Compounds > bretazenil

Page last updated: 2024-09-02

bretazenil and midazolam

bretazenil has been researched along with midazolam in 10 studies

Compound Research Comparison

Studies (bretazenil)	Trials (bretazenil)	Recent Studies (post-2010) (bretazenil)	Studies (midazolam)	Trials (midazolam)	Recent Studies (post-2010) (midazolam)
101	8	14	9,834	3,191	3,301

Protein Interaction Comparison

Protein	Taxonomy	bretazenil (IC50)	midazolam (IC50)
Cytochrome P450 3A4	Homo sapiens (human)		2.7427

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (10.00)	18.7374
1990's	7 (70.00)	18.2507
2000's	2 (20.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Danhof, M; Kuck, MT; Mandema, JW	1
Järbe, TU; Rijnders, HJ; Slangen, JL	1
Cooper, SJ; Yerbury, RE	1
Ator, NA; Sannerud, CA	1
Acri, JB; Witkin, JM; Wong, G	1
Acri, JB; Barrett, JE; Gleeson, S; Witkin, JM	1
Członkowska, A; Nazar, M; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H	1
Bergman, J; Paronis, CA	1
Danhof, M; Tuk, B; van Gool, T	1
France, CP; McMahon, LR	1

Other Studies

10 other study(ies) available for bretazenil and midazolam

Article	Year
In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:1 Topics: Animals; Azepines; Benzodiazepinones; Drug Interactions; Electroencephalography; Infusions, Intravenous; Male; Midazolam; Rats; Rats, Inbred Strains	1992
The pentylenetetrazole-cue antagonist actions of bretazenil (Ro 16-6028) as compared to midazolam. Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:1 Topics: Animals; Benzodiazepinones; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Psychological; Male; Midazolam; Pentylenetetrazole; Rats; Rats, Inbred Strains	1991
The benzodiazepine partial agonists, Ro16-6028 and Ro17-1812, increase palatable food consumption in nondeprived rats. Pharmacology, biochemistry, and behavior, 1987, Volume: 28, Issue:4 Topics: Animals; Benzodiazepinones; Drug Interactions; Eating; Male; Midazolam; Motor Activity; Rats; Receptors, GABA-A	1987
Drug discrimination analysis of midazolam under a three-lever procedure. II: Differential effects of benzodiazepine receptor agonists. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1 Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Midazolam; Pyridines; Rats; Rats, Sprague-Dawley; Zolpidem	1995
Stereospecific transduction of behavioral effects via diazepam-insensitive GABAA receptors. European journal of pharmacology, 1995, May-24, Volume: 278, Issue:3 Topics: Animals; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Columbidae; Diazepam; Discrimination Learning; Flumazenil; GABA Modulators; Imidazoles; Male; Midazolam; Oxadiazoles; Radioligand Assay; Receptors, GABA-A; Sensitivity and Specificity; Stereoisomerism	1995
Blockade of behavioral effects of bretazenil by flumazenil and ZK 93,426 in pigeons. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:1 Topics: Animals; Behavior, Animal; Benzodiazepinones; Carbolines; Columbidae; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Male; Midazolam; Punishment; Receptors, GABA	1997
The role of the hippocampus and 5-HT/GABA interaction in the central effects of benzodiazepine receptor ligands. Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:5-6 Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Brain; Conflict, Psychological; Dentate Gyrus; Dopamine; Drinking Behavior; Electroshock; Exploratory Behavior; Fenclonine; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Hydroxyindoleacetic Acid; Male; Microinjections; Midazolam; Motor Activity; Norepinephrine; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin; Zolpidem	1999
Apparent pA2 values of benzodiazepine antagonists and partial agonists in monkeys. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3 Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Carbolines; Dose-Response Relationship, Drug; Electroshock; Feeding Behavior; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Kinetics; Male; Midazolam; Receptors, GABA-A; Reinforcement Schedule; Saimiri	1999
Mechanism-based pharmacodynamic modeling of the interaction of midazolam, bretazenil, and zolpidem with ethanol. Journal of pharmacokinetics and pharmacodynamics, 2002, Volume: 29, Issue:3 Topics: Animals; Benzodiazepinones; Drug Interactions; Electroencephalography; Ethanol; Male; Midazolam; Models, Biological; Protein Binding; Pyridines; Rats; Rats, Wistar; Zolpidem	2002
Differential behavioral effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys. British journal of pharmacology, 2006, Volume: 147, Issue:3 Topics: Animals; Benzodiazepines; Benzodiazepinones; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Fluorobenzenes; GABA Modulators; Macaca mulatta; Midazolam; Pregnanediones; Receptors, GABA-A; Triazoles	2006