bu 224 has been researched along with idazoxan in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baurin, N; Guillaumet, G; Marot, C; Mérour, JY; Morin-Allory, L; Payard, M; Renard, P; Vangrevelinghe, E | 1 |
| Conway, EL; Craven, JA | 1 |
| Diaz, A; Dickenson, AH; Mayet, S | 1 |
| Danbury, TC; Hudson, AL; Kestin, SC; Ruban, B; Waterman-Pearson, AE | 1 |
| Choi, DH; Choi, SH; Chun, BG; Lee, JJ; Park, MS | 1 |
| Finn, DP; Harbuz, MS; Hudson, AL; Jessop, DS; Lalies, MD; Nutt, DJ | 1 |
| Hudson, AL; Nutt, DJ; Robinson, ES; Tyacke, RJ | 1 |
| Coventry, TL; Finn, DP; Harbuz, MS; Hudson, AL; Jessop, DS; Kinoshita, H; Nutt, DJ | 1 |
| Hudson, AL; Hume, SP; Lalies, MD; Nutt, DJ; Robinson, ES; Tyacke, RJ | 1 |
| Handley, SL; MacInnes, N | 1 |
| Anderson, NJ; Hudson, AL; Lupo, PA; Nutt, DJ; Robinson, ES | 1 |
| Fukumura, T; Hatori, A; Higuchi, M; Kawamura, K; Maeda, J; Nagai, Y; Okauchi, T; Suhara, T; Zhang, MR | 1 |
| Li, JX; Winter, JC; Zhang, Y | 1 |
| Dai, H; Ding, T; Yan, M; Yu, L; Zhang, F; Zhong, Y | 1 |
| García-Sevilla, JA; Keller, B | 2 |
16 other study(ies) available for bu 224 and idazoxan
| Article | Year |
|---|---|
3D-QSAR CoMFA study on imidazolinergic I(2) ligands: a significant model through a combined exploration of structural diversity and methodology.
Topics: Drug Design; Imidazoles; Imidazoline Receptors; Ligands; Models, Molecular; Molecular Structure; Receptors, Drug; Structure-Activity Relationship | 2000 |
Effects of alpha 2-adrenoceptor antagonists and imidazoline2-receptor ligands on neuronal damage in global ischaemia in the rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Brain Ischemia; Hippocampus; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Neurons; Rats; Rats, Wistar; Receptors, Drug | 1997 |
BU-224 produces spinal antinociception as an agonist at imidazoline I2 receptors.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Electrophysiology; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Nerve Fibers; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord; Synaptic Transmission; Transcutaneous Electric Nerve Stimulation; Yohimbine | 1997 |
Imidazoline (I2) binding sites in chicken brain.
Topics: Agmatine; Amiloride; Animals; Benzofurans; Binding Sites; Binding, Competitive; Brain; Chickens; Clonidine; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Receptors, Drug; Tritium | 1999 |
Imidazoline drugs stabilize lysosomes and inhibit oxidative cytotoxicity in astrocytes.
Topics: Acridine Orange; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Antineoplastic Agents; Apoptosis; Astrocytes; Cathepsin D; Cell Division; Cell Line; Cerebral Cortex; Cytochrome c Group; Fish Venoms; Guanabenz; Guanfacine; HIV Protease Inhibitors; Idazoxan; Imidazoles; Indoles; Isoindoles; L-Lactate Dehydrogenase; Ligands; Lysosomes; Membrane Potentials; Mitochondria; Naphthoquinones; Neuroglia; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Drug | 2002 |
Imidazoline(2) (I(2)) binding site- and alpha(2)-adrenoceptor-mediated modulation of central noradrenergic and HPA axis function in control rats and chronically stressed rats with adjuvant-induced arthritis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; Arthritis, Experimental; Chromatography, High Pressure Liquid; Hypothalamo-Hypophyseal System; Idazoxan; Imidazoles; Male; Microdialysis; Norepinephrine; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Rats; Rats, Mutant Strains; Receptors, Adrenergic, alpha-2; Stress, Psychological | 2002 |
Distribution of [(3)H]BU224, a selective imidazoline I(2) binding site ligand, in rat brain.
Topics: Animals; Autoradiography; Benzofurans; Binding Sites; Binding, Competitive; Brain; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Kinetics; Ligands; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, Drug | 2002 |
Imidazoline2 (I2) receptor- and alpha2-adrenoceptor-mediated modulation of hypothalamic-pituitary-adrenal axis activity in control and acute restraint stressed rats.
Topics: Acute Disease; Adrenergic alpha-Antagonists; Animals; Corticosterone; Dose-Response Relationship, Drug; Hypothalamo-Hypophyseal System; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Restraint, Physical; Stress, Psychological; Time Factors | 2004 |
Estimation of endogenous noradrenaline release in rat brain in vivo using [3H]RX 821002.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Brain; Dextroamphetamine; Idazoxan; Imidazoles; Male; Microdialysis; Monoamine Oxidase Inhibitors; Norepinephrine; Radioligand Assay; Rats; Rats, Wistar; Selegiline; Time Factors; Tissue Distribution; Tritium | 2005 |
Autoradiographic localisation of [3H]2-BFI imidazoline I2 binding sites in mouse brain.
Topics: Animals; Autoradiography; Benzofurans; Binding Sites; Binding, Competitive; Brain; Idazoxan; Imidazoles; Male; Mice; Mice, Inbred C57BL; Midline Thalamic Nuclei; Nucleus Accumbens; Radioligand Assay; Raphe Nuclei; Tritium | 2005 |
Characterisation of imidazoline I2 binding sites in pig brain.
Topics: Animals; Benzofurans; Binding Sites; Binding, Competitive; Brain; Carbolines; Clonidine; Dose-Response Relationship, Drug; Female; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Male; Monoamine Oxidase Inhibitors; Picolinic Acids; Radioligand Assay; Receptors, Drug; Swine; Thiazoles; Tritium | 2005 |
In vivo and in vitro imaging of I₂ imidazoline receptors in the monkey brain.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Brain; Brain Mapping; Carbon Radioisotopes; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Macaca mulatta; Male; Positron-Emission Tomography; Protein Binding; Time Factors | 2011 |
Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.
Topics: Adrenergic alpha-2 Receptor Antagonists; Agmatine; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Yohimbine | 2011 |
Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Blotting, Western; Cell Survival; Dexmedetomidine; Glioma; Glucose; Hypoxia-Inducible Factor 1, alpha Subunit; Idazoxan; Imidazoles; Imidazoline Receptors; Oxygen; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Repressor Proteins; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2012 |
Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: Effects of treatments with I1- and I2-imidazoline drugs.
Topics: Adult; Animals; Antibodies; Benzofurans; Binding Sites; Brain; Cell Membrane; Cytosol; Female; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Mice; Styrenes; Up-Regulation | 2015 |
Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice.
Topics: Animals; Benzofurans; Cerebral Cortex; Cyclin-Dependent Kinase 5; Glutamic Acid; Hippocampus; Idazoxan; Imidazoles; Imidazoline Receptors; Kainic Acid; Ligands; Male; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Styrenes; Time Factors | 2016 |