bromouracil has been researched along with sorivudine in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ashida, N; Baba, M; Ikeda, T; Machida, H; Sakata, S; Shigeta, S | 1 |
| Schuster, AE; Whigan, DB | 1 |
| Ikeda, K; Kawaguchi, K; Nagayama, S; Nakamura, Y; Nishiyama, T; Ogura, K; Ogura, Y; Okuda, H; Watabe, T; Yamaguchi, S | 1 |
| Akimoto, S; Kataoka, K; Kinouchi, T; Matsuda, Y; Nakayama, H; Ohnishi, Y | 1 |
| Diasio, RB; Haworth, S; Lee, PC; McCrary, MM; Olsen, SJ; Raymond, R; Tyring, SK; Yan, J | 1 |
| Arakawa, K; Fukushima, M; Kato, A; Kawaguchi, Y; Nagayama, S; Nishiyama, T; Ogura, K; Okuda, H; Takubo, H; Watabe, T | 1 |
| Kato, A; Ogura, K; Okuda, H; Takubo, H; Watabe, T | 1 |
| Nishiyama, T; Ogura, K; Watabe, T | 1 |
1 review(s) available for bromouracil and sorivudine
| Article | Year |
|---|---|
[Molecular toxicological mechanism of the lethal interactions of the new antiviral drug, sorivudine, with 5-fluorouracil prodrugs and genetic deficiency of dihydropyrimidine dehydrogenase].
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; NADP; Oxidoreductases; Prodrugs; Rats | 2002 |
2 trial(s) available for bromouracil and sorivudine
| Article | Year |
|---|---|
Manual and automated determination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and its metabolite (E)-5-(2-bromovinyl)uracil in urine.
Topics: Antiviral Agents; Arabinofuranosyluracil; Autoanalysis; Bromouracil; Chromatography, High Pressure Liquid; Humans; Robotics | 1995 |
The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analysis of Variance; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Herpes Zoster; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Oxidoreductases; Software; Uracil | 1997 |
5 other study(ies) available for bromouracil and sorivudine
| Article | Year |
|---|---|
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.
Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cytarabine; Drug Combinations; Floxuridine; Fluorouracil; Herpesvirus 3, Human; HIV-1; Humans; Zidovudine | 1992 |
Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Area Under Curve; Bone Marrow Diseases; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Female; Intestine, Small; Liver; Oxidoreductases; Rats; Rats, Wistar; Tegafur; Tissue Distribution | 1997 |
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bacteria, Anaerobic; Bacteroides; Biotransformation; Bromouracil; Cecum; Fluorouracil; Gastric Mucosa; Gastrointestinal Contents; Intestinal Mucosa; Kidney; Liver; Male; Organ Specificity; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Sprague-Dawley | 1997 |
Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.
Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Humans; Oxidoreductases; Recombinant Proteins | 1998 |
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cause of Death; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Fluorouracil; Half-Life; Herpes Zoster; Humans; Liver; Neoplasms; Oxidoreductases; Prodrugs; Rats; Tissue Distribution | 1998 |