Compounds > bufuralol
Page last updated: 2024-08-25

bufuralol and dextromethorphan

bufuralol has been researched along with dextromethorphan in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.06)18.7374
1990's5 (15.15)18.2507
2000's13 (39.39)29.6817
2010's13 (39.39)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Kanebratt, KP; Sjögren, E; Svanberg, P1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Dalvie, D; Loi, CM; Smith, DA1
Kronbach, T1
Bargetzi, MJ; Follath, F; Haefeli, WE; Meyer, UA1
Alvarez, F; Gueguen, M; Jacqz-Aigrain, E; Robieux, I; Zanger, UM1
Dayer, P; Leemann, T; Striberni, R1
Catin, T; Gut, J; Kronbach, T; Mathys, D; Meyer, UA1
Bonnabry, P; Dayer, P; Leemann, T1
Gelboin, HV; Gonzalez, FJ; Krausz, KW; Shou, M; Yang, TJ1
Ekins, S; Lawton, MP; Mankowski, DC1
Ayrton, AD; Chenery, R; Clarke, SE; Deeni, YY; Paine, MJ; Wolf, CR1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K1
Crespi, C; Gaedigk, A; Leeder, JS; Marcucci, KA; Pearce, RE; Steimel, DT1
Lin, Y; Mei, Q; Rushmore, TH; Shou, M; Tang, C1
Chiba, K; Hosokawa, M; Kobayashi, K; Shiraishi, T; Taguchi, M; Tainaka, H; Yamaura, Y1
Friis, C; Skaanild, MT1
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y1
Abdel-Rahman, SM; Alander, SW; Bhathena, A; Bradford, LD; Gaedigk, A; Leeder, JS; Ndjountché, L; Pearce, RE; Rogan, PK1
Bonifacio, A; Commandeur, JN; Gooijer, C; Keizers, PH; Robert, B; van der Zwan, G; Vermeulen, NP1
Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA1
Hiratsuka, M; Ishikawa, M; Mizugaki, M; Obata, K; Sakuyama, K; Sasaki, T; Ujiie, S1
Funae, Y; Hanioka, N; Katsu, T; Kazamori, D; Masuda, K; Naito, S; Nakura, H; Narimatsu, S; Yamano, S1
Kohara, S; Murayama, N; Uehara, S; Uno, Y; Yamazaki, H2
Agrawal, V; Giacomini, KM; Kramer, MA; Miller, WL; Morrissey, K; Sandee, D; Tam, HK; Tracy, TS1
Cai, J; Cai, JP; Dai, DP; Geng, PW; Hu, GX; Hu, JH; Hu, LM; Nie, JJ; Wang, SH1
Kohara, S; Murayama, N; Osada, N; Uehara, S; Uno, Y; Yamazaki, H1
Hagihira, Y; Inoue, T; Murayama, N; Sasaki, E; Shimizu, M; Uehara, S; Uno, Y; Yamazaki, H1
Cai, J; Cai, JP; Dai, DP; Geng, PW; Hu, GX; Huang, XX; Wang, H; Wang, SH; Zhan, YY1
Cho, C; Fujiwara, R; Furge, LL; Glass, SM; Glista, MJ; Hicks, MJ; Kamath, SS; Martell, CM; Mills, JM; Osorio-Vasquez, V; Oswalt, AK1
Don, CG; Smieško, M1

Other Studies

33 other study(ies) available for bufuralol and dextromethorphan

ArticleYear
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Kinetics; Microsomes, Liver; Research Design; Tandem Mass Spectrometry

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6.
    Methods in enzymology, 1991, Volume: 206

    Topics: Adrenergic beta-Antagonists; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Ethanolamines; Humans; Microsomes, Liver; Mixed Function Oxygenases; Spectrometry, Fluorescence; Substrate Specificity

1991
Potent inhibition of cytochrome P450IID6 (debrisoquin 4-hydroxylase) by flecainide in vitro and in vivo.
    Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:5

    Topics: Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Debrisoquin; Dextromethorphan; Ethanolamines; Flecainide; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenotype; Sparteine

1990
Cytochrome P450IID subfamily in non-human primates. Catalytical and immunological characterization.
    Biochemical pharmacology, 1991, Jun-01, Volume: 41, Issue:11

    Topics: Animals; Autoantibodies; Binding, Competitive; Cross Reactions; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Ethanolamines; Humans; Isoenzymes; Kinetics; Macaca fascicularis; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating

1991
Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:1

    Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dealkylation; Dextromethorphan; Ethanolamines; Humans; In Vitro Techniques; Kinetics; Levorphanol; Microsomes, Liver; Mixed Function Oxygenases; Polymorphism, Genetic

1989
High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver.
    Analytical biochemistry, 1987, Volume: 162, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Ethanolamines; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, O-Demethylating; Polymorphism, Genetic

1987
Selective inhibition of major drug metabolizing cytochrome P450 isozymes in human liver microsomes by carbon monoxide.
    Life sciences, 1994, Volume: 54, Issue:14

    Topics: Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating

1994
A monoclonal antibody inhibitory to human P450 2D6: a paradigm for use in combinatorial determination of individual P450 role in specific drug tissue metabolism.
    Pharmacogenetics, 1997, Volume: 7, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Ethanolamines; Humans; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mixed Function Oxygenases; Phenanthrenes; Tissue Distribution

1997
Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates.
    Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:8

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Intestines; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Obese; Mice, Transgenic; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Testosterone

2000
Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.
    Archives of biochemistry and biophysics, 2001, Dec-01, Volume: 396, Issue:1

    Topics: Cytochrome P-450 CYP2D6; Dextromethorphan; Escherichia coli; Ethanolamines; Humans; Metoprolol; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Protein Engineering; Recombinant Fusion Proteins; Technology, Pharmaceutical

2001
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
    Biochemical pharmacology, 2002, Mar-01, Volume: 63, Issue:5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured

2002
Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:5

    Topics: Animals; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Ethanolamines; Genetic Variation; Insecta; Kinetics; Phenotype; Substrate Specificity; Transfection

2002
Inhibition kinetics of monoclonal antibodies against cytochromes P450.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:6

    Topics: Aflatoxins; Animals; Antibodies, Monoclonal; Antibody Specificity; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Ethanolamines; Humans; Hybridomas; Hydroxylation; Immunoglobulin G; In Vitro Techniques; Isoenzymes; Kinetics; Macaca mulatta; Mice; Microsomes, Liver; Models, Biological; Rats; Species Specificity; Testosterone

2002
Effects of G169R and P34S substitutions produced by mutations of CYP2D6*14 on the functional properties of CYP2D6 expressed in V79 cells.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:11

    Topics: Alleles; Amino Acid Substitution; Animals; Cell Line; Cricetinae; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dealkylation; Dextromethorphan; DNA, Complementary; Ethanolamines; Gene Expression Regulation, Enzymologic; Hydroxylation; Mutation; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Steroid 21-Hydroxylase

2002
Is cytochrome P450 CYP2D activity present in pig liver?
    Pharmacology & toxicology, 2002, Volume: 91, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Ethanolamines; Female; Male; Microsomes, Liver; Substrate Specificity; Swine; Swine, Miniature

2002
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
    Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:9

    Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone

2004
Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
    The pharmacogenomics journal, 2005, Volume: 5, Issue:3

    Topics: Alleles; Black or African American; Cloning, Molecular; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Female; Gene Expression; Gene Frequency; Genes, Reporter; Genetic Variation; Genotype; Haplotypes; Humans; Liver; Luciferases; Phenotype; Polymorphism, Single Nucleotide; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Splicing; Tramadol; Transcription, Genetic

2005
Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy.
    Biochemical and biophysical research communications, 2006, May-12, Volume: 343, Issue:3

    Topics: Amino Acid Substitution; Binding Sites; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Heme; Humans; Mutation; N-Methyl-3,4-methylenedioxyamphetamine; Spectrum Analysis, Raman

2006
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:8

    Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol

2007
Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12

    Topics: Animals; Catalysis; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Humans; Japan; Kinetics; Microsomes; Polymorphism, Genetic; Transfection

2008
The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol.
    Biochemical pharmacology, 2009, Mar-01, Volume: 77, Issue:5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cytochrome P-450 CYP2D6; Dextromethorphan; DNA Primers; Ethanolamines; Humans; Kinetics; Male; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Substrate Specificity

2009
Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:9

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cytochrome P-450 Enzyme System; Dextromethorphan; DNA Primers; DNA, Complementary; Ethanolamines; Exons; Introns; Macaca fascicularis; Molecular Sequence Data; Open Reading Frames; RNA, Messenger; Sequence Homology, Amino Acid

2010
Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.
    Pharmacogenetics and genomics, 2010, Volume: 20, Issue:11

    Topics: Benzopyrans; Catalysis; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Genetic Variation; Humans; Inactivation, Metabolic; Mutation; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Polymorphism, Genetic

2010
Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:9

    Topics: Animals; Cytochrome P-450 Enzyme System; Dextromethorphan; Escherichia coli; Ethanolamines; Genetic Variation; Genotype; Hydroxylation; Macaca fascicularis; Macaca mulatta; Microsomes, Liver; Polymorphism, Genetic

2014
In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.
    Basic & clinical pharmacology & toxicology, 2015, Volume: 117, Issue:1

    Topics: Asian People; China; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Gene Frequency; Genotype; HEK293 Cells; Humans; Mutation; Phenotype; Substrate Specificity; Transfection

2015
CYP2D44 polymorphisms in cynomolgus and rhesus macaques.
    Molecular biology reports, 2015, Volume: 42, Issue:7

    Topics: Animals; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Ethanolamines; Gene Expression; Genotype; Humans; Hydroxylation; Liver; Macaca fascicularis; Macaca mulatta; Models, Molecular; Mutagenesis, Site-Directed; Polymorphism, Genetic; Sequence Homology, Amino Acid

2015
Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:9

    Topics: Amino Acid Sequence; Animals; Callithrix; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; DNA, Complementary; Ethanolamines; Exons; Gene Expression Regulation, Enzymologic; Humans; Intestine, Small; Introns; Isoenzymes; Kinetics; Liver; Metoprolol; Molecular Sequence Data; Multigene Family; Organ Specificity; Oxidation-Reduction; Phylogeny; Recombinant Proteins; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid

2015
Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 118, Issue:3

    Topics: Alleles; Animals; Asian People; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Gene Expression Regulation; Genetic Variation; Humans; Insecta; Microsomes

2016
CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:8

    Topics: Alleles; Catalytic Domain; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Humans; Imidazoles; Inactivation, Metabolic; Kinetics; Mutation; NADP; Phenotype; Pyrimidines

2018
Microsecond MD simulations of human CYP2D6 wild-type and five allelic variants reveal mechanistic insights on the function.
    PloS one, 2018, Volume: 13, Issue:8

    Topics: Alleles; Benzimidazoles; Catalytic Domain; Cytochrome P-450 CYP2D6; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Heme; Humans; Hydrogen Bonding; Inactivation, Metabolic; Molecular Dynamics Simulation; Substrate Specificity; Tamoxifen

2018