Compounds > bretazenil
Page last updated: 2024-09-02

bretazenil and flunitrazepam

bretazenil has been researched along with flunitrazepam in 7 studies

Compound Research Comparison

Studies
(bretazenil)		Trials
(bretazenil)		Recent Studies (post-2010)
(bretazenil)		Studies
(flunitrazepam)		Trials
(flunitrazepam)		Recent Studies (post-2010) (flunitrazepam)
1018142,697298130

Protein Interaction Comparison

ProteinTaxonomybretazenil (IC50)flunitrazepam (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0016
GABA theta subunitRattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0016

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's4 (57.14)18.2507
2000's2 (28.57)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S1
Gibert-Rahola, J; Maldonado, R; Micó, JA; Valverde, O1
Bonetti, EP; Burkard, WP; Cumin, R; Haefely, WE; Martin, JR; Pieri, L; Schaffner, R1
Drescher, U; Knoflach, F; Malherbe, P; Mohler, H; Scheurer, L1
Hadingham, KL; Palmer, KJ; Thompson, SA; Wafford, KA; Whiting, PJ1
Atack, JR; McKernan, RM; Smith, AJ1
Atack, JR; Cook, SM; Guiblin, A; McKernan, RM; Moyes, C; Pike, A; Pym, LJ; Rosahl, TW; Scott-Stevens, P; Sohal, B; Watt, AP1

Other Studies

7 other study(ies) available for bretazenil and flunitrazepam

ArticleYear
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
    Journal of medicinal chemistry, 2000, Jan-13, Volume: 43, Issue:1

    Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship

2000
Changes in benzodiazepine-receptor activity modify morphine withdrawal syndrome in mice.
    Drug and alcohol dependence, 1992, Volume: 30, Issue:3

    Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Flumazenil; Flunitrazepam; Male; Mice; Morphine; Receptors, GABA-A; Substance Withdrawal Syndrome

1992
Ro 16-6028: a novel anxiolytic acting as a partial agonist at the benzodiazepine receptor.
    Pharmacopsychiatry, 1988, Volume: 21, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Cats; Conflict, Psychological; Cyclic GMP; Diazepam; Dogs; Flunitrazepam; Mice; Rats; Receptors, GABA-A; Saimiri; Substance Withdrawal Syndrome

1988
Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1

    Topics: Benzodiazepinones; Carbolines; Cells, Cultured; DNA; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Imidazoles; Kinetics; Ligands; Macromolecular Substances; Pyrimidines; Receptors, GABA-A; Recombinant Proteins; Sensitivity and Specificity; Substrate Specificity; Transfection

1993
Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.
    European journal of pharmacology, 1995, Nov-30, Volume: 291, Issue:3

    Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Base Sequence; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; Flunitrazepam; GABA Modulators; Humans; Molecular Sequence Data; Pyrazoles; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Proteins; Sequence Homology, Amino Acid; Triazolam; Xenopus; Zolpidem

1995
Benzodiazepine modulation of recombinant alpha1beta3gamma2 GABA(A) receptor function efficacy determination using the Cytosensor microphysiometer.
    European journal of pharmacology, 1998, Oct-23, Volume: 359, Issue:2-3

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Biosensing Techniques; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Eukaryotic Cells; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pyridines; Receptors, GABA-A; Recombinant Proteins; Time Factors; Zolpidem

1998
Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.
    Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:6

    Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; GABA-A Receptor Agonists; Injections, Intravenous; Ligands; Male; Mice; Mice, Mutant Strains; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Distribution; Triazines

2007