bupropion has been researched along with dextromethorphan in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 14 (45.16) | 2.80 |
| Authors | Studies |
|---|---|
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Dalvie, D; Loi, CM; Smith, DA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Glick, SD; Maisonneuve, IM; Panchal, V; Taraschenko, OD | 1 |
| Adson, DE; Brauer, LH; Bronars, CA; Harris, J; Hatsukami, DK; Kotlyar, M; Tracy, TS | 1 |
| Greenblatt, DJ; Leigh-Pemberton, RA; von Moltke, LL | 1 |
| Arellano, C; Belkhelfa, H; Bonnefille, P; Gandia, P; Houin, G; Sezgin-Bayindir, Z; Woodley, J | 1 |
| Bosilkovska, M; Daali, Y; Déglon, J; Desmeules, J; Samer, C; Staub, C; Walder, B | 1 |
| Bosilkovska, M; Daali, Y; Dayer, P; Déglon, J; Desmeules, JA; Rebsamen, M; Samer, CF; Staub, C; Walder, B | 1 |
| Bosilkovska, M; Daali, Y; Déglon, J; Desmeules, J; Samer, C; Thomas, A; Walder, B | 1 |
| Akhtar, S; Desai, A; Goldwater, R; Han, D; Howieson, C; Kowalski, D; Lademacher, C; Pearlman, H; Rammelsberg, D; Townsend, R; Yamazaki, T | 1 |
| Chiasson, JL; Grangeon, A; Gravel, S; Michaud, V; Turgeon, J | 1 |
| Stahl, SM | 1 |
| Blair, G; Davis, JM; Ko, A; Levin, ED; Modarres, J; Pace, C; Rezvani, AH; Rose, JE; Wells, C | 1 |
| Cao, B; Ho, R; Majeed, A; McIntyre, RS; Ng, J; Phan, L; Rosenblat, JD; Teopiz, KM; Xiong, J | 1 |
| Brantley, SJ; Dai, X; Goulet, MT; Hard, ML; Hitron, M; Karol, MD; McLaughlin, CF | 1 |
| Anderson, A; Iosifescu, DV; Jacobson, M; Jones, A; Tabuteau, H | 1 |
| Fava, M; Feliz, S; Iosifescu, DV; Jones, A; O'Gorman, C; Streicher, C; Tabuteau, H | 1 |
| Schatzberg, AF | 1 |
| Keam, SJ | 1 |
| Abuzoor, A; Busse, K; El-Alfy, AT | 1 |
| Iosifescu, DV; Parincu, Z | 1 |
| Aschenbrenner, DS | 1 |
| Bertels, K; Fredrickson, C; Lothet, E; Mullins, ME; Nguyen, KL | 1 |
| Akbar, D; Cao, B; Ceban, F; Ho, R; Kwan, ATH; McIntyre, RS; Rhee, TG; Rosenblat, JD; Subramaniapillai, M; Teopiz, KM | 1 |
6 review(s) available for bupropion and dextromethorphan
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Dextromethorphan/Bupropion: A Novel Oral NMDA (N-methyl-d-aspartate) Receptor Antagonist with Multimodal Activity.
Topics: Administration, Oral; Animals; Antidepressive Agents, Second-Generation; Bupropion; Dextromethorphan; Dopamine; Humans; Norepinephrine; Receptors, N-Methyl-D-Aspartate | 2019 |
Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials.
Topics: Adult; Animals; Antidepressive Agents; Bipolar Disorder; Bupropion; Depressive Disorder, Major; Dextromethorphan; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Humans; Molecular Targeted Therapy | 2021 |
Dextromethorphan/Bupropion: First Approval.
Topics: Adult; Antidepressive Agents; Bupropion; Depressive Disorder, Major; Dextromethorphan; Drug Approval; Humans; Receptors, N-Methyl-D-Aspartate | 2022 |
Combinations of dextromethorphan for the treatment of mood disorders - a review of the evidence.
Topics: Adult; Bipolar Disorder; Bupropion; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Dextromethorphan; Humans; Mood Disorders | 2023 |
Dextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials.
Topics: Adult; Antidepressive Agents; Bupropion; Depression; Depressive Disorder, Major; Dextromethorphan; Humans | 2023 |
6 trial(s) available for bupropion and dextromethorphan
| Article | Year |
|---|---|
Inhibition of CYP2D6 activity by bupropion.
Topics: Adult; Bupropion; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Middle Aged | 2005 |
Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method.
Topics: Adolescent; Adult; Bupropion; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Dried Blood Spot Testing; Drug Interactions; Female; Flurbiprofen; Genotyping Techniques; Humans; Male; Midazolam; Omeprazole; Phenotype; Terfenadine; Young Adult | 2016 |
Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects.
Topics: Adult; Area Under Curve; Bupropion; Caffeine; Carbamates; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Methadone; Middle Aged; Nitriles; Piperidines; Pyridines; Triazoles; Young Adult | 2017 |
Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers.
Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzofurans; Bupropion; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Flurbiprofen; Gene Expression Regulation; Half-Life; Healthy Volunteers; Humans; Male; Midazolam; Naphthoquinones; Neoplasm Proteins; Omeprazole; Rosuvastatin Calcium; Young Adult | 2021 |
Effect of AXS-05 (Dextromethorphan-Bupropion) in Major Depressive Disorder: A Randomized Double-Blind Controlled Trial.
Topics: Adolescent; Adult; Aged; Bupropion; Depressive Disorder, Major; Dextromethorphan; Double-Blind Method; Humans; Middle Aged; Treatment Outcome; Young Adult | 2022 |
Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder: A Phase 3 Randomized Clinical Trial (GEMINI).
Topics: Bupropion; Depressive Disorder, Major; Dextromethorphan; Double-Blind Method; Humans; Quality of Life | 2022 |
19 other study(ies) available for bupropion and dextromethorphan
| Article | Year |
|---|---|
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
Is antagonism of alpha3beta4 nicotinic receptors a strategy to reduce morphine dependence?
Topics: Acute Disease; Animals; Bupropion; Dextromethorphan; Drug Therapy, Combination; Female; Mecamylamine; Morphine Dependence; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substance Withdrawal Syndrome | 2005 |
In vitro interactions of water-soluble garlic components with human cytochromes p450.
Topics: Bupropion; Cytochrome P-450 Enzyme System; Dextromethorphan; Flurbiprofen; Garlic; Humans; Isoenzymes; Kinetics; Phenacetin; Plant Extracts; Triazolam | 2006 |
The use of isolated enterocytes to study Phase I intestinal drug metabolism: validation with rat and pig intestine.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Bupropion; Chromatography, Liquid; Dextromethorphan; Enterocytes; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Isoenzymes; L-Lactate Dehydrogenase; Male; Mass Spectrometry; Microsomes; Midazolam; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Swine | 2011 |
Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Calibration; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Flurbiprofen; Half-Life; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine | 2014 |
Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots.
Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Capsules; Carbonated Beverages; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coffee; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Enzyme Inhibitors; Feasibility Studies; Flurbiprofen; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Phenotype; Pilot Projects; Predictive Value of Tests; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine; Young Adult | 2014 |
Modulation of CYP450 Activities in Patients With Type 2 Diabetes.
Topics: Adult; Aged; Bupropion; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diabetes Mellitus, Type 2; Female; Humans; Interferon-gamma; Interleukin-1beta; Interleukin-6; Male; Midazolam; Middle Aged; Omeprazole; Tolbutamide; Tumor Necrosis Factor-alpha | 2019 |
Dextromethorphan and bupropion reduces high level remifentanil self-administration in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bupropion; Dextromethorphan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Locomotion; Motivation; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Remifentanil; Self Administration; Treatment Outcome | 2020 |
Understanding the Efficacy and Mechanism of Action of a Dextromethorphan-Bupropion Combination: Where Does It Fit in the NMDA Versus mu-Opioid Story?
Topics: Analgesics, Opioid; Bupropion; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate | 2022 |
Dextromethorphan Hydrobromide and Bupropion Hydrochloride.
Topics: Bupropion; Chromatography, High Pressure Liquid; Dextromethorphan; Humans | 2022 |
Dextromethorphan/bupropion (Auvelity) for depression.
Topics: Bupropion; Depression; Dextromethorphan; Humans; Selective Serotonin Reuptake Inhibitors; Smoking Cessation | 2022 |
Auvelity (dextromethorphan/bupropion).
Topics: Bupropion; Dextromethorphan; Humans | 2023 |
New Combination Drug for Depression.
Topics: Antidepressive Agents; Bupropion; Child; Depressive Disorder, Major; Dextromethorphan; Drug Combinations; Female; Humans; Male; Young Adult | 2023 |
Intentional overdose of a novel dextromethorphan-bupropion combination antidepressant.
Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Bupropion; Dextromethorphan; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2023 |