopy, Electron; Monophenol Monooxygenase; Neoplasm Staging; Skin Neoplasms; Tumor Cells, Cultured	1992
Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine. Correlation with enhanced alkylating agent cytotoxicity to human melanoma cells in vitro. Biochemical pharmacology, 1992, Oct-06, Volume: 44, Issue:7 Topics: Buthionine Sulfoximine; Carmustine; Cell Division; Cell Nucleus; Cytosol; Doxorubicin; Drug Synergism; Glutathione; Glutathione Disulfide; Humans; Melanoma; Melphalan; Methionine Sulfoximine; Oxidation-Reduction; Tumor Cells, Cultured	1992
Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity. Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:5 Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Survival; Chlorambucil; DNA; Drug Interactions; Drug Resistance; Glutathione; Glutathione Transferase; Mammary Neoplasms, Experimental; Mechlorethamine; Melphalan; Methionine Sulfoximine; Rats; RNA, Messenger; Tumor Cells, Cultured	1992
Melanoma cytotoxicity of buthionine sulfoximine (BSO) alone and in combination with 3,4-dihydroxybenzylamine and melphalan. The Journal of investigative dermatology, 1992, Volume: 99, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Dopamine; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Melanoma; Melanoma, Experimental; Melphalan; Methionine Sulfoximine; Mice; Tumor Cells, Cultured	1992
Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results. Journal of the National Cancer Institute, 1992, Feb-19, Volume: 84, Issue:4 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Middle Aged; Neoplasms	1992
Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrier. Cancer chemotherapy and pharmacology, 1991, Volume: 29, Issue:2 Topics: 2-Naphthylamine; Amino Acid Transport Systems; Animals; Azaserine; Blood-Brain Barrier; Brain; Buthionine Sulfoximine; Carrier Proteins; Diazooxonorleucine; Isoxazoles; Male; Melphalan; Methionine Sulfoximine; Nitrogen Mustard Compounds; Rats; Rats, Inbred Strains	1991
Reversal of melphalan resistance in vivo and in vitro by modulation of glutathione metabolism. Biochemical pharmacology, 1991, Jul-05, Volume: 42, Issue:2 Topics: Buthionine Sulfoximine; Cell Survival; Drug Resistance; Glutathione; Glutathione Transferase; Humans; Melphalan; Methionine Sulfoximine; Multiple Myeloma; Neoplasm Transplantation; Tumor Cells, Cultured	1991
Development and characterization of a melphalan-resistant human multiple myeloma cell line. Cancer research, 1991, Feb-01, Volume: 51, Issue:3 Topics: Alkylating Agents; Buthionine Sulfoximine; Cell Survival; DNA, Neoplasm; Drug Resistance; Glutathione; Humans; Karyotyping; Melphalan; Methionine Sulfoximine; Multiple Myeloma; Myeloma Proteins; Tumor Cells, Cultured	1991
The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells. Biochemical pharmacology, 1991, Feb-15, Volume: 41, Issue:4 Topics: Buthionine Sulfoximine; Cell Nucleus; Drug Resistance; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured	1991
Intercellular transfer of drug resistance. Cancer research, 1991, Feb-15, Volume: 51, Issue:4 Topics: Antimetabolites; Buthionine Sulfoximine; Cell Communication; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; DNA; DNA Damage; Drug Resistance; Female; Flow Cytometry; Glutathione; Humans; In Vitro Techniques; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tetradecanoylphorbol Acetate	1991
Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers. Cancer letters, 1991, Volume: 56, Issue:1 Topics: Alkylating Agents; Animals; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma 256, Walker; Carmustine; Cell Division; Cell Line; Chlorambucil; Cisplatin; Drug Antagonism; Drug Resistance; Glutathione Transferase; Gossypol; Humans; In Vitro Techniques; Isomerism; Melphalan; Methionine Sulfoximine; Rats	1991
Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine. Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Buthionine Sulfoximine; Drug Synergism; Glutathione; Intestines; Kidney; Liver; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Nude; Muscles; Time Factors; Weight Loss	1991
Enhancement of melphalan (L-PAM) toxicity by reductive metabolites of 1-methyl-2-nitroimidazole, a model nitroimidazole chemosensitizing agent. Biochemical pharmacology, 1990, Dec-15, Volume: 40, Issue:12 Topics: Buthionine Sulfoximine; Cell Survival; Drug Synergism; Glutathione; Humans; In Vitro Techniques; Melphalan; Methionine Sulfoximine; Nitroimidazoles; Oxidation-Reduction; Structure-Activity Relationship; Tumor Cells, Cultured	1990
Changes in glutathione content and resistance to anticancer agents in human stomach cancer cells induced by treatments with melphalan in vitro. Cancer research, 1990, Jun-15, Volume: 50, Issue:12 Topics: Buthionine Sulfoximine; Cell Cycle; Cell Survival; Drug Screening Assays, Antitumor; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Stomach Neoplasms; Time Factors; Tumor Cells, Cultured	1990
Effects of L-phenylalanine mustard and L-buthionine sulfoximine on murine and human hematopoietic progenitor cells in vitro. Cancer research, 1990, Jul-01, Volume: 50, Issue:13 Topics: Animals; Buthionine Sulfoximine; Colony-Forming Units Assay; Drug Synergism; Female; Hematopoietic Stem Cells; Humans; Melphalan; Methionine Sulfoximine; Mice; Time Factors	1990
Flow cytometric analysis of DNA damage and repair in the cells resistant to alkylating agents. Cancer research, 1990, Aug-01, Volume: 50, Issue:15 Topics: Alkylating Agents; Antibodies, Monoclonal; Buthionine Sulfoximine; Cell Line; Cell Survival; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Kinetics; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured	1990
Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs. Cancer research, 1986, Volume: 46, Issue:6 Topics: Antineoplastic Agents; Bleomycin; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cisplatin; Glutathione; Humans; Lung; Lung Neoplasms; Melphalan; Methionine Sulfoximine; Neoplasms; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Zinostatin	1986
Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. Cancer research, 1989, Dec-15, Volume: 49, Issue:24 Pt 1 Topics: Animals; Buthionine Sulfoximine; Drug Interactions; Drug Resistance; Female; Glutathione; Glutathione Transferase; Humans; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Rhabdomyosarcoma; Transplantation, Heterologous; Vincristine	1989
[Cellular pharmacokinetics of melphalan alone or in combination on human lymphoma or lymphoblasts]. Bulletin du cancer, 1989, Volume: 76, Issue:8 Topics: Antimetabolites; Blastomeres; Burkitt Lymphoma; Buthionine Sulfoximine; Cell Line; Etoposide; Humans; Lymphocytes; Melphalan; Methionine Sulfoximine; Verapamil	1989
Pharmacokinetics of buthionine sulfoximine (NSC 326231) and its effect on melphalan-induced toxicity in mice. Cancer research, 1989, Oct-01, Volume: 49, Issue:19 Topics: Administration, Oral; Animals; Buthionine Sulfoximine; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Interactions; Glutathione; Half-Life; Injections, Intravenous; Liver; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Premedication	1989
Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. Journal of the National Cancer Institute, 1989, Apr-05, Volume: 81, Issue:7 Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Drug Interactions; Female; Glioma; Glutathione; Humans; Male; Medulloblastoma; Melphalan; Methionine Sulfoximine; Mice; Mice, Nude; Neoplasm Transplantation	1989
Detection of DNA damage in individual cells by flow cytometric analysis using anti-DNA monoclonal antibody. Experimental cell research, 1987, Volume: 170, Issue:2 Topics: Alkylating Agents; Antibodies, Monoclonal; Buthionine Sulfoximine; Cell Cycle; Cell Survival; DNA Damage; DNA, Single-Stranded; Endonucleases; Flow Cytometry; HeLa Cells; Hot Temperature; Humans; Melphalan; Methionine Sulfoximine; Nitrogen Mustard Compounds; Single-Strand Specific DNA and RNA Endonucleases	1987
Induction of hepatic veno-occlusive disease in dogs. The American journal of pathology, 1987, Volume: 126, Issue:1 Topics: Animals; Busulfan; Buthionine Sulfoximine; Cyclophosphamide; Disease Models, Animal; Dog Diseases; Dogs; Hepatic Veno-Occlusive Disease; Liver; Melphalan; Methionine Sulfoximine; Methotrexate; Monocrotaline; Pyrrolizidine Alkaloids; Radiation Injuries, Experimental; Radiography	1987
Selective enhancement of hypoxic cell killing by melphalan via thiol depletion: in vitro studies with hypoxic cell sensitizers and buthionine sulfoximine. Journal of the National Cancer Institute, 1985, Volume: 74, Issue:1 Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Drug Synergism; Etanidazole; Melphalan; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Sulfhydryl Compounds	1985
Cellular glutathione levels and sensitivity to radiation and antineoplastic agents in human ovarian cancer. Progress in clinical and biological research, 1988, Volume: 276 Topics: Buthionine Sulfoximine; Cell Survival; Cisplatin; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured	1988
Effect of D,L-buthionine-S,R-sulfoximine on cytotoxicity and DNA cross-linking induced by bifunctional DNA-reactive cytostatic drugs in human melanoma cells. Cancer research, 1988, Jan-01, Volume: 48, Issue:1 Topics: Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cell Survival; Cross-Linking Reagents; DNA; Drug Synergism; Glutathione; Humans; Melanoma; Melphalan; Methionine Sulfoximine; Tumor Cells, Cultured	1988
Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. Cancer research, 1988, May-15, Volume: 48, Issue:10 Topics: Animals; Buthionine Sulfoximine; Female; Glutathione; Humans; Male; Medulloblastoma; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous; Tumor Cells, Cultured	1988
Reduced thiol content in L1210 cells treated with BSO increases DNA crosslinking by melphalan. Biochemical and biophysical research communications, 1987, Apr-14, Volume: 144, Issue:1 Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cross-Linking Reagents; DNA Damage; DNA, Neoplasm; Glutathione; Leukemia L1210; Melphalan; Methionine Sulfoximine; Mice; Sulfhydryl Compounds	1987
Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on human and murine tumor cells. Investigational new drugs, 1986, Volume: 4, Issue:4 Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Female; Glutathione; Humans; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms; Sulfhydryl Compounds	1986
Effects of glutathione depletion on the cytotoxicity of agents toward a human colonic tumour cell line. British journal of cancer, 1987, Volume: 55, Issue:6 Topics: Antimetabolites; Antineoplastic Agents, Phytogenic; Buthionine Sulfoximine; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Naphthols; Naphthoquinones; Sesquiterpenes; Sesquiterpenes, Guaiane; Vitamin K	1987
In vivo modulation of glutathione by buthionine sulfoximine: effect on marrow response to melphalan. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7 Topics: Animals; Bone Marrow; Buthionine Sulfoximine; Drug Synergism; Female; Glutathione; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred C3H	1986
Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione. Biochemical pharmacology, 1987, Jan-01, Volume: 36, Issue:1 Topics: Animals; Buthionine Sulfoximine; Colony-Forming Units Assay; Drug Resistance; Drug Synergism; Female; Glutathione; Histocytochemistry; Humans; Melphalan; Methionine Sulfoximine; Mice; Mice, Nude; Ovarian Neoplasms	1987
Chemosensitization of L-phenylalanine mustard by the thiol-modulating agent buthionine sulfoximine. Cancer research, 1987, Mar-15, Volume: 47, Issue:6 Topics: Animals; Buthionine Sulfoximine; Drug Synergism; Glutathione; Leukemia L1210; Male; Melphalan; Methionine Sulfoximine; Mice; Thymidine	1987
Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion. Biochemical pharmacology, 1985, Jul-15, Volume: 34, Issue:14 Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Cisplatin; Doxorubicin; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms	1985
Chemosensitization: do thiols matter? International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Synergism; Melphalan; Methionine Sulfoximine; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Sulfhydryl Compounds	1984
Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion. Cancer research, 1984, Volume: 44, Issue:11 Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Cystine; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Kinetics; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms	1984
Reduction in cellular glutathione by buthionine sulfoximine and sensitization of murine tumor cells resistant to L-phenylalanine mustard. Biochemical pharmacology, 1984, Feb-01, Volume: 33, Issue:3 Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Drug Resistance; Female; Glutathione; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred DBA; Neoplasms, Experimental	1984
Radiation resistance in a melphalan-resistant subline of a rat mammary carcinoma. Radiation research, 1994, Volume: 139, Issue:2 Topics: Animals; Buthionine Sulfoximine; Cell Cycle; Cell Division; Cell Survival; Drug Resistance; Glutathione Peroxidase; Glutathione Transferase; Mammary Neoplasms, Experimental; Melphalan; Methionine Sulfoximine; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Tumor Cells, Cultured	1994
In vivo therapeutic potential of combination thiol depletion and alkylating chemotherapy. British journal of cancer, 1993, Volume: 68, Issue:6 Topics: Alkylating Agents; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Cells; Buthionine Sulfoximine; Cell Survival; Chromatography, High Pressure Liquid; Colony-Forming Units Assay; Drug Resistance; Female; Glutathione; Hematopoietic Stem Cells; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Sarcoma, Experimental	1993
Glutathione depletion increases the cytotoxicity of melphalan to PC-3, an androgen-insensitive prostate cancer cell line. Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:1 Topics: Buthionine Sulfoximine; Cell Survival; Glutathione; Humans; Male; Melphalan; Methionine Sulfoximine; Prostatic Neoplasms; Tumor Cells, Cultured	1993
Characteristics of the glutathione/glutathione-S-transferase detoxification system in melphalan resistant human prostate cancer cells. The Journal of urology, 1993, Volume: 150, Issue:1 Topics: Antineoplastic Agents; Blotting, Western; Buthionine Sulfoximine; Cell Division; Dose-Response Relationship, Drug; Drug Resistance; Glutathione; Glutathione Transferase; Humans; Male; Melphalan; Methionine Sulfoximine; Prostatic Neoplasms; Tumor Cells, Cultured	1993
Nitric oxide enhancement of melphalan-induced cytotoxicity. British journal of cancer, 1997, Volume: 76, Issue:3 Topics: Animals; Buthionine Sulfoximine; Cricetinae; DNA Repair; Drug Synergism; Glutathione; Humans; Melphalan; Nitric Oxide; Tumor Cells, Cultured	1997
The effects of different antineoplastic agents and of pretreatment by modulators on three melanoma lines. Cancer, 1998, Feb-01, Volume: 82, Issue:3 Topics: Animals; Anisoles; Antineoplastic Agents; Buthionine Sulfoximine; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Ethacrynic Acid; Humans; In Vitro Techniques; Lomustine; Melanoma, Experimental; Melphalan; Mice; Monophenol Monooxygenase; Nitrosourea Compounds; Organophosphorus Compounds; Tumor Cells, Cultured	1998
Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. British journal of cancer, 1998, Volume: 77, Issue:2 Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Alkylating; Biological Transport, Active; Buthionine Sulfoximine; Cell Membrane; Chlorambucil; CHO Cells; Cricetinae; DNA-Binding Proteins; Drug Resistance; Glutathione; HeLa Cells; Humans; Leukotriene C4; Mass Spectrometry; Melphalan; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; MutS Homolog 3 Protein; Sequence Alignment; Tumor Cells, Cultured	1998
Buthionine sulphoximine alone and in combination with melphalan (L-PAM) is highly cytotoxic for human neuroblastoma cell lines. European journal of cancer (Oxford, England : 1990), 1997, Volume: 33, Issue:12 Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Buthionine Sulfoximine; Drug Screening Assays, Antitumor; Drug Synergism; Glutathione; Humans; Melphalan; Neuroblastoma; Tumor Cells, Cultured	1997
L-S,R-buthionine sulfoximine: historical development and clinical issues. Chemico-biological interactions, 1998, Apr-24, Volume: 111-112 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Drug Resistance; Enzyme Inhibitors; Female; Glutamate-Cysteine Ligase; History, 20th Century; Humans; Male; Melphalan; Neoplasms	1998
Melanin content and downregulation of glutathione S-transferase contribute to the action of L-buthionine-S-sulfoximine on human melanoma. Chemico-biological interactions, 1998, Apr-24, Volume: 111-112 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Buthionine Sulfoximine; Carmustine; Down-Regulation; Drug Resistance; Enzyme Inhibitors; Female; Glutamate-Cysteine Ligase; Glutathione Transferase; Humans; Melanins; Melanoma; Melphalan; Ovarian Neoplasms; Tumor Cells, Cultured	1998
Potentiation of the cytostatic effect of melphalan on colorectal cancer hepatic metastases by infusion of buthionine sulfoximine (BSO) in the rat: enhanced tumor glutathione depletion by infusion of BSO in the hepatic artery. Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:2 Topics: Animals; Buthionine Sulfoximine; Colorectal Neoplasms; Drug Synergism; Glutathione; Infusions, Intra-Arterial; Liver Neoplasms, Experimental; Male; Melphalan; Rats	1999
Effect of glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by melphalan (L-phenylalanine mustard) in human colorectal cancer cells. Biochemical pharmacology, 1999, Aug-15, Volume: 58, Issue:4 Topics: Antineoplastic Agents, Alkylating; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Line; Colorectal Neoplasms; Glutathione; HT29 Cells; Humans; Melphalan; Tumor Cells, Cultured	1999
Mechanisms involved in the potentiation of melphalan by the bioreductive compound THNLA-1 in vitro. Oncology research, 1999, Volume: 11, Issue:8 Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Hypoxia; Cell Line; Comet Assay; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Repair; Drug Synergism; Glutathione; Melphalan; Protein Biosynthesis; Proteins; Radiation-Sensitizing Agents; RNA; Tacrine	1999
Synergism of buthionine sulfoximine and melphalan against neuroblastoma cell lines derived after disease progression. Medical and pediatric oncology, 2000, Volume: 35, Issue:6 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Buthionine Sulfoximine; Child; Disease Progression; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Melphalan; Neuroblastoma; Tumor Cells, Cultured	2000
Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells. The role of intracellular oxidation. The Journal of biological chemistry, 2001, Dec-14, Volume: 276, Issue:50 Topics: Adenosine Triphosphate; Alkylating Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Buthionine Sulfoximine; Camptothecin; Cell Death; Cisplatin; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin; Enzyme Inhibitors; Etoposide; Flow Cytometry; Glutathione; Humans; Hydrogen Peroxide; Hypoxia; Immunoblotting; Melphalan; Membrane Potentials; Mitochondria; Monocytes; Necrosis; Nucleic Acid Synthesis Inhibitors; Oxygen; Radiation-Protective Agents; Reactive Oxygen Species; Spectrometry, Fluorescence; Time Factors; Topoisomerase I Inhibitors; U937 Cells	2001
Buthionine sulfoximine and myeloablative concentrations of melphalan overcome resistance in a melphalan-resistant neuroblastoma cell line. Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:8 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Buthionine Sulfoximine; Cell Survival; Child; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Glutathione; Humans; Melphalan; Neuroblastoma; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured	2001
Synergistic cytotoxicity of buthionine sulfoximine (BSO) and intensive melphalan (L-PAM) for neuroblastoma cell lines established at relapse after myeloablative therapy. Bone marrow transplantation, 2002, Volume: 30, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Glutathione; Humans; Melphalan; Myeloablative Agonists; Neuroblastoma; Recurrence; Tumor Cells, Cultured	2002
Transduction of green fluorescent protein increased oxidative stress and enhanced sensitivity to cytotoxic drugs in neuroblastoma cell lines. Molecular cancer therapeutics, 2003, Volume: 2, Issue:9 Topics: Antineoplastic Agents; Apoptosis; B7-1 Antigen; Buthionine Sulfoximine; Carboplatin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Glutathione; Green Fluorescent Proteins; Humans; Lentivirus; Luminescent Proteins; Melphalan; Mutation; Neuroblastoma; Oxidative Stress; Transduction, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2003
Modulation of resistance to regional chemotherapy in the extremity melanoma model. Surgery, 2004, Volume: 136, Issue:2 Topics: Animals; Buthionine Sulfoximine; Chemotherapy, Cancer, Regional Perfusion; Drug Resistance, Neoplasm; Female; Glutathione; Melanoma; Melphalan; Rats	2004
A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations. Molecular cancer therapeutics, 2007, Volume: 6, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Cell Proliferation; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Eosine Yellowish-(YS); Fenretinide; Fluorescent Dyes; Humans; Leukemia; Melphalan; Microscopy, Fluorescence; Neuroblastoma; Protein Kinase C; Sphingosine; Tumor Cells, Cultured; Tumor Stem Cell Assay	2007
The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma. Blood cancer journal, 2014, Jul-18, Volume: 4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Buthionine Sulfoximine; Disease-Free Survival; Drug Synergism; Female; Humans; Melphalan; Mice; Mice, Nude; Multiple Myeloma; Random Allocation; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2014
Enhancement of melphalan activity by buthionine sulfoximine and electroporation in melanoma cells. Anti-cancer drugs, 2015, Volume: 26, Issue:3 Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Electroporation; Glutathione; Humans; Melanoma; Melphalan	2015