Page last updated: 2024-08-25

bufuralol and propranolol

bufuralol has been researched along with propranolol in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199010 (50.00)18.7374
1990's1 (5.00)18.2507
2000's4 (20.00)29.6817
2010's5 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carrupt, PA; el Tayar, N; Testa, B; Van de Waterbeemd, H1
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Dalvie, D; Loi, CM; Smith, DA1
Beretta-Piccoli, C; de Châtel, RD; Hirsch, D; Reubi, FC; Weidmann, P; Ziegler, W1
Bonelli, J; Kaik, G; Magometschnigg, D; Rameis, H1
Lennard, MS1
Smith, RL1
East, PB; Francis, RJ; Pringle, TH; Shanks, RG1
Belz, GG; Matthews, JH; Palm, D; Wellstein, A1
Finch, MB; Johnston, GD; Shanks, RG1
Lennard, MS; Ramsay, LE; Silas, JH; Tucker, GT; Woods, HF1
Balant, LP; Dayer, P; Fabre, J1
Cho, AK; Distefano, EW; Fujimoto, M; Jayasinghe, A; Lin, LY; Schmitz, DA1
Chow, T; Funae, Y; Hiroi, T; Imaoka, S1

Reviews

3 review(s) available for bufuralol and propranolol

ArticleYear
Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:11

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Models, Molecular; Receptors, Adrenergic, beta; Structure-Activity Relationship

1988
Oxidation phenotype and the metabolism and action of beta-blockers.
    Klinische Wochenschrift, 1985, Apr-01, Volume: 63, Issue:7

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Drug Interactions; Ethanolamines; Humans; Hypertension; Kinetics; Metoprolol; Oxidation-Reduction; Phenotype; Propranolol; Timolol

1985
Consequences of renal insufficiency on the hepatic clearance of some drugs.
    International journal of clinical pharmacology research, 1983, Volume: 3, Issue:6

    Topics: Adrenergic beta-Antagonists; Biotransformation; Dextropropoxyphene; Ethanolamines; Humans; Kidney Diseases; Kidney Failure, Chronic; Kinetics; Liver; Models, Biological; Oxprenolol; Pharmaceutical Preparations; Propanolamines; Propranolol; Renal Dialysis

1983

Trials

3 trial(s) available for bufuralol and propranolol

ArticleYear
[Interrelations between blood pressure, blood volume, plasma renin and urinary catecholamines during beta-blockade in essential hypertension (author's transl)].
    Klinische Wochenschrift, 1976, Aug-15, Volume: 54, Issue:16

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Benzofurans; Blood Pressure; Blood Volume; Body Weight; Catecholamines; Ethanolamines; Female; Humans; Hypertension; Male; Middle Aged; Norepinephrine; Potassium; Propranolol; Renin

1976
Pharmacodynamic and pharmacokinetic studies on bufuralol in man.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Double-Blind Method; Ethanolamines; Heart Rate; Humans; Kinetics; Male; Physical Exertion; Propranolol; Random Allocation

1986
Peripheral vascular effects of bufuralol in hypertensive and normal subjects: a comparison with propranolol and pindolol.
    European journal of clinical pharmacology, 1986, Volume: 30, Issue:6

    Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Ethanolamines; Fingers; Forearm; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pindolol; Propranolol; Regional Blood Flow

1986

Other Studies

14 other study(ies) available for bufuralol and propranolol

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
Hemodynamic changes in hypertensive patients at rest and during physical exercise before and after acute i.v. administration of bufuralol-HCl or propranolol.
    International journal of clinical pharmacology and biopharmacy, 1979, Volume: 17, Issue:8

    Topics: Adrenergic beta-Antagonists; Adult; Benzofurans; Ethanolamines; Hemodynamics; Humans; Hypertension; Middle Aged; Physical Exertion; Propranolol; Rest

1979
Polymorphic metabolism of the beta-adrenoreceptor blocking drugs and its clinical relevance.
    European journal of clinical pharmacology, 1985, Volume: 28 Suppl

    Topics: Adrenergic beta-Antagonists; Animals; Biological Availability; Blood Pressure; Debrisoquin; Ethanolamines; Glucuronates; Humans; Hydroxylation; Kinetics; Lipids; Metoprolol; Phenotype; Polymorphism, Genetic; Propranolol; Solubility; Structure-Activity Relationship; Timolol

1985
In vitro receptor occupancy allows to establish equieffective doses of beta-blockers with different pharmacodynamic profiles in man. Investigations with propranolol and bufuralol.
    Methods and findings in experimental and clinical pharmacology, 1985, Volume: 7, Issue:12

    Topics: Adult; Binding, Competitive; Ethanolamines; Heart Rate; Humans; In Vitro Techniques; Kinetics; Male; Propranolol; Receptors, Adrenergic, beta; Reticulocytes; Stroke Volume; Vascular Resistance

1985
Polymorphic metabolism of beta-adrenoceptor antagonists.
    British journal of clinical pharmacology, 1984, Volume: 17 Suppl 1

    Topics: Adrenergic beta-Antagonists; Biotransformation; Drug Interactions; Ethanolamines; Heart Rate; Humans; Metoprolol; Propranolol

1984
Selective mechanism-based inactivation of rat CYP2D by 4-allyloxymethamphetamine.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Dealkylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanolamines; Female; Male; Methamphetamine; Phencyclidine; Propranolol; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

1996
Catalytic specificity of CYP2D isoforms in rat and human.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:9

    Topics: Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Debrisoquin; Ethanolamines; Humans; In Vitro Techniques; Isoenzymes; Magnetic Resonance Spectroscopy; Microsomes, Liver; Mixed Function Oxygenases; Propranolol; Rats; Recombinant Proteins; Substrate Specificity

2002