bufalin has been researched along with cinobufagin in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 8 (26.67) | 18.2507 |
| 2000's | 11 (36.67) | 29.6817 |
| 2010's | 7 (23.33) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamano, Y; Nogawa, T; Pettit, GR; Yamashita, A | 1 |
| Ball, WJ; Farr, CD; Fishwild, DM; Nair, AC; Tabet, MR; Wang, X; Welsh, WJ | 1 |
| Itokawa, H; Kamano, Y; Katsuyama, M; Morita, H; Nogawa, T; Pettit, GR; Saito, K; Segawa, T; Takeya, K; Yamashita, A; Yukita, A | 1 |
| Enomoto, A; Hayashi, M; Komiyama, K; Rho, MC | 1 |
| Liu, JH; Sun, Y; Xu, Q; Yu, BY; Zhang, J | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Chen, L; Chen, W; Deng, L; Fan, C; Li, Y; Liu, J; Liu, S; Luo, H; Ruan, Z; Tian, H; Wang, L; Wang, Y; Xiao, G; Ye, W; Yiu, A; Zhang, D | 1 |
| Jiang, RW; Liu, JS; Luo, SL; Tian, HY; Wang, L; Wang, Y; Ye, WC; Zhang, DM; Zhang, XQ | 1 |
| Kuroiwa, Y; Nakaya, K; Yoshida, T; Zhang, L | 1 |
| Hirai, Y; Ito, C; Morishita, S; Sakanashi, M | 1 |
| Chan, K; Hong, Z; Yeung, HW | 1 |
| Hirai, Y; Horie, M; Ito, C; Morishita, S; Oguni, Y; Shoji, M; Sugimoto, C; Toma, S | 1 |
| Kuroiwa, Y; Nakaya, K; Yoshida, T; Zhang, LS | 1 |
| Bania, T; Brubacher, JR; Heller, MB; Hoffman, RS; Ravikumar, PR | 1 |
| Morishita, S; Shimizu, Y | 1 |
| Chen, Y; Gu, W; Xiang, J; Xu, M | 1 |
| Huang, WJ; Kan, SF; Wang, PS; Yeh, JY | 1 |
| Niu, X; Su, YH; Yang, XZ | 1 |
| ANDERSON, RC; CHEN, KK; HENDERSON, FG | 1 |
| Guo, D; Ye, M | 1 |
| Feng, JF; Liu, D | 1 |
| Jea Chien, E; Kan, SF; Pu, HF; Wang, PS; Yu, CH | 1 |
| Byard, RW; Kostakis, C | 1 |
| Jin, H; Xia, X; Yan, S; Zhang, W | 1 |
| Cui, J; Liu, J; Lv, L; Ma, XC; Wang, CY; Wei, Q; Xin, XL; Yao, JH | 1 |
| Cui, X; Gao, B; Inagaki, Y; Kokudo, N; Li, A; Qi, F; Tang, W; Xu, H | 1 |
| Kau, MM; Tsai, SC; Wang, JR; Wang, PS; Yu, CH | 1 |
| Cai, Z; Chen, Y; Chen, Z; Hong, Y; Jiang, L; Liu, L; Wu, Y; Yi, X; Zhang, J | 1 |
| Dall'Oglio, EL; de Jesus Rodrigues, D; de Vasconcelos, LG; Kerkhoff, J; Sinhorin, AP; Sinhorin, VDG | 1 |
| Lian, X; Shu, C; Wu, Y; Yi, X; Zhang, J; Zhu, J | 1 |
30 other study(ies) available for bufalin and cinobufagin
| Article | Year |
|---|---|
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.
Topics: Animals; Antineoplastic Agents; Bufanolides; Bufonidae; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; HL-60 Cells; Humans; KB Cells; Leukemia, Myeloid; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Mice; Molecular Conformation; Molecular Structure; Nasopharyngeal Neoplasms; Skin; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured | 2001 |
Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Binding, Competitive; Carbohydrate Sequence; Digoxin; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin Fab Fragments; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Ouabain; Progesterone; Quantitative Structure-Activity Relationship; Radioligand Assay | 2002 |
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).
Topics: Antineoplastic Agents; Bufanolides; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Models, Molecular; Quantitative Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells.
Topics: Animals; Bufanolides; Bufo bufo; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Interleukin-6; Mice; Molecular Structure; Stereoisomerism; Tumor Cells, Cultured | 2004 |
Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure-activity relationship (SAR).
Topics: Acetylation; Antineoplastic Agents; Biotransformation; Bufanolides; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Nocardia; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Structure-Activity Relationship | 2007 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bufanolides; Chloride Channels; Drug Discovery; Humans; Mice; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship; TOR Serine-Threonine Kinases | 2013 |
C23 steroids from the venom of Bufo bufo gargarizans.
Topics: Amphibian Venoms; Animals; Antineoplastic Agents; Bufanolides; Bufo bufo; China; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred Strains; Molecular Structure; Sodium-Potassium-Exchanging ATPase; Spleen; Structure-Activity Relationship | 2013 |
Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia cells in combination with other inducers.
Topics: Antineoplastic Agents; Bufanolides; Cell Differentiation; Cell Division; Cytokines; Digitoxigenin; Drug Administration Schedule; Drug Synergism; Humans; In Vitro Techniques; Leukemia, Myeloid; Macrophages; Monocytes; Ouabain; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured; Vitamins | 1992 |
[Effects of bufadienolides and some kinds of cardiotonics on guinea pig hearts].
Topics: Action Potentials; Animals; Bufanolides; Cardiotonic Agents; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Sodium-Potassium-Exchanging ATPase | 1992 |
Simultaneous determination of bufadienolides in the traditional Chinese medicine preparation, liu-shen-wan, by liquid chromatography.
Topics: Bufanolides; Cardiotonic Agents; Chromatography, High Pressure Liquid; Medicine, Chinese Traditional | 1992 |
[Metabolic fate of bufalin and cinobufagin].
Topics: Administration, Oral; Animals; Bile; Bufanolides; Depression, Chemical; Guinea Pigs; In Vitro Techniques; Injections, Intravenous; Liver; Male; Myocardium; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase | 1991 |
Bufalin as a potent inducer of differentiation of human myeloid leukemia cells.
Topics: Bufanolides; Cell Differentiation; Cell Line; Digitoxigenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Materia Medica; Molecular Structure; Ouabain | 1991 |
Treatment of toad venom poisoning with digoxin-specific Fab fragments.
Topics: Adolescent; Adult; Amphibian Venoms; Animals; Aphrodisiacs; Bradycardia; Bufanolides; Bufonidae; Bufotenin; Digoxin; Fatal Outcome; Humans; Immunoglobulin Fab Fragments; Male; Materia Medica; Ventricular Fibrillation; Vomiting | 1996 |
Metabolism and disposition of kyushin, a drug containing senso (ch'an su).
Topics: Bufanolides; Cardiotonic Agents; Humans; Male; Medicine, Chinese Traditional | 1996 |
[Chemical constituents of Bufo Siccus].
Topics: Animals; Bufanolides; Bufo bufo; Materia Medica; Molecular Structure | 1998 |
Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Bufanolides; Calcium; Cell Division; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Male; Materia Medica; Prostatic Neoplasms; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured | 2003 |
[Dynamic effect of low frequency complex impulse current on transdermal absorption of secretio bufonis].
Topics: Animals; Bufanolides; Bufonidae; Chromatography, High Pressure Liquid; Electric Stimulation; Iontophoresis; Male; Materia Medica; Rabbits; Skin Absorption | 2003 |
Comparison of cardiac action of bufalin, cinobufotalin, and telocinobufagin with cinobufagin.
Topics: Animals; Anura; Bufanolides; Bufonidae; Digitalis; Digitalis Glycosides; Heart; Hedera; Venoms | 1951 |
Substrate specificity for the 12beta-hydroxylation of bufadienolides by Alternaria alternata.
Topics: Alternaria; Biotransformation; Bufanolides; Cholenes; Chromatography, High Pressure Liquid; Hydroxylation; Kinetics; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity | 2005 |
[Determination of apparent aqueous solubility and apparent oil-water partition coefficients of three bufadienolides composition].
Topics: Bufanolides; Calibration; Hydrogen-Ion Concentration; Logistic Models; Oils; Solubility; Temperature; Water | 2008 |
Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells.
Topics: Androgens; Apoptosis; bcl-2-Associated X Protein; Bufanolides; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; fas Receptor; Fluorescent Antibody Technique, Indirect; Formazans; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Tumor Suppressor Protein p53 | 2008 |
Sudden death associated with intravenous injection of toad extract.
Topics: Amphibian Venoms; Animals; Anura; Bufanolides; Bufotenin; Death, Sudden; Forensic Toxicology; Hallucinogens; Humans; Illicit Drugs; Injections, Intravenous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Young Adult | 2009 |
Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection.
Topics: Animals; Bufanolides; Chromatography, High Pressure Liquid; Male; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2010 |
Preparative separation of four major bufadienolides from the Chinese traditional medicine, Chansu, using high-speed counter-current chromatography.
Topics: Bufanolides; Chromatography, High Pressure Liquid; Countercurrent Distribution; Drugs, Chinese Herbal; Molecular Structure | 2010 |
Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Mitochondria; Signal Transduction | 2011 |
Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Bufanolides; Butadienes; Cardiotonic Agents; Cell Line; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Enzyme Inhibitors; Humans; Hydrocortisone; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphoproteins; Steroidogenic Factor 1 | 2012 |
Global Metabolomic and Lipidomic Analysis Reveal the Synergistic Effect of Bufalin in Combination with Cinobufagin against HepG2 Cells.
Topics: Bufanolides; Hep G2 Cells; Lipidomics; Medicine, Chinese Traditional | 2020 |
Chemical profile of the parotoid gland secretion of the Amazonian toad (Rhinella margaritifera).
Topics: Amphibian Venoms; Animals; Bufanolides; Bufonidae; Cell Line, Tumor; Chromatography, High Pressure Liquid; Parotid Gland | 2020 |
Response Surface Methodology to Optimize the Combination Treatment of Paclitaxel, Bufalin and Cinobufagin for Hepatoma Therapy.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bufanolides; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Conformation; Paclitaxel; Surface Properties; Tumor Cells, Cultured | 2021 |