Page last updated: 2024-08-17

bromouracil and arabinofuranosyluracil

bromouracil has been researched along with arabinofuranosyluracil in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (63.64)18.2507
2000's3 (27.27)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ashida, N; Baba, M; Ikeda, T; Machida, H; Sakata, S; Shigeta, S1
Schuster, AE; Whigan, DB1
Ikeda, K; Kawaguchi, K; Nagayama, S; Nakamura, Y; Nishiyama, T; Ogura, K; Ogura, Y; Okuda, H; Watabe, T; Yamaguchi, S1
Akimoto, S; Kataoka, K; Kinouchi, T; Matsuda, Y; Nakayama, H; Ohnishi, Y1
Diasio, RB; Haworth, S; Lee, PC; McCrary, MM; Olsen, SJ; Raymond, R; Tyring, SK; Yan, J1
Arakawa, K; Fukushima, M; Kato, A; Kawaguchi, Y; Nagayama, S; Nishiyama, T; Ogura, K; Okuda, H; Takubo, H; Watabe, T1
Kato, A; Ogura, K; Okuda, H; Takubo, H; Watabe, T1
Nishiyama, T; Ogura, K; Watabe, T1
Bergström, M; Fasth, KJ; Långström, B; Lu, L; Samuelsson, L; Sato, K1
Alauddin, MM; Conti, PS; Fissekis, JD; Park, R; Shahinian, A; Tohme, M1
Cai, H; Conti, PS; Li, Z1

Reviews

1 review(s) available for bromouracil and arabinofuranosyluracil

ArticleYear
[Molecular toxicological mechanism of the lethal interactions of the new antiviral drug, sorivudine, with 5-fluorouracil prodrugs and genetic deficiency of dihydropyrimidine dehydrogenase].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2002, Volume: 122, Issue:8

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; NADP; Oxidoreductases; Prodrugs; Rats

2002

Trials

2 trial(s) available for bromouracil and arabinofuranosyluracil

ArticleYear
Manual and automated determination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and its metabolite (E)-5-(2-bromovinyl)uracil in urine.
    Journal of chromatography. B, Biomedical applications, 1995, Feb-17, Volume: 664, Issue:2

    Topics: Antiviral Agents; Arabinofuranosyluracil; Autoanalysis; Bromouracil; Chromatography, High Pressure Liquid; Humans; Robotics

1995
The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster.
    Clinical pharmacology and therapeutics, 1997, Volume: 61, Issue:5

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analysis of Variance; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Herpes Zoster; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Oxidoreductases; Software; Uracil

1997

Other Studies

8 other study(ies) available for bromouracil and arabinofuranosyluracil

ArticleYear
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:1

    Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cytarabine; Drug Combinations; Floxuridine; Fluorouracil; Herpesvirus 3, Human; HIV-1; Humans; Zidovudine

1992
Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:2

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Area Under Curve; Bone Marrow Diseases; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Female; Intestine, Small; Liver; Oxidoreductases; Rats; Rats, Wistar; Tegafur; Tissue Distribution

1997
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil.
    Pharmacogenetics, 1997, Volume: 7, Issue:1

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bacteria, Anaerobic; Bacteroides; Biotransformation; Bromouracil; Cecum; Fluorouracil; Gastric Mucosa; Gastrointestinal Contents; Intestinal Mucosa; Kidney; Liver; Male; Organ Specificity; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Sprague-Dawley

1997
Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.
    Cancer letters, 1998, Jan-09, Volume: 122, Issue:1-2

    Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Humans; Oxidoreductases; Recombinant Proteins

1998
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cause of Death; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Fluorouracil; Half-Life; Herpes Zoster; Humans; Liver; Neoplasms; Oxidoreductases; Prodrugs; Rats; Tissue Distribution

1998
Rat studies comparing 11C-FMAU, 18F-FLT, and 76Br-BFU as proliferation markers.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2002, Volume: 43, Issue:12

    Topics: Animals; Arabinofuranosyluracil; Bromine Radioisotopes; Bromouracil; Cell Division; Dideoxynucleosides; DNA; Fluorine Radioisotopes; Male; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed

2002
Synthesis of 2'-deoxy-2'-[18F]fluoro-5-bromo-1-beta-D-arabinofuranosyluracil ([18F]-FBAU) and 2'-deoxy-2'-[18F]fluoro-5-chloro-1-beta-D-arabinofuranosyl-uracil ([18F]-FCAU), and their biological evaluation as markers for gene expression.
    Nuclear medicine and biology, 2004, Volume: 31, Issue:4

    Topics: Animals; Arabinofuranosyluracil; Biomarkers, Tumor; Bromouracil; Colonic Neoplasms; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Markers; Humans; Isotope Labeling; Metabolic Clearance Rate; Mice; Mice, Nude; Organ Specificity; Radioisotope Dilution Technique; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thymidine Kinase; Tissue Distribution; Tomography, Emission-Computed; Viral Proteins

2004
The improved syntheses of 5-substituted 2'-[18F]fluoro-2'-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep one-pot strategy.
    Nuclear medicine and biology, 2011, Volume: 38, Issue:5

    Topics: Arabinofuranosyluracil; Bromouracil; Fluorouracil; Radiochemistry; Reference Standards

2011
chemdatabank.com