bts 54 505 has been researched along with sibutramine in 6 studies
| Studies (bts 54 505) | Trials (bts 54 505) | Recent Studies (post-2010) (bts 54 505) | Studies (sibutramine) | Trials (sibutramine) | Recent Studies (post-2010) (sibutramine) |
|---|---|---|---|---|---|
| 6 | 1 | 0 | 967 | 218 | 204 |
| Protein | Taxonomy | bts 54 505 (IC50) | sibutramine (IC50) |
|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 5.665 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 2.39 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 5.665 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 2.085 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.632 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luscombe, GP; Mason, R; Scott, G | 1 |
| Auerbach, SB; Gundlah, C; Heal, DJ; Martin, KF | 1 |
| Buckett, WR; Cheetham, SC; Heal, DJ; Martin, KF; Prow, MR | 1 |
| Heal, DJ; Liu, YL; Stock, MJ | 1 |
| Aspley, S; Bennett, T; Dunn, WR; Gardiner, SM; Heal, DJ; Woolard, J | 1 |
| Chen, HZ; Chen, J; Huang, X; Jiang, XG; Lu, W; Rong, ZX | 1 |
1 trial(s) available for bts 54 505 and sibutramine
| Article | Year |
|---|---|
Pharmacokinetics of sibutramine hydrochloride in Chinese healthy volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclobutanes; Humans; Male; Selective Serotonin Reuptake Inhibitors; Spectrometry, Mass, Electrospray Ionization | 2003 |
5 other study(ies) available for bts 54 505 and sibutramine
| Article | Year |
|---|---|
The effects of BTS 54,505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclobutanes; Evoked Potentials, Visual; Geniculate Bodies; Iontophoresis; Male; N-Methylaspartate; Norepinephrine; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serotonin | 1994 |
In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cyclobutanes; Fenfluramine; Fluoxetine; Male; Microdialysis; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin | 1997 |
A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying agents.
Topics: Amines; Animals; Appetite Depressants; Cyclobutanes; Hypothalamus, Anterior; Male; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Tritium | 1998 |
Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Obesity Agents; Appetite Depressants; Behavior, Animal; Body Temperature; Body Temperature Regulation; Colon; Cyclobutanes; Dopamine Antagonists; Eating; Female; Obesity; Rats; Rats, Wistar; Serotonin Antagonists; Thermogenesis; Time Factors | 2002 |
Acute cardiovascular effects of sibutramine in conscious rats.
Topics: Animals; Antihypertensive Agents; Appetite Depressants; Cardiovascular System; Cyclobutanes; Drug Interactions; Hemodynamics; Norepinephrine; Phentolamine; Propranolol; Rats; Rats, Sprague-Dawley | 2004 |