buprenorphine has been researched along with lofentanil* in 3 studies
1 trial(s) available for buprenorphine and lofentanil
| Article | Year |
|---|---|
Efficacy of the extradural administration of lofentanil, buprenorphine or saline in the management of postoperative pain. A double-blind study.
Sixty postoperative orthopaedic patients were randomly assigned to three equal groups to study, in a double-blind fashion, the analgesic effects, durations of action and side effects of the extradural administration of lofentanil 5 micrograms, buprenorphine 0.3 mg or physiological saline. No systemic analgesics were given before, during or after surgery, and all the patients had operations on the lower extremities under extradural analgesia (lignocaine and bupivacaine). Eleven millilitre of the test drug was injected at T12-L1 as soon as pain occurred in the postoperative period. We observed a long duration of action and a marked analgesic effect with lofentanil, a shorter duration of action and less pain suppression with buprenorphine and a rather marked placebo effect after saline. The only side effect noticed in this study was drowsiness in three patients in the lofentanil group and in two patients in the buprenorphine group. Topics: Adult; Aged; Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Double-Blind Method; Epidural Space; Female; Fentanyl; Humans; Injections; Male; Middle Aged; Morphinans; Pain, Postoperative | 1985 |
2 other study(ies) available for buprenorphine and lofentanil
| Article | Year |
|---|---|
An analgesiometry system for use in rabbits with some preliminary data on the effects of buprenorphine and lofentanil.
A low cost infrared skin heating system has been designed to measure the efficacy of analgesics in rabbits. Following construction of a prototype, it was used to assess the effect of buprenorphine given subcutaneously and per rectum. Buprenorphine administered subcutaneously has a rapid onset of action, but its duration (8-10 h) appears slightly shorter than has been suggested previously; rectal administration appears to prolong its effect. Preliminary data show that lofentanil has a longer duration of action than buprenorphine and it may prove, therefore, to be a valuable long-acting analgesic in the rabbit. Topics: Analgesia; Animals; Buprenorphine; Female; Fentanyl; Injections, Subcutaneous; Kinetics; Male; Pain Measurement; Rabbits; Rectum | 1988 |
[Use of morphine derivatives by the systemic route in the treatment of acute pain].
Topics: Acute Disease; Alfentanil; Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; Infusions, Parenteral; Intraoperative Period; Pain; Postoperative Period; Sufentanil | 1985 |