bufalin and cinobufagin

bufalin has been researched along with cinobufagin in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.33)18.7374
1990's8 (26.67)18.2507
2000's11 (36.67)29.6817
2010's7 (23.33)24.3611
2020's3 (10.00)2.80

Authors

AuthorsStudies
Kamano, Y; Nogawa, T; Pettit, GR; Yamashita, A1
Ball, WJ; Farr, CD; Fishwild, DM; Nair, AC; Tabet, MR; Wang, X; Welsh, WJ1
Itokawa, H; Kamano, Y; Katsuyama, M; Morita, H; Nogawa, T; Pettit, GR; Saito, K; Segawa, T; Takeya, K; Yamashita, A; Yukita, A1
Enomoto, A; Hayashi, M; Komiyama, K; Rho, MC1
Liu, JH; Sun, Y; Xu, Q; Yu, BY; Zhang, J1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Chen, L; Chen, W; Deng, L; Fan, C; Li, Y; Liu, J; Liu, S; Luo, H; Ruan, Z; Tian, H; Wang, L; Wang, Y; Xiao, G; Ye, W; Yiu, A; Zhang, D1
Jiang, RW; Liu, JS; Luo, SL; Tian, HY; Wang, L; Wang, Y; Ye, WC; Zhang, DM; Zhang, XQ1
Kuroiwa, Y; Nakaya, K; Yoshida, T; Zhang, L1
Hirai, Y; Ito, C; Morishita, S; Sakanashi, M1
Chan, K; Hong, Z; Yeung, HW1
Hirai, Y; Horie, M; Ito, C; Morishita, S; Oguni, Y; Shoji, M; Sugimoto, C; Toma, S1
Kuroiwa, Y; Nakaya, K; Yoshida, T; Zhang, LS1
Bania, T; Brubacher, JR; Heller, MB; Hoffman, RS; Ravikumar, PR1
Morishita, S; Shimizu, Y1
Chen, Y; Gu, W; Xiang, J; Xu, M1
Huang, WJ; Kan, SF; Wang, PS; Yeh, JY1
Niu, X; Su, YH; Yang, XZ1
ANDERSON, RC; CHEN, KK; HENDERSON, FG1
Guo, D; Ye, M1
Feng, JF; Liu, D1
Jea Chien, E; Kan, SF; Pu, HF; Wang, PS; Yu, CH1
Byard, RW; Kostakis, C1
Jin, H; Xia, X; Yan, S; Zhang, W1
Cui, J; Liu, J; Lv, L; Ma, XC; Wang, CY; Wei, Q; Xin, XL; Yao, JH1
Cui, X; Gao, B; Inagaki, Y; Kokudo, N; Li, A; Qi, F; Tang, W; Xu, H1
Kau, MM; Tsai, SC; Wang, JR; Wang, PS; Yu, CH1
Cai, Z; Chen, Y; Chen, Z; Hong, Y; Jiang, L; Liu, L; Wu, Y; Yi, X; Zhang, J1
Dall'Oglio, EL; de Jesus Rodrigues, D; de Vasconcelos, LG; Kerkhoff, J; Sinhorin, AP; Sinhorin, VDG1
Lian, X; Shu, C; Wu, Y; Yi, X; Zhang, J; Zhu, J1

Other Studies

30 other study(ies) available for bufalin and cinobufagin

ArticleYear
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.
    Journal of natural products, 2001, Volume: 64, Issue:9

    Topics: Animals; Antineoplastic Agents; Bufanolides; Bufonidae; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; HL-60 Cells; Humans; KB Cells; Leukemia, Myeloid; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Mice; Molecular Conformation; Molecular Structure; Nasopharyngeal Neoplasms; Skin; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured

2001
Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis.
    Journal of medicinal chemistry, 2002, Jul-18, Volume: 45, Issue:15

    Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Binding, Competitive; Carbohydrate Sequence; Digoxin; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin Fab Fragments; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Ouabain; Progesterone; Quantitative Structure-Activity Relationship; Radioligand Assay

2002
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).
    Journal of medicinal chemistry, 2002, Dec-05, Volume: 45, Issue:25

    Topics: Antineoplastic Agents; Bufanolides; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Models, Molecular; Quantitative Structure-Activity Relationship; Tumor Cells, Cultured

2002
Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells.
    Journal of natural products, 2004, Volume: 67, Issue:12

    Topics: Animals; Bufanolides; Bufo bufo; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Interleukin-6; Mice; Molecular Structure; Stereoisomerism; Tumor Cells, Cultured

2004
Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure-activity relationship (SAR).
    Bioorganic & medicinal chemistry letters, 2007, Nov-15, Volume: 17, Issue:22

    Topics: Acetylation; Antineoplastic Agents; Biotransformation; Bufanolides; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Nocardia; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Structure-Activity Relationship

2007
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities.
    Journal of medicinal chemistry, 2013, Jul-25, Volume: 56, Issue:14

    Topics: Animals; Antineoplastic Agents; Apoptosis; Bufanolides; Chloride Channels; Drug Discovery; Humans; Mice; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship; TOR Serine-Threonine Kinases

2013
C23 steroids from the venom of Bufo bufo gargarizans.
    Journal of natural products, 2013, Oct-25, Volume: 76, Issue:10

    Topics: Amphibian Venoms; Animals; Antineoplastic Agents; Bufanolides; Bufo bufo; China; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred Strains; Molecular Structure; Sodium-Potassium-Exchanging ATPase; Spleen; Structure-Activity Relationship

2013
Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia cells in combination with other inducers.
    Cancer research, 1992, Sep-01, Volume: 52, Issue:17

    Topics: Antineoplastic Agents; Bufanolides; Cell Differentiation; Cell Division; Cytokines; Digitoxigenin; Drug Administration Schedule; Drug Synergism; Humans; In Vitro Techniques; Leukemia, Myeloid; Macrophages; Monocytes; Ouabain; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured; Vitamins

1992
[Effects of bufadienolides and some kinds of cardiotonics on guinea pig hearts].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1992, Volume: 100, Issue:2

    Topics: Action Potentials; Animals; Bufanolides; Cardiotonic Agents; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Sodium-Potassium-Exchanging ATPase

1992
Simultaneous determination of bufadienolides in the traditional Chinese medicine preparation, liu-shen-wan, by liquid chromatography.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:12

    Topics: Bufanolides; Cardiotonic Agents; Chromatography, High Pressure Liquid; Medicine, Chinese Traditional

1992
[Metabolic fate of bufalin and cinobufagin].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1991, Volume: 111, Issue:11

    Topics: Administration, Oral; Animals; Bile; Bufanolides; Depression, Chemical; Guinea Pigs; In Vitro Techniques; Injections, Intravenous; Liver; Male; Myocardium; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase

1991
Bufalin as a potent inducer of differentiation of human myeloid leukemia cells.
    Biochemical and biophysical research communications, 1991, Jul-31, Volume: 178, Issue:2

    Topics: Bufanolides; Cell Differentiation; Cell Line; Digitoxigenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Materia Medica; Molecular Structure; Ouabain

1991
Treatment of toad venom poisoning with digoxin-specific Fab fragments.
    Chest, 1996, Volume: 110, Issue:5

    Topics: Adolescent; Adult; Amphibian Venoms; Animals; Aphrodisiacs; Bradycardia; Bufanolides; Bufonidae; Bufotenin; Digoxin; Fatal Outcome; Humans; Immunoglobulin Fab Fragments; Male; Materia Medica; Ventricular Fibrillation; Vomiting

1996
Metabolism and disposition of kyushin, a drug containing senso (ch'an su).
    The American journal of Chinese medicine, 1996, Volume: 24, Issue:3-4

    Topics: Bufanolides; Cardiotonic Agents; Humans; Male; Medicine, Chinese Traditional

1996
[Chemical constituents of Bufo Siccus].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1998, Volume: 23, Issue:10

    Topics: Animals; Bufanolides; Bufo bufo; Materia Medica; Molecular Structure

1998
Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells.
    The Prostate, 2003, Feb-01, Volume: 54, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Bufanolides; Calcium; Cell Division; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Male; Materia Medica; Prostatic Neoplasms; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured

2003
[Dynamic effect of low frequency complex impulse current on transdermal absorption of secretio bufonis].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2003, Volume: 23, Issue:10

    Topics: Animals; Bufanolides; Bufonidae; Chromatography, High Pressure Liquid; Electric Stimulation; Iontophoresis; Male; Materia Medica; Rabbits; Skin Absorption

2003
Comparison of cardiac action of bufalin, cinobufotalin, and telocinobufagin with cinobufagin.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1951, Volume: 76, Issue:2

    Topics: Animals; Anura; Bufanolides; Bufonidae; Digitalis; Digitalis Glycosides; Heart; Hedera; Venoms

1951
Substrate specificity for the 12beta-hydroxylation of bufadienolides by Alternaria alternata.
    Journal of biotechnology, 2005, May-25, Volume: 117, Issue:3

    Topics: Alternaria; Biotransformation; Bufanolides; Cholenes; Chromatography, High Pressure Liquid; Hydroxylation; Kinetics; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity

2005
[Determination of apparent aqueous solubility and apparent oil-water partition coefficients of three bufadienolides composition].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:11

    Topics: Bufanolides; Calibration; Hydrogen-Ion Concentration; Logistic Models; Oils; Solubility; Temperature; Water

2008
Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells.
    Cancer science, 2008, Volume: 99, Issue:12

    Topics: Androgens; Apoptosis; bcl-2-Associated X Protein; Bufanolides; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; fas Receptor; Fluorescent Antibody Technique, Indirect; Formazans; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Tumor Suppressor Protein p53

2008
Sudden death associated with intravenous injection of toad extract.
    Forensic science international, 2009, Jul-01, Volume: 188, Issue:1-3

    Topics: Amphibian Venoms; Animals; Anura; Bufanolides; Bufotenin; Death, Sudden; Forensic Toxicology; Hallucinogens; Humans; Illicit Drugs; Injections, Intravenous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Young Adult

2009
Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection.
    Journal of pharmaceutical and biomedical analysis, 2010, Nov-02, Volume: 53, Issue:3

    Topics: Animals; Bufanolides; Chromatography, High Pressure Liquid; Male; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization

2010
Preparative separation of four major bufadienolides from the Chinese traditional medicine, Chansu, using high-speed counter-current chromatography.
    Natural product communications, 2010, Volume: 5, Issue:7

    Topics: Bufanolides; Chromatography, High Pressure Liquid; Countercurrent Distribution; Drugs, Chinese Herbal; Molecular Structure

2010
Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways.
    Cancer science, 2011, Volume: 102, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Mitochondria; Signal Transduction

2011
Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells.
    British journal of pharmacology, 2012, Volume: 165, Issue:6

    Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Bufanolides; Butadienes; Cardiotonic Agents; Cell Line; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Enzyme Inhibitors; Humans; Hydrocortisone; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphoproteins; Steroidogenic Factor 1

2012
Global Metabolomic and Lipidomic Analysis Reveal the Synergistic Effect of Bufalin in Combination with Cinobufagin against HepG2 Cells.
    Journal of proteome research, 2020, 02-07, Volume: 19, Issue:2

    Topics: Bufanolides; Hep G2 Cells; Lipidomics; Medicine, Chinese Traditional

2020
Chemical profile of the parotoid gland secretion of the Amazonian toad (Rhinella margaritifera).
    Toxicon : official journal of the International Society on Toxinology, 2020, Jul-30, Volume: 182

    Topics: Amphibian Venoms; Animals; Bufanolides; Bufonidae; Cell Line, Tumor; Chromatography, High Pressure Liquid; Parotid Gland

2020
Response Surface Methodology to Optimize the Combination Treatment of Paclitaxel, Bufalin and Cinobufagin for Hepatoma Therapy.
    Combinatorial chemistry & high throughput screening, 2021, Volume: 24, Issue:10

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bufanolides; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Conformation; Paclitaxel; Surface Properties; Tumor Cells, Cultured

2021