Page last updated: 2024-08-25

bufuralol and midazolam

bufuralol has been researched along with midazolam in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.55)18.2507
2000's12 (54.55)29.6817
2010's8 (36.36)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Kanebratt, KP; Sjögren, E; Svanberg, P1
Dalvie, D; Loi, CM; Smith, DA1
Bonnabry, P; Dayer, P; Leemann, T1
Fujita, K; Kamataki, T; Nakayama, K; Nohmi, T; Tsuruma, K; Yamada, M; Yamazaki, Y1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K1
Kokue, E; Kuroha, M; Kuze, Y; Shimoda, M1
Beattie, IG; Graham, KS; Riley, RJ; Weaver, R1
DeSante, KA; Gillespie, JS; Jensen, CB; Long, AJ; Petullo, D; Read, HA; Ring, B; Sanburn, NP; Sauer, JM; Smith, BP; VandenBranden, MR; Witcher, JW; Wrighton, SA1
Kokue, E; Kuroha, M; Shibata, Y; Shimoda, M; Zhang, K1
Heim, J; Jensen, NS; Li, L; Pan, RM; Porter, TD; Ring, B; Russo, G; Silber, P; Tine, JA; Wedlund, PJ1
Carter, GT; Di, L; Kerns, EH; Li, SQ1
Regmi, NL; Sanda, S; Sasaki, K; Shah, SS; Shimoda, M1
Hall, SD; Harrelson, JP; Mao, J; Mohutsky, MA; Wrighton, SA1
Furue, MK; Hayakawa, T; Higuchi, M; Inamura, M; Kawabata, K; Kikuchi, K; Mizuguchi, H; Nagamoto, Y; Sakurai, F; Sugawara, M; Takayama, K; Tashiro, K; Watanabe, H1
Chen, Y; Subramanian, R; Zhu, X1
Gaudette, F; Huguet, J; Michaud, V; Turgeon, J1
Andersson, TB; Artursson, P; Christensen, H; Krogstad, V; Matsson, P; Urdzik, J; Wegler, C1

Trials

1 trial(s) available for bufuralol and midazolam

ArticleYear
Effect of oral administration of clinically relevant doses of dexamethasone on regulation of cytochrome P450 subfamilies in hepatic microsomes from dogs and rats.
    American journal of veterinary research, 2006, Volume: 67, Issue:2

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Cytochrome P-450 Enzyme System; Dexamethasone; Dogs; Ethanolamines; Hypnotics and Sedatives; Hypoglycemic Agents; Male; Microsomes, Liver; Midazolam; Oxazines; Rats; Rats, Wistar; Tolbutamide

2006

Other Studies

21 other study(ies) available for bufuralol and midazolam

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Kinetics; Microsomes, Liver; Research Design; Tandem Mass Spectrometry

2012
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
Selective inhibition of major drug metabolizing cytochrome P450 isozymes in human liver microsomes by carbon monoxide.
    Life sciences, 1994, Volume: 54, Issue:14

    Topics: Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating

1994
Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase.
    Environmental and molecular mutagenesis, 2001, Volume: 38, Issue:4

    Topics: Alkylating Agents; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Ethanolamines; Genetic Engineering; Humans; Midazolam; Mixed Function Oxygenases; Mutagenicity Tests; NADP; NADPH-Ferrihemoprotein Reductase; Nitrosamines; Recombinant Proteins; Salmonella typhimurium; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases

2001
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
    Biochemical pharmacology, 2002, Mar-01, Volume: 63, Issue:5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured

2002
In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes.
    American journal of veterinary research, 2002, Volume: 63, Issue:6

    Topics: Animals; Antifungal Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Ethanolamines; Isoenzymes; Ketoconazole; Kinetics; Male; Microsomes, Liver; Midazolam; Oxazines; Tolbutamide

2002
Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Drug Design; Drug Industry; Drug Interactions; Drugs, Investigational; Escherichia coli; Ethanolamines; Evaluation Studies as Topic; Kinetics; Mass Spectrometry; Mephenytoin; Microsomes, Liver; Midazolam; Molecular Probes; Phenacetin; Recombinant Proteins; Substrate Specificity

2003
Atomoxetine hydrochloride: clinical drug-drug interaction prediction and outcome.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:2

    Topics: Aryl Hydrocarbon Hydroxylases; Atomoxetine Hydrochloride; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Diclofenac; Drug Interactions; Ethanolamines; Humans; Hydroxylation; Microsomes, Liver; Midazolam; Phenacetin; Propylamines

2004
New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:8

    Topics: Alleles; Base Sequence; Cryopreservation; Cytochrome P-450 CYP2D6; Ethanolamines; Genotype; Hepatocytes; Humans; In Vitro Techniques; Microsomes, Liver; Midazolam; Molecular Sequence Data; Phenotype

2006
Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS.
    International journal of pharmaceutics, 2007, Apr-20, Volume: 335, Issue:1-2

    Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Drug Design; Drug Interactions; Enzyme Inhibitors; Ethanolamines; Fluorescent Dyes; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Liver; Microsomes, Liver; Midazolam; Recombinant Proteins; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Substrate Specificity; Tandem Mass Spectrometry

2007
Characterization of cytochrome P450-mediated drug metabolism in cats.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Cats; Cytochrome P-450 Enzyme System; Ethanolamines; Female; Hypnotics and Sedatives; Hypoglycemic Agents; Male; Microsomes, Liver; Midazolam; Oxazines; Tolbutamide

2007
Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:4

    Topics: Aryl Hydrocarbon Hydroxylases; Cell Culture Techniques; Cells, Cultured; Chromatography, High Pressure Liquid; Cryopreservation; Culture Media; Culture Media, Serum-Free; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ethanolamines; Hepatocytes; Humans; Hydroxylation; Midazolam; Plasma; Predictive Value of Tests; Substrate Specificity; Tandem Mass Spectrometry

2012
Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.
    Journal of hepatology, 2012, Volume: 57, Issue:3

    Topics: Bupropion; Cell Differentiation; Cell Line; Embryonic Stem Cells; Ethanolamines; Gene Transfer Techniques; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 3-beta; Hepatocytes; Humans; Induced Pluripotent Stem Cells; Midazolam; Paclitaxel; Phenacetin; Testosterone; Tolbutamide; Transduction, Genetic

2012
Comparison of information-dependent acquisition, SWATH, and MS(All) techniques in metabolite identification study employing ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
    Analytical chemistry, 2014, Jan-21, Volume: 86, Issue:2

    Topics: Algorithms; Animals; Biotransformation; Chlorpromazine; Chromatography, High Pressure Liquid; Ethanolamines; Microsomes, Liver; Midazolam; Oxidation-Reduction; Quinidine; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2

    Topics: Bupropion; Butyrophenones; Carbamates; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Ethanolamines; Humans; Lauric Acids; Microsomes; Midazolam; Myocardium; Oxazines; Piperidines; Tolbutamide

2019
Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes.
    Molecular pharmaceutics, 2021, 04-05, Volume: 18, Issue:4

    Topics: Bupropion; Cytochrome P-450 Enzyme System; Diclofenac; Drug Evaluation, Preclinical; Ethanolamines; Hepatobiliary Elimination; Hepatocytes; Humans; Liver; Microsomes, Liver; Midazolam; Omeprazole; Proteome; Proteomics

2021