budipine has been researched along with piperidines in 46 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 12 (26.09) | 18.7374 |
1990's | 19 (41.30) | 18.2507 |
2000's | 13 (28.26) | 29.6817 |
2010's | 2 (4.35) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Henning, K; Pindur, U; Przuntek, H; Russ, H | 1 |
Dimpfel, W; Menge, HG; Spüler, M | 1 |
Przuntek, H; Russ, H | 1 |
Pindur, U; Przuntek, H; Russ, H | 1 |
Mihatsch, W; Przuntek, H; Russ, H | 1 |
Bliesath, H; Jellinger, K | 1 |
Kohlhepp, W; Krüger, H; Przuntek, H; Reimann, G | 1 |
Fischer, R; Iizuka, J | 1 |
Eistetter, K; Hackmack, G; Klosa, J; Krüger, U; Menge, HG; Schaefer, H | 1 |
Eltze, M | 2 |
Brand, U; Menge, HG | 1 |
Feuerstein, TJ; Hertting, G; Jackisch, R; Kruchen, A; Sauermann, W | 1 |
Huang, HY; Jackisch, R; Limberger, N; Reimann, W | 1 |
Jacobsen, P; Klockgether, T; Löschmann, PA; Turski, L | 1 |
Boose, A; Dichgans, J; Jentgens, C; Klockgether, T; Löschmann, P; Spieker, S | 1 |
Klockgether, T; Löschmann, PA; Petersen, V; Steinbach, JP; Turski, L; Wüllner, U | 1 |
Herr, B; Kornhuber, J; Riederer, P; Thome, J | 1 |
Balster, RF; Joharchi, N; Li, NY; Otton, SV; Sellers, EM; Tomkins, DM; Tyndale, RF | 1 |
Allard, P; Norlén, M | 1 |
Hartmann, S; Parsons, CG; Spielmanns, P | 1 |
Biggs, CS; Fisher, A; Starr, MS | 1 |
Berns, T; Corrigall, WA; Joharchi, N; Otton, SV; Sellers, EM; Tomkins, DM; Wu, D | 1 |
Klockgether, T; Löschmann, PA; Spieker, S | 1 |
Müller, T; Przuntek, H | 1 |
Breit, S; Dichgans, J; Klockgether, T; Spieker, S | 1 |
France, CP; Lelas, S; Otton, SV; Sellers, EM; Wegert, S | 1 |
Biggs, CS; Starr, MS | 1 |
Ghaemi, M; Rudolf, J; Schmülling, S | 1 |
Bliesath, H; Böther, K; Lühmann, R; Malsch, U; Ramm, H | 1 |
Müller, T | 1 |
Bethke, TH; Hauschke, D; Heinze, H; Merz, M; Seiberling, M; Wurst, W; Zech, K | 1 |
Bittkau, S; Bliesath, H; Büttner, U; Fuchs, G; Glass, J; Haller, H; Klockgether, T; Kraus, P; Lachenmayer, L; Müller, D; Müller, T; Przuntek, H; Rathay, B; Sgonina, J; Steinijans, V; Teshmar, E; Ulm, G; Volc, D | 1 |
Karle, CA; Kathöfer, S; Katus, HA; Kiehn, J; Kiesecker, C; Kreye, VA; Lueck, S; Peth, S; Schoels, W; Scholz, EP; Thomas, D; Weretka, S; Zitron, E | 1 |
Ceballos-Baumann, A | 1 |
Krüger, R; Mackowiak, A; Müller, T; Przuntek, H | 1 |
Cock, HR; Fisher, A; Patsalos, PN; Thom, M; Walker, MC; Wang, X | 1 |
Kuhn, W; Müller, T; Przuntek, H | 1 |
Owen, JC; Whitton, PS | 2 |
Ludolph, A; Odin, P; Oehlwein, C; Polzer, U; Renner, R; Schüler, P; Shing, M; Storch, A; Werner, G | 1 |
Reichmann, H | 1 |
Büttner, T; Csoti, I; Kassubek, J; Reichmann, H; Riederer, P; Schulz, JB; Wüllner, U | 1 |
Lettow, I; Röther, J | 1 |
6 review(s) available for budipine and piperidines
Article | Year |
---|---|
Clinical efficacy of budipine in Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Clinical Trials as Topic; Humans; Parkinson Disease; Piperidines | 1999 |
Multiple mechanisms of action: the pharmacological profile of budipine.
Topics: Animals; Antiparkinson Agents; Brain Chemistry; Humans; Neurotransmitter Agents; Piperidines; Receptors, Neurotransmitter | 1999 |
Non-dopaminergic drug treatment of Parkinson's disease.
Topics: Adenosine; Adrenergic alpha-Antagonists; Body Weight; Cholinergic Antagonists; Homocysteine; Humans; Levodopa; Methionine; N-Methylaspartate; Parkinson Disease; Piperidines; Serotonin Receptor Agonists | 2001 |
[Diagnosis and treatment of Parkinson's syndrome. What is important for the general practitioner?].
Topics: Aged; Amantadine; Antiparkinson Agents; Apomorphine; Botulinum Toxins; Catechols; Cholinesterase Inhibitors; Clinical Trials as Topic; Diagnosis, Differential; Dopamine Agents; Dopamine Agonists; Enzyme Inhibitors; Ergot Alkaloids; Family Practice; Female; Humans; Levodopa; Male; Nitriles; Parkinson Disease; Parkinson Disease, Secondary; Parkinsonian Disorders; Piperidines | 2003 |
Budipine in Parkinson's tremor.
Topics: Animals; Antiparkinson Agents; Humans; Parkinson Disease; Piperidines; Tremor | 2006 |
[On the role of MAO B inhibitors and NMDA antagonists in the therapy of Parkinson's disease].
Topics: Amantadine; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; N-Methylaspartate; Parkinson Disease; Piperidines; Selegiline | 2010 |
10 trial(s) available for budipine and piperidines
Article | Year |
---|---|
Adjuvant treatment of Parksinson's disease with budipine: a double-blind trial versus placebo.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Benserazide; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Piperidines | 1987 |
[Modification of Parkinson tremor by budipine. A comparative study with amantadine].
Topics: Adult; Aged; Amantadine; Antiparkinson Agents; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Piperidines; Random Allocation | 1986 |
Tremorlytic activity of budipine: a quantitative study with long-term tremor recordings.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Electromyography; Female; Humans; Male; Middle Aged; Parkinson Disease; Pilot Projects; Piperidines; Time Factors; Tremor | 1995 |
The NMDA antagonist budipine can alleviate levodopa-induced motor fluctuations.
Topics: Adult; Aged; Antiparkinson Agents; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; N-Methylaspartate; Parkinson Disease; Pilot Projects; Piperidines; Severity of Illness Index | 1999 |
Tremorlytic activity of budipine in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Double-Blind Method; Electromyography; Female; Humans; Levodopa; Male; Parkinson Disease; Piperidines; Tremor | 1999 |
[Monotherapy of Parkinson's disease with budipine. A double blind comparison with amantadine].
Topics: Aged; Aged, 80 and over; Amantadine; Antiparkinson Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Parkinson Disease; Piperidines | 2001 |
Dose linearity and steady state pharmacokinetics of the new antiparkinson agent budipine after oral administration.
Topics: Administration, Oral; Adult; Antiparkinson Agents; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Half-Life; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Piperidines | 2001 |
Budipine provides additional benefit in patients with Parkinson disease receiving a stable optimum dopaminergic drug regimen.
Topics: Adult; Aged; Antiparkinson Agents; Bromocriptine; Dopamine Agents; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Piperidines; Treatment Outcome | 2002 |
Efficacy of budipine and placebo in untreated patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Basal Ganglia; Disability Evaluation; Dopamine; Double-Blind Method; Female; Humans; Male; Middle Aged; Movement; Neurologic Examination; Parkinson Disease; Piperidines; Placebo Effect; Synaptic Transmission; Treatment Outcome | 2005 |
Efficacy and safety of high-dose cabergoline in Parkinson's disease.
Topics: Adolescent; Adult; Aged; Amantadine; Antiparkinson Agents; Cabergoline; Catechols; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Dystonia; Ergolines; Humans; Levodopa; Middle Aged; Nitriles; Parkinson Disease; Piperidines; Prospective Studies; Quality of Life; Selegiline; Severity of Illness Index; Treatment Outcome | 2006 |
30 other study(ies) available for budipine and piperidines
Article | Year |
---|---|
The protective effect of 1-tert.butyl-4,4-diphenylpiperidine against the nigrostriatal neurodegeneration caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Drug Interactions; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Piperidines; Pyridines; Rats; Rats, Inbred Strains; Serotonin | 1985 |
Effects of the antiparkinson drug budipine on EEG activity in unrestrained rats.
Topics: Animals; Antiparkinson Agents; Electroencephalography; Male; Parasympatholytics; Piperidines; Rats; Rats, Inbred F344; Telemetry | 1989 |
Budipine and the MPTP binding site.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Binding, Competitive; Humans; Parkinson Disease, Secondary; Piperidines; Pyridines; Rats; Receptors, Drug | 1985 |
The interaction of 1-alkyl-4,4-diphenylpiperidines with the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine receptor binding site.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Male; Neurotoxins; Piperidines; Pyridines; Pyridinium Compounds; Radioligand Assay; Rats; Rats, Inbred Lew; Receptors, Cholinergic; Synaptosomes | 1986 |
Intracerebroventricular administration of 1-methyl-4-phenylpyridinium ion in mice: effects of simultaneously administered nomifensine, deprenyl, and 1-t-butyl-4,4-diphenylpiperidine.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Catecholamines; Caudate Nucleus; Dose-Response Relationship, Drug; Drug Interactions; Female; Injections, Intraventricular; Male; Monoamine Oxidase Inhibitors; Movement Disorders; Nomifensine; Phenethylamines; Piperidines; Pyridinium Compounds; Selegiline; Serotonin | 1988 |
Prophylactic treatment of cluster headache with budipine.
Topics: Adolescent; Adult; Chronic Disease; Cluster Headache; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Piperidines; Vascular Headaches | 1988 |
[Therapeutic effect of budipin in treating Parkinson's disease].
Topics: Antiparkinson Agents; Female; Humans; Male; Middle Aged; Parkinson Disease; Piperidines | 1985 |
[Synthesis, physical-chemical properties and pharmacologically-oriented screening studies on budipine and related 4,4-diphenylpiperidines].
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Drug Evaluation, Preclinical; Lethal Dose 50; Magnetic Resonance Spectroscopy; Mice; Permeability; Piperidines; Reserpine; Salivation; Structure-Activity Relationship; Tremor | 1984 |
The effects of prodipine and budipine on 14C-5-hydroxytryptamine uptake and release by human blood platelets.
Topics: Adult; Antiparkinson Agents; Blood Platelets; Female; Humans; In Vitro Techniques; Kinetics; Male; Piperidines; Serotonin | 1980 |
[Summarizing description of the pharmacology of budipine, a new 4,4-diphenylpiperidine derivative used in Parkinson therapy (author's transl)].
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Biogenic Amines; Central Nervous System; Electroencephalography; Mice; Peripheral Nerves; Piperidines; Rats; Rats, Inbred Strains; Tremor | 1982 |
The antiparkinsonian drugs budipine and biperiden are use-dependent (uncompetitive) NMDA receptor antagonists.
Topics: Acetylcholine; Animals; Antiparkinson Agents; Binding, Competitive; Biperiden; Caudate Nucleus; Dizocilpine Maleate; In Vitro Techniques; Piperidines; Rabbits; Receptors, N-Methyl-D-Aspartate; Software | 1994 |
Effects of the antiparkinsonian drug budipine on neurotransmitter release in central nervous system tissue in vitro.
Topics: Acetylcholine; Animals; Antiparkinson Agents; Caudate Nucleus; Cerebral Cortex; Dopamine; Dopamine Agents; gamma-Aminobutyric Acid; In Vitro Techniques; Neurotransmitter Agents; Norepinephrine; Parasympatholytics; Piperidines; Rabbits; Receptors, GABA-A; Sympathomimetics | 1993 |
The antiparkinsonian agent budipine is an N-methyl-D-aspartate antagonist.
Topics: Amino Acids; Anesthesia; Animals; Antiparkinson Agents; Binding, Competitive; Brain Chemistry; H-Reflex; In Vitro Techniques; Male; Mice; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Seizures; Spinal Cord | 1993 |
Effects of the antiparkinsonian drug budipine on central neurotransmitter systems.
Topics: Animals; Antiparkinson Agents; Biperiden; Central Nervous System; Dopamine; Excitatory Amino Acid Antagonists; Male; Mice; Microdialysis; Muscarinic Antagonists; N-Methylaspartate; Neostriatum; Neurotransmitter Agents; Oxidopamine; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Rotation; Seizures; Stereotyped Behavior; Sympatholytics | 1996 |
The antiparkinsonian drug budipine binds to NMDA and sigma receptors in postmortem human brain tissue.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Autopsy; Female; Frontal Lobe; Humans; Male; Middle Aged; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1995 |
Effect of cytochrome P450 2D1 inhibition on hydrocodone metabolism and its behavioral consequences in rats.
Topics: Animals; Behavior, Animal; Brain; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Hydrocodone; Male; Piperidines; Quinine; Rats; Rats, Wistar; Self Administration | 1997 |
[3H]GBR 12935 binding in platelets: a possible association with cytochrome P-450IID6?
Topics: Antipsychotic Agents; Blood Platelets; Culture Techniques; Cytochrome P-450 Enzyme System; Dopamine Antagonists; Enzyme Inhibitors; Flupenthixol; Humans; Ligands; Lobeline; Piperazines; Piperidines; Quinidine | 1997 |
[Parkinson diseases--polyvalent therapy with Budipin].
Topics: Antiparkinson Agents; Humans; Parkinson Disease; Piperidines | 1998 |
Budipine is a low affinity, N-methyl-D-aspartate receptor antagonist: patch clamp studies in cultured striatal, hippocampal, cortical and superior colliculus neurones.
Topics: Amantadine; Animals; Antiparkinson Agents; Brain; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Hippocampus; Memantine; Neostriatum; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi | 1998 |
The antiparkinsonian drug budipine stimulates the activity of aromatic L-amino acid decarboxylase and enhances L-DOPA-induced dopamine release in rat substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Antiparkinson Agents; Aromatic-L-Amino-Acid Decarboxylases; Corpus Striatum; Dopamine; Drug Synergism; Kinetics; Levodopa; Male; Microdialysis; Piperidines; Rats; Rats, Wistar; Reserpine; Substantia Nigra; Time Factors | 1998 |
Effect of CYP2D1 inhibition on the behavioural effects of d-amphetamine.
Topics: Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Behavior, Animal; Central Nervous System Stimulants; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P450 Family 2; Dextroamphetamine; Discrimination, Psychological; Drug Interactions; Enzyme Inhibitors; Generalization, Stimulus; Male; Motor Activity; p-Hydroxyamphetamine; Piperidines; Quinine; Rats; Rats, Wistar; Self Administration | 1997 |
Inhibitors of cytochrome P450 differentially modify discriminative-stimulus and antinociceptive effects of hydrocodone and hydromorphone in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Discrimination Learning; Enzyme Inhibitors; Female; Hydrocodone; Hydromorphone; Macaca mulatta; Pain Measurement; Piperidines; Quinidine; Receptors, Opioid, mu | 1999 |
Microdialysis study of the effects of the antiparkinsonian drug budipine on L-DOPA-induced release of dopamine and 5-hydroxytryptamine by rat substantia nigra and corpus striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Levodopa; Male; Microdialysis; Piperidines; Rats; Rats, Wistar; Reserpine; Serotonin; Substantia Nigra; Tyrosine 3-Monooxygenase | 1999 |
Deterioration of parkinsonian symptoms following treatment of dopaminergic hallucinosis with olanzapine.
Topics: Aged; Antiparkinson Agents; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Drug Therapy, Combination; Hallucinations; Humans; Levodopa; Male; Olanzapine; Paranoid Disorders; Parkinson Disease; Piperidines; Pirenzepine; Selegiline; Severity of Illness Index | 1999 |
Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine.
Topics: Animals; Antiparkinson Agents; Binding Sites; Calcium Channels; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Guinea Pigs; In Vitro Techniques; Long QT Syndrome; Myocytes, Cardiac; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Time Factors; Xenopus laevis | 2003 |
Antiapoptotic effects of budipine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Apoptosis; Cell Line; Cell Line, Tumor; Humans; Interleukin-6; Piperidines; Sympathetic Nervous System; Tumor Necrosis Factor-alpha | 2004 |
Synergism between topiramate and budipine in refractory status epilepticus in the rat.
Topics: Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Fructose; Humans; Male; Neurons; Neuroprotective Agents; Perforant Pathway; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Status Epilepticus; Topiramate | 2004 |
Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats.
Topics: Amantadine; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antiparkinson Agents; Clomipramine; Drug Synergism; Male; Microdialysis; Paroxetine; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin | 2005 |
Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular dopamine in the frontal cortex of freely moving rats.
Topics: Amantadine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder; Dopamine; Drug Interactions; Excitatory Amino Acid Antagonists; Extracellular Fluid; Frontal Lobe; Glutamic Acid; Male; Microdialysis; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors; Up-Regulation | 2006 |
[Medical treatment of Parkinson's disease in elderly and multimorbid patients].
Topics: Aged, 80 and over; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Cholinergic Antagonists; Dopamine Agonists; Female; Humans; Levodopa; Male; Monoamine Oxidase Inhibitors; Parkinson Disease; Piperidines | 2014 |