bupropion and ritonavir

bupropion has been researched along with ritonavir in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (43.75)29.6817
2010's9 (56.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Blanco, R; Coles, R; Kharasch, ED; Mitchell, D1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Greenblatt, DJ; Hesse, LM; Shader, RI; von Moltke, LL1
Antoniou, T; Park-Wyllie, LY1
Court, MH; Greenblatt, DJ; Hesse, LM; von Moltke, LL1
Hogeland, GW; Kashuba, AD; Lindley, CM; McNabb, JC; Swindells, S; Yee, GC1
Ascher, J; Brittain, C; Iavarone, L; McConn, DJ; Muir, KT; Park, J; Sutherland, SM; Vousden, M1
Ancrenaz, V; Bosilkovska, M; Daali, Y; Dayer, P; Desmeules, J1
Collier, AC; Kharasch, ED; Kirby, BJ; Thummel, KE; Unadkat, JD; Whittington, D1

Reviews

1 review(s) available for bupropion and ritonavir

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

3 trial(s) available for bupropion and ritonavir

ArticleYear
Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bupropion; Cross-Over Studies; Cytochrome P-450 CYP2B6; Female; HIV Protease Inhibitors; Humans; Liver; Male; Oxidoreductases, N-Demethylating; Ritonavir

2008
Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:5

    Topics: Adult; Antidepressive Agents, Second-Generation; Antiviral Agents; Bupropion; Cross-Over Studies; Drug Interactions; Humans; Male; Ritonavir

2006
Lopinavir/ritonavir reduces bupropion plasma concentrations in healthy subjects.
    Clinical pharmacology and therapeutics, 2007, Volume: 81, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Bupropion; Drug Antagonism; Drug Combinations; Female; Half-Life; HIV Protease Inhibitors; Humans; Lopinavir; Male; Metabolic Clearance Rate; Pyrimidinones; Ritonavir

2007

Other Studies

12 other study(ies) available for bupropion and ritonavir

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Species independence in brain tissue binding using brain homogenates.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:2

    Topics: Alkynes; Anti-HIV Agents; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Bupropion; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; HIV Protease Inhibitors; Humans; Hydroxylation; Inhibitory Concentration 50; Microsomes, Liver; Nelfinavir; Oxazines; Oxidoreductases, N-Demethylating; Reverse Transcriptase Inhibitors; Ritonavir

2001
Concurrent use of bupropion with CYP2B6 inhibitors, nelfinavir, ritonavir and efavirenz: a case series.
    AIDS (London, England), 2003, Mar-07, Volume: 17, Issue:4

    Topics: Adult; Aged; Alkynes; Anti-HIV Agents; Antidepressive Agents, Second-Generation; Benzoxazines; Bupropion; Cyclopropanes; Drug Therapy, Combination; HIV Infections; Humans; Male; Middle Aged; Nelfinavir; Oxazines; Retrospective Studies; Ritonavir; Seizures

2003
Dose-related reduction in bupropion plasma concentrations by ritonavir.
    Journal of clinical pharmacology, 2010, Volume: 50, Issue:10

    Topics: Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Bupropion; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; HIV Protease Inhibitors; Humans; Male; Middle Aged; Ritonavir

2010
Ritonavir inhibits the two main prasugrel bioactivation pathways in vitro: a potential drug-drug interaction in HIV patients.
    Metabolism: clinical and experimental, 2011, Volume: 60, Issue:11

    Topics: Bupropion; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; HIV Infections; HIV Protease Inhibitors; Humans; In Vitro Techniques; Inactivation, Metabolic; Metabolic Networks and Pathways; Microsomes, Liver; Models, Biological; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ritonavir; Thiophenes

2011
Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:3

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; Bupropion; Digoxin; Drug Administration Schedule; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Male; Nelfinavir; Rifampin; Ritonavir

2012