Compounds > buthionine sulfoximine
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buthionine sulfoximine and glutathione disulfide

buthionine sulfoximine has been researched along with glutathione disulfide in 75 studies

Research

Studies (75)

TimeframeStudies, this research(%)All Research%
pre-19903 (4.00)18.7374
1990's30 (40.00)18.2507
2000's27 (36.00)29.6817
2010's15 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guenthner, TM; Jevtović-Todorović, V1
Allen, KG; Chao, PY1
Belzer, FO; Boudjema, K; Lindell, SL; Southard, JH1
Auld, PA; Jain, A; Mårtensson, J; Meister, A; Stole, E1
Carlsson, B; Gustafsson, J; Larsson, A1
Chen, G; Zeller, WJ1
Lewko, WM1
Earnshaw, BA; Johnson, MA1
Hill, TD; Radha, E; Rao, GH; White, JG1
Berglund, T; Komlos, P; Ohlsson, AB; Rydström, J1
Gardiner, CS; Reed, DJ1
Favilli, F; Ferretti, P; Iantomasi, T; Marraccini, P; Tonelli, F; Vincenzini, MT1
Andrade, F; Anzueto, A; Brassard, J; Jenkinson, SG; Lawrence, RA; Levine, SM; Maxwell, LC; Morales, CF1
Hollaar, L; Le, CT; van der Laarse, A; van der Valk, EJ1
Jornot, L; Junod, AF1
Harris, C; Hiranruengchok, R1
Balasubramanian, KA; Benard, O2
Elliott, SJ; Henschke, PN1
Benito, M; Carrizosa, R; Fabregat, I; Martínez-Honduvilla, C; Mesa, ML1
Maitra, I; Packer, L; Serbinova, E; Tritschler, HJ1
Lash, LH; Pegouske, DM; Putt, DA; Schare, JM; Visarius, TM1
Clark, JB; Duchen, MR; Peuchen, S1
Luperchio, S; Tamir, S; Tannenbaum, SR1
Buè, MC; Ciriolo, MR; De Vito, P; Garaci, E; Incerpi, S; Lafavia, E; Palamara, AT; Rotilio, G1
Dringen, R; Hamprecht, B1
Casley, WL; Moon, TW; Otto, DM; Sen, CK1
Khanna, S; Packer, L; Reznick, AZ; Roy, S; Sen, CK1
Favilli, F; Iantomasi, T; Marraccini, P; Vincenzini, MT1
Brigelius-Flohé, R; Friedrichs, B; Müller, C1
Matern, S; Purucker, E; Roeb, E; Winograd, R1
Bojes, HK; Cohen, GM; Feng, X; Kehrer, JP1
Corrales, FJ; Mato, JM; Ruiz, F1
Chen, HW; Chiang, T; Lii, CK; Wang, CY1
Chen, TS; Song, H1
Hadari-Naor, I; Koren, R; Liberman, UA; Ravid, A; Rotem, C; Zuck, E1
Boget, S; Cereser, C; Parvaz, P; Revol, A1
Aw, TY; Fujimoto, K; Iwakiri, R; Noda, T1
Haddad, JJ2
Aw, TY; Fujimoto, K; Iwakiri, R; Noda, T; Rhoads, CA1
Awazuhara, M; Chino, M; Fujiwara, T; Hayashi, H; Kim, H; Kim, SG1
Chen, CF; Ho, LT; Lin, AM1
Dudek, E; Lu, M; Reddan, J; Shang, F; Taylor, A1
Ehrhart, J; Zeevalk, GD1
Foyer, CH; Gómez, L; Guy, M; Kiddle, G; Mittova, V; Tal, M; Theodoulou, FL; Volokita, M1
Iwabuchi, M; Mino, M; Ogawa, K; Yanagida, M1
Ogawa, K; Senda, K1
Kaga, M; Lewis, JB; Lockwood, PE; Messer, RL; Noda, M; Sano, H; Wataha, JC1
Gardiner, CS; Gushansky, G; Mason, A; Matt, A; Salmen, JJ; Skufca, F1
Choi, Y; Chung, SC; Huh, YJ; Jeong, DW; Kim, H; Kim, HH; Kim, HJ; Kim, JM; Kwon, SB; Lee, SH; Lee, SY; Min, BM; So, H; Song, H1
Andringa, KK; Aykin-Burns, N; Coleman, MC; Domann, FE; Hitchler, MJ; Spitz, DR; Walsh, SA1
Dwarte, TM; Luty, A; Raftos, JE; Willcock, CJ1
Gao, Y; Gu, LH; Jones, DP; Levin, MS; Mwangi, S; Rubin, DC; Srinivasan, S; Tian, J; Wang, L; Washizawa, N; Ziegler, TR1
Belmonte, MF; Stasolla, C1
Grant, MH; Henderson, C; Kupper, C; Lalaouni, A1
Pat, SW; Yang, MS; Yu, LC1
Doneanu, CE; Niture, SK; Pattabiraman, N; Srivenugopal, KS; Velu, CS1
Balbis, E; De Ciucis, C; Domenicotti, C; Furfaro, A; Marengo, B; Marinari, UM; Nitti, M; Patriarca, S; Pronzato, MA; Traverso, N1
Cheng, B; Fan, R; Pruett, SB; Sebastian, T; Tan, W1
Carlson, L; Chen, W; Foll, R; Guan, X; Hanson, S; Matthees, DP; Palakurthi, S; Seefeldt, T; Stoebner, A; Zhao, Y1
Iyamu, EW1
Borisenko, GG; Demina, IA; Galyamina, MA; Govorun, VM; Lazarev, VN; Levitskiy, SA; Serebryakova, MV; Shkarupeta, MM1
Gokce, G; Kerry, Z; Oran, I; Ozsarlak-Sozer, G; Topcu, Z1
Gaskins, HR; Henderson, JL; Henry, JJ; Kenis, PJ; Kolossov, VL; Lin, C; Rund, LA; Schook, LB; Timp, G; Trump, L; Tsvid, G1
Catarzi, S; Favilli, F; Iantomasi, T; Marcucci, T; Picariello, L; Romagnoli, C; Tonelli, F; Vincenzini, MT1
Gius, D; Mapuskar, KA; Mattson, DM; Scarbrough, PM; Spitz, DR; Watson, WH1
Brandi, ML; Favilli, F; Galli, G; Iantomasi, T; Marcucci, G; Mavilia, C; Romagnoli, C; Tanini, A; Vincenzini, MT; Zonefrati, R1
Iantomasi, T; Marcucci, T; Picariello, L; Romagnoli, C; Tonelli, F; Vincenzini, MT1
Duong, DM; Go, YM; Jones, DP; Liang, Y; Orr, M; Pennell, KD; Roede, JR; Seyfried, NT; Walker, DI1
Beaudoin, JN; Bica, DE; DiLiberto, SJ; Gaskins, HR; Hanafin, WP; Kenis, PJ; Kolossov, VL1
Hao, J; Huang, K; Liang, Z; Luo, Y; Wang, Y; Wu, W; Xu, W; Yang, Z; Zhao, W1
Chen, Y; Duan, S; Duan, Y; Han, J; Li, X; Li, Y; Ma, X; Sun, L; Xiang, R; Yang, X; Yao, H1
Chin, DC; Hsieh, CC; Lin, HY; Yeh, KW1
Babu V, S; Chen, K; Li, C; Li, J; Lin, H; Lin, L; Qin, Z; Sun, L; Tu, J1

Other Studies

75 other study(ies) available for buthionine sulfoximine and glutathione disulfide

ArticleYear
Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine. Correlation with enhanced alkylating agent cytotoxicity to human melanoma cells in vitro.
    Biochemical pharmacology, 1992, Oct-06, Volume: 44, Issue:7

    Topics: Buthionine Sulfoximine; Carmustine; Cell Division; Cell Nucleus; Cytosol; Doxorubicin; Drug Synergism; Glutathione; Glutathione Disulfide; Humans; Melanoma; Melphalan; Methionine Sulfoximine; Oxidation-Reduction; Tumor Cells, Cultured

1992
Glutathione production in copper-deficient isolated rat hepatocytes.
    Free radical biology & medicine, 1992, Volume: 12, Issue:2

    Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Copper; Free Radicals; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; In Vitro Techniques; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Superoxide Dismutase

1992
Changes in glutathione concentration in hypothermically perfused dog kidneys.
    The Journal of laboratory and clinical medicine, 1991, Volume: 117, Issue:2

    Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cold Temperature; Dithionitrobenzoic Acid; Dogs; Glutathione; Glutathione Disulfide; Kidney; Methionine Sulfoximine; Organ Preservation; Osmolar Concentration; Perfusion; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Time Factors; Tissue Distribution

1991
Glutathione deficiency leads to mitochondrial damage in brain.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Mar-01, Volume: 88, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Brain; Buthionine Sulfoximine; Female; Glutathione; Glutathione Disulfide; Male; Methionine Sulfoximine; Microscopy, Electron; Mitochondria; Mitochondrial Swelling; Rats; Rats, Inbred Strains

1991
Cholesterol synthesis in patients with glutathione deficiency.
    European journal of clinical investigation, 1990, Volume: 20, Issue:4

    Topics: Buthionine Sulfoximine; Cholesterol; Female; Fibroblasts; Glutathione; Glutathione Disulfide; Humans; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Male; Methionine Sulfoximine

1990
In vitro investigations on induction and reversal of cisplatin resistance in a rat ovarian tumor cell line.
    Journal of cancer research and clinical oncology, 1990, Volume: 116, Issue:5

    Topics: Animals; Antimetabolites; Benzamides; Buthionine Sulfoximine; Cell Line; Cisplatin; DNA; Drug Resistance; Female; Glutathione; Glutathione Disulfide; In Vitro Techniques; Methionine Sulfoximine; Ovarian Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Rats

1990
Glutathione levels in cultured heart cells. Influence of buthionine sulfoximine, an inhibitor of glutathione synthesis.
    Biochemical pharmacology, 1987, Jan-15, Volume: 36, Issue:2

    Topics: Animals; Buthionine Sulfoximine; Cell Division; Cells, Cultured; Glutathione; Glutathione Disulfide; Heart; Kinetics; Methionine Sulfoximine; Myocardium; Rats; Rats, Inbred Strains

1987
The effect of glutathione on development in wild carrot suspension cultures.
    Biochemical and biophysical research communications, 1985, Dec-31, Volume: 133, Issue:3

    Topics: Buthionine Sulfoximine; Cell Division; Glutathione; Glutathione Disulfide; Methionine Sulfoximine; Plant Development; Plants

1985
Glutathione levels in human platelets display a circadian rhythm in vitro.
    Thrombosis research, 1985, Dec-15, Volume: 40, Issue:6

    Topics: Adult; Blood Platelets; Buthionine Sulfoximine; Circadian Rhythm; Darkness; Erythrocytes; Glutathione; Glutathione Disulfide; Humans; In Vitro Techniques; Light; Methionine Sulfoximine; Oxidation-Reduction; Work Schedule Tolerance

1985
Plant defense metabolism is increased by the free radical-generating compound AAPH.
    Free radical biology & medicine, 1995, Volume: 19, Issue:3

    Topics: Amidines; Antimetabolites; Buthionine Sulfoximine; Cells, Cultured; Dose-Response Relationship, Drug; Free Radicals; Glutathione; Glutathione Disulfide; Kinetics; Lipid Peroxidation; Methionine Sulfoximine; Phenols; Phenylalanine Ammonia-Lyase; Pisum sativum; Plant Physiological Phenomena; Plants

1995
Glutathione redox cycle-driven recovery of reduced glutathione after oxidation by tertiary-butyl hydroperoxide in preimplantation mouse embryos.
    Archives of biochemistry and biophysics, 1995, Aug-01, Volume: 321, Issue:1

    Topics: Animals; Antimetabolites; Blastocyst; Buthionine Sulfoximine; Carmustine; Dose-Response Relationship, Drug; Female; Glutathione; Glutathione Disulfide; In Vitro Techniques; Kinetics; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Oxidation-Reduction; Peroxides; Reactive Oxygen Species; Superovulation; tert-Butylhydroperoxide

1995
Glutathione metabolism in Crohn's disease.
    Biochemical medicine and metabolic biology, 1994, Volume: 53, Issue:2

    Topics: Administration, Oral; Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Crohn Disease; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Transferase; Humans; Ileum; Isoxazoles; Jejunum; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley

1994
Buthionine sulfoximine treatment impairs rat diaphragm function.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:4 Pt 1

    Topics: Analysis of Variance; Animals; Buthionine Sulfoximine; Diaphragm; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Male; Methionine Sulfoximine; Muscle Contraction; Rats; Rats, Sprague-Dawley; Respiratory Function Tests

1994
Buthionine sulfoximine reduces the protective capacity of myocytes to withstand peroxide-derived free radical attack.
    Journal of molecular and cellular cardiology, 1993, Volume: 25, Issue:5

    Topics: Animals; Benzene Derivatives; Buthionine Sulfoximine; Cell Death; Cells, Cultured; Free Radicals; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Heart; Heart Rate; Lipid Peroxidation; Methionine Sulfoximine; Myocardium; NADP; Rats; Rats, Wistar

1993
Variable glutathione levels and expression of antioxidant enzymes in human endothelial cells.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

    Topics: Blotting, Northern; Buthionine Sulfoximine; Catalase; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Humans; Hypoxanthine; Hypoxanthines; L-Lactate Dehydrogenase; Maleates; Methionine Sulfoximine; Oxygen; RNA, Messenger; Superoxide Dismutase; Umbilical Veins; Xanthine Oxidase

1993
Glutathione oxidation and embryotoxicity elicited by diamide in the developing rat conceptus in vitro.
    Toxicology and applied pharmacology, 1993, Volume: 120, Issue:1

    Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Carmustine; Chromatography, High Pressure Liquid; Diamide; Embryo, Mammalian; Female; Glutaredoxins; Glutathione; Glutathione Disulfide; In Vitro Techniques; Methionine Sulfoximine; Oxidation-Reduction; Oxidoreductases; Protein Disulfide Reductase (Glutathione); Rats; Rats, Sprague-Dawley

1993
Effect of oxidant exposure on thiol status in the intestinal mucosa.
    Biochemical pharmacology, 1993, May-25, Volume: 45, Issue:10

    Topics: Animals; Antimetabolites; Biological Transport; Buthionine Sulfoximine; Epithelium; Glutathione; Glutathione Disulfide; Intestinal Mucosa; Methionine Sulfoximine; Oxidants; Oxidation-Reduction; Rats; Rats, Wistar; Reactive Oxygen Species; Sulfhydryl Compounds

1993
Oxidized glutathione decreases luminal Ca2+ content of the endothelial cell ins(1,4,5)P3-sensitive Ca2+ store.
    The Biochemical journal, 1995, Dec-01, Volume: 312 ( Pt 2)

    Topics: Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Calcium; Carmustine; Cattle; Cells, Cultured; Cytosol; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Hydroquinones; Inositol 1,4,5-Trisphosphate; Methionine Sulfoximine; Oxidants; Peroxides; Pulmonary Artery; Signal Transduction; tert-Butylhydroperoxide

1995
Changes in rat liver gene expression induced by thioacetamide: protective role of S-adenosyl-L-methionine by a glutathione-dependent mechanism.
    Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:3

    Topics: Actins; Alanine Transaminase; Albumins; Animals; Buthionine Sulfoximine; Enzyme Inhibitors; Gene Expression; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Reductase; Liver; Male; Methionine Sulfoximine; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylmethionine; Thioacetamide

1996
Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats.
    Biochemical and biophysical research communications, 1996, Apr-16, Volume: 221, Issue:2

    Topics: Animals; Animals, Newborn; Ascorbic Acid; Buthionine Sulfoximine; Cataract; Female; Glutathione; Glutathione Disulfide; Lens, Crystalline; Methionine Sulfoximine; Pregnancy; Rats; Rats, Sprague-Dawley; Stereoisomerism; Thioctic Acid; Vitamin E

1996
Pathways of glutathione metabolism and transport in isolated proximal tubular cells from rat kidney.
    Biochemical pharmacology, 1996, Jul-26, Volume: 52, Issue:2

    Topics: Animals; Biological Transport; Buthionine Sulfoximine; Cells, Cultured; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Glutathione Disulfide; Isoxazoles; Kidney Tubules, Proximal; Male; Methionine Sulfoximine; Peroxides; Rats; Rats, Inbred F344; tert-Butylhydroperoxide

1996
Modulation of the glutathione redox state in adult astrocytes.
    Biochemical Society transactions, 1996, Volume: 24, Issue:3

    Topics: Adenosine Triphosphate; Animals; Astrocytes; Buthionine Sulfoximine; Cell Survival; Dinitrochlorobenzene; Energy Metabolism; Glutathione; Glutathione Disulfide; In Vitro Techniques; Naphthoquinones; Oxidation-Reduction; Peroxides; Rats; Rats, Wistar; tert-Butylhydroperoxide; Vitamin K 3

1996
NO-induced oxidative stress and glutathione metabolism in rodent and human cells.
    Free radical biology & medicine, 1996, Volume: 21, Issue:4

    Topics: Animals; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; CHO Cells; Cricetinae; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Reductase; Humans; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species

1996
Loss of GSH, oxidative stress, and decrease of intracellular pH as sequential steps in viral infection.
    The Journal of biological chemistry, 1997, Jan-31, Volume: 272, Issue:5

    Topics: Adsorption; Animals; Buthionine Sulfoximine; Cell Line; Cysteine; Disulfides; Dithionitrobenzoic Acid; Dithiothreitol; Dogs; Glutathione; Glutathione Disulfide; Hydrogen-Ion Concentration; Kidney; L-Lactate Dehydrogenase; Methionine; Oxidative Stress; Respirovirus; Sodium-Hydrogen Exchangers; Ultraviolet Rays; Virus Replication

1997
Effect of enterotoxin on glutathione status in the intestinal mucosa.
    Indian journal of biochemistry & biophysics, 1996, Volume: 33, Issue:5

    Topics: Animals; Buthionine Sulfoximine; Cholera Toxin; Cysteine; Endotoxins; Glutathione; Glutathione Disulfide; Intestinal Mucosa; Maleates; Rats; Sulfhydryl Compounds

1996
Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells.
    Brain research, 1997, Jun-06, Volume: 759, Issue:1

    Topics: Animals; Animals, Newborn; Astrocytes; Buthionine Sulfoximine; Catalase; Cells, Cultured; Enzyme Inhibitors; Glucose; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Half-Life; Hydrogen Peroxide; Oxidation-Reduction; Rats; Rats, Wistar

1997
Regulation of 3,3',4,4'-tetrachlorobiphenyl induced cytochrome P450 metabolism by thiols in tissues of rainbow trout.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1997, Volume: 117, Issue:3

    Topics: Analysis of Variance; Animals; Blotting, Western; Buthionine Sulfoximine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Oncorhynchus mykiss; Oxidation-Reduction; Polychlorinated Biphenyls; RNA, Messenger; Thioctic Acid

1997
Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa B activation in skeletal muscle-derived L6 cells.
    Biochemical and biophysical research communications, 1997, Aug-28, Volume: 237, Issue:3

    Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Line; Cell Nucleus; Glutathione; Glutathione Disulfide; Hydrogen Peroxide; Intercellular Adhesion Molecule-1; Kinetics; Mice; Muscle, Skeletal; NF-kappa B; Proline; Reactive Oxygen Species; Thiocarbamates; Tumor Necrosis Factor-alpha

1997
Glutathione involvement on the intestinal Na+-dependent D-glucose active transporter.
    Molecular and cellular biochemistry, 1998, Volume: 178, Issue:1-2

    Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Intestine, Small; Kinetics; Male; Monosaccharide Transport Proteins; Rats; Rats, Sprague-Dawley

1998
Inhibition of tumor necrosis factor-alpha- and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents.
    Arteriosclerosis, thrombosis, and vascular biology, 1998, Volume: 18, Issue:12

    Topics: Acetylcysteine; Arsenicals; Buthionine Sulfoximine; Cells, Cultured; E-Selectin; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Humans; Interleukin-1; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha

1998
Glutathione status in liver and plasma during development of biliary cirrhosis after bile duct ligation.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1998, Volume: 198, Issue:4

    Topics: Animals; Bile Ducts; Buthionine Sulfoximine; Glutathione; Glutathione Disulfide; Ligation; Liver; Liver Cirrhosis, Biliary; Male; Rats; Rats, Wistar; Time Factors

1998
Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3 withdrawal: relationship to caspase activity and the loss of glutathione.
    Cell death and differentiation, 1999, Volume: 6, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Buthionine Sulfoximine; Caspase 3; Caspases; Cell Line; Coumarins; Glutathione; Glutathione Disulfide; Hematopoietic Stem Cells; Interleukin-3; Lamin Type B; Lamins; Membrane Potentials; Mice; Mitochondria; Nuclear Proteins; Oligopeptides; Phosphatidylserines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protease Inhibitors; Proteins

1999
In vivo regulation by glutathione of methionine adenosyltransferase S-nitrosylation in rat liver.
    Journal of hepatology, 1999, Volume: 31, Issue:5

    Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Glutathione; Glutathione Disulfide; Kinetics; Liver; Methionine Adenosyltransferase; Nitric Oxide; Nitroso Compounds; Rats; Rats, Wistar

1999
Inhibition of tert-butyl hydroperoxide-induced cell membrane bleb formation by alpha-tocopherol and glutathione.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2000, Volume: 38, Issue:12

    Topics: Actins; Animals; Buthionine Sulfoximine; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Glutathione; Glutathione Disulfide; Hepatocytes; Image Processing, Computer-Assisted; Immunoblotting; L-Lactate Dehydrogenase; Microscopy, Phase-Contrast; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; tert-Butylhydroperoxide; Thiobarbituric Acid Reactive Substances; Vitamin E

2000
p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.
    Journal of biochemical and molecular toxicology, 2001, Volume: 15, Issue:1

    Topics: Acetaminophen; Acetylation; Alanine Transaminase; Aminophenols; Animals; Ascorbic Acid; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cysteine; Cystine; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Glutathione Disulfide; L-Iditol 2-Dehydrogenase; Liver; Male; Mice; Mice, Inbred C57BL

2001
Vitamin D is a prooxidant in breast cancer cells.
    Cancer research, 2001, Feb-15, Volume: 61, Issue:4

    Topics: Antimetabolites; Breast Neoplasms; Buthionine Sulfoximine; Calcitriol; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glyceraldehyde-3-Phosphate Dehydrogenases; Homeostasis; Humans; Oxidants; Oxidation-Reduction; Reactive Oxygen Species; Tumor Cells, Cultured

2001
Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death.
    Toxicology, 2001, Jun-21, Volume: 163, Issue:2-3

    Topics: Acetylcysteine; Adult; Buthionine Sulfoximine; Cell Death; Cell Division; Cell Survival; Cells, Cultured; Female; Fibroblasts; Fungicides, Industrial; Glutathione; Glutathione Disulfide; Glutathione Reductase; Humans; Lipid Peroxidation; Oxidation-Reduction; Thiobarbituric Acid Reactive Substances; Thiram

2001
Induction of mild intracellular redox imbalance inhibits proliferation of CaCo-2 cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:12

    Topics: Acetylcysteine; Buthionine Sulfoximine; Caco-2 Cells; Carmustine; Cell Division; Cell Survival; Cytoplasm; Diamide; Epidermal Growth Factor; Glutathione; Glutathione Disulfide; Humans; Kinetics; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Sulfhydryl Reagents

2001
The involvement of L-gamma-glutamyl-L-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signaling mediating MAPK(p38)-dependent regulation of pro-inflammatory cytokine production.
    Biochemical pharmacology, 2002, Jan-15, Volume: 63, Issue:2

    Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cells, Cultured; Cytokines; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Interleukin-6; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Tumor Necrosis Factor-alpha

2002
Exogenous cysteine and cystine promote cell proliferation in CaCo-2 cells.
    Cell proliferation, 2002, Volume: 35, Issue:2

    Topics: Antimetabolites; Blotting, Western; Buthionine Sulfoximine; Caco-2 Cells; Chromatography, High Pressure Liquid; Cyclin D1; Cysteine; Cystine; Flow Cytometry; G1 Phase; Glutathione; Glutathione Disulfide; Humans; Phosphorylation; Retinoblastoma Protein; S Phase

2002
Composition of seed storage proteins changed by glutathione treatment of soybeans.
    Bioscience, biotechnology, and biochemistry, 2002, Volume: 66, Issue:8

    Topics: Antigens, Plant; Buthionine Sulfoximine; Cotyledon; Cysteine; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Globulins; Glutathione; Glutathione Disulfide; Glycine max; Seed Storage Proteins; Soybean Proteins

2002
Neuroprotective effect of intermittent hypoxia on iron-induced oxidative injury in rat brain.
    Experimental neurology, 2002, Volume: 176, Issue:2

    Topics: Animals; Atmosphere Exposure Chambers; Brain; Buthionine Sulfoximine; Catalase; Disease Models, Animal; Drug Administration Routes; Female; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Hypoxia; Iron; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Wistar; Substantia Nigra; Superoxide Dismutase

2002
Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2.
    Free radical biology & medicine, 2003, Mar-01, Volume: 34, Issue:5

    Topics: Animals; Antioxidants; Ascorbic Acid; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Glutathione; Glutathione Disulfide; Hydrogen Peroxide; L-Lactate Dehydrogenase; Lens, Crystalline; Oxidants; Oxidation-Reduction; Oxidative Stress; Rabbits; Vitamin E

2003
Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures.
    Journal of neurochemistry, 2003, Volume: 86, Issue:6

    Topics: Animals; Antioxidants; Ascorbic Acid; Buthionine Sulfoximine; Chromans; Disulfides; Fluorescent Dyes; Glutathione; Glutathione Disulfide; Malonates; Mesencephalon; Mitochondria; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley

2003
Coordinate induction of glutathione biosynthesis and glutathione-metabolizing enzymes is correlated with salt tolerance in tomato.
    FEBS letters, 2003, Nov-20, Volume: 554, Issue:3

    Topics: Acclimatization; Buthionine Sulfoximine; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hydrogen Peroxide; Malondialdehyde; Oxidation-Reduction; Oxidative Stress; Plant Leaves; Plant Roots; Sodium Chloride; Solanum lycopersicum; Species Specificity; Up-Regulation

2003
Reduced glutathione is a novel regulator of vernalization-induced bolting in the rosette plant Eustoma grandiflorum.
    Plant & cell physiology, 2004, Volume: 45, Issue:2

    Topics: Buthionine Sulfoximine; Cysteine; Enzyme Inhibitors; Gentianaceae; Glutathione; Glutathione Disulfide; Light; Oxidative Stress; Photic Stimulation; Reactive Oxygen Species; Reproduction; Seasons; Sulfhydryl Compounds; Temperature

2004
Induction of PR-1 accumulation accompanied by runaway cell death in the lsd1 mutant of Arabidopsis is dependent on glutathione levels but independent of the redox state of glutathione.
    Plant & cell physiology, 2004, Volume: 45, Issue:11

    Topics: Arabidopsis; Arabidopsis Proteins; Buthionine Sulfoximine; Cell Death; DNA-Binding Proteins; Gene Expression Regulation, Plant; Glutathione; Glutathione Disulfide; Oxidation-Reduction; Seeds; Transcription Factors

2004
Dental adhesive compounds alter glutathione levels but not glutathione redox balance in human THP-1 monocytic cells.
    Journal of biomedical materials research. Part B, Applied biomaterials, 2005, Volume: 73, Issue:2

    Topics: Buthionine Sulfoximine; Cell Line; Composite Resins; Dentin-Bonding Agents; Glutathione; Glutathione Disulfide; Glutathione Reductase; Humans; Methacrylates; Monocytes; Oxidation-Reduction; Oxidative Stress; Polyethylene Glycols; Polymethacrylic Acids

2005
Role of glutathione in reproductive tract secretions on mouse preimplantation embryo development.
    Biology of reproduction, 2005, Volume: 73, Issue:2

    Topics: Animals; Antimetabolites; Blastocyst; Buthionine Sulfoximine; Embryonic Development; Female; Glutathione; Glutathione Disulfide; Male; Mice; Oocytes; Pregnancy; Uterus

2005
Regulation of osteoclast differentiation by the redox-dependent modulation of nuclear import of transcription factors.
    Cell death and differentiation, 2006, Volume: 13, Issue:7

    Topics: Active Transport, Cell Nucleus; Animals; Buthionine Sulfoximine; Carrier Proteins; Cell Differentiation; Cell Line; Cell Nucleus; Cell Proliferation; Cell Survival; Female; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Immunoblotting; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microscopy, Confocal; NF-kappa B; Osteoblasts; Osteoclasts; Oxidation-Reduction; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1; Transcription Factors

2006
Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.
    Cancer research, 2006, Feb-01, Volume: 66, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Deoxyglucose; Drug Synergism; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Humans; Oxidative Stress; RNA, Messenger

2006
Direct measurement of the rate of glutathione synthesis in 1-chloro-2,4-dinitrobenzene treated human erythrocytes.
    Redox report : communications in free radical research, 2006, Volume: 11, Issue:1

    Topics: Acetylcysteine; Buthionine Sulfoximine; Dinitrochlorobenzene; Erythrocytes; Glucose; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Synthase; Glutathione Transferase; Hemolysis; Humans; Methemoglobin; Oxidation-Reduction

2006
Stimulation of colonic mucosal growth associated with oxidized redox status in rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:3

    Topics: Animals; Buthionine Sulfoximine; Colon; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; Intestinal Mucosa; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley

2007
Applications of DL-buthionine-[S,R]-sulfoximine deplete cellular glutathione and improve white spruce (Picea glauca) somatic embryo development.
    Plant cell reports, 2007, Volume: 26, Issue:4

    Topics: Buthionine Sulfoximine; Cells, Cultured; Glutathione; Glutathione Disulfide; Glutathione Reductase; Microscopy; Oxidation-Reduction; Picea; Seeds

2007
The interaction of chromium (VI) with macrophages: depletion of glutathione and inhibition of glutathione reductase.
    Toxicology, 2007, Jul-01, Volume: 236, Issue:1-2

    Topics: Animals; Buthionine Sulfoximine; Carmustine; Catalase; Cell Line; Cell Survival; Chromium; Glutathione; Glutathione Disulfide; Glutathione Reductase; Macrophages; Mice; Superoxide Dismutase

2007
Manipulation of energy and redox states in the C6 glioma cells by buthionine sulfoxamine and N-acetylcysteine and the effect on cell survival to cadmium toxicity.
    Cellular and molecular biology (Noisy-le-Grand, France), 2007, Apr-15, Volume: 53, Issue:1

    Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cadmium; Cell Line, Tumor; Cell Survival; Energy Metabolism; Glutathione; Glutathione Disulfide; Humans; Oxidation-Reduction; Rats

2007
Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.
    Biochemistry, 2007, Jul-03, Volume: 46, Issue:26

    Topics: Acetylcysteine; Amino Acid Sequence; Binding Sites; Buthionine Sulfoximine; Camptothecin; Cell Line, Tumor; Cross-Linking Reagents; Cysteine; Diamide; DNA Damage; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutaral; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; Models, Molecular; Oxidative Stress; Phosphorylation; Recombinant Proteins; Tandem Mass Spectrometry; tert-Butylhydroperoxide; Tumor Suppressor Protein p53

2007
GSH loss per se does not affect neuroblastoma survival and is not genotoxic.
    International journal of oncology, 2008, Volume: 32, Issue:1

    Topics: Buthionine Sulfoximine; Cell Line, Tumor; Glutathione; Glutathione Disulfide; Heme Oxygenase-1; Humans; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Reactive Oxygen Species

2008
Oxidative stress and sodium methyldithiocarbamate-induced modulation of the macrophage response to lipopolysaccharide in vivo.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 109, Issue:2

    Topics: Analysis of Variance; Animals; Buthionine Sulfoximine; Cytokines; Female; Gene Expression Regulation; Glutathione; Glutathione Disulfide; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Pesticides; Thiocarbamates

2009
Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation.
    Free radical biology & medicine, 2009, Jul-15, Volume: 47, Issue:2

    Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Drug Synergism; Glutathione; Glutathione Disulfide; Glutathione Reductase; Humans; Oxidative Stress; Radiation Tolerance; Sulfhydryl Compounds; Thiocarbamates; X-Rays

2009
The redox state of the glutathione/glutathione disulfide couple mediates intracellular arginase activation in HCT-116 colon cancer cells.
    Digestive diseases and sciences, 2010, Volume: 55, Issue:9

    Topics: Arginase; Buthionine Sulfoximine; Colonic Neoplasms; Diamide; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; HCT116 Cells; Humans; Oxidants; Oxidation-Reduction; Oxidative Stress; Time Factors; Tumor Necrosis Factor-alpha

2010
The role of intracellular glutathione in the progression of Chlamydia trachomatis infection.
    Free radical biology & medicine, 2010, Dec-15, Volume: 49, Issue:12

    Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Survival; Chlamydia Infections; Chlamydia trachomatis; Glutathione; Glutathione Disulfide; HeLa Cells; Humans; Hydrogen Peroxide; Inclusion Bodies; Proteome

2010
Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty.
    Journal of physiology and biochemistry, 2011, Volume: 67, Issue:1

    Topics: Angioplasty, Balloon; Animals; Arteries; Atherosclerosis; Buthionine Sulfoximine; Cell Proliferation; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Hyperplasia; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Rabbits; Taurine; Telomere; Tunica Intima; Vascular System Injuries

2011
Imaging in real-time with FRET the redox response of tumorigenic cells to glutathione perturbations in a microscale flow.
    Integrative biology : quantitative biosciences from nano to macro, 2011, Volume: 3, Issue:3

    Topics: Animals; Bacterial Proteins; Biosensing Techniques; Buthionine Sulfoximine; Carmustine; Cell Line, Transformed; Cell Tracking; CHO Cells; Cricetinae; Cricetulus; Diamide; Fibroblasts; Fluorescence Resonance Energy Transfer; Glutathione; Glutathione Disulfide; Green Fluorescent Proteins; Kinetics; Luminescent Proteins; Microfluidic Analytical Techniques; Microscopy, Confocal; Microscopy, Fluorescence; Oxidation-Reduction; Oxidative Stress; Recombinant Proteins; Swine; Transfection

2011
A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: modulation by glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium.
    Cellular immunology, 2011, Volume: 270, Issue:1

    Topics: Acetylcysteine; Alveolar Epithelial Cells; Buthionine Sulfoximine; Cells, Cultured; Enzyme Activation; Glutamate-Cysteine Ligase; Glutathione Disulfide; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; MAP Kinase Signaling System; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Alveoli; Pyridines; Tumor Necrosis Factor-alpha

2011
Oxidative state and IL-6 production in intestinal myofibroblasts of Crohn's disease patients.
    Inflammatory bowel diseases, 2011, Volume: 17, Issue:8

    Topics: Acetylcysteine; Adult; Buthionine Sulfoximine; Cell Line; Colon; Crohn Disease; Female; Glutathione; Glutathione Disulfide; Humans; Ileum; Interleukin-6; Lipopolysaccharides; Male; Middle Aged; Mitogen-Activated Protein Kinase 3; Myofibroblasts; N-Formylmethionine Leucyl-Phenylalanine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Tumor Necrosis Factor-alpha

2011
Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.
    Free radical biology & medicine, 2012, Jan-15, Volume: 52, Issue:2

    Topics: Antineoplastic Agents; Auranofin; Benzoquinones; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Deoxyglucose; Drug Synergism; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Humans; Lactams, Macrocyclic; Oxidation-Reduction; Oxidative Stress; Thioredoxin-Disulfide Reductase; Thioredoxins

2012
Role of GSH/GSSG redox couple in osteogenic activity and osteoclastogenic markers of human osteoblast-like SaOS-2 cells.
    The FEBS journal, 2013, Volume: 280, Issue:3

    Topics: Acetylcysteine; Biomarkers, Tumor; Blotting, Western; Buthionine Sulfoximine; Cell Differentiation; Cell Line, Tumor; Core Binding Factor Alpha 1 Subunit; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Humans; Osteoblasts; Osteoclasts; Osteogenesis; Osteoprotegerin; Oxidation-Reduction; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction

2013
Role of N-acetylcysteine and GSH redox system on total and active MMP-2 in intestinal myofibroblasts of Crohn's disease patients.
    International journal of colorectal disease, 2013, Volume: 28, Issue:7

    Topics: Acetylcysteine; Adult; Buthionine Sulfoximine; Crohn Disease; Enzyme Activation; Glutathione; Glutathione Disulfide; Humans; Intestines; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 2; Middle Aged; Mitogen-Activated Protein Kinases; Myofibroblasts; Oxidation-Reduction; Phosphorylation; Protein Kinase Inhibitors; Tumor Necrosis Factor-alpha; Young Adult

2013
Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems.
    Molecular & cellular proteomics : MCP, 2013, Volume: 12, Issue:11

    Topics: Antioxidants; Auranofin; Buthionine Sulfoximine; Cysteine; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; HT29 Cells; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Proteome; Proteomics; Signal Transduction; Thioredoxin-Disulfide Reductase; Thioredoxins

2013
Inhibition of glutathione synthesis distinctly alters mitochondrial and cytosolic redox poise.
    Experimental biology and medicine (Maywood, N.J.), 2014, Volume: 239, Issue:4

    Topics: Animals; Buthionine Sulfoximine; Cell Line; CHO Cells; Cricetulus; Cytosol; Diamide; Enzyme Inhibitors; Glutaredoxins; Glutathione; Glutathione Disulfide; Green Fluorescent Proteins; HEK293 Cells; Humans; Mice; Mitochondria; Oxidation-Reduction; Oxidative Stress

2014
Changes in biosynthesis and metabolism of glutathione upon ochratoxin A stress in Arabidopsis thaliana.
    Plant physiology and biochemistry : PPB, 2014, Volume: 79

    Topics: Arabidopsis; Buthionine Sulfoximine; Glutathione; Glutathione Disulfide; Ochratoxins; Oxidation-Reduction; Oxidative Stress

2014
Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake.
    The Journal of biological chemistry, 2015, Sep-04, Volume: 290, Issue:36

    Topics: Acetylcysteine; Animals; Antimetabolites; Blotting, Western; Buthionine Sulfoximine; CD36 Antigens; Cell Line; Free Radical Scavengers; Gene Expression; Glutathione; Glutathione Disulfide; Lipoproteins, LDL; Macrophages; Mice, Inbred C57BL; Mice, Knockout; PPAR gamma; Protein Biosynthesis; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference

2015
A Low Glutathione Redox State Couples with a Decreased Ascorbate Redox Ratio to Accelerate Flowering in Oncidium Orchid.
    Plant & cell physiology, 2016, Volume: 57, Issue:2

    Topics: Ascorbic Acid; Buthionine Sulfoximine; Down-Regulation; Flowers; Genes, Plant; Glutathione; Glutathione Disulfide; Glutathione Reductase; Homeostasis; Models, Biological; Orchidaceae; Oxidation-Reduction; Regeneration; Temperature; Transcription, Genetic

2016
Glutamine starvation inhibits snakehead vesiculovirus replication via inducing autophagy associated with the disturbance of endogenous glutathione pool.
    Fish & shellfish immunology, 2019, Volume: 86

    Topics: Animals; Autophagy; Buthionine Sulfoximine; Cell Line; Glutamine; Glutathione; Glutathione Disulfide; Perciformes; Rhabdoviridae Infections; Vesiculovirus; Virus Replication

2019