brl-15572 and gingerol

brl-15572 has been researched along with gingerol* in 1 studies

Other Studies

1 other study(ies) available for brl-15572 and gingerol

Article	Year
Antiallodynic effect induced by [6]-gingerol in neuropathic rats is mediated by activation of the serotoninergic system and the nitric oxide-cyclic guanosine monophosphate-adenosine triphosphate-sensitive K Phytotherapy research : PTR, 2018, Volume: 32, Issue:12 The present study evaluated the possible antiallodynic effect induced by [6]-gingerol in rats with L5-L6 spinal nerve ligation (SNL). Moreover, we determined the possible mechanism underlying the antiallodynic effect induced by [6]-gingerol in neuropathic rats. The animals underwent L5-L6 SNL for the purpose of developing tactile allodynia. Tactile allodynia was measured with von Frey filaments. Intrathecal administration of [6]-gingerol reversed SNL-induced tactile allodynia. The [6]-gingerol-induced antiallodynic effect was prevented by the intrathecal administration of methiothepin (30 μg per rat; nonselective 5-hydroxytryptamine [5-HT] antagonist), WAY-100635 (6 μg per rat; selective 5-HT Topics: Adenosine Triphosphate; Analgesics; Animals; Biphenyl Compounds; Catechols; Cyclic GMP; Fatty Alcohols; Female; Guanosine Monophosphate; Hyperalgesia; Male; Neuralgia; Nitric Oxide; Piperazines; Piperidones; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonergic Neurons; Spiro Compounds	2018

Article

Year

Antiallodynic effect induced by [6]-gingerol in neuropathic rats is mediated by activation of the serotoninergic system and the nitric oxide-cyclic guanosine monophosphate-adenosine triphosphate-sensitive K

Phytotherapy research : PTR, 2018, Volume: 32, Issue:12

The present study evaluated the possible antiallodynic effect induced by [6]-gingerol in rats with L5-L6 spinal nerve ligation (SNL). Moreover, we determined the possible mechanism underlying the antiallodynic effect induced by [6]-gingerol in neuropathic rats. The animals underwent L5-L6 SNL for the purpose of developing tactile allodynia. Tactile allodynia was measured with von Frey filaments. Intrathecal administration of [6]-gingerol reversed SNL-induced tactile allodynia. The [6]-gingerol-induced antiallodynic effect was prevented by the intrathecal administration of methiothepin (30 μg per rat; nonselective 5-hydroxytryptamine [5-HT] antagonist), WAY-100635 (6 μg per rat; selective 5-HT

Topics: Adenosine Triphosphate; Analgesics; Animals; Biphenyl Compounds; Catechols; Cyclic GMP; Fatty Alcohols; Female; Guanosine Monophosphate; Hyperalgesia; Male; Neuralgia; Nitric Oxide; Piperazines; Piperidones; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonergic Neurons; Spiro Compounds

2018