bufuralol has been researched along with dextromethorphan in 33 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (6.06) | 18.7374 |
1990's | 5 (15.15) | 18.2507 |
2000's | 13 (39.39) | 29.6817 |
2010's | 13 (39.39) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Kanebratt, KP; Sjögren, E; Svanberg, P | 1 |
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
Dalvie, D; Loi, CM; Smith, DA | 1 |
Kronbach, T | 1 |
Bargetzi, MJ; Follath, F; Haefeli, WE; Meyer, UA | 1 |
Alvarez, F; Gueguen, M; Jacqz-Aigrain, E; Robieux, I; Zanger, UM | 1 |
Dayer, P; Leemann, T; Striberni, R | 1 |
Catin, T; Gut, J; Kronbach, T; Mathys, D; Meyer, UA | 1 |
Bonnabry, P; Dayer, P; Leemann, T | 1 |
Gelboin, HV; Gonzalez, FJ; Krausz, KW; Shou, M; Yang, TJ | 1 |
Ekins, S; Lawton, MP; Mankowski, DC | 1 |
Ayrton, AD; Chenery, R; Clarke, SE; Deeni, YY; Paine, MJ; Wolf, CR | 1 |
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K | 1 |
Crespi, C; Gaedigk, A; Leeder, JS; Marcucci, KA; Pearce, RE; Steimel, DT | 1 |
Lin, Y; Mei, Q; Rushmore, TH; Shou, M; Tang, C | 1 |
Chiba, K; Hosokawa, M; Kobayashi, K; Shiraishi, T; Taguchi, M; Tainaka, H; Yamaura, Y | 1 |
Friis, C; Skaanild, MT | 1 |
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y | 1 |
Abdel-Rahman, SM; Alander, SW; Bhathena, A; Bradford, LD; Gaedigk, A; Leeder, JS; Ndjountché, L; Pearce, RE; Rogan, PK | 1 |
Bonifacio, A; Commandeur, JN; Gooijer, C; Keizers, PH; Robert, B; van der Zwan, G; Vermeulen, NP | 1 |
Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA | 1 |
Hiratsuka, M; Ishikawa, M; Mizugaki, M; Obata, K; Sakuyama, K; Sasaki, T; Ujiie, S | 1 |
Funae, Y; Hanioka, N; Katsu, T; Kazamori, D; Masuda, K; Naito, S; Nakura, H; Narimatsu, S; Yamano, S | 1 |
Kohara, S; Murayama, N; Uehara, S; Uno, Y; Yamazaki, H | 2 |
Agrawal, V; Giacomini, KM; Kramer, MA; Miller, WL; Morrissey, K; Sandee, D; Tam, HK; Tracy, TS | 1 |
Cai, J; Cai, JP; Dai, DP; Geng, PW; Hu, GX; Hu, JH; Hu, LM; Nie, JJ; Wang, SH | 1 |
Kohara, S; Murayama, N; Osada, N; Uehara, S; Uno, Y; Yamazaki, H | 1 |
Hagihira, Y; Inoue, T; Murayama, N; Sasaki, E; Shimizu, M; Uehara, S; Uno, Y; Yamazaki, H | 1 |
Cai, J; Cai, JP; Dai, DP; Geng, PW; Hu, GX; Huang, XX; Wang, H; Wang, SH; Zhan, YY | 1 |
Cho, C; Fujiwara, R; Furge, LL; Glass, SM; Glista, MJ; Hicks, MJ; Kamath, SS; Martell, CM; Mills, JM; Osorio-Vasquez, V; Oswalt, AK | 1 |
Don, CG; Smieško, M | 1 |
33 other study(ies) available for bufuralol and dextromethorphan
Article | Year |
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Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation.
Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Kinetics; Microsomes, Liver; Research Design; Tandem Mass Spectrometry | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6.
Topics: Adrenergic beta-Antagonists; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Ethanolamines; Humans; Microsomes, Liver; Mixed Function Oxygenases; Spectrometry, Fluorescence; Substrate Specificity | 1991 |
Potent inhibition of cytochrome P450IID6 (debrisoquin 4-hydroxylase) by flecainide in vitro and in vivo.
Topics: Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Debrisoquin; Dextromethorphan; Ethanolamines; Flecainide; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenotype; Sparteine | 1990 |
Cytochrome P450IID subfamily in non-human primates. Catalytical and immunological characterization.
Topics: Animals; Autoantibodies; Binding, Competitive; Cross Reactions; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Ethanolamines; Humans; Isoenzymes; Kinetics; Macaca fascicularis; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating | 1991 |
Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity.
Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dealkylation; Dextromethorphan; Ethanolamines; Humans; In Vitro Techniques; Kinetics; Levorphanol; Microsomes, Liver; Mixed Function Oxygenases; Polymorphism, Genetic | 1989 |
High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Ethanolamines; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, O-Demethylating; Polymorphism, Genetic | 1987 |
Selective inhibition of major drug metabolizing cytochrome P450 isozymes in human liver microsomes by carbon monoxide.
Topics: Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating | 1994 |
A monoclonal antibody inhibitory to human P450 2D6: a paradigm for use in combinatorial determination of individual P450 role in specific drug tissue metabolism.
Topics: Animals; Antibodies, Monoclonal; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Ethanolamines; Humans; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mixed Function Oxygenases; Phenanthrenes; Tissue Distribution | 1997 |
Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Intestines; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Obese; Mice, Transgenic; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Testosterone | 2000 |
Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.
Topics: Cytochrome P-450 CYP2D6; Dextromethorphan; Escherichia coli; Ethanolamines; Humans; Metoprolol; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Protein Engineering; Recombinant Fusion Proteins; Technology, Pharmaceutical | 2001 |
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured | 2002 |
Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Topics: Animals; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Ethanolamines; Genetic Variation; Insecta; Kinetics; Phenotype; Substrate Specificity; Transfection | 2002 |
Inhibition kinetics of monoclonal antibodies against cytochromes P450.
Topics: Aflatoxins; Animals; Antibodies, Monoclonal; Antibody Specificity; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Ethanolamines; Humans; Hybridomas; Hydroxylation; Immunoglobulin G; In Vitro Techniques; Isoenzymes; Kinetics; Macaca mulatta; Mice; Microsomes, Liver; Models, Biological; Rats; Species Specificity; Testosterone | 2002 |
Effects of G169R and P34S substitutions produced by mutations of CYP2D6*14 on the functional properties of CYP2D6 expressed in V79 cells.
Topics: Alleles; Amino Acid Substitution; Animals; Cell Line; Cricetinae; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dealkylation; Dextromethorphan; DNA, Complementary; Ethanolamines; Gene Expression Regulation, Enzymologic; Hydroxylation; Mutation; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Steroid 21-Hydroxylase | 2002 |
Is cytochrome P450 CYP2D activity present in pig liver?
Topics: Animals; Antibodies, Monoclonal; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Ethanolamines; Female; Male; Microsomes, Liver; Substrate Specificity; Swine; Swine, Miniature | 2002 |
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone | 2004 |
Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Topics: Alleles; Black or African American; Cloning, Molecular; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Female; Gene Expression; Gene Frequency; Genes, Reporter; Genetic Variation; Genotype; Haplotypes; Humans; Liver; Luciferases; Phenotype; Polymorphism, Single Nucleotide; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Splicing; Tramadol; Transcription, Genetic | 2005 |
Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy.
Topics: Amino Acid Substitution; Binding Sites; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Heme; Humans; Mutation; N-Methyl-3,4-methylenedioxyamphetamine; Spectrum Analysis, Raman | 2006 |
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol | 2007 |
Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).
Topics: Animals; Catalysis; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Humans; Japan; Kinetics; Microsomes; Polymorphism, Genetic; Transfection | 2008 |
The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cytochrome P-450 CYP2D6; Dextromethorphan; DNA Primers; Ethanolamines; Humans; Kinetics; Male; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Substrate Specificity | 2009 |
Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cytochrome P-450 Enzyme System; Dextromethorphan; DNA Primers; DNA, Complementary; Ethanolamines; Exons; Introns; Macaca fascicularis; Molecular Sequence Data; Open Reading Frames; RNA, Messenger; Sequence Homology, Amino Acid | 2010 |
Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.
Topics: Benzopyrans; Catalysis; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Genetic Variation; Humans; Inactivation, Metabolic; Mutation; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Polymorphism, Genetic | 2010 |
Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism.
Topics: Animals; Cytochrome P-450 Enzyme System; Dextromethorphan; Escherichia coli; Ethanolamines; Genetic Variation; Genotype; Hydroxylation; Macaca fascicularis; Macaca mulatta; Microsomes, Liver; Polymorphism, Genetic | 2014 |
In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.
Topics: Asian People; China; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Gene Frequency; Genotype; HEK293 Cells; Humans; Mutation; Phenotype; Substrate Specificity; Transfection | 2015 |
CYP2D44 polymorphisms in cynomolgus and rhesus macaques.
Topics: Animals; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Ethanolamines; Gene Expression; Genotype; Humans; Hydroxylation; Liver; Macaca fascicularis; Macaca mulatta; Models, Molecular; Mutagenesis, Site-Directed; Polymorphism, Genetic; Sequence Homology, Amino Acid | 2015 |
Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan.
Topics: Amino Acid Sequence; Animals; Callithrix; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; DNA, Complementary; Ethanolamines; Exons; Gene Expression Regulation, Enzymologic; Humans; Intestine, Small; Introns; Isoenzymes; Kinetics; Liver; Metoprolol; Molecular Sequence Data; Multigene Family; Organ Specificity; Oxidation-Reduction; Phylogeny; Recombinant Proteins; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2015 |
Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro.
Topics: Alleles; Animals; Asian People; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Gene Expression Regulation; Genetic Variation; Humans; Insecta; Microsomes | 2016 |
CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712.
Topics: Alleles; Catalytic Domain; Cytochrome P-450 CYP2D6; Dextromethorphan; Ethanolamines; Humans; Imidazoles; Inactivation, Metabolic; Kinetics; Mutation; NADP; Phenotype; Pyrimidines | 2018 |
Microsecond MD simulations of human CYP2D6 wild-type and five allelic variants reveal mechanistic insights on the function.
Topics: Alleles; Benzimidazoles; Catalytic Domain; Cytochrome P-450 CYP2D6; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Heme; Humans; Hydrogen Bonding; Inactivation, Metabolic; Molecular Dynamics Simulation; Substrate Specificity; Tamoxifen | 2018 |