Compounds > bupivacaine

bupivacaine and lactic acid

bupivacaine has been researched along with lactic acid in 54 studies

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19906 (11.11)18.7374
1990's14 (25.93)18.2507
2000's17 (31.48)29.6817
2010's17 (31.48)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Jauch, KW; Sirtl, C; Zitzelsberger, M1
Adams, HA; Hempelmann, G; Michaelis, G; Wolf, C1
Kashimoto, S; Kumazawa, T; Kume, M1
Coyle, DE; Park, RE1
Arthur, GR; Bridenbaugh, PO; Coyle, DE; Denson, DD; Myers, JA; Thompson, GA1
Coyle, DE; Denson, DD; Myers, JA1
Christensen, NJ; Hasselstrøm, LJ; Kehlet, H; Mogensen, T1
Coyle, D; Denson, D; Myers, J; Thompson, G1
Jorfeldt, L; Wiklund, L1
Chevanne, F; Estèbe, JP; Le Corre, P; Le Verge, R; Mallédant, Y1
Arcuri, E; Barbieri, R; Fanciulli, M; Floridi, A; Pulselli, R1
Berg, EM; Bjella, L; Christensen, O; Gisvold, SE; Levang, OW; Stenseth, R1
Bachmann-Mennenga, B; Biscoping, J; Erkens, U; Hempelmann, G; Kuhn, DF; Ryan, B; Schürg, R1
Berde, C; Castillo, J; Chasin, M; Curley, J; Hernandez, S; Hotz, J; Langer, R; Lim, JO; Tigner, J; Uezono, M1
Fletcher, D; Guilbaud, G; Le Corre, P; Le Verge, R1
Benziger, D; Berde, CB; Dräger, C; Gao, F1
Biber, B; Johansson, G; Kolmodin, J; Koskinen, LO; Lehtipalo, S1
Cilurzo, F; Ciranni Signoretti, E; Conti, B; Fattibene, P; Genta, I; Montanari, L; Valvo, L1
Garry, MG; Geier, HE; Hargreaves, KM; Jackson, DL; Southam, M1
Bernardo, MV; Blanco, MD; Gómez, C; Muñiz, E; Teijón, JM1
Kinney, RC; Kohane, DS; Langer, R; Lipp, M; Lotan, N1
Anthony, DC; Kinney, RC; Kohane, DS; Langer, R; Lipp, M; Lotan, N; Louis, DN1
Chevanne, F; Clément, R; Du Plessis, L; Ecoffey, C; Estèbe, JP; Le Corre, P; Le Verge, R1
Buttafava, A; Cilurzo, F; Conti, B; Faucitano, A; Genta, I; Groppo, A; Montanari, L; Valvo, L1
Bonney, IM; Carr, DB; Hasirci, V; Lipkowski, AW; Sendil, D; Wise, DL1
Płaczek, M; Sznitowska, M1
Cilurzo, F; Conti, B; Genta, I; Montanari, L; Orsini, F; Poletti, G; Selmin, F; Valvo, L1
Altunay, H; Hasirci, V; Sendil-Keskin, D; Wise, DL1
Bonney, I; Carr, DB; Goudas, LC; Hasirci, V; Shuster, L; Wise, DL1
Arner, P; Dungner, E; Felländer-Tsai, L; Högberg, E; Wredmark, T1
Hwang, SJ; Kim, JS; Kim, MS; Lee, BC; Lee, S; Park, HJ; Woo, JS1
Bodmeier, R; Brazeau, GA; Kranz, H; Yilmaz, E1
Gao, S; Lu, Y; Sun, D; Zhang, G; Zhang, H; Zhong, Y1
Bodmeier, R; Kranz, H1
Domb, AJ; Golovanevski, L; Sokolsky-Papkov, M; Weiniger, CF3
Cave, G; Harvey, M1
Edelman, G; Edelman, L; Feinstein, DL; Gregorio, GD; Hiller, DB; Kelly, K; Massad, M; Ripper, R; Weinberg, GL1
Chen, L; Ma, A; Ye, J; Zhou, Z; Zou, F1
Alexander, MR; Davies, MC; Gilmore, IS; Green, FM; Lee, JL; Ogaki, R1
Fecteau, C; Johnson, C; Labadie-Suckow, SM; Suckow, MA; Wolter, WR1
Bae, SA; Kohane, DS; Langer, R; Lawlor, MW; Shichor, I; Shomron, N; Zoldan, J1
Lee, KJ; Ryu, W; Yang, SY1
Anderson, DG; Kohane, DS; Ma, M; Nguyen, VT; Shankarappa, SA; Tsui, JH; Weldon, CB1
Kohane, DS; McAlvin, JB; Reznor, G; Shankarappa, SA; Stefanescu, CF1
Domb, AJ; Golovanevski, L; Haze, A; Ickowicz, DE; Weiniger, CF1
Ben-Gal, TS; Gilboa, E; Shemesh, M; Zilberman, M1
Shemesh, M; Zilberman, M1
Allegri, M; Balliano, MA; Corradetti, B; Minardi, S; Taraballi, F; Tasciotti, E; Van Eps, JL; Yazdi, IK1
Dinh, VV; Lim, YT; Suh, YS; Yang, HK1
Li, T; Ma, P; Sheng, X; Sun, Y; Wang, K; Wang, S; Xing, H1
Dai, F; Hurwitz, O; LaMotte, RH; Ma, C; Shimada, SG; Tian, D; Wang, T; Zhou, J1

Trials

5 trial(s) available for bupivacaine and lactic acid

ArticleYear
[Post-aggression metabolism and peridural anesthesia: modification of catabolism by anesthesia procedures?].
    Langenbecks Archiv fur Chirurgie, 1990, Volume: 375, Issue:5

    Topics: Adult; Aged; Analgesia, Epidural; Anesthesia, Endotracheal; Anesthesia, Epidural; Blood Glucose; Blood Proteins; Bupivacaine; Energy Metabolism; Fatty Acids, Nonesterified; Female; Fentanyl; Gastrectomy; Glycerol; Humans; Lactates; Lactic Acid; Lipids; Male; Middle Aged; Pain Measurement; Parenteral Nutrition, Total; Stomach Neoplasms

1990
[Postoperative course and endocrine stress reaction of geriatric patients with para-articular hip fractures. Prospective randomized study comparing spinal anesthesia and halothane intubation narcosis].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1990, Volume: 25, Issue:4

    Topics: Adrenocorticotropic Hormone; Aged; Aged, 80 and over; Anesthesia, Endotracheal; Anesthesia, Spinal; Blood Pressure; Bupivacaine; Epinephrine; Female; Femoral Neck Fractures; Glycerol; Halothane; Heart Rate; Hormones; Humans; Hydrocortisone; Lactates; Lactic Acid; Male; Mepivacaine; Middle Aged; Norepinephrine; Postoperative Complications; Prospective Studies; Stress, Physiological; Vasopressins

1990
Effects of intravenous bupivacaine on cardiovascular function and plasma catecholamine levels in humans.
    Anesthesia and analgesia, 1984, Volume: 63, Issue:12

    Topics: Adult; Blood Glucose; Blood Pressure; Bupivacaine; Cardiac Output; Epinephrine; Fatty Acids, Nonesterified; Female; Heart; Heart Rate; Humans; Hydrocortisone; Lactates; Lactic Acid; Male; Norepinephrine; Oxygen Consumption; Venous Pressure

1984
Thoracic epidural analgesia in aortocoronary bypass surgery. II: Effects on the endocrine metabolic response.
    Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:8

    Topics: Analgesia, Epidural; Anesthesia, Intravenous; Blood Glucose; Bupivacaine; Coronary Artery Bypass; Coronary Disease; Epinephrine; Fatty Acids, Nonesterified; Fentanyl; Humans; Hydrocortisone; Lactates; Lactic Acid; Male; Middle Aged; Norepinephrine; Vascular Resistance

1994
Continuous interscalene brachial plexus block for postoperative analgesia following shoulder surgery.
    Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:3

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Arthroplasty; Brachial Plexus; Bupivacaine; Female; Glucose; Glycerol; Humans; Lactic Acid; Male; Microdialysis; Middle Aged; Morphine; Nerve Block; Pain Measurement; Pain, Postoperative; Shoulder Joint

1999

Other Studies

49 other study(ies) available for bupivacaine and lactic acid

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Functional and metabolic effects of bupivacaine and lignocaine in the rat heart-lung preparation.
    British journal of anaesthesia, 1990, Volume: 65, Issue:4

    Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiac Output; Glycogen; Heart; Heart Rate; Lactates; Lactic Acid; Lidocaine; Lung; Male; Myocardium; Rats; Rats, Inbred WKY

1990
Effect of different acidification on in vitro human serum bupivacaine binding.
    Biochemical pharmacology, 1985, Oct-15, Volume: 34, Issue:20

    Topics: Blood; Blood Chemical Analysis; Blood Proteins; Bupivacaine; Carbon Dioxide; Chromatography, Gas; Female; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lactates; Lactic Acid; Male; Protein Binding; Serum Albumin

1985
The influence of lactic acid on the serum protein binding of bupivacaine: species differences.
    Anesthesiology, 1984, Volume: 61, Issue:2

    Topics: Acidosis; Animals; Binding Sites; Blood Proteins; Bupivacaine; Dogs; Female; Haplorhini; Humans; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Male; Protein Binding; Rats; Rats, Inbred Strains; Sheep; Species Specificity; Ultrafiltration

1984
The clinical relevance of the drug displacement interaction between meperidine and bupivacaine.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 45, Issue:3

    Topics: Binding, Competitive; Blood Proteins; Bupivacaine; Drug Interactions; Female; Humans; Lactates; Lactic Acid; Male; Meperidine; Orosomucoid; Protein Binding; Serum Albumin; Ultrafiltration

1984
Alpha 1-acid glycoprotein and albumin in human serum bupivacaine binding.
    Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:3

    Topics: Bupivacaine; Female; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Lactates; Lactic Acid; Male; Orosomucoid; Protein Binding; Serum Albumin

1984
Splanchnic turn-over of some energy metabolites and acid-base balance during intravenous infusion of lidocaine, bupivacaine or etidocaine.
    Acta anaesthesiologica Scandinavica, 1981, Volume: 25, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetanilides; Acid-Base Equilibrium; Adult; Blood Glucose; Bupivacaine; Energy Metabolism; Etidocaine; Female; Glycerol; Humans; Hydroxybutyrates; Infusions, Parenteral; Lactates; Lactic Acid; Lidocaine; Male; Oxygen Consumption; Splanchnic Circulation; Sympathetic Nervous System

1981
Spinal controlled delivery of bupivacaine from DL-lactic acid oligomer microspheres.
    Journal of pharmaceutical sciences, 1995, Volume: 84, Issue:1

    Topics: Animals; Biopharmaceutics; Bupivacaine; Delayed-Action Preparations; Drug Delivery Systems; Hindlimb; Injections, Spinal; Lactates; Lactic Acid; Male; Microspheres; Molecular Weight; Nerve Block; Rabbits; Spinal Cord

1995
Effect of the local anesthetic bupivacaine on the energy metabolism of Ehrlich ascites tumor cells.
    Oncology research, 1994, Volume: 6, Issue:12

    Topics: Adenosine Triphosphate; Animals; Bupivacaine; Carcinoma, Ehrlich Tumor; Deoxyglucose; Electron Transport; Energy Metabolism; Glycolysis; Hexokinase; Lactates; Lactic Acid; Male; Mice; Mitochondria; NADP; Neoplasm Proteins; Oligomycins; Ouabain; Oxygen Consumption; Proton-Translocating ATPases; Tumor Cells, Cultured

1994
Intercostal nerve block, interpleural analgesia, thoracic epidural block or systemic opioid application for pain relief after thoracotomy?
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1993, Volume: 7, Issue:1

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Analgesia, Epidural; Anesthesia, Conduction; Blood Glucose; Bupivacaine; Buprenorphine; Epinephrine; Fatty Acids, Nonesterified; Female; Humans; Hydrocortisone; Infusions, Intravenous; Intercostal Nerves; Lactates; Lactic Acid; Male; Middle Aged; Nerve Block; Norepinephrine; Pain Measurement; Pain, Postoperative; Pleura; Pulmonary Gas Exchange; Thoracotomy

1993
Prolonged regional nerve blockade. Injectable biodegradable bupivacaine/polyester microspheres.
    Anesthesiology, 1996, Volume: 84, Issue:6

    Topics: Anesthetics, Local; Animals; Biodegradation, Environmental; Bupivacaine; Dexamethasone; Injections; Lactic Acid; Male; Microspheres; Nerve Block; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Time Factors

1996
Antinociceptive effect of bupivacaine encapsulated in poly(D,L)-lactide-co-glycolide microspheres in the acute inflammatory pain model of carrageenin-injected rats.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:1

    Topics: Acute Disease; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Drug Compounding; Inflammation; Injections, Subcutaneous; Lactic Acid; Male; Microspheres; Pain; Pain Measurement; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley

1997
Prolonged intercostal nerve blockade in sheep using controlled-release of bupivacaine and dexamethasone from polymer microspheres.
    Anesthesiology, 1998, Volume: 89, Issue:4

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bupivacaine; Delayed-Action Preparations; Dexamethasone; Drug Synergism; Female; Intercostal Nerves; Lactic Acid; Microspheres; Nerve Block; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sheep

1998
[The effectiveness of gamma-irradiated products on microspheres of polylactide-co-glycolide containing bupivacaine].
    Bollettino chimico farmaceutico, 1999, Volume: 138, Issue:3

    Topics: Anesthetics, Local; Biocompatible Materials; Bupivacaine; Electron Spin Resonance Spectroscopy; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers

1999
Evaluation of the efficacy of a bioerodible bupivacaine polymer system on antinociception and inflammatory mediator release.
    Pain, 1999, Volume: 82, Issue:1

    Topics: Anesthetics, Local; Animals; Biocompatible Materials; Biodegradation, Environmental; Bradykinin; Bupivacaine; Drug Implants; Immunohistochemistry; Inflammation Mediators; Lactic Acid; Male; Microdialysis; Pain; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Substance P

1999
Bupivacaine-loaded comatrix formed by albumin microspheres included in a poly(lactide-co-glycolide) film: in vivo biocompatibility and drug release studies.
    Biomaterials, 1999, Volume: 20, Issue:20

    Topics: Animals; Biocompatible Materials; Bupivacaine; Delayed-Action Preparations; Drug Carriers; Drug Implants; Lactic Acid; Male; Microscopy, Electron, Scanning; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Wistar; Serum Albumin, Bovine; Time Factors

1999
Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine.
    Pharmaceutical research, 2000, Volume: 17, Issue:10

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Anesthetics, Local; Animals; Bupivacaine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Lactic Acid; Lactose; Male; Microspheres; Nerve Block; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Serum Albumin

2000
Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium.
    Journal of biomedical materials research, 2002, Mar-05, Volume: 59, Issue:3

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Anesthetics, Local; Animals; Biocompatible Materials; Bupivacaine; Delayed-Action Preparations; Drug Delivery Systems; Inflammation; Lactic Acid; Lactose; Male; Microspheres; Nerve Block; Peripheral Nerves; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Serum Albumin; Time Factors

2002
Spray-dryed bupivacaine-loaded microspheres: in vitro evaluation and biopharmaceutics of bupivacaine following brachial plexus administration in sheep.
    International journal of pharmaceutics, 2002, May-15, Volume: 238, Issue:1-2

    Topics: Anesthetics, Local; Animals; Biopharmaceutics; Body Weight; Brachial Plexus; Bupivacaine; Chemistry, Pharmaceutical; Excipients; Female; Half-Life; Infusions, Intravenous; Injections; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sheep; Solubility

2002
Gamma irradiation effects and EPR investigation on poly(lactide-co-glycolide) microspheres containing bupivacaine.
    Farmaco (Societa chimica italiana : 1989), 2002, Volume: 57, Issue:6

    Topics: Alanine; Biphenyl Compounds; Bupivacaine; Cobalt Radioisotopes; Drug Stability; Electron Spin Resonance Spectroscopy; Free Radicals; Gamma Rays; Kinetics; Lactic Acid; Microspheres; Oxygen; Particle Size; Picrates; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Reference Standards; Sensitivity and Specificity; Temperature; Time Factors; Vacuum

2002
Antinociceptive effects of hydromorphone, bupivacaine and biphalin released from PLGA polymer after intrathecal implantation in rats.
    Biomaterials, 2003, Volume: 24, Issue:11

    Topics: Analgesics; Animals; Bupivacaine; Drug Delivery Systems; Drug Implants; Enkephalins; Hydromorphone; Injections, Spinal; Lactic Acid; Male; Pain; Pain Measurement; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley

2003
Use of 1,4-dioxan for preparation of bupivacaine loaded PLGA microspheres with an o/w emulsion extraction process.
    Die Pharmazie, 2003, Volume: 58, Issue:6

    Topics: Anesthetics, Local; Bupivacaine; Dioxanes; Drug Compounding; Emulsions; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solubility

2003
Poly(lactide-co-glycolide) microspheres containing bupivacaine: comparison between gamma and beta irradiation effects.
    Journal of controlled release : official journal of the Controlled Release Society, 2003, Jul-31, Volume: 90, Issue:3

    Topics: Anesthetics, Local; Beta Particles; Bupivacaine; Calorimetry, Differential Scanning; Drug Carriers; Drug Stability; Gamma Rays; Glycolates; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Spectroscopy, Fourier Transform Infrared; Sterilization; Temperature; Time Factors

2003
In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems.
    Journal of biomaterials science. Polymer edition, 2003, Volume: 14, Issue:6

    Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Biocompatible Materials; Biodegradation, Environmental; Bupivacaine; Codeine; Drug Delivery Systems; Drug Implants; Female; Hydromorphone; Lactic Acid; Morphine; Pain; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Time Factors

2003
Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model.
    Life sciences, 2003, Nov-14, Volume: 73, Issue:26

    Topics: Analgesics, Opioid; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Implants; Drug Therapy, Combination; Hindlimb; Hot Temperature; Hydromorphone; Hyperalgesia; Lactic Acid; Ligation; Male; Pain; Pain Measurement; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Sciatic Nerve

2003
Changes in metabolism and blood flow following catecholamine stimulation in the synovial membrane measured with microdialysis.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2006, Volume: 14, Issue:2

    Topics: Adipose Tissue; Adolescent; Adult; Anesthetics, Local; Arthroscopy; Bupivacaine; Dialysis Solutions; Dihydralazine; Dose-Response Relationship, Drug; Drug Combinations; Epinephrine; Ethanol; Female; Glucose; Glycerol; Humans; Injections, Intra-Articular; Knee Joint; Lactic Acid; Male; Microdialysis; Middle Aged; Regional Blood Flow; Synovial Membrane; Vasoconstrictor Agents

2006
Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique.
    Journal of microencapsulation, 2006, Volume: 23, Issue:7

    Topics: Absorbable Implants; Biocompatible Materials; Bupivacaine; Chemical Precipitation; Delayed-Action Preparations; Drug Compounding; Hydrochloric Acid; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Particle Size; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solvents; Surface Properties; X-Ray Diffraction

2006
In vitro and in vivo drug release from a novel in situ forming drug delivery system.
    Pharmaceutical research, 2008, Volume: 25, Issue:6

    Topics: Animals; Bupivacaine; Chemistry, Pharmaceutical; Drug Delivery Systems; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Solubility

2008
Bupivacaine-loaded biodegradable poly(lactic-co-glycolic) acid microspheres I. Optimization of the drug incorporation into the polymer matrix and modelling of drug release.
    International journal of pharmaceutics, 2008, Mar-03, Volume: 351, Issue:1-2

    Topics: Anesthetics, Local; Bupivacaine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Emulsions; Lactic Acid; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility

2008
Structure formation and characterization of injectable drug loaded biodegradable devices: in situ implants versus in situ microparticles.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008, Jul-03, Volume: 34, Issue:2-3

    Topics: Absorbable Implants; Anesthetics, Local; Bupivacaine; Chromatography, High Pressure Liquid; Excipients; Lactic Acid; Microscopy, Electron, Scanning; Nanoparticles; Pharmaceutical Preparations; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solubility; Solvents; Viscosity

2008
Prolonged local anesthetic action through slow release from poly (lactic acid co castor oil).
    Pharmaceutical research, 2009, Volume: 26, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Castor Oil; Chemistry, Pharmaceutical; Delayed-Action Preparations; Female; Hydrolysis; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Motor Activity; Pain Measurement; Pharmaceutic Aids; Polyesters; Reproducibility of Results; Viscosity

2009
Bupivacaine-induced cardiac arrest: fat is good-is epinephrine really bad?
    Anesthesiology, 2009, Volume: 111, Issue:3

    Topics: Anesthetics, Local; Bupivacaine; Epinephrine; Fat Emulsions, Intravenous; Heart Arrest; Hemodynamics; Humans; Lactic Acid; Sympathetic Nervous System; Vasoconstrictor Agents; Vasopressins

2009
Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect.
    Anesthesiology, 2009, Volume: 111, Issue:3

    Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Bupivacaine; Drug Overdose; Electrocardiography; Epinephrine; Fat Emulsions, Intravenous; Hemodynamics; Lactic Acid; Male; Rats; Rats, Sprague-Dawley; Resuscitation; Vasoconstrictor Agents

2009
Poly(DL:lactic acid-castor oil) 3:7-bupivacaine formulation: reducing burst effect prolongs efficacy in vivo.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:6

    Topics: Anesthetics, Local; Animals; Bupivacaine; Castor Oil; Chemistry, Pharmaceutical; Dosage Forms; Female; Lactic Acid; Mice; Mice, Inbred ICR; Polymers; Sciatic Nerve; Transferases (Other Substituted Phosphate Groups)

2010
Simultaneous determination of ropivacaine, bupivacaine and dexamethasone in biodegradable PLGA microspheres by high performance liquid chromatography.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2010, Volume: 130, Issue:8

    Topics: Adjuvants, Anesthesia; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Chromatography, High Pressure Liquid; Dexamethasone; Drug Delivery Systems; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Ropivacaine; Ultraviolet Rays

2010
Surface mass spectrometry of two component drug-polymer systems: novel chromatographic separation method using gentle-secondary ion mass spectrometry (G-SIMS).
    Analytical chemistry, 2011, May-15, Volume: 83, Issue:10

    Topics: Bupivacaine; Codeine; Lactic Acid; Pharmaceutical Preparations; Polyesters; Polymers; Spectrometry, Mass, Secondary Ion

2011
Bupivacaine-enhanced small intestinal submucosa biomaterial as a hernia repair device.
    Journal of biomaterials applications, 2012, Volume: 27, Issue:2

    Topics: Abdominal Wall; Absorbable Implants; Anesthetics, Local; Animals; Biocompatible Materials; Bupivacaine; Drug Delivery Systems; Herniorrhaphy; Intestinal Mucosa; Intestine, Small; Lactic Acid; Male; Pain, Postoperative; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Swine

2012
Long-acting poly(DL:lactic acid-castor oil) 3:7-bupivacaine formulation: effect of hydrophobic additives.
    Pharmaceutical research, 2011, Volume: 28, Issue:12

    Topics: Anesthetics, Local; Animals; Bupivacaine; Castor Oil; Female; Hydrophobic and Hydrophilic Interactions; Injections; Lactic Acid; Mice; Motor Activity; Ricinoleic Acids; Sciatic Nerve; Sensation; Viscosity

2011
Toxicogenomic analysis of a sustained release local anesthetic delivery system.
    Biomaterials, 2012, Volume: 33, Issue:13

    Topics: Amitriptyline; Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Dexamethasone; Gene Expression Regulation; Lactic Acid; Male; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Sciatic Nerve; Tetrodotoxin; Toxicogenetics

2012
Controlled release of bupivacaine HCl through microchannels of biodegradable drug delivery device.
    Biomedical microdevices, 2012, Volume: 14, Issue:3

    Topics: Analgesics; Buffers; Bupivacaine; Citric Acid; Delayed-Action Preparations; Equipment Design; Hydrogen-Ion Concentration; Lactic Acid; Microfluidics; Microscopy, Electron, Scanning; Pain Management; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Postoperative Care; Succinic Acid

2012
Electrospun drug-eluting sutures for local anesthesia.
    Journal of controlled release : official journal of the Controlled Release Society, 2012, Aug-10, Volume: 161, Issue:3

    Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Drug Delivery Systems; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Skin; Sutures; Wound Healing

2012
Local toxicity from local anesthetic polymeric microparticles.
    Anesthesia and analgesia, 2013, Volume: 116, Issue:4

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cell Survival; Cells, Cultured; Drug Delivery Systems; Injections; Lactic Acid; Lidocaine; Male; Mice; Microscopy, Electron, Scanning; Muscle Fibers, Skeletal; Nanoparticles; Nerve Block; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats, Sprague-Dawley; Sciatic Nerve

2013
Extended release local anesthetic agents in a postoperative arthritic pain model.
    Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:1

    Topics: Anesthetics; Anesthetics, Local; Animals; Bupivacaine; Castor Oil; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Knee Joint; Lactic Acid; Male; Pain Measurement; Pain, Postoperative; Polyesters; Polymers; Rats; Rats, Sprague-Dawley

2014
Controlled release of analgesic drugs from porous bioresorbable structures for various biomedical applications.
    Journal of biomaterials science. Polymer edition, 2014, Volume: 25, Issue:4

    Topics: Analgesics; Biocompatible Materials; Bupivacaine; Delayed-Action Preparations; Drug Delivery Systems; Emulsions; Ibuprofen; Lactic Acid; Microscopy, Electron, Scanning; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Surface-Active Agents; Tissue Engineering

2014
Structure-property effects of novel bioresorbable hybrid structures with controlled release of analgesic drugs for wound healing applications.
    Acta biomaterialia, 2014, Volume: 10, Issue:3

    Topics: Absorption, Physicochemical; Analgesics; Animals; Biocompatible Materials; Bupivacaine; Cryoelectron Microscopy; Delayed-Action Preparations; Ibuprofen; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Steam; Structure-Activity Relationship; Sus scrofa; Tensile Strength; Water; Wound Healing

2014
Potential avoidance of adverse analgesic effects using a biologically "smart" hydrogel capable of controlled bupivacaine release.
    Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:11

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cell Line; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparations; Drug Carriers; Hydrogels; Hydrogen-Ion Concentration; Inflammation Mediators; Kinetics; Lactic Acid; Macrophages; Mice; Particle Size; Phagocytosis; Poloxamer; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Technology, Pharmaceutical

2014
Spatiotemporal Programing for the On-Demand Release of Bupivacaine Based on an Injectable Composite Hydrogel.
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:12

    Topics: Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Drug Administration Routes; Drug Carriers; Drug Delivery Systems; Hydrogel, Polyethylene Glycol Dimethacrylate; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Time Factors

2016
Local anesthetic effects of bupivacaine loaded lipid-polymer hybrid nanoparticles: In vitro and in vivo evaluation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cell Survival; Cells, Cultured; Delayed-Action Preparations; Drug Delivery Systems; Drug Stability; Lactic Acid; Lipids; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Pain Measurement; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solubility

2017
Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.
    Neuroscience letters, 2018, 03-06, Volume: 668

    Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Lactic Acid; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Nerve Compression Syndromes; Nociception; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer

2018