bromouracil has been researched along with 5-(2-bromovinyl)uracil in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Talele, TT | 1 |
| Ashida, N; Baba, M; Ikeda, T; Machida, H; Sakata, S; Shigeta, S | 1 |
| De Clercq, E; Desgranges, C; Herdewijn, P; Jones, AS; McLean, MJ; Sim, IS; Walker, RT | 1 |
| Belloc, I; Bricaud, H; De Clercq, E; Desgranges, C; Drouillet, F; Razaka, G | 1 |
| De Clercq, E; Marquardt, H; Westendorf, J | 1 |
| Balzarini, J; Bricaud, H; De Clercq, E; Desgranges, C; Drouillet, F; Herdewijn, P; Razaka, G | 1 |
| Gerry, N; Robinson, Y; Vose, CW | 1 |
| Schuster, AE; Whigan, DB | 1 |
| Ikeda, K; Kawaguchi, K; Nagayama, S; Nakamura, Y; Nishiyama, T; Ogura, K; Ogura, Y; Okuda, H; Watabe, T; Yamaguchi, S | 1 |
| Akimoto, S; Kataoka, K; Kinouchi, T; Matsuda, Y; Nakayama, H; Ohnishi, Y | 1 |
| Diasio, RB; Haworth, S; Lee, PC; McCrary, MM; Olsen, SJ; Raymond, R; Tyring, SK; Yan, J | 1 |
| Arakawa, K; Fukushima, M; Kato, A; Kawaguchi, Y; Nagayama, S; Nishiyama, T; Ogura, K; Okuda, H; Takubo, H; Watabe, T | 1 |
| Kato, A; Ogura, K; Okuda, H; Takubo, H; Watabe, T | 1 |
| Bellemann, ME; Brix, G; Haberkorn, U | 1 |
| Ito, K; Kanamitsu, SI; Muro, K; Ogura, K; Okuda, H; Sugiyama, Y; Watabe, T | 1 |
| Kato, A; Nishiyama, T; Ogura, K; Okuda, H; Suda, K; Watabe, T | 1 |
| Balzarini, J; Carangio, A; De Clercq, E; Esnouf, R; Liekens, S; McGuigan, C; Sienaert, R; Van Kuilenburg, A | 1 |
| Nishiyama, T; Ogura, K; Watabe, T | 1 |
| Hirao, Y; Inada, M; Itose, M; Koga, T; Kunizaki, J; Sato, H; Shimizu, T | 1 |
1 review(s) available for bromouracil and 5-(2-bromovinyl)uracil
| Article | Year |
|---|---|
[Molecular toxicological mechanism of the lethal interactions of the new antiviral drug, sorivudine, with 5-fluorouracil prodrugs and genetic deficiency of dihydropyrimidine dehydrogenase].
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; NADP; Oxidoreductases; Prodrugs; Rats | 2002 |
3 trial(s) available for bromouracil and 5-(2-bromovinyl)uracil
| Article | Year |
|---|---|
Manual and automated determination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and its metabolite (E)-5-(2-bromovinyl)uracil in urine.
Topics: Antiviral Agents; Arabinofuranosyluracil; Autoanalysis; Bromouracil; Chromatography, High Pressure Liquid; Humans; Robotics | 1995 |
The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analysis of Variance; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Herpes Zoster; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Oxidoreductases; Software; Uracil | 1997 |
Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: inhibition of 5-fluorouracil metabolism by (E)-5-(2-Bromovinyl)uracil.
Topics: Adult; Aged; Animals; Antimetabolites; Antiviral Agents; Area Under Curve; Blood Proteins; Blotting, Western; Bromouracil; Cytosol; Depression, Chemical; Drug Interactions; Female; Fluorouracil; Half-Life; Humans; Luminescent Measurements; Male; Middle Aged; Protein Binding; Rats | 2000 |
15 other study(ies) available for bromouracil and 5-(2-bromovinyl)uracil
| Article | Year |
|---|---|
Acetylene Group, Friend or Foe in Medicinal Chemistry.
Topics: Acetylene; Alkynes; Animals; Anti-Inflammatory Agents; Chemistry, Pharmaceutical; Click Chemistry; Half-Life; HIV Reverse Transcriptase; HIV-1; Humans; Macrophages; Mice; Protein Kinase Inhibitors; Rats; Reverse Transcriptase Inhibitors | 2020 |
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.
Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cytarabine; Drug Combinations; Floxuridine; Fluorouracil; Herpesvirus 3, Human; HIV-1; Humans; Zidovudine | 1992 |
Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Bromouracil; Deoxyuridine; Herpes Simplex; Mice; Mice, Inbred BALB C; Rabbits; Simplexvirus; Thymine; Uridine; Virus Replication | 1986 |
Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5-ethyl-2'-deoxyuridine and 5-(2-chloroethyl)-2'-deoxyuridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Bromouracil; Deoxyuridine; Half-Life; Humans; Male; Rabbits; Rats; Rats, Inbred Strains; Simplexvirus; Uracil | 1986 |
Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Bromouracil; Cells, Cultured; Cricetinae; Cricetulus; DNA Repair; Liver; Male; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1985 |
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
Topics: Animals; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Fluorouracil; Leukemia P388; Leukemia, Experimental; Liver; Metabolic Clearance Rate; Mice; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil | 1986 |
Simultaneous high-performance liquid chromatographic assay for 5-(2-bromo-E-ethenyl)-2'-deoxyuridine and its metabolite, 5-(2-bromo-E-ethenyl)uracil, in plasma.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Bromouracil; Chromatography, High Pressure Liquid; Dogs; Humans; Rats; Reference Standards; Species Specificity | 1985 |
Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Area Under Curve; Bone Marrow Diseases; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Female; Intestine, Small; Liver; Oxidoreductases; Rats; Rats, Wistar; Tegafur; Tissue Distribution | 1997 |
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bacteria, Anaerobic; Bacteroides; Biotransformation; Bromouracil; Cecum; Fluorouracil; Gastric Mucosa; Gastrointestinal Contents; Intestinal Mucosa; Kidney; Liver; Male; Organ Specificity; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Sprague-Dawley | 1997 |
Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.
Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Humans; Oxidoreductases; Recombinant Proteins | 1998 |
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cause of Death; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Fluorouracil; Half-Life; Herpes Zoster; Humans; Liver; Neoplasms; Oxidoreductases; Prodrugs; Rats; Tissue Distribution | 1998 |
Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5-fluorouracil by 5-bromovinyluracil: assessment with metabolic (19)F MR imaging.
Topics: Animals; Antimetabolites, Antineoplastic; beta-Alanine; Biotransformation; Bromouracil; Cell Division; Dose-Response Relationship, Drug; Fluorouracil; Immunologic Factors; Liver; Liver Neoplasms, Experimental; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Neoplasm Transplantation; Rats; Rats, Inbred ACI; Tissue Distribution; Tumor Cells, Cultured | 1999 |
Mechanism-based inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil in the presence of NADPH.
Topics: Amino Acid Sequence; Antiviral Agents; Bromouracil; Carbon Radioisotopes; Dihydrouracil Dehydrogenase (NADP); Humans; Molecular Sequence Data; NADP; Oxidoreductases; Peptide Fragments; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2000 |
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.
Topics: Animals; Antiviral Agents; Binding Sites; Bromodeoxyuridine; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Escherichia coli; Fluorouracil; Herpesvirus 3, Human; Heterocyclic Compounds, 2-Ring; Humans; Mice; Models, Molecular; Nucleosides; Oxidoreductases; Substrate Specificity; Thymidine Phosphorylase | 2002 |
Relationships among plasma [2-(13)C]uracil concentrations, breath (13)CO(2) expiration, and dihydropyrimidine dehydrogenase (DPD) activity in the liver in normal and dpd-deficient dogs.
Topics: Administration, Oral; Animals; Breath Tests; Bromouracil; Carbon Dioxide; Carbon Isotopes; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Dogs; Injections, Intravenous; Liver; Male; Uracil | 2005 |