bromodeoxyuridine has been researched along with brivudine in 366 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 211 (57.65) | 18.7374 |
| 1990's | 57 (15.57) | 18.2507 |
| 2000's | 65 (17.76) | 29.6817 |
| 2010's | 32 (8.74) | 24.3611 |
| 2020's | 1 (0.27) | 2.80 |
| Authors | Studies |
|---|---|
| Duncan, IB; Hall, MJ; Heimer, EP; Lambert, RW; Martin, JA; Thomas, GJ | 1 |
| Cech, D; Pein, CD; Reefschläger, J | 1 |
| Alessi, EM; Bardos, TJ; Cheng, YC; Efange, SM; Shih, HC | 1 |
| Balzarini, J; Bentrude, WG; Béres, J; De Clercq, E; Otvös, L; Sági, G | 1 |
| Cordeiro, MN; Fernández, F; García-Mera, X; Helguera, AM; Rodríguez-Borges, JE | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Barr, PJ; De Clercq, E; De Somer, P; Descamps, J; Jones, AS; Walker, RT | 2 |
| De Clercq, E; Descamps, J; Maudgal, PC; Missotten, L | 2 |
| Gati, WP; Knaus, EE; Kumar, P; Singh, S; Tandon, M; Tempest, ML; Wiebe, LI; Xu, L | 1 |
| Machida, H; Suzutani, T | 1 |
| Balwierz, PS; Garriott, ML; Oshiro, Y; Piper, CE; Soelter, SG | 1 |
| Dénes, G; Gács-Baitz, E; Szabolcs, A; Szinai, I; Ujszászy, K; Veres, Z | 1 |
| De Clercq, E; Maudgal, PC | 5 |
| De Clercq, E; Rapp, F; Shiraki, K; Vonka, V | 1 |
| Claes, P; De Clercq, E; Herdewijn, P; Pannecouque, C; Snoeck, R; Wigerinck, P | 1 |
| Dobson, AT; Docherty, JJ; Jennings, BA; Trimble, JJ | 1 |
| Bull, CO; Landry, ML; Milstone, LM; Reuveni, H; Schwartz, PM | 1 |
| Benedict-Smith, A; Brady, K; Collum, LM; Hillery, M; Power, WJ | 2 |
| Maudgal, PC; Rietveld, E; Suir, EP; Zaal, MJ | 1 |
| Balasubramaniam, NK; Gentry, GA; Veerisetty, V | 1 |
| De Clercq, E; Iigo, M; Miwa, M | 1 |
| De Clercq, E; Hoshi, A; Iigo, M; Nakajima, Y; Nishikata, K | 1 |
| Aduma, PJ; De Clercq, E; Gupta, SV | 1 |
| De Clercq, E; Nakane, H; Ono, K | 1 |
| Burns, WH; Sandford, GR | 1 |
| Colacino, JM; Ganley, JP; Kaiwar, R; Langford, MP; Mahjoub, SB | 1 |
| Armstrong, B; Hannigan, BM; McKenna, PG; Modjtahedi, H; O'Neill, KL | 1 |
| Bryson, YJ | 1 |
| Prange, HW | 1 |
| Rapp, F; Scheck, AC; Wigdahl, B | 2 |
| Davidson, MG; De Clercq, E; Guy, JS; Nasisse, MP; Sussman, W | 1 |
| De Clercq, E; Hoshi, A; Iigo, M; Nakajima, Y; Nishikata, K; Odagiri, H; Okudaira, N | 1 |
| Coen, DM; Irmiere, AF; Jacobson, JG; Kerns, KM | 1 |
| Shigeta, S | 1 |
| Bernaerts, R; De Clercq, E; Desgranges, C | 1 |
| Balzarini, J; De Clercq, E | 1 |
| Bijlenga, G; De Clercq, E; Joubert, L | 1 |
| Ameye, C; de Clercq, E; Sundmacher, R | 1 |
| de Clercq, E; Maudgal, PC; Meurs, PJ; van Bijsterveld, OP | 1 |
| Corrias, MV; Flore, O; La Colla, P; Lecca, U; Marcello, C; Marongiu, ME; Pani, A | 1 |
| Benad, A; Richter, E | 1 |
| Jackson, LS; Stafford, JE | 1 |
| Ayusawa, D; Balzarini, J; De Clercq, E; Seno, T; Shimizu, K; Verbruggen, A | 1 |
| Bärwolff, D; Langen, P; Reefschläger, J; Thiel, KD; Töpke, H; Wutzler, P | 1 |
| Balzarini, J; Bubley, GJ; Crumpacker, CS; de Clercq, E; Schnipper, LE | 1 |
| Galegov, GA; Malinovskaia, VV; Manakhova, LS; Mironova, LL; Temicheva, EV | 1 |
| De Clercq, E; Robin, JB; Trousdale, MD; Willey, DE | 1 |
| Helbig, B; Herrmann, G; Klöcking, R; Sauerbrei, A; Wicht, N; Wiedemann, U; Wutzler, P | 1 |
| Hernáez Lobo, R; Pérez Breña, P; Rojas, JM; Salmerón, F; Tabarés, E | 1 |
| De Clercq, E; Griengl, H; Hayden, W; Penn, G; Rosenwirth, B | 1 |
| Datema, R; De Clercq, E; Hirschberg, C; Milla, M; Olofsson, S | 1 |
| Lin, JC; Machida, H | 1 |
| Bärwolff, D; Reefschläger, J; Wutke, K; Wutzler, P | 1 |
| Rajcáni, J; Reefschläger, J | 1 |
| Bird, RM; Broadhurst, AV; Duncan, IB; Hall, MJ; Lambert, RW; Wong-Kai-In, P | 1 |
| De Clercq, E; Huyghe, P; Maudgal, PC | 2 |
| Boogaerts, M; De Clerck, D; De Clercq, E; Vinckier, F | 1 |
| De Clercq, E; Jelínek, R | 1 |
| Coen, DM; Fleming, HE; Leslie, LK; Retondo, MJ | 1 |
| Balzarini, J; Bernaerts, R; De Clercq, E; Herdewijn, P; Verbruggen, A | 1 |
| Fong, CK; Hsiung, GD; Mayo, DR; Winship, T; Zheng, ZM | 1 |
| Egbertson, S; Hilliard, J; Landry, M; Mayo, D; Mirkovic, R | 1 |
| Arens, MQ; Rivetna, KA; Swierkosz, EM | 1 |
| Croson, SE; Docherty, JJ; Henchal, LS; Mundon, FK; O'Neill, SP; Zimmerman, DH | 1 |
| Chen, HS; De Clercq, E; Dong, WP; Liu, SM; Xu, ZG; Zhang, ZH; Zhang, ZX | 1 |
| Balzarini, J; De Clercq, E; Herdewijn, P; Vanderhaeghe, H | 1 |
| Ayusawa, D; Balzarini, J; de Clercq, E; Seno, T | 1 |
| Shigeta, S; Yokota, T | 1 |
| Field, HJ | 1 |
| De Clercq, E; Freeman, DJ; Sacks, SL; Spruance, SL | 1 |
| Docherty, JJ; Faulkner, SC; Mundon, FK; Naugle, FP; Roman, SR; Trimble, JJ; Zimmerman, DH | 1 |
| Gentry, GA; Veerisetty, V | 3 |
| Balkovic, ES; Hsiung, GD | 1 |
| Datema, R; Lundström, M; Olofsson, S | 1 |
| Ayusawa, D; Balzarini, J; De Clercq, E; Seno, T; Verbruggen, A | 1 |
| Burns, WH; Chen, MS; Ghazzouli, I; McLaren, C; Saral, R | 1 |
| Choi, EI; De Clercq, E; Lin, JC; Pagano, JS; Smith, MC; Verbruggen, A | 1 |
| De Clercq, E; Shigeta, S; Yokota, T | 1 |
| Ayisi, N; De Clercq, E; Sacks, S; Wall, R | 1 |
| Ayusawa, D; Balzarini, J; De Clercq, E; Seno, T; Shimizu, K | 1 |
| De Clercq, E; Desgranges, C; Herdewijn, P; Jones, AS; McLean, MJ; Sim, IS; Walker, RT | 1 |
| Graham, D; Inglis, MM; Larder, BA | 1 |
| Eggers, HJ | 2 |
| De Clercq, E; Rapp, F; Scheck, AC; Wigdahl, B | 1 |
| Herrmann, G; Reefschläger, J; Thiel, KD; Wutzler, P | 1 |
| Belloc, I; Bricaud, H; De Clercq, E; Desgranges, C; Drouillet, F; Razaka, G | 1 |
| Sacks, SL | 1 |
| Maragos, C; May, JT; Shaw, R | 1 |
| De Clercq, E | 10 |
| De Clercq, E; Ichimura, H; Kit, S | 1 |
| Baringer, JR; Dix, RD; Panitch, HS; Pulliam, L | 1 |
| De Clercq, E; Konno, K; Shigeta, S; Verbruggen, A; Yokota, T | 1 |
| Machida, H; Saneyoshi, M; Suzuki, S | 1 |
| Baba, M; De Clercq, E; Shigeta, S | 2 |
| De Clercq, E; Griengl, H; Rosenwirth, B; Schwarz, W; Streicher, W; Wanek, E | 1 |
| Freeman, DJ; Spruance, SL | 1 |
| De Clercq, E; Hoshi, A; Iigo, M; Nishimura, S; Yamaizumi, Z | 1 |
| De Clercq, E; Hoshi, A; Iigo, M; Nakajima, Y | 1 |
| Dunkel, EC; Geary, PA; Imperia, PS; Lass, JH; Lazarus, HM; Pavan-Langston, D | 1 |
| de Bruijn, EA; Keizer, HJ; Lingeman, H; Reeuwijk, HJ; Tjaden, UR; van der Greef, J | 1 |
| Gräf, M; Herrmann, G; Reefschläger, J; Töpke, H; Wutzler, P | 1 |
| Chengelis, CP; Dickie, BC; Port, CD | 1 |
| Araki, E; De Clercq, E; Hoshi, A; Iigo, M; Nakajima, Y | 1 |
| Balzarini, J; De Clercq, E; Keizer, HJ; Landuyt, W; Pauwels, R; van der Schueren, E | 1 |
| De Clercq, E; Kimura, T; Nishizawa, T; Yoshimizu, M | 1 |
| De Clercq, E; De Fazio, G; Vicente, M | 1 |
| Ayisi, NK; De Clercq, E; Machida, H; Sacks, SL; Wall, RA; Wanklin, RJ | 1 |
| Boogaerts, MA; De Clercq, E; Tricot, G; Verwilghen, RL | 1 |
| Czugler, M; Kálmán, A; Kovács, T; Párkányi, L; Walker, RT | 1 |
| De Clercq, E; Geursen, R; Hilfenhaus, J; Köhler, R; Seiler, F | 1 |
| Ayisi, NK; De Clercq, E; Sacks, SL; Wall, RA | 1 |
| Bernaerts, R; Breemersch, M; De Clercq, E; Dieltiens, M; Maudgal, PC; Van Eeckhoutte, L | 1 |
| Boyd, MR; Cole, M; Harnden, MR; Hodge, RA; Luk, K; Rush, MA; Sutton, D | 1 |
| Ben-Efraim, S; de Clercq, E; Shoval, S | 1 |
| De Clercq, E; Marquardt, H; Westendorf, J | 1 |
| Benoit, Y; De Clercq, E; Delbeke, MJ; Laureys, G | 1 |
| Fox, JJ; Perlman, ME; Schinazi, RF; Watanabe, KA | 1 |
| Gerry, N; Robinson, Y; Vose, CW | 1 |
| Bachmayer, H; Bodenteich, M; Ghazzouli, I; Griengl, H; Hayden, W; Rosenwirth, B; Streicher, W; Stütz, P; Wanek, E | 1 |
| Amankwa, L; Chatten, LG | 1 |
| Rapp, F | 1 |
| Overall, JC; Salmon, VC; Stanberry, LR | 1 |
| Ayisi, NK; De Clercq, E; Hughes, H; Sacks, SL; Wall, RA | 1 |
| Lee, JJ; Lin, TS; Mancini, WR; Otto, MJ; Prusoff, WH; Siegel, SA | 1 |
| Harmenberg, J | 1 |
| De Clercq, E; Walker, RT | 1 |
| Francke, B; Hsiung, GD; Mayo, DR; Wohlrab, F | 1 |
| Bärwolff, D; Herrmann, G; Langen, P; Reefschläger, J | 1 |
| Nicholson, KG | 1 |
| Chekunova, EV; Gorbovitskaya, GE; Kulak, TI; Marennikova, SS; Matsevich, GR; Mikhailopulo, IA; Nikulina, VG | 1 |
| De Clercq, E; Descamps, J; Huygen, K; Zhen-Xi, Z | 1 |
| Galasso, GJ | 1 |
| De Clercq, E; Rapp, F; Scheck, AC; Wigdahl, BL | 1 |
| Hirsch, MS; Schooley, RT | 1 |
| Hirsch, MS; Wong, KK | 1 |
| White, DO | 1 |
| Friedman-Kien, AE; Klein, RJ | 1 |
| Darby, G; Field, H; McMillan, A | 1 |
| Field, HJ; Wildy, P | 1 |
| De Clercq, E; Jones, AS; Rahim, SG; Walker, RT | 1 |
| Allaudeen, HS; Bertino, JR; De Clercq, E; Kozarich, JW | 1 |
| Cheng, YC; De Clercq, E; Dutschman, G; Jones, AS; Rahim, SG; Verhelst, G; Walker, RT | 1 |
| Larsson, A; Oberg, B | 1 |
| Bergstrom, DE; de Clercq, E; Descamps, J; Verhelst, G | 1 |
| De Clercq, E; Field, HJ | 1 |
| Isom, HC; Rapp, F; Wigdahl, BL | 1 |
| Allaudeen, HS; Chen, MS; De Clercq, E; Lee, JJ; Prusoff, WH | 1 |
| Oxford, JS | 1 |
| Crumpacker, CS; Hershey, BJ; Kowalsky, PN; Levin, MJ; Marlowe, SI; Schnipper, LE | 1 |
| Honess, RW; O'Hare, P; Young, D | 1 |
| De Clercq, E; Isom, HC; Rapp, F; Wigdahl, BL | 1 |
| Mayo, DR | 1 |
| De Clercq, E; Descamps, J; Ogata, M; Shigeta, S | 1 |
| Fyfe, JA | 2 |
| Declercq, E; Park, NH; Pavan-Langston, D | 1 |
| Nahmias, AJ; Schinazi, RF | 1 |
| Biron, KK; Elion, GB | 1 |
| Bärwolff, D; Brwolff, D; Langen, P; Reefschläger, J; Rosenthal, HA | 1 |
| Crumpacker, CS; Kowalsky, PN; Schnipper, LE; Sherman, DM | 1 |
| Allaudeen, HS; De Clercq, E; Descamps, J; Sehgal, RK | 1 |
| Field, HJ; Neden, J | 1 |
| Bärwolff, D; Langen, P; Reefschläger, J; Rosenthal, HA; Sprössig, M; Thiel, KD; Wutzler, P | 1 |
| De Clercq, E; Mancini, WR; Prusoff, WH | 1 |
| Cheng, YC; Dutschman, GE; Grill, SP; Schinazi, RF; Tan, RS | 1 |
| Gronowitz, JS; Harmenberg, J; Källander, CF | 1 |
| Hsiung, GD; Mayo, DR; Zheng, ZM | 1 |
| Goudsmit, J; van der Noordaa, J | 1 |
| Cheng, YC; Lin, JC; Pagano, JS; Smith, MC | 1 |
| Acres, SD; Babiuk, LA; De Clercq, E; Misra, V; Stockdale, PH | 1 |
| Fyfe, JA; Keller, PM; McKee, SA | 1 |
| Bubley, G; Crumpacker, C; De Clercq, E; Schnipper, L | 1 |
| Rapp, F; Smith, CA; Wigdahl, B | 1 |
| Boisjoly, HM; De Clercq, E; Park, NH; Pavan-Langston, D | 2 |
| Lemchuk-Favel, L; Sacks, SL; Teh, CZ | 1 |
| Centifanto-Fitzgerald, YM; De Clercq, E; Kaufman, HE; Kissling, GE; Varnell, ED | 1 |
| Allaudeen, HS; Chen, HC; De Clercq, E; Liu, YX; Zhang, ZX | 1 |
| Dellaria, MF; Docherty, JJ; Knerr, RA; Lohse, MA; Mason, CW; McDermott, HM; Mundon, FK; Naugle, FP; Zimmerman, DH | 1 |
| Buckmaster, EA; Coombs, RR; Cranage, MP; McLean, CS; Minson, A | 1 |
| Anderson, JR; Efstathiou, S; Field, HJ | 1 |
| Baba, M; De Clercq, E; Ito, M; Shigeta, S | 1 |
| De Clercq, E; Otto, MJ; Prusoff, WH; Siegel, SA | 1 |
| Cheng, YC; De Clercq, E; Dutschman, GE; Zou, FC | 1 |
| De Clercq, E; Park, NH; Pavan-Langston, D | 2 |
| De Clercq, E; Maudgal, PC; Missotten, L | 1 |
| De Clercq, E; Kelly, DC; Lescott, T; Wang, X | 1 |
| Maudgal, PC; Missotten, L; Van Damme, B | 1 |
| Johansson, NG; Oberg, B | 1 |
| Walker, RT | 1 |
| Knaus, EE; Samuel, J; Tyrrell, DL; Wiebe, LI | 1 |
| De Clercq, E; Wildiers, J | 1 |
| Hirsch, MS | 1 |
| Allaudeen, HS; De Clercq, E; Hantz, O; Ooka, T; Trepo, C | 1 |
| Sim, IS | 1 |
| Park, NH | 1 |
| Babiuk, LA; Misra, V; Nelson, RC | 1 |
| Kálmán, A; Kovács, T; Otvös, L; Párkányi, L; Szabolcs, A | 1 |
| Marmer, DJ; Steele, RW | 1 |
| Herrmann, G; Liermann, B | 1 |
| Balzarini, J; Bricaud, H; De Clercq, E; Desgranges, C; Rabaud, M; Razaka, G | 1 |
| Arvin, AM; Cohen, PS; De Clercq, E; Koropchak, CM; Smith, SD; Wittek, AE | 1 |
| Bricaud, H; De Clercq, E; Desgranges, C; Drouillet, F; Herdewijn, P; Razaka, G | 1 |
| Czuppon, A; Kajtár, M; Otvös, L; Sági, J; Szabolcs, A; Szemzö, A | 1 |
| Cassiman, JJ; De Clercq, E; Jones, AS; Van den Berghe, H; Walker, RT | 1 |
| De Clercq, E; Descamps, J; Maudgal, PC; Missotten, L; Wijnhoven, J | 1 |
| De Clercq, E; Maudgal, PC; Missotten, L; Uyttebroeck, W | 1 |
| De Clercq, E; Descamps, J; Dralands, L; Lamberts, L; Maudgal, PC; Missotten, L | 1 |
| Allaudeen, HS; De Clercq, E; Descamps, J; Jones, AS; Kozarich, JW; Walker, RT | 1 |
| De Clercq, E; De Meuter, E; Descamps, J; Maudgal, PC; Missotten, L | 1 |
| De Clercq, E; De Kimpe, N; Descamps, J; Geysen, A; Maudgal, PC; Missotten, L | 1 |
| de Clercq, E; Sim, IS; Zhang, ZX | 1 |
| Billiau, A; De Clercq, E; De Ley, M; Descamps, J; Heremans, H; Verhelst, G | 1 |
| Albert, DM; De Clercq, E; Hettinger, ME; Lin, TS; Park, NH; Pavan-Langston, D | 1 |
| De Clercq, E; Jones, AS; Rahim, SG; Serafinowski, P; Walker, RT | 1 |
| Busson, R; De Clercq, E; De Somer, P; Descamps, J; Jones, AS; Maudgal, PC; Missotten, L; Vanderhaeghe, H; Verhelst, G; Walker, RT | 1 |
| de Clercq, E; de Jonge, G; de Somer, P; Degreef, H; Descamps, J; Drochmans, A; Wildiers, J | 1 |
| De Clercq, E; Färber, I; Wutke, K; Wutzler, P | 1 |
| Brown, SL; Freytag, SO; Kim, JH; Kim, OB; Kim, SH; Kolozsvary, A | 1 |
| Arcamone, F; Ciarrocchi, G; Focher, F; Garbesi, A; Iafrate, E; Maga, G; Manzini, S; Spadari, S; Tondelli, L; Verri, A | 1 |
| Pancheva, SN | 1 |
| Brown, SL; Freytag, SO; Kim, JH; Kim, SH | 1 |
| Creuven, I; Dory, M; Durant, F; Evrard, C; Evrard, G; Herdewijn, P; Olivier, A; van Aerschot, A; Wigerinck, P | 1 |
| Docherty, JJ; Wilber, BA | 1 |
| Balzarini, J; Bohman, C; de Clercq, E; Walker, RT | 1 |
| De Bruijn, EA; De Clercq, E; Keizer, HJ; Tjaden, UR | 1 |
| Clairmont, C; Hellstrand, K; Hirschberg, C; Olofsson, S; Shugar, D; Sjöblom, I | 1 |
| Balzarini, J; Bohman, C; De Clercq, E | 1 |
| Das, GK; Khokhar, S; Panda, A; Rao, V | 1 |
| Smith, G | 1 |
| Bishop, JO; Ellison, AR | 1 |
| De Clercq, E; Hashimoto, K; Igarashi, A; Kodama, E; Mori, S; Shigeta, S; Suzuki, T | 1 |
| Freytag, SO; Kim, JH; Kim, SH; Rogulski, KR | 1 |
| Fahrig, R | 1 |
| Calberg-Bacq, CM; Grignet-Debrus, C | 1 |
| Collin, B; Neubert, R; Wartewig, S | 1 |
| Heider, H; Schroeder, C | 1 |
| Färber, I; Ulbricht, A; Wutzler, P | 1 |
| Clercq, E; Dralands, L; Dullaert, H; Leys, A; Maudgal, PC | 1 |
| Hengst, U; Prager, J; Sauerbrei, A; Wutzler, P; Zintl, F | 1 |
| Focher, F; Priori, G; Spadari, S; Tondelli, L; Verri, A | 1 |
| Akberova, SI; Galegov, GA; Leont'eva, NA; Stroeva, OG | 1 |
| De Clercq, E; Neyts, J | 1 |
| Wutzler, P | 1 |
| Afouna, MI; De Clercq, E; El-Shattawy, HH; Ghanem, AH; Higuchi, WI; Kern, ER; Mehta, SC | 1 |
| Smith, GA; Whalley, JM | 1 |
| Goerdt, S; Husak, R; Orfanos, CE; Stöffler-Meilicke, M; Tebbe, B; Wölfer, LU; Zeichardt, H | 1 |
| Blaschke, G; Boos, J; Hempel, G; Olgemöller, J | 1 |
| Reeuwijk, HJ; Tjaden, UR; van der Greef, J | 1 |
| Blaese, RM; Candotti, F; Wildner, O | 1 |
| Balzarini, J; Baudson, N; Calberg-Bacq, CM; Cool, V; De Leval, L; Debrus, S; Degrève, B; Grignet-Debrus, C; Velu, T | 1 |
| Andrei, G; De Clercq, E; Myhren, F; Neyts, J; Sandvold, ML; Snoeck, R | 1 |
| Agbaria, R; Balzarini, J; Blaese, RM; Candotti, F; Johns, DG; Mullen, CA; Touraine, R | 1 |
| Berebbi, M; Kudelova, M; Macakova, K; Matis, J; Raslova, H; Rezuchova, I | 1 |
| Weber, O | 1 |
| Johansson, M; Karlsson, A; Zheng, X | 3 |
| Balzarini, J; De Clercq, E; Degrève, B | 1 |
| Beryt, M; Boyer, C; Groziak, MP; Johnston, P; Lackey, DB; Park, JW; Pegram, M; Sayre, P; Sergeeva, M; Shepard, HM; Slamon, D; Stroud, RM | 1 |
| Hewlett, G; Kreuter, J; Pawellek, A; Rübsamen-Waigmann, H; Weber, O | 1 |
| Fahrig, R; Schaefer, A; Steinkamp-Zucht, A | 1 |
| Hamel, W; Israel, MA; Mehdorn, HM; Westphal, M; Zirkel, D | 1 |
| Lomp, A; Meerbach, A; Meier, C; Wutzler, P | 1 |
| Altaner, C; Hlavatý, J; Hlubinová, K | 1 |
| De Clercq, E; Naesens, L | 1 |
| Andrei, G; Balzarini, J; De Clercq, E; Harris, SA; McGuigan, C; Snoeck, R | 1 |
| Balzarini, J; Carangio, A; De Clercq, E; Esnouf, R; Liekens, S; McGuigan, C; Sienaert, R; Van Kuilenburg, A | 1 |
| Christmann, M; Friedrichs, C; Kaina, B; Thust, R; Tomicic, MT; Wutzler, P | 1 |
| Doerr, HW; Friese, K; Gross, G; Guthoff, R; Malin, JP; Pau, HW; Schöfer, H; Timm, A; Wassilew, S; Wutzler, P | 1 |
| Folkers, G; Novellino, E; Scapozza, L; Spadola, L | 1 |
| Lilie, HM; Wassilew, S | 1 |
| Wassilew, SW; Wutzler, P | 2 |
| Rabasseda, X | 1 |
| Doerr, HW; Gross, G | 1 |
| Ernst, H; Fahrig, R; Fiedler, B; Heinrich, JC; Krupitza, G; Leisser, C; Nickel, B; Praha, C; Scherthan, H; Sonntag, D; Wilfert, F | 1 |
| Bornfeld, N; Fiedler, M; Roggendorf, M; Schilling, H; Vij, O | 1 |
| Johansson, M; Karlsson, A; Lundberg, M; Zheng, X | 1 |
| De Clercq, E; Fernández, S; Ferrero, M; Gotor, V; Lavandera, I | 1 |
| Andrei, G; De Clercq, E; Snoeck, R | 1 |
| Ensser, A; Hoggarth, JH; Jones, E; Meredith, DM | 1 |
| Chapman, TM; Figgitt, DP; Keam, SJ | 1 |
| Wassilew, S | 1 |
| Andrei, G; Balzarini, J; De Clercq, E; McGuigan, C; Sienaert, R; Snoeck, R | 1 |
| Andrei, G; Balzarini, J; De Clercq, E; Fiten, P; Opdenakker, G; Snoeck, R | 1 |
| Balzarini, J; Breuer, M; De Loof, A; Huybrechts, R | 1 |
| Dediulescu, DF; Dediulescu, L | 1 |
| Congiatu, C; Davies, G; Jiang, WG; Mason, MD; McGuigan, C | 1 |
| Gross, G; Hercogova, J; Johnson, RW; Volpi, A | 1 |
| Abraham, S; Chavaz, P; Jones, A; Kerl-Bullani, K; Piguet, V; Saurat, JH; Toutous-Trellu, L | 1 |
| Meerbach, A; Meier, C; Sauerbrei, A; Wutzler, P | 1 |
| Balzarini, J; Bianchi, V; Franzolin, E; Hernández, AI; Pérez-Pérez, MJ; Rampazzo, C | 1 |
| Abdel-Haq, N; Al-Tatari, H; Asmar, B; Chearskul, P | 1 |
| Wassilew, SW | 1 |
| Boeck, S; Fahrig, R; Hänel, M; Heinemann, V; Heinrich, JC; Krupitza, G; Liebert, A; Praha, C; Quietzsch, D; Schmid, RM; Sonntag, D | 1 |
| Backonja, M; Betts, RF; Breuer, J; Dworkin, RH; Gershon, AA; Gnann, JW; Haanpaa, ML; Johnson, RW; Levin, MJ; McKendrick, MW; Nurmikko, TJ; Oaklander, AL; Oxman, MN; Pavan-Langston, D; Petersen, KL; Rowbotham, MC; Schmader, KE; Stacey, BR; Tyring, SK; van Wijck, AJ; Wallace, MS; Wassilew, SW; Whitley, RJ | 1 |
| Brancale, A; Congiatu, C; McGuigan, C | 1 |
| Balzarini, J; Jasamai, M; Simons, C | 1 |
| Eklund, H; Mikkelsen, NE; Munch-Petersen, B | 1 |
| Cappellacci, L; Franchetti, P; Grifantini, M; Petrelli, R; Vita, P | 1 |
| Grüne, S; Pichler, J; Seidel, BM | 1 |
| Eriksson, S; Wang, L | 1 |
| Correia, O; Pereira, MA; Pereira, T; Santos, A | 1 |
| Kumar, V; Malhotra, SV | 1 |
| Agrofoglio, LA; Balzarini, J; Caillat, C; Deville-Bonne, D; Meyer, P; Pochet, S; Topalis, D | 1 |
| Hofer, S; Krähenbühl, S; Ludwig, C; Rätz Bravo, AE | 1 |
| Dorio, AS; Graziani, G; Muzi, A; Shah, GM; Terrinoni, A; Vernole, P; Volpi, A | 1 |
| Bihl, F; Hadengue, A; Mottu, A; Rubbia-Brandt, L; Spahr, L | 1 |
| Baena-Cañada, JM; García-Olmedo, O; Jiménez-Bárcenas, R; Martínez, MJ; Muriel-Cueto, P | 1 |
| Frank, H; Heemann, U; Hoffmann, D; Küchle, C; Lahmer, T | 1 |
| Deinhardt, S; Sauerbrei, A; Wutzler, P; Zell, R | 1 |
| Balzarini, J; Bjerke, M; Johansson, M; Karlsson, A; Lesko, N; Solaroli, N | 1 |
| Borde, JP; Offensperger, WB | 1 |
| Bleymehl, K; Cinatl, J; Schmidt-Chanasit, J | 1 |
| Iizuka, I; Kurane, I; Lixin, W; Mizuguchi, M; Morikawa, S; Nishimura, H; Ogata, M; Saijo, M; Shiota, T; Takayama-Ito, M; Taniguchi, S; Tsuji, M | 1 |
| Fahrig, R; Fahrig, T; Heinrich, JC; Schroeder, M; Tuukkanen, A | 1 |
| Bohn, K; Hamprecht, K; Heim, A; Hoffmann, D; Hofmann, J; Jahn, G; Sauerbrei, A; Schnitzler, P; Weissbrich, B; Wutzler, P; Zell, R | 1 |
| de Kock, J; McDonald, EM; Ram, FS | 1 |
| Balzarini, J; Gago, F; Liekens, S; Vande Voorde, J; Vrancken, K | 1 |
| Gu, M; Ma, S; Zhang, NQ; Zhao, L; Zheng, XY | 1 |
| Gonen, I; Ozdemir, D; Sahin, A; Sarıtas, A; Turan, H | 1 |
| Stiefelhagen, P | 1 |
| Cai, X; Dong, X; He, A; Sun, Y; Xu, K; Zhang, N; Zheng, C; Zheng, X | 1 |
| Garcia-Estevez, DA | 1 |
| Kittas, C; Kouloukoussa, M; Palaiologou, M; Staurianeas, N; Tiniakos, DG; Zografakis, C | 1 |
| Bohn, K; Gentner, E; Mertens, T; Sauerbrei, A; Schubert, A; Schwarz, M | 1 |
| Arnold, RD; Chavre, S; Chu, CK; De, C; Hagen, FK; Liu, D; Moffat, JF; Singh, US; White, C; Zheng, B | 1 |
| Andrei, G; Coen, N; Duraffour, S; Snoeck, R; Topalis, D | 1 |
| Buturak, A; Gorgulu, S; Norgaz, T | 1 |
| Cornvik, T; Dahlroth, SL; Hew, K; Nordlund, P; Pan, LX; Veerappan, S | 1 |
| Balzarini, J; Brancale, A; Kandil, S; McGuigan, C; Rat, S; Westwell, AD | 1 |
| Albízuri-Prado, MF; Arranz Sánchez, D; Gómez-Fernández, C; Herranz Pinto, P; Sánchez-Orta, A | 1 |
| Cai, Y; Chen, S; Du, C; Lai, W; Liao, Y; Qin, C; Xie, S; Xie, X; Yang, C; Zheng, X; Zhou, J; Zhu, Y | 1 |
| Andrei, G; Chen, X; Liu, NN; Schols, D; Snoeck, R; Wen, YN; Wu, QP; Xiang, YH; Zhang, QS; Zhang, ZF; Zhang, ZY | 1 |
| Gu, M; Jiang, H; Sun, Y; Zheng, X | 1 |
| García Herrera, AN; Moncayola Vicén, JC | 1 |
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| Goodman, AL; Wegmann, R; Zimmermann, M; Zimmermann-Kogadeeva, M | 1 |
| Fujii, H; Fukushi, S; Harada, S; Inagaki, T; Mizuguchi, M; Nguyen, PHA; Saijo, M; Shibamura, M; Yamada, S | 1 |
33 review(s) available for bromodeoxyuridine and brivudine
| Article | Year |
|---|---|
Promising new antiviral drugs.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Herpes Simplex; Herpes Zoster; Humans; Interferons; Phosphonoacetic Acid; Ribavirin; Thymidine; Zidovudine | 1988 |
[Therapy of herpes simplex encephalitis].
Topics: Acyclovir; Anti-Bacterial Agents; Antiviral Agents; Brain Edema; Bromodeoxyuridine; Dexamethasone; Drug Therapy, Combination; Encephalitis; Ganciclovir; Herpes Simplex; Humans; Immunoglobulins; Interferons; Vidarabine | 1988 |
Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Transformation, Viral; Genes, Viral; Humans; Simplexvirus; Thymidine Kinase | 1989 |
[Mechanisms of antiherpes drugs and drug resistant virus--effect of BVDU on varicella zoster virus replication].
Topics: Acyclovir; Bromodeoxyuridine; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Herpesvirus 3, Human; Nucleic Acid Synthesis Inhibitors; Nucleosides; Simplexvirus; Thymidine Kinase; Virus Replication | 1985 |
Towards a selective chemotherapy of virus infections. Development of bromovinyldeoxyuridine as a highly potent and selective antiherpetic drug.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; DNA-Directed DNA Polymerase; Herpesviridae Infections; Humans; Mice; Structure-Activity Relationship; Thymidine Kinase; Viral Proteins | 1986 |
The antiviral spectrum of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Antiviral Agents; Bromodeoxyuridine; Cytomegalovirus; DNA Viruses; Herpesvirus 1, Bovine; Herpesvirus 1, Equid; Herpesvirus 1, Suid; Herpesvirus 2, Saimiriine; Herpesvirus 3, Human; Herpesvirus 4, Human; Insect Viruses; Simplexvirus | 1984 |
Physical and biological consequences of incorporation of antiviral agents into virus DNA.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cytarabine; Dideoxynucleosides; DNA, Viral; Idoxuridine; Protein Biosynthesis; Ribavirin; Simplexvirus; Structure-Activity Relationship; Thymidine; Thymine Nucleotides; Transcription, Genetic; Vidarabine | 1984 |
Interactions between virus and antiviral compounds in the host cell.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Cytomegalovirus; Deoxyribonucleotides; Diphosphates; DNA Replication; DNA, Viral; Drug Resistance, Microbial; Embryo, Mammalian; Herpesviridae; Herpesvirus 4, Human; Humans; Idoxuridine; Kidney; Lung; Nucleic Acid Synthesis Inhibitors; Nucleosides; Phosphorylation; Simplexvirus; Thymidine; Thymidine Kinase | 1984 |
Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chemical Phenomena; Chemistry; Disease Models, Animal; Drug Resistance, Microbial; Fibroblasts; Herpesvirus 3, Human; Humans; Mice; Pyrimidine Nucleosides; Rabbits; Simplexvirus; Structure-Activity Relationship | 1984 |
Antiviral agents: the road from scepticism to efficacy.
Topics: Acyclovir; Amantadine; Antiviral Agents; Bromodeoxyuridine; Clinical Trials as Topic; Guanine; Hepatitis B; Herpesviridae Infections; Humans; Interferons; Ketones; Neoplasms; Phosphonoacetic Acid; Vidarabine; Virus Diseases | 1981 |
Drug therapy. Treatment of herpesvirus infections.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Chickenpox; Herpes Zoster; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Immune Tolerance; Interferon Type I; Interferons; Vidarabine | 1983 |
Herpes virus infections in patients with neoplastic disease. Diagnosis and therapy.
Topics: Acyclovir; Antineoplastic Agents; Antiviral Agents; Bone Marrow Transplantation; Bromodeoxyuridine; Cloning, Molecular; Cytomegalovirus Infections; Herpes Simplex; Herpes Zoster; Herpesviridae Infections; Humans; Infectious Mononucleosis; Interferons; Kidney Transplantation; Leukemia; Lymphopenia; Neoplasms; Pulmonary Fibrosis; Vidarabine | 1984 |
Antiviral chemotherapy.
Topics: Acyclovir; Amantadine; Animals; Antiviral Agents; Bromodeoxyuridine; Female; Hepatitis B; Herpes Genitalis; Herpes Simplex; Herpes Zoster; Humans; Idoxuridine; In Vitro Techniques; Interferons; Male; Neoplasms; Papillomaviridae; Respiratory Tract Infections; Ribavirin; Rimantadine; Tumor Virus Infections; Vidarabine | 1984 |
Recurrent herpes simplex: the outlook for systemic antiviral agents.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Genes, Viral; Guanine; Herpes Simplex; Humans; Mice; Recurrence; Simplexvirus; Thymidine Kinase; Virus Replication | 1981 |
Nucleoside analogues as antiviral agents.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Cytarabine; Deoxyuridine; Guanine; Herpesviridae Infections; Humans; Idoxuridine; Nucleosides; Ribavirin; Thymidine; Virus Diseases; Viruses | 1981 |
Antiherpes drugs: promises and pitfalls.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cytarabine; Drug Resistance, Microbial; Herpesviridae Infections; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Vidarabine | 1984 |
The relative merits and drawbacks of new nucleoside analogues with clinical potential.
Topics: Acyclovir; Animals; Antiviral Agents; Biotransformation; Bromodeoxyuridine; Cytarabine; DNA-Directed RNA Polymerases; Ganciclovir; Humans; Idoxuridine; Nucleic Acid Synthesis Inhibitors; Nucleic Acids; Nucleosides; Ribavirin; Trifluridine; Vidarabine; Viruses | 1984 |
Antivirals for the treatment of herpesvirus infections.
Topics: Acyclovir; Antiviral Agents; Belgium; Bromodeoxyuridine; Cidofovir; Cytomegalovirus Infections; Cytosine; Ganciclovir; Guanine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds | 1993 |
Antiviral therapy of herpes simplex and varicella-zoster virus infections.
Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Chickenpox; Drug Resistance, Microbial; Encephalitis, Viral; Famciclovir; Herpes Genitalis; Herpes Labialis; Herpes Simplex; Herpes Zoster; Humans; Immunocompromised Host; Prodrugs; Simplexvirus; Valacyclovir; Valine | 1997 |
Recent developments in herpesvirus therapy.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Clinical Trials as Topic; Cytosine; Famciclovir; Foscarnet; Ganciclovir; Guanine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Thionucleotides; Valacyclovir; Valine | 2001 |
The role of antivirals in the management of neuropathic pain in the older patient with herpes zoster.
Topics: 2-Aminopurine; Acyclovir; Age Factors; Aged; Analgesics; Antiviral Agents; Bromodeoxyuridine; Drug Therapy, Combination; Famciclovir; Herpes Zoster; Humans; Neuralgia; Pain Measurement; Valacyclovir; Valine | 2003 |
Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Herpesviridae Infections; Humans | 2003 |
Brivudin (bromovinyl deoxyuridine).
Topics: Acute Disease; Antiviral Agents; Bromodeoxyuridine; Herpes Zoster; Humans; Randomized Controlled Trials as Topic | 2004 |
(E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).
Topics: Antiviral Agents; Bromodeoxyuridine; Drug Evaluation, Preclinical; Herpesvirus 1, Human; Herpesvirus 3, Human; Phosphorylation | 2005 |
Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster.
Topics: Antimetabolites; Antiviral Agents; Bromodeoxyuridine; Drug Interactions; Europe; Fluorouracil; Herpes Zoster; Herpesvirus 3, Human; Humans; Virus Replication | 2004 |
[Antiherpetic therapy].
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Drug Combinations; Famciclovir; Foscarnet; Ganciclovir; Humans; Idoxuridine; Keratitis, Herpetic; Oligonucleotides; Ophthalmic Solutions; Organophosphonates; Treatment Outcome; Valacyclovir; Valine; Vidarabine | 2005 |
Current management of herpes zoster: the European view.
Topics: Age Distribution; Aged; Aged, 80 and over; Antiviral Agents; Bromodeoxyuridine; Dose-Response Relationship, Drug; Drug Administration Schedule; Europe; Female; Herpes Zoster; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Pain Measurement; Prognosis; Recurrence; Risk Assessment; Severity of Illness Index; Sex Distribution; Treatment Outcome | 2005 |
New antiviral agents.
Topics: 2-Aminopurine; Acyclovir; Aminoquinolines; Antiviral Agents; Bromodeoxyuridine; Famciclovir; Fatty Alcohols; Ganciclovir; Guanine; Humans; Imiquimod; Valganciclovir; Virus Diseases | 2006 |
[Varicella-zoster virus infections--2: Zoster pain -- therapy and prevention].
Topics: 2-Aminopurine; Acute Disease; Acyclovir; Administration, Oral; Adult; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Anticonvulsants; Antidepressive Agents, Tricyclic; Antiviral Agents; Bromodeoxyuridine; Child; Drug Therapy, Combination; Famciclovir; Female; Herpes Zoster; Herpesvirus 3, Human; Herpesvirus Vaccines; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Pain; Prodrugs; Risk Factors; Sex Factors; Time Factors; Vaccination; Valacyclovir; Valine | 2006 |
Recommendations for the management of herpes zoster.
Topics: 2-Aminopurine; Acyclovir; Analgesics; Anti-Inflammatory Agents; Antiviral Agents; Bromodeoxyuridine; Famciclovir; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunocompetence; Immunocompromised Host; Valacyclovir; Valine | 2007 |
Interaction between capecitabine and brivudin in a patient with breast cancer.
Topics: Aged; Anemia, Aplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Breast Neoplasms; Bromodeoxyuridine; Capecitabine; Carcinoma, Ductal, Breast; Combined Modality Therapy; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Fatal Outcome; Female; Fluorouracil; Herpes Zoster; Humans; Onycholysis; Palliative Care; Peripheral Nervous System Diseases; Salvage Therapy; Stomatitis; Tooth Discoloration | 2010 |
Antivirals for management of herpes zoster including ophthalmicus: a systematic review of high-quality randomized controlled trials.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Bromodeoxyuridine; Famciclovir; Herpes Zoster; Herpesvirus 3, Human; Humans; Pain Management; Randomized Controlled Trials as Topic; Valacyclovir; Valine | 2012 |
Review for Disease of the Year: Treatment of Viral Anterior Uveitis: A Perspective.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Chikungunya Fever; Cytomegalovirus Infections; Eye Infections, Viral; Famciclovir; Herpes Simplex; Herpes Zoster Ophthalmicus; Humans; Rubella; Uveitis, Anterior; Valacyclovir; Zika Virus Infection | 2018 |
15 trial(s) available for bromodeoxyuridine and brivudine
| Article | Year |
|---|---|
Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.
Topics: Adolescent; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Child; Corneal Ulcer; Double-Blind Method; Female; Humans; Keratitis, Dendritic; Male; Middle Aged; Time Factors; Trifluridine; Wound Healing | 1991 |
Bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration: a double blind controlled study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Child; Corneal Ulcer; Double-Blind Method; Female; Follow-Up Studies; Humans; Keratitis, Dendritic; Male; Middle Aged; Prognosis; Recurrence; Trifluridine | 1991 |
Topical BVDU plus low-dosage steroids in the treatment of chronic relapsing zoster keratouveitis. A pilot study.
Topics: Administration, Topical; Adult; Bromodeoxyuridine; Chronic Disease; Clinical Trials as Topic; Dexamethasone; Drug Therapy, Combination; Female; Herpes Zoster Ophthalmicus; Humans; Keratitis; Male; Middle Aged; Ophthalmic Solutions; Pilot Projects; Recurrence; Uveitis | 1989 |
Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Bromodeoxyuridine; Child; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Interferon Type I; Keratitis, Dendritic; Male; Middle Aged; Recombinant Proteins | 1989 |
[Antiviral chemotherapy].
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Chickenpox; Child; Clinical Trials as Topic; Cytomegalovirus Infections; Double-Blind Method; Encephalitis; Female; Herpes Genitalis; Herpes Simplex; Herpes Zoster; Humans; Immunologic Deficiency Syndromes; Infant, Newborn; Pemphigoid Gestationis; Pregnancy; Vidarabine; Virus Diseases | 1986 |
Oral bromovinyldeoxyuridine therapy for herpes simplex and varicella-zoster virus infections in severely immunosuppressed patients: a preliminary clinical trial.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Child; Child, Preschool; Clinical Trials as Topic; Female; Herpes Simplex; Herpes Zoster; Humans; Immunosuppression Therapy; Leukemia; Lymphoma; Male; Middle Aged | 1986 |
Antiviral agents: the road from scepticism to efficacy.
Topics: Acyclovir; Amantadine; Antiviral Agents; Bromodeoxyuridine; Clinical Trials as Topic; Guanine; Hepatitis B; Herpesviridae Infections; Humans; Interferons; Ketones; Neoplasms; Phosphonoacetic Acid; Vidarabine; Virus Diseases | 1981 |
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the topical treatment of herpes simplex keratitis.
Topics: Administration, Topical; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Bromodeoxyuridine; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Keratitis, Dendritic; Male; Middle Aged; Recurrence; Wound Healing | 1981 |
Oral brivudin vs. intravenous acyclovir in the treatment of herpes zoster in immunocompromised patients: a randomized double-blind trial.
Topics: Acyclovir; Administration, Oral; Adolescent; Adult; Antibodies, Viral; Antiviral Agents; Bromodeoxyuridine; Double-Blind Method; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunocompromised Host; Injections, Intravenous; Male; Treatment Outcome | 1995 |
Efficacy of four antiviral agents in the treatment of uncomplicated herpetic keratitis.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Double-Blind Method; Humans; Idoxuridine; Keratitis, Herpetic; Ointments; Treatment Failure; Trifluridine | 1995 |
Oral brivudin in comparison with acyclovir for improved therapy of herpes zoster in immunocompetent patients: results of a randomized, double-blind, multicentered study.
Topics: Acyclovir; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Double-Blind Method; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunocompetence; Male; Middle Aged; Pain; Skin; Virus Replication | 2003 |
Oral brivudin in comparison with acyclovir for herpes zoster: a survey study on postherpetic neuralgia.
Topics: Acyclovir; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Double-Blind Method; Female; Follow-Up Studies; Herpes Zoster; Humans; Male; Middle Aged; Neuralgia; Prospective Studies | 2003 |
Brivudin compared with famciclovir in the treatment of herpes zoster: effects in acute disease and chronic pain in immunocompetent patients. A randomized, double-blind, multinational study.
Topics: 2-Aminopurine; Acute Disease; Administration, Oral; Aged; Antiviral Agents; Bromodeoxyuridine; Chronic Disease; Double-Blind Method; Europe; Famciclovir; Female; Herpes Zoster; Humans; Male; Middle Aged; Pain; Pain Measurement; Prospective Studies; Treatment Outcome | 2005 |
RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bromodeoxyuridine; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation, Preclinical; Female; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Male; Middle Aged; Models, Molecular; Molecular Chaperones; Pancreatic Neoplasms; Pilot Projects; Placebos; Rats; Rats, Sprague-Dawley; Sarcoma; Survival Analysis | 2011 |
Increased density of cutaneous nerve fibres in the affected dermatomes after herpes zoster therapy.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Biomarkers; Biopsy; Bromodeoxyuridine; Famciclovir; Female; Herpes Zoster; Humans; Immunohistochemistry; Male; Middle Aged; Nerve Fibers; Neuralgia, Postherpetic; Skin; Ubiquitin Thiolesterase; Valacyclovir; Valine | 2014 |
319 other study(ies) available for bromodeoxyuridine and brivudine
| Article | Year |
|---|---|
Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides.
Topics: Antiviral Agents; Bromodeoxyuridine; Foscarnet; Organophosphorus Compounds; Phosphonoacetic Acid | 1989 |
Synthesis and biological activities of 4-O-(difluoromethyl)-5-substituted-uracil nucleoside analogues.
Topics: Antiviral Agents; Arabinofuranosyluracil; Deoxyuridine; Humans; Simplexvirus; Structure-Activity Relationship; Uridine | 1988 |
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
Topics: Animals; Cell Line; Chemical Phenomena; Chemistry; Cytidine Deaminase; Drug Resistance, Microbial; Humans; Magnetic Resonance Spectroscopy; Nucleoside Deaminases; Pyrimidine Nucleosides; Simplexvirus; Thymidine Kinase; Tin; Tin Compounds | 1985 |
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Deoxyuracil Nucleotides; Drug Evaluation, Preclinical; Humans; Hydrocarbons, Halogenated; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Simplexvirus; Structure-Activity Relationship; Vaccinia virus; Vesicular stomatitis Indiana virus | 1986 |
Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Topics: Algorithms; Antineoplastic Agents; Databases, Factual; Discriminant Analysis; Models, Molecular; Nucleosides; Quantitative Structure-Activity Relationship | 2007 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Mice; Mice, Nude; Simplexvirus; Structure-Activity Relationship; Virus Replication | 1979 |
Pharmacokinetics of E-5-(2-bromovinyl)-2'-deoxyuridine in mice.
Topics: Animals; Antiviral Agents; Brain Chemistry; Bromodeoxyuridine; Floxuridine; Idoxuridine; Kinetics; Liver; Lung; Mice; Simplexvirus | 1979 |
Comparative evaluation of BVDU ((E)-5-(2-bromovinyl)-2'-deoxyuridine) in the treatment of experimental herpes simplex keratitis in rabbits.
Topics: Animals; Bromodeoxyuridine; Double-Blind Method; Idoxuridine; Keratitis, Dendritic; Ointments; Ophthalmic Solutions; Rabbits | 1979 |
Synthesis and biological activity of 5-(2,2-difluorocyclopropyl)-2'-deoxyuridine deoxyuridine diastereomers.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Carrier Proteins; Cell Survival; Cytopathogenic Effect, Viral; Deoxyuridine; Erythrocyte Membrane; Membrane Proteins; Mice; Nucleoside Transport Proteins; Simplexvirus; Stereoisomerism; Viral Plaque Assay | 1992 |
Analysis of toxic and mutagenic activities of antiherpesvirus nucleosides against HeLa cells and herpes simplex virus type 1.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cell Death; Cell Division; HeLa Cells; Humans; Mutagens; Nucleosides; Simplexvirus; Vidarabine; Virus Replication | 1992 |
Genotoxic properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).
Topics: Animals; Bromodeoxyuridine; CHO Cells; Cricetinae; Hypoxanthine Phosphoribosyltransferase; Liver; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Solvents; Tumor Cells, Cultured | 1992 |
cis-trans-isomerization of [E]-5-(2-bromovinyl)-2,2'-anhydrouridine in vivo in rats.
Topics: Animals; Antiviral Agents; Autoradiography; Biotransformation; Bromodeoxyuridine; Chromatography, High Pressure Liquid; Isomerism; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Rats; Rats, Inbred Strains; Simplexvirus; Spectrophotometry, Ultraviolet; Tissue Distribution; Uridine; Vinyl Compounds | 1991 |
Efficacy of 9-(2-phosphonylmethoxyethyl)adenine in the therapy of TK+ and TK- herpes simplex virus experimental keratitis.
Topics: Adenine; Administration, Topical; Animals; Antiviral Agents; Bromodeoxyuridine; Disease Models, Animal; Keratitis, Dendritic; Organophosphonates; Rabbits; Simplexvirus | 1991 |
Bromovinyldeoxyuridine treatment of herpetic keratitis clinically resistant to other antiviral agents.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antiviral Agents; Bromodeoxyuridine; Child; Child, Preschool; Corneal Ulcer; Drug Resistance, Microbial; Female; Follow-Up Studies; Humans; Infant; Keratitis, Dendritic; Male; Middle Aged; Ophthalmic Solutions; Prognosis; Recurrence; Simplexvirus | 1991 |
Selection of L cell sublines resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Animals; Antibodies, Viral; Antiviral Agents; Bromodeoxyuridine; Cell Line; Drug Resistance, Microbial; Mice; Selection, Genetic; Simplexvirus; Thymidine Kinase; Virus Replication | 1991 |
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
Topics: Antiviral Agents; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Deoxyuridine; Herpesvirus 3, Human; Molecular Structure; Simplexvirus; Structure-Activity Relationship; Thiophenes; Virus Replication | 1991 |
Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Animals; Antibodies, Monoclonal; Antiviral Agents; Bromodeoxyuridine; DNA, Viral; Drug Resistance, Microbial; Female; Fluorescent Antibody Technique; Humans; Simplexvirus; Thymidine Kinase; Virus Replication | 1991 |
Effects of phosphonylmethoxyalkyl-purine and -pyrimidine derivatives on TK+ and TK- HSV-1 keratitis in rabbits.
Topics: Adenine; Animals; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Hempa; Keratitis, Herpetic; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Simplexvirus; Thymidine Kinase | 1991 |
Antiviral activity of 5-iodo-2'-deoxyuridine and related drugs in human keratinocytes infected in vitro with herpes simplex virus type 1.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Drug Interactions; Guinea Pigs; Herpes Simplex; Humans; Idoxuridine; Keratinocytes; Simplexvirus; Thymidine; Thymidine Phosphorylase; Thymine; Zidovudine | 1991 |
(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine in the therapy of thymidine kinase-positive and -deficient herpes simplex virus experimental keratitis.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Disease Models, Animal; Drug Administration Schedule; Female; Keratitis, Dendritic; Male; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Random Allocation; Simplexvirus; Thymidine Kinase | 1991 |
Chronic ocular zoster.
Topics: Acyclovir; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Bromodeoxyuridine; Chronic Disease; Conjunctivitis; Dexamethasone; Drug Administration Routes; Female; Herpes Zoster Ophthalmicus; Humans; Keratitis, Dendritic; Male; Middle Aged; Prospective Studies; Scleritis; Skin Diseases; Uveitis, Anterior | 1991 |
Equine herpes virus 1 and pseudorabies virus resistance to 2'-fluoropyrimidine analogs and to bromovinyldeoxyuridine: implications for dTMP kinase activity.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; Drug Resistance, Microbial; Herpesviridae; Herpesvirus 1, Suid; Horses; Nucleoside-Phosphate Kinase; Pseudorabies; Pyrimidine Nucleosides; Substrate Specificity | 1990 |
Optimal treatment regimens for 5'-deoxy-5-fluorouridine, with or without (E)-5-(2-bromovinyl)-2'-deoxyuridine, against various tumors in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases | 1990 |
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on life-span and 5-fluorouracil metabolism in mice with hepatic metastases.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bromodeoxyuridine; Fluorouracil; Life Expectancy; Liver Neoplasms, Experimental; Mice; Mice, Inbred Strains | 1990 |
Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Cytidine Triphosphate; Deoxyuridine; DNA, Viral; Dose-Response Relationship, Drug; Drug Interactions; Humans; Purine Nucleotides; Pyrimidine Nucleotides; Simplexvirus; Tetrahydrouridine; Thymine Nucleotides; Virus Replication | 1990 |
Potent inhibitory effects of the 5'-triphosphates of (E)-5-(2-bromovinyl)-2'-deoxyuridine and (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on DNA polymerase gamma.
Topics: Animals; Antiviral Agents; Arabinonucleotides; Bromodeoxyuridine; Cell Line; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; DNA Replication; Escherichia coli; Humans; KB Cells; Kinetics; Nucleic Acid Synthesis Inhibitors; Simplexvirus | 1990 |
Susceptibility of human herpesvirus 6 to antivirals in vitro.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cells, Cultured; Cytomegalovirus; DNA Replication; Ganciclovir; Herpesvirus 6, Human; Humans; Immunoblotting; Nucleic Acid Hybridization; Phosphonoacetic Acid; Simplexvirus | 1990 |
Cytopathogenicity, drug susceptibility, and thymidine kinase activity of a retinovirulent herpes simplex virus type 2.
Topics: Acyclovir; Bromodeoxyuridine; Cells, Cultured; Cytopathogenic Effect, Viral; Humans; Simplexvirus; Substrate Specificity; Thymidine Kinase | 1990 |
Selective inhibition of thymidine kinase isoenzymes by (E)-5-(2-bromovinyl)-2-deoxyuridine.
Topics: Animals; Breast Neoplasms; Bromodeoxyuridine; Humans; Isoenzymes; Leukemia; Leukocytes, Mononuclear; Thymidine Kinase | 1990 |
Transcriptional activity of the herpes simplex virus genome during establishment, maintenance, and reactivation of in vitro virus latency.
Topics: Blotting, Northern; Bromodeoxyuridine; Cell Line; Cytomegalovirus; Immunoblotting; Interferon Type I; Nucleic Acid Hybridization; Poly A; Restriction Mapping; RNA; RNA, Messenger; Simplexvirus; Transcription, Genetic; Virus Replication | 1989 |
In vitro susceptibility of feline herpesvirus-1 to vidarabine, idoxuridine, trifluridine, acyclovir, or bromovinyldeoxyuridine.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cats; Cell Line; Herpesviridae; Idoxuridine; Neutralization Tests; Trifluridine; Vidarabine | 1989 |
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5'-deoxy-5-fluorouridine against adenocarcinoma 755 in mice. Correlation with pharmacokinetics of plasma 5-fluorouracil levels.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bromodeoxyuridine; Chromatography, High Pressure Liquid; Drug Synergism; Floxuridine; Fluorouracil; Half-Life; Male; Mice; Neoplasm Transplantation; Spectrophotometry, Ultraviolet | 1989 |
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Drug Resistance, Microbial; Herpes Simplex; Humans; Mice; Mutation; Nucleoside-Phosphate Kinase; Phosphotransferases; Simplexvirus; Temperature; Thymidine; Thymidine Kinase; Thymine Nucleotides; Trigeminal Ganglion; Tumor Cells, Cultured; Vero Cells | 1989 |
[Recent developments of antiherpes nucleoside analogue research].
Topics: Acyclovir; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Ganciclovir; Guanine; Guanosine Triphosphate; Herpesviridae Infections; Humans | 1989 |
(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity.
Topics: Antiviral Agents; Bromodeoxyuridine; Chromatography, High Pressure Liquid; DNA Transposable Elements; DNA, Viral; Dose-Response Relationship, Drug; Phosphorylation; Simplexvirus; Thymidine Kinase | 1989 |
[Isolation and in vitro and in vivo characteristics of a clone of a wild Aujeszky disease virus resistant to bromovinyldeoxyuridine].
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cats; Cattle; Dogs; Drug Resistance, Microbial; Female; Herpesvirus 1, Suid; Mice; Virus Cultivation | 1989 |
5-(2-bromoethyl)-2'-deoxyuridine: a selective inhibitor of herpes simplex viruses in vitro.
Topics: Antiviral Agents; Bromodeoxyuridine; Herpes Simplex; Humans | 1989 |
[BVDU therapy in herpes corneae].
Topics: Antiviral Agents; Bromodeoxyuridine; Female; Humans; Keratitis, Dendritic; Male; Ophthalmic Solutions; Wound Healing | 1989 |
Evaluation of antisera to 5-(2-bromo-E-ethenyl)-2'-deoxyuridine for the radioimmunoassay of a potent antiviral agent.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cross Reactions; Male; Rabbits; Radioimmunoassay; Spectrophotometry, Ultraviolet | 1989 |
Activation of latent herpes simplex virus type 2 infection in vitro requires a (E)-5-(2-bromovinyl)-2'-deoxyuridine-sensitive gene function.
Topics: Antiviral Agents; Bromodeoxyuridine; Cell Line; Gene Expression Regulation; Genes, Viral; Humans; Mutation; Recurrence; Simplexvirus; Temperature; Virus Activation; Virus Replication | 1987 |
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Division; Cell Line, Transformed; DNA; Genes, Viral; Idoxuridine; Mice; Simplexvirus; Thymidine Kinase; Thymidylate Synthase | 1987 |
[(E)-5-(2-bromovinyl)-2'-desoxyuridine--a new nucleoside analog with selective inhibitory action against herpesviruses. Studies in cell culture and animal experiments].
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cells, Cultured; Encephalitis; Herpesviridae; Herpesviridae Infections; Humans; Keratitis; Simplexvirus | 1987 |
The effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on DNA repair and mutagenesis of herpes simplex virus type 1.
Topics: Animals; Bromodeoxyuridine; DNA Repair; DNA, Viral; Genes, Viral; Mutation; Simplexvirus; Ultraviolet Rays; Vero Cells | 1987 |
[Combined action of nucleosides and alpha-interferon in inhibiting the reproduction of the herpes simplex type-II virus].
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Depression, Chemical; Drug Synergism; Humans; Interferon Type I; Nucleosides; Simplexvirus; Vidarabine; Virus Cultivation; Virus Replication | 1987 |
Intentional reactivation of latent ocular herpes infection during BVDU therapy.
Topics: Animals; Antibodies, Viral; Bromodeoxyuridine; Keratitis, Dendritic; Male; Rabbits; Simplexvirus; Virus Activation | 1987 |
Therapeutic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, caffeic acid oxidation product, and trisodiumphosphonoformate on cutaneous herpes simplex virus type 1 infection in guinea pigs.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Caffeic Acids; Cinnamates; Female; Foscarnet; Guinea Pigs; Herpes Simplex; Humans; Male; Organophosphorus Compounds; Oxidation-Reduction; Phosphonoacetic Acid; Simplexvirus | 1987 |
Evaluation of three methods for typing herpes simplex virus.
Topics: Animals; Antibodies, Monoclonal; Antiviral Agents; Bromodeoxyuridine; Deoxyribonuclease BamHI; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; DNA, Viral; Drug Resistance, Microbial; Electrophoresis, Agar Gel; Fluorescent Antibody Technique; Humans; Microbial Sensitivity Tests; Simplexvirus; Vero Cells | 1987 |
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chemical Phenomena; Chemistry; Deoxyuridine; Foscarnet; Herpes Simplex; Mice; Organophosphorus Compounds; Pharmaceutical Preparations; Phosphonoacetic Acid; Prodrugs; Rabbits; Simplexvirus; Thymidine; Vero Cells | 1988 |
Inhibition of terminal N- and O-glycosylation specific for herpesvirus-infected cells: mechanism of an inhibitor of sugar nucleotide transport across Golgi membranes.
Topics: Biological Transport; Bromodeoxyuridine; Cell Line; Galactosyltransferases; Glycosylation; Golgi Apparatus; Lectins; Nucleoside Diphosphate Sugars; Protein Processing, Post-Translational; Simplexvirus; Viral Envelope Proteins | 1988 |
Comparison of two bromovinyl nucleoside analogs, 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and E-5-(2-bromovinyl)-2'-deoxyuridine, with acyclovir in inhibition of Epstein-Barr virus replication.
Topics: Acyclovir; Arabinofuranosyluracil; Bromodeoxyuridine; DNA, Viral; Dose-Response Relationship, Drug; Drug Combinations; Herpesvirus 4, Human; Peptide Biosynthesis; Uridine; Virus Replication | 1988 |
[5-(2-bromovinyl)-2'-deoxyuridine therapy of herpes zoster diseases in patients with malignant primary diseases].
Topics: Adolescent; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Neoplasms; Opportunistic Infections | 1988 |
Efficacy of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil against acute herpes simplex virus keratitis and the establishment of latency: comparison with acyclovir and bromovinyldeoxyuridine.
Topics: Acute Disease; Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Keratitis, Dendritic; Rabbits; Simplexvirus; Uridine | 1987 |
Antiviral activity of 5'-PAA and 5'-PFA phosphate esters of 2'-deoxyuridines.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Survival; Foscarnet; Phosphonoacetic Acid; Structure-Activity Relationship; Thymidine Kinase; Vero Cells | 1986 |
Experimental thymidine kinase-deficient HSV-1 keratitis: therapeutic attempts.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Drug Evaluation, Preclinical; Floxuridine; Keratitis, Dendritic; Rabbits; Thymidine; Thymidine Kinase; Trifluridine | 1987 |
Chronic herpetic infection in an immunocompromised patient: report of a case.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Chronic Disease; Foscarnet; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Male; Middle Aged; Phosphonoacetic Acid; Stomatitis, Herpetic; Vidarabine | 1987 |
(E)-5-(2-bromovinyl)-2'-deoxyuridine not embryotoxic compared to related nucleoside analogues in chick embryos.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Chick Embryo; Floxuridine; Idoxuridine | 1987 |
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Foscarnet; Ganciclovir; Genes, Viral; Idoxuridine; Mutation; Phosphonoacetic Acid; Simplexvirus; Thymidine; Vidarabine | 1985 |
Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Idoxuridine; Kidney; Kinetics; Phosphorylation; Rabbits; Simplexvirus; Thymidine Kinase | 1985 |
Antiviral activity of CP-20,961 against herpes simplex viruses in vitro.
Topics: Acyclovir; Animals; Bromodeoxyuridine; Cells, Cultured; Diamines; Embryo, Mammalian; Foscarnet; Guinea Pigs; Phosphonoacetic Acid; Rabbits; Simplexvirus | 1985 |
Comparison of four methods for typing low-passage herpes simplex virus isolates.
Topics: Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Cell Line; Chick Embryo; DNA, Viral; Fluorescent Antibody Technique; Guinea Pigs; Simplexvirus; Virus Replication | 1985 |
Problems associated with the use of (E)-5-(2-bromovinyl)-2'-deoxyuridine for typing herpes simplex virus.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Simplexvirus; Thymidine Kinase; Viral Plaque Assay | 1985 |
Identification and typing of herpes simplex virus types 1 and 2 by monoclonal antibodies, sensitivity to the drug (E)-5-(2-bromovinyl)-2'-deoxyuridine, and restriction endonuclease analysis of viral DNA.
Topics: Antibodies, Monoclonal; Bromodeoxyuridine; DNA Restriction Enzymes; DNA, Viral; Fluorescent Antibody Technique; Radioimmunoassay; Simplexvirus | 1985 |
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on the growth and viral capsid antigen expression of Epstein-Barr virus-associated tumor (B-95-8) cells transplanted to nude mice.
Topics: Animals; Antigens, Viral; Bromodeoxyuridine; Capsid; Cell Line; Female; Herpesvirus 4, Human; Lymphocytes; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Tumor Virus Infections | 1985 |
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Cell Division; Cell Line; Cyclopentanes; Cytopathogenic Effect, Viral; Deoxycytidine; Deoxyuridine; Herpes Simplex; Humans; Mice; Mice, Hairless; Rabbits; Rats; Simplexvirus; Vaccinia virus; Vesicular stomatitis Indiana virus; Virus Cultivation | 1985 |
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Topics: Animals; Antiviral Agents; Bromodeoxycytidine; Bromodeoxyuridine; Cell Division; Cell Line; Female; Genes, Viral; Idoxuridine; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Phosphorylation; Simplexvirus; Thymidine Kinase; Transformation, Genetic | 1985 |
Chemotherapy of Aujeszky's disease (pseudorabies) in the mouse by means of nucleoside analogues: bromovinyldeoxyuridine, acyclovir, and dihydroxypropoxymethylguanine.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Cells, Cultured; Cricetinae; Female; Ganciclovir; Herpesvirus 1, Suid; Mice; Mice, Inbred BALB C; Pruritus; Pseudorabies; Time Factors; Viral Plaque Assay | 1985 |
Preclinical assessment of topical treatments of herpes simplex virus infection: 5% (E)-5-(2-bromovinyl)-2'-deoxyuridine cream.
Topics: Absorption; Acyclovir; Administration, Topical; Animals; Antiviral Agents; Bromodeoxyuridine; Dimethyl Sulfoxide; Female; Guinea Pigs; Herpes Simplex; Polyethylene Glycols; Simplexvirus; Skin; Viral Plaque Assay | 1985 |
Lack of oral HSV-2 in a college student population.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Viral; Bromodeoxyuridine; DNA, Viral; Face; Female; Herpes Labialis; Herpes Simplex; Humans; Male; Mouth; Sexual Behavior; Simplexvirus; Students; Virus Replication | 1985 |
HSV1-specific thymidylate kinase activity in infected cells.
Topics: Acyclovir; Animals; Bromodeoxyuridine; Cells, Cultured; Cricetinae; Deoxyuridine; Drug Resistance, Microbial; Herpes Simplex; Kinetics; Mice; Nucleoside-Phosphate Kinase; Phosphonoacetic Acid; Phosphorylation; Phosphotransferases; Substrate Specificity | 1985 |
Comparison of immunofluorescence with commercial monoclonal antibodies to biochemical and biological techniques for typing clinical herpes simplex virus isolates.
Topics: Antibodies, Monoclonal; Bromodeoxyuridine; Cells, Cultured; Fluorescent Antibody Technique; Herpes Simplex; Humans; Microbial Sensitivity Tests; Serotyping; Simplexvirus | 1985 |
The antiherpes drug (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) interferes with formation of N-linked and of O-linked oligosaccharides of the herpes simplex virus type 1 glycoprotein C.
Topics: Antiviral Agents; Bromodeoxyuridine; Cell Line; Oligosaccharides; Simplexvirus; Tunicamycin; Viral Envelope Proteins; Viral Proteins | 1985 |
Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Division; Cell Transformation, Viral; DNA; Idoxuridine; Iodine Radioisotopes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Simplexvirus; Thymidine Kinase; Thymidylate Synthase; Tritium | 1985 |
Drug resistance patterns of herpes simplex virus isolates from patients treated with acyclovir.
Topics: Acyclovir; Adult; Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; Drug Resistance, Microbial; Female; Ganciclovir; Humans; Male; Mice; Mice, Inbred BALB C; Simplexvirus; Stomatitis, Herpetic; Thymidine Kinase; Virulence | 1985 |
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on replication of Epstein-Barr virus in human lymphoblastoid cell lines.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cell Line; DNA; DNA, Viral; Dose-Response Relationship, Drug; Herpesvirus 4, Human; Humans; Idoxuridine; Kinetics; Lymphocytes; Molecular Weight; Peptide Biosynthesis; Peptides; Viral Proteins; Virus Replication | 1985 |
Therapy of varicella-zoster virus infection--mechanism of action of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Aminopterin; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chickenpox; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Microbial; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunoenzyme Techniques; In Vitro Techniques; Kinetics; Mutation; Thymidine Kinase; Viral Plaque Assay; Virus Replication | 1985 |
Differential metabolism of (E)-5-(2-bromovinyl)-2'-deoxyuridine in wild-type and drug-resistant herpes simplex virus-infected cells.
Topics: Animals; Bromodeoxyuridine; Cell Line; Drug Resistance, Microbial; Genes, Viral; Humans; Mutation; Phosphorylation; Simplexvirus; Thymidine Kinase | 1985 |
Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Cell Transformation, Viral; Cloning, Molecular; Genes; Genes, Viral; Mammary Neoplasms, Experimental; Mice; Rats; Simplexvirus; Thymidine Kinase | 1985 |
Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Bromouracil; Deoxyuridine; Herpes Simplex; Mice; Mice, Inbred BALB C; Rabbits; Simplexvirus; Thymine; Uridine; Virus Replication | 1986 |
Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Base Sequence; Binding Sites; Bromodeoxyuridine; Genes, Viral; Models, Molecular; Mutation; Simplexvirus; Thymidine Kinase | 1986 |
Prolonged herpes simplex virus latency in vitro after treatment of infected cells with acyclovir and human leukocyte interferon.
Topics: Acyclovir; Bromodeoxyuridine; Cell Line; Cell Survival; DNA, Viral; Drug Synergism; Herpes Simplex; Humans; Interferon Type I; Nucleosides; Simplexvirus; Time Factors; Virus Replication | 1986 |
Treatment of experimental herpes simplex virus type 1 encephalitis in mice with (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil: comparison with bromovinyl-deoxyuridine and acyclovir.
Topics: Acyclovir; Animals; Arabinofuranosyluracil; Bromodeoxyuridine; Cells, Cultured; Encephalitis; Female; Foscarnet; Herpes Simplex; Humans; Mice; Phosphonoacetic Acid; Simplexvirus; Uridine; Viral Plaque Assay | 1986 |
Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5-ethyl-2'-deoxyuridine and 5-(2-chloroethyl)-2'-deoxyuridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Bromouracil; Deoxyuridine; Half-Life; Humans; Male; Rabbits; Rats; Rats, Inbred Strains; Simplexvirus; Uracil | 1986 |
Therapeutic use of newer antiviral agents.
Topics: Acyclovir; Antigens, Viral; Antiviral Agents; Bone Marrow Transplantation; Bromodeoxyuridine; Cytomegalovirus; DNA, Viral; Ganciclovir; Herpes Simplex; Herpes Zoster; Herpesvirus 4, Human; Humans; Simplexvirus | 1986 |
Bovine herpes mammillitis therapy.
Topics: Antiviral Agents; Bromodeoxyuridine; Herpesviridae; Herpesvirus 2, Bovine; In Vitro Techniques; Phosphonoacetic Acid | 1986 |
Phosphorylation of nucleoside analogs by equine herpesvirus type 1 pyrimidine deoxyribonucleoside kinase.
Topics: Acyclovir; Adenosine Triphosphate; Animals; Bromodeoxyuridine; Cell Line; Cells, Cultured; Cytidine Triphosphate; Cytopathogenic Effect, Viral; Deoxycytidine; Ganciclovir; Herpesviridae; Herpesvirus 1, Equid; Mutation; Phosphorylation; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Substrate Specificity; Thymidine Kinase; Virus Replication | 1987 |
Effect of antiviral agents on replication of herpes simplex virus type 1 in brain cultures.
Topics: Acyclovir; Animals; Antiviral Agents; Brain; Bromodeoxyuridine; Cells, Cultured; Ganciclovir; Humans; Interferon Type I; Simplexvirus; Vero Cells; Vidarabine; Virus Replication | 1986 |
Incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine into deoxyribonucleic acids of varicella-zoster virus (TK+ and TK- strains)-infected cells.
Topics: Autoradiography; Biological Transport; Bromodeoxyuridine; Cells, Cultured; DNA, Viral; Dose-Response Relationship, Drug; Herpesvirus 3, Human; Humans; Idoxuridine; Nucleic Acid Hybridization; Thymidine; Thymidine Kinase; Time Factors; Virus Replication | 1987 |
Antiviral activity of various 1-beta-D-arabinofuranosyl-E-5-halogenovinyluracils and E-5-bromovinyl-2'-deoxyuridine against salmon herpes virus, Oncorhynchus masou virus (OMV).
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cell Line; Chromatography, High Pressure Liquid; DNA Polymerase II; Fish Diseases; Herpesviridae; Herpesviridae Infections; Nucleic Acid Synthesis Inhibitors; Salmon; Uridine | 1987 |
Serum and urine concentrations of oral bromovinyldeoxyuridine in humans as monitored by a bioassay system based on varicella-zoster virus focus inhibition.
Topics: Adult; Biological Assay; Bromodeoxyuridine; Cell Line; Herpesvirus 3, Human; Humans; Male; Middle Aged | 1987 |
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
Topics: Antiviral Agents; Bromodeoxyuridine; Deoxyuridine; Floxuridine; Simplexvirus; Structure-Activity Relationship | 1987 |
Efficacy of topical treatment for herpes simplex virus infections: predictions from an index of drug characteristics in vitro.
Topics: Acyclovir; Administration, Topical; Animals; Antiviral Agents; Bromodeoxyuridine; Deoxyuridine; Diffusion; Female; Guinea Pigs; Herpes Simplex; Idoxuridine; Pharmaceutical Vehicles; Skin Diseases; Trifluridine; Vidarabine | 1986 |
The antitumor potency of oral tegafur against adenocarcinoma 755 in mice is markedly enhanced by oral (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Drug Synergism; Metabolic Clearance Rate; Mice; Neoplasms, Experimental; Tegafur | 1987 |
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil and ftorafur against adenocarcinoma 755 in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Cysteine; Drug Evaluation, Preclinical; Drug Synergism; Fluorouracil; Male; Mice; Tegafur | 1987 |
An in vitro study of ophthalmic antiviral agent toxicity on rabbit corneal epithelium.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Survival; Cornea; Deoxyuridine; Epithelium; Idoxuridine; In Vitro Techniques; Rabbits; Thymidine; Trifluridine | 1988 |
Bioanalysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Antiviral Agents; Blood Proteins; Bromodeoxyuridine; Chromatography, Liquid; Humans; Protein Binding | 1988 |
Evaluation of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil (BrVaraU, VaraU) in the treatment of experimental herpes simplex virus type 1 keratitis in rabbits: comparison with (E)-5-(2-bromovinyl)-2'-deoxyuridine (BrVUdR).
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Drug Evaluation, Preclinical; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits | 1988 |
The chronic toxicity of bromovinyldeoxyuridine in beagle dogs.
Topics: Animals; Antiviral Agents; Blood Cell Count; Blood Chemical Analysis; Body Weight; Bromodeoxyuridine; Chemical and Drug Induced Liver Injury; Dogs; Eating; Female; Liver; Male; Organ Size; Sex Factors; Time Factors | 1988 |
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil against adenocarcinoma 755 in mice. Increased therapeutic index and correlation with increased plasma 5-fluorouracil levels.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Chromatography, High Pressure Liquid; Drug Synergism; Fluorouracil; Male; Mice | 1988 |
Combined effects of bromovinyldeoxyuridine and fractionated or continuous administration of 5-fluorouracil in P388 leukemia-bearing mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bromodeoxyuridine; Female; Fluorouracil; Lethal Dose 50; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred DBA | 1988 |
Inhibitory activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine on the salmonid herpesviruses, Oncorhynchus masou virus (OMV) and Herpesvirus salmonis.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cells, Cultured; DNA-Directed DNA Polymerase; Gonads; Herpesviridae; Salmonidae; Vidarabine; Virus Replication | 1988 |
Antiviral effects of dihydroxypropyladenine [RS)-DHPA) and bromovinyldeoxyuridine (BVDU) on plant viruses.
Topics: Adenine; Antiviral Agents; Bromodeoxyuridine; Mosaic Viruses; Plant Viruses; Plants | 1987 |
Comparative metabolism of E-5-(2-bromovinyl)-2'-deoxyuridine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil in herpes simplex virus-infected cells.
Topics: Arabinofuranosyluracil; Bromodeoxyuridine; Cell Line; Chromatography, High Pressure Liquid; Fibroblasts; Herpes Simplex; Humans; Osteosarcoma; Uridine | 1987 |
A comparison of the conformations adopted by some 5-bromovinyl-2'-deoxyuridines and a correlation with their antiviral properties: an X-ray study.
Topics: Antiviral Agents; Bromodeoxyuridine; Molecular Conformation; Structure-Activity Relationship; Substrate Specificity; Thymidine Kinase; X-Ray Diffraction | 1987 |
Combined antiviral effects of acyclovir or bromovinyldeoxyuridine and human immunoglobulin in herpes simplex virus-infected mice.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Combined Modality Therapy; Drug Administration Schedule; Drug Synergism; Herpes Simplex; Humans; Immunization, Passive; Mice; Mice, Hairless | 1987 |
High-performance liquid chromatographic analysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine and its metabolites in serum, urine and herpes simplex virus type-1 infected cells.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Herpes Simplex; Humans; Indicators and Reagents | 1986 |
Ocular penetration and efficacy of chloroethyldeoxyuridine against herpetic keratouveitis.
Topics: Animals; Anterior Chamber; Antiviral Agents; Bromodeoxyuridine; Deoxyuridine; Iritis; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits | 1986 |
Improvement of the bioavailability of the anti-herpes virus agent BVDU by use of 5'-O-alkoxycarbonyl derivatives with increased metabolic stability.
Topics: Animals; Antiviral Agents; Biological Availability; Bromodeoxyuridine; Herpes Simplex; Humans; In Vitro Techniques; Inactivation, Metabolic; Liver; Metabolic Clearance Rate; Mice; Structure-Activity Relationship | 1986 |
Enhancing effect of bromovinyldeoxyuridine on antitumour activity of 5-fluorouracil in mice bearing MOPC-315 plasmacytomas.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Dose-Response Relationship, Drug; Drug Interactions; Fluorouracil; Mice; Mice, Inbred BALB C; Plasmacytoma | 1986 |
Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Bromouracil; Cells, Cultured; Cricetinae; Cricetulus; DNA Repair; Liver; Male; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1985 |
Oral BVDU treatment of varicella and zoster in children with cancer.
Topics: Administration, Oral; Adolescent; Animals; Antiviral Agents; Bromodeoxyuridine; Chickenpox; Child; Child, Preschool; Female; Herpes Zoster; Humans; Male; Neoplasms | 1985 |
Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Leukemia L1210; Mice; Pyrimidine Nucleosides; Structure-Activity Relationship; Thymidine Kinase | 1985 |
Simultaneous high-performance liquid chromatographic assay for 5-(2-bromo-E-ethenyl)-2'-deoxyuridine and its metabolite, 5-(2-bromo-E-ethenyl)uracil, in plasma.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Bromouracil; Chromatography, High Pressure Liquid; Dogs; Humans; Rats; Reference Standards; Species Specificity | 1985 |
Evaluation of bromovinyldeoxyuridine-related compounds in the treatment of experimental herpes simplex keratitis.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits; Structure-Activity Relationship | 1985 |
5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
Topics: Animals; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Deoxyuridine; Dose-Response Relationship, Drug; Halogens; Herpes Simplex; Mice; Rats | 1985 |
Studies on the electrochemical behaviour of two anti-herpes uridines.
Topics: Antiviral Agents; Bromodeoxyuridine; Electrochemistry; Herpesviridae; Idoxuridine; Uridine | 1985 |
Experimental studies of latency in vitro by herpes simplex viruses.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Survival; Cells, Cultured; Cytopathogenic Effect, Viral; Fibroblasts; Genes, Viral; Humans; Interferon Type I; Lung; Models, Biological; Rats; Simplexvirus; Virus Activation | 1984 |
[Antiviral therapy of immunocompromised patients].
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Chickenpox; Cytomegalovirus Infections; Herpes Simplex; Herpes Zoster; Humans; Immune System Diseases; Vidarabine; Virus Diseases | 1984 |
More rapid isolation of herpes simplex virus in a continuous line of mink lung cells than in Vero or human fibroblast cells.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cytopathogenic Effect, Viral; Fibroblasts; Freezing; Humans; Lung; Mink; Simplexvirus | 1984 |
Influence of various experimental conditions on the inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on varicella-zoster virus replication in cell culture.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chlorocebus aethiops; Female; Fluorescent Antibody Technique; Herpesvirus 3, Human; Humans; Pregnancy; Time Factors; Virus Replication | 1984 |
Metabolic fate of (E)-5-(2-bromovinyl)-2'-deoxyuridine in herpes simplex virus- and mock-infected cells.
Topics: Antiviral Agents; Bromodeoxyuridine; Cell Line; Chromatography, High Pressure Liquid; Herpes Simplex; Humans; Kinetics; Simplexvirus | 1984 |
Induction of nuclear deoxyribopyrimidine triphosphatase and sensitivity of clinical isolates of herpes simplex virus to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Nucleus; Cells, Cultured; Chick Embryo; Enzyme Induction; Guinea Pigs; Pyrophosphatases; Simplexvirus | 1983 |
Antiherpes activity of some novel analogues of (E)-5-(2-bromovinyl)-2'-deoxyuridine (E-BrVUdR) in two different cell lines.
Topics: Antiviral Agents; Bromodeoxyuridine; Cells, Cultured; Herpes Simplex; Humans; Simplexvirus; Structure-Activity Relationship; Virus Replication | 1984 |
Properties of antiviral agents. 1.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Evaluation Studies as Topic; Foscarnet; Herpesviridae; Humans; Idoxuridine; Phosphonoacetic Acid; Trifluridine; Vidarabine; Viruses | 1984 |
Therapeutic effect of bromvinyldeoxyuridine and several nucleotides during experimental herpetic infection.
Topics: Animals; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Bromodeoxyuridine; Cyclic CMP; Cytarabine; Guinea Pigs; Herpesviridae Infections; Rabbits; Rats | 1984 |
E-5-(2-bromovinyl)-2'-deoxyuridine vs. interferon in the systemic treatment of infection with herpes simplex virus of athymic nude mice.
Topics: Animals; Bromodeoxyuridine; Dose-Response Relationship, Drug; Herpes Simplex; Interferons; Mice; Mice, Nude; Poly I-C; Time Factors | 1981 |
High efficiency latency and activation of herpes simplex virus in human cells.
Topics: Bromodeoxyuridine; Cells, Cultured; Cytarabine; Herpes Simplex; Humans; Interferons; Simplexvirus; Virus Activation; Virus Replication | 1982 |
Effect of eight antiviral drugs on the reactivation of herpes simplex virus in explant cultures of latently infected mouse trigeminal ganglia.
Topics: Acyclovir; Animals; Antibodies, Viral; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; Culture Media; Culture Techniques; Cytarabine; Foscarnet; Mice; Mice, Hairless; Neutralization Tests; Phosphonoacetic Acid; Simplexvirus; Thymidine; Trigeminal Nerve; Vidarabine Phosphate; Virus Activation | 1984 |
The sensitivity of acyclovir-resistant mutants of herpes simplex virus to other antiviral drugs.
Topics: Acyclovir; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Drug Resistance, Microbial; Foscarnet; Guanine; Microbial Sensitivity Tests; Mutation; Phosphonoacetic Acid; Simplexvirus; Thymidine; Trifluridine; Vidarabine | 1981 |
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Rabbits; Simplexvirus; Stereoisomerism; Structure-Activity Relationship; Vaccinia virus | 1981 |
On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Antiviral Agents; Bromodeoxyuridine; Carcinoma; Cell Line; DNA Polymerase II; DNA-Directed DNA Polymerase; Humans; Kinetics; Mouth Neoplasms; Simplexvirus; Virus Replication | 1981 |
Varicella-zoster virus in the human corneal endothelium: a case report.
Topics: Adult; Bromodeoxyuridine; Cornea; Herpes Zoster Ophthalmicus; Herpesvirus 3, Human; Humans; Keratitis; Male | 1980 |
Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cytosol; Deoxyuridine; Herpesvirus 3, Human; Humans; Idoxuridine; In Vitro Techniques; Mitochondria; Phosphorylation; Rabbits; Simplexvirus; Substrate Specificity; Thymidine Kinase | 1981 |
5-Methoxymethyldeoxyuridine-resistant mutants of herpes simplex virus type 1.
Topics: Acyclovir; Animals; Arabinonucleosides; Bromodeoxyuridine; Cell Line; Deoxyuridine; Drug Resistance, Microbial; Enzyme Induction; Guanine; Mice; Mutation; Phosphonoacetic Acid; Simplexvirus; Thymidine; Thymidine Kinase | 1981 |
Selective inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chlorocebus aethiops; Cytarabine; DNA; DNA, Viral; Guanine; Kidney; Simplexvirus | 1981 |
Differential inhibition of herpes simplex viruses, type 1 (HSV-1) an type 2 (HSV-2), by (E)-5-(2-X-vinyl)-2'-deoxyuridines.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Deoxyuridine; Fluorodeoxyuridylate; Idoxuridine; Rabbits; Simplexvirus; Structure-Activity Relationship | 1981 |
Effects of oral treatment with acyclovir and bromovinyldeoxyuridine on the establishment of maintenance of latent herpes simplex virus infection in mice.
Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Bromodeoxyuridine; Ganglia; Guanine; Herpes Simplex; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Simplexvirus; Time Factors | 1981 |
Repression and activation of the genome of herpes simplex viruses in human cells.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Cytarabine; DNA Restriction Enzymes; Genes, Viral; Humans; Kidney; Kinetics; Lung; Rabbits; Simplexvirus | 1981 |
Incorporation of E-5-(2-halovinyl)-2'-deoxyuridines into deoxyribonucleic acids of herpes simplex virus type 1-infected cells.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cell Transformation, Viral; Deoxyuridine; DNA Polymerase II; DNA Replication; DNA, Viral; Halogens; Idoxuridine; Kidney; Simplexvirus; Structure-Activity Relationship; Vinyl Compounds; Virus Replication | 1982 |
Chemotherapy of influenza and herpes virus infections.
Topics: Acyclovir; Amantadine; Antiviral Agents; Bromodeoxyuridine; Foscarnet; Guanine; Herpesviridae Infections; Humans; Influenza, Human; Phosphonoacetic Acid; Vidarabine | 1981 |
Resistance to antiviral drugs of herpes simplex virus isolated from a patient treated with acyclovir.
Topics: Acyclovir; Agammaglobulinemia; Antiviral Agents; Bromodeoxyuridine; Child; Drug Resistance, Microbial; Guanine; Humans; Male; Mutation; Simplexvirus; Thymidine Kinase | 1982 |
Comparison of thymidine kinase activities indiced in cells productively infected with herpesvirus saimiri and herpes simplex virus.
Topics: Acyclovir; Animals; Aotus trivirgatus; Bromodeoxyuridine; Cell Line; Chlorocebus aethiops; Enzyme Induction; Guanine; Herpesvirus 2, Saimiriine; Idoxuridine; Mutation; Simplexvirus; Thymidine; Thymidine Kinase | 1982 |
Activation of herpes simplex virus (HSV) type 1 genome by temperature-sensitive mutants of HSV type 2.
Topics: Bromodeoxyuridine; Cytomegalovirus; DNA Restriction Enzymes; DNA, Viral; Genes, Viral; Kinetics; Mutation; Simplexvirus; Temperature; Viral Plaque Assay; Virus Activation; Virus Cultivation; Virus Replication | 1982 |
Differentiation of herpes simplex virus types 1 and 2 by sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Chick Embryo; Culture Media; Guinea Pigs; Simplexvirus; Viral Plaque Assay; Virus Replication | 1982 |
In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Topics: Antiviral Agents; Bromodeoxyuridine; Herpes Zoster; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Phosphorylation | 1982 |
Differential phosphorylation of (E)-5-(2-bromovinyl)-2'-deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus.
Topics: Bromodeoxyuridine; Cytosol; Herpesvirus 3, Human; Kinetics; Phosphorylation; Simplexvirus; Thymidine; Thymidine Kinase | 1982 |
Effect of acyclovir, bromovinyldeoxyuridine, vidarabine, and L-lysine on latent ganglionic herpes simplex virus in vitro.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Culture Techniques; Guanine; Lysine; Mice; Mice, Inbred BALB C; Simplexvirus; Stereoisomerism; Trigeminal Ganglion; Trigeminal Nerve; Vidarabine | 1982 |
Different in vitro effects of dual combinations of anti-herpes simplex virus compounds.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chlorocebus aethiops; Drug Evaluation, Preclinical; Drug Interactions; Drug Synergism; Foscarnet; Guanine; Phosphonoacetic Acid; Simplexvirus; Trifluridine; Vidarabine | 1982 |
Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Guanine; Herpesvirus 3, Human; Idoxuridine; Trifluridine; Viral Plaque Assay | 1982 |
Efficiency and selectivity of (E)-5-(2-bromovinyl)-2'-deoxyuridine and some other 5-substituted 2'-deoxypyrimidine nucleosides as anti-herpes agents.
Topics: Adenoviruses, Simian; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Cycle; Cells, Cultured; Chick Embryo; Chlorocebus aethiops; Cricetinae; Drug Evaluation, Preclinical; Fibroblasts; Humans; Lung; Pseudorabies; Pyrimidine Nucleosides; Simplexvirus; Structure-Activity Relationship | 1982 |
Resistance of herpes simplex virus to adenine arabinoside and E-5-(2-bromovinyl)-2'-deoxyuridine: a physical analysis.
Topics: Acyclovir; Base Sequence; Bromodeoxyuridine; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Microbial; Genes, Viral; Guanine; Mutation; Phosphonoacetic Acid; Recombination, Genetic; Simplexvirus; Vidarabine | 1982 |
Inhibitory effect of E-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on herpes simplex virus replication and DNA synthesis.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; DNA; DNA, Viral; Kinetics; Nucleic Acid Synthesis Inhibitors; Rabbits; Simplexvirus; Thymine Nucleotides; Virus Replication | 1982 |
Isolation of bromovinyldeoxyuridine-resistant strains of herpes simplex virus and successful chemotherapy of mice infected with one such strain by using acyclovir.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Drug Resistance, Microbial; Herpes Simplex; Mice; Mice, Inbred BALB C; Simplexvirus; Thymidine Kinase; Virulence | 1982 |
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine against different herpes simplex virus strains in cell culture and against experimental herpes encephalitis in mice.
Topics: Animals; Antibodies, Viral; Bromodeoxyuridine; Cells, Cultured; Encephalitis; Female; Herpes Simplex; Male; Mice; Rabbits; Rats; Simplexvirus; Testis; Viral Plaque Assay | 1982 |
The relationship between incorporation of E-5-(2-Bromovinyl)-2'-deoxyuridine into herpes simplex virus type 1 DNA with virus infectivity and DNA integrity.
Topics: Bromodeoxyuridine; Centrifugation, Isopycnic; DNA, Viral; Dose-Response Relationship, Drug; Simplexvirus | 1983 |
Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays.
Topics: Bromodeoxyuridine; Cells, Cultured; Deoxyribonucleases; Deoxyuridine; Enzyme Induction; Fluorescent Antibody Technique; HeLa Cells; Humans; Idoxuridine; Microbial Sensitivity Tests; Simplexvirus; Thymidine Kinase | 1982 |
Effect of acyclovir and presence of cellular and viral thymidine kinase activity in herpes simplex virus infected cells. Brief report.
Topics: Acyclovir; Animals; Bromodeoxyuridine; Cell Division; Cell Line; Chlorocebus aethiops; Cytosol; Humans; Idoxuridine; Phosphonoacetic Acid; Simplexvirus; Thymidine Kinase | 1982 |
Comparison of biological, biochemical, immunological, and immunochemical techniques for typing herpes simplex virus isolates.
Topics: Bromodeoxyuridine; Culture Techniques; Fluorescent Antibody Technique; Humans; Neutralization Tests; Simplexvirus; Viral Plaque Assay | 1983 |
Alterations in substrate specificity and physicochemical properties of deoxythymidine kinase of a drug-resistant herpes simplex virus type 1 mutant.
Topics: Arabinonucleosides; Blood; Bromodeoxyuridine; Deoxyuridine; Drug Resistance, Microbial; Enzyme Induction; Hot Temperature; Mutation; Phosphorylation; Simplexvirus; Substrate Specificity; Thymidine; Thymidine Kinase | 1983 |
[Antiherpetics and their indications].
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Female; Herpesviridae Infections; Humans; Idoxuridine; Infant, Newborn; Male; Pregnancy; Trifluridine; Vidarabine | 1983 |
Epstein-Barr virus: inhibition of replication by three new drugs.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; DNA Replication; Herpesvirus 4, Human; Uridine; Virus Replication | 1983 |
Susceptibility of bovid herpesvirus 1 to antiviral drugs: in vitro versus in vivo efficacy of (E)-5-(2-Bromovinyl)-2'-deoxyuridine.
Topics: Animals; Antibodies, Viral; Antiviral Agents; Bromodeoxyuridine; Cattle; Cattle Diseases; Cells, Cultured; Herpesviridae; Herpesviridae Infections; Pasteurella; Temperature; Time Factors; Viral Plaque Assay; Virus Replication | 1983 |
Altered thymidine-thymidylate kinases from strains of herpes simplex virus with modified drug sensitivities to acyclovir and (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Drug Resistance, Microbial; Genetic Code; Nucleoside-Phosphate Kinase; Phosphorylation; Phosphotransferases; Simplexvirus; Substrate Specificity; Thymidine Kinase | 1983 |
Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on the proliferation of herpes simplex virus type 1-transformed and thymidine kinase-deficient mouse cells.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cell Line; Cell Transformation, Viral; Dose-Response Relationship, Drug; Mice; Simplexvirus; Thymidine Kinase | 1983 |
Synergistic antiviral activity of acyclovir and interferon on human cytomegalovirus.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cells, Cultured; Cytarabine; Cytomegalovirus; Drug Synergism; Humans; Interferon Type I; Kinetics; Vidarabine; Viral Plaque Assay | 1983 |
Herpes simplex acyclovir-resistant mutant in experimental keratouveitis.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cells, Cultured; Drug Resistance, Microbial; Keratitis, Dendritic; Male; Mutation; Rabbits; Simplexvirus; Vidarabine; Virulence | 1983 |
Serotyping of herpes simplex virus isolates: a comparison of BVDU sensitivities, indirect immunofluorescence with monoclonal antibodies, and indirect immunofluorescence with cross-adsorbed rabbit antibodies.
Topics: Animals; Antibodies, Monoclonal; Antiviral Agents; Bromodeoxyuridine; Cross Reactions; Fluorescent Antibody Technique; Humans; Immunosorbent Techniques; Rabbits; Serotyping; Simplexvirus | 1983 |
Oral antiviral drugs in experimental herpes simplex keratitis.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Female; Keratitis, Dendritic; Male; Microbial Sensitivity Tests; Rabbits; Simplexvirus | 1983 |
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on several parameters of Epstein-Barr virus infection.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Burkitt Lymphoma; Callitrichinae; Cell Line; Drug Evaluation, Preclinical; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Hybrid Cells; In Vitro Techniques; Thymidine; Virus Cultivation; Virus Replication | 1984 |
Incidence of herpes simplex virus types 1 and 2 in penile lesions of college men.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Viral; Bromodeoxyuridine; Deoxyribonuclease EcoRI; DNA Restriction Enzymes; DNA, Viral; Female; Herpes Genitalis; Humans; Male; Penile Diseases; Penis; Simplexvirus | 1984 |
The use of monoclonal antibodies to differentiate isolates of herpes simplex types 1 and 2 by neutralisation and reverse passive haemagglutination tests.
Topics: Antibodies, Monoclonal; Antibodies, Viral; Antiviral Agents; Bromodeoxyuridine; DNA Restriction Enzymes; Genes, Viral; Hemagglutination Tests; Neutralization Tests; Serotyping; Simplexvirus | 1984 |
A quantitative study of the effects of several nucleoside analogues on established herpes encephalitis in mice.
Topics: Acyclovir; Animals; Antiviral Agents; Brain; Bromodeoxyuridine; Encephalitis; Female; Ganciclovir; Herpes Simplex; Mice; Mice, Inbred BALB C; Simplexvirus; Time Factors; Trigeminal Ganglion; Virus Replication | 1984 |
Selectivity of antiviral effectiveness derived from differences of herpes simplex virus-coded thymidine kinases.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chlorocebus aethiops; Kidney; Simplexvirus; Thymidine Kinase | 1984 |
Synergistic antiviral effects of antiherpes compounds and human leukocyte interferon on varicella-zoster virus in vitro.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Drug Synergism; Foscarnet; Herpesvirus 3, Human; Humans; Interferon Type I; Microbial Sensitivity Tests; Phosphonoacetic Acid; Vidarabine | 1984 |
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on synthesis of herpes simplex virus type 1-specific polypeptides.
Topics: Animals; Bromodeoxyuridine; Chlorocebus aethiops; DNA, Viral; Glucosamine; Glycoproteins; Methionine; Peptide Biosynthesis; Phosphoproteins; Simplexvirus; Viral Proteins | 1984 |
Differential binding affinities of sugar-modified derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine for herpes simplex virus-induced and human cellular deoxythymidine kinases.
Topics: Bromodeoxyuridine; Cytosol; Deoxyuridine; Enzyme Induction; Humans; Mitochondria; Simplexvirus; Thymidine Kinase; Virus Replication | 1984 |
In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Deoxy Sugars; Deoxyglucose; Herpes Simplex; Idoxuridine; Male; Mice; Mice, Inbred BALB C; Simplexvirus; Trigeminal Ganglion; Trigeminal Nerve; Virus Activation; Virus Replication | 1984 |
Efficacy of bromovinyldeoxyuridine in the treatment of herpes simplex virus and varicella-zoster virus eye infections.
Topics: Animals; Bromodeoxyuridine; Herpes Simplex; Herpes Zoster Ophthalmicus; Humans; Keratitis; Keratitis, Dendritic; Rabbits; Uveitis | 1984 |
Baculovirus replication: inhibition of Trichoplusia ni multiple nuclear polyhedrosis virus by [E]-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Deoxycytidine Kinase; DNA Replication; DNA-Directed DNA Polymerase; Insect Viruses; Lepidoptera; Thymidine Kinase; Virus Replication | 1983 |
Corneal epithelial dysplasia after trifluridine use.
Topics: Age Factors; Aged; Antiviral Agents; Bromodeoxyuridine; Cornea; Corneal Diseases; Epithelium; Humans; Keratitis, Dendritic; Male; Microscopy, Phase-Contrast; Thymidine; Trifluridine | 1983 |
Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Topics: Administration, Topical; Animals; Antiviral Agents; Bromodeoxyuridine; Dimethyl Sulfoxide; Herpes Simplex; Mice; Mice, Hairless; Pharmaceutical Vehicles | 1984 |
Prospects for the design of new antiviral molecules: a chemist's view.
Topics: Antiviral Agents; Base Sequence; Bromodeoxyuridine; Genes, Viral; Interferon Inducers; Methylation; Protein Processing, Post-Translational; Receptors, Virus; RNA, Viral; Thymidine Kinase; Viral Proteins; Virus Replication; Viruses | 1984 |
Synthesis of 131I, 125I and 82Br labelled (E)-5-(2-halovinyl)-2'-deoxyuridines.
Topics: Antiviral Agents; Bromine; Bromodeoxyuridine; Encephalitis; Herpes Simplex; Humans; Idoxuridine; Iodine Radioisotopes; Isotope Labeling; Radioisotopes; Radionuclide Imaging | 1984 |
Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine treatment of severe herpes zoster in cancer patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Drug Evaluation; Female; Fever; Herpes Zoster; Humans; Male; Middle Aged; Neoplasms; Time Factors | 1984 |
Therapy of Herpes zoster infections.
Topics: Antiviral Agents; Bromodeoxyuridine; Herpes Zoster; Humans; Neoplasms | 1984 |
Inhibition of human and woodchuck hepatitis virus DNA polymerase by the triphosphates of acyclovir, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and E-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Deoxyuracil Nucleotides; DNA Polymerase II; Hepatitis B virus; Humans; Kinetics; Marmota; Nucleic Acid Synthesis Inhibitors; Phosphorus Radioisotopes; Ribonucleotides; Sciuridae; Structure-Activity Relationship | 1984 |
Oral and topical treatment of experimental HSV-1 genital herpes with (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Administration, Oral; Administration, Topical; Animals; Antiviral Agents; Bromodeoxyuridine; Female; Guinea Pigs; Herpes Genitalis; Male | 1984 |
Current aspects of anti-herpes research: problem, established work, and future goals.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Herpes Simplex; Humans; Recurrence | 1984 |
Inhibition of glycosylation of bovine herpesvirus 1 glycoproteins by the thymidine analog (E)-5-(2 Bromovinyl)-2'-deoxyuridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cattle; DNA, Viral; Glycoproteins; Herpesviridae; Phosphorylation; Protein Biosynthesis; Thymidine Kinase; Viral Proteins | 1983 |
Crystal and molecular structure of (E)-5-(2-bromovinyl-2'-deoxyuridine).
Topics: Bromodeoxyuridine; Models, Molecular; Molecular Conformation; Thymidine; X-Ray Diffraction | 1983 |
Comparison of flow cytometric analysis and [3H]thymidine incorporation for measurement of the effects of drug toxicity on lymphocyte stimulation.
Topics: Bromodeoxyuridine; Cytarabine; DNA; Drug-Related Side Effects and Adverse Reactions; Flow Cytometry; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Thymidine | 1983 |
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a good substrate for mammalian pyrimidine nucleoside phosphorylases.
Topics: Animals; Bromodeoxyuridine; Carcinoma, Ehrlich Tumor; Humans; Liver; Mice; Pentosyltransferases; Pyrimidine Phosphorylases; Spleen; Thymidine Phosphorylase | 1983 |
Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets.
Topics: Blood Platelets; Bromodeoxyuridine; Bromouracil; Chromatography, High Pressure Liquid; Deoxyuridine; Humans; In Vitro Techniques; Pentosyltransferases; Thymidine Phosphorylase; Thymine | 1983 |
Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on proliferation of human fibroblasts, peripheral blood mononuclear cells, and granulocyte-monocyte progenitor cells in vitro.
Topics: Antiviral Agents; Bromodeoxyuridine; Cell Division; Colony-Forming Units Assay; Fibroblasts; Granulocytes; Humans; In Vitro Techniques; Monocytes; Thymidine | 1983 |
Regeneration of the antiviral drug (E)-5-(2-bromovinyl)-2'-deoxyuridine in vivo.
Topics: Animals; Antiviral Agents; Biotransformation; Bromodeoxyuridine; Deoxyribonucleosides; Injections, Intraperitoneal; Kinetics; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1984 |
Modified polynucleotides. VI. Properties of a synthetic DNA containing the anti-herpes agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Antiviral Agents; Bromodeoxyuridine; Circular Dichroism; DNA; DNA Polymerase I; DNA Replication; Escherichia coli; Kinetics; Nucleic Acid Conformation; Nucleic Acid Denaturation; Temperature; Templates, Genetic | 1982 |
Sister chromatid exchange induced by anti-herpes drugs.
Topics: Antiviral Agents; Bromodeoxyuridine; Cells, Cultured; Crossing Over, Genetic; Fibroblasts; Humans; Idoxuridine; Lymphocytes; Sister Chromatid Exchange; Trifluridine | 1981 |
Experimental stroma herpes simplex keratitis. Influence of treatment with topical bromovinyldeoxyuridine and trifluridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Corneal Diseases; Disease Models, Animal; Drug Administration Schedule; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits; Thymidine; Trifluridine | 1982 |
Oral and topical treatment of experimental herpes simplex iritis with bromovinyldeoxyuridine.
Topics: Administration, Oral; Animals; Antiviral Agents; Betamethasone; Bromodeoxyuridine; Drug Synergism; Drug Therapy, Combination; Iritis; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits; Trifluridine | 1982 |
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the treatment of experimental herpes simplex virus encephalitis in mice.
Topics: Animals; Antiviral Agents; Brain; Bromodeoxyuridine; Encephalitis; Ganglia; Herpes Simplex; Male; Mice; Virus Replication | 1983 |
Preliminary results of oral BVDU treatment of herpes zoster ophthalmicus.
Topics: Administration, Oral; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Female; Herpes Zoster Ophthalmicus; Humans; Male; Middle Aged | 1981 |
Chemotherapeutic efficacy of E-5-(2-bromovinyl)-2'deoxyuridine for orofacial infection with herpes simplex virus type 1 in mice.
Topics: Acyclovir; Administration, Topical; Animals; Bromodeoxyuridine; Face; Guanine; Herpes Labialis; Herpes Simplex; Male; Mice; Mice, Inbred BALB C; Skin Diseases, Infectious; Time Factors; Trigeminal Ganglion | 1982 |
The synthesis and properties of some 5-substituted uracil derivatives.
Topics: Bromodeoxyuridine; Chemical Phenomena; Chemistry; Coliphages; Deoxyuridine; DNA, Bacterial; DNA, Viral; Escherichia coli; Methods; Mycoplasma; Uracil | 1980 |
Differential effects of E-5-(2-bromovinyl)-2'-deoxyuridine on infections with herpes simplex virus type 1 and type 2 in hairless mice.
Topics: Animals; Bromodeoxyuridine; Herpes Simplex; Mice; Mice, Nude | 1982 |
Influence of (E)-5-(2-bromovinyl)-2'-deoxyuridine on corneal epithelium healing.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cornea; Corneal Ulcer; Epithelium; Eye Injuries; Idoxuridine; Ophthalmic Solutions; Rabbits; Wound Healing | 1982 |
Treatment of experimental herpes simplex virus encephalitis with (E)-5-(2-bromovinyl)-2'-deoxyuridine in mice.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Encephalitis; Herpes Simplex; Mice | 1982 |
Effects of E-5-(2-bromovinyl)-2'-deoxyuridine and other selective anti-herpes compounds on the induction of retrovirus particles in mouse BALB/3T3 cells.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cells, Cultured; DNA; DNA-Directed DNA Polymerase; Herpesviridae; Mice; Retroviridae; Virus Activation | 1981 |
Ac2IDU, BVDU, and thymine arabinoside therapy in experimental herpes keratitis.
Topics: Animals; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Drug Evaluation, Preclinical; Idoxuridine; Keratitis, Dendritic; Male; Petrolatum; Rabbits; Sodium Chloride; Thymidine; Vidarabine | 1981 |
The synthesis and properties of some 5-substituted uracil derivatives.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Deoxyuridine; Drug Evaluation, Preclinical; Herpesviridae; Structure-Activity Relationship; Uracil | 1981 |
(E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Female; Idoxuridine; Keratitis; Keratitis, Dendritic; Male; Rabbits | 1980 |
Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine in severe herpes zoster.
Topics: Administration, Oral; Aged; Antiviral Agents; Bromodeoxyuridine; Female; Herpes Zoster; Humans; Male; Middle Aged | 1980 |
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents.
Topics: Acyclovir; Animals; Antiviral Agents; Brain Neoplasms; Bromodeoxyuridine; Gliosarcoma; Male; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Simplexvirus; Thymidine Kinase; Transfection; Tumor Cells, Cultured | 1995 |
5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies.
Topics: Antineoplastic Agents; Antiviral Agents; Blood Platelets; Bromodeoxyuridine; Cell Division; HeLa Cells; Herpesvirus 1, Human; Humans; Idoxuridine; Phosphorylation; Stereoisomerism; Thymidine Kinase | 1995 |
Methotrexate potentiates anti-herpes simplex virus type 1 activity of E-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Antiviral Agents; Bromodeoxyuridine; Cell Line; Drug Synergism; Herpesvirus 1, Human; Humans; Methotrexate | 1995 |
Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene.
Topics: Antiviral Agents; Bromodeoxyuridine; Cell Survival; Genetic Therapy; Glioma; Humans; Radiation Tolerance; Radiation-Sensitizing Agents; Simplexvirus; Thymidine Kinase; Transfection | 1994 |
Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.
Topics: Antiviral Agents; Bromodeoxyuridine; Chemical Phenomena; Chemistry, Physical; Deoxyuridine; Herpesvirus 1, Human; Molecular Structure; Stereoisomerism; Thermodynamics; Thiophenes; Thymidine Kinase; Viral Proteins; X-Ray Diffraction | 1994 |
Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Acyclovir; Amino Acid Sequence; Antiviral Agents; Base Sequence; Binding Sites; Bromodeoxyuridine; Deoxyuridine; Drug Resistance, Microbial; Herpesvirus 1, Human; Humans; Kinetics; Molecular Sequence Data; Phosphonoacetic Acid; Phosphorylation; Point Mutation; Sequence Analysis, DNA; Thymidine; Thymidine Kinase; Vidarabine | 1994 |
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
Topics: Animals; Antiviral Agents; Bromodeoxycytidine; Bromodeoxyuridine; Cell Survival; Genetic Therapy; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Mice; Mice, Inbred C3H; Substrate Specificity; Thiouridine; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Transfection; Tumor Cells, Cultured; Virus Replication | 1994 |
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms | 1994 |
5-Propyl-2-deoxyuridine induced interference with glycosylation in herpes simplex virus infected cells. Nature of PdU-induced modifications of N-linked glycans.
Topics: Agglutinins; Animals; Antiviral Agents; Biological Transport; Bromodeoxyuridine; Cell Line; Chlorocebus aethiops; Chromatography, Affinity; Chromatography, Gel; Deoxyuridine; Glycosylation; Golgi Apparatus; Humans; Infant; Lectins; Melanoma, Experimental; Mice; Neuraminidase; Nucleoside Diphosphate Sugars; Polysaccharides; Simplexvirus; Tumor Cells, Cultured; Viral Envelope Proteins | 1993 |
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Division; Humans; Mice; Molecular Structure; Phosphorylation; Simplexvirus; Thymidine Kinase; Transfection; Tumor Cells, Cultured | 1993 |
Efficacy of (S)-HPMPA against thymidine kinase-deficient herpes simplex virus-keratitis.
Topics: Adenine; Administration, Topical; Animals; Antiviral Agents; Bromodeoxyuridine; Deoxyuridine; Herpesvirus 1, Human; Keratitis, Herpetic; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Thymidine Kinase | 1987 |
In vitro sensitivity of macropodid herpesvirus 2 to selected anti-herpetic compounds.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinonucleosides; Bromodeoxycytidine; Bromodeoxyuridine; Cell Line; Cytarabine; Deoxycytidine; Herpesviridae; Herpesviridae Infections; Idoxuridine; Macropodidae; Microbial Sensitivity Tests; Neutralization Tests; Thymidine; Trifluridine; Vidarabine | 1996 |
Initiation of herpes simplex virus thymidine kinase polypeptides.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Base Sequence; Bromodeoxyuridine; Codon; Electrophoresis, Polyacrylamide Gel; Ganciclovir; Gene Expression; Herpesvirus 1, Human; Male; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; RNA, Messenger; Testis; Thymidine Kinase; Transfection | 1996 |
Evaluation of antiherpetic compounds using a gastric cancer cell line: pronounced activity of BVDU against herpes simplex virus replication.
Topics: Adenocarcinoma; Antiviral Agents; Bromodeoxyuridine; Colorimetry; Coloring Agents; Drug Evaluation, Preclinical; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Stomach Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Virus Replication | 1996 |
Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity.
Topics: Blotting, Western; Bromodeoxyuridine; Cytosine; Cytosine Deaminase; Deoxyuridine; Enzyme Inhibitors; Escherichia coli; Flucytosine; Ganciclovir; Gene Expression Regulation, Viral; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Gliosarcoma; Humans; Nucleoside Deaminases; Prodrugs; Radiation Tolerance; Recombinant Fusion Proteins; Simplexvirus; Thymidine Kinase; Tumor Cells, Cultured | 1997 |
Anti-recombinogenic and convertible co-mutagenic effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted pyrimidine nucleoside analogs in S. cerevisiae MP1.
Topics: Animals; Bromodeoxycytidine; Bromodeoxyuridine; Deoxycytidine; Dose-Response Relationship, Drug; Genes, Fungal; Heterozygote; Idoxuridine; Liver; Male; Mutagens; Mutation; Rats; Recombination, Genetic; Saccharomyces cerevisiae; Triethylenemelamine; Trifluridine | 1996 |
Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells.
Topics: 3T3 Cells; Animals; Antiviral Agents; Breast Neoplasms; Bromodeoxyuridine; Combined Modality Therapy; Female; Genetic Therapy; Genetic Vectors; Herpesvirus 3, Human; Humans; Mice; Mice, Nude; Rats; Thymidine Kinase; Tumor Cells, Cultured | 1997 |
Direct determination of drug content in semisolid formulations using step-scan FT-IR photoacoustic spectroscopy.
Topics: Anthralin; Bromodeoxyuridine; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Petrolatum; Pharmaceutical Vehicles; Spectroscopy, Fourier Transform Infrared | 1997 |
Focus luminescence assay: macroscopically visualized foci of human cytomegalovirus and varicella zoster virus infection.
Topics: Acyclovir; Antiviral Agents; Autoradiography; Bromodeoxyuridine; Cells, Cultured; Cytomegalovirus; Fibroblasts; Herpesvirus 3, Human; Humans; Immunoenzyme Techniques; Luminescent Measurements; Lung; Sensitivity and Specificity; Viral Plaque Assay | 1997 |
Antiviral efficacies of famciclovir, valaciclovir, and brivudin in disseminated herpes simplex virus type 1 infection in mice.
Topics: 2-Aminopurine; Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Disease Models, Animal; Famciclovir; Hepatitis, Animal; Herpes Zoster; Herpesvirus 1, Human; Liver; Mice; Mice, Inbred BALB C; Valacyclovir; Valine; Viral Plaque Assay; Virus Replication | 1997 |
Bromovinyldeoxyurdine treatment of outer retinal necrosis due to varicella-zoster virus: a case-report.
Topics: Administration, Oral; Aged; Antiviral Agents; Bromodeoxyuridine; Fluorescein Angiography; Herpes Zoster; Humans; Immunocompromised Host; Kidney Transplantation; Male; Retinal Necrosis Syndrome, Acute | 1996 |
Varicella vaccination in children after bone marrow transplantation.
Topics: Adolescent; Antibodies, Viral; Antiviral Agents; Bone Marrow Transplantation; Bromodeoxyuridine; Chickenpox; Chickenpox Vaccine; Child; Child, Preschool; Dose-Response Relationship, Drug; Follow-Up Studies; Herpes Zoster; Humans; Immune Tolerance; Immunoglobulin G; Retrospective Studies; Vaccination | 1997 |
Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.
Topics: Binding, Competitive; Bromodeoxyuridine; Cyclopentanes; Cytosol; Deoxycytidine; Deoxycytidine Kinase; Deoxyuridine; HeLa Cells; Humans; Mitochondria; Phosphorylation; Stereoisomerism; Substrate Specificity; Thymidine; Thymidine Kinase | 1997 |
[Synergistic antiherpetic effect of combined administration of para-aminobenzoic acid and modified nucleosides].
Topics: 4-Aminobenzoic Acid; Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Chlorocebus aethiops; Drug Resistance, Microbial; Drug Synergism; Herpesvirus 1, Human; Vero Cells; Vidarabine | 1997 |
In vitro and in vivo inhibition of murine gamma herpesvirus 68 replication by selected antiviral agents.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Chlorocebus aethiops; Cidofovir; Cytosine; Gammaherpesvirinae; Herpesviridae Infections; Mice; Mice, SCID; Organophosphonates; Organophosphorus Compounds; Vero Cells; Virus Replication | 1998 |
Assessment of correlation between skin target site free drug concentration and the in vivo topical antiviral efficacy in hairless mice for (E)-5-(2-bromovinyl)-2'-deoxyuridine and acyclovir formulations.
Topics: Acyclovir; Administration, Topical; Animals; Antiviral Agents; Azepines; Bromodeoxyuridine; Excipients; Female; Herpesvirus 1, Human; Mice; Mice, Hairless; Skin | 1998 |
(E)-5-(2'-bromovinyl)-2'-deoxyuridine inhibition of macropodid herpesvirus 1 in vitro.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Herpesviridae; Herpesviridae Infections; Marsupialia; Microbial Sensitivity Tests; Viral Plaque Assay | 1998 |
Pseudotumour of the tongue caused by herpes simplex virus type 2 in an HIV-1 infected immunosuppressed patient.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Bromodeoxyuridine; Granuloma, Plasma Cell; Herpes Genitalis; HIV-1; Humans; Immunocompromised Host; Male; Tongue Diseases | 1998 |
Determination of (E)-5-(2-bromovinyl)-2'-deoxyuridine in plasma and urine by capillary electrophoresis.
Topics: Antiviral Agents; Bromodeoxyuridine; Electrophoresis, Capillary; Humans; Reproducibility of Results; Sensitivity and Specificity | 1999 |
Development and validation of a bioanalytical assay for (E)-5-(2-bromovinyl)-2'deoxyuridine in plasma by capillary zone electrophoresis.
Topics: Antiviral Agents; Bromodeoxyuridine; Electrophoresis, Capillary; Humans; Reproducibility of Results; Sensitivity and Specificity | 1999 |
Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer.
Topics: Antiviral Agents; Bromodeoxyuridine; Colonic Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Fluorouracil; Ganciclovir; Genetic Therapy; Humans; Quinazolines; Simplexvirus; Thiophenes; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Breast Neoplasms; Bromodeoxyuridine; Female; Genetic Vectors; Herpesvirus 3, Human; Humans; Male; Mice; Mice, Nude; Rats; Rats, Inbred F344; Simplexvirus; Thymidine Kinase; Tumor Cells, Cultured | 2000 |
Antiviral activity of ganciclovir elaidic acid ester against herpesviruses.
Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Cytomegalovirus; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Foscarnet; Ganciclovir; Herpesvirus 3, Human; HIV-1; HIV-2; Humans; Mice; Simplexvirus | 2000 |
Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer.
Topics: 3T3 Cells; Adenocarcinoma; Animals; Antiviral Agents; Bromodeoxyuridine; Colonic Neoplasms; Fibrosarcoma; Ganciclovir; Genetic Vectors; Kanamycin Kinase; Mice; Mice, Inbred C57BL; Phosphorylation; Plasmids; Recombinant Fusion Proteins; Retroviridae; Simplexvirus; Thymidine Kinase; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2000 |
The bystander effect mediated by the new murine gammaherpesvirus 72--thymidine kinase/5'-fluoro-2'-deoxyuridine (MHV72-TK/5-FUdR) system in vitro.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Cell Death; Cell Survival; Coculture Techniques; Dose-Response Relationship, Drug; Floxuridine; Gammaherpesvirinae; Ganciclovir; Herpesvirus 1, Human; Mice; Nucleosides; Prodrugs; Rats; Reverse Transcriptase Polymerase Chain Reaction; Thymidine Kinase; Transfection; Tumor Cells, Cultured; Zidovudine | 2000 |
Novel mouse models for the investigation of experimental drugs with activity against human varicella-zoster virus.
Topics: Animals; Antiviral Agents; Biocompatible Materials; Bromodeoxyuridine; Cells, Cultured; DNA, Viral; Drug Evaluation, Preclinical; Female; Herpesvirus 3, Human; Humans; Male; Mice; Mice, SCID; Models, Animal; Time Factors; Umbilical Cord; Virus Replication | 2000 |
Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Catalysis; Cell Division; Cell Nucleus; Cladribine; Cytarabine; Deoxycytidine; Drosophila melanogaster; Gemcitabine; Humans; Inhibitory Concentration 50; Kinetics; Osteosarcoma; Pancreatic Neoplasms; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Promoter Regions, Genetic; Retroviridae; Substrate Specificity; Thymidine; Thymidine Kinase; Transduction, Genetic; Tumor Cells, Cultured | 2000 |
Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
Topics: Animals; Antiviral Agents; Blotting, Southern; Bromodeoxyuridine; Cell Division; DNA, Viral; Drug Resistance, Neoplasm; Female; Ganciclovir; Herpesvirus 1, Human; Mammary Neoplasms, Experimental; Mice; Reverse Transcriptase Polymerase Chain Reaction; Thymidine Kinase; Transfection; Tumor Cells, Cultured | 2000 |
Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Deoxyuracil Nucleotides; Disease Models, Animal; Drug Design; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Nude; Prodrugs; Thymidylate Synthase; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Xenograft model for identifying chemotherapeutic agents against papillomaviruses.
Topics: Animals; Antiviral Agents; Bovine papillomavirus 1; Bromodeoxyuridine; Cattle; DNA, Viral; Male; Mice; Mice, SCID; Skin; Skin Transplantation; Virion; Warts; Xenograft Model Antitumor Assays | 2001 |
Prevention of adriamycin-induced mdr1 gene amplification and expression in mouse leukemia cells by simultaneous treatment with the anti-recombinogen bromovinyldeoxyuridine.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; DNA Repair; DNA Replication; Doxorubicin; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, MDR; Humans; Leukemia; Mice; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2000 |
Bystander effects of cancer cell lines transduced with the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster and synergistic enhancement by hydroxyurea.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Cell Survival; Drosophila melanogaster; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxyurea; Phosphotransferases (Alcohol Group Acceptor); Transduction, Genetic; Tumor Cells, Cultured | 2001 |
[Controlling herpes zoster. End end to bullae].
Topics: Antiviral Agents; Bromodeoxyuridine; Dose-Response Relationship, Drug; Drug Administration Schedule; Herpes Zoster; Herpesvirus 3, Human; Humans; Virus Replication | 2001 |
(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Bromodeoxyuridine; Cell Death; Drug Resistance; Drug Synergism; Enzyme Induction; Ganciclovir; Humans; Mice; Simplexvirus; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured | 2001 |
Hamao Umezawa Memorial Award Lecture: "An Odyssey in the Viral Chemotherapy Field".
Topics: Antiviral Agents; Benzylamines; Bromodeoxyuridine; Cyclams; DNA Viruses; Enzyme Inhibitors; Heterocyclic Compounds; Humans; Interferons; Nucleosides; Polyelectrolytes; Polymers; RNA Viruses | 2001 |
Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol.
Topics: Amino Acid Sequence; Animals; Arabinonucleosides; Bromodeoxyuridine; Cell Death; Cell Nucleus; Cytosol; Drosophila melanogaster; Gene Expression; Genes, Insect; Genetic Therapy; Green Fluorescent Proteins; Humans; Luminescent Proteins; Osteosarcoma; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Recombinant Fusion Proteins; Retroviridae; Thymidine; Transduction, Genetic; Tumor Cells, Cultured | 2001 |
cycloSaligenyl-5-[(E)-2-bromovinyl]-2'-deoxyuridine monophosphate (cycloSal-BVDUMP) pronucleotides active against Epstein-Barr virus.
Topics: Antiviral Agents; Bromodeoxyuridine; Cell Division; Deoxyuracil Nucleotides; Herpesvirus 4, Human; Humans; Hydrolysis; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice.
Topics: Acyclovir; Animals; Antiviral Agents; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Ganciclovir; Genetic Therapy; Genetic Vectors; Glioma; Humans; Mice; Mice, Nude; Models, Chemical; Neoplasm Transplantation; Thymidine Kinase; Time Factors; Tumor Cells, Cultured | 2001 |
Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Acyclovir; Amides; Antiviral Agents; Bromodeoxyuridine; Cell Line; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Viral; Fibroblasts; Herpesvirus 3, Human; Humans; Lung; Molecular Structure; Phosphoric Acids; Simplexvirus; Structure-Activity Relationship; Vaccinia virus; Vesicular stomatitis Indiana virus | 2001 |
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.
Topics: Animals; Antiviral Agents; Binding Sites; Bromodeoxyuridine; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Escherichia coli; Fluorouracil; Herpesvirus 3, Human; Heterocyclic Compounds, 2-Ring; Humans; Mice; Models, Molecular; Nucleosides; Oxidoreductases; Substrate Specificity; Thymidine Phosphorylase | 2002 |
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antiviral Agents; Apoptosis; Bromodeoxyuridine; Carrier Proteins; Caspase 8; Caspase 9; Caspases; Cell Cycle; CHO Cells; Cricetinae; DNA; Fas Ligand Protein; Fas-Associated Death Domain Protein; Genome; Herpesvirus 3, Human; JNK Mitogen-Activated Protein Kinases; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Necrosis; Simplexvirus; Thymidine Kinase; Thymidylate Synthase; Transcription Factor AP-1; Transfection | 2003 |
Herpes zoster guideline of the German Dermatology Society (DDG).
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Analgesics; Antiviral Agents; Bone Marrow Diseases; Bromodeoxyuridine; Child; Child, Preschool; Contraindications; Drug Resistance, Viral; Drug Therapy, Combination; Female; Germany; Herpes Zoster; Herpes Zoster Ophthalmicus; Herpes Zoster Oticus; Herpesvirus 3, Human; Humans; Immunocompromised Host; Incidence; Male; Middle Aged; Neuralgia; Pain; Paresthesia; Pregnancy; Pregnancy Complications, Infectious; Severity of Illness Index; Virus Activation | 2003 |
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.
Topics: Acyclovir; Amino Acid Sequence; Binding Sites; Bromodeoxyuridine; Crystallography, X-Ray; Ganciclovir; Herpesvirus 3, Human; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Protein Binding; Sequence Alignment; Sequence Homology, Amino Acid; Simplexvirus; Structure-Activity Relationship; Substrate Specificity; Thymidine Kinase | 2003 |
Herpes zoster guidelines of the German Dermatological Society.
Topics: Aged; Animals; Antiviral Agents; Bromodeoxyuridine; Carcinogenicity Tests; Dermatology; Germany; Guidelines as Topic; Herpes Zoster; Herpesvirus 3, Human; Humans; Mice; Middle Aged; Rats; Societies, Medical | 2003 |
Inhibition of induced chemoresistance by cotreatment with (E)-5-(2-bromovinyl)-2'-deoxyuridine (RP101).
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Cisplatin; DNA-Binding Proteins; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Electrophoresis, Gel, Two-Dimensional; Fibroblasts; Ifosfamide; Methotrexate; Mice; Mitomycin; Mitoxantrone; NAD(P)H Dehydrogenase (Quinone); Rats; Rats, Sprague-Dawley; Sarcoma, Yoshida; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Vinblastine; Vinorelbine | 2003 |
[Brivudine as an alternative systemic therapy to aciclovir and ganciclovir in acute retinal necrosis syndrome due to varicella-zoster virus].
Topics: Acyclovir; Administration, Oral; Adolescent; Antiviral Agents; Bromodeoxyuridine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Ganciclovir; Herpes Zoster Ophthalmicus; Humans; Male; Middle Aged; Recurrence; Retinal Necrosis Syndrome, Acute; Retreatment; Treatment Failure | 2003 |
Lipid-mediated protein delivery of suicide nucleoside kinases.
Topics: Animals; Arabinonucleosides; Bone Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; CHO Cells; Cricetinae; Drosophila melanogaster; Endocytosis; Ganciclovir; Herpesvirus 1, Human; Humans; Liposomes; Osteosarcoma; Phosphatidylethanolamines; Phosphotransferases (Alcohol Group Acceptor); Recombinant Proteins; Thymidine; Thymidine Kinase | 2003 |
Synthesis, protonation behavior, conformational analysis, and regioselective enzymatic acylation of the novel diamino analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).
Topics: Acylation; Bromodeoxyuridine; Burkholderia cepacia; Candida; Hydrogen-Ion Concentration; Lipase; Magnetic Resonance Spectroscopy; Molecular Structure; Protons | 2003 |
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?
Topics: 2-Aminopurine; Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Foscarnet; Guanine; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Phenotype; Selection, Genetic; Thymidine Kinase; Viral Proteins | 2004 |
Functional expression of thymidine kinase in human leukaemic and colorectal cells, delivered as EGFP fusion protein by herpesvirus saimiri-based vector.
Topics: Animals; Antiviral Agents; Aotidae; Base Sequence; Bromodeoxyuridine; Cells, Cultured; Colorectal Neoplasms; Ganciclovir; Genetic Vectors; Green Fluorescent Proteins; Humans; Jurkat Cells; K562 Cells; Kidney; Leukemia; Molecular Sequence Data; Pancreatic Neoplasms; Recombinant Fusion Proteins; Simplexvirus; Thymidine Kinase; Transfection | 2004 |
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cells, Cultured; Drug Resistance, Viral; Famciclovir; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Nucleosides; Valacyclovir; Valine | 2005 |
Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Chlorocebus aethiops; Codon, Terminator; Drug Resistance, Viral; Frameshift Mutation; Models, Molecular; Phenotype; Selection, Genetic; Simplexvirus; Thymidine Kinase; Vero Cells | 2005 |
Insecticidal activity of the pyrimidine nucleoside analogue (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).
Topics: Animals; Bromodeoxyuridine; Dose-Response Relationship, Drug; Insecticides; Larva; Molecular Structure; Pupa; Spodoptera | 2005 |
Naphthyl phosphoramidate derivatives of BVdU as potential anticancer agents: design, synthesis and biological evaluation.
Topics: Amides; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Cell Line, Tumor; Colonic Neoplasms; Female; Humans; Male; Models, Chemical; Phosphoric Acids | 2005 |
Linear Darier disease with herpes zoster superinfection treated successfully by brivudine.
Topics: Antiviral Agents; Bromodeoxyuridine; Darier Disease; Herpes Zoster; Humans; Male; Middle Aged; Superinfection | 2006 |
Inhibitory efficacy of cyclosal-nucleoside monophosphates of aciclovir and brivudin on DNA synthesis of orthopoxvi ruses.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Chlorocebus aethiops; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; Orthopoxvirus; Polymerase Chain Reaction; Poxviridae Infections; Vero Cells; Virus Replication | 2006 |
Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts.
Topics: Arabinonucleosides; Biological Assay; Bromodeoxyuridine; Cell Extracts; Fibroblasts; Humans; Mitochondria; Phosphorylation; Protein Kinase Inhibitors; Substrate Specificity; Thymidine; Thymidine Kinase; Tumor Cells, Cultured | 2006 |
RP101 improves the efficacy of chemotherapy in pancreas carcinoma cell lines and pancreatic cancer patients.
Topics: Adult; Aged; Bromodeoxyuridine; Cell Line, Tumor; Cisplatin; Deoxycytidine; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gemcitabine; Humans; Killer Cells, Natural; Middle Aged; Pancreatic Neoplasms | 2006 |
Molecular modelling studies on the binding of some protides to the putative human phosphoramidase Hint1.
Topics: Amides; Bromodeoxyuridine; Catalytic Domain; Humans; Models, Molecular; Nerve Tissue Proteins; Phosphoric Acids; Protein Conformation; Substrate Specificity | 2007 |
6-Azathymidine-4'-thionucleosides: synthesis and antiviral evaluation.
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Ganciclovir; Magnetic Resonance Spectroscopy; Models, Molecular; Thionucleosides; Thymidine | 2008 |
Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
Topics: Adenosine Diphosphate; Animals; Antimetabolites; Bromodeoxyuridine; Cytarabine; Cytidine Triphosphate; Drosophila melanogaster; Drosophila Proteins; Feedback; Floxuridine; Guanosine Triphosphate; Hydrogen Bonding; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Structure, Secondary; Structure-Activity Relationship; Thymine Nucleotides; X-Ray Diffraction; Zalcitabine; Zidovudine | 2008 |
Synthesis and antitumor activity of a heterodinucleotide of BVDU and gemcitabine.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Bromodeoxyuridine; Cell Line, Tumor; Deoxycytidine; Drug Screening Assays, Antitumor; Gemcitabine; Rats; Sarcoma, Experimental | 2008 |
[Case report: again just an idiopathic facial nerve palsy?].
Topics: Acyclovir; Aged, 80 and over; Antiviral Agents; Bromodeoxyuridine; Diagnosis, Differential; Facial Paralysis; Female; Herpes Zoster Oticus; Humans; Treatment Outcome; Vertigo; Vomiting | 2008 |
5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts.
Topics: Animals; Bromodeoxyuridine; Complex Mixtures; Cytosol; Enzyme Inhibitors; Humans; Mice; Mitochondria; Organ Specificity; Phosphorylation; Substrate Specificity; Thymidine; Thymidine Kinase; Thymidine Phosphorylase | 2008 |
Perineal muco-cutaneous herpes zoster treated with brivudin.
Topics: Antiviral Agents; Bromodeoxyuridine; Child; Herpes Zoster; Humans; Male | 2008 |
Synthesis of nucleoside-based antiviral drugs in ionic liquids.
Topics: Antiviral Agents; Bromodeoxyuridine; Chemistry, Pharmaceutical; Drug Design; HIV; Humans; Imidazoles; Ionic Liquids; Models, Chemical; Nucleosides; Simplexvirus; Solubility; Solvents; Stavudine; Trifluridine | 2008 |
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy.
Topics: Amino Acid Sequence; Antiviral Agents; Bromodeoxyuridine; Calorimetry, Differential Scanning; Catalytic Domain; Crystallography, X-Ray; Dimerization; Humans; Models, Molecular; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Protein Structure, Quaternary; Substrate Specificity; Vaccinia virus | 2008 |
Fatal drug-drug interaction of brivudine and capecitabine.
Topics: Adverse Drug Reaction Reporting Systems; Aged, 80 and over; Antimetabolites, Antineoplastic; Antiviral Agents; Bromodeoxyuridine; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fatal Outcome; Female; Fluorouracil; Herpes Zoster; Humans; Switzerland | 2009 |
Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells.
Topics: Base Sequence; Bleomycin; Bromodeoxyuridine; Cell Line, Tumor; Chromatids; Chromosomes, Human; DNA Breaks, Double-Stranded; DNA Damage; DNA Mismatch Repair; DNA Primers; Gene Expression; Gene Silencing; HL-60 Cells; Humans; Models, Genetic; Poly(ADP-ribose) Polymerase Inhibitors; Rad51 Recombinase; Recombination, Genetic; RNA, Small Interfering | 2009 |
Acute hepatitis due to brivudin: a case report.
Topics: Adult; Alanine Transaminase; Antiviral Agents; Bilirubin; Bromodeoxyuridine; Chemical and Drug Induced Liver Injury; Herpes Simplex; Humans; Male | 2009 |
Epstein-Barr virus encephalitis after kidney transplantation and successful treatment with brivudine.
Topics: Antiviral Agents; Bromodeoxyuridine; Encephalitis, Viral; Herpesvirus 4, Human; Humans; Kidney Transplantation | 2010 |
Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Survival; Cells, Cultured; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Exodeoxyribonucleases; Foscarnet; Guanine; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Microbial Sensitivity Tests; Mutation, Missense; Organophosphonates; Oxidation-Reduction; Sequence Analysis, DNA; Staining and Labeling; Tetrazolium Salts; Thymidine Kinase; Viral Proteins | 2010 |
Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts.
Topics: Base Sequence; Blotting, Southern; Bromodeoxyuridine; Cell Death; Cell Line; Cell Proliferation; DNA, Mitochondrial; Drug Evaluation, Preclinical; Exons; Fibroblasts; Gene Expression Regulation; Humans; Kinetics; Molecular Sequence Data; Phosphorylation; Pyrimidine Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Thymidine Kinase | 2010 |
[64-year-old patient with efflorescences on the upper and lower legs].
Topics: Acyclovir; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Diagnosis, Differential; Esophageal Neoplasms; Exanthema; Herpes Zoster; Humans; Leg; Lymphoma, Mantle-Cell; Male; Middle Aged; Paraneoplastic Syndromes; Vasculitis, Leukocytoclastic, Cutaneous | 2010 |
Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet.
Topics: Acyclovir; Amino Acid Substitution; Antiviral Agents; Bromodeoxyuridine; Cell Line; Drug Resistance, Viral; Evolution, Molecular; Foscarnet; Genes, Viral; Herpes Zoster; Herpesvirus 3, Human; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Mutation; Open Reading Frames; Thymidine Kinase; Virus Replication | 2011 |
Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay.
Topics: Acyclovir; Amino Acid Substitution; Animals; Antiviral Agents; Bromodeoxyuridine; Chlorocebus aethiops; Drug Resistance, Viral; Ganciclovir; Gene Expression Regulation, Viral; Genetic Vectors; HEK293 Cells; Herpesvirus 1, Human; Humans; Microbial Sensitivity Tests; Mutation; Recombinant Proteins; Thymidine Kinase; Vero Cells; Viral Plaque Assay; Virus Replication | 2011 |
Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2.
Topics: Acyclovir; Adolescent; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Child; Child, Preschool; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Female; Foscarnet; Genotype; Guanine; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Infant; Male; Middle Aged; Mutation; Organophosphonates; Sequence Analysis, DNA; Thymidine Kinase; Viral Proteins | 2011 |
Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.
Topics: Amino Acid Sequence; Antiviral Agents; Breast Neoplasms; Bromodeoxyuridine; Computational Biology; Female; Humans; Idoxuridine; Kinetics; Molecular Sequence Data; Mycoplasma hyorhinis; Mycoplasma Infections; Protein Conformation; Pyrimidine Nucleosides; Sequence Homology, Amino Acid; Substrate Specificity; Thymidine Phosphorylase; Tumor Cells, Cultured; Uridine Phosphorylase; Viruses | 2012 |
Potent anticancer effects of lentivirus encoding a Drosophila melanogaster deoxyribonucleoside kinase mutant combined with brivudine.
Topics: Amino Acid Sequence; Animals; Antiviral Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Proliferation; Colorectal Neoplasms; Combined Modality Therapy; Drosophila melanogaster; Female; Flow Cytometry; Genetic Therapy; Genetic Vectors; Humans; Lentivirus; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins; Mutation; Phosphotransferases (Alcohol Group Acceptor); Prohibitins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Stomach Neoplasms; Tumor Cells, Cultured | 2012 |
Brivudin induced delirium: a case report.
Topics: Antiviral Agents; Bromodeoxyuridine; Delirium; Drug Monitoring; Herpes Zoster; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Treatment Outcome | 2012 |
[First headache, then swollen eye. A migraine this was not].
Topics: Antiviral Agents; Bromodeoxyuridine; Diagnosis, Differential; Edema; Eyelid Diseases; Herpes Zoster Ophthalmicus; Humans; Male; Migraine Disorders; Young Adult | 2012 |
Cytotoxic effects of adenovirus- and lentivirus-mediated expression of Drosophila melanogaster deoxyribonucleoside kinase on Bcap37 breast cancer cells.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Combined Modality Therapy; Drosophila Proteins; Female; Gene Expression; Genetic Therapy; Genetic Vectors; HEK293 Cells; Humans; Lentivirus; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Prohibitins; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
[Cervicodorsal myelitis secondary to infection by varicella zoster virus in an immunocompetent patient].
Topics: Acyclovir; Antiviral Agents; Arm; Athetosis; Bromodeoxyuridine; Drug Therapy, Combination; Herpes Zoster; Herpesvirus 3, Human; Humans; Hyperalgesia; Immunocompetence; Male; Methylprednisolone; Middle Aged; Movement Disorders; Myelitis; Neck; Neuralgia, Postherpetic; Somatosensory Disorders; Thorax; Virus Activation | 2013 |
Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes.
Topics: Acyclovir; Adolescent; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Child; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Exodeoxyribonucleases; Female; Frameshift Mutation; Guanine; Herpes Simplex; Herpesvirus 1, Human; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutagenesis, Insertional; Mutation, Missense; Point Mutation; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Thymidine Kinase; Viral Proteins; Young Adult | 2014 |
β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chickenpox; Dioxolanes; Drug Therapy, Combination; Fluorouracil; Foscarnet; Herpes Zoster; Herpesvirus 3, Human; Humans; Mice; Mice, Inbred BALB C; Mice, SCID; Nucleosides; Organ Culture Techniques; Skin; Uracil; Virus Replication | 2014 |
Spectrum of activity and mechanisms of resistance of various nucleoside derivatives against gammaherpesviruses.
Topics: Acyclovir; Amino Acid Sequence; Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Foscarnet; Ganciclovir; Guanine; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; Molecular Sequence Data; Protein Kinases; Rhadinovirus; Sequence Alignment; Structure-Activity Relationship; Thymidine Kinase; Viral Proteins | 2014 |
Brivudine induced coronary vasospasm as a manifestation of Kounis syndrome: First report.
Topics: Antiviral Agents; Bromodeoxyuridine; Coronary Vasospasm; Herpes Zoster; Humans; Male; Middle Aged; Syndrome | 2015 |
Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.
Topics: Antiviral Agents; Apoenzymes; Binding Sites; Bromodeoxyuridine; Herpesvirus 3, Human; Humans; Models, Molecular; Phosphorylation; Protein Binding; Protein Conformation; Thymidylate Synthase | 2015 |
ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites.
Topics: Amides; Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Humans; Mice; Neoplasms; Phosphoric Acids | 2016 |
A fatal drug interaction.
Topics: Antimetabolites, Antineoplastic; Antiviral Agents; Bromodeoxyuridine; Capecitabine; Drug Interactions; Fatal Outcome; Humans; Male; Middle Aged; Pancytopenia | 2017 |
Discovery of BVDU as a promising Drug for autoimmune diseases Therapy by Dendritic-cell-based functional screening.
Topics: Animals; Autoimmune Diseases; Bromodeoxyuridine; Cell Differentiation; Dendritic Cells; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Discovery; Encephalomyelitis, Autoimmune, Experimental; Humans; Interleukin-12; Interleukin-1beta; Interleukin-6; Mice, Inbred C57BL | 2017 |
Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV).
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytomegalovirus; Cytosine; Ganciclovir; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; Organophosphonates; Thymidine Kinase; Triazoles | 2017 |
Efficacy of lentivirus‑mediated Drosophila melanogaster deoxyribonucleoside kinase combined with (E)‑5‑(2‑bromovinyl)‑2'‑deoxyuridine or 1‑β‑D‑arabinofuranosylthymine therapy in human keloid fibroblasts.
Topics: Adult; Animals; Apoptosis; Arabinonucleosides; Bromodeoxyuridine; Bystander Effect; Cell Proliferation; Combined Modality Therapy; Drosophila melanogaster; Enzyme Assays; Female; Fibroblasts; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; Humans; Insect Proteins; Keloid; Lentivirus; Male; Middle Aged; Phosphotransferases (Alcohol Group Acceptor); Primary Cell Culture; Thymidine; Transgenes | 2018 |
[Lethal interaction between 5-fluorouracil and brivudine].
Topics: Aged; Antimetabolites, Antineoplastic; Antiviral Agents; Bromodeoxyuridine; Diagnostic Errors; Drug Interactions; Fatal Outcome; Fluorouracil; Herpes Zoster; Humans; Male | 2018 |
Engineered Thymidine-Active Deoxycytidine Kinase for Bystander Killing of Malignant Cells.
Topics: Animals; Apoptosis; Bromodeoxyuridine; Bystander Effect; Cell Line, Tumor; Deoxycytidine Kinase; Genes, Transgenic, Suicide; Genetic Therapy; HEK293 Cells; Humans; Male; Mice; Mice, SCID; Neoplasms; Prodrugs; Thymidine | 2019 |
Herpes zoster-associated paresis of the left arm.
Topics: Acyclovir; Administration, Intravenous; Aged; Antiviral Agents; Bromodeoxyuridine; Female; Herpes Zoster; Humans; Paresis; Physical Therapy Modalities | 2019 |
Separating host and microbiome contributions to drug pharmacokinetics and toxicity.
Topics: Animals; Bacteroides thetaiotaomicron; Biological Availability; Biotransformation; Bromodeoxyuridine; Clonazepam; Gastrointestinal Microbiome; Germ-Free Life; Mice | 2019 |
New Mechanism of Acyclovir Resistance in Herpes Simplex Virus 1, Which Has a UAG Stop Codon between the First and Second AUG Initiation Codons.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chlorocebus aethiops; Codon, Initiator; Codon, Terminator; Drug Resistance, Viral; Herpesvirus 1, Human; Humans; Microbial Sensitivity Tests; Mutation; Thymidine Kinase; Vero Cells; Viral Plaque Assay; Virus Replication | 2020 |