buprenorphine and barium-chloride

buprenorphine has been researched along with barium-chloride* in 1 studies

Other Studies

1 other study(ies) available for buprenorphine and barium-chloride

Article	Year
Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor. Peptides, 2000, Volume: 21, Issue:7 The nociceptin/orphanin FQ (N/OFQ) receptor (e.g. the human ortholog ORL1) has been shown to be pharmacologically distinct from classic opioid receptors. Recently, we have identified buprenorphine as a full ORL1 agonist using a reporter gene assay. For further functional analysis, buprenorphine's effects on ORL1 receptors were investigated using a K(+) channel (GIRK1) assay in Xenopus oocytes and GTPgammaS assay in CHO-K1 membrane preparations. In both assays, buprenorphine behaved as a partial agonist compared to nociceptin itself. The N/OFQ agonism of buprenorphine might contribute to actions of buprenorphine in pain models in vivo beside its mu- or kappa-opioid receptor mediated effects. Topics: Analgesics, Opioid; Animals; Barium Compounds; Buprenorphine; Chlorides; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Genes, Reporter; Guanosine 5'-O-(3-Thiotriphosphate); Naloxone; Narcotic Antagonists; Nociceptin Receptor; Oocytes; Patch-Clamp Techniques; Potassium Channels; Protein Binding; Receptors, Opioid; Xenopus	2000

Article

Year

Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor.

Peptides, 2000, Volume: 21, Issue:7

The nociceptin/orphanin FQ (N/OFQ) receptor (e.g. the human ortholog ORL1) has been shown to be pharmacologically distinct from classic opioid receptors. Recently, we have identified buprenorphine as a full ORL1 agonist using a reporter gene assay. For further functional analysis, buprenorphine's effects on ORL1 receptors were investigated using a K(+) channel (GIRK1) assay in Xenopus oocytes and GTPgammaS assay in CHO-K1 membrane preparations. In both assays, buprenorphine behaved as a partial agonist compared to nociceptin itself. The N/OFQ agonism of buprenorphine might contribute to actions of buprenorphine in pain models in vivo beside its mu- or kappa-opioid receptor mediated effects.

Topics: Analgesics, Opioid; Animals; Barium Compounds; Buprenorphine; Chlorides; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Genes, Reporter; Guanosine 5'-O-(3-Thiotriphosphate); Naloxone; Narcotic Antagonists; Nociceptin Receptor; Oocytes; Patch-Clamp Techniques; Potassium Channels; Protein Binding; Receptors, Opioid; Xenopus

2000