Page last updated: 2024-09-02

bretazenil and zolpidem

bretazenil has been researched along with zolpidem in 13 studies

Compound Research Comparison

Studies
(bretazenil)
Trials
(bretazenil)
Recent Studies (post-2010)
(bretazenil)
Studies
(zolpidem)
Trials
(zolpidem)
Recent Studies (post-2010) (zolpidem)
1018141,825368683

Protein Interaction Comparison

ProteinTaxonomybretazenil (IC50)zolpidem (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.048
Translocator proteinRattus norvegicus (Norway rat)4.7
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.048
GABA theta subunitRattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.048

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's5 (38.46)18.2507
2000's6 (46.15)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S1
Sanger, DJ1
Ator, NA; Sannerud, CA1
Cluydts, R; De Cock, W; De Roeck, J; Dingemanse, J; Gieschke, R1
Hadingham, KL; Palmer, KJ; Thompson, SA; Wafford, KA; Whiting, PJ1
Atack, JR; McKernan, RM; Smith, AJ1
Członkowska, A; Nazar, M; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H1
Corsi, L; Neale, JH; Subramaniam, JR; Vicini, S; Whiting, PJ1
Danhof, M; Tuk, B; van Gool, T1
Mathiasen, L; Mirza, NR1
Mathiasen, LS; Mirza, NR; Rodgers, RJ1
Ahring, PK; Erichsen, HK; Larsen, JS; Lopez-Garcia, JA; Mirza, NR; Munro, G; Nielsen, EØ; Rivera-Arconada, I1
Cook, JM; Groenink, L; Hansen, HH; Mirza, NR; Nielsen, EØ; Olivier, B; van Oorschot, R; Vinkers, CH1

Trials

1 trial(s) available for bretazenil and zolpidem

ArticleYear
Effects of bretazenil vs. zolpidem and placebo on experimentally induced sleep disturbance in healthy volunteers.
    Methods and findings in experimental and clinical pharmacology, 1994, Volume: 16, Issue:9

    Topics: Adult; Analysis of Variance; Benzodiazepinones; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Noise, Transportation; Polysomnography; Psychomotor Performance; Pyridines; Sleep Stages; Sleep Wake Disorders; Sleep, REM; Zolpidem

1994

Other Studies

12 other study(ies) available for bretazenil and zolpidem

ArticleYear
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
    Journal of medicinal chemistry, 2000, Jan-13, Volume: 43, Issue:1

    Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship

2000
Further investigation of the stimulus properties of chlordiazepoxide and zolpidem. Agonism and antagonism by two novel benzodiazepines.
    Psychopharmacology, 1987, Volume: 93, Issue:3

    Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Discrimination Learning; Dose-Response Relationship, Drug; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Zolpidem

1987
Drug discrimination analysis of midazolam under a three-lever procedure. II: Differential effects of benzodiazepine receptor agonists.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Midazolam; Pyridines; Rats; Rats, Sprague-Dawley; Zolpidem

1995
Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.
    European journal of pharmacology, 1995, Nov-30, Volume: 291, Issue:3

    Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Base Sequence; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; Flunitrazepam; GABA Modulators; Humans; Molecular Sequence Data; Pyrazoles; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Proteins; Sequence Homology, Amino Acid; Triazolam; Xenopus; Zolpidem

1995
Benzodiazepine modulation of recombinant alpha1beta3gamma2 GABA(A) receptor function efficacy determination using the Cytosensor microphysiometer.
    European journal of pharmacology, 1998, Oct-23, Volume: 359, Issue:2-3

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Biosensing Techniques; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Eukaryotic Cells; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pyridines; Receptors, GABA-A; Recombinant Proteins; Time Factors; Zolpidem

1998
The role of the hippocampus and 5-HT/GABA interaction in the central effects of benzodiazepine receptor ligands.
    Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:5-6

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Brain; Conflict, Psychological; Dentate Gyrus; Dopamine; Drinking Behavior; Electroshock; Exploratory Behavior; Fenclonine; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Hydroxyindoleacetic Acid; Male; Microinjections; Midazolam; Motor Activity; Norepinephrine; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin; Zolpidem

1999
Ribozyme-mediated reduction of the GABA(A) receptor alpha1 subunit.
    Brain research. Molecular brain research, 2001, Aug-15, Volume: 92, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Cell Line; Cell-Free System; Down-Regulation; Humans; Mice; Molecular Sequence Data; Oligoribonucleotides, Antisense; Promoter Regions, Genetic; Protein Subunits; Pyridines; Rats; Receptors, GABA-A; Recombinant Fusion Proteins; RNA, Catalytic; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Transfection; Zolpidem

2001
Mechanism-based pharmacodynamic modeling of the interaction of midazolam, bretazenil, and zolpidem with ethanol.
    Journal of pharmacokinetics and pharmacodynamics, 2002, Volume: 29, Issue:3

    Topics: Animals; Benzodiazepinones; Drug Interactions; Electroencephalography; Ethanol; Male; Midazolam; Models, Biological; Protein Binding; Pyridines; Rats; Rats, Wistar; Zolpidem

2002
A comparison of chlordiazepoxide, bretazenil, L838,417 and zolpidem in a validated mouse Vogel conflict test.
    Psychopharmacology, 2005, Volume: 182, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepinones; Chlordiazepoxide; Conflict, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drinking Behavior; Drug Interactions; Electroshock; Fluorobenzenes; GABA Agents; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pyridines; Reaction Time; Reproducibility of Results; Time Factors; Triazoles; Water Deprivation; Zolpidem

2005
Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:3

    Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Cues; Discrimination Learning; Fluorobenzenes; GABA Modulators; Generalization, Psychological; Male; Piperazines; Protein Subunits; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Triazoles; Zolpidem

2006
Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:3

    Topics: Allosteric Regulation; Animals; Benzimidazoles; Benzodiazepinones; Diazepam; GABA Modulators; Humans; Inflammation; Isoxazoles; Neuralgia; Pyridines; Rats; Receptors, GABA-A; Zolpidem

2008
GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Benzodiazepinones; Body Temperature; Brain; Diazepam; DNA Primers; Drug Tolerance; Flumazenil; Hypnotics and Sedatives; In Situ Hybridization; Male; Mice; Mice, Mutant Strains; Pyridazines; Pyridines; Receptors, GABA-A; Triazoles; Zolpidem

2012