bromodeoxycytidine and 5-(2-iodovinyl)-2--deoxyuridine

bromodeoxycytidine has been researched along with 5-(2-iodovinyl)-2--deoxyuridine* in 1 studies

Other Studies

1 other study(ies) available for bromodeoxycytidine and 5-(2-iodovinyl)-2--deoxyuridine

Article	Year
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. FEBS letters, 1985, Jun-03, Volume: 185, Issue:1 Murine mammary carcinoma (FM3A TK-/HSV-1 TK+) cells, which are thymidine kinase (TK)-deficient but have been transformed with the herpes simplex virus type 1 (HSV-1) TK gene are inhibited in their growth by (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) and (E)-5-(2-bromovinyl)-2'-deoxycytidine (BVDC) at 0.5, 0.5 and 0.8 ng/ml, respectively; i.e., a concentration 5000 to 20 000-fold lower than that required to inhibit the growth of the corresponding wild-type FM3A/0 cells. Hence, transformation of tumor cells with the HSV-1 TK gene makes them particularly sensitive to the cytostatic action of BVDU and related compounds. Topics: Animals; Antiviral Agents; Bromodeoxycytidine; Bromodeoxyuridine; Cell Division; Cell Line; Female; Genes, Viral; Idoxuridine; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Phosphorylation; Simplexvirus; Thymidine Kinase; Transformation, Genetic	1985

Article

Year

Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.

FEBS letters, 1985, Jun-03, Volume: 185, Issue:1

Murine mammary carcinoma (FM3A TK-/HSV-1 TK+) cells, which are thymidine kinase (TK)-deficient but have been transformed with the herpes simplex virus type 1 (HSV-1) TK gene are inhibited in their growth by (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) and (E)-5-(2-bromovinyl)-2'-deoxycytidine (BVDC) at 0.5, 0.5 and 0.8 ng/ml, respectively; i.e., a concentration 5000 to 20 000-fold lower than that required to inhibit the growth of the corresponding wild-type FM3A/0 cells. Hence, transformation of tumor cells with the HSV-1 TK gene makes them particularly sensitive to the cytostatic action of BVDU and related compounds.

Topics: Animals; Antiviral Agents; Bromodeoxycytidine; Bromodeoxyuridine; Cell Division; Cell Line; Female; Genes, Viral; Idoxuridine; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Phosphorylation; Simplexvirus; Thymidine Kinase; Transformation, Genetic

1985