bupropion has been researched along with radafaxine in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 19 (57.58) | 29.6817 |
| 2010's | 14 (42.42) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blough, BE; Carroll, FI; Damaj, MI; Eaton, JB; Huang, X; Lukas, RJ; Marxer-Miller, SK; Mascarella, SW; Muresan, AZ; Navarro, HA | 1 |
| Almond, MK; Dhillon, S; Worrall, SP | 1 |
| Carter, P; Ding, YS; Fowler, JS; Gatley, JS; Jayne, M; Learned-Coughlin, S; Logan, J; Pappas, N; Schlyer, D; Schueller, M; Shea, C; Volkow, ND; Wang, GJ; Warner, D; Wong, C; Xu, Y; Yang, J; Zhu, W | 1 |
| Gross, AS; Loboz, KK; McLachlan, AJ; Ray, J | 1 |
| Court, MH; Greenblatt, DJ; Hesse, LM; von Moltke, LL | 1 |
| Crooks, PA; Hamad, MO; Kiptoo, PK; Stinchcomb, AL | 2 |
| Astuccio, AV; Obach, RS; Walsky, RL | 1 |
| Gross, AS; Loboz, KK; McLachlan, AJ; Xu, H | 1 |
| Hogeland, GW; Kashuba, AD; Lindley, CM; McNabb, JC; Swindells, S; Yee, GC | 1 |
| Coles, R; Kharasch, ED | 2 |
| Chang, SY; Marathe, PH; Rodrigues, DA; Vuppugalla, R; Zhang, H | 1 |
| Ernest, CS; Farid, NA; Li, YG; Payne, CD; Salazar, DE; Small, DS; Winters, KJ | 1 |
| Blanco, R; Coles, R; Kharasch, ED; Mitchell, D | 1 |
| Crooks, PA; Hamad, MO; Hammell, DC; Kiptoo, PK; Paudel, KS; Stinchcomb, AL | 1 |
| Chen, J; Crooks, PA; Hammell, DC; Kiptoo, PK; Paudel, KS; Pinninti, RR; Stinchcomb, AL | 1 |
| Alfaro, RM; Formentini, E; Maldarelli, F; Natarajan, V; Penzak, SR; Robertson, SM | 1 |
| Chen, Y; Fan, L; Hu, DL; Jiang, F; Lei, HP; Li, Q; Tan, ZR; Wang, D; Wang, G; Wang, JC; Zhang, W; Zhou, HH | 1 |
| Chen, H; Hu, DL; Ji, W; Lei, HP; Lin, J; Liu, LJ; Tan, ZR; Zhou, HH | 1 |
| Chen, Y; Dai, LL; Fan, L; Lei, HP; Li, HH; Xie, HT; Yu, XY; Zhou, HH | 1 |
| Brouwer, KR; Falk, RJ; Frye, RF; Joy, MS; Kharasch, ED; Stubbert, K | 1 |
| Chen, Y; Fretland, AJ; Jones, EB; Liu, HF; Liu, L; Nguyen, K | 1 |
| Charlier, C; Denooz, R; Lachâtre, G; Mercerolle, M | 1 |
| Bae, SK; Kim, H; Kim, HS; Liu, KH; Park, SJ; Shim, EJ; Shin, JG; Shon, JH | 1 |
| Cho, JY; Chung, JY; Jang, IJ; Kim, JR; Lim, HS; Lim, KS; Shin, SG; Yu, KS | 1 |
| Doğrukol-Ak, D; Korkmaz, OT; Sener, E; Tuncel, N; Yeniceli, D | 1 |
| Blough, BE; Carroll, FI; Damaj, MI; Eaton, JB; Huang, X; Lukas, RJ; Mascarella, SW; Muresan, AZ; Navarro, HA | 1 |
| Hansard, MJ; Jackson, MJ; Jenner, P; Rose, S; Smith, LA | 1 |
| Parekh, JM; Sanyal, M; Shrivastav, PS; Sutariya, DK; Vaghela, RN; Yadav, M | 1 |
| Amdo, TD; Chowdhury, F; Feng, Q; Hoffman, RS; Livshits, Z; Nelson, LS | 1 |
| Hassan, HE; Molnari, JC; Myers, AL | 1 |
| Hu, L; Ma, J; Wang, X; Wang, Z; Xu, R; Zhang, X | 1 |
6 trial(s) available for bupropion and radafaxine
| Article | Year |
|---|---|
The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects.
Topics: Adult; Antidepressive Agents; Blood Pressure; Brain; Brain Mapping; Bupropion; Cocaine; Dopamine Plasma Membrane Transport Proteins; Heart Rate; Humans; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Positron-Emission Tomography; Reinforcement, Psychology; Statistics, Nonparametric; Time Factors; Tritium | 2005 |
Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers.
Topics: Adult; Antidepressive Agents, Second-Generation; Antiviral Agents; Bupropion; Cross-Over Studies; Drug Interactions; Humans; Male; Ritonavir | 2006 |
Lopinavir/ritonavir reduces bupropion plasma concentrations in healthy subjects.
Topics: Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Bupropion; Drug Antagonism; Drug Combinations; Female; Half-Life; HIV Protease Inhibitors; Humans; Lopinavir; Male; Metabolic Clearance Rate; Pyrimidinones; Ritonavir | 2007 |
Prasugrel, a new thienopyridine antiplatelet drug, weakly inhibits cytochrome P450 2B6 in humans.
Topics: Adolescent; Adult; Area Under Curve; Bupropion; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Delayed-Action Preparations; Drug Interactions; Half-Life; Humans; Male; Middle Aged; Molecular Structure; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Pyridines; Tandem Mass Spectrometry; Thiophenes; Time Factors | 2008 |
Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bupropion; Cross-Over Studies; Cytochrome P-450 CYP2B6; Female; HIV Protease Inhibitors; Humans; Liver; Male; Oxidoreductases, N-Demethylating; Ritonavir | 2008 |
Effects of woohwangcheongsimwon suspension on the pharmacokinetics of bupropion and its active metabolite, 4-hydroxybupropion, in healthy subjects.
Topics: Adult; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Bupropion; Cross-Over Studies; Cytochrome P-450 CYP2B6; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Male; Middle Aged; Oxidoreductases, N-Demethylating; Suspensions; Young Adult | 2010 |
27 other study(ies) available for bupropion and radafaxine
| Article | Year |
|---|---|
Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Body Temperature; Bupropion; Cell Line; Dopamine Uptake Inhibitors; Humans; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Selective Serotonin Reuptake Inhibitors; Smoking Cessation; Stereoisomerism; Structure-Activity Relationship | 2010 |
Pharmacokinetics of bupropion and its metabolites in haemodialysis patients who smoke. A single dose study.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Biotransformation; Bupropion; Cohort Studies; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Female; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Oxidoreductases, N-Demethylating; Renal Dialysis; Smoking; Smoking Cessation | 2004 |
HPLC assay for bupropion and its major metabolites in human plasma.
Topics: Area Under Curve; Bupropion; Chromatography, High Pressure Liquid; Half-Life; Humans; Reproducibility of Results | 2005 |
Enhancement of transdermal delivery of 6-beta-naltrexol via a codrug linked to hydroxybupropion.
Topics: Administration, Cutaneous; Bupropion; Drug Carriers; Drug Delivery Systems; Drug Synergism; Humans; In Vitro Techniques; Naltrexone; Skin Absorption | 2006 |
Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents.
Topics: Alcohol Deterrents; Bupropion; Drug Stability; Hydrolysis; Molecular Structure; Naltrexone; Smoking Cessation; Stereoisomerism; Structure-Activity Relationship; Time Factors | 2006 |
Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6.
Topics: Algorithms; Alkynes; Antidepressive Agents, Second-Generation; Antifungal Agents; Area Under Curve; Benzoxazines; Bupropion; Clopidogrel; Clotrimazole; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Itraconazole; Kinetics; Microsomes, Liver; Molecular Structure; Oxazines; Platelet Aggregation Inhibitors; Raloxifene Hydrochloride; Reverse Transcriptase Inhibitors; Selective Estrogen Receptor Modulators; Selective Serotonin Reuptake Inhibitors; Sertraline; Ticlopidine; Xenobiotics | 2006 |
Stereoselective analysis of hydroxybupropion and application to drug interaction studies.
Topics: Antibiotics, Antitubercular; Antidepressive Agents, Second-Generation; Bupropion; Chromatography, High Pressure Liquid; Humans; Male; Rifampin; Stereoisomerism | 2007 |
Stereoselective analysis of bupropion and hydroxybupropion in human plasma and urine by LC/MS/MS.
Topics: Antidepressive Agents, Second-Generation; Bupropion; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Tandem Mass Spectrometry | 2007 |
Effect of commonly used organic solvents on the kinetics of cytochrome P450 2B6- and 2C8-dependent activity in human liver microsomes.
Topics: Acetonitriles; Aryl Hydrocarbon Hydroxylases; Bupropion; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C8; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Ethanol; Humans; Hydroxylation; Kinetics; Methanol; Microsomes, Liver; Paclitaxel; Solvents; Taxoids | 2007 |
Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes.
Topics: Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bupropion; Cytochrome P-450 CYP2B6; Humans; Microsomes, Liver; Oxidoreductases, N-Demethylating; Stereoisomerism | 2008 |
In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs.
Topics: Administration, Cutaneous; Alcohol-Related Disorders; Animals; Bupropion; Chromatography, High Pressure Liquid; Drug Delivery Systems; Female; Guinea Pigs; Male; Mass Spectrometry; Molecular Structure; Naltrexone; Prodrugs; Skin; Skin Absorption; Skin Irritancy Tests; Smoking Cessation | 2008 |
Transdermal delivery of bupropion and its active metabolite, hydroxybupropion: a prodrug strategy as an alternative approach.
Topics: Administration, Cutaneous; Animals; Bupropion; Carbamates; Diffusion; Diffusion Chambers, Culture; Dopamine Uptake Inhibitors; Drug Stability; Female; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Male; Models, Biological; Prodrugs; Skin; Skin Absorption; Solubility | 2009 |
Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects.
Topics: Adult; Alkynes; Anti-HIV Agents; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Bupropion; Cyclopropanes; Cytochrome P-450 CYP2B6; Delayed-Action Preparations; Drug Interactions; Enzyme Induction; Female; Genetic Variation; Humans; Hydroxylation; Male; Middle Aged; Oxidoreductases, N-Demethylating; Pharmacogenetics; Young Adult | 2008 |
Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bupropion; Cytochrome P-450 CYP2B6; Dopamine Uptake Inhibitors; Enzyme Induction; Flavonoids; Glucuronidase; Haplotypes; Herb-Drug Interactions; Humans; Hydroxylation; Male; Oxidoreductases, N-Demethylating; Plant Extracts; Polymorphism, Single Nucleotide; Time Factors | 2009 |
Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers.
Topics: Administration, Oral; Adult; Antidepressive Agents; Bupropion; Chromatography, High Pressure Liquid; Epidemiologic Methods; Ginkgo biloba; Herb-Drug Interactions; Humans; Male; Plant Extracts; Young Adult | 2009 |
Effect of St. John's wort supplementation on the pharmacokinetics of bupropion in healthy male Chinese volunteers.
Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Chromatography, High Pressure Liquid; Half-Life; Humans; Hypericum; Male; Plant Preparations; Tandem Mass Spectrometry | 2010 |
Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.
Topics: Adult; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Bupropion; Chronic Disease; Cytochrome P-450 CYP2B6; Female; Humans; Lupus Nephritis; Male; Middle Aged; Oxidoreductases, N-Demethylating; Phenotype; Stereoisomerism | 2010 |
The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19.
Topics: Aryl Hydrocarbon Hydroxylases; Bupropion; Cytochrome P-450 CYP2C19; DNA, Complementary; Humans; Hydroxylation; Microsomes, Liver | 2010 |
Ultra-performance liquid chromatography- tandem mass spectrometry method for the determination of bupropion and its main metabolites in human whole blood.
Topics: Bupropion; Chromatography, High Pressure Liquid; Humans; Tandem Mass Spectrometry | 2010 |
Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin.
Topics: Aryl Hydrocarbon Hydroxylases; Asian People; Bupropion; Cytochrome P-450 CYP2B6; Drug Interactions; Female; Genotype; Humans; Hydroxylation; Male; Oxidoreductases, N-Demethylating; Polymorphism, Single Nucleotide; Pregnane X Receptor; Receptors, Steroid; Rifampin | 2011 |
A simple and sensitive LC-ESI-MS (ion trap) method for the determination of bupropion and its major metabolite, hydroxybupropion in rat plasma and brain microdialysates.
Topics: Animals; Blood Chemical Analysis; Brain; Bupropion; Chromatography, Liquid; Linear Models; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2011 |
Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Biogenic Monoamines; Body Temperature; Bupropion; Conditioning, Psychological; Dopamine; Dopamine Uptake Inhibitors; HEK293 Cells; Humans; Male; Mice; Mice, Inbred ICR; Morpholines; Motor Activity; Nicotine; Nicotinic Antagonists; Norepinephrine; Receptors, Nicotinic; Serotonin; Smoking Cessation; Stereoisomerism; Structure-Activity Relationship | 2011 |
A major metabolite of bupropion reverses motor deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets.
Topics: Animals; Bupropion; Callithrix; Dose-Response Relationship, Drug; Female; Levodopa; Male; Motor Activity; MPTP Poisoning; Stereoisomerism | 2011 |
Sensitive, selective and rapid determination of bupropion and its major active metabolite, hydroxybupropion, in human plasma by LC-MS/MS: application to a bioequivalence study in healthy Indian subjects.
Topics: Antidepressive Agents, Second-Generation; Bupropion; Chromatography, Liquid; Humans; India; Limit of Detection; Quality Control; Reference Standards; Reference Values; Tandem Mass Spectrometry; Therapeutic Equivalency | 2012 |
Life-threatening bupropion ingestion: is there a role for intravenous fat emulsion?
Topics: Antidotes; Bupropion; Eating; Electrocardiography; Fat Emulsions, Intravenous; Female; Humans; Hypotension; Middle Aged; Sodium Bicarbonate; Tachycardia, Ventricular | 2011 |
Effects of sertraline on the pharmacokinetics of bupropion and its major metabolite, hydroxybupropion, in mice.
Topics: Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Brain; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Drug Interactions; Enzyme Inhibitors; Male; Mice; Oxidoreductases, N-Demethylating; Selective Serotonin Reuptake Inhibitors; Sertraline; Tissue Distribution | 2012 |
Determination of bupropion and its main metabolite in rat plasma by LC-MS and its application to pharmacokinetics.
Topics: Animals; Antidepressive Agents, Second-Generation; Area Under Curve; Bupropion; Calibration; Chromatography, High Pressure Liquid; Half-Life; Indicators and Reagents; Male; Quality Control; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2011 |