bupropion has been researched along with bw 306u in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.13) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 26 (81.25) | 24.3611 |
| 2020's | 5 (15.63) | 2.80 |
| Authors | Studies |
|---|---|
| De Vane, CL; Golden, RN; Laizure, SC; Potter, WZ; Rudorfer, MV; Sherer, MA | 1 |
| Carroll, FI; Damaj, MI; Grabus, SD | 1 |
| Chen, X; Gao, L; He, Y; Huang, Z; Liu, F; Liu, Z; Ouyang, D; Tang, J; Yin, J; Zhang, W; Zhou, H | 1 |
| Al-Abri, SA; Benowitz, NL; Hayashi, S; Olson, KR; Orengo, JP; Thoren, KL | 1 |
| Chen, X; He, J; Prasad, B; Unadkat, JD; Yu, Y | 1 |
| Brünen, S; Hiemke, C; Laib, AK; Pfeifer, P; Vincent, P | 1 |
| Blough, BE; Carroll, FI; Damaj, MI; Lukas, RJ; Mascarella, SW; Navarro, HA | 1 |
| Dinger, J; Maurer, HH; Meyer, MR | 1 |
| Clarke, W; Jannetto, PJ; Johnson-Davis, KL; Langman, LJ; Marzinke, MA; Moskowitz, J; Petrides, AK | 1 |
| Haslemo, T; Høiseth, G; Molden, E; Uthus, LH | 1 |
| Blough, B; Carroll, FI; Damaj, MI; Malcolm, E; Shoaib, M | 1 |
| Chen, L; Li, J; Tian, L; Zhang, C | 1 |
| Dai, H; Gaedigk, A; Gaedigk, R; Leeder, JS; Pearce, RE; Riffel, AK; Twist, GP | 1 |
| Cremers, TI; Flik, G; Folgering, JH; Rollema, H; Stratford, RE | 1 |
| Ahmed, MS; Clark, SM; Fokina, VM; Hankins, GD; Nanovskaya, TN; Oncken, C; West, H | 1 |
| Flaker, AM; Kharasch, ED; Teitelbaum, AM | 1 |
| Cao, SP; Cheng, L; Dai, HY; Gao, LC; Liu, FQ; Tang, J; Tao, R; Wang, D; Yang, L | 1 |
| Isoherranen, N; Price, LS; Sager, JE | 1 |
| Abdel-Rahman, SZ; Ahmed, MS; Clark, SM; Fokina, VM; Hankins, GD; Nanovskaya, TN; Oncken, C; Rytting, E; West, H; Xu, M | 1 |
| Blanton, MP; Jansen, M; Pandhare, A; Pappu, AS; Wilms, H | 1 |
| Babiskin, A; Connarn, JN; Ellingrod, VL; Harrington, G; Kamali, M; Kelly, M; Luo, R; McInnis, M; Sun, D; Windak, J; Zhang, X | 1 |
| Chen, JY; Chen, Y; Huang, XT; Wang, JJ | 1 |
| Bhatt, NM; Chavada, VD; Sanyal, M; Shrivastav, PS | 1 |
| Capron, A; De Boosere, E; Schmit, G; Vanhaebost, J | 1 |
| Dash, RP; Rais, R; Srinivas, NR | 1 |
| Dang, H; Ma, H; Ma, Y; Wei, S; Yang, X; Zhang, H; Zhang, W; Zhang, Y | 1 |
| Menke, A; Scherf-Clavel, M; Unterecker, S; Wahl, O | 1 |
| Gaebler, AJ; Paulzen, M; Schneider, KL; Stingl, JC | 1 |
| Bishop, JR; Eum, S; Lee, AM; Sayre, F; Stingl, JC | 1 |
| Ahluwalia, JS; Benowitz, NL; Chenoweth, MJ; Cox, LS; Knight, J; Nollen, NL; Peng, AR; Swardfager, W; Tyndale, RF; Zhu, AZX | 1 |
| Dinh, J; Harbeson, S; Morgan, AJ; Pelletier, R; Raccor, B; Shi, Y; Totah, RA; Uttamsingh, V; Yusuff, N | 1 |
| Bach, C; Bhattacharya, CS; Masters, AR; Sinn, AL; Stratford, RE; Trowbridge, MA | 1 |
3 review(s) available for bupropion and bw 306u
| Article | Year |
|---|---|
Bupropion and bupropion analogs as treatments for CNS disorders.
Topics: Animals; Bupropion; Central Nervous System Diseases; Humans; Protein Binding; Treatment Outcome | 2014 |
Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion.
Topics: Antidepressive Agents, Second-Generation; Biological Availability; Bupropion; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Drug Interactions; Humans; Inactivation, Metabolic; Stereoisomerism | 2018 |
Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis.
Topics: Bupropion; Cytochrome P-450 CYP2B6; Genotype; Humans; Polymorphism, Genetic | 2022 |
5 trial(s) available for bupropion and bw 306u
| Article | Year |
|---|---|
Bupropion in depression. II. The role of metabolites in clinical outcome.
Topics: Adult; Aged; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Half-Life; Humans; Male; Middle Aged; Outcome and Process Assessment, Health Care; Propiophenones | 1988 |
Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate.
Topics: Adult; Bupropion; Coumaric Acids; Cross-Over Studies; Cytochrome P-450 CYP2B6; Drug Interactions; Genetic Variation; Genotype; Humans; Hydroxylation; Male; Polymorphism, Single Nucleotide; Pregnane X Receptor; Receptors, Steroid; Young Adult | 2013 |
The P450 oxidoreductase (POR) rs2868177 and cytochrome P450 (CYP) 2B6*6 polymorphisms contribute to the interindividual variability in human CYP2B6 activity.
Topics: Adult; Area Under Curve; Asian People; Bupropion; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Gene Frequency; Genotype; Healthy Volunteers; Humans; Hydroxylation; Male; Polymorphism, Single Nucleotide; Young Adult | 2016 |
Effects of Genetic Polymorphisms of CYP2B6 on the Pharmacokinetics of Bupropion and Hydroxybupropion in Healthy Chinese Subjects.
Topics: Adolescent; Adult; Area Under Curve; Asian People; Bupropion; China; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP2B6; Genotype; Healthy Volunteers; Humans; Male; Polymorphism, Single Nucleotide; Tandem Mass Spectrometry; Young Adult | 2018 |
Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis.
Topics: Black or African American; Bupropion; Cytochrome P-450 CYP2B6; Female; Humans; Male; Mediation Analysis; Smoking Cessation | 2022 |
24 other study(ies) available for bupropion and bw 306u
| Article | Year |
|---|---|
Bupropion and its main metabolite reverse nicotine chronic tolerance in the mouse.
Topics: Analgesics; Animals; Antidepressive Agents; Body Temperature; Bupropion; Dose-Response Relationship, Drug; Drug Tolerance; Hypothermia, Induced; Male; Mice; Nicotine; Smoking Cessation | 2012 |
Delayed bupropion cardiotoxicity associated with elevated serum concentrations of bupropion but not hydroxybupropion.
Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxins; Drug Overdose; Electrocardiography; Gastrointestinal Tract; Heart Diseases; Humans; Male; Seizures; Status Epilepticus | 2013 |
Mechanism of an unusual, but clinically significant, digoxin-bupropion drug interaction.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bupropion; Cardiotonic Agents; Digoxin; Dogs; Dopamine Uptake Inhibitors; Drug Interactions; Female; Humans; Madin Darby Canine Kidney Cells; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Species Specificity | 2014 |
Serum concentrations of hydroxybupropion for dose optimization of depressed patients treated with bupropion.
Topics: Antidepressive Agents, Second-Generation; Area Under Curve; Bupropion; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Half-Life; Humans; Male; Middle Aged; Retrospective Studies | 2014 |
Development and validation of a liquid-chromatography high-resolution tandem mass spectrometry approach for quantification of nine cytochrome P450 (CYP) model substrate metabolites in an in vitro CYP inhibition cocktail.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Bupropion; Calibration; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Drug Evaluation, Preclinical; Humans; Substrate Specificity; Tandem Mass Spectrometry; Umbelliferones | 2014 |
The development and validation of a turbulent flow-liquid chromatography-tandem mass spectrometric method for the simultaneous quantification of citalopram, sertraline, bupropion and hydroxybupropion in serum.
Topics: Antidepressive Agents; Bupropion; Chromatography, Liquid; Citalopram; Drug Stability; Humans; Reproducibility of Results; Sensitivity and Specificity; Sertraline; Solid Phase Extraction; Tandem Mass Spectrometry | 2014 |
Effect of CYP2B6*6 on Steady-State Serum Concentrations of Bupropion and Hydroxybupropion in Psychiatric Patients: A Study Based on Therapeutic Drug Monitoring Data.
Topics: Adult; Bupropion; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2D6; Drug Monitoring; Female; Genotype; Humans; Male; Middle Aged; Retrospective Studies | 2015 |
Examination of the metabolite hydroxybupropion in the reinforcing and aversive stimulus effects of nicotine in rats.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Bupropion; Male; Nicotine; Rats; Receptors, Nicotinic; Reward; Self Administration; Smoking Cessation; Tobacco Use Disorder | 2015 |
Synthesis of deuterium-labeled hydroxybupropion.
Topics: Antidepressive Agents, Second-Generation; Bupropion; Deuterium | 2015 |
Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Biotransformation; Bupropion; Child; Child, Preschool; Cytochrome P-450 CYP2B6; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gene Frequency; Gestational Age; Haplotypes; Humans; Hydroxylation; Infant; Infant, Newborn; Liver; Male; Microsomes, Liver; Middle Aged; Pharmacogenetics; Pharmacogenomic Variants; RNA, Messenger; Substrate Specificity; Young Adult | 2016 |
Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations.
Topics: Animals; Blood-Brain Barrier; Brain; Bupropion; Dopamine Plasma Membrane Transport Proteins; Extracellular Fluid; Humans; Male; Microdialysis; Norepinephrine Plasma Membrane Transport Proteins; Plasma; Rats; Rats, Sprague-Dawley | 2016 |
Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid.
Topics: Adult; Amniotic Fluid; Antidepressive Agents, Second-Generation; Bupropion; Depression; Female; Fetal Blood; Fetus; Humans; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnancy Complications; Smoking Cessation | 2016 |
Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine.
Topics: Antidepressive Agents, Second-Generation; Bupropion; Chromatography, High Pressure Liquid; Glucuronides; Humans; Limit of Detection; Oxidation-Reduction; Smoking Cessation; Tandem Mass Spectrometry | 2016 |
Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4'-OH-bupropion in vitro.
Topics: Antidepressive Agents, Second-Generation; Bupropion; Humans; In Vitro Techniques; Stereoisomerism | 2016 |
Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy.
Topics: Adult; Alleles; Antidepressive Agents, Second-Generation; Bupropion; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Female; Humans; Polymorphism, Single Nucleotide; Pregnancy; Prospective Studies; Young Adult | 2016 |
The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors.
Topics: Allosteric Regulation; Animals; Antidepressive Agents, Second-Generation; Bupropion; Dose-Response Relationship, Drug; Granisetron; HEK293 Cells; Humans; Mice; Oocytes; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Xenopus laevis | 2017 |
Identification of non-reported bupropion metabolites in human plasma.
Topics: Antidepressive Agents, Second-Generation; Bupropion; Chromatography, Liquid; Humans; Spectrometry, Mass, Electrospray Ionization | 2016 |
In vivo effect of borneol on rat hepatic CYP2B expression and activity.
Topics: Administration, Oral; Animals; Bupropion; Camphanes; Cell Nucleus; Constitutive Androstane Receptor; Cytochrome P450 Family 2; Liver; Male; Microsomes, Liver; Protein Transport; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Regression Analysis; Reproducibility of Results | 2017 |
Design of experiment assisted concurrent enantioseparation of bupropion and hydroxybupropion by high-performance thin-layer chromatography.
Topics: Bupropion; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Research Design; Stereoisomerism; Tartrates | 2017 |
Bupropion Overdose Resulted in a Pharmacobezoar in a Fatal Bupropion (Wellbutrin
Topics: Adult; Antidepressive Agents, Second-Generation; Bezoars; Bile; Bupropion; Delayed-Action Preparations; Drug Overdose; Female; Humans; Kidney; Liver; Postmortem Changes; Stomach; Tablets; Tissue Distribution; Vitreous Body | 2017 |
Determination of hydroxybupropion in human serum for routine therapeutic drug monitoring in psychiatry: A tool for dose-individualization in treatment with bupropion.
Topics: Adult; Aged; Bupropion; Chromatography, High Pressure Liquid; Drug Monitoring; Female; Humans; Limit of Detection; Linear Models; Male; Middle Aged; Reproducibility of Results; Retrospective Studies; Solid Phase Extraction; Young Adult | 2019 |
Subtherapeutic bupropion and hydroxybupropion serum concentrations in a patient with CYP2C19*1/*17 genotype suggesting a rapid metabolizer status.
Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Cytochrome P-450 CYP2C19; Depressive Disorder, Major; Humans; Male | 2020 |
Selective deuteration of bupropion slows epimerization and reduces metabolism.
Topics: Bupropion; Cytochrome P-450 CYP2B6; Deuterium; Humans; Recombinant Proteins | 2022 |
Characterization of the Stereoselective Disposition of Bupropion and Its Metabolites in Rat Plasma and Brain.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Bupropion; Rats; Tandem Mass Spectrometry | 2023 |