bromochloroacetic-acid and taxane

Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. Even months after the end of chemotherapy, many cancer patients complain of hair loss, a condition that is psychologically difficult to manage. CIA disturbs social and sexual interactions and causes anxiety and depression. Synthetic drugs protecting from CIA and endowed with hair growth stimulatory properties are prescribed with caution by oncologists. Hormones, growth factors, morphogens could unwontedly protect tumour cells or induce cancer cell proliferation and are thus considered incompatible with many chemotherapy regimens. Nutraceuticals, on the contrary, have been shown to be safe and effective treatment options for hair loss. We here show that polyphenols from

Topics: Administration, Topical; Alopecia; Animals; Antineoplastic Agents; Bridged-Ring Compounds; Dietary Supplements; Dinoprost; Fatty Acids, Unsaturated; Hair Follicle; Keratins; Male; Malus; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Plant Extracts; Polyphenols; Taxoids