bruceantin has been researched along with glaucarubinone* in 1 studies
1 other study(ies) available for bruceantin and glaucarubinone
| Article | Year |
|---|---|
Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.
Several quassinoids were identified in a high-throughput screening assay as inhibitors of the transcription factor AP-1. Further biological characterization revealed that while their effect was not specific to AP-1, protein synthesis inhibition and cell growth assays were inconsistent with a mechanism of simple protein synthesis inhibition. Numerous plant extracts from the plant family Simaroubaceae were also identified in the same screen; bioassay-guided fractionation of one extract (Ailanthus triphylla) yielded two known quassinoids, ailanthinone (3) and glaucarubinone (4), which were also identified in the pure compound screening procedure. Topics: Ailanthus; Cytotoxins; Glaucarubin; Humans; Molecular Structure; Protein Synthesis Inhibitors; Quassins; Transcription Factor AP-1 | 2009 |